-- dump date 20140619_163642 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_273067.1 15675949 902103 complement(7..498) 1 NC_003112.2 identified by similarity to EGAD:160712; match to protein family HMM PF00583; acetyltransferase 498 902103 NMB0001 Neisseria meningitidis MC58 acetyltransferase NP_273067.1 7 R 122586 CDS NP_273068.1 15675950 902104 complement(502..897) 1 NC_003112.2 hypothetical protein 897 902104 NMB0002 Neisseria meningitidis MC58 hypothetical protein NP_273068.1 502 R 122586 CDS NP_273069.1 15675951 902105 complement(918..2312) 1 NC_003112.2 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2312 gltX 902105 gltX Neisseria meningitidis MC58 glutamyl-tRNA synthetase NP_273069.1 918 R 122586 CDS NP_273070.1 15675952 902106 complement(2517..3161) 1 NC_003112.2 identified by similarity to EGAD:132655; match to protein family HMM PF02698; EpiH/GdmH-like protein 3161 902106 NMB0004 Neisseria meningitidis MC58 EpiH/GdmH-like protein NP_273070.1 2517 R 122586 CDS NP_273071.1 15675953 902107 complement(3158..3511) 1 NC_003112.2 identified by similarity to EGAD:124632; match to protein family HMM PF03960; match to protein family HMM TIGR00014; arsenate reductase 3511 arsC 902107 arsC Neisseria meningitidis MC58 arsenate reductase NP_273071.1 3158 R 122586 CDS NP_273072.1 15675954 902108 3635..4117 1 NC_003112.2 identified by similarity to EGAD:143277; thioredoxin-like protein 4117 902108 NMB0006 Neisseria meningitidis MC58 thioredoxin-like protein NP_273072.1 3635 D 122586 CDS NP_273073.1 15675955 902109 4311..4961 1 NC_003112.2 identified by similarity to EGAD:140012; match to protein family HMM PF00005; match to protein family HMM TIGR00960; ABC transporter ATP-binding protein 4961 ftsE 902109 ftsE Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273073.1 4311 D 122586 CDS NP_273074.1 15675956 902110 4958..5875 1 NC_003112.2 identified by similarity to EGAD:140175; match to protein family HMM PF02687; match to protein family HMM TIGR00439; cell division protein FtsX 5875 902110 NMB0008 Neisseria meningitidis MC58 cell division protein FtsX NP_273074.1 4958 D 122586 CDS NP_273075.1 15675957 902111 5966..6214 1 NC_003112.2 identified by similarity to EGAD:50503; match to protein family HMM PF01722; BolA/YrbA family protein 6214 902111 NMB0009 Neisseria meningitidis MC58 BolA/YrbA family protein NP_273075.1 5966 D 122586 CDS NP_273076.1 15675958 902112 complement(6281..7492) 1 NC_003112.2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 7492 pgk 902112 pgk Neisseria meningitidis MC58 phosphoglycerate kinase NP_273076.1 6281 R 122586 CDS NP_273077.1 15675959 902113 complement(7573..8826) 1 NC_003112.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 8826 murA 902113 murA Neisseria meningitidis MC58 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_273077.1 7573 R 122586 CDS NP_273078.1 15675960 902115 complement(9346..10317) 1 NC_003112.2 identified by similarity to EGAD:30886; match to protein family HMM PF03741; hypothetical protein 10317 902115 NMB0012 Neisseria meningitidis MC58 hypothetical protein NP_273078.1 9346 R 122586 CDS NP_273079.1 15675961 902116 complement(10350..10799) 1 NC_003112.2 identified by similarity to EGAD:90450; match to protein family HMM PF04323; hypothetical protein 10799 902116 NMB0013 Neisseria meningitidis MC58 hypothetical protein NP_273079.1 10350 R 122586 CDS NP_273080.1 15675962 902117 complement(10840..12111) 1 NC_003112.2 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 12111 kdtA 902117 kdtA Neisseria meningitidis MC58 3-deoxy-D-manno-octulosonic-acid transferase NP_273080.1 10840 R 122586 CDS NP_273081.1 15675963 902118 complement(12174..13622) 1 NC_003112.2 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 13622 gnd 902118 gnd Neisseria meningitidis MC58 6-phosphogluconate dehydrogenase NP_273081.1 12174 R 122586 CDS NP_273083.1 15675965 902120 complement(15221..16144) 1 NC_003112.2 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 16144 lpxC 902120 lpxC Neisseria meningitidis MC58 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_273083.1 15221 R 122586 CDS NP_273084.1 15675966 902121 complement(17229..17741) 1 NC_003112.2 identified by similarity to GP:349016; match to protein family HMM PF00114; match to protein family HMM PF07963; match to protein family HMM TIGR02532; pilin PilE 17741 pilE 902121 pilE Neisseria meningitidis MC58 pilin PilE NP_273084.1 17229 R 122586 CDS YP_338284.1 77358699 902122 complement(18517..18927) 1 NC_003112.2 identified by similarity to GP:349528; match to protein family HMM PF00114; pilS cassette 18927 902122 NMB0019 Neisseria meningitidis MC58 pilS cassette YP_338284.1 18517 R 122586 CDS YP_338285.1 77358700 902123 complement(19267..19641) 1 NC_003112.2 identified by similarity to EGAD:138647; match to protein family HMM PF00114; pilS cassette 19641 902123 NMB0020 Neisseria meningitidis MC58 pilS cassette YP_338285.1 19267 R 122586 CDS YP_338286.1 77358701 902124 complement(19918..20292) 1 NC_003112.2 identified by similarity to EGAD:11801; pilS cassette 20292 902124 NMB0021 Neisseria meningitidis MC58 pilS cassette YP_338286.1 19918 R 122586 CDS YP_338287.1 77358702 902125 complement(20832..21170) 1 NC_003112.2 identified by similarity to EGAD:40711; pilS cassette 21170 902125 NMB0022 Neisseria meningitidis MC58 pilS cassette YP_338287.1 20832 R 122586 CDS YP_338288.1 77358703 902126 complement(21470..21877) 1 NC_003112.2 identified by similarity to EGAD:11802; match to protein family HMM PF00114; pilS cassette 21877 902126 NMB0023 Neisseria meningitidis MC58 pilS cassette YP_338288.1 21470 R 122586 CDS YP_338289.1 77358704 902127 complement(21891..22487) 1 NC_003112.2 identified by similarity to EGAD:32664; pilS cassette 22487 902127 NMB0024 Neisseria meningitidis MC58 pilS cassette YP_338289.1 21891 R 122586 CDS YP_338290.1 77358705 902128 complement(22825..23502) 1 NC_003112.2 identified by similarity to EGAD:138648; large pilS cassette 23502 902128 NMB0025 Neisseria meningitidis MC58 large pilS cassette YP_338290.1 22825 R 122586 CDS NP_273092.1 15677981 902129 complement(23528..23875) 1 NC_003112.2 identified by similarity to EGAD:13664; pilS cassette 23875 902129 NMB0026 Neisseria meningitidis MC58 pilS cassette NP_273092.1 23528 R 122586 CDS NP_273093.1 15675967 902130 complement(23904..24233) 1 NC_003112.2 Suggested gene symbol is fbp (PMID:1371354).; identified by similarity to EGAD:15191; match to protein family HMM PF00254; peptidyl-prolyl cis-trans isomerase 24233 902130 NMB0027 Neisseria meningitidis MC58 peptidyl-prolyl cis-trans isomerase NP_273093.1 23904 R 122586 CDS NP_273094.1 15675968 902131 complement(24311..24529) 1 NC_003112.2 hypothetical protein 24529 902131 NMB0028 Neisseria meningitidis MC58 hypothetical protein NP_273094.1 24311 R 122586 CDS NP_273095.1 15675969 902132 24651..25604 1 NC_003112.2 identified by similarity to EGAD:28541; match to protein family HMM PF00389; match to protein family HMM PF02826; glycerate dehydrogenase 25604 hprA 902132 hprA Neisseria meningitidis MC58 glycerate dehydrogenase NP_273095.1 24651 D 122586 CDS NP_273096.1 15675970 902133 complement(25679..27736) 1 NC_003112.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 27736 metG 902133 metG Neisseria meningitidis MC58 methionyl-tRNA synthetase NP_273096.1 25679 R 122586 CDS NP_273097.1 15675971 902134 complement(27852..29690) 1 NC_003112.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 29690 glmS 902134 glmS Neisseria meningitidis MC58 glucosamine--fructose-6-phosphate aminotransferase NP_273097.1 27852 R 122586 CDS NP_273098.1 15675972 902135 29966..30493 1 NC_003112.2 hypothetical protein 30493 902135 NMB0032 Neisseria meningitidis MC58 hypothetical protein NP_273098.1 29966 D 122586 CDS NP_273099.1 15675973 902136 complement(30911..32236) 1 NC_003112.2 identified by similarity to GP:974447; match to protein family HMM PF03562; match to protein family HMM PF06725; membrane-bound lytic murein transglycosylase A 32236 902136 NMB0033 Neisseria meningitidis MC58 membrane-bound lytic murein transglycosylase A NP_273099.1 30911 R 122586 CDS NP_273100.1 15675974 902137 32447..33286 1 NC_003112.2 identified by similarity to EGAD:90733; match to protein family HMM PF03239; hypothetical protein 33286 902137 NMB0034 Neisseria meningitidis MC58 hypothetical protein NP_273100.1 32447 D 122586 CDS NP_273101.1 15675975 902138 33283..34449 1 NC_003112.2 identified by similarity to EGAD:90734; match to protein family HMM PF04302; hypothetical protein 34449 902138 NMB0035 Neisseria meningitidis MC58 hypothetical protein NP_273101.1 33283 D 122586 CDS NP_273102.1 15675976 902139 34713..35978 1 NC_003112.2 identified by similarity to EGAD:11971; match to protein family HMM PF04261; match to protein family HMM TIGR01412; match to protein family HMM TIGR01413; hypothetical protein 35978 902139 NMB0036 Neisseria meningitidis MC58 hypothetical protein NP_273102.1 34713 D 122586 CDS NP_273103.1 15675977 902140 complement(36050..36379) 1 NC_003112.2 identified by similarity to EGAD:35919; match to protein family HMM PF03831; match to protein family HMM TIGR00686; phnA protein 36379 phnA 902140 phnA Neisseria meningitidis MC58 phnA protein NP_273103.1 36050 R 122586 CDS NP_273104.1 15675978 902141 complement(36454..37824) 1 NC_003112.2 identified by similarity to EGAD:40827; match to protein family HMM PF00132; match to protein family HMM PF00483; match to protein family HMM TIGR01173; UDP-N-acetylglucosamine pyrophosphorylase 37824 glmU 902141 glmU Neisseria meningitidis MC58 UDP-N-acetylglucosamine pyrophosphorylase NP_273104.1 36454 R 122586 CDS NP_273107.1 15675981 902144 38916..39917 1 NC_003112.2 identified by similarity to EGAD:159451; match to protein family HMM PF01547; match to protein family HMM TIGR01254; ABC transporter substrate-binding protein 39917 902144 NMB0041 Neisseria meningitidis MC58 ABC transporter substrate-binding protein NP_273107.1 38916 D 122586 CDS NP_273108.1 15675982 902145 40011..40859 1 NC_003112.2 identified by similarity to GP:2708660; match to protein family HMM PF00924; hypothetical protein 40859 902145 NMB0042 Neisseria meningitidis MC58 hypothetical protein NP_273108.1 40011 D 122586 CDS NP_273109.1 15675983 902146 40885..41370 1 NC_003112.2 identified by similarity to EGAD:32599; match to protein family HMM PF02464; match to protein family HMM TIGR00199; hypothetical protein 41370 902146 NMB0043 Neisseria meningitidis MC58 hypothetical protein NP_273109.1 40885 D 122586 CDS NP_273110.1 15675984 902147 complement(41472..43040) 1 NC_003112.2 this is a fusion of 3 domains, an N-termianl thioredoxin domain, and 2 domains at the C-terminus that are methionine sulfoxide reductases, MsrA and MsrB; methionine is modified to form methionine sulfoxide during normal cellular processes and due to oxidat; trifunctional thioredoxin/methionine sulfoxide reductase A/B protein 43040 pilB 902147 pilB Neisseria meningitidis MC58 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein NP_273110.1 41472 R 122586 CDS NP_273111.1 15675985 902148 43186..44451 1 NC_003112.2 identified by similarity to EGAD:6624; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; signal recognition particle protein 44451 pilA 902148 pilA Neisseria meningitidis MC58 signal recognition particle protein NP_273111.1 43186 D 122586 CDS NP_273113.1 15675987 902150 45079..45363 1 NC_003112.2 identified by similarity to GP:2570056; match to protein family HMM PF01541; hypothetical protein 45363 902150 NMB0047 Neisseria meningitidis MC58 hypothetical protein NP_273113.1 45079 D 122586 CDS NP_273115.1 15675988 902152 complement(53030..55180) 1 NC_003112.2 identified by similarity to EGAD:28668; match to protein family HMM PF05976; match to protein family HMM TIGR01666; match to protein family HMM TIGR01667; hypothetical protein 55180 902152 NMB0050 Neisseria meningitidis MC58 hypothetical protein NP_273115.1 53030 R 122586 CDS NP_273116.1 15675989 902153 complement(55466..56692) 1 NC_003112.2 identified by similarity to EGAD:32627; match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility protein 56692 902153 NMB0051 Neisseria meningitidis MC58 twitching motility protein NP_273116.1 55466 R 122586 CDS NP_273117.1 15675990 902154 complement(56855..57898) 1 NC_003112.2 identified by similarity to GP:3328331; match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility protein PilT 57898 pilT-1 902154 pilT-1 Neisseria meningitidis MC58 twitching motility protein PilT NP_273117.1 56855 R 122586 CDS NP_273118.1 15675991 902155 58018..58704 1 NC_003112.2 identified by similarity to EGAD:10097; match to protein family HMM PF01168; match to protein family HMM TIGR00044; hypothetical protein 58704 902155 NMB0053 Neisseria meningitidis MC58 hypothetical protein NP_273118.1 58018 D 122586 CDS NP_273119.1 15675992 902156 58704..59111 1 NC_003112.2 hypothetical protein 59111 902156 NMB0054 Neisseria meningitidis MC58 hypothetical protein NP_273119.1 58704 D 122586 CDS NP_273120.1 15675993 902157 59160..59951 1 NC_003112.2 identified by similarity to EGAD:34246; match to protein family HMM PF01089; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 59951 proC 902157 proC Neisseria meningitidis MC58 pyrroline-5-carboxylate reductase NP_273120.1 59160 D 122586 CDS NP_273121.1 15675994 902158 60098..60514 1 NC_003112.2 identified by similarity to GP:3064140; match to protein family HMM PF01258; match to protein family HMM TIGR02420; DnaK suppressor protein 60514 dksA 902158 dksA Neisseria meningitidis MC58 DnaK suppressor protein NP_273121.1 60098 D 122586 CDS NP_273124.1 15675997 902166 66979..68100 1 NC_003112.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 68100 dnaJ 902166 dnaJ Neisseria meningitidis MC58 molecular chaperone DnaJ NP_273124.1 66979 D 122586 CDS NP_273125.1 15675998 902167 68296..70314 1 NC_003112.2 identified by similarity to EGAD:133403; match to protein family HMM PF03169; match to protein family HMM TIGR00728; match to protein family HMM TIGR00733; hypothetical protein 70314 902167 NMB0060 Neisseria meningitidis MC58 hypothetical protein NP_273125.1 68296 D 122586 CDS YP_008920703.1 566328916 902168 complement(70358..70930) 1 NC_003112.2 dTDP-4-dehydrorhamnose 3,5-epimerase 70930 rfbC 902168 rfbC Neisseria meningitidis MC58 dTDP-4-dehydrorhamnose 3,5-epimerase YP_008920703.1 70358 R 122586 CDS NP_273126.1 15675999 902169 complement(70969..71835) 1 NC_003112.2 identified by similarity to EGAD:23719; match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 71835 rfbA-1 902169 rfbA-1 Neisseria meningitidis MC58 glucose-1-phosphate thymidylyltransferase NP_273126.1 70969 R 122586 CDS NP_273127.1 15676000 902170 complement(71898..72965) 1 NC_003112.2 identified by similarity to EGAD:40672; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-D-glucose 4,6-dehydratase 72965 rfbB-1 902170 rfbB-1 Neisseria meningitidis MC58 dTDP-D-glucose 4,6-dehydratase NP_273127.1 71898 R 122586 CDS NP_273128.1 15676001 902171 complement(73081..74100) 1 NC_003112.2 identified by similarity to EGAD:16384; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 74100 galE 902171 galE Neisseria meningitidis MC58 UDP-glucose 4-epimerase NP_273128.1 73081 R 122586 CDS NP_273129.1 15676002 902172 74483..75409 1 NC_003112.2 hypothetical protein 75409 902172 NMB0065 Neisseria meningitidis MC58 hypothetical protein NP_273129.1 74483 D 122586 CDS NP_273130.1 15676003 902173 75694..76428 1 NC_003112.2 identified by similarity to EGAD:8424; match to protein family HMM PF00398; rRNA adenine N-6-methyltransferase 76428 ermC 902173 ermC Neisseria meningitidis MC58 rRNA adenine N-6-methyltransferase NP_273130.1 75694 D 122586 CDS NP_273131.1 15677983 903210 complement(76613..77290) 1 NC_003112.2 identified by similarity to GP:530041; polysialic acid capsule biosynthesis protein SiaD 77290 903210 NMB0067 Neisseria meningitidis MC58 polysialic acid capsule biosynthesis protein SiaD NP_273131.1 76613 R 122586 CDS NP_273132.1 15676004 902174 complement(77374..78423) 1 NC_003112.2 identified by similarity to EGAD:19609; match to protein family HMM PF01354; match to protein family HMM PF03102; polysialic acid capsule biosynthesis protein SiaC 78423 siaC 902174 siaC Neisseria meningitidis MC58 polysialic acid capsule biosynthesis protein SiaC NP_273132.1 77374 R 122586 CDS NP_273133.1 15676005 902175 complement(78424..79110) 1 NC_003112.2 identified by similarity to EGAD:14454; match to protein family HMM PF02348; polysialic acid capsule biosynthesis protein SiaB 79110 siaB 902175 siaB Neisseria meningitidis MC58 polysialic acid capsule biosynthesis protein SiaB NP_273133.1 78424 R 122586 CDS NP_273134.1 15676006 902176 complement(79114..80247) 1 NC_003112.2 identified by similarity to GP:460145; match to protein family HMM PF02350; polysialic acid capsule biosynthesis protein SynX 80247 synX 902176 synX Neisseria meningitidis MC58 polysialic acid capsule biosynthesis protein SynX NP_273134.1 79114 R 122586 CDS NP_273135.1 15676007 902177 80382..81557 1 NC_003112.2 identified by similarity to EGAD:23947; match to protein family HMM PF02563; capsule polysaccharide export outer membrane protein 81557 ctrA 902177 ctrA Neisseria meningitidis MC58 capsule polysaccharide export outer membrane protein NP_273135.1 80382 D 122586 CDS NP_273136.1 15676008 902178 81572..82735 1 NC_003112.2 identified by similarity to EGAD:20633; match to protein family HMM PF02706; match to protein family HMM TIGR01010; capsule polysaccharide export inner-membrane protein 82735 ctrB 902178 ctrB Neisseria meningitidis MC58 capsule polysaccharide export inner-membrane protein NP_273136.1 81572 D 122586 CDS NP_273137.1 15676009 902179 82735..83532 1 NC_003112.2 identified by similarity to EGAD:15907; match to protein family HMM PF01061; capsule polysaccharide export inner-membrane protein 83532 ctrC 902179 ctrC Neisseria meningitidis MC58 capsule polysaccharide export inner-membrane protein NP_273137.1 82735 D 122586 CDS NP_273138.1 15676010 902180 83529..84179 1 NC_003112.2 identified by similarity to EGAD:15804; match to protein family HMM PF00005; capsule polysaccharide export ATP-binding protein CtrD 84179 ctrD 902180 ctrD Neisseria meningitidis MC58 capsule polysaccharide export ATP-binding protein CtrD NP_273138.1 83529 D 122586 CDS NP_273139.1 15676011 902181 84243..86516 1 NC_003112.2 identified by similarity to EGAD:97859; match to protein family HMM PF00575; transcriptional accessory protein Tex 86516 902181 NMB0075 Neisseria meningitidis MC58 transcriptional accessory protein Tex NP_273139.1 84243 D 122586 CDS NP_273140.1 15677984 903209 87536..87886 1 NC_003112.2 identified by similarity to EGAD:150447; site-specific DNA methylase, truncation 87886 903209 NMB0077 Neisseria meningitidis MC58 site-specific DNA methylase, truncation NP_273140.1 87536 D 122586 CDS NP_273141.1 15677985 903208 87929..88585 1 NC_003112.2 identified by similarity to EGAD:19406; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase, truncation 88585 903208 NMB0078 Neisseria meningitidis MC58 UDP-glucose 4-epimerase, truncation NP_273141.1 87929 D 122586 CDS NP_273142.1 15676012 902183 88701..89768 1 NC_003112.2 identified by similarity to EGAD:40672; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-D-glucose 4,6-dehydratase 89768 rfbB-2 902183 rfbB-2 Neisseria meningitidis MC58 dTDP-D-glucose 4,6-dehydratase NP_273142.1 88701 D 122586 CDS NP_273143.1 15676013 902184 89831..90697 1 NC_003112.2 identified by similarity to EGAD:23719; match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 90697 rfbA-2 902184 rfbA-2 Neisseria meningitidis MC58 glucose-1-phosphate thymidylyltransferase NP_273143.1 89831 D 122586 CDS NP_273144.1 15676014 902185 90736..91290 1 NC_003112.2 identified by similarity to GP:3132257; match to protein family HMM PF00908; match to protein family HMM TIGR01221; dTDP-4-keto-6-deoxy-D-glucose-3,6-epimerase 91290 902185 NMB0081 Neisseria meningitidis MC58 dTDP-4-keto-6-deoxy-D-glucose-3,6-epimerase NP_273144.1 90736 D 122586 CDS NP_273145.1 15676015 902186 91315..93429 1 NC_003112.2 identified by similarity to EGAD:15481; match to protein family HMM PF05159; capsule polysaccharide modification protein 93429 lipA 902186 lipA Neisseria meningitidis MC58 capsule polysaccharide modification protein NP_273145.1 91315 D 122586 CDS NP_273146.1 15676016 902187 93566..94825 1 NC_003112.2 identified by similarity to EGAD:7740; match to protein family HMM PF05159; capsule polysaccharide modification protein 94825 lipB 902187 lipB Neisseria meningitidis MC58 capsule polysaccharide modification protein NP_273146.1 93566 D 122586 CDS NP_273147.1 15676017 902189 96815..98029 1 NC_003112.2 identified by similarity to EGAD:28525; match to protein family HMM PF03616; match to protein family HMM TIGR00210; sodium/glutamate symport carrier protein 98029 gltS 902189 gltS Neisseria meningitidis MC58 sodium/glutamate symport carrier protein NP_273147.1 96815 D 122586 CDS NP_273148.1 15676018 902190 98128..99144 1 NC_003112.2 hypothetical protein 99144 902190 NMB0086 Neisseria meningitidis MC58 hypothetical protein NP_273148.1 98128 D 122586 CDS NP_273149.1 15676019 902191 99155..99352 1 NC_003112.2 hypothetical protein 99352 902191 NMB0087 Neisseria meningitidis MC58 hypothetical protein NP_273149.1 99155 D 122586 CDS NP_273150.1 15676020 902192 complement(99777..101177) 1 NC_003112.2 identified by similarity to EGAD:16317; match to protein family HMM PF03349; outer membrane protein P1 101177 902192 NMB0088 Neisseria meningitidis MC58 outer membrane protein P1 NP_273150.1 99777 R 122586 CDS NP_273151.1 15676021 902193 complement(101492..102964) 1 NC_003112.2 identified by similarity to EGAD:21471; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; pyruvate kinase 102964 pykA 902193 pykA Neisseria meningitidis MC58 pyruvate kinase NP_273151.1 101492 R 122586 CDS NP_273152.1 15676022 902195 104406..104642 1 NC_003112.2 hypothetical protein 104642 902195 NMB0091 Neisseria meningitidis MC58 hypothetical protein NP_273152.1 104406 D 122586 CDS NP_273153.1 15676023 902196 104636..104863 1 NC_003112.2 hypothetical protein 104863 902196 NMB0092 Neisseria meningitidis MC58 hypothetical protein NP_273153.1 104636 D 122586 CDS NP_273154.1 15676024 902197 104863..104949 1 NC_003112.2 hypothetical protein 104949 902197 NMB0093 Neisseria meningitidis MC58 hypothetical protein NP_273154.1 104863 D 122586 CDS NP_273159.1 15676029 902204 complement(109631..109777) 1 NC_003112.2 hypothetical protein 109777 902204 NMB0100 Neisseria meningitidis MC58 hypothetical protein NP_273159.1 109631 R 122586 CDS NP_273160.1 15676030 902206 110615..111133 1 NC_003112.2 hypothetical protein 111133 902206 NMB0102 Neisseria meningitidis MC58 hypothetical protein NP_273160.1 110615 D 122586 CDS NP_273161.1 15676031 902207 complement(111409..111903) 1 NC_003112.2 identified by similarity to GP:2909665; match to protein family HMM PF03412; bacteriocin resistance protein 111903 902207 NMB0103 Neisseria meningitidis MC58 bacteriocin resistance protein NP_273161.1 111409 R 122586 CDS NP_273162.1 15676032 902208 complement(112406..113080) 1 NC_003112.2 hypothetical protein 113080 902208 NMB0104 Neisseria meningitidis MC58 hypothetical protein NP_273162.1 112406 R 122586 CDS NP_273163.1 15676033 902209 complement(113362..114204) 1 NC_003112.2 identified by similarity to EGAD:108538; match to protein family HMM PF00583; PhnO-like protein 114204 902209 NMB0105 Neisseria meningitidis MC58 PhnO-like protein NP_273163.1 113362 R 122586 CDS NP_273164.1 15676034 902210 114443..115363 1 NC_003112.2 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 115363 pyrB 902210 pyrB Neisseria meningitidis MC58 aspartate carbamoyltransferase NP_273164.1 114443 D 122586 CDS NP_273165.1 15676035 902211 115373..115831 1 NC_003112.2 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 115831 pyrI 902211 pyrI Neisseria meningitidis MC58 aspartate carbamoyltransferase NP_273165.1 115373 D 122586 CDS NP_273166.1 15676036 902212 115896..116561 1 NC_003112.2 hypothetical protein 116561 902212 NMB0108 Neisseria meningitidis MC58 hypothetical protein NP_273166.1 115896 D 122586 CDS NP_273167.1 15676037 902213 complement(116624..117955) 1 NC_003112.2 identified by similarity to EGAD:109565; match to protein family HMM PF01476; hypothetical protein 117955 902213 NMB0109 Neisseria meningitidis MC58 hypothetical protein NP_273167.1 116624 R 122586 CDS NP_273168.1 15676038 902214 118025..118528 1 NC_003112.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 118528 def 902214 def Neisseria meningitidis MC58 peptide deformylase NP_273168.1 118025 D 122586 CDS NP_273169.1 15676039 902215 118615..119541 1 NC_003112.2 identified by similarity to EGAD:24704; match to protein family HMM PF00551; match to protein family HMM PF02911; match to protein family HMM TIGR00460; methionyl-tRNA formyltransferase 119541 fmt 902215 fmt Neisseria meningitidis MC58 methionyl-tRNA formyltransferase NP_273169.1 118615 D 122586 CDS NP_273170.1 15676040 902216 119620..120879 1 NC_003112.2 identified by similarity to EGAD:36279; match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; 16S RNA methyltransferase 120879 rsmB 902216 rsmB Neisseria meningitidis MC58 16S RNA methyltransferase NP_273170.1 119620 D 122586 CDS NP_273171.1 15676041 902217 120899..121441 1 NC_003112.2 hypothetical protein 121441 902217 NMB0113 Neisseria meningitidis MC58 hypothetical protein NP_273171.1 120899 D 122586 CDS NP_273172.1 15676042 902218 121441..123561 1 NC_003112.2 identified by similarity to EGAD:163355; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; nitrogen regulation protein NtrY 123561 902218 NMB0114 Neisseria meningitidis MC58 nitrogen regulation protein NtrY NP_273172.1 121441 D 122586 CDS NP_273173.1 15676043 902219 123554..124831 1 NC_003112.2 identified by similarity to EGAD:5624; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199; nitrogen assimilation regulatory protein NtrX 124831 ntrX 902219 ntrX Neisseria meningitidis MC58 nitrogen assimilation regulatory protein NtrX NP_273173.1 123554 D 122586 CDS NP_273174.1 15676044 902220 124922..126115 1 NC_003112.2 identified by similarity to EGAD:27998; match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA processing protein DprA 126115 dprA 902220 dprA Neisseria meningitidis MC58 DNA processing protein DprA NP_273174.1 124922 D 122586 CDS NP_273175.1 15676045 902221 126141..126602 1 NC_003112.2 identified by similarity to EGAD:6532; match to protein family HMM PF04361; smg protein 126602 902221 NMB0117 Neisseria meningitidis MC58 smg protein NP_273175.1 126141 D 122586 CDS NP_273176.1 15676046 902222 126674..128980 1 NC_003112.2 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 128980 topA 902222 topA Neisseria meningitidis MC58 DNA topoisomerase I NP_273176.1 126674 D 122586 CDS NP_273177.1 15676047 902223 complement(129053..129748) 1 NC_003112.2 hypothetical protein 129748 902223 NMB0119 Neisseria meningitidis MC58 hypothetical protein NP_273177.1 129053 R 122586 CDS NP_273178.1 15676048 902224 complement(129768..130319) 1 NC_003112.2 hypothetical protein 130319 902224 NMB0120 Neisseria meningitidis MC58 hypothetical protein NP_273178.1 129768 R 122586 CDS NP_273179.1 15676049 902225 130438..130815 1 NC_003112.2 identified by similarity to EGAD:28447; match to protein family HMM PF01381; hypothetical protein 130815 902225 NMB0121 Neisseria meningitidis MC58 hypothetical protein NP_273179.1 130438 D 122586 CDS NP_273180.1 15676050 902226 130904..131473 1 NC_003112.2 identified by similarity to EGAD:7463; match to protein family HMM PF03602; match to protein family HMM TIGR00095; hypothetical protein 131473 902226 NMB0122 Neisseria meningitidis MC58 hypothetical protein NP_273180.1 130904 D 122586 CDS NP_273181.1 15676051 902227 131596..131847 1 NC_003112.2 identified by similarity to EGAD:13273; match to protein family HMM PF00037; ferredoxin, 4Fe-4S type 131847 902227 NMB0123 Neisseria meningitidis MC58 ferredoxin, 4Fe-4S type NP_273181.1 131596 D 122586 CDS NP_273182.1 15676052 902231 132264..133448 1 NC_003112.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 133448 tufB 902231 tufB Neisseria meningitidis MC58 elongation factor Tu NP_273182.1 132264 D 122586 CDS NP_273183.1 15676053 902233 133645..133923 1 NC_003112.2 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 133923 secE 902233 secE Neisseria meningitidis MC58 preprotein translocase subunit SecE NP_273183.1 133645 D 122586 CDS NP_273184.1 15676054 902234 133925..134461 1 NC_003112.2 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 134461 nusG 902234 nusG Neisseria meningitidis MC58 transcription antitermination protein NusG NP_273184.1 133925 D 122586 CDS NP_273185.1 15676055 902235 134562..134996 1 NC_003112.2 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 134996 rplK 902235 rplK Neisseria meningitidis MC58 50S ribosomal protein L11 NP_273185.1 134562 D 122586 CDS NP_273186.1 15676056 902236 134996..135691 1 NC_003112.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 135691 rplA 902236 rplA Neisseria meningitidis MC58 50S ribosomal protein L1 NP_273186.1 134996 D 122586 CDS NP_273187.1 15676057 902237 135760..135903 1 NC_003112.2 hypothetical protein 135903 902237 NMB0129 Neisseria meningitidis MC58 hypothetical protein NP_273187.1 135760 D 122586 CDS NP_273188.1 15676058 902238 135921..136421 1 NC_003112.2 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 136421 rplJ 902238 rplJ Neisseria meningitidis MC58 50S ribosomal protein L10 NP_273188.1 135921 D 122586 CDS NP_273189.1 15676059 902239 136479..136850 1 NC_003112.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 136850 rplL 902239 rplL Neisseria meningitidis MC58 50S ribosomal protein L7/L12 NP_273189.1 136479 D 122586 CDS NP_273190.1 15676060 902240 137034..141218 1 NC_003112.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 141218 rpoB 902240 rpoB Neisseria meningitidis MC58 DNA-directed RNA polymerase subunit beta NP_273190.1 137034 D 122586 CDS NP_273191.1 15676061 902241 141375..145550 1 NC_003112.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 145550 rpoC 902241 rpoC Neisseria meningitidis MC58 DNA-directed RNA polymerase subunit beta' NP_273191.1 141375 D 122586 CDS NP_273192.1 15676062 902242 145842..146099 1 NC_003112.2 hypothetical protein 146099 902242 NMB0134 Neisseria meningitidis MC58 hypothetical protein NP_273192.1 145842 D 122586 CDS NP_273193.1 15676063 902243 146096..146245 1 NC_003112.2 identified by similarity to GP:3414689; match to protein family HMM PF04575; hypothetical protein 146245 902243 NMB0135 Neisseria meningitidis MC58 hypothetical protein NP_273193.1 146096 D 122586 CDS NP_273194.1 15676064 902244 146424..146795 1 NC_003112.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 146795 rpsL 902244 rpsL Neisseria meningitidis MC58 30S ribosomal protein S12 NP_273194.1 146424 D 122586 CDS NP_273195.1 15676065 902245 146913..147383 1 NC_003112.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 147383 rpsG 902245 rpsG Neisseria meningitidis MC58 30S ribosomal protein S7 NP_273195.1 146913 D 122586 CDS NP_273196.1 15676066 902246 147402..149507 1 NC_003112.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 149507 fusA 902246 fusA Neisseria meningitidis MC58 elongation factor G NP_273196.1 147402 D 122586 CDS NP_273197.1 15676067 902247 149593..150777 1 NC_003112.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 150777 tufA 902247 tufA Neisseria meningitidis MC58 elongation factor Tu NP_273197.1 149593 D 122586 CDS NP_273198.1 15676068 902248 150795..151106 1 NC_003112.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 151106 rpsJ 902248 rpsJ Neisseria meningitidis MC58 30S ribosomal protein S10 NP_273198.1 150795 D 122586 CDS NP_273199.1 15677986 903207 151248..151613 1 NC_003112.2 identified by similarity to GP:3901097; transposase, truncation 151613 903207 NMB0141 Neisseria meningitidis MC58 transposase, truncation NP_273199.1 151248 D 122586 CDS NP_273200.1 15676069 902249 151784..152428 1 NC_003112.2 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 152428 rplC 902249 rplC Neisseria meningitidis MC58 50S ribosomal protein L3 NP_273200.1 151784 D 122586 CDS NP_273201.1 15676070 902250 152428..153048 1 NC_003112.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 153048 rplD 902250 rplD Neisseria meningitidis MC58 50S ribosomal protein L4 NP_273201.1 152428 D 122586 CDS NP_273202.1 15676071 902251 153045..153359 1 NC_003112.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 153359 rplW 902251 rplW Neisseria meningitidis MC58 50S ribosomal protein L23 NP_273202.1 153045 D 122586 CDS NP_273203.1 15676072 902252 153365..154198 1 NC_003112.2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 154198 rplB 902252 rplB Neisseria meningitidis MC58 50S ribosomal protein L2 NP_273203.1 153365 D 122586 CDS NP_273204.1 15676073 902253 154205..154483 1 NC_003112.2 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 154483 rpsS 902253 rpsS Neisseria meningitidis MC58 30S ribosomal protein S19 NP_273204.1 154205 D 122586 CDS NP_273205.1 15676074 902254 154492..154821 1 NC_003112.2 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 154821 rplV 902254 rplV Neisseria meningitidis MC58 50S ribosomal protein L22 NP_273205.1 154492 D 122586 CDS NP_273206.1 15676075 902255 154831..155523 1 NC_003112.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 155523 rpsC 902255 rpsC Neisseria meningitidis MC58 30S ribosomal protein S3 NP_273206.1 154831 D 122586 CDS NP_273207.1 15676076 902256 155507..155923 1 NC_003112.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 155923 rplP 902256 rplP Neisseria meningitidis MC58 50S ribosomal protein L16 NP_273207.1 155507 D 122586 CDS NP_273208.1 15676077 902257 155923..156114 1 NC_003112.2 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 156114 rpmC 902257 rpmC Neisseria meningitidis MC58 50S ribosomal protein L29 NP_273208.1 155923 D 122586 CDS NP_273209.1 15676078 902258 156114..156377 1 NC_003112.2 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 156377 rpsQ 902258 rpsQ Neisseria meningitidis MC58 30S ribosomal protein S17 NP_273209.1 156114 D 122586 CDS NP_273210.1 15676079 902259 156599..156967 1 NC_003112.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 156967 rplN 902259 rplN Neisseria meningitidis MC58 50S ribosomal protein L14 NP_273210.1 156599 D 122586 CDS NP_273211.1 15676080 902260 156979..157302 1 NC_003112.2 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 157302 rplX 902260 rplX Neisseria meningitidis MC58 50S ribosomal protein L24 NP_273211.1 156979 D 122586 CDS NP_273212.1 15676081 902261 157312..157851 1 NC_003112.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 157851 rplE 902261 rplE Neisseria meningitidis MC58 50S ribosomal protein L5 NP_273212.1 157312 D 122586 CDS NP_273213.1 15676082 902262 157854..158159 1 NC_003112.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 158159 rpsN 902262 rpsN Neisseria meningitidis MC58 30S ribosomal protein S14 NP_273213.1 157854 D 122586 CDS NP_273214.1 15676083 902263 158175..158567 1 NC_003112.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 158567 rpsH 902263 rpsH Neisseria meningitidis MC58 30S ribosomal protein S8 NP_273214.1 158175 D 122586 CDS NP_273215.1 15676084 902264 158581..159114 1 NC_003112.2 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 159114 rplF 902264 rplF Neisseria meningitidis MC58 50S ribosomal protein L6 NP_273215.1 158581 D 122586 CDS NP_273216.1 15676085 902265 159128..159481 1 NC_003112.2 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 159481 rplR 902265 rplR Neisseria meningitidis MC58 50S ribosomal protein L18 NP_273216.1 159128 D 122586 CDS NP_273217.1 15676086 902266 159500..160018 1 NC_003112.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 160018 rpsE 902266 rpsE Neisseria meningitidis MC58 30S ribosomal protein S5 NP_273217.1 159500 D 122586 CDS NP_273218.1 15676087 902267 160011..160196 1 NC_003112.2 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 160196 rpmD 902267 rpmD Neisseria meningitidis MC58 50S ribosomal protein L30 NP_273218.1 160011 D 122586 CDS NP_273219.1 15676088 902268 160198..160632 1 NC_003112.2 late assembly protein; 50S ribosomal protein L15 160632 rplO 902268 rplO Neisseria meningitidis MC58 50S ribosomal protein L15 NP_273219.1 160198 D 122586 CDS NP_273220.1 15676089 902269 160644..161954 1 NC_003112.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 161954 secY 902269 secY Neisseria meningitidis MC58 preprotein translocase subunit SecY NP_273220.1 160644 D 122586 CDS NP_273221.1 15676090 902270 161959..162177 1 NC_003112.2 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 162177 infA 902270 infA Neisseria meningitidis MC58 translation initiation factor IF-1 NP_273221.1 161959 D 122586 CDS NP_273222.1 15676091 902271 162198..162311 1 NC_003112.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 162311 rpmJ 902271 rpmJ Neisseria meningitidis MC58 50S ribosomal protein L36 NP_273222.1 162198 D 122586 CDS NP_273223.1 15676092 902272 162377..162739 1 NC_003112.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 162739 rpsM 902272 rpsM Neisseria meningitidis MC58 30S ribosomal protein S13 NP_273223.1 162377 D 122586 CDS NP_273224.1 15676093 902273 162759..163154 1 NC_003112.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 163154 rpsK 902273 rpsK Neisseria meningitidis MC58 30S ribosomal protein S11 NP_273224.1 162759 D 122586 CDS NP_273225.1 15676094 902274 163174..163794 1 NC_003112.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 163794 rpsD 902274 rpsD Neisseria meningitidis MC58 30S ribosomal protein S4 NP_273225.1 163174 D 122586 CDS NP_273226.1 15676095 902275 163820..164806 1 NC_003112.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 164806 rpoA 902275 rpoA Neisseria meningitidis MC58 DNA-directed RNA polymerase subunit alpha NP_273226.1 163820 D 122586 CDS NP_273227.1 15676096 902276 164830..165198 1 NC_003112.2 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 165198 rplQ 902276 rplQ Neisseria meningitidis MC58 50S ribosomal protein L17 NP_273227.1 164830 D 122586 CDS NP_273228.1 15676097 902277 165345..166058 1 NC_003112.2 blocks the formation of polar Z-ring septums; septum formation inhibitor 166058 minC 902277 minC Neisseria meningitidis MC58 septum formation inhibitor NP_273228.1 165345 D 122586 CDS NP_273229.1 15676098 902278 166086..166901 1 NC_003112.2 identified by similarity to EGAD:13527; match to protein family HMM PF01656; match to protein family HMM TIGR01968; septum site-determining protein 166901 minD 902278 minD Neisseria meningitidis MC58 septum site-determining protein NP_273229.1 166086 D 122586 CDS NP_273230.1 15676099 902279 166905..167168 1 NC_003112.2 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 167168 minE 902279 minE Neisseria meningitidis MC58 cell division topological specificity factor MinE NP_273230.1 166905 D 122586 CDS NP_273231.1 15676100 902280 167172..168092 1 NC_003112.2 identified by similarity to EGAD:137604; match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 168092 902280 NMB0173 Neisseria meningitidis MC58 LysR family transcriptional regulator NP_273231.1 167172 D 122586 CDS NP_273232.1 15676101 902281 complement(168422..171259) 1 NC_003112.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 171259 valS 902281 valS Neisseria meningitidis MC58 valyl-tRNA synthetase NP_273232.1 168422 R 122586 CDS NP_273233.1 15676102 902282 complement(171356..172165) 1 NC_003112.2 identified by similarity to EGAD:21714; match to protein family HMM PF02535; zinc transporter ZupT 172165 902282 NMB0175 Neisseria meningitidis MC58 zinc transporter ZupT NP_273233.1 171356 R 122586 CDS NP_273234.1 15676103 902283 complement(172346..173602) 1 NC_003112.2 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 173602 dadA 902283 dadA Neisseria meningitidis MC58 D-amino acid dehydrogenase small subunit NP_273234.1 172346 R 122586 CDS NP_273235.1 15676104 902284 complement(173681..175072) 1 NC_003112.2 identified by similarity to EGAD:90049; match to protein family HMM PF01235; match to protein family HMM TIGR00835; sodium/alanine symporter 175072 902284 NMB0177 Neisseria meningitidis MC58 sodium/alanine symporter NP_273235.1 173681 R 122586 CDS NP_273236.1 15676105 902285 complement(175429..176205) 1 NC_003112.2 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 176205 lpxA 902285 lpxA Neisseria meningitidis MC58 UDP-N-acetylglucosamine acyltransferase NP_273236.1 175429 R 122586 CDS NP_273237.1 15676106 902286 complement(176292..176741) 1 NC_003112.2 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 176741 fabZ 902286 fabZ Neisseria meningitidis MC58 (3R)-hydroxymyristoyl-ACP dehydratase NP_273237.1 176292 R 122586 CDS NP_273238.1 15676107 902287 complement(176775..177821) 1 NC_003112.2 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 177821 lpxD 902287 lpxD Neisseria meningitidis MC58 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_273238.1 176775 R 122586 CDS NP_273239.1 15676108 902288 complement(177854..178354) 1 NC_003112.2 identified by similarity to EGAD:24192; match to protein family HMM PF03938; outer membrane protein OmpH 178354 902288 NMB0181 Neisseria meningitidis MC58 outer membrane protein OmpH NP_273239.1 177854 R 122586 CDS NP_273240.1 15676109 902289 complement(178420..180813) 1 NC_003112.2 identified by similarity to GP:2460281; match to protein family HMM PF01103; match to protein family HMM PF07244; outer membrane protein OMP85 180813 omp85 902289 omp85 Neisseria meningitidis MC58 outer membrane protein OMP85 NP_273240.1 178420 R 122586 CDS NP_273241.1 15676110 902290 complement(180870..182210) 1 NC_003112.2 identified by similarity to EGAD:8229; match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054; hypothetical protein 182210 902290 NMB0183 Neisseria meningitidis MC58 hypothetical protein NP_273241.1 180870 R 122586 CDS NP_273242.1 15676111 902291 complement(182245..183429) 1 NC_003112.2 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 183429 dxr 902291 dxr Neisseria meningitidis MC58 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_273242.1 182245 R 122586 CDS NP_273243.1 15676112 902292 complement(183485..184282) 1 NC_003112.2 identified by similarity to EGAD:46780; match to protein family HMM PF01148; phosphatidate cytidylyltransferase 184282 cdsA 902292 cdsA Neisseria meningitidis MC58 phosphatidate cytidylyltransferase NP_273243.1 183485 R 122586 CDS NP_273244.1 15676113 902293 complement(184285..185031) 1 NC_003112.2 identified by similarity to EGAD:35926; match to protein family HMM PF01255; match to protein family HMM TIGR00055; undecaprenyl pyrophosphate synthetase 185031 uppS 902293 uppS Neisseria meningitidis MC58 undecaprenyl pyrophosphate synthetase NP_273244.1 184285 R 122586 CDS NP_273245.1 15676114 902294 complement(185087..185644) 1 NC_003112.2 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 185644 frr 902294 frr Neisseria meningitidis MC58 ribosome recycling factor NP_273245.1 185087 R 122586 CDS NP_273246.1 15676115 902295 complement(185824..186951) 1 NC_003112.2 identified by similarity to EGAD:9221; hypothetical protein 186951 902295 NMB0188 Neisseria meningitidis MC58 hypothetical protein NP_273246.1 185824 R 122586 CDS NP_273248.1 15676117 902298 187942..188565 1 NC_003112.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 188565 gidB 902298 gidB Neisseria meningitidis MC58 16S rRNA methyltransferase GidB NP_273248.1 187942 D 122586 CDS NP_273249.1 15676118 902299 188664..189437 1 NC_003112.2 identified by similarity to EGAD:5746; match to protein family HMM PF01656; ParA family protein 189437 902299 NMB0191 Neisseria meningitidis MC58 ParA family protein NP_273249.1 188664 D 122586 CDS NP_273250.1 15676119 902300 complement(190697..191281) 1 NC_003112.2 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 191281 rnhB 902300 rnhB Neisseria meningitidis MC58 ribonuclease HII NP_273250.1 190697 R 122586 CDS NP_273251.1 15676120 902301 complement(191350..193245) 1 NC_003112.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 193245 gidA 902301 gidA Neisseria meningitidis MC58 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_273251.1 191350 R 122586 CDS NP_273252.1 15676121 902302 complement(193571..194998) 1 NC_003112.2 identified by similarity to EGAD:28821; match to protein family HMM PF01235; match to protein family HMM TIGR00835; amino acid symporter 194998 902302 NMB0194 Neisseria meningitidis MC58 amino acid symporter NP_273252.1 193571 R 122586 CDS NP_273253.1 15676122 902303 195140..196147 1 NC_003112.2 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 196147 pdxA 902303 pdxA Neisseria meningitidis MC58 4-hydroxythreonine-4-phosphate dehydrogenase NP_273253.1 195140 D 122586 CDS NP_273254.1 15676123 902304 complement(197445..200204) 1 NC_003112.2 identified by similarity to GP:49116; match to protein family HMM PF00575; match to protein family HMM TIGR00757; ribonuclease E 200204 rne 902304 rne Neisseria meningitidis MC58 ribonuclease E NP_273254.1 197445 R 122586 CDS NP_273256.1 15676125 902306 200697..201689 1 NC_003112.2 identified by similarity to EGAD:7861; match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase C 201689 rluC 902306 rluC Neisseria meningitidis MC58 ribosomal large subunit pseudouridine synthase C NP_273256.1 200697 D 122586 CDS NP_273257.1 15676126 902307 201737..202909 1 NC_003112.2 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 202909 lpxB 902307 lpxB Neisseria meningitidis MC58 lipid-A-disaccharide synthase NP_273257.1 201737 D 122586 CDS NP_273258.1 15676127 902308 complement(203119..203508) 1 NC_003112.2 hypothetical protein 203508 902308 NMB0200 Neisseria meningitidis MC58 hypothetical protein NP_273258.1 203119 R 122586 CDS NP_273259.1 15676128 902309 203731..204141 1 NC_003112.2 hypothetical protein 204141 902309 NMB0201 Neisseria meningitidis MC58 hypothetical protein NP_273259.1 203731 D 122586 CDS NP_273261.1 15676130 902311 complement(204405..205214) 1 NC_003112.2 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 205214 dapB 902311 dapB Neisseria meningitidis MC58 dihydrodipicolinate reductase NP_273261.1 204405 R 122586 CDS NP_273262.1 15676131 902312 complement(205224..205601) 1 NC_003112.2 identified by similarity to SP:P23089; match to protein family HMM PF04355; lipoprotein 205601 902312 NMB0204 Neisseria meningitidis MC58 lipoprotein NP_273262.1 205224 R 122586 CDS NP_273263.1 15676132 902313 205820..206254 1 NC_003112.2 identified by similarity to EGAD:14408; match to protein family HMM PF01475; ferric uptake regulation protein 206254 fur 902313 fur Neisseria meningitidis MC58 ferric uptake regulation protein NP_273263.1 205820 D 122586 CDS NP_273264.1 15676133 902314 206324..207049 1 NC_003112.2 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 207049 aat 902314 aat Neisseria meningitidis MC58 leucyl/phenylalanyl-tRNA--protein transferase NP_273264.1 206324 D 122586 CDS NP_273265.1 15676134 902315 complement(207302..208333) 1 NC_003112.2 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 208333 gapA-1 902315 gapA-1 Neisseria meningitidis MC58 glyceraldehyde-3-phosphate dehydrogenase NP_273265.1 207302 R 122586 CDS NP_273266.1 15676135 902316 complement(208532..209371) 1 NC_003112.2 identified by similarity to EGAD:90639; match to protein family HMM PF00037; match to protein family HMM PF04060; match to protein family HMM TIGR01944; ferredoxin, 4Fe-4S type 209371 902316 NMB0208 Neisseria meningitidis MC58 ferredoxin, 4Fe-4S type NP_273266.1 208532 R 122586 CDS NP_273267.1 15676136 902317 209520..211496 1 NC_003112.2 identified by similarity to EGAD:29394; match to protein family HMM PF02080; match to protein family HMM PF02254; glutathione-regulated potassium-efflux system protein 211496 kefB 902317 kefB Neisseria meningitidis MC58 glutathione-regulated potassium-efflux system protein NP_273267.1 209520 D 122586 CDS NP_273268.1 15676137 902323 complement(212715..214100) 1 NC_003112.2 identified by similarity to GP:3402236; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; L-serine dehydratase 214100 sdaA 902323 sdaA Neisseria meningitidis MC58 L-serine dehydratase NP_273268.1 212715 R 122586 CDS NP_273269.1 15676138 902324 complement(214197..216587) 1 NC_003112.2 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 216587 gyrB 902324 gyrB Neisseria meningitidis MC58 DNA gyrase subunit B NP_273269.1 214197 R 122586 CDS NP_273270.1 15676139 902325 216743..217729 1 NC_003112.2 hypothetical protein 217729 902325 NMB0213 Neisseria meningitidis MC58 hypothetical protein NP_273270.1 216743 D 122586 CDS NP_273271.1 15676140 902326 217817..219853 1 NC_003112.2 identified by similarity to EGAD:28851; match to protein family HMM PF01432; oligopeptidase A 219853 prlC 902326 prlC Neisseria meningitidis MC58 oligopeptidase A NP_273271.1 217817 D 122586 CDS NP_273272.1 15676141 902327 complement(220476..221042) 1 NC_003112.2 identified by similarity to EGAD:32789; match to protein family HMM PF02659; hypothetical protein 221042 902327 NMB0215 Neisseria meningitidis MC58 hypothetical protein NP_273272.1 220476 R 122586 CDS NP_273273.1 15676142 902328 complement(221438..222952) 1 NC_003112.2 identified by similarity to EGAD:21555; match to protein family HMM PF00199; catalase 222952 kat 902328 kat Neisseria meningitidis MC58 catalase NP_273273.1 221438 R 122586 CDS NP_273274.1 15676143 902329 223300..224151 1 NC_003112.2 identified by similarity to EGAD:7711; match to protein family HMM PF00309; match to protein family HMM PF04552; match to protein family HMM PF04963; RNA polymerase sigma-54 factor RpoN 224151 902329 NMB0217 Neisseria meningitidis MC58 RNA polymerase sigma-54 factor RpoN NP_273274.1 223300 D 122586 CDS NP_273275.1 15676144 902330 complement(225071..226201) 1 NC_003112.2 identified by similarity to GP:3599932; match to protein family HMM PF00534; glycosyltransferase 226201 pglA 902330 pglA Neisseria meningitidis MC58 glycosyltransferase NP_273275.1 225071 R 122586 CDS NP_273276.1 15676145 902331 complement(226506..227753) 1 NC_003112.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 227753 fabF-1 902331 fabF-1 Neisseria meningitidis MC58 3-oxoacyl-ACP synthase NP_273276.1 226506 R 122586 CDS NP_273277.1 15676146 902332 complement(227909..228145) 1 NC_003112.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 228145 acpP 902332 acpP Neisseria meningitidis MC58 acyl carrier protein NP_273277.1 227909 R 122586 CDS NP_273278.1 15676147 902333 228377..229384 1 NC_003112.2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 229384 pyrD 902333 pyrD Neisseria meningitidis MC58 dihydroorotate dehydrogenase 2 NP_273278.1 228377 D 122586 CDS NP_273279.1 15676148 902334 229547..230020 1 NC_003112.2 hypothetical protein 230020 902334 NMB0222 Neisseria meningitidis MC58 hypothetical protein NP_273279.1 229547 D 122586 CDS NP_273281.1 15676150 902336 230563..233253 1 NC_003112.2 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 233253 glnE 902336 glnE Neisseria meningitidis MC58 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_273281.1 230563 D 122586 CDS NP_273282.1 15676151 902337 complement(233555..234520) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 234520 902337 NMB0225 Neisseria meningitidis MC58 IS30 family transposase NP_273282.1 233555 R 122586 CDS NP_273283.1 15676152 902338 complement(234785..235477) 1 NC_003112.2 identified by similarity to EGAD:106326; match to protein family HMM PF01863; hypothetical protein 235477 902338 NMB0226 Neisseria meningitidis MC58 hypothetical protein NP_273283.1 234785 R 122586 CDS NP_273284.1 15676153 902339 complement(235585..236778) 1 NC_003112.2 identified by similarity to EGAD:28718; hypothetical protein 236778 902339 NMB0227 Neisseria meningitidis MC58 hypothetical protein NP_273284.1 235585 R 122586 CDS NP_273285.1 15676154 902340 complement(236907..237644) 1 NC_003112.2 identified by similarity to EGAD:28719; match to protein family HMM PF03746; LamB/YcsF family protein 237644 902340 NMB0228 Neisseria meningitidis MC58 LamB/YcsF family protein NP_273285.1 236907 R 122586 CDS NP_273287.1 15676155 902341 complement(238556..239203) 1 NC_003112.2 identified by similarity to EGAD:28721; match to protein family HMM PF02682; match to protein family HMM TIGR00370; hypothetical protein 239203 902341 NMB0230 Neisseria meningitidis MC58 hypothetical protein NP_273287.1 238556 R 122586 CDS NP_273288.1 15676156 902342 complement(239259..239363) 1 NC_003112.2 hypothetical protein 239363 902342 NMB0231 Neisseria meningitidis MC58 hypothetical protein NP_273288.1 239259 R 122586 CDS NP_273289.1 15676157 902343 239387..241594 1 NC_003112.2 identified by similarity to EGAD:14237; match to protein family HMM PF00580; match to protein family HMM TIGR01075; DNA helicase II 241594 uvrD 902343 uvrD Neisseria meningitidis MC58 DNA helicase II NP_273289.1 239387 D 122586 CDS NP_273290.1 15676158 902344 241670..241771 1 NC_003112.2 hypothetical protein 241771 902344 NMB0233 Neisseria meningitidis MC58 hypothetical protein NP_273290.1 241670 D 122586 CDS NP_273291.1 15676159 902345 242118..242657 1 NC_003112.2 hypothetical protein 242657 902345 NMB0234 Neisseria meningitidis MC58 hypothetical protein NP_273291.1 242118 D 122586 CDS NP_273294.1 15676162 902348 complement(243183..243542) 1 NC_003112.2 hypothetical protein 243542 902348 NMB0237 Neisseria meningitidis MC58 hypothetical protein NP_273294.1 243183 R 122586 CDS NP_273295.1 15676163 902350 244058..244678 1 NC_003112.2 hypothetical protein 244678 902350 NMB0239 Neisseria meningitidis MC58 hypothetical protein NP_273295.1 244058 D 122586 CDS NP_273296.1 15676164 902351 244701..246152 1 NC_003112.2 hypothetical protein 246152 902351 NMB0240 Neisseria meningitidis MC58 hypothetical protein NP_273296.1 244701 D 122586 CDS NP_273297.1 15676165 902352 246614..246970 1 NC_003112.2 identified by similarity to GP:3025801; match to protein family HMM PF00507; NADH dehydrogenase I subunit A 246970 nuoA 902352 nuoA Neisseria meningitidis MC58 NADH dehydrogenase I subunit A NP_273297.1 246614 D 122586 CDS NP_273298.1 15676166 902353 246961..247443 1 NC_003112.2 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 247443 nuoB 902353 nuoB Neisseria meningitidis MC58 NADH dehydrogenase subunit B NP_273298.1 246961 D 122586 CDS NP_273299.1 15676167 902354 247456..248049 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 248049 nuoC 902354 nuoC Neisseria meningitidis MC58 NADH dehydrogenase subunit C NP_273299.1 247456 D 122586 CDS NP_273300.1 15676168 902355 248039..249295 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 249295 nuoD 902355 nuoD Neisseria meningitidis MC58 NADH dehydrogenase subunit D NP_273300.1 248039 D 122586 CDS NP_273301.1 15676169 902356 249295..249768 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 249768 nuoE 902356 nuoE Neisseria meningitidis MC58 NADH dehydrogenase subunit E NP_273301.1 249295 D 122586 CDS NP_273302.1 15676170 902357 250158..251459 1 NC_003112.2 identified by similarity to EGAD:102346; match to protein family HMM PF01512; match to protein family HMM TIGR01959; NADH dehydrogenase I subunit F 251459 nuoF 902357 nuoF Neisseria meningitidis MC58 NADH dehydrogenase I subunit F NP_273302.1 250158 D 122586 CDS NP_273303.1 15676171 902358 251459..251896 1 NC_003112.2 hypothetical protein 251896 902358 NMB0247 Neisseria meningitidis MC58 hypothetical protein NP_273303.1 251459 D 122586 CDS NP_273304.1 15676172 902359 252182..252421 1 NC_003112.2 identified by similarity to GP:2570056; match to protein family HMM PF01541; hypothetical protein 252421 902359 NMB0248 Neisseria meningitidis MC58 hypothetical protein NP_273304.1 252182 D 122586 CDS NP_273305.1 15676173 902360 252733..254994 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 254994 nuoG 902360 nuoG Neisseria meningitidis MC58 NADH dehydrogenase subunit G NP_273305.1 252733 D 122586 CDS NP_273306.1 15676174 902361 254997..256073 1 NC_003112.2 identified by similarity to EGAD:96512; match to protein family HMM PF00146; NADH dehydrogenase I subunit H 256073 nuoH 902361 nuoH Neisseria meningitidis MC58 NADH dehydrogenase I subunit H NP_273306.1 254997 D 122586 CDS NP_273307.1 15676175 902362 256154..256633 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 256633 nuoI 902362 nuoI Neisseria meningitidis MC58 NADH dehydrogenase subunit I NP_273307.1 256154 D 122586 CDS NP_273308.1 15676176 902363 256664..257371 1 NC_003112.2 hypothetical protein 257371 902363 NMB0252 Neisseria meningitidis MC58 hypothetical protein NP_273308.1 256664 D 122586 CDS NP_273309.1 15676177 902364 257407..258078 1 NC_003112.2 identified by similarity to EGAD:42978; match to protein family HMM PF00499; NADH dehydrogenase I subunit J 258078 nuoJ 902364 nuoJ Neisseria meningitidis MC58 NADH dehydrogenase I subunit J NP_273309.1 257407 D 122586 CDS NP_273310.1 15676178 902365 258075..258380 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 258380 nuoK 902365 nuoK Neisseria meningitidis MC58 NADH dehydrogenase subunit K NP_273310.1 258075 D 122586 CDS NP_273311.1 15676179 902366 258414..258989 1 NC_003112.2 identified by similarity to EGAD:27990; match to protein family HMM PF02661; cell filamentation protein Fic-like protein 258989 902366 NMB0255 Neisseria meningitidis MC58 cell filamentation protein Fic-like protein NP_273311.1 258414 D 122586 CDS NP_273312.1 15676180 902367 259113..259454 1 NC_003112.2 hypothetical protein 259454 902367 NMB0256 Neisseria meningitidis MC58 hypothetical protein NP_273312.1 259113 D 122586 CDS NP_273313.1 15676181 902368 259503..261527 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 261527 nuoL 902368 nuoL Neisseria meningitidis MC58 NADH dehydrogenase subunit L NP_273313.1 259503 D 122586 CDS NP_273314.1 15676182 902369 261623..263119 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 263119 nuoM 902369 nuoM Neisseria meningitidis MC58 NADH dehydrogenase subunit M NP_273314.1 261623 D 122586 CDS NP_273315.1 15676183 902370 263129..264571 1 NC_003112.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 264571 nuoN 902370 nuoN Neisseria meningitidis MC58 NADH dehydrogenase subunit N NP_273315.1 263129 D 122586 CDS NP_273317.1 15676185 902372 complement(265091..265870) 1 NC_003112.2 identified by similarity to EGAD:28427; match to protein family HMM PF00348; geranyltranstransferase 265870 ispA 902372 ispA Neisseria meningitidis MC58 geranyltranstransferase NP_273317.1 265091 R 122586 CDS NP_273318.1 15676186 902373 complement(265971..266195) 1 NC_003112.2 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 266195 xseB 902373 xseB Neisseria meningitidis MC58 exodeoxyribonuclease VII small subunit NP_273318.1 265971 R 122586 CDS NP_273319.1 15676187 902374 complement(266442..267365) 1 NC_003112.2 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 267365 902374 NMB0263 Neisseria meningitidis MC58 ribosome-associated GTPase NP_273319.1 266442 R 122586 CDS NP_273320.1 15676188 902375 complement(267370..269226) 1 NC_003112.2 identified by similarity to EGAD:28073; match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein 269226 902375 NMB0264 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273320.1 267370 R 122586 CDS NP_273321.1 15676189 902376 complement(269389..269973) 1 NC_003112.2 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 269973 ruvA 902376 ruvA Neisseria meningitidis MC58 Holliday junction DNA helicase RuvA NP_273321.1 269389 R 122586 CDS NP_273322.1 15676190 902377 complement(270055..270381) 1 NC_003112.2 identified by similarity to EGAD:107494; match to protein family HMM PF03413; hypothetical protein 270381 902377 NMB0266 Neisseria meningitidis MC58 hypothetical protein NP_273322.1 270055 R 122586 CDS NP_273323.1 15676191 902378 complement(270443..271162) 1 NC_003112.2 identified by similarity to EGAD:27846; match to protein family HMM PF03330; match to protein family HMM TIGR00413; hypothetical protein 271162 902378 NMB0267 Neisseria meningitidis MC58 hypothetical protein NP_273323.1 270443 R 122586 CDS NP_273324.1 15676192 902379 complement(271292..271756) 1 NC_003112.2 identified by similarity to EGAD:8165; match to protein family HMM PF00588; match to protein family HMM TIGR00185; RNA methyltransferase 271756 902379 NMB0268 Neisseria meningitidis MC58 RNA methyltransferase NP_273324.1 271292 R 122586 CDS NP_273325.1 15676193 902380 complement(271821..272546) 1 NC_003112.2 identified by similarity to EGAD:18112; competence protein 272546 902380 NMB0269 Neisseria meningitidis MC58 competence protein NP_273325.1 271821 R 122586 CDS NP_273326.1 15676194 902381 272545..273294 1 NC_003112.2 identified by similarity to EGAD:8656; match to protein family HMM PF00561; match to protein family HMM TIGR01738; bioH protein 273294 902381 NMB0270 Neisseria meningitidis MC58 bioH protein NP_273326.1 272545 D 122586 CDS NP_273327.1 15676195 902382 273291..274079 1 NC_003112.2 hypothetical protein 274079 902382 NMB0271 Neisseria meningitidis MC58 hypothetical protein NP_273327.1 273291 D 122586 CDS NP_273329.1 15676197 902384 274868..275293 1 NC_003112.2 hypothetical protein 275293 902384 NMB0273 Neisseria meningitidis MC58 hypothetical protein NP_273329.1 274868 D 122586 CDS NP_273330.1 15676198 902385 complement(275435..277735) 1 NC_003112.2 identified by similarity to GP:148221; match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389; ATP-dependent DNA helicase 277735 recQ 902385 recQ Neisseria meningitidis MC58 ATP-dependent DNA helicase NP_273330.1 275435 R 122586 CDS NP_273331.1 15676199 902386 complement(277800..278582) 1 NC_003112.2 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 278582 trpC 902386 trpC Neisseria meningitidis MC58 indole-3-glycerol phosphate synthase NP_273331.1 277800 R 122586 CDS NP_273332.1 15676200 902387 complement(278633..279589) 1 NC_003112.2 identified by similarity to EGAD:101623; hypothetical protein 279589 902387 NMB0276 Neisseria meningitidis MC58 hypothetical protein NP_273332.1 278633 R 122586 CDS NP_273333.1 15676201 902388 complement(279721..281262) 1 NC_003112.2 identified by similarity to EGAD:90808; match to protein family HMM PF03023; match to protein family HMM TIGR01695; virulence factor MviN 281262 mviN 902388 mviN Neisseria meningitidis MC58 virulence factor MviN NP_273333.1 279721 R 122586 CDS NP_273334.1 15676202 902389 281477..282175 1 NC_003112.2 identified by similarity to EGAD:98963; match to protein family HMM PF01323; thiol:disulfide interchange protein DsbA 282175 dsbA-1 902389 dsbA-1 Neisseria meningitidis MC58 thiol:disulfide interchange protein DsbA NP_273334.1 281477 D 122586 CDS NP_273335.1 15676203 902390 complement(282232..283236) 1 NC_003112.2 identified by similarity to EGAD:137413; hypothetical protein 283236 902390 NMB0279 Neisseria meningitidis MC58 hypothetical protein NP_273335.1 282232 R 122586 CDS NP_273336.1 15676204 902391 283438..285714 1 NC_003112.2 identified by similarity to EGAD:7471; match to protein family HMM PF04453; organic solvent tolerance protein 285714 902391 NMB0280 Neisseria meningitidis MC58 organic solvent tolerance protein NP_273336.1 283438 D 122586 CDS NP_273337.1 15676205 902392 285816..286862 1 NC_003112.2 identified by similarity to EGAD:7686; match to protein family HMM PF00639; peptidyl-prolyl cis-trans isomerase 286862 902392 NMB0281 Neisseria meningitidis MC58 peptidyl-prolyl cis-trans isomerase NP_273337.1 285816 D 122586 CDS NP_273338.1 15676206 902393 complement(288370..290250) 1 NC_003112.2 identified by similarity to EGAD:28723; match to protein family HMM PF00773; ribonuclease II-related protein 290250 902393 NMB0282 Neisseria meningitidis MC58 ribonuclease II-related protein NP_273338.1 288370 R 122586 CDS NP_273339.1 15676207 902394 290559..291191 1 NC_003112.2 identified by similarity to EGAD:155656; match to protein family HMM PF03641; match to protein family HMM TIGR00730; hypothetical protein 291191 902394 NMB0283 Neisseria meningitidis MC58 hypothetical protein NP_273339.1 290559 D 122586 CDS NP_273340.1 15676208 902395 291263..292633 1 NC_003112.2 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 292633 purB 902395 purB Neisseria meningitidis MC58 adenylosuccinate lyase NP_273340.1 291263 D 122586 CDS NP_273341.1 15676209 902397 complement(294874..295488) 1 NC_003112.2 identified by similarity to EGAD:5824; match to protein family HMM PF04391; hypothetical protein 295488 902397 NMB0286 Neisseria meningitidis MC58 hypothetical protein NP_273341.1 294874 R 122586 CDS NP_273342.1 15676210 902398 complement(295525..297675) 1 NC_003112.2 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 297675 dinG 902398 dinG Neisseria meningitidis MC58 ATP-dependent DNA helicase DinG NP_273342.1 295525 R 122586 CDS NP_273344.1 15676212 902401 complement(299360..300271) 1 NC_003112.2 identified by similarity to GP:1139588; match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator 300271 902401 NMB0290 Neisseria meningitidis MC58 transcriptional regulator NP_273344.1 299360 R 122586 CDS NP_273345.1 15676213 902402 300379..300777 1 NC_003112.2 identified by similarity to EGAD:160719; match to protein family HMM PF07681; hypothetical protein 300777 902402 NMB0291 Neisseria meningitidis MC58 hypothetical protein NP_273345.1 300379 D 122586 CDS NP_273346.1 15676214 902403 300826..301431 1 NC_003112.2 identified by similarity to EGAD:51135; hypothetical protein 301431 902403 NMB0292 Neisseria meningitidis MC58 hypothetical protein NP_273346.1 300826 D 122586 CDS NP_273347.1 15676215 902404 301617..303728 1 NC_003112.2 identified by similarity to EGAD:48295; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; TonB-dependent receptor 303728 902404 NMB0293 Neisseria meningitidis MC58 TonB-dependent receptor NP_273347.1 301617 D 122586 CDS NP_273348.1 15676216 902405 303843..304538 1 NC_003112.2 identified by similarity to GP:2707768; match to protein family HMM PF01323; thiol:disulfide interchange protein DsbA 304538 dsbA-2 902405 dsbA-2 Neisseria meningitidis MC58 thiol:disulfide interchange protein DsbA NP_273348.1 303843 D 122586 CDS NP_273349.1 15676217 902406 complement(304869..306239) 1 NC_003112.2 identified by similarity to EGAD:6526; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein 306239 ffh 902406 ffh Neisseria meningitidis MC58 signal recognition particle protein NP_273349.1 304869 R 122586 CDS NP_273350.1 15676218 902407 306459..307265 1 NC_003112.2 identified by similarity to GP:706856; match to protein family HMM PF01578; CcsA-like protein 307265 902407 NMB0296 Neisseria meningitidis MC58 CcsA-like protein NP_273350.1 306459 D 122586 CDS NP_273351.1 15676219 902408 307279..307377 1 NC_003112.2 hypothetical protein 307377 902408 NMB0297 Neisseria meningitidis MC58 hypothetical protein NP_273351.1 307279 D 122586 CDS NP_273353.1 15676221 902415 313104..313550 1 NC_003112.2 identified by similarity to EGAD:36757; match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; comEA-related protein 313550 902415 NMB0299 Neisseria meningitidis MC58 comEA-related protein NP_273353.1 313104 D 122586 CDS YP_008920704.1 566328917 902418 314275..314943 1 NC_003112.2 transposase 314943 902418 NMB0302 Neisseria meningitidis MC58 transposase YP_008920704.1 314275 D 122586 CDS NP_273357.1 15676225 902423 316410..317465 1 NC_003112.2 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 317465 aroG 902423 aroG Neisseria meningitidis MC58 phospho-2-dehydro-3-deoxyheptonate aldolase NP_273357.1 316410 D 122586 CDS NP_273358.1 15676226 902424 317533..318021 1 NC_003112.2 identified by similarity to EGAD:8105; match to protein family HMM PF00186; dihydrofolate reductase 318021 folA 902424 folA Neisseria meningitidis MC58 dihydrofolate reductase NP_273358.1 317533 D 122586 CDS NP_273359.1 15676227 902425 complement(318371..318847) 1 NC_003112.2 identified by similarity to EGAD:49208; match to protein family HMM PF01928; hypothetical protein 318847 902425 NMB0309 Neisseria meningitidis MC58 hypothetical protein NP_273359.1 318371 R 122586 CDS NP_273360.1 15676228 902426 complement(318859..319287) 1 NC_003112.2 identified by similarity to EGAD:89978; match to protein family HMM PF03653; hypothetical protein 319287 902426 NMB0310 Neisseria meningitidis MC58 hypothetical protein NP_273360.1 318859 R 122586 CDS NP_273361.1 15676229 902427 319399..319644 1 NC_003112.2 hypothetical protein 319644 902427 NMB0311 Neisseria meningitidis MC58 hypothetical protein NP_273361.1 319399 D 122586 CDS YP_008920705.1 566328918 902428 321328..323187 1 NC_003112.2 ATPase 323187 vapA 902428 vapA Neisseria meningitidis MC58 ATPase YP_008920705.1 321328 D 122586 CDS NP_273362.1 15676230 902429 323429..324895 1 NC_003112.2 identified by similarity to GP:3523136; match to protein family HMM PF04575; match to protein family HMM PF07719; hypothetical protein 324895 902429 NMB0313 Neisseria meningitidis MC58 hypothetical protein NP_273362.1 323429 D 122586 CDS NP_273363.1 15676231 902430 complement(325096..326064) 1 NC_003112.2 hypothetical protein 326064 902430 NMB0314 Neisseria meningitidis MC58 hypothetical protein NP_273363.1 325096 R 122586 CDS NP_273364.1 15676232 902431 326142..327434 1 NC_003112.2 identified by similarity to GP:146890; match to protein family HMM PF01551; hypothetical protein 327434 902431 NMB0315 Neisseria meningitidis MC58 hypothetical protein NP_273364.1 326142 D 122586 CDS NP_273365.1 15676233 902432 complement(327937..328623) 1 NC_003112.2 identified by similarity to EGAD:8792; match to protein family HMM PF02592; match to protein family HMM TIGR00697; hypothetical protein 328623 902432 NMB0316 Neisseria meningitidis MC58 hypothetical protein NP_273365.1 327937 R 122586 CDS NP_273366.1 15676234 902433 complement(328698..329171) 1 NC_003112.2 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 329171 902433 NMB0317 Neisseria meningitidis MC58 7-cyano-7-deazaguanine reductase NP_273366.1 328698 R 122586 CDS NP_273367.1 15676235 902434 329613..330767 1 NC_003112.2 identified by similarity to EGAD:20365; match to protein family HMM PF00529; fatty acid efflux system protein 330767 farA 902434 farA Neisseria meningitidis MC58 fatty acid efflux system protein NP_273367.1 329613 D 122586 CDS NP_273368.1 15676236 902435 330791..332317 1 NC_003112.2 identified by similarity to EGAD:19655; match to protein family HMM PF07690; match to protein family HMM TIGR00711; fatty acid efflux system protein 332317 farB 902435 farB Neisseria meningitidis MC58 fatty acid efflux system protein NP_273368.1 330791 D 122586 CDS NP_273370.1 15676238 902437 332567..332800 1 NC_003112.2 required for 70S ribosome assembly; 50S ribosomal protein L28 332800 rpmB 902437 rpmB Neisseria meningitidis MC58 50S ribosomal protein L28 NP_273370.1 332567 D 122586 CDS NP_273371.1 15676239 902438 332832..332987 1 NC_003112.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 332987 rpmG 902438 rpmG Neisseria meningitidis MC58 50S ribosomal protein L33 NP_273371.1 332832 D 122586 CDS NP_273372.1 15676240 902439 complement(333176..334360) 1 NC_003112.2 identified by similarity to EGAD:19694; match to protein family HMM PF01360; match to protein family HMM TIGR01988; hypothetical protein 334360 902439 NMB0323 Neisseria meningitidis MC58 hypothetical protein NP_273372.1 333176 R 122586 CDS NP_273373.1 15676241 902440 complement(334699..334971) 1 NC_003112.2 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 334971 rpmA 902440 rpmA Neisseria meningitidis MC58 50S ribosomal protein L27 NP_273373.1 334699 R 122586 CDS NP_273374.1 15676242 902441 complement(334996..335304) 1 NC_003112.2 identified by similarity to EGAD:23167; match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 335304 rplU 902441 rplU Neisseria meningitidis MC58 50S ribosomal protein L21 NP_273374.1 334996 R 122586 CDS NP_273375.1 15676243 902442 335528..336502 1 NC_003112.2 identified by similarity to EGAD:8604; match to protein family HMM PF00348; octaprenyl-diphosphate synthase 336502 ispB 902442 ispB Neisseria meningitidis MC58 octaprenyl-diphosphate synthase NP_273375.1 335528 D 122586 CDS NP_273377.1 15676244 902444 337073..337177 1 NC_003112.2 hypothetical protein 337177 902444 NMB0328 Neisseria meningitidis MC58 hypothetical protein NP_273377.1 337073 D 122586 CDS NP_273378.1 15676245 902445 337395..339071 1 NC_003112.2 identified by similarity to EGAD:21691; match to protein family HMM PF00437; match to protein family HMM PF05157; match to protein family HMM TIGR02538; type IV pilus assembly protein 339071 pilF 902445 pilF Neisseria meningitidis MC58 type IV pilus assembly protein NP_273378.1 337395 D 122586 CDS NP_273379.1 15676246 902446 complement(339156..339365) 1 NC_003112.2 identified by similarity to EGAD:36778; match to protein family HMM PF03884; hypothetical protein 339365 902446 NMB0330 Neisseria meningitidis MC58 hypothetical protein NP_273379.1 339156 R 122586 CDS NP_273380.1 15677989 903204 complement(339358..339990) 1 NC_003112.2 identified by similarity to EGAD:40831; match to protein family HMM PF01121; match to protein family HMM TIGR00152; kinase 339990 903204 NMB0331 Neisseria meningitidis MC58 kinase NP_273380.1 339358 R 122586 CDS NP_273381.1 15676247 902447 complement(339992..340852) 1 NC_003112.2 identified by similarity to EGAD:40757; match to protein family HMM PF01478; match to protein family HMM PF06750; type IV prepilin peptidase 340852 pilD 902447 pilD Neisseria meningitidis MC58 type IV prepilin peptidase NP_273381.1 339992 R 122586 CDS NP_273382.1 15676248 902448 complement(340926..342158) 1 NC_003112.2 identified by similarity to EGAD:40687; match to protein family HMM PF00482; pilus assembly protein PilG 342158 pilG 902448 pilG Neisseria meningitidis MC58 pilus assembly protein PilG NP_273382.1 340926 R 122586 CDS NP_273383.1 15676249 902449 342515..344158 1 NC_003112.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 344158 pgi 902449 pgi Neisseria meningitidis MC58 glucose-6-phosphate isomerase NP_273383.1 342515 D 122586 CDS NP_273384.1 15676250 902450 344368..345189 1 NC_003112.2 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 345189 dapD 902450 dapD Neisseria meningitidis MC58 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_273384.1 344368 D 122586 CDS NP_273385.1 15676251 902451 345344..346129 1 NC_003112.2 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 346129 fabI 902451 fabI Neisseria meningitidis MC58 enoyl-(acyl carrier protein) reductase NP_273385.1 345344 D 122586 CDS NP_273386.1 15676252 902452 complement(346373..347371) 1 NC_003112.2 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 347371 902452 NMB0337 Neisseria meningitidis MC58 branched-chain amino acid aminotransferase NP_273386.1 346373 R 122586 CDS NP_273387.2 566328915 902453 347639..347995 1 NC_003112.2 hypothetical protein 347995 902453 NMB0338 Neisseria meningitidis MC58 hypothetical protein NP_273387.2 347639 D 122586 CDS NP_273388.1 15676254 902454 348006..349175 1 NC_003112.2 identified by similarity to EGAD:28234; tetratricopeptide repeat protein 349175 902454 NMB0339 Neisseria meningitidis MC58 tetratricopeptide repeat protein NP_273388.1 348006 D 122586 CDS NP_273389.1 15676255 902455 349200..349616 1 NC_003112.2 identified by similarity to EGAD:134180; match to protein family HMM PF00903; match to protein family HMM TIGR00068; lactoylglutathione lyase 349616 gloA 902455 gloA Neisseria meningitidis MC58 lactoylglutathione lyase NP_273389.1 349200 D 122586 CDS NP_273390.1 15676256 902456 complement(349788..352415) 1 NC_003112.2 identified by similarity to GP:3413497; match to protein family HMM PF01476; tspA protein 352415 902456 NMB0341 Neisseria meningitidis MC58 tspA protein NP_273390.1 349788 R 122586 CDS NP_273391.1 15676257 902457 352621..353151 1 NC_003112.2 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 353151 ispZ 902457 ispZ Neisseria meningitidis MC58 intracellular septation protein A NP_273391.1 352621 D 122586 CDS NP_273392.1 15676258 902458 353166..353444 1 NC_003112.2 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 353444 902458 NMB0343 Neisseria meningitidis MC58 hypothetical protein NP_273392.1 353166 D 122586 CDS NP_273393.1 15676259 902459 353444..353722 1 NC_003112.2 identified by similarity to EGAD:21163; match to protein family HMM PF01722; BolA/YrbA family protein 353722 902459 NMB0344 Neisseria meningitidis MC58 BolA/YrbA family protein NP_273393.1 353444 D 122586 CDS NP_273394.1 15676260 902460 353771..354637 1 NC_003112.2 identified by similarity to EGAD:12394; cell-binding factor 354637 902460 NMB0345 Neisseria meningitidis MC58 cell-binding factor NP_273394.1 353771 D 122586 CDS NP_273395.1 15676261 902461 354708..355466 1 NC_003112.2 hypothetical protein 355466 902461 NMB0346 Neisseria meningitidis MC58 hypothetical protein NP_273395.1 354708 D 122586 CDS NP_273396.1 15676262 902462 355539..356030 1 NC_003112.2 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 356030 902462 NMB0347 Neisseria meningitidis MC58 D-tyrosyl-tRNA(Tyr) deacylase NP_273396.1 355539 D 122586 CDS NP_273397.1 15676263 902463 356061..357071 1 NC_003112.2 identified by similarity to EGAD:6786; match to protein family HMM PF01207; match to protein family HMM TIGR00742; tRNA-dihydrouridine synthase A 357071 902463 NMB0348 Neisseria meningitidis MC58 tRNA-dihydrouridine synthase A NP_273397.1 356061 D 122586 CDS NP_273398.1 15676264 902464 complement(357141..358028) 1 NC_003112.2 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 358028 902464 NMB0349 Neisseria meningitidis MC58 glutamyl-Q tRNA(Asp) synthetase NP_273398.1 357141 R 122586 CDS NP_273399.2 566328914 902465 complement(358316..358675) 1 NC_003112.2 hypothetical protein 358675 902465 NMB0350 Neisseria meningitidis MC58 hypothetical protein NP_273399.2 358316 R 122586 CDS NP_273400.1 15676266 902466 complement(358919..359974) 1 NC_003112.2 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 359974 tal 902466 tal Neisseria meningitidis MC58 transaldolase NP_273400.1 358919 R 122586 CDS NP_273401.1 15676267 902467 360071..361045 1 NC_003112.2 identified by similarity to EGAD:29719; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393; KpsF/GutQ family sugar isomerase 361045 902467 NMB0352 Neisseria meningitidis MC58 KpsF/GutQ family sugar isomerase NP_273401.1 360071 D 122586 CDS NP_273402.1 15676268 902468 361263..361799 1 NC_003112.2 identified by similarity to EGAD:155354; match to protein family HMM TIGR01662; match to protein family HMM TIGR01670; hypothetical protein 361799 902468 NMB0353 Neisseria meningitidis MC58 hypothetical protein NP_273402.1 361263 D 122586 CDS NP_273403.1 15676269 902469 361796..362377 1 NC_003112.2 hypothetical protein 362377 902469 NMB0354 Neisseria meningitidis MC58 hypothetical protein NP_273403.1 361796 D 122586 CDS NP_273404.1 15676270 902470 362358..362888 1 NC_003112.2 identified by similarity to EGAD:28154; match to protein family HMM PF03968; hypothetical protein 362888 902470 NMB0355 Neisseria meningitidis MC58 hypothetical protein NP_273404.1 362358 D 122586 CDS NP_273405.1 15676271 902471 362932..363696 1 NC_003112.2 identified by similarity to EGAD:139998; match to protein family HMM PF00005; ABC transporter ATP-binding protein 363696 902471 NMB0356 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273405.1 362932 D 122586 CDS NP_273406.1 15676272 902473 complement(364165..364866) 1 NC_003112.2 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 364866 mtgA 902473 mtgA Neisseria meningitidis MC58 monofunctional biosynthetic peptidoglycan transglycosylase NP_273406.1 364165 R 122586 CDS NP_273407.1 15676273 902474 complement(364869..365678) 1 NC_003112.2 identified by similarity to EGAD:142367; match to protein family HMM PF01488; match to protein family HMM TIGR00507; shikimate dehydrogenase 365678 aroE 902474 aroE Neisseria meningitidis MC58 shikimate dehydrogenase NP_273407.1 364869 R 122586 CDS NP_273408.1 15676274 902475 365978..367396 1 NC_003112.2 identified by similarity to EGAD:130497; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase 367396 glnA 902475 glnA Neisseria meningitidis MC58 glutamine synthetase NP_273408.1 365978 D 122586 CDS NP_273409.1 15676275 902476 367552..368835 1 NC_003112.2 identified by similarity to EGAD:147104; match to protein family HMM PF07690; match to protein family HMM TIGR00901; AmpG-like protein 368835 902476 NMB0360 Neisseria meningitidis MC58 AmpG-like protein NP_273409.1 367552 D 122586 CDS NP_273410.1 15676276 902477 368832..369107 1 NC_003112.2 identified by similarity to EGAD:147105; match to protein family HMM PF01541; hypothetical protein 369107 902477 NMB0361 Neisseria meningitidis MC58 hypothetical protein NP_273410.1 368832 D 122586 CDS NP_273411.1 15676277 902478 369213..369293 1 NC_003112.2 hypothetical protein 369293 902478 NMB0362 Neisseria meningitidis MC58 hypothetical protein NP_273411.1 369213 D 122586 CDS NP_273412.1 15676278 902479 369618..369755 1 NC_003112.2 hypothetical protein 369755 902479 NMB0363 Neisseria meningitidis MC58 hypothetical protein NP_273412.1 369618 D 122586 CDS NP_273413.1 15676279 902480 370096..370869 1 NC_003112.2 identified by similarity to EGAD:20116; match to protein family HMM PF06901; FrpC operon protein 370869 902480 NMB0364 Neisseria meningitidis MC58 FrpC operon protein NP_273413.1 370096 D 122586 CDS NP_273414.1 15677990 903203 370886..371161 1 NC_003112.2 identified by similarity to EGAD:18289; iron-regulated protein FrpC, truncation 371161 903203 NMB0365 Neisseria meningitidis MC58 iron-regulated protein FrpC, truncation NP_273414.1 370886 D 122586 CDS NP_273415.1 15676280 902481 complement(371248..372381) 1 NC_003112.2 hypothetical protein 372381 902481 NMB0366 Neisseria meningitidis MC58 hypothetical protein NP_273415.1 371248 R 122586 CDS NP_273416.1 15676281 902482 complement(372445..372831) 1 NC_003112.2 hypothetical protein 372831 902482 NMB0367 Neisseria meningitidis MC58 hypothetical protein NP_273416.1 372445 R 122586 CDS NP_273417.1 15676282 902483 complement(372900..373358) 1 NC_003112.2 hypothetical protein 373358 902483 NMB0368 Neisseria meningitidis MC58 hypothetical protein NP_273417.1 372900 R 122586 CDS NP_273418.1 15676283 902484 complement(373339..373728) 1 NC_003112.2 hypothetical protein 373728 902484 NMB0369 Neisseria meningitidis MC58 hypothetical protein NP_273418.1 373339 R 122586 CDS NP_273419.1 15676284 902485 complement(373860..374237) 1 NC_003112.2 hypothetical protein 374237 902485 NMB0370 Neisseria meningitidis MC58 hypothetical protein NP_273419.1 373860 R 122586 CDS NP_273420.1 15676285 902486 complement(374259..374666) 1 NC_003112.2 hypothetical protein 374666 902486 NMB0371 Neisseria meningitidis MC58 hypothetical protein NP_273420.1 374259 R 122586 CDS NP_273421.1 15676286 902487 complement(374672..375349) 1 NC_003112.2 hypothetical protein 375349 902487 NMB0372 Neisseria meningitidis MC58 hypothetical protein NP_273421.1 374672 R 122586 CDS NP_273422.1 15676287 902488 complement(375564..375923) 1 NC_003112.2 hypothetical protein 375923 902488 NMB0373 Neisseria meningitidis MC58 hypothetical protein NP_273422.1 375564 R 122586 CDS NP_273423.1 15676288 902489 complement(375926..377329) 1 NC_003112.2 identified by similarity to GP:4838555; match to protein family HMM PF06255; MafB-like protein 377329 902489 NMB0374 Neisseria meningitidis MC58 MafB-like protein NP_273423.1 375926 R 122586 CDS NP_273424.1 15676289 902490 complement(377333..378274) 1 NC_003112.2 identified by similarity to GP:4838554; mafA protein 378274 mafA-1 902490 mafA-1 Neisseria meningitidis MC58 mafA protein NP_273424.1 377333 R 122586 CDS NP_273425.1 15676290 902491 complement(378271..378387) 1 NC_003112.2 hypothetical protein 378387 902491 NMB0376 Neisseria meningitidis MC58 hypothetical protein NP_273425.1 378271 R 122586 CDS NP_273426.1 15676291 902492 complement(378394..379524) 1 NC_003112.2 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 379524 anmK 902492 anmK Neisseria meningitidis MC58 anhydro-N-acetylmuramic acid kinase NP_273426.1 378394 R 122586 CDS NP_273427.1 15676292 902493 379815..381389 1 NC_003112.2 identified by similarity to EGAD:160513; match to protein family HMM PF01384; phosphate permease 381389 902493 NMB0378 Neisseria meningitidis MC58 phosphate permease NP_273427.1 379815 D 122586 CDS NP_273428.1 15676293 902494 complement(381742..383163) 1 NC_003112.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 383163 hemN 902494 hemN Neisseria meningitidis MC58 coproporphyrinogen III oxidase NP_273428.1 381742 R 122586 CDS NP_273429.1 15676294 902495 383368..384102 1 NC_003112.2 identified by similarity to EGAD:41030; match to protein family HMM PF00027; match to protein family HMM PF00325; Crp/FNR family transcriptional regulator 384102 902495 NMB0380 Neisseria meningitidis MC58 Crp/FNR family transcriptional regulator NP_273429.1 383368 D 122586 CDS NP_273430.1 15676295 902496 complement(384215..385165) 1 NC_003112.2 identified by similarity to EGAD:32791; match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator CysB-like protein 385165 cysB 902496 cysB Neisseria meningitidis MC58 transcriptional regulator CysB-like protein NP_273430.1 384215 R 122586 CDS NP_273431.1 15676296 902497 385529..386257 1 NC_003112.2 identified by similarity to EGAD:10394; match to protein family HMM PF00691; outer membrane protein class 4 386257 rmpM 902497 rmpM Neisseria meningitidis MC58 outer membrane protein class 4 NP_273431.1 385529 D 122586 CDS NP_273434.1 15676299 902500 387108..388064 1 NC_003112.2 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 388064 thiL 902500 thiL Neisseria meningitidis MC58 thiamine monophosphate kinase NP_273434.1 387108 D 122586 CDS NP_273435.1 15676300 902501 388057..388542 1 NC_003112.2 identified by similarity to EGAD:28303; match to protein family HMM PF04608; phosphatidylglycerophosphatase A 388542 pgpA 902501 pgpA Neisseria meningitidis MC58 phosphatidylglycerophosphatase A NP_273435.1 388057 D 122586 CDS NP_273436.1 15676301 902502 complement(388602..390278) 1 NC_003112.2 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 390278 902502 NMB0387 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273436.1 388602 R 122586 CDS NP_273437.1 15676302 902503 390665..392020 1 NC_003112.2 identified by similarity to EGAD:62114; match to protein family HMM PF07690; sugar transporter 392020 902503 NMB0388 Neisseria meningitidis MC58 sugar transporter NP_273437.1 390665 D 122586 CDS NP_273438.1 15676303 902504 392024..393034 1 NC_003112.2 identified by similarity to EGAD:7305; match to protein family HMM PF01263; aldose 1-epimerase 393034 galM 902504 galM Neisseria meningitidis MC58 aldose 1-epimerase NP_273438.1 392024 D 122586 CDS NP_273439.1 15676304 902505 393268..395526 1 NC_003112.2 identified by similarity to GP:3724125; match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636; maltose phosphorylase 395526 mapA 902505 mapA Neisseria meningitidis MC58 maltose phosphorylase NP_273439.1 393268 D 122586 CDS NP_273440.1 15676305 902506 395539..396204 1 NC_003112.2 identified by similarity to EGAD:125152; match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01990; match to protein family HMM TIGR02009; beta-phosphoglucomutase 396204 pgmB 902506 pgmB Neisseria meningitidis MC58 beta-phosphoglucomutase NP_273440.1 395539 D 122586 CDS NP_273441.1 15676306 902507 complement(396382..397890) 1 NC_003112.2 identified by similarity to EGAD:18907; match to protein family HMM PF00890; match to protein family HMM TIGR00551; L-aspartate oxidase 397890 nadB 902507 nadB Neisseria meningitidis MC58 L-aspartate oxidase NP_273441.1 396382 R 122586 CDS NP_273442.1 15676307 902508 complement(397939..398274) 1 NC_003112.2 identified by similarity to GP:3647360; match to protein family HMM PF00893; multidrug resistance protein 398274 902508 NMB0393 Neisseria meningitidis MC58 multidrug resistance protein NP_273442.1 397939 R 122586 CDS NP_273443.1 15676308 902509 complement(398426..399538) 1 NC_003112.2 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 399538 nadA 902509 nadA Neisseria meningitidis MC58 quinolinate synthetase NP_273443.1 398426 R 122586 CDS NP_273444.1 15676309 902510 399740..400678 1 NC_003112.2 identified by similarity to EGAD:161074; hypothetical protein 400678 902510 NMB0395 Neisseria meningitidis MC58 hypothetical protein NP_273444.1 399740 D 122586 CDS NP_273445.1 15676310 902511 400896..401777 1 NC_003112.2 identified by similarity to EGAD:42463; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; nicotinate-nucleotide pyrophosphorylase 401777 nadC 902511 nadC Neisseria meningitidis MC58 nicotinate-nucleotide pyrophosphorylase NP_273445.1 400896 D 122586 CDS NP_273446.1 15676311 902512 401805..402092 1 NC_003112.2 hypothetical protein 402092 902512 NMB0397 Neisseria meningitidis MC58 hypothetical protein NP_273446.1 401805 D 122586 CDS NP_273447.1 15676312 902513 402184..402465 1 NC_003112.2 identified by similarity to EGAD:91779; match to protein family HMM PF01022; match to protein family HMM TIGR01199; ArsR family transcriptional regulator 402465 902513 NMB0398 Neisseria meningitidis MC58 ArsR family transcriptional regulator NP_273447.1 402184 D 122586 CDS NP_273448.1 15676313 902514 402525..403295 1 NC_003112.2 identified by similarity to EGAD:104607; match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 403295 xthA 902514 xthA Neisseria meningitidis MC58 exodeoxyribonuclease III NP_273448.1 402525 D 122586 CDS NP_273449.1 15677991 903202 404238..404810 1 NC_003112.2 identified by similarity to GP:3005554; transposase, truncated 404810 903202 NMB0400 Neisseria meningitidis MC58 transposase, truncated NP_273449.1 404238 D 122586 CDS NP_273450.1 15676314 902515 complement(405844..409449) 1 NC_003112.2 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 409449 putA 902515 putA Neisseria meningitidis MC58 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase NP_273450.1 405844 R 122586 CDS NP_273451.1 15676315 902516 complement(409698..411224) 1 NC_003112.2 identified by similarity to EGAD:13061; match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121; sodium/proline symporter 411224 putP 902516 putP Neisseria meningitidis MC58 sodium/proline symporter NP_273451.1 409698 R 122586 CDS NP_273452.1 15676316 902517 complement(411560..411652) 1 NC_003112.2 hypothetical protein 411652 902517 NMB0403 Neisseria meningitidis MC58 hypothetical protein NP_273452.1 411560 R 122586 CDS NP_273453.1 15676317 902518 411707..412027 1 NC_003112.2 identified by similarity to EGAD:36570; match to protein family HMM PF04380; hypothetical protein 412027 902518 NMB0404 Neisseria meningitidis MC58 hypothetical protein NP_273453.1 411707 D 122586 CDS NP_273454.1 15676318 902519 412041..413537 1 NC_003112.2 identified by similarity to EGAD:28125; match to protein family HMM PF01078; match to protein family HMM TIGR00368; competence protein ComM 413537 comM 902519 comM Neisseria meningitidis MC58 competence protein ComM NP_273454.1 412041 D 122586 CDS NP_273455.1 15676319 902520 413637..414506 1 NC_003112.2 identified by similarity to EGAD:40704; match to protein family HMM PF05036; match to protein family HMM TIGR02223; hypothetical protein 414506 902520 NMB0406 Neisseria meningitidis MC58 hypothetical protein NP_273455.1 413637 D 122586 CDS NP_273456.1 15676320 902521 414509..415153 1 NC_003112.2 identified by similarity to EGAD:98963; match to protein family HMM PF01323; thiol:disulfide interchange protein DsbA 415153 dsbA-3 902521 dsbA-3 Neisseria meningitidis MC58 thiol:disulfide interchange protein DsbA NP_273456.1 414509 D 122586 CDS NP_273457.1 15676321 902522 415186..416007 1 NC_003112.2 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 416007 bacA 902522 bacA Neisseria meningitidis MC58 undecaprenyl pyrophosphate phosphatase NP_273457.1 415186 D 122586 CDS NP_273458.1 15676322 902525 complement(416580..417791) 1 NC_003112.2 identified by similarity to EGAD:48967; match to protein family HMM PF02636; hypothetical protein 417791 902525 NMB0409 Neisseria meningitidis MC58 hypothetical protein NP_273458.1 416580 R 122586 CDS NP_273459.1 15676323 902526 418070..418525 1 NC_003112.2 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 418525 902526 NMB0410 Neisseria meningitidis MC58 cell division protein MraZ NP_273459.1 418070 D 122586 CDS NP_273460.1 15676324 902527 418522..419508 1 NC_003112.2 identified by similarity to EGAD:17026; match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 419508 mraW 902527 mraW Neisseria meningitidis MC58 S-adenosyl-methyltransferase MraW NP_273460.1 418522 D 122586 CDS NP_273461.1 15676325 902528 419499..419768 1 NC_003112.2 identified by similarity to EGAD:7061; match to protein family HMM TIGR02209; cell division protein FtsL-related protein 419768 902528 NMB0412 Neisseria meningitidis MC58 cell division protein FtsL-related protein NP_273461.1 419499 D 122586 CDS NP_273462.1 15676326 902529 419829..421574 1 NC_003112.2 identified by similarity to EGAD:40734; match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2 421574 penA 902529 penA Neisseria meningitidis MC58 penicillin-binding protein 2 NP_273462.1 419829 D 122586 CDS NP_273463.1 15676327 902530 421599..423077 1 NC_003112.2 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 423077 murE 902530 murE Neisseria meningitidis MC58 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_273463.1 421599 D 122586 CDS NP_273464.1 15676328 902532 424872..426239 1 NC_003112.2 identified by similarity to EGAD:28149; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01143; UDP-MurNAc-pentapeptide synthetase 426239 murF 902532 murF Neisseria meningitidis MC58 UDP-MurNAc-pentapeptide synthetase NP_273464.1 424872 D 122586 CDS NP_273465.1 15676329 902533 426242..426418 1 NC_003112.2 hypothetical protein 426418 902533 NMB0417 Neisseria meningitidis MC58 hypothetical protein NP_273465.1 426242 D 122586 CDS NP_273466.1 15676330 902534 426665..427747 1 NC_003112.2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 427747 mraY 902534 mraY Neisseria meningitidis MC58 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_273466.1 426665 D 122586 CDS NP_273467.1 15676331 902535 427873..428469 1 NC_003112.2 identified by similarity to EGAD:91374; match to protein family HMM PF03937; hypothetical protein 428469 902535 NMB0419 Neisseria meningitidis MC58 hypothetical protein NP_273467.1 427873 D 122586 CDS NP_273468.1 15676332 902536 428553..429890 1 NC_003112.2 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 429890 murD 902536 murD Neisseria meningitidis MC58 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_273468.1 428553 D 122586 CDS NP_273469.1 15676333 902537 430070..431341 1 NC_003112.2 identified by similarity to EGAD:28142; match to protein family HMM PF01098; cell division protein 431341 ftsW 902537 ftsW Neisseria meningitidis MC58 cell division protein NP_273469.1 430070 D 122586 CDS NP_273470.1 15676334 902538 431345..432412 1 NC_003112.2 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 432412 murG 902538 murG Neisseria meningitidis MC58 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_273470.1 431345 D 122586 CDS NP_273471.2 228970145 902539 432570..433976 1 NC_003112.2 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 433976 murC 902539 murC Neisseria meningitidis MC58 UDP-N-acetylmuramate--L-alanine ligase NP_273471.2 432570 D 122586 CDS NP_273472.1 15676336 902540 434089..435003 1 NC_003112.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 435003 ddl 902540 ddl Neisseria meningitidis MC58 D-alanine--D-alanine ligase NP_273472.1 434089 D 122586 CDS NP_273473.1 15676337 902541 435014..435721 1 NC_003112.2 identified by similarity to EGAD:21305; match to protein family HMM PF03799; cell division protein 435721 ftsQ 902541 ftsQ Neisseria meningitidis MC58 cell division protein NP_273473.1 435014 D 122586 CDS NP_273474.1 15676338 902542 435807..437051 1 NC_003112.2 identified by similarity to GP:2707899; match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein 437051 ftsA 902542 ftsA Neisseria meningitidis MC58 cell division protein NP_273474.1 435807 D 122586 CDS NP_273475.1 15676339 902543 437170..438348 1 NC_003112.2 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 438348 ftsZ 902543 ftsZ Neisseria meningitidis MC58 cell division protein FtsZ NP_273475.1 437170 D 122586 CDS NP_273476.1 15676340 902544 438487..439797 1 NC_003112.2 identified by similarity to EGAD:44500; match to protein family HMM PF00860; hypothetical protein 439797 902544 NMB0428 Neisseria meningitidis MC58 hypothetical protein NP_273476.1 438487 D 122586 CDS NP_273477.1 15676341 902545 440170..440274 1 NC_003112.2 hypothetical protein 440274 902545 NMB0429 Neisseria meningitidis MC58 hypothetical protein NP_273477.1 440170 D 122586 CDS NP_273478.1 15676342 902546 440420..441298 1 NC_003112.2 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 441298 prpB 902546 prpB Neisseria meningitidis MC58 2-methylisocitrate lyase NP_273478.1 440420 D 122586 CDS NP_273479.1 15676343 902547 441384..442538 1 NC_003112.2 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 442538 pprC 902547 pprC Neisseria meningitidis MC58 methylcitrate synthase NP_273479.1 441384 D 122586 CDS NP_273480.1 15676344 902548 442691..443479 1 NC_003112.2 identified by similarity to EGAD:24560; match to protein family HMM PF01925; hypothetical protein 443479 902548 NMB0432 Neisseria meningitidis MC58 hypothetical protein NP_273480.1 442691 D 122586 CDS NP_273481.1 15676345 902549 443557..446163 1 NC_003112.2 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 446163 acnA 902549 acnA Neisseria meningitidis MC58 aconitate hydratase NP_273481.1 443557 D 122586 CDS NP_273482.1 15676346 902550 446966..448135 1 NC_003112.2 identified by similarity to EGAD:91576; match to protein family HMM PF04303; match to protein family HMM TIGR02334; AcnD-accessory protein PrpF 448135 902550 NMB0434 Neisseria meningitidis MC58 AcnD-accessory protein PrpF NP_273482.1 446966 D 122586 CDS NP_273483.1 15676347 902551 448549..449748 1 NC_003112.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 449748 ackA-1 902551 ackA-1 Neisseria meningitidis MC58 acetate kinase NP_273483.1 448549 D 122586 CDS NP_273484.1 15676348 902552 450086..450727 1 NC_003112.2 identified by similarity to EGAD:28201; match to protein family HMM PF01300; match to protein family HMM TIGR00057; hypothetical protein 450727 902552 NMB0436 Neisseria meningitidis MC58 hypothetical protein NP_273484.1 450086 D 122586 CDS NP_273485.1 15676349 902553 complement(450854..451297) 1 NC_003112.2 identified by similarity to EGAD:9130; match to protein family HMM PF02082; match to protein family HMM TIGR00738; hypothetical protein 451297 902553 NMB0437 Neisseria meningitidis MC58 hypothetical protein NP_273485.1 450854 R 122586 CDS NP_273486.1 15676350 902554 451471..451839 1 NC_003112.2 hypothetical protein 451839 902554 NMB0438 Neisseria meningitidis MC58 hypothetical protein NP_273486.1 451471 D 122586 CDS NP_273487.1 15676351 902555 451884..453038 1 NC_003112.2 identified by similarity to EGAD:148199; match to protein family HMM PF05940; hypothetical protein 453038 902555 NMB0439 Neisseria meningitidis MC58 hypothetical protein NP_273487.1 451884 D 122586 CDS NP_273488.1 15676352 902556 complement(453095..453967) 1 NC_003112.2 identified by similarity to EGAD:156224; match to protein family HMM PF02153; prephenate dehydrogenase 453967 902556 NMB0440 Neisseria meningitidis MC58 prephenate dehydrogenase NP_273488.1 453095 R 122586 CDS NP_273489.1 15676353 902557 454052..454864 1 NC_003112.2 identified by similarity to EGAD:47743; match to protein family HMM PF00795; nitrilase 454864 902557 NMB0441 Neisseria meningitidis MC58 nitrilase NP_273489.1 454052 D 122586 CDS YP_008920706.1 566328919 902558 complement(454893..455567) 1 NC_003112.2 opacity protein 455567 902558 NMB0442 Neisseria meningitidis MC58 opacity protein YP_008920706.1 454893 R 122586 CDS NP_273490.1 15676354 902559 456464..457429 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 457429 902559 NMB0443 Neisseria meningitidis MC58 IS30 family transposase NP_273490.1 456464 D 122586 CDS NP_273491.1 15676355 902560 457987..458841 1 NC_003112.2 identified by similarity to EGAD:107888; match to protein family HMM PF00892; hypothetical protein 458841 902560 NMB0444 Neisseria meningitidis MC58 hypothetical protein NP_273491.1 457987 D 122586 CDS NP_273492.1 15676356 902561 459360..460592 1 NC_003112.2 identified by similarity to EGAD:28252; match to protein family HMM PF07690; match to protein family HMM TIGR00710; bicyclomycin resistance protein 460592 902561 NMB0445 Neisseria meningitidis MC58 bicyclomycin resistance protein NP_273492.1 459360 D 122586 CDS NP_273493.1 15676357 902562 460670..461758 1 NC_003112.2 identified by similarity to GP:4105530; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807; chorismate mutase 461758 pheA 902562 pheA Neisseria meningitidis MC58 chorismate mutase NP_273493.1 460670 D 122586 CDS NP_273494.1 15676358 902563 461795..462586 1 NC_003112.2 identified by similarity to EGAD:14344; match to protein family HMM PF02565; match to protein family HMM TIGR00613; DNA repair protein (recombination protein o) 462586 recO 902563 recO Neisseria meningitidis MC58 DNA repair protein (recombination protein o) NP_273494.1 461795 D 122586 CDS NP_273495.1 15676359 902564 462610..463338 1 NC_003112.2 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 463338 pdxJ 902564 pdxJ Neisseria meningitidis MC58 pyridoxine 5'-phosphate synthase NP_273495.1 462610 D 122586 CDS NP_273498.1 15676362 902567 464432..465199 1 NC_003112.2 hypothetical protein 465199 902567 NMB0451 Neisseria meningitidis MC58 hypothetical protein NP_273498.1 464432 D 122586 CDS NP_273499.1 15676363 902568 465399..465776 1 NC_003112.2 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 465776 acpS 902568 acpS Neisseria meningitidis MC58 4'-phosphopantetheinyl transferase NP_273499.1 465399 D 122586 CDS NP_273500.1 15676364 902569 465858..466667 1 NC_003112.2 identified by similarity to EGAD:29393; match to protein family HMM PF00293; mutT protein 466667 mutT 902569 mutT Neisseria meningitidis MC58 mutT protein NP_273500.1 465858 D 122586 CDS NP_273501.1 15676365 902570 466660..467082 1 NC_003112.2 hypothetical protein 467082 902570 NMB0454 Neisseria meningitidis MC58 hypothetical protein NP_273501.1 466660 D 122586 CDS NP_273502.1 15676366 902571 467131..468273 1 NC_003112.2 identified by similarity to EGAD:48783; match to protein family HMM PF01170; match to protein family HMM PF02926; hypothetical protein 468273 902571 NMB0455 Neisseria meningitidis MC58 hypothetical protein NP_273502.1 467131 D 122586 CDS NP_273503.1 15676367 902572 complement(468331..469581) 1 NC_003112.2 identified by similarity to EGAD:36618; match to protein family HMM PF01520; N-acetylmuramoyl-L-alanine amidase 469581 amiC 902572 amiC Neisseria meningitidis MC58 N-acetylmuramoyl-L-alanine amidase NP_273503.1 468331 R 122586 CDS NP_273504.1 15676368 902573 complement(469578..470039) 1 NC_003112.2 identified by similarity to EGAD:8343; match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein 470039 902573 NMB0457 Neisseria meningitidis MC58 hypothetical protein NP_273504.1 469578 R 122586 CDS NP_273505.1 15676369 902574 470241..471053 1 NC_003112.2 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 471053 murI 902574 murI Neisseria meningitidis MC58 glutamate racemase NP_273505.1 470241 D 122586 CDS NP_273506.1 15676370 902575 complement(472101..473210) 1 NC_003112.2 identified by similarity to EGAD:156656; match to protein family HMM PF02661; hypothetical protein 473210 902575 NMB0459 Neisseria meningitidis MC58 hypothetical protein NP_273506.1 472101 R 122586 CDS NP_273507.1 15676371 902576 475581..477719 1 NC_003112.2 identified by similarity to EGAD:40649; match to protein family HMM PF01298; transferrin-binding protein B 477719 tbp2 902576 tbp2 Neisseria meningitidis MC58 transferrin-binding protein B NP_273507.1 475581 D 122586 CDS NP_273508.1 15676372 902577 477806..480553 1 NC_003112.2 identified by similarity to EGAD:145507; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01776; match to protein family HMM TIGR01786; transferrin-binding protein 1 480553 tbp1 902577 tbp1 Neisseria meningitidis MC58 transferrin-binding protein 1 NP_273508.1 477806 D 122586 CDS NP_273509.1 15676373 902578 complement(481824..483203) 1 NC_003112.2 identified by similarity to EGAD:21832; match to protein family HMM PF01547; spermidine/putrescine ABC transporter substrate-binding protein 483203 potD-1 902578 potD-1 Neisseria meningitidis MC58 spermidine/putrescine ABC transporter substrate-binding protein NP_273509.1 481824 R 122586 CDS NP_273510.1 15676374 902579 483269..483532 1 NC_003112.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 483532 rpsT 902579 rpsT Neisseria meningitidis MC58 30S ribosomal protein S20 NP_273510.1 483269 D 122586 CDS NP_273511.1 15676375 902580 483693..484841 1 NC_003112.2 identified by similarity to EGAD:20225; match to protein family HMM PF02253; phospholipase A1 484841 902580 NMB0464 Neisseria meningitidis MC58 phospholipase A1 NP_273511.1 483693 D 122586 CDS NP_273512.1 15676376 902581 484984..485685 1 NC_003112.2 identified by similarity to EGAD:163702; match to protein family HMM PF04367; hypothetical protein 485685 902581 NMB0465 Neisseria meningitidis MC58 hypothetical protein NP_273512.1 484984 D 122586 CDS NP_273513.1 15676377 902582 485743..487551 1 NC_003112.2 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 487551 aspS 902582 aspS Neisseria meningitidis MC58 aspartyl-tRNA synthetase NP_273513.1 485743 D 122586 CDS NP_273514.1 15676378 902583 487702..487986 1 NC_003112.2 hypothetical protein 487986 902583 NMB0467 Neisseria meningitidis MC58 hypothetical protein NP_273514.1 487702 D 122586 CDS NP_273515.1 15676379 902584 488153..490045 1 NC_003112.2 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 490045 speA 902584 speA Neisseria meningitidis MC58 arginine decarboxylase NP_273515.1 488153 D 122586 CDS NP_273516.1 15676380 902585 490144..491067 1 NC_003112.2 catalyzes the formation of putrescine from agmatine; agmatinase 491067 speE 902585 speE Neisseria meningitidis MC58 agmatinase NP_273516.1 490144 D 122586 CDS NP_273517.1 15676381 902586 491265..492731 1 NC_003112.2 identified by similarity to EGAD:107946; match to protein family HMM PF00939; match to protein family HMM TIGR00785; C4-dicarboxylate transporter 492731 902586 NMB0470 Neisseria meningitidis MC58 C4-dicarboxylate transporter NP_273517.1 491265 D 122586 CDS NP_273518.1 15676382 902587 complement(492938..494014) 1 NC_003112.2 identified by similarity to EGAD:91634; match to protein family HMM PF03734; hypothetical protein 494014 902587 NMB0471 Neisseria meningitidis MC58 hypothetical protein NP_273518.1 492938 R 122586 CDS NP_273519.1 15676383 902588 494237..495379 1 NC_003112.2 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 495379 bioF 902588 bioF Neisseria meningitidis MC58 8-amino-7-oxononanoate synthase NP_273519.1 494237 D 122586 CDS NP_273520.1 15676384 902589 495389..496036 1 NC_003112.2 identified by similarity to EGAD:28546; match to protein family HMM PF04301; hypothetical protein 496036 902589 NMB0473 Neisseria meningitidis MC58 hypothetical protein NP_273520.1 495389 D 122586 CDS NP_273521.1 15676385 902590 496024..496806 1 NC_003112.2 identified by similarity to EGAD:28545; match to protein family HMM TIGR02072; biotin synthesis protein BioC 496806 902590 NMB0474 Neisseria meningitidis MC58 biotin synthesis protein BioC NP_273521.1 496024 D 122586 CDS NP_273522.1 15676386 902591 497071..498462 1 NC_003112.2 hypothetical protein 498462 902591 NMB0475 Neisseria meningitidis MC58 hypothetical protein NP_273522.1 497071 D 122586 CDS NP_273523.1 15676387 902592 498465..499562 1 NC_003112.2 hypothetical protein 499562 902592 NMB0476 Neisseria meningitidis MC58 hypothetical protein NP_273523.1 498465 D 122586 CDS NP_273524.1 15676388 902593 499574..500110 1 NC_003112.2 identified by similarity to EGAD:156531; match to protein family HMM PF03029; match to protein family HMM TIGR00231; hypothetical protein 500110 902593 NMB0477 Neisseria meningitidis MC58 hypothetical protein NP_273524.1 499574 D 122586 CDS NP_273525.1 15676389 902594 500112..500756 1 NC_003112.2 hypothetical protein 500756 902594 NMB0478 Neisseria meningitidis MC58 hypothetical protein NP_273525.1 500112 D 122586 CDS NP_273526.1 15676390 902595 500779..501138 1 NC_003112.2 identified by similarity to EGAD:156541; match to protein family HMM PF03259; hypothetical protein 501138 902595 NMB0479 Neisseria meningitidis MC58 hypothetical protein NP_273526.1 500779 D 122586 CDS NP_273527.1 15676391 902597 complement(501806..502201) 1 NC_003112.2 identified by similarity to GP:3758871; TspB-like protein 502201 902597 NMB0480 Neisseria meningitidis MC58 TspB-like protein NP_273527.1 501806 R 122586 CDS NP_273528.1 15676392 902598 complement(502185..502517) 1 NC_003112.2 hypothetical protein 502517 902598 NMB0481 Neisseria meningitidis MC58 hypothetical protein NP_273528.1 502185 R 122586 CDS NP_273529.1 15676393 902599 complement(502630..502908) 1 NC_003112.2 hypothetical protein 502908 902599 NMB0482 Neisseria meningitidis MC58 hypothetical protein NP_273529.1 502630 R 122586 CDS NP_273530.1 15676394 902600 complement(502915..503199) 1 NC_003112.2 hypothetical protein 503199 902600 NMB0483 Neisseria meningitidis MC58 hypothetical protein NP_273530.1 502915 R 122586 CDS NP_273531.1 15676395 902601 complement(503207..503404) 1 NC_003112.2 hypothetical protein 503404 902601 NMB0484 Neisseria meningitidis MC58 hypothetical protein NP_273531.1 503207 R 122586 CDS NP_273532.1 15676396 902602 complement(503409..503699) 1 NC_003112.2 hypothetical protein 503699 902602 NMB0485 Neisseria meningitidis MC58 hypothetical protein NP_273532.1 503409 R 122586 CDS YP_008920707.1 566328920 902603 complement(503744..504778) 1 NC_003112.2 replication initiation factor 504778 902603 NMB0486 Neisseria meningitidis MC58 replication initiation factor YP_008920707.1 503744 R 122586 CDS NP_273534.1 15676398 902605 complement(505314..505808) 1 NC_003112.2 hypothetical protein 505808 902605 NMB0488 Neisseria meningitidis MC58 hypothetical protein NP_273534.1 505314 R 122586 CDS NP_273537.1 15676401 902608 complement(508309..508752) 1 NC_003112.2 hypothetical protein 508752 902608 NMB0491 Neisseria meningitidis MC58 hypothetical protein NP_273537.1 508309 R 122586 CDS NP_273538.1 15676402 902609 complement(509068..509391) 1 NC_003112.2 hypothetical protein 509391 902609 NMB0492 Neisseria meningitidis MC58 hypothetical protein NP_273538.1 509068 R 122586 CDS NP_273539.1 15676403 902610 complement(509391..517502) 1 NC_003112.2 identified by similarity to GP:2623258; match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01731; match to protein family HMM TIGR01901; hemagglutinin/hemolysin-like protein 517502 902610 NMB0493 Neisseria meningitidis MC58 hemagglutinin/hemolysin-like protein NP_273539.1 509391 R 122586 CDS NP_273540.1 15677992 903201 complement(517630..518115) 1 NC_003112.2 identified by similarity to SP:P03005; DNA helicase, truncation 518115 903201 NMB0494 Neisseria meningitidis MC58 DNA helicase, truncation NP_273540.1 517630 R 122586 CDS NP_273541.1 15676404 902611 complement(518212..519195) 1 NC_003112.2 identified by similarity to EGAD:24391; match to protein family HMM PF01051; replication protein 519195 902611 NMB0495 Neisseria meningitidis MC58 replication protein NP_273541.1 518212 R 122586 CDS NP_273542.1 15676405 902612 519142..520821 1 NC_003112.2 identified by similarity to EGAD:10212; match to protein family HMM PF03865; hemolysin activator-like protein 520821 902612 NMB0496 Neisseria meningitidis MC58 hemolysin activator-like protein NP_273542.1 519142 D 122586 CDS NP_273543.2 77358708 902613 520930..526866 1 NC_003112.2 identified by similarity to EGAD:131268; match to protein family HMM PF04829; match to protein family HMM PF04830; match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01901; hemagglutinin/hemolysin-like protein 526866 902613 NMB0497 Neisseria meningitidis MC58 hemagglutinin/hemolysin-like protein NP_273543.2 520930 D 122586 CDS NP_273544.1 15676407 902614 526873..527382 1 NC_003112.2 hypothetical protein 527382 902614 NMB0498 Neisseria meningitidis MC58 hypothetical protein NP_273544.1 526873 D 122586 CDS NP_273545.1 15676408 902615 527508..529130 1 NC_003112.2 hypothetical protein 529130 902615 NMB0499 Neisseria meningitidis MC58 hypothetical protein NP_273545.1 527508 D 122586 CDS NP_273546.1 15676409 902616 529139..529516 1 NC_003112.2 hypothetical protein 529516 902616 NMB0500 Neisseria meningitidis MC58 hypothetical protein NP_273546.1 529139 D 122586 CDS NP_273547.1 15676410 902617 529794..530168 1 NC_003112.2 hypothetical protein 530168 902617 NMB0501 Neisseria meningitidis MC58 hypothetical protein NP_273547.1 529794 D 122586 CDS NP_273548.1 15676411 902618 530203..532155 1 NC_003112.2 hypothetical protein 532155 902618 NMB0502 Neisseria meningitidis MC58 hypothetical protein NP_273548.1 530203 D 122586 CDS NP_273549.1 15676412 902619 532171..532602 1 NC_003112.2 hypothetical protein 532602 902619 NMB0503 Neisseria meningitidis MC58 hypothetical protein NP_273549.1 532171 D 122586 CDS NP_273552.2 566328913 902622 532747..535248 1 NC_003112.2 hypothetical protein 535248 902622 NMB0506 Neisseria meningitidis MC58 hypothetical protein NP_273552.2 532747 D 122586 CDS NP_273553.1 15676416 902623 535245..535733 1 NC_003112.2 hypothetical protein 535733 902623 NMB0507 Neisseria meningitidis MC58 hypothetical protein NP_273553.1 535245 D 122586 CDS NP_273554.1 15676417 902624 535920..536192 1 NC_003112.2 hypothetical protein 536192 902624 NMB0508 Neisseria meningitidis MC58 hypothetical protein NP_273554.1 535920 D 122586 CDS NP_273555.1 15676418 902625 536372..537154 1 NC_003112.2 hypothetical protein 537154 902625 NMB0509 Neisseria meningitidis MC58 hypothetical protein NP_273555.1 536372 D 122586 CDS NP_273556.1 15676419 902626 537173..537436 1 NC_003112.2 hypothetical protein 537436 902626 NMB0510 Neisseria meningitidis MC58 hypothetical protein NP_273556.1 537173 D 122586 CDS NP_273557.1 15676420 902627 537543..539465 1 NC_003112.2 hypothetical protein 539465 902627 NMB0511 Neisseria meningitidis MC58 hypothetical protein NP_273557.1 537543 D 122586 CDS NP_273558.1 15676421 902628 539474..539896 1 NC_003112.2 hypothetical protein 539896 902628 NMB0512 Neisseria meningitidis MC58 hypothetical protein NP_273558.1 539474 D 122586 CDS NP_273559.1 15676422 902629 539933..540334 1 NC_003112.2 hypothetical protein 540334 902629 NMB0513 Neisseria meningitidis MC58 hypothetical protein NP_273559.1 539933 D 122586 CDS NP_273562.1 15676425 902632 541079..542014 1 NC_003112.2 hypothetical protein 542014 902632 NMB0516 Neisseria meningitidis MC58 hypothetical protein NP_273562.1 541079 D 122586 CDS NP_273567.1 15676430 902637 543529..543987 1 NC_003112.2 hypothetical protein 543987 902637 NMB0521 Neisseria meningitidis MC58 hypothetical protein NP_273567.1 543529 D 122586 CDS NP_273568.1 15677993 903200 543995..544120 1 NC_003112.2 identified by similarity to EGAD:162585; transposase, truncated 544120 903200 NMB0522 Neisseria meningitidis MC58 transposase, truncated NP_273568.1 543995 D 122586 CDS NP_273569.1 15676431 902639 complement(544508..545728) 1 NC_003112.2 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; this protein contains a C-terminal extension of unknown function; ribonuclease BN/unknown domain fusion protein 545728 rbn 902639 rbn Neisseria meningitidis MC58 ribonuclease BN/unknown domain fusion protein NP_273569.1 544508 R 122586 CDS NP_273570.1 15676432 902640 546273..546932 1 NC_003112.2 identified by similarity to EGAD:28204; match to protein family HMM PF06508; match to protein family HMM TIGR00364; aluminum resistance protein 546932 902640 NMB0525 Neisseria meningitidis MC58 aluminum resistance protein NP_273570.1 546273 D 122586 CDS NP_273571.1 15676433 902641 546960..547478 1 NC_003112.2 hypothetical protein 547478 902641 NMB0526 Neisseria meningitidis MC58 hypothetical protein NP_273571.1 546960 D 122586 CDS NP_273572.1 15676434 902642 547485..547907 1 NC_003112.2 identified by similarity to EGAD:28193; match to protein family HMM PF01242; 6-pyruvoyl tetrahydrobiopterin synthase 547907 902642 NMB0527 Neisseria meningitidis MC58 6-pyruvoyl tetrahydrobiopterin synthase NP_273572.1 547485 D 122586 CDS NP_273573.1 15676435 902643 548176..548547 1 NC_003112.2 identified by similarity to EGAD:12599; match to protein family HMM PF06993; hypothetical protein 548547 902643 NMB0528 Neisseria meningitidis MC58 hypothetical protein NP_273573.1 548176 D 122586 CDS NP_273574.1 15676436 902644 548544..549182 1 NC_003112.2 identified by similarity to EGAD:28192; match to protein family HMM PF04055; hypothetical protein 549182 902644 NMB0529 Neisseria meningitidis MC58 hypothetical protein NP_273574.1 548544 D 122586 CDS NP_273575.1 15676437 902646 complement(549821..550906) 1 NC_003112.2 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 550906 902646 NMB0530 Neisseria meningitidis MC58 beta-hexosaminidase NP_273575.1 549821 R 122586 CDS NP_273576.1 15676438 902647 complement(550963..552483) 1 NC_003112.2 identified by similarity to EGAD:28568; match to protein family HMM PF03553; hypothetical protein 552483 902647 NMB0531 Neisseria meningitidis MC58 hypothetical protein NP_273576.1 550963 R 122586 CDS NP_273577.1 15677994 903199 complement(552685..554184) 1 NC_003112.2 identified by similarity to EGAD:16686; match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; protease Do 554184 htrA 903199 htrA Neisseria meningitidis MC58 protease Do NP_273577.1 552685 R 122586 CDS NP_273578.1 15676439 902648 complement(554322..554951) 1 NC_003112.2 identified by similarity to EGAD:18451; match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III 554951 nth 902648 nth Neisseria meningitidis MC58 endonuclease III NP_273578.1 554322 R 122586 CDS NP_273579.1 15676440 902649 complement(554997..555410) 1 NC_003112.2 identified by similarity to EGAD:29125; hypothetical protein 555410 902649 NMB0534 Neisseria meningitidis MC58 hypothetical protein NP_273579.1 554997 R 122586 CDS NP_273580.1 15676441 902650 555943..557223 1 NC_003112.2 identified by similarity to EGAD:41134; match to protein family HMM PF07690; match to protein family HMM TIGR01272; glucose/galactose transporter 557223 gluP 902650 gluP Neisseria meningitidis MC58 glucose/galactose transporter NP_273580.1 555943 D 122586 CDS NP_273581.1 15676442 902651 557514..558893 1 NC_003112.2 identified by similarity to EGAD:15401; match to protein family HMM PF03553; match to protein family HMM TIGR00931; Na+/H+ antiporter 558893 902651 NMB0536 Neisseria meningitidis MC58 Na+/H+ antiporter NP_273581.1 557514 D 122586 CDS NP_273582.1 15676443 902652 complement(559022..559846) 1 NC_003112.2 identified by similarity to EGAD:91441; match to protein family HMM PF00571; match to protein family HMM PF03471; hypothetical protein 559846 902652 NMB0537 Neisseria meningitidis MC58 hypothetical protein NP_273582.1 559022 R 122586 CDS NP_273583.1 15676444 902653 complement(559854..560363) 1 NC_003112.2 identified by similarity to EGAD:91444; match to protein family HMM PF02130; match to protein family HMM TIGR00043; hypothetical protein 560363 902653 NMB0538 Neisseria meningitidis MC58 hypothetical protein NP_273583.1 559854 R 122586 CDS NP_273584.1 15676445 902654 560482..561417 1 NC_003112.2 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 561417 hemC 902654 hemC Neisseria meningitidis MC58 porphobilinogen deaminase NP_273584.1 560482 D 122586 CDS NP_273585.1 15676446 902655 complement(561821..563014) 1 NC_003112.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 563014 aspC 902655 aspC Neisseria meningitidis MC58 aromatic amino acid aminotransferase NP_273585.1 561821 R 122586 CDS NP_273586.1 15676447 902656 complement(563096..563593) 1 NC_003112.2 hypothetical protein 563593 902656 NMB0541 Neisseria meningitidis MC58 hypothetical protein NP_273586.1 563096 R 122586 CDS NP_273587.1 15676448 902657 563709..563912 1 NC_003112.2 hypothetical protein 563912 902657 NMB0542 Neisseria meningitidis MC58 hypothetical protein NP_273587.1 563709 D 122586 CDS NP_273588.1 15676449 902658 complement(564081..565667) 1 NC_003112.2 identified by similarity to EGAD:28220; match to protein family HMM PF02652; match to protein family HMM TIGR00795; L-lactate permease 565667 902658 NMB0543 Neisseria meningitidis MC58 L-lactate permease NP_273588.1 564081 R 122586 CDS NP_273589.1 15676450 902659 complement(565936..566658) 1 NC_003112.2 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 566658 902659 NMB0544 Neisseria meningitidis MC58 UDP-2,3-diacylglucosamine hydrolase NP_273589.1 565936 R 122586 CDS NP_273590.1 15676451 902660 566907..570392 1 NC_003112.2 identified by similarity to EGAD:37839; match to protein family HMM PF02463; match to protein family HMM PF02483; match to protein family HMM TIGR02168; hypothetical protein 570392 902660 NMB0545 Neisseria meningitidis MC58 hypothetical protein NP_273590.1 566907 D 122586 CDS NP_273591.2 161353786 902661 complement(570557..571597) 1 NC_003112.2 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 571597 adhP 902661 adhP Neisseria meningitidis MC58 alcohol dehydrogenase NP_273591.2 570557 R 122586 CDS NP_273592.1 15676453 902662 complement(571886..572275) 1 NC_003112.2 identified by similarity to EGAD:20241; match to protein family HMM PF07963; match to protein family HMM TIGR02532; type IV pilin protein 572275 902662 NMB0547 Neisseria meningitidis MC58 type IV pilin protein NP_273592.1 571886 R 122586 CDS NP_273593.1 15676454 902663 572501..573679 1 NC_003112.2 identified by similarity to EGAD:91761; match to protein family HMM PF00529; match to protein family HMM TIGR01730; AcrA/AcrE family protein 573679 902663 NMB0548 Neisseria meningitidis MC58 AcrA/AcrE family protein NP_273593.1 572501 D 122586 CDS NP_273594.1 15676455 902664 573745..575679 1 NC_003112.2 identified by similarity to EGAD:91762; match to protein family HMM PF00005; match to protein family HMM PF02687; ABC transporter ATP-binding protein 575679 ybjZ 902664 ybjZ Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273594.1 573745 D 122586 CDS NP_273595.1 15676456 902665 complement(576092..576874) 1 NC_003112.2 identified by similarity to GP:3135321; thiol:disulfide interchange protein DsbC 576874 dsbC 902665 dsbC Neisseria meningitidis MC58 thiol:disulfide interchange protein DsbC NP_273595.1 576092 R 122586 CDS NP_273596.1 15676457 902666 577012..579201 1 NC_003112.2 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 579201 priA 902666 priA Neisseria meningitidis MC58 primosome assembly protein PriA NP_273596.1 577012 D 122586 CDS NP_273597.1 15676458 902667 complement(579248..580321) 1 NC_003112.2 hypothetical protein 580321 902667 NMB0552 Neisseria meningitidis MC58 hypothetical protein NP_273597.1 579248 R 122586 CDS NP_273598.1 15676459 902669 complement(582560..584488) 1 NC_003112.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 584488 dnaK 902669 dnaK Neisseria meningitidis MC58 molecular chaperone DnaK NP_273598.1 582560 R 122586 CDS NP_273599.1 15676460 902670 complement(584696..584968) 1 NC_003112.2 hypothetical protein 584968 902670 NMB0555 Neisseria meningitidis MC58 hypothetical protein NP_273599.1 584696 R 122586 CDS NP_273600.1 15676461 902671 585156..585842 1 NC_003112.2 identified by similarity to EGAD:140303; match to protein family HMM PF00717; repressor protein 585842 902671 NMB0556 Neisseria meningitidis MC58 repressor protein NP_273600.1 585156 D 122586 CDS NP_273601.1 15676462 902672 585974..586312 1 NC_003112.2 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 586312 902672 NMB0557 Neisseria meningitidis MC58 iron-sulfur cluster insertion protein ErpA NP_273601.1 585974 D 122586 CDS NP_273602.1 15676463 902673 586472..586936 1 NC_003112.2 hypothetical protein 586936 902673 NMB0558 Neisseria meningitidis MC58 hypothetical protein NP_273602.1 586472 D 122586 CDS NP_273603.1 15676464 902674 586971..588482 1 NC_003112.2 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 588482 ubiB 902674 ubiB Neisseria meningitidis MC58 ubiquinone biosynthesis protein UbiB NP_273603.1 586971 D 122586 CDS NP_273604.1 15676465 902675 complement(588839..589657) 1 NC_003112.2 identified by similarity to EGAD:29240; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172; serine acetyltransferase 589657 cysE 902675 cysE Neisseria meningitidis MC58 serine acetyltransferase NP_273604.1 588839 R 122586 CDS NP_273605.1 15676466 902676 589841..590419 1 NC_003112.2 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 590419 grpE 902676 grpE Neisseria meningitidis MC58 heat shock protein GrpE NP_273605.1 589841 D 122586 CDS NP_273606.1 15676467 902677 complement(590696..590911) 1 NC_003112.2 identified by similarity to EGAD:28820; match to protein family HMM PF04400; hypothetical protein 590911 902677 NMB0562 Neisseria meningitidis MC58 hypothetical protein NP_273606.1 590696 R 122586 CDS NP_273607.1 15676468 902678 complement(590937..591992) 1 NC_003112.2 identified by similarity to EGAD:28819; match to protein family HMM PF02424; thiamine biosynthesis lipoprotein ApbE 591992 apbE 902678 apbE Neisseria meningitidis MC58 thiamine biosynthesis lipoprotein ApbE NP_273607.1 590937 R 122586 CDS NP_273608.1 15676469 902679 complement(592145..593362) 1 NC_003112.2 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 593362 nqrF 902679 nqrF Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit F NP_273608.1 592145 R 122586 CDS NP_273609.1 15676470 902680 complement(593376..593969) 1 NC_003112.2 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 593969 nqrE 902680 nqrE Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit E NP_273609.1 593376 R 122586 CDS NP_273610.1 15676471 902681 complement(593973..594599) 1 NC_003112.2 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 594599 nqrD 902681 nqrD Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit D NP_273610.1 593973 R 122586 CDS NP_273611.1 15676472 902682 complement(594599..595375) 1 NC_003112.2 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 595375 nqrC 902682 nqrC Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit C NP_273611.1 594599 R 122586 CDS NP_273612.1 15676473 902683 complement(595368..596600) 1 NC_003112.2 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 596600 nqrB 902683 nqrB Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit B NP_273612.1 595368 R 122586 CDS NP_273613.1 15676474 902684 complement(596603..597946) 1 NC_003112.2 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 597946 nqrA 902684 nqrA Neisseria meningitidis MC58 Na(+)-translocating NADH-quinone reductase subunit A NP_273613.1 596603 R 122586 CDS NP_273614.1 15676475 902685 complement(598296..599717) 1 NC_003112.2 hypothetical protein 599717 902685 NMB0570 Neisseria meningitidis MC58 hypothetical protein NP_273614.1 598296 R 122586 CDS NP_273615.1 15676476 902686 complement(600078..600437) 1 NC_003112.2 identified by similarity to EGAD:29947; match to protein family HMM PF04304; hypothetical protein 600437 902686 NMB0571 Neisseria meningitidis MC58 hypothetical protein NP_273615.1 600078 R 122586 CDS NP_273616.1 15676477 902687 complement(600434..601039) 1 NC_003112.2 hypothetical protein 601039 902687 NMB0572 Neisseria meningitidis MC58 hypothetical protein NP_273616.1 600434 R 122586 CDS NP_273617.1 15676478 902688 complement(601086..601649) 1 NC_003112.2 identified by similarity to GP:1272513; match to protein family HMM PF01037; AsnC family transcriptional regulator 601649 902688 NMB0573 Neisseria meningitidis MC58 AsnC family transcriptional regulator NP_273617.1 601086 R 122586 CDS NP_273618.1 15676479 902689 602079..603179 1 NC_003112.2 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 603179 gcvT 902689 gcvT Neisseria meningitidis MC58 glycine cleavage system aminomethyltransferase T NP_273618.1 602079 D 122586 CDS NP_273619.1 15676480 902690 603341..603727 1 NC_003112.2 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 603727 gcvH 902690 gcvH Neisseria meningitidis MC58 glycine cleavage system protein H NP_273619.1 603341 D 122586 CDS NP_273620.1 15676481 902691 603879..605126 1 NC_003112.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 605126 hemA 902691 hemA Neisseria meningitidis MC58 glutamyl-tRNA reductase NP_273620.1 603879 D 122586 CDS NP_273621.1 15676482 902692 605402..605974 1 NC_003112.2 identified by similarity to GP:2935358; NosR-like protein 605974 902692 NMB0577 Neisseria meningitidis MC58 NosR-like protein NP_273621.1 605402 D 122586 CDS NP_273622.1 15676483 902693 606028..607062 1 NC_003112.2 identified by similarity to EGAD:35473; match to protein family HMM PF05048; copper ABC transporter substrate-binding protein 607062 nosD 902693 nosD Neisseria meningitidis MC58 copper ABC transporter substrate-binding protein NP_273622.1 606028 D 122586 CDS NP_273623.1 15676484 902694 607120..607740 1 NC_003112.2 identified by similarity to EGAD:35474; match to protein family HMM PF00005; copper ABC transporter ATP-binding protein 607740 nosF 902694 nosF Neisseria meningitidis MC58 copper ABC transporter ATP-binding protein NP_273623.1 607120 D 122586 CDS NP_273624.1 15676485 902695 607879..608373 1 NC_003112.2 identified by similarity to GP:2177177; match to protein family HMM PF05573; protein disulfide isomerase NosL 608373 902695 NMB0580 Neisseria meningitidis MC58 protein disulfide isomerase NosL NP_273624.1 607879 D 122586 CDS NP_273625.1 15676486 902696 complement(608461..610122) 1 NC_003112.2 identified by similarity to EGAD:128939; match to protein family HMM PF05187; electron transfer flavoprotein-ubiquinone oxidoreductase 610122 902696 NMB0581 Neisseria meningitidis MC58 electron transfer flavoprotein-ubiquinone oxidoreductase NP_273625.1 608461 R 122586 CDS NP_273626.1 15676487 902697 complement(610252..610794) 1 NC_003112.2 identified by similarity to GP:2909665; match to protein family HMM PF03412; bacteriocin resistance protein 610794 902697 NMB0582 Neisseria meningitidis MC58 bacteriocin resistance protein NP_273626.1 610252 R 122586 CDS NP_273627.1 15676488 902698 complement(612020..612688) 1 NC_003112.2 identified by similarity to GP:4102010; IS1016C2 transposase 612688 902698 NMB0583 Neisseria meningitidis MC58 IS1016C2 transposase NP_273627.1 612020 R 122586 CDS NP_273628.1 15676489 902699 613279..614094 1 NC_003112.2 identified by similarity to EGAD:20116; match to protein family HMM PF06901; FrpC operon protein 614094 902699 NMB0584 Neisseria meningitidis MC58 FrpC operon protein NP_273628.1 613279 D 122586 CDS NP_273629.1 15676490 902700 614111..618019 1 NC_003112.2 identified by similarity to EGAD:18289; match to protein family HMM PF00353; iron-regulated protein FrpA 618019 902700 NMB0585 Neisseria meningitidis MC58 iron-regulated protein FrpA NP_273629.1 614111 D 122586 CDS NP_273630.1 15676491 902701 complement(618299..619213) 1 NC_003112.2 identified by similarity to EGAD:16475; match to protein family HMM PF01297; adhesin 619213 902701 NMB0586 Neisseria meningitidis MC58 adhesin NP_273630.1 618299 R 122586 CDS NP_273631.1 15676492 902702 complement(619290..620165) 1 NC_003112.2 identified by similarity to EGAD:15708; match to protein family HMM PF00950; membrane protein 620165 902702 NMB0587 Neisseria meningitidis MC58 membrane protein NP_273631.1 619290 R 122586 CDS NP_273632.1 15676493 902703 complement(620189..620944) 1 NC_003112.2 identified by similarity to EGAD:153448; match to protein family HMM PF00005; ABC transporter ATP-binding protein 620944 902703 NMB0588 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_273632.1 620189 R 122586 CDS NP_273633.1 15676494 902704 complement(621235..621600) 1 NC_003112.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 621600 rplS 902704 rplS Neisseria meningitidis MC58 50S ribosomal protein L19 NP_273633.1 621235 R 122586 CDS NP_273634.1 15676495 902705 complement(621616..622365) 1 NC_003112.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 622365 trmD 902705 trmD Neisseria meningitidis MC58 tRNA (guanine-N(1)-)-methyltransferase NP_273634.1 621616 R 122586 CDS NP_273635.1 15676496 902706 complement(622365..622874) 1 NC_003112.2 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 622874 rimM 902706 rimM Neisseria meningitidis MC58 16S rRNA-processing protein RimM NP_273635.1 622365 R 122586 CDS NP_273636.1 15676497 902707 complement(622890..623135) 1 NC_003112.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 623135 rpsP 902707 rpsP Neisseria meningitidis MC58 30S ribosomal protein S16 NP_273636.1 622890 R 122586 CDS NP_273637.1 15676498 902708 complement(623180..625606) 1 NC_003112.2 identified by similarity to EGAD:37591; match to protein family HMM PF00583; match to protein family HMM PF02629; hypothetical protein 625606 902708 NMB0593 Neisseria meningitidis MC58 hypothetical protein NP_273637.1 623180 R 122586 CDS NP_273638.1 15676499 902709 complement(625724..627130) 1 NC_003112.2 identified by similarity to GP:208252; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 627130 902709 NMB0594 Neisseria meningitidis MC58 sensor histidine kinase NP_273638.1 625724 R 122586 CDS NP_273639.1 15676500 902710 complement(627144..627821) 1 NC_003112.2 identified by similarity to EGAD:40657; match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 627821 902710 NMB0595 Neisseria meningitidis MC58 DNA-binding response regulator NP_273639.1 627144 R 122586 CDS NP_273640.1 15676501 902711 complement(628011..629825) 1 NC_003112.2 hypothetical protein 629825 902711 NMB0596 Neisseria meningitidis MC58 hypothetical protein NP_273640.1 628011 R 122586 CDS NP_273641.1 15676502 902712 complement(629815..630168) 1 NC_003112.2 hypothetical protein 630168 902712 NMB0597 Neisseria meningitidis MC58 hypothetical protein NP_273641.1 629815 R 122586 CDS NP_273642.1 15676503 902713 complement(630177..630785) 1 NC_003112.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 630785 902713 NMB0598 Neisseria meningitidis MC58 Maf-like protein NP_273642.1 630177 R 122586 CDS NP_273643.1 15676504 902714 complement(630838..631608) 1 NC_003112.2 identified by similarity to EGAD:35952; match to protein family HMM PF00902; match to protein family HMM TIGR00945; hypothetical protein 631608 902714 NMB0599 Neisseria meningitidis MC58 hypothetical protein NP_273643.1 630838 R 122586 CDS NP_273644.1 15676505 902715 complement(631622..632308) 1 NC_003112.2 hypothetical protein 632308 902715 NMB0600 Neisseria meningitidis MC58 hypothetical protein NP_273644.1 631622 R 122586 CDS NP_273645.1 15677995 903198 complement(632312..632515) 1 NC_003112.2 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 632515 tatA 903198 tatA Neisseria meningitidis MC58 twin arginine translocase A NP_273645.1 632312 R 122586 CDS NP_273646.1 15676506 902716 complement(632562..632885) 1 NC_003112.2 identified by similarity to EGAD:149280; match to protein family HMM PF01230; HitA protein 632885 hitA 902716 hitA Neisseria meningitidis MC58 HitA protein NP_273646.1 632562 R 122586 CDS NP_273647.1 15676507 902717 complement(632957..633280) 1 NC_003112.2 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 633280 hisE 902717 hisE Neisseria meningitidis MC58 phosphoribosyl-ATP pyrophosphatase NP_273647.1 632957 R 122586 CDS NP_273648.1 15676508 902718 complement(633421..634485) 1 NC_003112.2 identified by similarity to EGAD:107561; match to protein family HMM PF00107; alcohol dehydrogenase 634485 902718 NMB0604 Neisseria meningitidis MC58 alcohol dehydrogenase NP_273648.1 633421 R 122586 CDS NP_273649.1 15676509 902719 complement(635034..636143) 1 NC_003112.2 identified by similarity to EGAD:48895; match to protein family HMM PF00850; histone deacetylase 636143 902719 NMB0605 Neisseria meningitidis MC58 histone deacetylase NP_273649.1 635034 R 122586 CDS NP_273650.1 15676510 902720 636271..636537 1 NC_003112.2 identified by similarity to EGAD:166065; match to protein family HMM PF02699; match to protein family HMM TIGR00739; hypothetical protein 636537 902720 NMB0606 Neisseria meningitidis MC58 hypothetical protein NP_273650.1 636271 D 122586 CDS NP_273651.1 15676511 902721 636746..638602 1 NC_003112.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 638602 secD 902721 secD Neisseria meningitidis MC58 preprotein translocase subunit SecD NP_273651.1 636746 D 122586 CDS NP_273652.1 15676512 902722 638606..639541 1 NC_003112.2 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 639541 secF 902722 secF Neisseria meningitidis MC58 preprotein translocase subunit SecF NP_273652.1 638606 D 122586 CDS NP_273653.1 15676513 902723 639764..640033 1 NC_003112.2 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 640033 rpsO 902723 rpsO Neisseria meningitidis MC58 30S ribosomal protein S15 NP_273653.1 639764 D 122586 CDS NP_273654.1 15676514 902724 640279..641538 1 NC_003112.2 identified by similarity to EGAD:19034; match to protein family HMM PF00005; match to protein family HMM TIGR01187; spermidine/putrescine ABC transporter ATP-binding protein 641538 potA-1 902724 potA-1 Neisseria meningitidis MC58 spermidine/putrescine ABC transporter ATP-binding protein NP_273654.1 640279 D 122586 CDS NP_273655.1 15676515 902725 641554..642519 1 NC_003112.2 identified by similarity to EGAD:21628; match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 642519 potB 902725 potB Neisseria meningitidis MC58 spermidine/putrescine ABC transporter permease NP_273655.1 641554 D 122586 CDS NP_273656.1 15676516 902726 642519..643406 1 NC_003112.2 identified by similarity to EGAD:18692; match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 643406 potC 902726 potC Neisseria meningitidis MC58 spermidine/putrescine ABC transporter permease NP_273656.1 642519 D 122586 CDS NP_273657.1 15676517 902727 643428..643535 1 NC_003112.2 hypothetical protein 643535 902727 NMB0613 Neisseria meningitidis MC58 hypothetical protein NP_273657.1 643428 D 122586 CDS NP_273658.1 15676518 902728 643532..644827 1 NC_003112.2 identified by similarity to EGAD:29135; oxidoreductase 644827 902728 NMB0614 Neisseria meningitidis MC58 oxidoreductase NP_273658.1 643532 D 122586 CDS NP_273659.1 15676519 902729 complement(645072..646376) 1 NC_003112.2 identified by similarity to GP:3136068; match to protein family HMM PF00909; match to protein family HMM TIGR00836; ammonium transporter AmtB 646376 902729 NMB0615 Neisseria meningitidis MC58 ammonium transporter AmtB NP_273659.1 645072 R 122586 CDS NP_273661.1 15676520 902730 complement(647614..648873) 1 NC_003112.2 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 648873 rho 902730 rho Neisseria meningitidis MC58 transcription termination factor Rho NP_273661.1 647614 R 122586 CDS NP_273662.1 15676521 902731 complement(649093..651477) 1 NC_003112.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 651477 ppsA 902731 ppsA Neisseria meningitidis MC58 phosphoenolpyruvate synthase NP_273662.1 649093 R 122586 CDS NP_273663.1 15676522 902732 651889..652710 1 NC_003112.2 identified by similarity to EGAD:7555; match to protein family HMM PF03618; hypothetical protein 652710 902732 NMB0619 Neisseria meningitidis MC58 hypothetical protein NP_273663.1 651889 D 122586 CDS NP_273664.1 15676523 902733 complement(652949..653611) 1 NC_003112.2 identified by similarity to EGAD:155362; match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 653611 pgp 902733 pgp Neisseria meningitidis MC58 phosphoglycolate phosphatase NP_273664.1 652949 R 122586 CDS NP_273665.1 15676524 902734 complement(653649..654476) 1 NC_003112.2 identified by similarity to EGAD:28731; match to protein family HMM PF04305; hypothetical protein 654476 902734 NMB0621 Neisseria meningitidis MC58 hypothetical protein NP_273665.1 653649 R 122586 CDS NP_273666.1 15676525 902735 654903..655526 1 NC_003112.2 identified by similarity to GP:4063381; match to protein family HMM PF03548; match to protein family HMM TIGR00547; outer membrane lipoprotein carrier protein 655526 lolA 902735 lolA Neisseria meningitidis MC58 outer membrane lipoprotein carrier protein NP_273666.1 654903 D 122586 CDS NP_273667.1 15676526 902736 655799..656938 1 NC_003112.2 identified by similarity to EGAD:21832; match to protein family HMM PF01547; spermidine/putrescine ABC transporter substrate-binding protein 656938 potD-2 902736 potD-2 Neisseria meningitidis MC58 spermidine/putrescine ABC transporter substrate-binding protein NP_273667.1 655799 D 122586 CDS NP_273668.1 15676527 902738 658333..658863 1 NC_003112.2 identified by similarity to EGAD:29917; match to protein family HMM PF00132; hypothetical protein 658863 902738 NMB0625 Neisseria meningitidis MC58 hypothetical protein NP_273668.1 658333 D 122586 CDS NP_273669.1 15676528 902739 complement(659238..660833) 1 NC_003112.2 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 660833 prfC 902739 prfC Neisseria meningitidis MC58 peptide chain release factor 3 NP_273669.1 659238 R 122586 CDS NP_273670.1 15676529 902740 complement(660940..661335) 1 NC_003112.2 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 661335 hisI 902740 hisI Neisseria meningitidis MC58 phosphoribosyl-AMP cyclohydrolase NP_273670.1 660940 R 122586 CDS NP_273671.1 15676530 902741 complement(661366..662133) 1 NC_003112.2 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 662133 hisF 902741 hisF Neisseria meningitidis MC58 imidazole glycerol phosphate synthase subunit HisF NP_273671.1 661366 R 122586 CDS NP_273672.1 15676531 902742 complement(662146..662883) 1 NC_003112.2 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 662883 hisA 902742 hisA Neisseria meningitidis MC58 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_273672.1 662146 R 122586 CDS NP_273673.1 15676532 902743 complement(662916..663554) 1 NC_003112.2 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 663554 hisH 902743 hisH Neisseria meningitidis MC58 imidazole glycerol phosphate synthase subunit HisH NP_273673.1 662916 R 122586 CDS NP_273674.1 15676533 902744 complement(663685..665187) 1 NC_003112.2 identified by similarity to EGAD:28215; match to protein family HMM PF01515; match to protein family HMM TIGR00651; phosphate acetyltransferase 665187 902744 NMB0631 Neisseria meningitidis MC58 phosphate acetyltransferase NP_273674.1 663685 R 122586 CDS NP_273675.1 15677997 903196 complement(665372..666430) 1 NC_003112.2 identified by similarity to EGAD:40676; match to protein family HMM PF00005; iron(III) ABC transporter ATP-binding protein 666430 fbpC 903196 fbpC Neisseria meningitidis MC58 iron(III) ABC transporter ATP-binding protein NP_273675.1 665372 R 122586 CDS NP_273676.1 15677998 903195 complement(666451..667968) 1 NC_003112.2 identified by similarity to EGAD:40675; match to protein family HMM PF00528; iron(III) ABC transporter permease 667968 fbpB 903195 fbpB Neisseria meningitidis MC58 iron(III) ABC transporter permease NP_273676.1 666451 R 122586 CDS NP_273677.1 15676534 902745 complement(668036..669031) 1 NC_003112.2 identified by similarity to EGAD:7909; match to protein family HMM PF01547; iron ABC transporter substrate-binding protein 669031 fbpA 902745 fbpA Neisseria meningitidis MC58 iron ABC transporter substrate-binding protein NP_273677.1 668036 R 122586 CDS NP_273678.1 15676535 902746 complement(669318..670283) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; transposase IS30 670283 902746 NMB0635 Neisseria meningitidis MC58 transposase IS30 NP_273678.1 669318 R 122586 CDS NP_273680.1 15676537 902748 complement(670888..672264) 1 NC_003112.2 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 672264 argH 902748 argH Neisseria meningitidis MC58 argininosuccinate lyase NP_273680.1 670888 R 122586 CDS NP_273681.1 15676538 902749 complement(672283..673152) 1 NC_003112.2 identified by similarity to EGAD:153516; match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 673152 galU 902749 galU Neisseria meningitidis MC58 UTP-glucose-1-phosphate uridylyltransferase NP_273681.1 672283 R 122586 CDS NP_273682.1 15676539 902750 complement(673180..673779) 1 NC_003112.2 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 673779 902750 NMB0639 Neisseria meningitidis MC58 deoxyribonucleotide triphosphate pyrophosphatase NP_273682.1 673180 R 122586 CDS NP_273683.1 15676540 902751 complement(673772..674005) 1 NC_003112.2 hypothetical protein 674005 902751 NMB0640 Neisseria meningitidis MC58 hypothetical protein NP_273683.1 673772 R 122586 CDS NP_273684.1 15676541 902752 complement(674113..674646) 1 NC_003112.2 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 674646 ppa 902752 ppa Neisseria meningitidis MC58 inorganic pyrophosphatase NP_273684.1 674113 R 122586 CDS NP_273685.1 15676542 902753 complement(674747..675205) 1 NC_003112.2 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 675205 ntpA 902753 ntpA Neisseria meningitidis MC58 dATP pyrophosphohydrolase NP_273685.1 674747 R 122586 CDS NP_273686.1 15676543 902755 675650..677476 1 NC_003112.2 identified by similarity to GP:4838555; match to protein family HMM PF06255; MafB-like protein 677476 902755 NMB0643 Neisseria meningitidis MC58 MafB-like protein NP_273686.1 675650 D 122586 CDS NP_273687.1 15676544 902756 677479..677943 1 NC_003112.2 hypothetical protein 677943 902756 NMB0644 Neisseria meningitidis MC58 hypothetical protein NP_273687.1 677479 D 122586 CDS NP_273688.1 15676545 902758 678326..678613 1 NC_003112.2 identified by similarity to EGAD:16283; match to protein family HMM PF01337; ribonuclease inhibitor barstar 678613 902758 NMB0646 Neisseria meningitidis MC58 ribonuclease inhibitor barstar NP_273688.1 678326 D 122586 CDS NP_273690.1 15676547 902760 680393..680815 1 NC_003112.2 hypothetical protein 680815 902760 NMB0648 Neisseria meningitidis MC58 hypothetical protein NP_273690.1 680393 D 122586 CDS NP_273691.1 15676548 902761 681006..681230 1 NC_003112.2 hypothetical protein 681230 902761 NMB0649 Neisseria meningitidis MC58 hypothetical protein NP_273691.1 681006 D 122586 CDS NP_273692.1 15676549 902762 681203..681622 1 NC_003112.2 hypothetical protein 681622 902762 NMB0650 Neisseria meningitidis MC58 hypothetical protein NP_273692.1 681203 D 122586 CDS NP_273693.1 15676550 902763 681723..682112 1 NC_003112.2 hypothetical protein 682112 902763 NMB0651 Neisseria meningitidis MC58 hypothetical protein NP_273693.1 681723 D 122586 CDS NP_273694.1 15676551 902764 682235..683176 1 NC_003112.2 identified by similarity to GP:4838554; mafA protein 683176 mafA-2 902764 mafA-2 Neisseria meningitidis MC58 mafA protein NP_273694.1 682235 D 122586 CDS NP_273695.1 15676552 902765 683180..684448 1 NC_003112.2 identified by similarity to GP:4838555; match to protein family HMM PF06255; MafB-like protein 684448 902765 NMB0653 Neisseria meningitidis MC58 MafB-like protein NP_273695.1 683180 D 122586 CDS NP_273696.1 15676553 902766 684451..684768 1 NC_003112.2 hypothetical protein 684768 902766 NMB0654 Neisseria meningitidis MC58 hypothetical protein NP_273696.1 684451 D 122586 CDS NP_273697.1 15676554 902767 684903..685610 1 NC_003112.2 hypothetical protein 685610 902767 NMB0655 Neisseria meningitidis MC58 hypothetical protein NP_273697.1 684903 D 122586 CDS NP_273698.1 15676555 902768 685636..685965 1 NC_003112.2 hypothetical protein 685965 902768 NMB0656 Neisseria meningitidis MC58 hypothetical protein NP_273698.1 685636 D 122586 CDS NP_273701.1 15676558 902771 686382..686783 1 NC_003112.2 hypothetical protein 686783 902771 NMB0659 Neisseria meningitidis MC58 hypothetical protein NP_273701.1 686382 D 122586 CDS NP_273702.1 15676559 902772 686965..687354 1 NC_003112.2 hypothetical protein 687354 902772 NMB0660 Neisseria meningitidis MC58 hypothetical protein NP_273702.1 686965 D 122586 CDS NP_273703.2 566328903 903194 complement(687395..688852) 1 NC_003112.2 identified by similarity to EGAD:13777; match to protein family HMM TIGR00668; bis(5'-nucleosyl)-tetraphosphatase 688852 903194 NMB0661 Neisseria meningitidis MC58 bis(5'-nucleosyl)-tetraphosphatase NP_273703.2 687395 R 122586 CDS NP_273704.1 15676560 902773 complement(689773..690162) 1 NC_003112.2 identified by similarity to EGAD:30582; match to protein family HMM PF01042; match to protein family HMM TIGR00004; ribonuclease 690162 902773 NMB0662 Neisseria meningitidis MC58 ribonuclease NP_273704.1 689773 R 122586 CDS NP_273705.1 15676561 902774 complement(690298..690822) 1 NC_003112.2 identified by similarity to EGAD:137514; match to protein family HMM PF02462; outer membrane protein 690822 nspA 902774 nspA Neisseria meningitidis MC58 outer membrane protein NP_273705.1 690298 R 122586 CDS NP_273707.1 15676563 902776 complement(691407..692582) 1 NC_003112.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 692582 902776 NMB0665 Neisseria meningitidis MC58 coproporphyrinogen III oxidase NP_273707.1 691407 R 122586 CDS NP_273708.1 15676564 902777 complement(692639..695164) 1 NC_003112.2 identified by similarity to EGAD:14652; match to protein family HMM PF00533; match to protein family HMM PF01653; match to protein family HMM PF03119; match to protein family HMM PF03120; match to protein family HMM TIGR00575; DNA ligase 695164 ligA-1 902777 ligA-1 Neisseria meningitidis MC58 DNA ligase NP_273708.1 692639 R 122586 CDS NP_273709.1 15676565 902778 complement(695312..696598) 1 NC_003112.2 hypothetical protein 696598 902778 NMB0667 Neisseria meningitidis MC58 hypothetical protein NP_273709.1 695312 R 122586 CDS NP_273710.1 15676566 902779 complement(696816..697388) 1 NC_003112.2 identified by similarity to EGAD:17713; match to protein family HMM PF01510; N-acetyl-anhydromuranmyl-L-alanine amidase 697388 ampD 902779 ampD Neisseria meningitidis MC58 N-acetyl-anhydromuranmyl-L-alanine amidase NP_273710.1 696816 R 122586 CDS NP_273711.1 15676567 902780 697472..698467 1 NC_003112.2 identified by similarity to EGAD:46980; match to protein family HMM PF02618; match to protein family HMM TIGR00247; hypothetical protein 698467 902780 NMB0669 Neisseria meningitidis MC58 hypothetical protein NP_273711.1 697472 D 122586 CDS NP_273712.1 15676568 902781 698527..699147 1 NC_003112.2 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 699147 tmk 902781 tmk Neisseria meningitidis MC58 thymidylate kinase NP_273712.1 698527 D 122586 CDS NP_273713.1 15676569 902782 699369..700649 1 NC_003112.2 identified by similarity to GP:1799887; match to protein family HMM PF00390; match to protein family HMM PF03949; malate oxidoreductase (NAD) 700649 sfcA 902782 sfcA Neisseria meningitidis MC58 malate oxidoreductase (NAD) NP_273713.1 699369 D 122586 CDS NP_273714.1 15676570 902783 701196..702230 1 NC_003112.2 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 702230 lpxK 902783 lpxK Neisseria meningitidis MC58 tetraacyldisaccharide 4'-kinase NP_273714.1 701196 D 122586 CDS NP_273715.1 15676571 902784 702430..703017 1 NC_003112.2 hypothetical protein 703017 902784 NMB0673 Neisseria meningitidis MC58 hypothetical protein NP_273715.1 702430 D 122586 CDS NP_273716.1 15676572 902785 703086..703268 1 NC_003112.2 identified by similarity to EGAD:90683; match to protein family HMM PF03966; hypothetical protein 703268 902785 NMB0674 Neisseria meningitidis MC58 hypothetical protein NP_273716.1 703086 D 122586 CDS NP_273717.1 15676573 902786 703265..704026 1 NC_003112.2 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 704026 kdsB 902786 kdsB Neisseria meningitidis MC58 3-deoxy-manno-octulosonate cytidylyltransferase NP_273717.1 703265 D 122586 CDS NP_273718.1 15676574 902787 704049..704450 1 NC_003112.2 hypothetical protein 704450 902787 NMB0676 Neisseria meningitidis MC58 hypothetical protein NP_273718.1 704049 D 122586 CDS NP_273720.1 15676576 902790 705342..706127 1 NC_003112.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 706127 trpA 902790 trpA Neisseria meningitidis MC58 tryptophan synthase subunit alpha NP_273720.1 705342 D 122586 CDS NP_273721.1 15676577 902791 706165..707037 1 NC_003112.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 707037 accD 902791 accD Neisseria meningitidis MC58 acetyl-CoA carboxylase subunit beta NP_273721.1 706165 D 122586 CDS NP_273722.1 15676578 902792 complement(707097..707708) 1 NC_003112.2 identified by similarity to EGAD:20133; hypothetical protein 707708 cnp1 902792 cnp1 Neisseria meningitidis MC58 hypothetical protein NP_273722.1 707097 R 122586 CDS NP_273723.1 15676579 902793 707817..708041 1 NC_003112.2 identified by similarity to EGAD:45778; match to protein family HMM PF01206; hypothetical protein 708041 902793 NMB0681 Neisseria meningitidis MC58 hypothetical protein NP_273723.1 707817 D 122586 CDS NP_273724.1 15676580 902794 708404..709438 1 NC_003112.2 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 709438 pyrC 902794 pyrC Neisseria meningitidis MC58 dihydroorotase NP_273724.1 708404 D 122586 CDS NP_273725.1 15676581 902795 complement(709806..710231) 1 NC_003112.2 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 710231 nusB 902795 nusB Neisseria meningitidis MC58 transcription antitermination protein NusB NP_273725.1 709806 R 122586 CDS NP_273726.1 15676582 902796 complement(710309..710785) 1 NC_003112.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 710785 ribH 902796 ribH Neisseria meningitidis MC58 6,7-dimethyl-8-ribityllumazine synthase NP_273726.1 710309 R 122586 CDS NP_273727.1 15676583 902797 complement(710833..711156) 1 NC_003112.2 hypothetical protein 711156 902797 NMB0685 Neisseria meningitidis MC58 hypothetical protein NP_273727.1 710833 R 122586 CDS NP_273728.1 15676584 902798 711323..712042 1 NC_003112.2 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 712042 rnc 902798 rnc Neisseria meningitidis MC58 ribonuclease III NP_273728.1 711323 D 122586 CDS NP_273729.1 15676585 902799 712039..713013 1 NC_003112.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 713013 era 902799 era Neisseria meningitidis MC58 GTP-binding protein Era NP_273729.1 712039 D 122586 CDS NP_273730.1 15676586 902800 complement(714856..715482) 1 NC_003112.2 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 715482 trpF 902800 trpF Neisseria meningitidis MC58 N-(5'-phosphoribosyl)anthranilate isomerase NP_273730.1 714856 R 122586 CDS NP_273731.1 15676587 902801 complement(715541..716032) 1 NC_003112.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 716032 greB 902801 greB Neisseria meningitidis MC58 transcription elongation factor GreB NP_273731.1 715541 R 122586 CDS NP_273732.1 15676588 902802 complement(716132..717676) 1 NC_003112.2 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 717676 purF 902802 purF Neisseria meningitidis MC58 amidophosphoribosyltransferase NP_273732.1 716132 R 122586 CDS NP_273733.1 15676589 902803 complement(717989..718486) 1 NC_003112.2 identified by similarity to EGAD:28218; match to protein family HMM PF02674; colicin V production protein 718486 902803 NMB0691 Neisseria meningitidis MC58 colicin V production protein NP_273733.1 717989 R 122586 CDS NP_273734.1 15676590 902804 complement(718479..719477) 1 NC_003112.2 identified by similarity to EGAD:40704; match to protein family HMM PF05036; match to protein family HMM TIGR02223; tpc protein 719477 tpc 902804 tpc Neisseria meningitidis MC58 tpc protein NP_273734.1 718479 R 122586 CDS NP_273735.1 15676591 902805 complement(719490..720764) 1 NC_003112.2 identified by similarity to EGAD:40703; match to protein family HMM TIGR01499; bifunctional folylpolyglutamate synthase/dihydrofolate synthase 720764 folC 902805 folC Neisseria meningitidis MC58 bifunctional folylpolyglutamate synthase/dihydrofolate synthase NP_273735.1 719490 R 122586 CDS NP_273736.1 15676592 902806 complement(720795..721241) 1 NC_003112.2 identified by similarity to EGAD:40702; folI protein 721241 folI 902806 folI Neisseria meningitidis MC58 folI protein NP_273736.1 720795 R 122586 CDS NP_273737.1 15676593 902807 complement(721246..721605) 1 NC_003112.2 hypothetical protein 721605 902807 NMB0695 Neisseria meningitidis MC58 hypothetical protein NP_273737.1 721246 R 122586 CDS NP_273738.1 15676594 902808 complement(721678..722406) 1 NC_003112.2 identified by similarity to EGAD:12339; match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 722406 902808 NMB0696 Neisseria meningitidis MC58 amino acid ABC transporter ATP-binding protein NP_273738.1 721678 R 122586 CDS NP_273739.1 15676595 902809 complement(722579..723358) 1 NC_003112.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 723358 ksgA 902809 ksgA Neisseria meningitidis MC58 dimethyladenosine transferase NP_273739.1 722579 R 122586 CDS NP_273740.1 15676596 902810 723555..724244 1 NC_003112.2 hypothetical protein 724244 902810 NMB0698 Neisseria meningitidis MC58 hypothetical protein NP_273740.1 723555 D 122586 CDS NP_273741.1 15676597 902811 724327..725529 1 NC_003112.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 725529 trpB 902811 trpB Neisseria meningitidis MC58 tryptophan synthase subunit beta NP_273741.1 724327 D 122586 CDS NP_273742.1 15676598 902812 complement(725708..731155) 1 NC_003112.2 identified by similarity to GP:732874; match to protein family HMM PF02395; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; IgA-specific serine endopeptidase 731155 iga 902812 iga Neisseria meningitidis MC58 IgA-specific serine endopeptidase NP_273742.1 725708 R 122586 CDS NP_273744.1 15676600 902814 732566..734641 1 NC_003112.2 identified by similarity to EGAD:32733; match to protein family HMM PF00753; match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; competence protein 734641 comA 902814 comA Neisseria meningitidis MC58 competence protein NP_273744.1 732566 D 122586 CDS NP_273745.1 15676601 902815 complement(734869..735672) 1 NC_003112.2 identified by similarity to EGAD:40678; match to protein family HMM PF03696; competence lipoprotein 735672 comL 902815 comL Neisseria meningitidis MC58 competence lipoprotein NP_273745.1 734869 R 122586 CDS NP_273746.1 15676602 902816 735671..736795 1 NC_003112.2 identified by similarity to EGAD:5430; match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 736795 rluD 902816 rluD Neisseria meningitidis MC58 ribosomal large subunit pseudouridine synthase D NP_273746.1 735671 D 122586 CDS NP_273747.1 15676603 902817 complement(736948..737895) 1 NC_003112.2 identified by similarity to EGAD:109243; match to protein family HMM PF01758; transporter 737895 902817 NMB0705 Neisseria meningitidis MC58 transporter NP_273747.1 736948 R 122586 CDS NP_273748.1 15676604 902818 738455..739234 1 NC_003112.2 identified by similarity to EGAD:9801; match to protein family HMM PF02578; match to protein family HMM TIGR00726; hypothetical protein 739234 902818 NMB0706 Neisseria meningitidis MC58 hypothetical protein NP_273748.1 738455 D 122586 CDS NP_273749.1 15676605 902819 739286..739765 1 NC_003112.2 identified by similarity to EGAD:24661; match to protein family HMM PF04390; rare lipoprotein B 739765 902819 NMB0707 Neisseria meningitidis MC58 rare lipoprotein B NP_273749.1 739286 D 122586 CDS NP_273750.1 15676606 902820 739767..740765 1 NC_003112.2 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 740765 holA 902820 holA Neisseria meningitidis MC58 DNA polymerase III subunit delta NP_273750.1 739767 D 122586 CDS NP_273751.1 15676607 902821 740886..741305 1 NC_003112.2 hypothetical protein 741305 902821 NMB0709 Neisseria meningitidis MC58 hypothetical protein NP_273751.1 740886 D 122586 CDS NP_273752.1 15676608 902822 741330..741896 1 NC_003112.2 hypothetical protein 741896 902822 NMB0710 Neisseria meningitidis MC58 hypothetical protein NP_273752.1 741330 D 122586 CDS NP_273753.1 15676609 902823 complement(741980..742864) 1 NC_003112.2 identified by similarity to EGAD:15764; match to protein family HMM PF03755; match to protein family HMM TIGR00255; hypothetical protein 742864 902823 NMB0711 Neisseria meningitidis MC58 hypothetical protein NP_273753.1 741980 R 122586 CDS NP_273754.1 15676610 902824 complement(743348..744220) 1 NC_003112.2 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 744220 rpoH 902824 rpoH Neisseria meningitidis MC58 RNA polymerase factor sigma-32 NP_273754.1 743348 R 122586 CDS NP_273755.1 15676611 902825 complement(744476..746050) 1 NC_003112.2 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 746050 lnt 902825 lnt Neisseria meningitidis MC58 apolipoprotein N-acyltransferase NP_273755.1 744476 R 122586 CDS NP_273757.1 15676613 902827 747005..747325 1 NC_003112.2 hypothetical protein 747325 902827 NMB0715 Neisseria meningitidis MC58 hypothetical protein NP_273757.1 747005 D 122586 CDS NP_273758.1 15676614 902828 747478..747768 1 NC_003112.2 hypothetical protein 747768 902828 NMB0716 Neisseria meningitidis MC58 hypothetical protein NP_273758.1 747478 D 122586 CDS NP_273759.1 15676615 902829 complement(747831..748247) 1 NC_003112.2 identified by similarity to EGAD:40915; match to protein family HMM PF00034; cytochrome 748247 902829 NMB0717 Neisseria meningitidis MC58 cytochrome NP_273759.1 747831 R 122586 CDS NP_273760.1 15676616 902830 complement(748528..749610) 1 NC_003112.2 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 749610 hemH 902830 hemH Neisseria meningitidis MC58 ferrochelatase NP_273760.1 748528 R 122586 CDS NP_273761.1 15676617 902831 complement(749620..750735) 1 NC_003112.2 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 750735 tgt 902831 tgt Neisseria meningitidis MC58 queuine tRNA-ribosyltransferase NP_273761.1 749620 R 122586 CDS NP_273762.1 15676618 902833 751043..752956 1 NC_003112.2 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 752956 thrS 902833 thrS Neisseria meningitidis MC58 threonyl-tRNA synthetase NP_273762.1 751043 D 122586 CDS NP_273763.1 15676619 902834 753028..753495 1 NC_003112.2 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 753495 infC 902834 infC Neisseria meningitidis MC58 translation initiation factor IF-3 NP_273763.1 753028 D 122586 CDS NP_273764.1 15676620 902835 753642..753839 1 NC_003112.2 identified by similarity to GP:3095163; match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 753839 rpmI 902835 rpmI Neisseria meningitidis MC58 50S ribosomal protein L35 NP_273764.1 753642 D 122586 CDS NP_273765.1 15676621 902836 753852..754211 1 NC_003112.2 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 754211 rplT 902836 rplT Neisseria meningitidis MC58 50S ribosomal protein L20 NP_273765.1 753852 D 122586 CDS NP_273766.1 15676622 902837 754557..755549 1 NC_003112.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 755549 pheS 902837 pheS Neisseria meningitidis MC58 phenylalanyl-tRNA synthetase subunit alpha NP_273766.1 754557 D 122586 CDS NP_273767.1 15676623 902838 755732..756790 1 NC_003112.2 identified by similarity to EGAD:15667; match to protein family HMM PF00145; match to protein family HMM TIGR00675; modification methylase HgaI-1 756790 902838 NMB0725 Neisseria meningitidis MC58 modification methylase HgaI-1 NP_273767.1 755732 D 122586 CDS NP_273768.1 15676624 902839 756793..758262 1 NC_003112.2 identified by similarity to EGAD:14414; type II restriction enzyme HgaI 758262 902839 NMB0726 Neisseria meningitidis MC58 type II restriction enzyme HgaI NP_273768.1 756793 D 122586 CDS NP_273769.1 15676625 902840 758259..758909 1 NC_003112.2 identified by similarity to EGAD:89170; match to protein family HMM PF01555; N-6 adenine-specific DNA methylase 758909 902840 NMB0727 Neisseria meningitidis MC58 N-6 adenine-specific DNA methylase NP_273769.1 758259 D 122586 CDS NP_273770.1 15676626 902841 758934..761297 1 NC_003112.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 761297 pheT 902841 pheT Neisseria meningitidis MC58 phenylalanyl-tRNA synthetase subunit beta NP_273770.1 758934 D 122586 CDS NP_273771.1 15676627 902842 761371..761673 1 NC_003112.2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 761673 ihfA 902842 ihfA Neisseria meningitidis MC58 integration host factor subunit alpha NP_273771.1 761371 D 122586 CDS NP_273772.1 15676628 902843 762295..762780 1 NC_003112.2 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 762780 fxsA 902843 fxsA Neisseria meningitidis MC58 FxsA protein NP_273772.1 762295 D 122586 CDS NP_273773.1 15676629 902844 763040..763267 1 NC_003112.2 hypothetical protein 763267 902844 NMB0731 Neisseria meningitidis MC58 hypothetical protein NP_273773.1 763040 D 122586 CDS NP_273774.1 15676630 902845 763597..764898 1 NC_003112.2 identified by similarity to EGAD:28548; match to protein family HMM PF00202; match to protein family HMM TIGR00508; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 764898 bioA 902845 bioA Neisseria meningitidis MC58 adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_273774.1 763597 D 122586 CDS NP_273775.1 15676631 902846 764895..765542 1 NC_003112.2 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 765542 bioD 902846 bioD Neisseria meningitidis MC58 dithiobiotin synthetase NP_273775.1 764895 D 122586 CDS NP_273776.1 15676632 902847 765557..766033 1 NC_003112.2 hypothetical protein 766033 902847 NMB0734 Neisseria meningitidis MC58 hypothetical protein NP_273776.1 765557 D 122586 CDS NP_273777.1 15676633 902848 766063..766953 1 NC_003112.2 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 766953 ubiA 902848 ubiA Neisseria meningitidis MC58 4-hydroxybenzoate octaprenyltransferase NP_273777.1 766063 D 122586 CDS NP_273778.1 15676634 902849 767138..767587 1 NC_003112.2 identified by similarity to EGAD:15747; match to protein family HMM PF00359; match to protein family HMM TIGR01419; PTS system, nitrogen regulatory IIA protein 767587 ptsN 902849 ptsN Neisseria meningitidis MC58 PTS system, nitrogen regulatory IIA protein NP_273778.1 767138 D 122586 CDS NP_273779.1 15676635 902850 767589..768551 1 NC_003112.2 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 768551 902850 NMB0737 Neisseria meningitidis MC58 HPr kinase/phosphorylase NP_273779.1 767589 D 122586 CDS NP_273780.1 15676636 902851 768532..769386 1 NC_003112.2 identified by similarity to EGAD:28161; match to protein family HMM PF03668; hypothetical protein 769386 902851 NMB0738 Neisseria meningitidis MC58 hypothetical protein NP_273780.1 768532 D 122586 CDS NP_273781.1 15676637 902852 769467..770984 1 NC_003112.2 identified by similarity to EGAD:108433; match to protein family HMM PF01926; match to protein family HMM PF04079; match to protein family HMM TIGR00650; hypothetical protein 770984 902852 NMB0739 Neisseria meningitidis MC58 hypothetical protein NP_273781.1 769467 D 122586 CDS NP_273782.1 15676638 902853 771293..772966 1 NC_003112.2 identified by similarity to GP:1788969; match to protein family HMM TIGR00634; DNA repair protein RecN 772966 recN 902853 recN Neisseria meningitidis MC58 DNA repair protein RecN NP_273782.1 771293 D 122586 CDS NP_273783.1 15676639 902856 complement(773983..775422) 1 NC_003112.2 identified by similarity to EGAD:90903; hypothetical protein 775422 902856 NMB0741 Neisseria meningitidis MC58 hypothetical protein NP_273783.1 773983 R 122586 CDS NP_273784.1 15676640 902857 775722..776081 1 NC_003112.2 identified by similarity to EGAD:19920; match to protein family HMM PF06155; hypothetical protein 776081 902857 NMB0742 Neisseria meningitidis MC58 hypothetical protein NP_273784.1 775722 D 122586 CDS NP_273785.1 15676641 902858 776135..776872 1 NC_003112.2 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 776872 ubiE 902858 ubiE Neisseria meningitidis MC58 ubiquinone/menaquinone biosynthesis methyltransferase NP_273785.1 776135 D 122586 CDS NP_273786.1 15676642 902859 777092..777571 1 NC_003112.2 hypothetical protein 777571 902859 NMB0744 Neisseria meningitidis MC58 hypothetical protein NP_273786.1 777092 D 122586 CDS NP_273787.1 15676643 902860 complement(777697..778191) 1 NC_003112.2 identified by similarity to EGAD:27899; match to protein family HMM PF01288; match to protein family HMM TIGR01498; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 778191 folK 902860 folK Neisseria meningitidis MC58 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_273787.1 777697 R 122586 CDS NP_273788.1 15676644 902861 complement(778201..778575) 1 NC_003112.2 identified by similarity to EGAD:36863; match to protein family HMM PF04247; hypothetical protein 778575 902861 NMB0746 Neisseria meningitidis MC58 hypothetical protein NP_273788.1 778201 R 122586 CDS NP_273789.1 15676645 902862 complement(778629..779195) 1 NC_003112.2 identified by similarity to EGAD:108409; match to protein family HMM PF06962; hypothetical protein 779195 902862 NMB0747 Neisseria meningitidis MC58 hypothetical protein NP_273789.1 778629 R 122586 CDS NP_273790.1 15676646 902863 complement(779280..779573) 1 NC_003112.2 identified by similarity to GP:146861; match to protein family HMM PF01423; match to protein family HMM TIGR02383; host factor-I 779573 hfq 902863 hfq Neisseria meningitidis MC58 host factor-I NP_273790.1 779280 R 122586 CDS NP_273791.1 15676647 902864 complement(779702..780640) 1 NC_003112.2 identified by similarity to EGAD:8088; match to protein family HMM PF00768; penicillin-binding protein 4 780640 902864 NMB0749 Neisseria meningitidis MC58 penicillin-binding protein 4 NP_273791.1 779702 R 122586 CDS NP_273792.1 15676648 902865 780961..781401 1 NC_003112.2 identified by similarity to EGAD:48892; match to protein family HMM PF00578; bacterioferritin comigratory protein 781401 bcp 902865 bcp Neisseria meningitidis MC58 bacterioferritin comigratory protein NP_273792.1 780961 D 122586 CDS NP_273793.1 15676649 902866 781453..782328 1 NC_003112.2 identified by similarity to EGAD:24225; match to protein family HMM PF00589; match to protein family HMM PF02899; match to protein family HMM TIGR02225; integrase/recombinase XerD 782328 xerD 902866 xerD Neisseria meningitidis MC58 integrase/recombinase XerD NP_273793.1 781453 D 122586 CDS NP_273794.1 15676650 902867 782500..782700 1 NC_003112.2 identified by similarity to GP:4378826; match to protein family HMM PF04324; bacterioferritin-associated ferredoxin 782700 902867 NMB0752 Neisseria meningitidis MC58 bacterioferritin-associated ferredoxin NP_273794.1 782500 D 122586 CDS NP_273795.1 15676651 902868 782866..783099 1 NC_003112.2 identified by similarity to EGAD:46419; hypothetical protein 783099 902868 NMB0753 Neisseria meningitidis MC58 hypothetical protein NP_273795.1 782866 D 122586 CDS NP_273796.1 15676652 902869 783104..783214 1 NC_003112.2 hypothetical protein 783214 902869 NMB0754 Neisseria meningitidis MC58 hypothetical protein NP_273796.1 783104 D 122586 CDS NP_273797.1 15676653 902870 783232..783375 1 NC_003112.2 hypothetical protein 783375 902870 NMB0755 Neisseria meningitidis MC58 hypothetical protein NP_273797.1 783232 D 122586 CDS NP_273798.1 15676654 902871 complement(783516..784436) 1 NC_003112.2 identified by similarity to GP:2662408; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214; dTDP-L-rhamnose synthase 784436 902871 NMB0756 Neisseria meningitidis MC58 dTDP-L-rhamnose synthase NP_273798.1 783516 R 122586 CDS NP_273799.1 15676655 902872 784636..785499 1 NC_003112.2 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 785499 hemH 902872 hemH Neisseria meningitidis MC58 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_273799.1 784636 D 122586 CDS NP_273800.1 15676656 902873 785733..787856 1 NC_003112.2 identified by similarity to EGAD:12417; match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase 787856 pnp 902873 pnp Neisseria meningitidis MC58 polynucleotide phosphorylase NP_273800.1 785733 D 122586 CDS NP_273801.1 15676657 902874 complement(787929..788657) 1 NC_003112.2 identified by similarity to EGAD:89407; hypothetical protein 788657 902874 NMB0759 Neisseria meningitidis MC58 hypothetical protein NP_273801.1 787929 R 122586 CDS NP_273802.1 15676658 902875 789044..789895 1 NC_003112.2 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 789895 dapF 902875 dapF Neisseria meningitidis MC58 diaminopimelate epimerase NP_273802.1 789044 D 122586 CDS NP_273803.1 15676659 902876 789978..790205 1 NC_003112.2 hypothetical protein 790205 902876 NMB0761 Neisseria meningitidis MC58 hypothetical protein NP_273803.1 789978 D 122586 CDS NP_273805.1 15676661 902878 790691..791623 1 NC_003112.2 identified by similarity to EGAD:160962; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase 791623 cysK 902878 cysK Neisseria meningitidis MC58 cysteine synthase NP_273805.1 790691 D 122586 CDS NP_273806.1 15676662 902879 792086..792991 1 NC_003112.2 identified by similarity to GP:3413203; match to protein family HMM PF00892; hypothetical protein 792991 902879 NMB0764 Neisseria meningitidis MC58 hypothetical protein NP_273806.1 792086 D 122586 CDS NP_273807.1 15676663 902880 complement(793147..794166) 1 NC_003112.2 identified by similarity to EGAD:13376; match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I 794166 lepB 902880 lepB Neisseria meningitidis MC58 signal peptidase I NP_273807.1 793147 R 122586 CDS NP_273808.1 15676664 902881 complement(794309..796102) 1 NC_003112.2 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 796102 lepA 902881 lepA Neisseria meningitidis MC58 GTP-binding protein LepA NP_273808.1 794309 R 122586 CDS NP_273809.1 15676665 902882 complement(796246..796947) 1 NC_003112.2 identified by similarity to EGAD:109995; match to protein family HMM PF01048; match to protein family HMM TIGR01704; 5'-methylthioadenosine nucleosidase 796947 pfs 902882 pfs Neisseria meningitidis MC58 5'-methylthioadenosine nucleosidase NP_273809.1 796246 R 122586 CDS NP_273810.1 15676666 902883 797133..798245 1 NC_003112.2 identified by similarity to EGAD:14316; match to protein family HMM PF00437; match to protein family HMM TIGR01420; twitching motility protein PilT 798245 pilT-2 902883 pilT-2 Neisseria meningitidis MC58 twitching motility protein PilT NP_273810.1 797133 D 122586 CDS NP_273811.1 15676667 902884 798279..799256 1 NC_003112.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 799256 902884 NMB0769 Neisseria meningitidis MC58 DNA polymerase III subunit delta' NP_273811.1 798279 D 122586 CDS NP_273812.1 15676668 902885 799260..799610 1 NC_003112.2 identified by similarity to EGAD:38751; match to protein family HMM PF07238; type IV pilus assembly protein PilZ 799610 902885 NMB0770 Neisseria meningitidis MC58 type IV pilus assembly protein PilZ NP_273812.1 799260 D 122586 CDS NP_273813.1 15676669 902886 799615..800394 1 NC_003112.2 identified by similarity to EGAD:6599; match to protein family HMM PF01026; match to protein family HMM TIGR00010; hypothetical protein 800394 902886 NMB0771 Neisseria meningitidis MC58 hypothetical protein NP_273813.1 799615 D 122586 CDS NP_273814.1 15676670 902887 800420..800635 1 NC_003112.2 identified by similarity to EGAD:91807; match to protein family HMM PF03891; hypothetical protein 800635 902887 NMB0772 Neisseria meningitidis MC58 hypothetical protein NP_273814.1 800420 D 122586 CDS NP_273815.1 15676671 902888 800736..801047 1 NC_003112.2 identified by similarity to EGAD:50035; match to protein family HMM PF00462; match to protein family HMM TIGR00365; hypothetical protein 801047 902888 NMB0773 Neisseria meningitidis MC58 hypothetical protein NP_273815.1 800736 D 122586 CDS NP_273816.1 15676672 902889 801153..801779 1 NC_003112.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 801779 upp 902889 upp Neisseria meningitidis MC58 uracil phosphoribosyltransferase NP_273816.1 801153 D 122586 CDS NP_273817.1 15676673 902890 801802..802122 1 NC_003112.2 hypothetical protein 802122 902890 NMB0775 Neisseria meningitidis MC58 hypothetical protein NP_273817.1 801802 D 122586 CDS NP_273818.1 15676674 902891 802373..802792 1 NC_003112.2 identified by similarity to GP:2580593; hypothetical protein 802792 902891 NMB0776 Neisseria meningitidis MC58 hypothetical protein NP_273818.1 802373 D 122586 CDS NP_273819.1 15676675 902892 802834..803574 1 NC_003112.2 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 803574 hemD 902892 hemD Neisseria meningitidis MC58 uroporphyrinogen-III synthase NP_273819.1 802834 D 122586 CDS NP_273820.1 15676676 902893 803649..804923 1 NC_003112.2 identified by similarity to EGAD:22018; match to protein family HMM PF04375; uroporphyrin-III C-methyltransferase HemX 804923 902893 NMB0778 Neisseria meningitidis MC58 uroporphyrin-III C-methyltransferase HemX NP_273820.1 803649 D 122586 CDS NP_273821.1 15676677 902894 804920..806143 1 NC_003112.2 hypothetical protein 806143 902894 NMB0779 Neisseria meningitidis MC58 hypothetical protein NP_273821.1 804920 D 122586 CDS NP_273822.1 15676678 902895 806176..806616 1 NC_003112.2 hypothetical protein 806616 902895 NMB0780 Neisseria meningitidis MC58 hypothetical protein NP_273822.1 806176 D 122586 CDS NP_273823.1 15676679 902896 806770..807834 1 NC_003112.2 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 807834 hemE 902896 hemE Neisseria meningitidis MC58 uroporphyrinogen decarboxylase NP_273823.1 806770 D 122586 CDS NP_273824.1 15676680 902897 808020..809399 1 NC_003112.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 809399 radA 902897 radA Neisseria meningitidis MC58 DNA repair protein RadA NP_273824.1 808020 D 122586 CDS NP_273825.1 15676681 902898 complement(809675..810154) 1 NC_003112.2 identified by similarity to EGAD:157492; match to protein family HMM PF03625; hypothetical protein 810154 902898 NMB0783 Neisseria meningitidis MC58 hypothetical protein NP_273825.1 809675 R 122586 CDS NP_273826.1 15676682 902899 complement(810396..810755) 1 NC_003112.2 identified by similarity to EGAD:6573; match to protein family HMM PF00581; phage shock protein E 810755 902899 NMB0784 Neisseria meningitidis MC58 phage shock protein E NP_273826.1 810396 R 122586 CDS NP_273827.1 15676683 902900 complement(810794..814408) 1 NC_003112.2 identified by similarity to EGAD:28326; match to protein family HMM PF00580; match to protein family HMM TIGR00609; exodeoxyribonuclease V 135 KD polypeptide 814408 recB 902900 recB Neisseria meningitidis MC58 exodeoxyribonuclease V 135 KD polypeptide NP_273827.1 810794 R 122586 CDS NP_273828.1 15676684 902901 complement(814488..815396) 1 NC_003112.2 identified by similarity to EGAD:91404; match to protein family HMM PF04261; match to protein family HMM TIGR01413; hypothetical protein 815396 902901 NMB0786 Neisseria meningitidis MC58 hypothetical protein NP_273828.1 814488 R 122586 CDS NP_273829.1 15676685 902902 815681..816508 1 NC_003112.2 identified by similarity to EGAD:30720; match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 816508 902902 NMB0787 Neisseria meningitidis MC58 amino acid ABC transporter substrate-binding protein NP_273829.1 815681 D 122586 CDS NP_273830.1 15676686 902903 816552..817214 1 NC_003112.2 identified by similarity to EGAD:90043; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 817214 902903 NMB0788 Neisseria meningitidis MC58 amino acid ABC transporter permease NP_273830.1 816552 D 122586 CDS NP_273831.1 15676687 902904 817224..817979 1 NC_003112.2 identified by similarity to GP:666983; match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 817979 902904 NMB0789 Neisseria meningitidis MC58 amino acid ABC transporter ATP-binding protein NP_273831.1 817224 D 122586 CDS NP_273832.1 15676688 902905 complement(817999..819381) 1 NC_003112.2 identified by similarity to EGAD:13620; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphoglucomutase 819381 pgm 902905 pgm Neisseria meningitidis MC58 phosphoglucomutase NP_273832.1 817999 R 122586 CDS NP_273833.1 15676689 902906 complement(819548..820057) 1 NC_003112.2 identified by similarity to EGAD:28733; match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase 820057 902906 NMB0791 Neisseria meningitidis MC58 peptidyl-prolyl cis-trans isomerase NP_273833.1 819548 R 122586 CDS NP_273834.1 15676690 902907 complement(820176..821591) 1 NC_003112.2 identified by similarity to EGAD:29242; match to protein family HMM PF00939; match to protein family HMM TIGR00785; NadC family protein 821591 902907 NMB0792 Neisseria meningitidis MC58 NadC family protein NP_273834.1 820176 R 122586 CDS NP_273835.1 15676691 902908 complement(821588..821797) 1 NC_003112.2 hypothetical protein 821797 902908 NMB0793 Neisseria meningitidis MC58 hypothetical protein NP_273835.1 821588 R 122586 CDS NP_273836.1 15676692 902909 complement(821822..822184) 1 NC_003112.2 hypothetical protein 822184 902909 NMB0794 Neisseria meningitidis MC58 hypothetical protein NP_273836.1 821822 R 122586 CDS NP_273837.1 15676693 902910 complement(822448..823026) 1 NC_003112.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 823026 pth 902910 pth Neisseria meningitidis MC58 peptidyl-tRNA hydrolase NP_273837.1 822448 R 122586 CDS NP_273838.1 15676694 902911 complement(823079..823357) 1 NC_003112.2 identified by similarity to EGAD:35606; match to protein family HMM PF03658; hypothetical protein 823357 902911 NMB0796 Neisseria meningitidis MC58 hypothetical protein NP_273838.1 823079 R 122586 CDS NP_273839.1 15676695 902912 complement(823350..823787) 1 NC_003112.2 identified by similarity to EGAD:34195; match to protein family HMM PF03364; hypothetical protein 823787 902912 NMB0797 Neisseria meningitidis MC58 hypothetical protein NP_273839.1 823350 R 122586 CDS NP_273840.1 15676696 902913 complement(824003..825970) 1 NC_003112.2 identified by similarity to EGAD:13183; match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; cell division protein FtsH 825970 ftsH 902913 ftsH Neisseria meningitidis MC58 cell division protein FtsH NP_273840.1 824003 R 122586 CDS NP_273841.1 15676697 902914 complement(826034..826654) 1 NC_003112.2 identified by similarity to EGAD:22071; match to protein family HMM PF01728; cell division protein FtsJ 826654 ftsJ 902914 ftsJ Neisseria meningitidis MC58 cell division protein FtsJ NP_273841.1 826034 R 122586 CDS NP_273842.1 15676698 902915 826764..827048 1 NC_003112.2 identified by similarity to EGAD:133408; match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein 827048 902915 NMB0800 Neisseria meningitidis MC58 hypothetical protein NP_273842.1 826764 D 122586 CDS NP_273843.1 15676699 902916 827231..828232 1 NC_003112.2 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 828232 hemB 902916 hemB Neisseria meningitidis MC58 delta-aminolevulinic acid dehydratase NP_273843.1 827231 D 122586 CDS NP_273844.1 15676700 902917 complement(828295..829452) 1 NC_003112.2 identified by similarity to EGAD:109991; match to protein family HMM PF01053; cystathionine gamma-synthase 829452 metB 902917 metB Neisseria meningitidis MC58 cystathionine gamma-synthase NP_273844.1 828295 R 122586 CDS NP_273845.1 15676701 902918 829644..830417 1 NC_003112.2 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis; GTP cyclohydrolase 830417 902918 NMB0803 Neisseria meningitidis MC58 GTP cyclohydrolase NP_273845.1 829644 D 122586 CDS NP_273846.1 15676702 902919 830527..831192 1 NC_003112.2 identified by similarity to EGAD:28277; match to protein family HMM PF00881; NAD(P)H nitroreductase 831192 902919 NMB0804 Neisseria meningitidis MC58 NAD(P)H nitroreductase NP_273846.1 830527 D 122586 CDS NP_273847.1 15676703 902920 831333..832298 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 832298 902920 NMB0805 Neisseria meningitidis MC58 IS30 family transposase NP_273847.1 831333 D 122586 CDS NP_273848.1 15676704 902921 complement(832330..833088) 1 NC_003112.2 identified by similarity to EGAD:156128; match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; hypothetical protein 833088 902921 NMB0806 Neisseria meningitidis MC58 hypothetical protein NP_273848.1 832330 R 122586 CDS NP_273849.1 15676705 902922 complement(833113..834003) 1 NC_003112.2 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 834003 ppnK 902922 ppnK Neisseria meningitidis MC58 inorganic polyphosphate/ATP-NAD kinase NP_273849.1 833113 R 122586 CDS NP_273850.1 15676706 902923 complement(834023..834589) 1 NC_003112.2 hypothetical protein 834589 902923 NMB0808 Neisseria meningitidis MC58 hypothetical protein NP_273850.1 834023 R 122586 CDS NP_273851.1 15676707 902924 complement(834640..835437) 1 NC_003112.2 identified by similarity to EGAD:91119; hypothetical protein 835437 902924 NMB0809 Neisseria meningitidis MC58 hypothetical protein NP_273851.1 834640 R 122586 CDS NP_273852.1 15676708 902925 complement(835492..836142) 1 NC_003112.2 identified by similarity to EGAD:17310; match to protein family HMM PF00440; TetR family transcriptional regulator 836142 902925 NMB0810 Neisseria meningitidis MC58 TetR family transcriptional regulator NP_273852.1 835492 R 122586 CDS NP_273853.1 15676709 902926 complement(836154..837194) 1 NC_003112.2 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 837194 murB 902926 murB Neisseria meningitidis MC58 UDP-N-acetylenolpyruvoylglucosamine reductase NP_273853.1 836154 R 122586 CDS NP_273854.1 15676710 902927 complement(837238..838617) 1 NC_003112.2 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 838617 902927 NMB0812 Neisseria meningitidis MC58 multidrug efflux protein NP_273854.1 837238 R 122586 CDS NP_273856.1 15676712 902929 838952..840103 1 NC_003112.2 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase 840103 hisZ 902929 hisZ Neisseria meningitidis MC58 ATP phosphoribosyltransferase NP_273856.1 838952 D 122586 CDS NP_273857.1 15676713 902930 840201..841505 1 NC_003112.2 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 841505 purA 902930 purA Neisseria meningitidis MC58 adenylosuccinate synthetase NP_273857.1 840201 D 122586 CDS NP_273859.1 15676715 902932 841970..842353 1 NC_003112.2 hypothetical protein 842353 902932 NMB0817 Neisseria meningitidis MC58 hypothetical protein NP_273859.1 841970 D 122586 CDS NP_273860.1 15676716 902933 842367..842777 1 NC_003112.2 hypothetical protein 842777 902933 NMB0818 Neisseria meningitidis MC58 hypothetical protein NP_273860.1 842367 D 122586 CDS NP_273861.1 15676717 902934 842894..843286 1 NC_003112.2 hypothetical protein 843286 902934 NMB0819 Neisseria meningitidis MC58 hypothetical protein NP_273861.1 842894 D 122586 CDS NP_273862.1 15676718 902935 843494..843886 1 NC_003112.2 hypothetical protein 843886 902935 NMB0820 Neisseria meningitidis MC58 hypothetical protein NP_273862.1 843494 D 122586 CDS NP_273864.1 15676720 902937 complement(844861..845904) 1 NC_003112.2 metalloprotease; heat shock protein HtpX 845904 htpX 902937 htpX Neisseria meningitidis MC58 heat shock protein HtpX NP_273864.1 844861 R 122586 CDS NP_273865.1 15676721 902938 845916..846563 1 NC_003112.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 846563 adk 902938 adk Neisseria meningitidis MC58 adenylate kinase NP_273865.1 845916 D 122586 CDS NP_273866.1 15676722 902939 847089..847829 1 NC_003112.2 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 847829 pyrF 902939 pyrF Neisseria meningitidis MC58 orotidine 5'-phosphate decarboxylase NP_273866.1 847089 D 122586 CDS NP_273867.1 15676723 902940 847884..848855 1 NC_003112.2 identified by similarity to GP:1017464; match to protein family HMM PF00294; match to protein family HMM TIGR02198; ADP-heptose synthase 848855 902940 NMB0825 Neisseria meningitidis MC58 ADP-heptose synthase NP_273867.1 847884 D 122586 CDS NP_273868.1 15676724 902941 848892..850127 1 NC_003112.2 identified by similarity to EGAD:38043; match to protein family HMM PF00145; match to protein family HMM TIGR00675; C-5 cytosine-specific DNA methylase 850127 902941 NMB0826 Neisseria meningitidis MC58 C-5 cytosine-specific DNA methylase NP_273868.1 848892 D 122586 CDS NP_273870.1 15676725 902942 851289..852293 1 NC_003112.2 identified by similarity to EGAD:22136; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR02197; ADP-L-glycero-D-manno-heptose-6-epimerase 852293 rfaD 902942 rfaD Neisseria meningitidis MC58 ADP-L-glycero-D-manno-heptose-6-epimerase NP_273870.1 851289 D 122586 CDS NP_273871.1 15676726 902943 852367..853911 1 NC_003112.2 identified by similarity to GP:450688; match to protein family HMM PF02384; match to protein family HMM PF02506; match to protein family HMM TIGR00497; type I restriction enzyme EcoR124II M protein 853911 hsdM 902943 hsdM Neisseria meningitidis MC58 type I restriction enzyme EcoR124II M protein NP_273871.1 852367 D 122586 CDS NP_273872.1 15676727 902944 853908..854918 1 NC_003112.2 identified by similarity to GP:4324608; hypothetical protein 854918 902944 NMB0830 Neisseria meningitidis MC58 hypothetical protein NP_273872.1 853908 D 122586 CDS NP_273873.1 15676728 902946 856315..857457 1 NC_003112.2 identified by similarity to EGAD:6689; anticodon nuclease 857457 prrC 902946 prrC Neisseria meningitidis MC58 anticodon nuclease NP_273873.1 856315 D 122586 CDS NP_273874.1 15676729 902947 857454..857840 1 NC_003112.2 identified by similarity to EGAD:28865; type I restriction enzyme-like protein 857840 902947 NMB0833 Neisseria meningitidis MC58 type I restriction enzyme-like protein NP_273874.1 857454 D 122586 CDS NP_273875.1 15676730 902948 complement(857829..858794) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 858794 902948 NMB0834 Neisseria meningitidis MC58 IS30 family transposase NP_273875.1 857829 R 122586 CDS NP_273876.1 15676731 902949 858870..861635 1 NC_003112.2 identified by similarity to EGAD:89363; match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM TIGR00348; type I restriction enzyme EcoR124II R protein 861635 902949 NMB0835 Neisseria meningitidis MC58 type I restriction enzyme EcoR124II R protein NP_273876.1 858870 D 122586 CDS NP_273877.1 15676732 902950 complement(861674..863983) 1 NC_003112.2 identified by similarity to EGAD:17776; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; ATP-dependent Clp protease, ATP-binding subunit ClpA 863983 clpA 902950 clpA Neisseria meningitidis MC58 ATP-dependent Clp protease, ATP-binding subunit ClpA NP_273877.1 861674 R 122586 CDS NP_273878.1 15676733 902951 complement(863985..864287) 1 NC_003112.2 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 864287 clpS 902951 clpS Neisseria meningitidis MC58 ATP-dependent Clp protease adaptor protein ClpS NP_273878.1 863985 R 122586 CDS NP_273879.1 15676734 902952 864530..864733 1 NC_003112.2 identified by similarity to EGAD:97967; match to protein family HMM PF00313; cold-shock domain-contain protein 864733 902952 NMB0838 Neisseria meningitidis MC58 cold-shock domain-contain protein NP_273879.1 864530 D 122586 CDS NP_273880.1 15676735 902953 complement(865030..866361) 1 NC_003112.2 identified by similarity to EGAD:28167; match to protein family HMM PF01523; pmbA protein 866361 pmbA 902953 pmbA Neisseria meningitidis MC58 pmbA protein NP_273880.1 865030 R 122586 CDS NP_273881.1 15676736 902954 866484..867020 1 NC_003112.2 identified by similarity to EGAD:28166; match to protein family HMM PF04751; hypothetical protein 867020 902954 NMB0840 Neisseria meningitidis MC58 hypothetical protein NP_273881.1 866484 D 122586 CDS NP_273882.1 15676737 902955 867067..867783 1 NC_003112.2 hypothetical protein 867783 902955 NMB0841 Neisseria meningitidis MC58 hypothetical protein NP_273882.1 867067 D 122586 CDS NP_273883.1 15676738 902956 867852..869552 1 NC_003112.2 identified by similarity to GP:147550; match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 869552 recJ 902956 recJ Neisseria meningitidis MC58 single-stranded-DNA-specific exonuclease RecJ NP_273883.1 867852 D 122586 CDS NP_273884.1 15676739 902957 869849..871210 1 NC_003112.2 identified by similarity to GP:3650360; match to protein family HMM PF01743; match to protein family HMM TIGR01942; poly(A) polymerase 871210 pcnB 902957 pcnB Neisseria meningitidis MC58 poly(A) polymerase NP_273884.1 869849 D 122586 CDS NP_273885.1 15676740 902958 871383..871706 1 NC_003112.2 hypothetical protein 871706 902958 NMB0844 Neisseria meningitidis MC58 hypothetical protein NP_273885.1 871383 D 122586 CDS NP_273886.1 15676741 902959 complement(871817..872770) 1 NC_003112.2 identified by similarity to EGAD:91454; match to protein family HMM PF02562; PhoH-related protein 872770 902959 NMB0845 Neisseria meningitidis MC58 PhoH-related protein NP_273886.1 871817 R 122586 CDS NP_273889.1 15676744 902962 874407..875111 1 NC_003112.2 hypothetical protein 875111 902962 NMB0848 Neisseria meningitidis MC58 hypothetical protein NP_273889.1 874407 D 122586 CDS NP_273890.1 15676745 902963 complement(875175..875741) 1 NC_003112.2 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 875741 dcd 902963 dcd Neisseria meningitidis MC58 deoxycytidine triphosphate deaminase NP_273890.1 875175 R 122586 CDS NP_273891.1 15676746 902964 complement(875807..876223) 1 NC_003112.2 hypothetical protein 876223 902964 NMB0850 Neisseria meningitidis MC58 hypothetical protein NP_273891.1 875807 R 122586 CDS NP_273892.1 15676747 902965 complement(876285..877184) 1 NC_003112.2 Required for efficient pilin antigenic variation; recombination associated protein 877184 rdgC 902965 rdgC Neisseria meningitidis MC58 recombination associated protein NP_273892.1 876285 R 122586 CDS NP_273893.1 15676748 902966 complement(877215..878672) 1 NC_003112.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 878672 engA 902966 engA Neisseria meningitidis MC58 GTP-binding protein EngA NP_273893.1 877215 R 122586 CDS NP_273894.1 15676749 902967 complement(878822..879451) 1 NC_003112.2 identified by similarity to EGAD:90623; match to protein family HMM PF07719; hypothetical protein 879451 902967 NMB0853 Neisseria meningitidis MC58 hypothetical protein NP_273894.1 878822 R 122586 CDS NP_273895.1 15676750 902968 complement(879452..880747) 1 NC_003112.2 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 880747 hisS 902968 hisS Neisseria meningitidis MC58 histidyl-tRNA synthetase NP_273895.1 879452 R 122586 CDS NP_273896.1 15676751 902969 complement(880841..881497) 1 NC_003112.2 identified by similarity to GP:2909665; match to protein family HMM PF03412; bacteriocin resistance protein 881497 902969 NMB0855 Neisseria meningitidis MC58 bacteriocin resistance protein NP_273896.1 880841 R 122586 CDS NP_273897.1 15676752 902970 complement(881779..882246) 1 NC_003112.2 hypothetical protein 882246 902970 NMB0856 Neisseria meningitidis MC58 hypothetical protein NP_273897.1 881779 R 122586 CDS NP_273898.1 15676753 902971 complement(882303..882479) 1 NC_003112.2 hypothetical protein 882479 902971 NMB0857 Neisseria meningitidis MC58 hypothetical protein NP_273898.1 882303 R 122586 CDS NP_273899.1 15676754 902972 complement(882483..882683) 1 NC_003112.2 hypothetical protein 882683 902972 NMB0858 Neisseria meningitidis MC58 hypothetical protein NP_273899.1 882483 R 122586 CDS NP_273902.1 15676757 902975 complement(883468..884013) 1 NC_003112.2 hypothetical protein 884013 902975 NMB0861 Neisseria meningitidis MC58 hypothetical protein NP_273902.1 883468 R 122586 CDS NP_273903.1 15676758 902976 complement(884010..884129) 1 NC_003112.2 hypothetical protein 884129 902976 NMB0862 Neisseria meningitidis MC58 hypothetical protein NP_273903.1 884010 R 122586 CDS NP_273905.1 15676760 902978 complement(884714..885004) 1 NC_003112.2 hypothetical protein 885004 902978 NMB0864 Neisseria meningitidis MC58 hypothetical protein NP_273905.1 884714 R 122586 CDS NP_273906.1 15676761 902979 complement(885010..885483) 1 NC_003112.2 hypothetical protein 885483 902979 NMB0865 Neisseria meningitidis MC58 hypothetical protein NP_273906.1 885010 R 122586 CDS NP_273907.1 15676762 902980 complement(885526..886395) 1 NC_003112.2 hypothetical protein 886395 902980 NMB0866 Neisseria meningitidis MC58 hypothetical protein NP_273907.1 885526 R 122586 CDS NP_273908.1 15676763 902981 886559..887482 1 NC_003112.2 identified by similarity to EGAD:161394; match to protein family HMM PF00849; YabO/YceC/SfhB family protein 887482 902981 NMB0867 Neisseria meningitidis MC58 YabO/YceC/SfhB family protein NP_273908.1 886559 D 122586 CDS NP_273909.1 15676764 902982 complement(887560..888201) 1 NC_003112.2 identified by similarity to EGAD:162676; hypothetical protein 888201 902982 NMB0868 Neisseria meningitidis MC58 hypothetical protein NP_273909.1 887560 R 122586 CDS NP_273910.1 15676765 902983 complement(888256..889047) 1 NC_003112.2 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 889047 902983 NMB0869 Neisseria meningitidis MC58 spermidine synthase NP_273910.1 888256 R 122586 CDS NP_273911.1 15676766 902986 889540..890331 1 NC_003112.2 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 890331 panB 902986 panB Neisseria meningitidis MC58 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_273911.1 889540 D 122586 CDS NP_273912.1 15676767 902987 890454..891290 1 NC_003112.2 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 891290 panC 902987 panC Neisseria meningitidis MC58 pantoate--beta-alanine ligase NP_273912.1 890454 D 122586 CDS NP_273913.1 15676768 902988 891454..893298 1 NC_003112.2 identified by similarity to EGAD:30939; match to protein family HMM PF07719; hypothetical protein 893298 902988 NMB0872 Neisseria meningitidis MC58 hypothetical protein NP_273913.1 891454 D 122586 CDS NP_273914.1 15676769 902989 893438..894019 1 NC_003112.2 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 894019 lolB 902989 lolB Neisseria meningitidis MC58 outer membrane lipoprotein LolB NP_273914.1 893438 D 122586 CDS NP_273915.1 15676770 902990 894029..894874 1 NC_003112.2 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 894874 ipk 902990 ipk Neisseria meningitidis MC58 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_273915.1 894029 D 122586 CDS NP_273916.1 15676771 902994 895296..896279 1 NC_003112.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 896279 prsA 902994 prsA Neisseria meningitidis MC58 ribose-phosphate pyrophosphokinase NP_273916.1 895296 D 122586 CDS NP_273917.1 15676772 902995 896346..896918 1 NC_003112.2 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 896918 rplY 902995 rplY Neisseria meningitidis MC58 50S ribosomal protein L25 NP_273917.1 896346 D 122586 CDS NP_273918.1 15676773 902996 complement(897043..898212) 1 NC_003112.2 identified by similarity to EGAD:10529; match to protein family HMM PF00768; match to protein family HMM PF07943; penicillin-binding protein 898212 902996 NMB0877 Neisseria meningitidis MC58 penicillin-binding protein NP_273918.1 897043 R 122586 CDS NP_273919.1 15676774 902997 898360..899886 1 NC_003112.2 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 899886 ilvA 902997 ilvA Neisseria meningitidis MC58 threonine dehydratase NP_273919.1 898360 D 122586 CDS NP_273920.1 15676775 902998 complement(899943..901016) 1 NC_003112.2 identified by similarity to EGAD:20843; match to protein family HMM PF00005; match to protein family HMM TIGR00968; sulfate ABC transporter ATP-binding protein 901016 cysA 902998 cysA Neisseria meningitidis MC58 sulfate ABC transporter ATP-binding protein NP_273920.1 899943 R 122586 CDS NP_273921.1 15676776 902999 complement(901013..901873) 1 NC_003112.2 identified by similarity to EGAD:49750; match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02140; sulfate ABC transporter permease 901873 cysW 902999 cysW Neisseria meningitidis MC58 sulfate ABC transporter permease NP_273921.1 901013 R 122586 CDS NP_273922.1 15676777 903000 complement(902125..902961) 1 NC_003112.2 identified by similarity to EGAD:14734; match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02139; sulfate ABC transporter permease 902961 cysT 903000 cysT Neisseria meningitidis MC58 sulfate ABC transporter permease NP_273922.1 902125 R 122586 CDS NP_273923.1 15676778 903001 903252..903584 1 NC_003112.2 hypothetical protein 903584 903001 NMB0882 Neisseria meningitidis MC58 hypothetical protein NP_273923.1 903252 D 122586 CDS NP_273924.1 15676779 903002 903916..904425 1 NC_003112.2 identified by similarity to EGAD:28959; match to protein family HMM PF04140; hypothetical protein 904425 903002 NMB0883 Neisseria meningitidis MC58 hypothetical protein NP_273924.1 903916 D 122586 CDS NP_273925.1 15676780 903003 complement(904942..905529) 1 NC_003112.2 identified by similarity to EGAD:12983; match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase 905529 sodB 903003 sodB Neisseria meningitidis MC58 superoxide dismutase NP_273925.1 904942 R 122586 CDS NP_273926.1 15676781 903004 905693..907099 1 NC_003112.2 unwinds double stranded DNA; replicative DNA helicase 907099 dnaB 903004 dnaB Neisseria meningitidis MC58 replicative DNA helicase NP_273926.1 905693 D 122586 CDS NP_273927.1 15676782 903005 907408..908076 1 NC_003112.2 identified by similarity to SP:P13253; match to protein family HMM PF07963; match to protein family HMM TIGR02532; fimbrial protein FimT 908076 fimT 903005 fimT Neisseria meningitidis MC58 fimbrial protein FimT NP_273927.1 907408 D 122586 CDS NP_273928.1 15676783 903006 908094..908708 1 NC_003112.2 identified by similarity to EGAD:38517; match to protein family HMM TIGR02523; match to protein family HMM TIGR02532; type IV pilus assembly protein PilV 908708 903006 NMB0887 Neisseria meningitidis MC58 type IV pilus assembly protein PilV NP_273928.1 908094 D 122586 CDS NP_273929.1 15676784 903007 908705..909646 1 NC_003112.2 hypothetical protein 909646 903007 NMB0888 Neisseria meningitidis MC58 hypothetical protein NP_273929.1 908705 D 122586 CDS NP_273930.1 15676785 903008 909625..910218 1 NC_003112.2 hypothetical protein 910218 903008 NMB0889 Neisseria meningitidis MC58 hypothetical protein NP_273930.1 909625 D 122586 CDS NP_273931.1 15676786 903009 910208..910696 1 NC_003112.2 identified by similarity to SP:P35645; match to protein family HMM PF07963; match to protein family HMM TIGR02532; type IV pilin-like protein 910696 903009 NMB0890 Neisseria meningitidis MC58 type IV pilin-like protein NP_273931.1 910208 D 122586 CDS NP_273933.1 15676788 903011 complement(912411..912833) 1 NC_003112.2 identified by similarity to EGAD:91802; match to protein family HMM PF03591; AzlC-like protein 912833 903011 NMB0892 Neisseria meningitidis MC58 AzlC-like protein NP_273933.1 912411 R 122586 CDS NP_273934.1 15676789 903012 913033..913485 1 NC_003112.2 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 913485 dut 903012 dut Neisseria meningitidis MC58 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_273934.1 913033 D 122586 CDS NP_273935.1 15676790 903013 913563..914750 1 NC_003112.2 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate; succinyldiaminopimelate transaminase 914750 903013 NMB0894 Neisseria meningitidis MC58 succinyldiaminopimelate transaminase NP_273935.1 913563 D 122586 CDS NP_273936.1 15676791 903014 915013..915792 1 NC_003112.2 identified by similarity to EGAD:17611; match to protein family HMM PF03883; hypothetical protein 915792 903014 NMB0895 Neisseria meningitidis MC58 hypothetical protein NP_273936.1 915013 D 122586 CDS NP_273937.1 15676792 903018 917506..917886 1 NC_003112.2 hypothetical protein 917886 903018 NMB0897 Neisseria meningitidis MC58 hypothetical protein NP_273937.1 917506 D 122586 CDS NP_273940.1 15676795 903021 919659..920576 1 NC_003112.2 hypothetical protein 920576 903021 NMB0900 Neisseria meningitidis MC58 hypothetical protein NP_273940.1 919659 D 122586 CDS NP_273942.1 15676797 903023 complement(920980..921171) 1 NC_003112.2 hypothetical protein 921171 903023 NMB0902 Neisseria meningitidis MC58 hypothetical protein NP_273942.1 920980 R 122586 CDS NP_273943.1 15676798 903024 complement(921174..921467) 1 NC_003112.2 hypothetical protein 921467 903024 NMB0903 Neisseria meningitidis MC58 hypothetical protein NP_273943.1 921174 R 122586 CDS NP_273944.1 15676799 903025 complement(921464..921724) 1 NC_003112.2 hypothetical protein 921724 903025 NMB0904 Neisseria meningitidis MC58 hypothetical protein NP_273944.1 921464 R 122586 CDS NP_273945.1 15676800 903026 complement(921759..921974) 1 NC_003112.2 hypothetical protein 921974 903026 NMB0905 Neisseria meningitidis MC58 hypothetical protein NP_273945.1 921759 R 122586 CDS NP_273946.1 15676801 903027 complement(922044..922898) 1 NC_003112.2 hypothetical protein 922898 903027 NMB0906 Neisseria meningitidis MC58 hypothetical protein NP_273946.1 922044 R 122586 CDS NP_273947.1 15676802 903028 complement(922923..923282) 1 NC_003112.2 hypothetical protein 923282 903028 NMB0907 Neisseria meningitidis MC58 hypothetical protein NP_273947.1 922923 R 122586 CDS NP_273948.1 15676803 903029 complement(923350..923550) 1 NC_003112.2 hypothetical protein 923550 903029 NMB0908 Neisseria meningitidis MC58 hypothetical protein NP_273948.1 923350 R 122586 CDS NP_273949.1 15676804 903030 complement(923794..924318) 1 NC_003112.2 hypothetical protein 924318 903030 NMB0909 Neisseria meningitidis MC58 hypothetical protein NP_273949.1 923794 R 122586 CDS NP_273950.1 15676805 903031 complement(924322..925038) 1 NC_003112.2 identified by similarity to EGAD:140942; match to protein family HMM PF00717; transcriptional regulator 925038 903031 NMB0910 Neisseria meningitidis MC58 transcriptional regulator NP_273950.1 924322 R 122586 CDS NP_273951.1 15676806 903032 complement(925455..926420) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 926420 903032 NMB0911 Neisseria meningitidis MC58 IS30 family transposase NP_273951.1 925455 R 122586 CDS NP_273952.1 15676807 903033 926564..927190 1 NC_003112.2 hypothetical protein 927190 903033 NMB0912 Neisseria meningitidis MC58 hypothetical protein NP_273952.1 926564 D 122586 CDS NP_273953.1 15676808 903034 complement(927243..927590) 1 NC_003112.2 identified by similarity to GP:2688953; pemK protein 927590 pemK 903034 pemK Neisseria meningitidis MC58 pemK protein NP_273953.1 927243 R 122586 CDS NP_273954.1 15676809 903035 complement(927592..927828) 1 NC_003112.2 identified by similarity to EGAD:24580; match to protein family HMM PF04014; pemI protein 927828 pemI 903035 pemI Neisseria meningitidis MC58 pemI protein NP_273954.1 927592 R 122586 CDS NP_273955.1 15676810 903036 complement(928187..928678) 1 NC_003112.2 hypothetical protein 928678 903036 NMB0915 Neisseria meningitidis MC58 hypothetical protein NP_273955.1 928187 R 122586 CDS NP_273956.1 15676811 903037 complement(928697..928837) 1 NC_003112.2 hypothetical protein 928837 903037 NMB0916 Neisseria meningitidis MC58 hypothetical protein NP_273956.1 928697 R 122586 CDS NP_273957.1 15676812 903038 complement(929116..929484) 1 NC_003112.2 identified by similarity to EGAD:69439; match to protein family HMM PF05012; match to protein family HMM TIGR01550; death-on-curing protein 929484 903038 NMB0917 Neisseria meningitidis MC58 death-on-curing protein NP_273957.1 929116 R 122586 CDS NP_273958.1 15676813 903039 complement(929481..929612) 1 NC_003112.2 hypothetical protein 929612 903039 NMB0918 Neisseria meningitidis MC58 hypothetical protein NP_273958.1 929481 R 122586 CDS NP_273959.1 15676814 903040 complement(930008..930967) 1 NC_003112.2 identified by similarity to EGAD:5595; match to protein family HMM PF01609; IS1106 transposase 930967 903040 NMB0919 Neisseria meningitidis MC58 IS1106 transposase NP_273959.1 930008 R 122586 CDS NP_273960.1 15676815 903041 complement(932130..934355) 1 NC_003112.2 identified by similarity to EGAD:40125; match to protein family HMM PF03971; match to protein family HMM TIGR00178; isocitrate dehydrogenase, NADP-dependent, monomeric type 934355 icd 903041 icd Neisseria meningitidis MC58 isocitrate dehydrogenase, NADP-dependent, monomeric type NP_273960.1 932130 R 122586 CDS NP_273961.1 15676816 903042 complement(934360..934560) 1 NC_003112.2 hypothetical protein 934560 903042 NMB0921 Neisseria meningitidis MC58 hypothetical protein NP_273961.1 934360 R 122586 CDS NP_273962.1 15676817 903043 934788..935903 1 NC_003112.2 identified by similarity to EGAD:154767; match to protein family HMM PF07922; alpha-2,3-sialyltransferase 935903 903043 NMB0922 Neisseria meningitidis MC58 alpha-2,3-sialyltransferase NP_273962.1 934788 D 122586 CDS NP_273963.1 15676818 903044 complement(936068..936526) 1 NC_003112.2 identified by similarity to EGAD:138762; match to protein family HMM PF01322; cytochrome c 936526 903044 NMB0923 Neisseria meningitidis MC58 cytochrome c NP_273963.1 936068 R 122586 CDS NP_273964.1 15676819 903045 936645..937466 1 NC_003112.2 identified by similarity to EGAD:28429; match to protein family HMM PF00106; short chain dehydrogenase/reductase oxidoreductase 937466 903045 NMB0924 Neisseria meningitidis MC58 short chain dehydrogenase/reductase oxidoreductase NP_273964.1 936645 D 122586 CDS NP_273965.1 15676820 903046 complement(937517..937963) 1 NC_003112.2 identified by similarity to EGAD:21663; match to protein family HMM PF03061; acyl CoA thioester hydrolase 937963 903046 NMB0925 Neisseria meningitidis MC58 acyl CoA thioester hydrolase NP_273965.1 937517 R 122586 CDS YP_008920708.1 566328921 903047 complement(939548..940222) 1 NC_003112.2 opacity protein 940222 903047 NMB0926 Neisseria meningitidis MC58 opacity protein YP_008920708.1 939548 R 122586 CDS NP_273966.1 15676821 903048 941878..942810 1 NC_003112.2 identified by similarity to EGAD:23177; match to protein family HMM PF00561; match to protein family HMM TIGR01249; proline iminopeptidase 942810 pip 903048 pip Neisseria meningitidis MC58 proline iminopeptidase NP_273966.1 941878 D 122586 CDS NP_273967.1 15676822 903049 complement(942867..944063) 1 NC_003112.2 hypothetical protein 944063 903049 NMB0928 Neisseria meningitidis MC58 hypothetical protein NP_273967.1 942867 R 122586 CDS NP_273968.1 15676823 903050 complement(944072..944947) 1 NC_003112.2 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 944947 dapA 903050 dapA Neisseria meningitidis MC58 dihydrodipicolinate synthase NP_273968.1 944072 R 122586 CDS NP_273969.1 15676824 903051 945407..946798 1 NC_003112.2 identified by similarity to EGAD:36665; match to protein family HMM PF00860; match to protein family HMM TIGR00801; xanthine/uracil permease 946798 903051 NMB0930 Neisseria meningitidis MC58 xanthine/uracil permease NP_273969.1 945407 D 122586 CDS NP_273970.1 15676825 903052 complement(946860..947612) 1 NC_003112.2 identified by similarity to EGAD:20604; match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase 947612 903052 NMB0931 Neisseria meningitidis MC58 RNA methyltransferase NP_273970.1 946860 R 122586 CDS NP_273971.1 15676826 903053 complement(947679..948167) 1 NC_003112.2 identified by similarity to EGAD:45828; match to protein family HMM PF04306; hypothetical protein 948167 903053 NMB0932 Neisseria meningitidis MC58 hypothetical protein NP_273971.1 947679 R 122586 CDS NP_273972.1 15676827 903054 complement(948172..948891) 1 NC_003112.2 identified by similarity to EGAD:22440; match to protein family HMM PF00383; match to protein family HMM PF04994; cytidine and deoxycytidylate deaminase 948891 903054 NMB0933 Neisseria meningitidis MC58 cytidine and deoxycytidylate deaminase NP_273972.1 948172 R 122586 CDS NP_273973.1 15676828 903055 complement(948895..949836) 1 NC_003112.2 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 949836 miaA 903055 miaA Neisseria meningitidis MC58 tRNA delta(2)-isopentenylpyrophosphate transferase NP_273973.1 948895 R 122586 CDS YP_008920709.1 566328922 17925333 950635..951783 1 NC_003112.2 hypothetical protein 951783 17925333 NMB0935a Neisseria meningitidis MC58 hypothetical protein YP_008920709.1 950635 D 122586 CDS NP_273975.1 15676830 903057 951826..952386 1 NC_003112.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 952386 efp 903057 efp Neisseria meningitidis MC58 elongation factor P NP_273975.1 951826 D 122586 CDS NP_273976.1 15676831 903058 complement(952437..953273) 1 NC_003112.2 hypothetical protein 953273 903058 NMB0938 Neisseria meningitidis MC58 hypothetical protein NP_273976.1 952437 R 122586 CDS NP_273977.1 15676832 903059 complement(953390..953971) 1 NC_003112.2 identified by similarity to EGAD:148309; match to protein family HMM PF07021; match to protein family HMM TIGR02081; hypothetical protein 953971 903059 NMB0939 Neisseria meningitidis MC58 hypothetical protein NP_273977.1 953390 R 122586 CDS NP_273978.1 15676833 903060 complement(953968..955107) 1 NC_003112.2 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 955107 metX 903060 metX Neisseria meningitidis MC58 homoserine O-acetyltransferase NP_273978.1 953968 R 122586 CDS NP_273979.1 15676834 903061 complement(955669..955794) 1 NC_003112.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 955794 rpmJ 903061 rpmJ Neisseria meningitidis MC58 50S ribosomal protein L36 NP_273979.1 955669 R 122586 CDS NP_273980.1 15676835 903062 complement(955794..956069) 1 NC_003112.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 956069 rpmE2 903062 rpmE2 Neisseria meningitidis MC58 50S ribosomal protein L31 NP_273980.1 955794 R 122586 CDS NP_273981.1 15676836 903063 956269..957147 1 NC_003112.2 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 957147 metF 903063 metF Neisseria meningitidis MC58 5,10-methylenetetrahydrofolate reductase NP_273981.1 956269 D 122586 CDS NP_273982.1 15676837 903064 957285..959561 1 NC_003112.2 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 959561 metH 903064 metH Neisseria meningitidis MC58 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_273982.1 957285 D 122586 CDS NP_273984.1 15676839 903066 959840..960577 1 NC_003112.2 identified by similarity to EGAD:48455; match to protein family HMM PF00462; match to protein family HMM PF00578; match to protein family HMM TIGR02190; peroxiredoxin 2 family protein/glutaredoxin 960577 903066 NMB0946 Neisseria meningitidis MC58 peroxiredoxin 2 family protein/glutaredoxin NP_273984.1 959840 D 122586 CDS NP_273985.1 15676840 903067 960826..962229 1 NC_003112.2 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 962229 903067 NMB0947 Neisseria meningitidis MC58 dihydrolipoamide dehydrogenase NP_273985.1 960826 D 122586 CDS NP_273986.1 15676841 903068 962508..962885 1 NC_003112.2 identified by similarity to GP:3273343; match to protein family HMM PF01127; succinate dehydrogenase, cytochrome b556 subunit 962885 sdhC 903068 sdhC Neisseria meningitidis MC58 succinate dehydrogenase, cytochrome b556 subunit NP_273986.1 962508 D 122586 CDS NP_273987.1 15676842 903069 962879..963220 1 NC_003112.2 identified by similarity to GP:3273344; succinate dehydrogenase, hydrophobic membrane anchor protein 963220 sdhD 903069 sdhD Neisseria meningitidis MC58 succinate dehydrogenase, hydrophobic membrane anchor protein NP_273987.1 962879 D 122586 CDS NP_273988.1 15676843 903070 963223..964986 1 NC_003112.2 identified by similarity to GP:3273345; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; succinate dehydrogenase, flavoprotein subunit 964986 sdhA 903070 sdhA Neisseria meningitidis MC58 succinate dehydrogenase, flavoprotein subunit NP_273988.1 963223 D 122586 CDS NP_273989.1 15676844 903071 965106..965813 1 NC_003112.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 965813 sdhB 903071 sdhB Neisseria meningitidis MC58 succinate dehydrogenase iron-sulfur subunit NP_273989.1 965106 D 122586 CDS NP_273990.1 15676845 903072 965817..966065 1 NC_003112.2 identified by similarity to EGAD:36673; match to protein family HMM PF03937; hypothetical protein 966065 903072 NMB0952 Neisseria meningitidis MC58 hypothetical protein NP_273990.1 965817 D 122586 CDS NP_273991.1 15676846 903073 966062..966145 1 NC_003112.2 hypothetical protein 966145 903073 NMB0953 Neisseria meningitidis MC58 hypothetical protein NP_273991.1 966062 D 122586 CDS NP_273992.1 15676847 903074 966177..967460 1 NC_003112.2 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 967460 gltA 903074 gltA Neisseria meningitidis MC58 type II citrate synthase NP_273992.1 966177 D 122586 CDS NP_273993.1 15676848 903075 967665..970493 1 NC_003112.2 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 970493 sucA 903075 sucA Neisseria meningitidis MC58 2-oxoglutarate dehydrogenase E1 NP_273993.1 967665 D 122586 CDS NP_273994.1 15676849 903076 970593..971774 1 NC_003112.2 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 971774 sucB 903076 sucB Neisseria meningitidis MC58 dihydrolipoamide succinyltransferase NP_273994.1 970593 D 122586 CDS NP_273995.1 15676850 903077 972139..973572 1 NC_003112.2 E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 973572 lpdA1 903077 lpdA1 Neisseria meningitidis MC58 dihydrolipoamide dehydrogenase NP_273995.1 972139 D 122586 CDS NP_273996.1 15676851 903078 973697..973984 1 NC_003112.2 hypothetical protein 973984 903078 NMB0958 Neisseria meningitidis MC58 hypothetical protein NP_273996.1 973697 D 122586 CDS NP_273997.1 15676852 903079 974083..975249 1 NC_003112.2 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 975249 sucC 903079 sucC Neisseria meningitidis MC58 succinyl-CoA synthetase subunit beta NP_273997.1 974083 D 122586 CDS NP_273998.1 15676853 903080 975260..976150 1 NC_003112.2 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 976150 sucD 903080 sucD Neisseria meningitidis MC58 succinyl-CoA synthetase subunit alpha NP_273998.1 975260 D 122586 CDS NP_273999.1 15676854 903081 complement(976710..978305) 1 NC_003112.2 identified by similarity to GP:3139107; funZ protein 978305 funZ 903081 funZ Neisseria meningitidis MC58 funZ protein NP_273999.1 976710 R 122586 CDS NP_274000.1 15676855 903082 complement(978339..981188) 1 NC_003112.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 981188 uvrA 903082 uvrA Neisseria meningitidis MC58 excinuclease ABC subunit A NP_274000.1 978339 R 122586 CDS NP_274001.1 15676856 903083 981343..982140 1 NC_003112.2 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 982140 903083 NMB0963 Neisseria meningitidis MC58 phosphatidylserine decarboxylase NP_274001.1 981343 D 122586 CDS NP_274002.1 15676857 903084 complement(983265..985541) 1 NC_003112.2 identified by similarity to GP:2114321; match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 985541 903084 NMB0964 Neisseria meningitidis MC58 TonB-dependent receptor NP_274002.1 983265 R 122586 CDS NP_274003.1 15676858 903085 complement(985599..985871) 1 NC_003112.2 hypothetical protein 985871 903085 NMB0965 Neisseria meningitidis MC58 hypothetical protein NP_274003.1 985599 R 122586 CDS NP_274004.1 15676859 903086 985963..986553 1 NC_003112.2 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 986553 pabA 903086 pabA Neisseria meningitidis MC58 anthranilate synthase component II NP_274004.1 985963 D 122586 CDS NP_274005.1 15676860 903087 986617..987675 1 NC_003112.2 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 987675 trpD 903087 trpD Neisseria meningitidis MC58 anthranilate phosphoribosyltransferase NP_274005.1 986617 D 122586 CDS NP_274006.1 15676861 903088 987683..987772 1 NC_003112.2 hypothetical protein 987772 903088 NMB0968 Neisseria meningitidis MC58 hypothetical protein NP_274006.1 987683 D 122586 CDS YP_008920710.1 566328923 903090 988452..989486 1 NC_003112.2 replication initiation factor 989486 903090 NMB0970 Neisseria meningitidis MC58 replication initiation factor YP_008920710.1 988452 D 122586 CDS NP_274008.1 15676863 903091 989531..989821 1 NC_003112.2 hypothetical protein 989821 903091 NMB0971 Neisseria meningitidis MC58 hypothetical protein NP_274008.1 989531 D 122586 CDS NP_274009.1 15676864 903092 989826..990023 1 NC_003112.2 hypothetical protein 990023 903092 NMB0972 Neisseria meningitidis MC58 hypothetical protein NP_274009.1 989826 D 122586 CDS NP_274010.1 15676865 903093 990031..990315 1 NC_003112.2 hypothetical protein 990315 903093 NMB0973 Neisseria meningitidis MC58 hypothetical protein NP_274010.1 990031 D 122586 CDS NP_274011.1 15676866 903094 990322..990600 1 NC_003112.2 hypothetical protein 990600 903094 NMB0974 Neisseria meningitidis MC58 hypothetical protein NP_274011.1 990322 D 122586 CDS NP_274012.1 15676867 903095 990728..991045 1 NC_003112.2 hypothetical protein 991045 903095 NMB0975 Neisseria meningitidis MC58 hypothetical protein NP_274012.1 990728 D 122586 CDS NP_274013.1 15676868 903096 991029..991424 1 NC_003112.2 identified by similarity to GP:3758871; TspB-like protein 991424 903096 NMB0976 Neisseria meningitidis MC58 TspB-like protein NP_274013.1 991029 D 122586 CDS NP_274014.1 15676869 903097 991714..992187 1 NC_003112.2 identified by similarity to EGAD:90558; match to protein family HMM PF02525; modulator of drug activity B 992187 903097 NMB0977 Neisseria meningitidis MC58 modulator of drug activity B NP_274014.1 991714 D 122586 CDS NP_274015.1 15676870 903098 complement(992395..993780) 1 NC_003112.2 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 993780 pntB 903098 pntB Neisseria meningitidis MC58 pyridine nucleotide transhydrogenase NP_274015.1 992395 R 122586 CDS NP_274016.1 15676871 903099 complement(993860..994243) 1 NC_003112.2 hypothetical protein 994243 903099 NMB0979 Neisseria meningitidis MC58 hypothetical protein NP_274016.1 993860 R 122586 CDS NP_274017.1 15676872 903100 complement(994247..995788) 1 NC_003112.2 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 995788 pntA 903100 pntA Neisseria meningitidis MC58 NAD(P) transhydrogenase subunit alpha NP_274017.1 994247 R 122586 CDS NP_274018.1 15676873 903101 996078..996911 1 NC_003112.2 identified by similarity to EGAD:8936; match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488; phosphoserine phosphatase 996911 serB 903101 serB Neisseria meningitidis MC58 phosphoserine phosphatase NP_274018.1 996078 D 122586 CDS NP_274019.1 15676874 903102 997056..998198 1 NC_003112.2 identified by similarity to EGAD:47927; match to protein family HMM PF00654; chloride channel protein-related protein 998198 903102 NMB0982 Neisseria meningitidis MC58 chloride channel protein-related protein NP_274019.1 997056 D 122586 CDS NP_274020.1 15676875 903103 998362..999942 1 NC_003112.2 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 999942 purH 903103 purH Neisseria meningitidis MC58 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_274020.1 998362 D 122586 CDS NP_274021.1 15676876 903105 1001560..1002057 1 NC_003112.2 identified by similarity to EGAD:143986; match to protein family HMM PF06252; E16-like protein 1002057 903105 NMB0985 Neisseria meningitidis MC58 E16-like protein NP_274021.1 1001560 D 122586 CDS NP_274022.1 15676877 903106 1002035..1002466 1 NC_003112.2 hypothetical protein 1002466 903106 NMB0986 Neisseria meningitidis MC58 hypothetical protein NP_274022.1 1002035 D 122586 CDS NP_274023.1 15676878 903107 1002774..1003319 1 NC_003112.2 identified by similarity to EGAD:21606; N-acetylmuramoyl-L-alanine amidase 1003319 903107 NMB0987 Neisseria meningitidis MC58 N-acetylmuramoyl-L-alanine amidase NP_274023.1 1002774 D 122586 CDS NP_274024.1 15676879 903108 1003316..1003519 1 NC_003112.2 hypothetical protein 1003519 903108 NMB0988 Neisseria meningitidis MC58 hypothetical protein NP_274024.1 1003316 D 122586 CDS NP_274025.1 15676880 903109 1003522..1003686 1 NC_003112.2 hypothetical protein 1003686 903109 NMB0989 Neisseria meningitidis MC58 hypothetical protein NP_274025.1 1003522 D 122586 CDS NP_274026.1 15676881 903110 1003897..1004301 1 NC_003112.2 hypothetical protein 1004301 903110 NMB0990 Neisseria meningitidis MC58 hypothetical protein NP_274026.1 1003897 D 122586 CDS NP_274027.1 15676882 903111 complement(1004343..1005455) 1 NC_003112.2 identified by similarity to EGAD:5595; match to protein family HMM PF01609; IS1106 transposase 1005455 903111 NMB0991 Neisseria meningitidis MC58 IS1106 transposase NP_274027.1 1004343 R 122586 CDS NP_274028.1 15676883 903112 complement(1005589..1007364) 1 NC_003112.2 identified by similarity to EGAD:131908; match to protein family HMM PF03895; match to protein family HMM PF05662; adhesin 1007364 hsf 903112 hsf Neisseria meningitidis MC58 adhesin NP_274028.1 1005589 R 122586 CDS NP_274029.1 15676884 903115 complement(1009296..1009466) 1 NC_003112.2 identified by similarity to EGAD:30834; match to protein family HMM PF00301; rubredoxin 1009466 903115 NMB0993 Neisseria meningitidis MC58 rubredoxin NP_274029.1 1009296 R 122586 CDS NP_274030.1 15676885 903120 complement(1010149..1011240) 1 NC_003112.2 identified by similarity to EGAD:38335; match to protein family HMM PF02771; acyl-CoA dehydrogenase 1011240 903120 NMB0994 Neisseria meningitidis MC58 acyl-CoA dehydrogenase NP_274030.1 1010149 R 122586 CDS NP_274031.2 566328912 903124 complement(1011375..1011923) 1 NC_003112.2 identified by similarity to EGAD:40926; match to protein family HMM TIGR00778; macrophage infectivity potentiator-related protein 1011923 903124 NMB0995 Neisseria meningitidis MC58 macrophage infectivity potentiator-related protein NP_274031.2 1011375 R 122586 CDS NP_274032.1 15676887 903125 complement(1012078..1012449) 1 NC_003112.2 hypothetical protein 1012449 903125 NMB0996 Neisseria meningitidis MC58 hypothetical protein NP_274032.1 1012078 R 122586 CDS NP_274033.1 15676888 903128 complement(1012744..1014435) 1 NC_003112.2 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 1014435 dld 903128 dld Neisseria meningitidis MC58 D-lactate dehydrogenase NP_274033.1 1012744 R 122586 CDS NP_274034.1 15676889 903129 1014959..1018792 1 NC_003112.2 identified by similarity to EGAD:156263; match to protein family HMM PF00037; match to protein family HMM PF01565; match to protein family HMM PF02754; match to protein family HMM PF02913; oxidoreductase 1018792 903129 NMB0998 Neisseria meningitidis MC58 oxidoreductase NP_274034.1 1014959 D 122586 CDS NP_274035.1 15676890 903134 1018973..1019974 1 NC_003112.2 identified by similarity to GP:3046395; match to protein family HMM PF01207; NifR3/SMM1 family protein 1019974 903134 NMB0999 Neisseria meningitidis MC58 NifR3/SMM1 family protein NP_274035.1 1018973 D 122586 CDS NP_274037.1 15676891 903138 complement(1023533..1024408) 1 NC_003112.2 hypothetical protein 1024408 903138 NMB1002 Neisseria meningitidis MC58 hypothetical protein NP_274037.1 1023533 R 122586 CDS NP_274038.1 15676892 903139 complement(1024453..1024749) 1 NC_003112.2 hypothetical protein 1024749 903139 NMB1003 Neisseria meningitidis MC58 hypothetical protein NP_274038.1 1024453 R 122586 CDS NP_274039.1 15676893 903140 complement(1024755..1025000) 1 NC_003112.2 hypothetical protein 1025000 903140 NMB1004 Neisseria meningitidis MC58 hypothetical protein NP_274039.1 1024755 R 122586 CDS NP_274040.1 15676894 903141 complement(1024993..1025217) 1 NC_003112.2 hypothetical protein 1025217 903141 NMB1005 Neisseria meningitidis MC58 hypothetical protein NP_274040.1 1024993 R 122586 CDS NP_274042.1 15676896 903144 1025489..1025860 1 NC_003112.2 identified by similarity to EGAD:6473; match to protein family HMM PF01381; transcriptional regulator 1025860 903144 NMB1007 Neisseria meningitidis MC58 transcriptional regulator NP_274042.1 1025489 D 122586 CDS NP_274043.1 15676897 903146 1025862..1026485 1 NC_003112.2 hypothetical protein 1026485 903146 NMB1008 Neisseria meningitidis MC58 hypothetical protein NP_274043.1 1025862 D 122586 CDS NP_274044.1 15676898 903147 1026478..1026672 1 NC_003112.2 identified by similarity to EGAD:28463; hypothetical protein 1026672 903147 NMB1009 Neisseria meningitidis MC58 hypothetical protein NP_274044.1 1026478 D 122586 CDS NP_274045.1 15676899 903148 1026696..1027259 1 NC_003112.2 hypothetical protein 1027259 903148 NMB1010 Neisseria meningitidis MC58 hypothetical protein NP_274045.1 1026696 D 122586 CDS NP_274046.1 15676900 903149 1027290..1028237 1 NC_003112.2 hypothetical protein 1028237 903149 NMB1011 Neisseria meningitidis MC58 hypothetical protein NP_274046.1 1027290 D 122586 CDS NP_274047.1 15676901 903150 1028322..1028825 1 NC_003112.2 hypothetical protein 1028825 903150 NMB1012 Neisseria meningitidis MC58 hypothetical protein NP_274047.1 1028322 D 122586 CDS NP_274050.1 15676904 903154 complement(1031227..1031832) 1 NC_003112.2 identified by similarity to EGAD:28214; match to protein family HMM PF01713; hypothetical protein 1031832 903154 NMB1016 Neisseria meningitidis MC58 hypothetical protein NP_274050.1 1031227 R 122586 CDS NP_274051.1 15676905 903155 complement(1032557..1033612) 1 NC_003112.2 identified by similarity to EGAD:18583; match to protein family HMM PF01547; match to protein family HMM TIGR00971; sulfate ABC transporter substrate-binding protein 1033612 sbp 903155 sbp Neisseria meningitidis MC58 sulfate ABC transporter substrate-binding protein NP_274051.1 1032557 R 122586 CDS NP_274052.1 15676906 903156 complement(1033718..1034200) 1 NC_003112.2 identified by similarity to EGAD:48492; match to protein family HMM PF00583; hypothetical protein 1034200 903156 NMB1018 Neisseria meningitidis MC58 hypothetical protein NP_274052.1 1033718 R 122586 CDS NP_274053.1 15676907 903157 complement(1034247..1035383) 1 NC_003112.2 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1035383 purK 903157 purK Neisseria meningitidis MC58 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_274053.1 1034247 R 122586 CDS NP_274054.1 15676908 903158 complement(1035380..1035925) 1 NC_003112.2 hypothetical protein 1035925 903158 NMB1020 Neisseria meningitidis MC58 hypothetical protein NP_274054.1 1035380 R 122586 CDS NP_274055.1 15676909 903159 complement(1035922..1037397) 1 NC_003112.2 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1037397 trpE 903159 trpE Neisseria meningitidis MC58 anthranilate synthase component I NP_274055.1 1035922 R 122586 CDS NP_274056.1 15676910 903160 complement(1037517..1038482) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1038482 903160 NMB1022 Neisseria meningitidis MC58 IS30 family transposase NP_274056.1 1037517 R 122586 CDS NP_274057.1 15676911 903161 complement(1038622..1039581) 1 NC_003112.2 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1039581 903161 NMB1023 Neisseria meningitidis MC58 C32 tRNA thiolase NP_274057.1 1038622 R 122586 CDS NP_274058.1 15676912 903162 complement(1039674..1040540) 1 NC_003112.2 identified by similarity to EGAD:36674; match to protein family HMM PF01571; hypothetical protein 1040540 903162 NMB1024 Neisseria meningitidis MC58 hypothetical protein NP_274058.1 1039674 R 122586 CDS NP_274059.1 15676913 903163 complement(1040572..1040934) 1 NC_003112.2 identified by similarity to EGAD:132011; match to protein family HMM PF01042; hypothetical protein 1040934 903163 NMB1025 Neisseria meningitidis MC58 hypothetical protein NP_274059.1 1040572 R 122586 CDS NP_274060.1 15676914 903164 1041009..1041488 1 NC_003112.2 identified by similarity to EGAD:91370; match to protein family HMM PF04073; match to protein family HMM TIGR00011; hypothetical protein 1041488 903164 NMB1026 Neisseria meningitidis MC58 hypothetical protein NP_274060.1 1041009 D 122586 CDS NP_274061.1 15678002 903191 1041511..1042233 1 NC_003112.2 identified by similarity to EGAD:48808; dnaJ protein, truncation 1042233 903191 NMB1027 Neisseria meningitidis MC58 dnaJ protein, truncation NP_274061.1 1041511 D 122586 CDS NP_274062.1 15676915 903165 1042235..1043110 1 NC_003112.2 identified by similarity to EGAD:28370; hypothetical protein 1043110 903165 NMB1028 Neisseria meningitidis MC58 hypothetical protein NP_274062.1 1042235 D 122586 CDS NP_274063.1 15676916 903166 complement(1043182..1044579) 1 NC_003112.2 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1044579 aspA 903166 aspA Neisseria meningitidis MC58 aspartate ammonia-lyase NP_274063.1 1043182 R 122586 CDS NP_274064.1 15676917 903167 complement(1045040..1045603) 1 NC_003112.2 identified by similarity to EGAD:89838; match to protein family HMM PF04264; hypothetical protein 1045603 903167 NMB1030 Neisseria meningitidis MC58 hypothetical protein NP_274064.1 1045040 R 122586 CDS NP_274065.1 15676918 903168 complement(1045766..1046836) 1 NC_003112.2 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1046836 leuB 903168 leuB Neisseria meningitidis MC58 3-isopropylmalate dehydrogenase NP_274065.1 1045766 R 122586 CDS NP_274066.1 15676919 903169 complement(1046870..1047601) 1 NC_003112.2 identified by similarity to EGAD:15581; type II restriction enzyme NlaIV 1047601 nlaIVR 903169 nlaIVR Neisseria meningitidis MC58 type II restriction enzyme NlaIV NP_274066.1 1046870 R 122586 CDS NP_274067.1 15676920 903170 complement(1047617..1048888) 1 NC_003112.2 identified by similarity to EGAD:19644; match to protein family HMM PF00145; match to protein family HMM TIGR00675; modification methylase NlaIV 1048888 903170 NMB1033 Neisseria meningitidis MC58 modification methylase NlaIV NP_274067.1 1047617 R 122586 CDS NP_274068.1 15676921 903171 complement(1049063..1049704) 1 NC_003112.2 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1049704 leuD 903171 leuD Neisseria meningitidis MC58 isopropylmalate isomerase small subunit NP_274068.1 1049063 R 122586 CDS NP_274069.1 15676922 903172 complement(1049766..1050020) 1 NC_003112.2 hypothetical protein 1050020 903172 NMB1035 Neisseria meningitidis MC58 hypothetical protein NP_274069.1 1049766 R 122586 CDS NP_274070.1 15676923 903173 complement(1050117..1051526) 1 NC_003112.2 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1051526 leuC 903173 leuC Neisseria meningitidis MC58 isopropylmalate isomerase large subunit NP_274070.1 1050117 R 122586 CDS NP_274071.1 15676924 903174 1051786..1053135 1 NC_003112.2 identified by similarity to EGAD:41093; match to protein family HMM TIGR02049; glutamate--cysteine ligase 1053135 gshA 903174 gshA Neisseria meningitidis MC58 glutamate--cysteine ligase NP_274071.1 1051786 D 122586 CDS NP_274072.1 15676925 903175 1053258..1053935 1 NC_003112.2 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1053935 radC 903175 radC Neisseria meningitidis MC58 DNA repair protein RadC NP_274072.1 1053258 D 122586 CDS NP_274073.1 15676926 903176 1054008..1054733 1 NC_003112.2 identified by similarity to EGAD:29365; match to protein family HMM PF02677; hypothetical protein 1054733 903176 NMB1039 Neisseria meningitidis MC58 hypothetical protein NP_274073.1 1054008 D 122586 CDS NP_274074.1 15676927 903177 1054886..1056166 1 NC_003112.2 hypothetical protein 1056166 903177 NMB1040 Neisseria meningitidis MC58 hypothetical protein NP_274074.1 1054886 D 122586 CDS NP_274075.1 15678003 903190 1056171..1057349 1 NC_003112.2 identified by similarity to EGAD:6528; GTP-binding protein 1057349 903190 NMB1041 Neisseria meningitidis MC58 GTP-binding protein NP_274075.1 1056171 D 122586 CDS NP_274076.1 15676928 903178 1057346..1059817 1 NC_003112.2 identified by similarity to EGAD:135627; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; cation transporter E1-E2 family ATPase 1059817 903178 NMB1042 Neisseria meningitidis MC58 cation transporter E1-E2 family ATPase NP_274076.1 1057346 D 122586 CDS NP_274078.1 15676930 903181 complement(1060578..1061354) 1 NC_003112.2 identified by similarity to EGAD:21243; match to protein family HMM PF00175; ferredoxin--NADP reductase 1061354 fpr-1 903181 fpr-1 Neisseria meningitidis MC58 ferredoxin--NADP reductase NP_274078.1 1060578 R 122586 CDS NP_274079.1 15676931 903182 complement(1061542..1062336) 1 NC_003112.2 hypothetical protein 1062336 903182 NMB1045 Neisseria meningitidis MC58 hypothetical protein NP_274079.1 1061542 R 122586 CDS NP_274080.1 15676932 903183 complement(1062382..1063791) 1 NC_003112.2 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1063791 thrC 903183 thrC Neisseria meningitidis MC58 threonine synthase NP_274080.1 1062382 R 122586 CDS NP_274081.1 15676933 903184 complement(1063864..1064235) 1 NC_003112.2 hypothetical protein 1064235 903184 NMB1047 Neisseria meningitidis MC58 hypothetical protein NP_274081.1 1063864 R 122586 CDS NP_274082.1 15676934 903185 complement(1064487..1065956) 1 NC_003112.2 hypothetical protein 1065956 903185 NMB1048 Neisseria meningitidis MC58 hypothetical protein NP_274082.1 1064487 R 122586 CDS NP_274083.1 15676935 903186 1066212..1067126 1 NC_003112.2 identified by similarity to EGAD:14640; match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator 1067126 903186 NMB1049 Neisseria meningitidis MC58 transcriptional regulator NP_274083.1 1066212 D 122586 CDS NP_274084.1 15676936 903187 complement(1067585..1068550) 1 NC_003112.2 identified by similarity to EGAD:18338; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1068550 903187 NMB1050 Neisseria meningitidis MC58 IS30 family transposase NP_274084.1 1067585 R 122586 CDS NP_274085.1 15676937 903188 complement(1068672..1070582) 1 NC_003112.2 identified by similarity to EGAD:28306; match to protein family HMM PF00005; ABC transporter ATP-binding protein 1070582 903188 NMB1051 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274085.1 1068672 R 122586 CDS NP_274086.1 15676938 903189 complement(1070601..1071245) 1 NC_003112.2 identified by similarity to EGAD:14096; match to protein family HMM PF00597; dedA protein 1071245 dedA 903189 dedA Neisseria meningitidis MC58 dedA protein NP_274086.1 1070601 R 122586 CDS NP_274087.1 15676939 903235 complement(1071409..1072227) 1 NC_003112.2 identified by similarity to GP:1177565; match to protein family HMM PF07239; class 5 outer membrane protein 1072227 opc 903235 opc Neisseria meningitidis MC58 class 5 outer membrane protein NP_274087.1 1071409 R 122586 CDS NP_274088.2 566328924 903179 complement(1073023..1074045) 1 NC_003112.2 transposase 1074045 903179 NMB1054 Neisseria meningitidis MC58 transposase NP_274088.2 1073023 R 122586 CDS NP_274089.1 15676940 903374 complement(1074262..1075512) 1 NC_003112.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1075512 glyA 903374 glyA Neisseria meningitidis MC58 serine hydroxymethyltransferase NP_274089.1 1074262 R 122586 CDS NP_274091.1 15676942 903474 complement(1075994..1077814) 1 NC_003112.2 identified by similarity to EGAD:161107; match to protein family HMM PF01019; match to protein family HMM TIGR00066; gamma-glutamyltranspeptidase 1077814 ggt 903474 ggt Neisseria meningitidis MC58 gamma-glutamyltranspeptidase NP_274091.1 1075994 R 122586 CDS NP_274092.1 15676943 903476 1078543..1078761 1 NC_003112.2 identified by similarity to EGAD:89718; match to protein family HMM PF04325; hypothetical protein 1078761 903476 NMB1059 Neisseria meningitidis MC58 hypothetical protein NP_274092.1 1078543 D 122586 CDS NP_274093.1 15676944 903477 complement(1078904..1079878) 1 NC_003112.2 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1079878 fbp 903477 fbp Neisseria meningitidis MC58 fructose-1,6-bisphosphatase NP_274093.1 1078904 R 122586 CDS NP_274094.1 15676945 903478 complement(1080124..1080969) 1 NC_003112.2 identified by similarity to EGAD:17919; match to protein family HMM PF04378; hypothetical protein 1080969 903478 NMB1061 Neisseria meningitidis MC58 hypothetical protein NP_274094.1 1080124 R 122586 CDS NP_274095.1 15676946 903479 complement(1081046..1081648) 1 NC_003112.2 identified by similarity to EGAD:155868; match to protein family HMM PF02660; match to protein family HMM TIGR00023; hypothetical protein 1081648 903479 NMB1062 Neisseria meningitidis MC58 hypothetical protein NP_274095.1 1081046 R 122586 CDS NP_274096.1 15676947 903480 1081704..1082060 1 NC_003112.2 identified by similarity to EGAD:36572; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; dihydroneopterin aldolase 1082060 folB 903480 folB Neisseria meningitidis MC58 dihydroneopterin aldolase NP_274096.1 1081704 D 122586 CDS NP_274097.1 15676948 903481 1082094..1082630 1 NC_003112.2 identified by similarity to EGAD:45912; match to protein family HMM PF00293; hypothetical protein 1082630 903481 NMB1064 Neisseria meningitidis MC58 hypothetical protein NP_274097.1 1082094 D 122586 CDS NP_274098.1 15676949 903482 complement(1083144..1083503) 1 NC_003112.2 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1083503 crcB 903482 crcB Neisseria meningitidis MC58 camphor resistance protein CrcB NP_274098.1 1083144 R 122586 CDS NP_274099.1 15676950 903483 complement(1083532..1084212) 1 NC_003112.2 hypothetical protein 1084212 903483 NMB1066 Neisseria meningitidis MC58 hypothetical protein NP_274099.1 1083532 R 122586 CDS NP_274100.1 15676951 903485 1084377..1087421 1 NC_003112.2 identified by similarity to EGAD:30442; match to protein family HMM PF01580; cell division protein FtsK 1087421 ftsK-1 903485 ftsK-1 Neisseria meningitidis MC58 cell division protein FtsK NP_274100.1 1084377 D 122586 CDS NP_274101.1 15676952 903486 complement(1087646..1088908) 1 NC_003112.2 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1088908 proA 903486 proA Neisseria meningitidis MC58 gamma-glutamyl phosphate reductase NP_274101.1 1087646 R 122586 CDS NP_274102.1 15676953 903487 complement(1088921..1090030) 1 NC_003112.2 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1090030 proB 903487 proB Neisseria meningitidis MC58 gamma-glutamyl kinase NP_274102.1 1088921 R 122586 CDS NP_274103.1 15676954 903489 1090515..1092068 1 NC_003112.2 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1092068 leuA 903489 leuA Neisseria meningitidis MC58 2-isopropylmalate synthase NP_274103.1 1090515 D 122586 CDS NP_274104.1 15676955 903490 1092163..1092825 1 NC_003112.2 identified by similarity to EGAD:7870; match to protein family HMM PF02810; match to protein family HMM TIGR02292; hypothetical protein 1092825 903490 NMB1071 Neisseria meningitidis MC58 hypothetical protein NP_274104.1 1092163 D 122586 CDS NP_274105.1 15676956 903491 complement(1092908..1093759) 1 NC_003112.2 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1093759 lgt 903491 lgt Neisseria meningitidis MC58 prolipoprotein diacylglyceryl transferase NP_274105.1 1092908 R 122586 CDS NP_274106.1 15676957 903492 complement(1093830..1094960) 1 NC_003112.2 identified by similarity to EGAD:22297; match to protein family HMM PF00246; hypothetical protein 1094960 903492 NMB1073 Neisseria meningitidis MC58 hypothetical protein NP_274106.1 1093830 R 122586 CDS NP_274107.1 15676958 903493 1095130..1096026 1 NC_003112.2 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1096026 argB 903493 argB Neisseria meningitidis MC58 acetylglutamate kinase NP_274107.1 1095130 D 122586 CDS NP_274108.1 15676959 903494 complement(1097672..1098340) 1 NC_003112.2 identified by similarity to GP:2243021; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490; hypothetical protein 1098340 903494 NMB1075 Neisseria meningitidis MC58 hypothetical protein NP_274108.1 1097672 R 122586 CDS NP_274109.1 15676960 903495 complement(1098337..1099005) 1 NC_003112.2 identified by similarity to EGAD:91757; DnaA regulatory inactivator Hda 1099005 903495 NMB1076 Neisseria meningitidis MC58 DnaA regulatory inactivator Hda NP_274109.1 1098337 R 122586 CDS NP_274110.1 15678005 903145 complement(1099110..1099661) 1 NC_003112.2 identified by similarity to EGAD:28455; ABC transporter ATP-binding protein 1099661 903145 NMB1077 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274110.1 1099110 R 122586 CDS NP_274113.1 15676962 903498 1101164..1103149 1 NC_003112.2 identified by similarity to EGAD:143678; bacteriophage transposase 1103149 903498 NMB1081 Neisseria meningitidis MC58 bacteriophage transposase NP_274113.1 1101164 D 122586 CDS NP_274115.1 15676964 903500 1103519..1104691 1 NC_003112.2 identified by similarity to EGAD:28477; bacteriophage DNA transposition protein B 1104691 903500 NMB1083 Neisseria meningitidis MC58 bacteriophage DNA transposition protein B NP_274115.1 1103519 D 122586 CDS NP_274116.1 15676965 903501 1104693..1105214 1 NC_003112.2 hypothetical protein 1105214 903501 NMB1084 Neisseria meningitidis MC58 hypothetical protein NP_274116.1 1104693 D 122586 CDS NP_274117.1 15676966 903502 1105357..1105902 1 NC_003112.2 identified by similarity to EGAD:21606; N-acetylmuramoyl-L-alanine amidase 1105902 903502 NMB1085 Neisseria meningitidis MC58 N-acetylmuramoyl-L-alanine amidase NP_274117.1 1105357 D 122586 CDS YP_008920711.1 566328925 17925334 1106105..1106269 1 NC_003112.2 hypothetical protein 1106269 17925334 NMB1083a Neisseria meningitidis MC58 hypothetical protein YP_008920711.1 1106105 D 122586 CDS NP_274118.1 15676967 903503 1106272..1106508 1 NC_003112.2 hypothetical protein 1106508 903503 NMB1086 Neisseria meningitidis MC58 hypothetical protein NP_274118.1 1106272 D 122586 CDS NP_274120.1 15676969 903505 complement(1107146..1107316) 1 NC_003112.2 identified by similarity to GP:3127075; match to protein family HMM PF07411; hypothetical protein 1107316 903505 NMB1088 Neisseria meningitidis MC58 hypothetical protein NP_274120.1 1107146 R 122586 CDS NP_274121.1 15676970 903506 1107544..1107882 1 NC_003112.2 hypothetical protein 1107882 903506 NMB1089 Neisseria meningitidis MC58 hypothetical protein NP_274121.1 1107544 D 122586 CDS NP_274122.1 15676971 903508 1107894..1108160 1 NC_003112.2 hypothetical protein 1108160 903508 NMB1090 Neisseria meningitidis MC58 hypothetical protein NP_274122.1 1107894 D 122586 CDS NP_274123.1 15676972 903509 1108157..1108354 1 NC_003112.2 hypothetical protein 1108354 903509 NMB1091 Neisseria meningitidis MC58 hypothetical protein NP_274123.1 1108157 D 122586 CDS NP_274124.1 15676973 903510 1108357..1108863 1 NC_003112.2 hypothetical protein 1108863 903510 NMB1092 Neisseria meningitidis MC58 hypothetical protein NP_274124.1 1108357 D 122586 CDS NP_274125.1 15676974 903514 complement(1108860..1109450) 1 NC_003112.2 hypothetical protein 1109450 903514 NMB1093 Neisseria meningitidis MC58 hypothetical protein NP_274125.1 1108860 R 122586 CDS NP_274126.1 15676975 903515 1109535..1111085 1 NC_003112.2 hypothetical protein 1111085 903515 NMB1094 Neisseria meningitidis MC58 hypothetical protein NP_274126.1 1109535 D 122586 CDS NP_274127.1 15676976 903516 1111085..1112653 1 NC_003112.2 identified by similarity to EGAD:28497; match to protein family HMM PF06074; hypothetical protein 1112653 903516 NMB1095 Neisseria meningitidis MC58 hypothetical protein NP_274127.1 1111085 D 122586 CDS NP_274128.1 15676977 903517 1112640..1113935 1 NC_003112.2 identified by similarity to EGAD:28498; match to protein family HMM PF04233; match to protein family HMM TIGR01641; hypothetical protein 1113935 903517 NMB1096 Neisseria meningitidis MC58 hypothetical protein NP_274128.1 1112640 D 122586 CDS NP_274129.1 15676978 903520 1114691..1115752 1 NC_003112.2 identified by similarity to EGAD:28500; I protein 1115752 903520 NMB1098 Neisseria meningitidis MC58 I protein NP_274129.1 1114691 D 122586 CDS NP_274130.1 15676979 903521 complement(1115840..1116805) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1116805 903521 NMB1099 Neisseria meningitidis MC58 IS30 family transposase NP_274130.1 1115840 R 122586 CDS NP_274131.1 15676980 903522 1116833..1117315 1 NC_003112.2 hypothetical protein 1117315 903522 NMB1100 Neisseria meningitidis MC58 hypothetical protein NP_274131.1 1116833 D 122586 CDS NP_274132.1 15676981 903523 1117315..1117737 1 NC_003112.2 identified by similarity to EGAD:28494; match to protein family HMM PF07030; hypothetical protein 1117737 903523 NMB1101 Neisseria meningitidis MC58 hypothetical protein NP_274132.1 1117315 D 122586 CDS NP_274133.1 15676982 903524 1117784..1118377 1 NC_003112.2 hypothetical protein 1118377 903524 NMB1102 Neisseria meningitidis MC58 hypothetical protein NP_274133.1 1117784 D 122586 CDS NP_274134.1 15676983 903525 1118374..1118571 1 NC_003112.2 hypothetical protein 1118571 903525 NMB1103 Neisseria meningitidis MC58 hypothetical protein NP_274134.1 1118374 D 122586 CDS NP_274135.1 15676984 903526 1118574..1119983 1 NC_003112.2 identified by similarity to EGAD:28506; match to protein family HMM PF06274; phage sheath protein 1119983 903526 NMB1104 Neisseria meningitidis MC58 phage sheath protein NP_274135.1 1118574 D 122586 CDS NP_274136.1 15676985 903527 1120048..1120425 1 NC_003112.2 hypothetical protein 1120425 903527 NMB1105 Neisseria meningitidis MC58 hypothetical protein NP_274136.1 1120048 D 122586 CDS NP_274137.1 15676986 903528 1120429..1120794 1 NC_003112.2 hypothetical protein 1120794 903528 NMB1106 Neisseria meningitidis MC58 hypothetical protein NP_274137.1 1120429 D 122586 CDS NP_274138.1 15676987 903529 complement(1121046..1121648) 1 NC_003112.2 hypothetical protein 1121648 903529 NMB1107 Neisseria meningitidis MC58 hypothetical protein NP_274138.1 1121046 R 122586 CDS NP_274139.1 15676988 903530 1121818..1123974 1 NC_003112.2 hypothetical protein 1123974 903530 NMB1108 Neisseria meningitidis MC58 hypothetical protein NP_274139.1 1121818 D 122586 CDS NP_274140.1 15676989 903531 1123974..1125305 1 NC_003112.2 identified by similarity to EGAD:28510; match to protein family HMM PF07157; phage virion protein 1125305 903531 NMB1109 Neisseria meningitidis MC58 phage virion protein NP_274140.1 1123974 D 122586 CDS NP_274141.1 15676990 903532 1125295..1126440 1 NC_003112.2 identified by similarity to EGAD:94050; match to protein family HMM PF06893; tail protein, 43 kDa 1126440 903532 NMB1110 Neisseria meningitidis MC58 tail protein, 43 kDa NP_274141.1 1125295 D 122586 CDS NP_274142.1 15676991 903533 1126437..1127105 1 NC_003112.2 identified by similarity to EGAD:28503; match to protein family HMM PF06890; match to protein family HMM TIGR01644; baseplate assembly protein V 1127105 903533 NMB1111 Neisseria meningitidis MC58 baseplate assembly protein V NP_274142.1 1126437 D 122586 CDS NP_274143.1 15676992 903534 1127206..1127553 1 NC_003112.2 identified by similarity to EGAD:28504; match to protein family HMM PF07409; hypothetical protein 1127553 903534 NMB1112 Neisseria meningitidis MC58 hypothetical protein NP_274143.1 1127206 D 122586 CDS NP_274144.1 15676993 903536 1128618..1129178 1 NC_003112.2 identified by similarity to EGAD:91160; hypothetical protein 1129178 903536 NMB1114 Neisseria meningitidis MC58 hypothetical protein NP_274144.1 1128618 D 122586 CDS NP_274145.1 15676994 903537 1129189..1131162 1 NC_003112.2 identified by similarity to EGAD:68685; match to protein family HMM PF07484; tail fiber protein 1131162 903537 NMB1115 Neisseria meningitidis MC58 tail fiber protein NP_274145.1 1129189 D 122586 CDS NP_274147.2 566328911 903539 complement(1132239..1132541) 1 NC_003112.2 hypothetical protein 1132541 903539 NMB1117 Neisseria meningitidis MC58 hypothetical protein NP_274147.2 1132239 R 122586 CDS NP_274148.1 15676997 903540 complement(1132513..1132800) 1 NC_003112.2 identified by similarity to EGAD:48708; match to protein family HMM PF04365; hypothetical protein 1132800 903540 NMB1118 Neisseria meningitidis MC58 hypothetical protein NP_274148.1 1132513 R 122586 CDS NP_274149.1 15676998 903541 1132880..1133485 1 NC_003112.2 identified by similarity to EGAD:28402; hypothetical protein 1133485 903541 NMB1119 Neisseria meningitidis MC58 hypothetical protein NP_274149.1 1132880 D 122586 CDS NP_274150.1 15676999 903542 1133464..1133760 1 NC_003112.2 hypothetical protein 1133760 903542 NMB1120 Neisseria meningitidis MC58 hypothetical protein NP_274150.1 1133464 D 122586 CDS NP_274153.1 15677001 903545 complement(1135662..1136309) 1 NC_003112.2 hypothetical protein 1136309 903545 NMB1124 Neisseria meningitidis MC58 hypothetical protein NP_274153.1 1135662 R 122586 CDS NP_274154.1 15677002 903546 complement(1136306..1136677) 1 NC_003112.2 hypothetical protein 1136677 903546 NMB1125 Neisseria meningitidis MC58 hypothetical protein NP_274154.1 1136306 R 122586 CDS NP_274155.1 15677003 903547 complement(1136684..1137355) 1 NC_003112.2 hypothetical protein 1137355 903547 NMB1126 Neisseria meningitidis MC58 hypothetical protein NP_274155.1 1136684 R 122586 CDS NP_274156.1 15677004 903548 complement(1137520..1138239) 1 NC_003112.2 identified by similarity to EGAD:6851; match to protein family HMM PF00106; short chain dehydrogenase 1138239 903548 NMB1127 Neisseria meningitidis MC58 short chain dehydrogenase NP_274156.1 1137520 R 122586 CDS NP_274157.1 15677005 903549 complement(1138322..1139635) 1 NC_003112.2 identified by similarity to EGAD:97074; match to protein family HMM PF01593; hypothetical protein 1139635 903549 NMB1128 Neisseria meningitidis MC58 hypothetical protein NP_274157.1 1138322 R 122586 CDS NP_274159.1 15677007 903551 complement(1140033..1140905) 1 NC_003112.2 identified by similarity to EGAD:49612; match to protein family HMM PF00494; phytoene synthase 1140905 903551 NMB1130 Neisseria meningitidis MC58 phytoene synthase NP_274159.1 1140033 R 122586 CDS NP_274160.1 15677008 903552 1141076..1142938 1 NC_003112.2 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 1142938 hscA 903552 hscA Neisseria meningitidis MC58 chaperone protein HscA NP_274160.1 1141076 D 122586 CDS NP_274161.1 15677009 903553 1143015..1143671 1 NC_003112.2 hypothetical protein 1143671 903553 NMB1132 Neisseria meningitidis MC58 hypothetical protein NP_274161.1 1143015 D 122586 CDS NP_274162.1 15677010 903554 1143708..1144469 1 NC_003112.2 identified by similarity to EGAD:1534; similarity to EGAD:91259; match to protein family HMM PF00023; hypothetical protein 1144469 903554 NMB1133 Neisseria meningitidis MC58 hypothetical protein NP_274162.1 1143708 D 122586 CDS NP_274163.1 15677011 903555 1144524..1144865 1 NC_003112.2 identified by similarity to EGAD:19142; match to protein family HMM PF00111; match to protein family HMM TIGR02007; ferredoxin, 2Fe-2S type 1144865 fdx-1 903555 fdx-1 Neisseria meningitidis MC58 ferredoxin, 2Fe-2S type NP_274163.1 1144524 D 122586 CDS NP_274164.1 15677012 903556 1145140..1145283 1 NC_003112.2 hypothetical protein 1145283 903556 NMB1135 Neisseria meningitidis MC58 hypothetical protein NP_274164.1 1145140 D 122586 CDS YP_008920712.1 566328926 17925335 complement(1145288..1145842) 1 NC_003112.2 amino acid permease 1145842 17925335 NMB1135a Neisseria meningitidis MC58 amino acid permease YP_008920712.1 1145288 R 122586 CDS NP_274166.1 15677014 903558 1146055..1146252 1 NC_003112.2 identified by similarity to GP:3046317; match to protein family HMM PF04384; hypothetical protein 1146252 903558 NMB1137 Neisseria meningitidis MC58 hypothetical protein NP_274166.1 1146055 D 122586 CDS NP_274167.1 15677015 903559 complement(1146320..1146721) 1 NC_003112.2 identified by similarity to EGAD:29941; match to protein family HMM PF01479; hypothetical protein 1146721 903559 NMB1138 Neisseria meningitidis MC58 hypothetical protein NP_274167.1 1146320 R 122586 CDS NP_274168.1 15677016 903560 1146933..1147892 1 NC_003112.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1147892 accA-1 903560 accA-1 Neisseria meningitidis MC58 acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_274168.1 1146933 D 122586 CDS YP_338291.1 77358709 903561 1147990..1149270 1 NC_003112.2 identified by similarity to EGAD:90825; match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthetase 1149270 tilS-1 903561 tilS-1 Neisseria meningitidis MC58 tRNA(Ile)-lysidine synthetase YP_338291.1 1147990 D 122586 CDS NP_274169.2 566328910 903562 1149344..1150129 1 NC_003112.2 identified by similarity to EGAD:107730; match to protein family HMM PF00588; RNA methyltransferase 1150129 903562 NMB1141 Neisseria meningitidis MC58 RNA methyltransferase NP_274169.2 1149344 D 122586 CDS NP_274171.1 15677019 903564 1150585..1150950 1 NC_003112.2 hypothetical protein 1150950 903564 NMB1143 Neisseria meningitidis MC58 hypothetical protein NP_274171.1 1150585 D 122586 CDS NP_274172.1 15677020 903565 1150962..1151267 1 NC_003112.2 hypothetical protein 1151267 903565 NMB1144 Neisseria meningitidis MC58 hypothetical protein NP_274172.1 1150962 D 122586 CDS NP_274173.1 15677021 903566 1151329..1152705 1 NC_003112.2 identified by similarity to EGAD:19891; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01081; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 1152705 mpl-1 903566 mpl-1 Neisseria meningitidis MC58 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase NP_274173.1 1151329 D 122586 CDS NP_274174.1 15677022 903567 1152912..1153964 1 NC_003112.2 identified by similarity to EGAD:28044; match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433; biotin synthetase 1153964 bioB-1 903567 bioB-1 Neisseria meningitidis MC58 biotin synthetase NP_274174.1 1152912 D 122586 CDS NP_274175.1 15677023 903568 complement(1154042..1154677) 1 NC_003112.2 hypothetical protein 1154677 903568 NMB1147 Neisseria meningitidis MC58 hypothetical protein NP_274175.1 1154042 R 122586 CDS NP_274177.1 15677025 903570 complement(1154911..1155054) 1 NC_003112.2 hypothetical protein 1155054 903570 NMB1149 Neisseria meningitidis MC58 hypothetical protein NP_274177.1 1154911 R 122586 CDS NP_274178.1 15677026 903571 complement(1155323..1157182) 1 NC_003112.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1157182 ilvD-1 903571 ilvD-1 Neisseria meningitidis MC58 dihydroxy-acid dehydratase NP_274178.1 1155323 R 122586 CDS NP_274179.1 15677027 903572 complement(1157355..1159124) 1 NC_003112.2 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 1159124 cysI-1 903572 cysI-1 Neisseria meningitidis MC58 sulfite reductase subunit beta NP_274179.1 1157355 R 122586 CDS NP_274180.1 15677028 903573 complement(1159151..1160965) 1 NC_003112.2 identified by similarity to EGAD:22695; match to protein family HMM PF00175; match to protein family HMM PF00258; match to protein family HMM PF00667; match to protein family HMM TIGR01931; sulfite reductase (NADPH) flavoprotein, alpha component 1160965 cysJ-1 903573 cysJ-1 Neisseria meningitidis MC58 sulfite reductase (NADPH) flavoprotein, alpha component NP_274180.1 1159151 R 122586 CDS NP_274181.1 15677029 903574 complement(1160962..1162248) 1 NC_003112.2 identified by similarity to EGAD:18882; match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR02034; sulfate adenylyltransferase, subunit 1 1162248 cysN-1 903574 cysN-1 Neisseria meningitidis MC58 sulfate adenylyltransferase, subunit 1 NP_274181.1 1160962 R 122586 CDS NP_274182.1 15677030 903575 complement(1162287..1163210) 1 NC_003112.2 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1163210 cysD-1 903575 cysD-1 Neisseria meningitidis MC58 sulfate adenylyltransferase subunit 2 NP_274182.1 1162287 R 122586 CDS NP_274183.1 15677031 903576 complement(1163248..1163988) 1 NC_003112.2 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 1163988 cysH-1 903576 cysH-1 Neisseria meningitidis MC58 phosphoadenosine phosphosulfate reductase NP_274183.1 1163248 R 122586 CDS NP_274184.1 15677032 903577 complement(1163999..1165450) 1 NC_003112.2 identified by similarity to EGAD:142433; match to protein family HMM PF00590; match to protein family HMM TIGR01469; match to protein family HMM TIGR01470; siroheme synthase 1165450 cysG-1 903577 cysG-1 Neisseria meningitidis MC58 siroheme synthase NP_274184.1 1163999 R 122586 CDS NP_274186.1 15677034 903579 complement(1165747..1166403) 1 NC_003112.2 identified by similarity to EGAD:43078; match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 1166403 903579 NMB1158 Neisseria meningitidis MC58 nickel-dependent hydrogenase, b-type cytochrome subunit NP_274186.1 1165747 R 122586 CDS NP_274187.1 15677035 903580 1166467..1167357 1 NC_003112.2 identified by similarity to GP:3449254; match to protein family HMM PF01256; match to protein family HMM TIGR00196; hypothetical protein 1167357 903580 NMB1159 Neisseria meningitidis MC58 hypothetical protein NP_274187.1 1166467 D 122586 CDS NP_274189.1 15677037 903582 complement(1167698..1168345) 1 NC_003112.2 hypothetical protein 1168345 903582 NMB1162 Neisseria meningitidis MC58 hypothetical protein NP_274189.1 1167698 R 122586 CDS NP_274190.1 15677038 903583 complement(1168342..1168713) 1 NC_003112.2 hypothetical protein 1168713 903583 NMB1163 Neisseria meningitidis MC58 hypothetical protein NP_274190.1 1168342 R 122586 CDS NP_274191.1 15677039 903584 complement(1168720..1169391) 1 NC_003112.2 hypothetical protein 1169391 903584 NMB1164 Neisseria meningitidis MC58 hypothetical protein NP_274191.1 1168720 R 122586 CDS NP_274192.1 15677040 903585 complement(1169556..1170275) 1 NC_003112.2 identified by similarity to EGAD:6851; match to protein family HMM PF00106; short chain dehydrogenase 1170275 903585 NMB1165 Neisseria meningitidis MC58 short chain dehydrogenase NP_274192.1 1169556 R 122586 CDS NP_274193.1 15677041 903586 complement(1170358..1171671) 1 NC_003112.2 identified by similarity to EGAD:97074; match to protein family HMM PF01593; hypothetical protein 1171671 903586 NMB1166 Neisseria meningitidis MC58 hypothetical protein NP_274193.1 1170358 R 122586 CDS NP_274195.1 15677043 903588 complement(1172069..1172941) 1 NC_003112.2 identified by similarity to EGAD:49612; match to protein family HMM PF00494; phytoene synthase 1172941 903588 NMB1168 Neisseria meningitidis MC58 phytoene synthase NP_274195.1 1172069 R 122586 CDS NP_274196.1 15677044 903589 1173112..1174974 1 NC_003112.2 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 1174974 hscA 903589 hscA Neisseria meningitidis MC58 chaperone protein HscA NP_274196.1 1173112 D 122586 CDS NP_274197.1 15677045 903590 1175051..1175707 1 NC_003112.2 hypothetical protein 1175707 903590 NMB1170 Neisseria meningitidis MC58 hypothetical protein NP_274197.1 1175051 D 122586 CDS NP_274198.1 15677046 903591 1175744..1176505 1 NC_003112.2 identified by similarity to EGAD:1534; similarity to EGAD:91259; match to protein family HMM PF00023; hypothetical protein 1176505 903591 NMB1171 Neisseria meningitidis MC58 hypothetical protein NP_274198.1 1175744 D 122586 CDS NP_274199.1 15677047 903592 1176560..1176901 1 NC_003112.2 identified by similarity to EGAD:19142; match to protein family HMM PF00111; match to protein family HMM TIGR02007; ferredoxin, 2Fe-2S type 1176901 fdx-2 903592 fdx-2 Neisseria meningitidis MC58 ferredoxin, 2Fe-2S type NP_274199.1 1176560 D 122586 CDS NP_274200.1 15677048 903593 1177176..1177319 1 NC_003112.2 hypothetical protein 1177319 903593 NMB1173 Neisseria meningitidis MC58 hypothetical protein NP_274200.1 1177176 D 122586 CDS NP_274201.1 15677049 903594 1177411..1178094 1 NC_003112.2 hypothetical protein 1178094 903594 NMB1174 Neisseria meningitidis MC58 hypothetical protein NP_274201.1 1177411 D 122586 CDS NP_274202.1 15677050 903595 1178091..1178288 1 NC_003112.2 identified by similarity to GP:3046317; match to protein family HMM PF04384; hypothetical protein 1178288 903595 NMB1175 Neisseria meningitidis MC58 hypothetical protein NP_274202.1 1178091 D 122586 CDS NP_274203.1 15677051 903596 complement(1178356..1178757) 1 NC_003112.2 identified by similarity to EGAD:29941; match to protein family HMM PF01479; hypothetical protein 1178757 903596 NMB1176 Neisseria meningitidis MC58 hypothetical protein NP_274203.1 1178356 R 122586 CDS NP_274204.1 15677052 903597 1178969..1179928 1 NC_003112.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1179928 accA-2 903597 accA-2 Neisseria meningitidis MC58 acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_274204.1 1178969 D 122586 CDS YP_338292.1 77358707 903598 1180026..1181306 1 NC_003112.2 identified by similarity to EGAD:90825; match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthetase 1181306 tilS-2 903598 tilS-2 Neisseria meningitidis MC58 tRNA(Ile)-lysidine synthetase YP_338292.1 1180026 D 122586 CDS NP_274205.2 566328909 903599 1181380..1182165 1 NC_003112.2 identified by similarity to EGAD:107730; match to protein family HMM PF00588; RNA methyltransferase 1182165 903599 NMB1179 Neisseria meningitidis MC58 RNA methyltransferase NP_274205.2 1181380 D 122586 CDS NP_274207.1 15677055 903601 1182621..1182986 1 NC_003112.2 hypothetical protein 1182986 903601 NMB1181 Neisseria meningitidis MC58 hypothetical protein NP_274207.1 1182621 D 122586 CDS NP_274208.1 15677056 903602 1182998..1183303 1 NC_003112.2 hypothetical protein 1183303 903602 NMB1182 Neisseria meningitidis MC58 hypothetical protein NP_274208.1 1182998 D 122586 CDS NP_274209.1 15677057 903603 1183365..1184741 1 NC_003112.2 identified by similarity to EGAD:19891; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01081; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 1184741 mpl-2 903603 mpl-2 Neisseria meningitidis MC58 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase NP_274209.1 1183365 D 122586 CDS NP_274210.1 15677058 903604 1184948..1186000 1 NC_003112.2 identified by similarity to EGAD:28044; match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433; biotin synthetase 1186000 bioB-2 903604 bioB-2 Neisseria meningitidis MC58 biotin synthetase NP_274210.1 1184948 D 122586 CDS NP_274211.1 15677059 903605 complement(1186078..1186713) 1 NC_003112.2 hypothetical protein 1186713 903605 NMB1185 Neisseria meningitidis MC58 hypothetical protein NP_274211.1 1186078 R 122586 CDS NP_274213.1 15677061 903607 complement(1186947..1187090) 1 NC_003112.2 hypothetical protein 1187090 903607 NMB1187 Neisseria meningitidis MC58 hypothetical protein NP_274213.1 1186947 R 122586 CDS NP_274214.1 15677062 903608 complement(1187359..1189218) 1 NC_003112.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1189218 ilvD-2 903608 ilvD-2 Neisseria meningitidis MC58 dihydroxy-acid dehydratase NP_274214.1 1187359 R 122586 CDS NP_274215.1 15677063 903609 complement(1189391..1191160) 1 NC_003112.2 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 1191160 cysI-2 903609 cysI-2 Neisseria meningitidis MC58 sulfite reductase subunit beta NP_274215.1 1189391 R 122586 CDS NP_274216.1 15677064 903610 complement(1191187..1193001) 1 NC_003112.2 identified by similarity to EGAD:22695; match to protein family HMM PF00175; match to protein family HMM PF00258; match to protein family HMM PF00667; match to protein family HMM TIGR01931; sulfite reductase (NADPH) flavoprotein, alpha component 1193001 cysJ-2 903610 cysJ-2 Neisseria meningitidis MC58 sulfite reductase (NADPH) flavoprotein, alpha component NP_274216.1 1191187 R 122586 CDS NP_274217.1 15677065 903611 complement(1192998..1194284) 1 NC_003112.2 identified by similarity to EGAD:18882; match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR02034; sulfate adenylyltransferase, subunit 1 1194284 cysN-2 903611 cysN-2 Neisseria meningitidis MC58 sulfate adenylyltransferase, subunit 1 NP_274217.1 1192998 R 122586 CDS NP_274218.1 15677066 903612 complement(1194323..1195246) 1 NC_003112.2 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1195246 cysD-2 903612 cysD-2 Neisseria meningitidis MC58 sulfate adenylyltransferase subunit 2 NP_274218.1 1194323 R 122586 CDS NP_274219.1 15677067 903613 complement(1195284..1196024) 1 NC_003112.2 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 1196024 cysH-2 903613 cysH-2 Neisseria meningitidis MC58 phosphoadenosine phosphosulfate reductase NP_274219.1 1195284 R 122586 CDS NP_274220.1 15677068 903614 complement(1196035..1197486) 1 NC_003112.2 identified by similarity to EGAD:142433; match to protein family HMM PF00590; match to protein family HMM TIGR01469; match to protein family HMM TIGR01470; siroheme synthase 1197486 cysG-2 903614 cysG-2 Neisseria meningitidis MC58 siroheme synthase NP_274220.1 1196035 R 122586 CDS NP_274222.1 15677070 903616 complement(1197783..1198439) 1 NC_003112.2 identified by similarity to EGAD:43078; match to protein family HMM PF01292; nickel-dependent hydrogenase, b-type cytochrome subunit 1198439 903616 NMB1196 Neisseria meningitidis MC58 nickel-dependent hydrogenase, b-type cytochrome subunit NP_274222.1 1197783 R 122586 CDS NP_274223.1 15677071 903617 1198503..1199393 1 NC_003112.2 identified by similarity to GP:3449254; match to protein family HMM PF01256; match to protein family HMM TIGR00196; hypothetical protein 1199393 903617 NMB1197 Neisseria meningitidis MC58 hypothetical protein NP_274223.1 1198503 D 122586 CDS NP_274224.1 15677072 903618 1199663..1201474 1 NC_003112.2 identified by similarity to EGAD:24044; match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA 1201474 typA 903618 typA Neisseria meningitidis MC58 GTP-binding protein TypA NP_274224.1 1199663 D 122586 CDS NP_274225.1 15677073 903622 1202310..1204685 1 NC_003112.2 identified by similarity to EGAD:24912; match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease II family protein 1204685 903622 NMB1200 Neisseria meningitidis MC58 ribonuclease II family protein NP_274225.1 1202310 D 122586 CDS NP_274226.1 15677074 903623 complement(1205024..1206487) 1 NC_003112.2 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 1206487 guaB 903623 guaB Neisseria meningitidis MC58 inosine 5'-monophosphate dehydrogenase NP_274226.1 1205024 R 122586 CDS NP_274227.1 15677075 903624 complement(1206814..1207275) 1 NC_003112.2 hypothetical protein 1207275 903624 NMB1202 Neisseria meningitidis MC58 hypothetical protein NP_274227.1 1206814 R 122586 CDS NP_274228.1 15677076 903625 complement(1207366..1209924) 1 NC_003112.2 identified by similarity to EGAD:8965; match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM TIGR01693; protein-PII uridylyltransferase 1209924 glnD 903625 glnD Neisseria meningitidis MC58 protein-PII uridylyltransferase NP_274228.1 1207366 R 122586 CDS NP_274229.1 15677077 903626 complement(1209973..1210293) 1 NC_003112.2 identified by similarity to EGAD:10979; match to protein family HMM PF01381; transcriptional regulator 1210293 903626 NMB1204 Neisseria meningitidis MC58 transcriptional regulator NP_274229.1 1209973 R 122586 CDS NP_274230.1 15677078 903627 complement(1210318..1210464) 1 NC_003112.2 hypothetical protein 1210464 903627 NMB1205 Neisseria meningitidis MC58 hypothetical protein NP_274230.1 1210318 R 122586 CDS NP_274231.1 15677079 903628 complement(1210618..1211091) 1 NC_003112.2 identified by similarity to EGAD:98244; match to protein family HMM PF00210; match to protein family HMM TIGR00754; bacterioferritin B 1211091 bfrB 903628 bfrB Neisseria meningitidis MC58 bacterioferritin B NP_274231.1 1210618 R 122586 CDS NP_274232.1 15677080 903629 complement(1211119..1211583) 1 NC_003112.2 identified by similarity to EGAD:97939; match to protein family HMM PF00210; match to protein family HMM TIGR00754; bacterioferritin A 1211583 bfrA 903629 bfrA Neisseria meningitidis MC58 bacterioferritin A NP_274232.1 1211119 R 122586 CDS NP_274235.1 15677083 903632 1212159..1212626 1 NC_003112.2 identified by similarity to GP:551169; match to protein family HMM PF02794; toxin-activating protein 1212626 903632 NMB1210 Neisseria meningitidis MC58 toxin-activating protein NP_274235.1 1212159 D 122586 CDS NP_274236.1 15677084 903633 complement(1212780..1213022) 1 NC_003112.2 hypothetical protein 1213022 903633 NMB1211 Neisseria meningitidis MC58 hypothetical protein NP_274236.1 1212780 R 122586 CDS NP_274237.1 15677085 903634 complement(1213019..1213357) 1 NC_003112.2 hypothetical protein 1213357 903634 NMB1212 Neisseria meningitidis MC58 hypothetical protein NP_274237.1 1213019 R 122586 CDS NP_274238.1 15677086 903635 complement(1213354..1213716) 1 NC_003112.2 lipoprotein 1213716 903635 NMB1213 Neisseria meningitidis MC58 lipoprotein NP_274238.1 1213354 R 122586 CDS NP_274239.1 15677087 903636 complement(1213713..1220534) 1 NC_003112.2 identified by similarity to GP:2623258; match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01731; match to protein family HMM TIGR01901; hemagglutinin/hemolysin-like protein 1220534 903636 NMB1214 Neisseria meningitidis MC58 hemagglutinin/hemolysin-like protein NP_274239.1 1213713 R 122586 CDS NP_274240.1 15677088 903637 complement(1220694..1220852) 1 NC_003112.2 hypothetical protein 1220852 903637 NMB1215 Neisseria meningitidis MC58 hypothetical protein NP_274240.1 1220694 R 122586 CDS NP_274241.1 15677089 903638 complement(1221044..1222027) 1 NC_003112.2 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1222027 lipA 903638 lipA Neisseria meningitidis MC58 lipoyl synthase NP_274241.1 1221044 R 122586 CDS NP_274242.2 77358711 903639 complement(1222020..1222643) 1 NC_003112.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1222643 lipB 903639 lipB Neisseria meningitidis MC58 lipoate-protein ligase B NP_274242.2 1222020 R 122586 CDS NP_274243.1 15677091 903640 complement(1222645..1222920) 1 NC_003112.2 identified by similarity to EGAD:17261; match to protein family HMM PF04359; hypothetical protein 1222920 903640 NMB1218 Neisseria meningitidis MC58 hypothetical protein NP_274243.1 1222645 R 122586 CDS NP_274244.1 15677092 903641 1223105..1224175 1 NC_003112.2 identified by similarity to EGAD:107342; match to protein family HMM PF01594; transporter 1224175 903641 NMB1219 Neisseria meningitidis MC58 transporter NP_274244.1 1223105 D 122586 CDS NP_274245.1 15677093 903642 complement(1224372..1225319) 1 NC_003112.2 identified by similarity to GP:2984585; match to protein family HMM PF01145; stomatin/Mec-2 family protein 1225319 903642 NMB1220 Neisseria meningitidis MC58 stomatin/Mec-2 family protein NP_274245.1 1224372 R 122586 CDS NP_274246.1 15677094 903643 complement(1225334..1225741) 1 NC_003112.2 hypothetical protein 1225741 903643 NMB1221 Neisseria meningitidis MC58 hypothetical protein NP_274246.1 1225334 R 122586 CDS NP_274247.1 15677095 903644 1225822..1226481 1 NC_003112.2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1226481 ung 903644 ung Neisseria meningitidis MC58 uracil-DNA glycosylase NP_274247.1 1225822 D 122586 CDS NP_274248.1 15677096 903646 complement(1229189..1229590) 1 NC_003112.2 hypothetical protein 1229590 903646 NMB1224 Neisseria meningitidis MC58 hypothetical protein NP_274248.1 1229189 R 122586 CDS NP_274249.1 15677097 903647 complement(1229635..1230150) 1 NC_003112.2 hypothetical protein 1230150 903647 NMB1225 Neisseria meningitidis MC58 hypothetical protein NP_274249.1 1229635 R 122586 CDS NP_274250.1 15677098 903648 complement(1230616..1232538) 1 NC_003112.2 identified by similarity to EGAD:91449; match to protein family HMM PF00005; ABC transporter ATP-binding protein 1232538 903648 NMB1226 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274250.1 1230616 R 122586 CDS NP_274251.1 15677099 903649 complement(1232615..1233010) 1 NC_003112.2 identified by similarity to EGAD:132841; match to protein family HMM PF04635; hypothetical protein 1233010 903649 NMB1227 Neisseria meningitidis MC58 hypothetical protein NP_274251.1 1232615 R 122586 CDS NP_274252.1 15677100 903650 1233183..1234490 1 NC_003112.2 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1234490 metM 903650 metM Neisseria meningitidis MC58 homoserine dehydrogenase NP_274252.1 1233183 D 122586 CDS NP_274253.1 15677101 903651 1234483..1234917 1 NC_003112.2 hypothetical protein 1234917 903651 NMB1229 Neisseria meningitidis MC58 hypothetical protein NP_274253.1 1234483 D 122586 CDS NP_274254.1 15677102 903652 complement(1234976..1235245) 1 NC_003112.2 identified by similarity to EGAD:8583; match to protein family HMM PF00216; DNA-binding protein HU-beta 1235245 hupB 903652 hupB Neisseria meningitidis MC58 DNA-binding protein HU-beta NP_274254.1 1234976 R 122586 CDS NP_274255.1 15677103 903653 complement(1235427..1237889) 1 NC_003112.2 identified by similarity to EGAD:18728; match to protein family HMM PF00004; match to protein family HMM PF02190; match to protein family HMM PF05362; match to protein family HMM TIGR00763; ATP-dependent protease La 1237889 lon 903653 lon Neisseria meningitidis MC58 ATP-dependent protease La NP_274255.1 1235427 R 122586 CDS NP_274257.1 15677105 903655 complement(1239271..1241016) 1 NC_003112.2 identified by similarity to GP:3063663; match to protein family HMM TIGR01447; exodeoxyribonuclease V subunit alpha 1241016 recD 903655 recD Neisseria meningitidis MC58 exodeoxyribonuclease V subunit alpha NP_274257.1 1239271 R 122586 CDS NP_274258.1 15677106 903656 complement(1241084..1241779) 1 NC_003112.2 identified by similarity to EGAD:28534; match to protein family HMM PF00005; match to protein family HMM TIGR02211; ABC transporter ATP-binding protein 1241779 903656 NMB1234 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274258.1 1241084 R 122586 CDS NP_274259.1 15677107 903657 complement(1241772..1243019) 1 NC_003112.2 identified by similarity to EGAD:91112; match to protein family HMM PF02687; match to protein family HMM TIGR02212; hypothetical protein 1243019 903657 NMB1235 Neisseria meningitidis MC58 hypothetical protein NP_274259.1 1241772 R 122586 CDS NP_274260.1 15677108 903658 1243224..1243502 1 NC_003112.2 hypothetical protein 1243502 903658 NMB1236 Neisseria meningitidis MC58 hypothetical protein NP_274260.1 1243224 D 122586 CDS NP_274261.1 15677109 903659 complement(1243558..1244178) 1 NC_003112.2 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1244178 recR 903659 recR Neisseria meningitidis MC58 recombination protein RecR NP_274261.1 1243558 R 122586 CDS NP_274262.1 15677110 903660 complement(1244242..1245780) 1 NC_003112.2 identified by similarity to EGAD:91215; peptidyl-prolyl cis-trans isomerase-like protein 1245780 903660 NMB1238 Neisseria meningitidis MC58 peptidyl-prolyl cis-trans isomerase-like protein NP_274262.1 1244242 R 122586 CDS NP_274263.1 15677111 903661 complement(1245840..1246214) 1 NC_003112.2 identified by similarity to EGAD:10818; match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein 1246214 903661 NMB1239 Neisseria meningitidis MC58 hypothetical protein NP_274263.1 1245840 R 122586 CDS NP_274264.1 15677112 903662 1246364..1247992 1 NC_003112.2 identified by similarity to EGAD:91449; match to protein family HMM PF00005; ABC transporter ATP-binding protein 1247992 903662 NMB1240 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274264.1 1246364 D 122586 CDS NP_274265.1 15677113 903663 1248064..1249317 1 NC_003112.2 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1249317 cca 903663 cca Neisseria meningitidis MC58 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase NP_274265.1 1248064 D 122586 CDS NP_274266.1 15677114 903664 1249540..1249848 1 NC_003112.2 hypothetical protein 1249848 903664 NMB1242 Neisseria meningitidis MC58 hypothetical protein NP_274266.1 1249540 D 122586 CDS NP_274267.1 15677115 903665 1249930..1250961 1 NC_003112.2 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1250961 ruvB 903665 ruvB Neisseria meningitidis MC58 Holliday junction DNA helicase RuvB NP_274267.1 1249930 D 122586 CDS NP_274268.1 15677116 903666 complement(1250984..1251712) 1 NC_003112.2 identified by similarity to EGAD:7745; match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase 1251712 rpe 903666 rpe Neisseria meningitidis MC58 ribulose-phosphate 3-epimerase NP_274268.1 1250984 R 122586 CDS NP_274270.1 15677118 903668 complement(1252469..1253332) 1 NC_003112.2 identified by similarity to EGAD:49377; match to protein family HMM PF05673; hypothetical protein 1253332 903668 NMB1246 Neisseria meningitidis MC58 hypothetical protein NP_274270.1 1252469 R 122586 CDS NP_274271.2 161353785 903669 complement(1253340..1253957) 1 NC_003112.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1253957 ribE 903669 ribE Neisseria meningitidis MC58 riboflavin synthase subunit alpha NP_274271.2 1253340 R 122586 CDS NP_274272.1 15677120 903671 1254939..1256711 1 NC_003112.2 identified by similarity to EGAD:8121; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730; nitrate/nitrite sensory protein NarX 1256711 903671 NMB1249 Neisseria meningitidis MC58 nitrate/nitrite sensory protein NarX NP_274272.1 1254939 D 122586 CDS NP_274273.1 15677121 903672 1256708..1257364 1 NC_003112.2 identified by similarity to EGAD:9926; match to protein family HMM PF00072; match to protein family HMM PF00196; LuxR family transcriptional regulator 1257364 903672 NMB1250 Neisseria meningitidis MC58 LuxR family transcriptional regulator NP_274273.1 1256708 D 122586 CDS NP_274274.1 15677122 903673 complement(1257804..1258769) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1258769 903673 NMB1251 Neisseria meningitidis MC58 IS30 family transposase NP_274274.1 1257804 R 122586 CDS NP_274275.1 15677123 903674 complement(1258918..1259952) 1 NC_003112.2 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1259952 purM 903674 purM Neisseria meningitidis MC58 phosphoribosylaminoimidazole synthetase NP_274275.1 1258918 R 122586 CDS NP_274276.1 15677124 903676 1260710..1261387 1 NC_003112.2 hypothetical protein 1261387 903676 NMB1253 Neisseria meningitidis MC58 hypothetical protein NP_274276.1 1260710 D 122586 CDS NP_274277.1 15677125 903677 1261380..1261973 1 NC_003112.2 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1261973 ribA 903677 ribA Neisseria meningitidis MC58 GTP cyclohydrolase II NP_274277.1 1261380 D 122586 CDS NP_274278.1 15677126 903679 1263766..1264857 1 NC_003112.2 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein 1264857 ribA/B 903679 ribA/B Neisseria meningitidis MC58 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein NP_274278.1 1263766 D 122586 CDS NP_274280.1 15677127 903680 complement(1265774..1267084) 1 NC_003112.2 identified by similarity to EGAD:28582; match to protein family HMM PF00004; recombination factor protein RarA 1267084 903680 NMB1258 Neisseria meningitidis MC58 recombination factor protein RarA NP_274280.1 1265774 R 122586 CDS NP_274281.1 15677128 903681 1267622..1268587 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1268587 903681 NMB1259 Neisseria meningitidis MC58 IS30 family transposase NP_274281.1 1267622 D 122586 CDS NP_274282.1 15677129 903682 complement(1268664..1271603) 1 NC_003112.2 identified by similarity to EGAD:94080; match to protein family HMM PF04851; type III restriction-modification system EcoPI enzyme, subunit res 1271603 res 903682 res Neisseria meningitidis MC58 type III restriction-modification system EcoPI enzyme, subunit res NP_274282.1 1268664 R 122586 CDS NP_274283.1 15677130 903684 complement(1273815..1274372) 1 NC_003112.2 identified by similarity to EGAD:14824; match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase 1274372 903684 NMB1262 Neisseria meningitidis MC58 peptidyl-prolyl cis-trans isomerase NP_274283.1 1273815 R 122586 CDS NP_274284.1 15677131 903685 complement(1274437..1275354) 1 NC_003112.2 identified by similarity to EGAD:156097; match to protein family HMM PF02492; match to protein family HMM PF07683; CobW-like protein 1275354 903685 NMB1263 Neisseria meningitidis MC58 CobW-like protein NP_274284.1 1274437 R 122586 CDS NP_274285.1 15677132 903686 complement(1275537..1275809) 1 NC_003112.2 identified by similarity to EGAD:43984; hypothetical protein 1275809 903686 NMB1264 Neisseria meningitidis MC58 hypothetical protein NP_274285.1 1275537 R 122586 CDS NP_274286.1 15677133 903687 complement(1275806..1276099) 1 NC_003112.2 identified by similarity to EGAD:44606; match to protein family HMM PF01909; hypothetical protein 1276099 903687 NMB1265 Neisseria meningitidis MC58 hypothetical protein NP_274286.1 1275806 R 122586 CDS NP_274287.2 566328908 903688 complement(1276144..1276737) 1 NC_003112.2 identified by similarity to EGAD:6546; zinc uptake regulation protein 1276737 903688 NMB1266 Neisseria meningitidis MC58 zinc uptake regulation protein NP_274287.2 1276144 R 122586 CDS NP_274288.1 15677135 903689 complement(1276691..1277146) 1 NC_003112.2 identified by similarity to EGAD:107998; match to protein family HMM PF01451; low molecular weight protein tyrosine-phosphatase 1277146 903689 NMB1267 Neisseria meningitidis MC58 low molecular weight protein tyrosine-phosphatase NP_274288.1 1276691 R 122586 CDS NP_274289.1 15677136 903690 complement(1277271..1278386) 1 NC_003112.2 identified by similarity to EGAD:30688; match to protein family HMM PF02595; match to protein family HMM TIGR00045; hypothetical protein 1278386 903690 NMB1268 Neisseria meningitidis MC58 hypothetical protein NP_274289.1 1277271 R 122586 CDS NP_274290.1 15677137 903691 complement(1278500..1279597) 1 NC_003112.2 hypothetical protein 1279597 903691 NMB1269 Neisseria meningitidis MC58 hypothetical protein NP_274290.1 1278500 R 122586 CDS NP_274291.1 15677138 903692 complement(1279679..1281310) 1 NC_003112.2 identified by similarity to EGAD:132853; hypothetical protein 1281310 903692 NMB1270 Neisseria meningitidis MC58 hypothetical protein NP_274291.1 1279679 R 122586 CDS NP_274292.1 15677139 903693 complement(1281410..1281622) 1 NC_003112.2 identified by similarity to EGAD:28925; match to protein family HMM PF00403; mercury transport periplasmic protein 1281622 903693 NMB1271 Neisseria meningitidis MC58 mercury transport periplasmic protein NP_274292.1 1281410 R 122586 CDS NP_274293.1 15677140 903694 complement(1281660..1281803) 1 NC_003112.2 hypothetical protein 1281803 903694 NMB1272 Neisseria meningitidis MC58 hypothetical protein NP_274293.1 1281660 R 122586 CDS NP_274294.1 15677141 903695 1282253..1283689 1 NC_003112.2 identified by similarity to EGAD:38563; match to protein family HMM PF03062; alginate o-acetyltransferase AlgI 1283689 903695 NMB1273 Neisseria meningitidis MC58 alginate o-acetyltransferase AlgI NP_274294.1 1282253 D 122586 CDS NP_274295.1 15677142 903696 1283700..1284683 1 NC_003112.2 hypothetical protein 1284683 903696 NMB1274 Neisseria meningitidis MC58 hypothetical protein NP_274295.1 1283700 D 122586 CDS YP_008920713.1 566328927 903697 1284680..1285873 1 NC_003112.2 hypothetical protein 1285873 903697 NMB1275 Neisseria meningitidis MC58 hypothetical protein YP_008920713.1 1284680 D 122586 CDS NP_274296.1 15677143 903698 1286160..1287713 1 NC_003112.2 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1287713 fadD-1 903698 fadD-1 Neisseria meningitidis MC58 long-chain-fatty-acid--CoA ligase NP_274296.1 1286160 D 122586 CDS NP_274297.1 15677144 903699 complement(1287803..1289830) 1 NC_003112.2 identified by similarity to EGAD:28684; match to protein family HMM PF02028; match to protein family HMM TIGR00842; BCCT family transporter 1289830 903699 NMB1277 Neisseria meningitidis MC58 BCCT family transporter NP_274297.1 1287803 R 122586 CDS NP_274298.1 15677145 903700 1290119..1292125 1 NC_003112.2 identified by similarity to EGAD:142439; site-specific recombinase 1292125 gcr 903700 gcr Neisseria meningitidis MC58 site-specific recombinase NP_274298.1 1290119 D 122586 CDS NP_274299.1 15677146 903701 complement(1292248..1293357) 1 NC_003112.2 identified by similarity to EGAD:31033; match to protein family HMM TIGR02282; membrane-bound lytic murein transglycosylase B 1293357 903701 NMB1279 Neisseria meningitidis MC58 membrane-bound lytic murein transglycosylase B NP_274299.1 1292248 R 122586 CDS NP_274300.1 15677147 903702 complement(1293559..1294986) 1 NC_003112.2 identified by similarity to EGAD:60787; match to protein family HMM PF00441; very long chain acyl-CoA dehydrogenase-related protein 1294986 903702 NMB1280 Neisseria meningitidis MC58 very long chain acyl-CoA dehydrogenase-related protein NP_274300.1 1293559 R 122586 CDS NP_274301.1 15677148 903703 1295171..1299310 1 NC_003112.2 identified by similarity to EGAD:28258; match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 1299310 mfd 903703 mfd Neisseria meningitidis MC58 transcription-repair coupling factor NP_274301.1 1295171 D 122586 CDS NP_274302.1 15677149 903704 1299459..1299842 1 NC_003112.2 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 1299842 panD 903704 panD Neisseria meningitidis MC58 aspartate alpha-decarboxylase NP_274302.1 1299459 D 122586 CDS NP_274303.1 15677150 903705 1299864..1300706 1 NC_003112.2 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1300706 kdsA 903705 kdsA Neisseria meningitidis MC58 2-dehydro-3-deoxyphosphooctonate aldolase NP_274303.1 1299864 D 122586 CDS NP_274304.1 15677151 903706 1300721..1301161 1 NC_003112.2 hypothetical protein 1301161 903706 NMB1284 Neisseria meningitidis MC58 hypothetical protein NP_274304.1 1300721 D 122586 CDS NP_274305.1 15677152 903707 1301209..1302495 1 NC_003112.2 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1302495 eno 903707 eno Neisseria meningitidis MC58 phosphopyruvate hydratase NP_274305.1 1301209 D 122586 CDS NP_274306.1 15677153 903708 1302509..1302787 1 NC_003112.2 identified by similarity to EGAD:36588; match to protein family HMM PF04977; hypothetical protein 1302787 903708 NMB1286 Neisseria meningitidis MC58 hypothetical protein NP_274306.1 1302509 D 122586 CDS NP_274307.1 15677154 903709 complement(1302828..1303118) 1 NC_003112.2 identified by similarity to EGAD:28315; match to protein family HMM PF00111; ferredoxin 1303118 903709 NMB1287 Neisseria meningitidis MC58 ferredoxin NP_274307.1 1302828 R 122586 CDS NP_274308.2 161353784 903710 complement(1303363..1304496) 1 NC_003112.2 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 1304496 nrdB 903710 nrdB Neisseria meningitidis MC58 ribonucleotide-diphosphate reductase subunit beta NP_274308.2 1303363 R 122586 CDS NP_274309.1 15677156 903711 complement(1304557..1305744) 1 NC_003112.2 identified by similarity to GP:2961291; type II restriction enzyme 1305744 903711 NMB1289 Neisseria meningitidis MC58 type II restriction enzyme NP_274309.1 1304557 R 122586 CDS NP_274310.1 15677157 903712 complement(1305737..1306750) 1 NC_003112.2 identified by similarity to EGAD:7155; match to protein family HMM PF00145; match to protein family HMM TIGR00675; C-5 cytosine-specific DNA-methylase 1306750 903712 NMB1290 Neisseria meningitidis MC58 C-5 cytosine-specific DNA-methylase NP_274310.1 1305737 R 122586 CDS NP_274311.1 15677158 903713 complement(1306808..1309087) 1 NC_003112.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1309087 nrdA 903713 nrdA Neisseria meningitidis MC58 ribonucleotide-diphosphate reductase subunit alpha NP_274311.1 1306808 R 122586 CDS NP_274312.1 15677159 903714 complement(1309244..1309432) 1 NC_003112.2 hypothetical protein 1309432 903714 NMB1292 Neisseria meningitidis MC58 hypothetical protein NP_274312.1 1309244 R 122586 CDS NP_274313.1 15677160 903715 1309601..1309927 1 NC_003112.2 hypothetical protein 1309927 903715 NMB1293 Neisseria meningitidis MC58 hypothetical protein NP_274313.1 1309601 D 122586 CDS NP_274314.1 15677161 903716 complement(1310238..1311005) 1 NC_003112.2 identified by similarity to EGAD:40820; match to protein family HMM PF01553; match to protein family HMM TIGR00530; 1-acyl-sn-glycerol-3-phosphate acyltransferase 1311005 plsC 903716 plsC Neisseria meningitidis MC58 1-acyl-sn-glycerol-3-phosphate acyltransferase NP_274314.1 1310238 R 122586 CDS NP_274315.1 15677162 903717 complement(1311093..1311920) 1 NC_003112.2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1311920 mutM 903717 mutM Neisseria meningitidis MC58 formamidopyrimidine-DNA glycosylase NP_274315.1 1311093 R 122586 CDS NP_274316.1 15677163 903718 complement(1311972..1312637) 1 NC_003112.2 hypothetical protein 1312637 903718 NMB1296 Neisseria meningitidis MC58 hypothetical protein NP_274316.1 1311972 R 122586 CDS NP_274317.1 15677164 903719 1312816..1314792 1 NC_003112.2 identified by similarity to EGAD:8903; match to protein family HMM PF01464; match to protein family HMM PF01476; match to protein family HMM PF06474; membrane-bound lytic murein transglycosylase D 1314792 903719 NMB1297 Neisseria meningitidis MC58 membrane-bound lytic murein transglycosylase D NP_274317.1 1312816 D 122586 CDS NP_274318.1 15677165 903720 1314860..1315552 1 NC_003112.2 identified by similarity to EGAD:165416; match to protein family HMM PF00849; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A 1315552 rsuA 903720 rsuA Neisseria meningitidis MC58 ribosomal small subunit pseudouridine synthase A NP_274318.1 1314860 D 122586 CDS NP_274319.1 15677166 903722 1317739..1318395 1 NC_003112.2 identified by similarity to EGAD:10189; match to protein family HMM PF02224; match to protein family HMM TIGR00017; cytidylate kinase 1318395 cmk 903722 cmk Neisseria meningitidis MC58 cytidylate kinase NP_274319.1 1317739 D 122586 CDS NP_274320.1 15677167 903723 1318551..1320236 1 NC_003112.2 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1320236 rpsA 903723 rpsA Neisseria meningitidis MC58 30S ribosomal protein S1 NP_274320.1 1318551 D 122586 CDS NP_274321.1 15677168 903724 1320247..1320561 1 NC_003112.2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1320561 ihfB 903724 ihfB Neisseria meningitidis MC58 integration host factor subunit beta NP_274321.1 1320247 D 122586 CDS NP_274322.1 15677169 903725 complement(1320912..1321319) 1 NC_003112.2 identified by similarity to EGAD:28824; match to protein family HMM PF00376; MerR family transcriptional regulator 1321319 903725 NMB1303 Neisseria meningitidis MC58 MerR family transcriptional regulator NP_274322.1 1320912 R 122586 CDS NP_274323.1 15677170 903726 1321440..1322576 1 NC_003112.2 identified by similarity to EGAD:28823; match to protein family HMM PF00107; alcohol dehydrogenase 1322576 903726 NMB1304 Neisseria meningitidis MC58 alcohol dehydrogenase NP_274323.1 1321440 D 122586 CDS NP_274324.1 15677171 903727 1322585..1323412 1 NC_003112.2 identified by similarity to EGAD:28822; match to protein family HMM PF00756; esterase D 1323412 903727 NMB1305 Neisseria meningitidis MC58 esterase D NP_274324.1 1322585 D 122586 CDS NP_274325.1 15677172 903728 1323803..1324954 1 NC_003112.2 identified by similarity to EGAD:30243; match to protein family HMM PF03969; hypothetical protein 1324954 903728 NMB1306 Neisseria meningitidis MC58 hypothetical protein NP_274325.1 1323803 D 122586 CDS NP_274326.1 15677173 903729 1325013..1325438 1 NC_003112.2 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1325438 ndk 903729 ndk Neisseria meningitidis MC58 nucleoside diphosphate kinase NP_274326.1 1325013 D 122586 CDS NP_274327.1 15677174 903730 1325581..1326675 1 NC_003112.2 identified by similarity to EGAD:39884; match to protein family HMM PF04055; match to protein family HMM TIGR00048; hypothetical protein 1326675 903730 NMB1308 Neisseria meningitidis MC58 hypothetical protein NP_274327.1 1325581 D 122586 CDS NP_274328.1 15677175 903731 1326678..1327439 1 NC_003112.2 identified by similarity to EGAD:39885; match to protein family HMM PF00515; match to protein family HMM TIGR02521; fimbrial biogenesis and twitching motility protein 1327439 903731 NMB1309 Neisseria meningitidis MC58 fimbrial biogenesis and twitching motility protein NP_274328.1 1326678 D 122586 CDS NP_274329.1 15677176 903732 1327455..1328720 1 NC_003112.2 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1328720 ispG 903732 ispG Neisseria meningitidis MC58 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_274329.1 1327455 D 122586 CDS NP_274331.1 15677178 903734 complement(1329163..1329693) 1 NC_003112.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1329693 clpP 903734 clpP Neisseria meningitidis MC58 ATP-dependent Clp protease proteolytic subunit NP_274331.1 1329163 R 122586 CDS NP_274332.1 15677179 903735 complement(1329873..1331186) 1 NC_003112.2 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1331186 tig 903735 tig Neisseria meningitidis MC58 trigger factor NP_274332.1 1329873 R 122586 CDS NP_274333.1 15677180 903736 complement(1331391..1333829) 1 NC_003112.2 identified by similarity to EGAD:30442; match to protein family HMM PF01580; cell division protein FtsK 1333829 ftsK-2 903736 ftsK-2 Neisseria meningitidis MC58 cell division protein FtsK NP_274333.1 1331391 R 122586 CDS NP_274334.1 15677181 903737 1334052..1335263 1 NC_003112.2 identified by similarity to EGAD:28228; match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease 1335263 uraA 903737 uraA Neisseria meningitidis MC58 uracil permease NP_274334.1 1334052 D 122586 CDS YP_008920714.1 566328928 17925336 complement(1335315..1335797) 1 NC_003112.2 hypothetical protein 1335797 17925336 NMB1317a Neisseria meningitidis MC58 hypothetical protein YP_008920714.1 1335315 R 122586 CDS NP_274336.1 15677183 903739 1335903..1336307 1 NC_003112.2 hypothetical protein 1336307 903739 NMB1317 Neisseria meningitidis MC58 hypothetical protein NP_274336.1 1335903 D 122586 CDS NP_274337.1 15677184 903740 1336381..1337127 1 NC_003112.2 identified by similarity to EGAD:166539; match to protein family HMM PF01066; match to protein family HMM TIGR00473; CDP-diacylglycerol--serine O-phosphatidyltransferase 1337127 pssA 903740 pssA Neisseria meningitidis MC58 CDP-diacylglycerol--serine O-phosphatidyltransferase NP_274337.1 1336381 D 122586 CDS NP_274339.1 15677186 903742 complement(1338126..1338578) 1 NC_003112.2 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1338578 rplI 903742 rplI Neisseria meningitidis MC58 50S ribosomal protein L9 NP_274339.1 1338126 R 122586 CDS NP_274340.1 15677187 903743 complement(1338595..1338825) 1 NC_003112.2 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1338825 rpsR 903743 rpsR Neisseria meningitidis MC58 30S ribosomal protein S18 NP_274340.1 1338595 R 122586 CDS NP_274341.1 15677188 903744 complement(1338832..1339134) 1 NC_003112.2 identified by similarity to EGAD:22393; primosomal replication protein 1339134 903744 NMB1322 Neisseria meningitidis MC58 primosomal replication protein NP_274341.1 1338832 R 122586 CDS NP_274342.1 15677189 903745 complement(1339135..1339503) 1 NC_003112.2 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1339503 rpsF 903745 rpsF Neisseria meningitidis MC58 30S ribosomal protein S6 NP_274342.1 1339135 R 122586 CDS NP_274343.1 15677190 903746 complement(1339659..1340609) 1 NC_003112.2 identified by similarity to EGAD:28163; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin reductase 1340609 trxB 903746 trxB Neisseria meningitidis MC58 thioredoxin reductase NP_274343.1 1339659 R 122586 CDS NP_274344.1 15677191 903747 1340748..1342910 1 NC_003112.2 identified by similarity to EGAD:98230; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; cation transporter E1-E2 family ATPase 1342910 903747 NMB1325 Neisseria meningitidis MC58 cation transporter E1-E2 family ATPase NP_274344.1 1340748 D 122586 CDS NP_274345.1 15677192 903748 1343007..1344860 1 NC_003112.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1344860 uvrC 903748 uvrC Neisseria meningitidis MC58 excinuclease ABC subunit C NP_274345.1 1343007 D 122586 CDS NP_274346.1 15677193 903749 1345083..1346486 1 NC_003112.2 identified by similarity to EGAD:91374; hypothetical protein 1346486 903749 NMB1327 Neisseria meningitidis MC58 hypothetical protein NP_274346.1 1345083 D 122586 CDS NP_274347.1 15677194 903750 1346608..1347324 1 NC_003112.2 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1347324 trmB 903750 trmB Neisseria meningitidis MC58 tRNA (guanine-N(7)-)-methyltransferase NP_274347.1 1346608 D 122586 CDS NP_274349.1 15677196 903752 complement(1347952..1348314) 1 NC_003112.2 hypothetical protein 1348314 903752 NMB1330 Neisseria meningitidis MC58 hypothetical protein NP_274349.1 1347952 R 122586 CDS NP_274350.1 15677197 903753 complement(1348427..1350454) 1 NC_003112.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1350454 uvrB 903753 uvrB Neisseria meningitidis MC58 excinuclease ABC subunit B NP_274350.1 1348427 R 122586 CDS NP_274351.1 15677198 903754 complement(1350783..1352267) 1 NC_003112.2 identified by similarity to GP:555748; match to protein family HMM PF00595; match to protein family HMM PF03572; match to protein family HMM TIGR00225; carboxy-terminal peptidase 1352267 prc 903754 prc Neisseria meningitidis MC58 carboxy-terminal peptidase NP_274351.1 1350783 R 122586 CDS NP_274352.1 15677199 903755 complement(1352394..1354184) 1 NC_003112.2 identified by similarity to EGAD:27923; match to protein family HMM PF01551; hypothetical protein 1354184 903755 NMB1333 Neisseria meningitidis MC58 hypothetical protein NP_274352.1 1352394 R 122586 CDS NP_274353.1 15677200 903756 1354276..1354512 1 NC_003112.2 hypothetical protein 1354512 903756 NMB1334 Neisseria meningitidis MC58 hypothetical protein NP_274353.1 1354276 D 122586 CDS NP_274354.1 15677201 903757 1354512..1355072 1 NC_003112.2 identified by similarity to EGAD:7971; match to protein family HMM PF05981; creA protein 1355072 creA 903757 creA Neisseria meningitidis MC58 creA protein NP_274354.1 1354512 D 122586 CDS NP_274355.1 15677202 903758 1355074..1355622 1 NC_003112.2 identified by similarity to EGAD:36515; match to protein family HMM PF02622; hypothetical protein 1355622 903758 NMB1336 Neisseria meningitidis MC58 hypothetical protein NP_274355.1 1355074 D 122586 CDS NP_274356.1 15677203 903759 1355615..1356070 1 NC_003112.2 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1356070 903759 NMB1337 Neisseria meningitidis MC58 Holliday junction resolvase-like protein NP_274356.1 1355615 D 122586 CDS NP_274357.1 15677204 903760 complement(1356080..1356736) 1 NC_003112.2 identified by similarity to EGAD:91262; match to protein family HMM PF01557; isomerase 1356736 903760 NMB1338 Neisseria meningitidis MC58 isomerase NP_274357.1 1356080 R 122586 CDS NP_274358.1 15677205 903761 complement(1356799..1358511) 1 NC_003112.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1358511 proS 903761 proS Neisseria meningitidis MC58 prolyl-tRNA synthetase NP_274358.1 1356799 R 122586 CDS NP_274360.1 15677207 903763 1359205..1361868 1 NC_003112.2 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1361868 aceE 903763 aceE Neisseria meningitidis MC58 pyruvate dehydrogenase subunit E1 NP_274360.1 1359205 D 122586 CDS NP_274361.1 15677208 903764 1362017..1363624 1 NC_003112.2 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA; dihydrolipoamide acetyltransferase 1363624 aceF 903764 aceF Neisseria meningitidis MC58 dihydrolipoamide acetyltransferase NP_274361.1 1362017 D 122586 CDS NP_274362.1 15677209 903765 1363718..1364155 1 NC_003112.2 hypothetical protein 1364155 903765 NMB1343 Neisseria meningitidis MC58 hypothetical protein NP_274362.1 1363718 D 122586 CDS NP_274363.1 15677210 903766 1364173..1365957 1 NC_003112.2 identified by similarity to GP:1006678; match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) 1365957 lpdA2 903766 lpdA2 Neisseria meningitidis MC58 dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) NP_274363.1 1364173 D 122586 CDS NP_274364.1 15677211 903767 complement(1366318..1367868) 1 NC_003112.2 hypothetical protein 1367868 903767 NMB1345 Neisseria meningitidis MC58 hypothetical protein NP_274364.1 1366318 R 122586 CDS NP_274365.1 15677212 903769 complement(1370039..1370824) 1 NC_003112.2 identified by similarity to EGAD:15335; match to protein family HMM PF00459; extragenic suppressor protein SuhB 1370824 suhB 903769 suhB Neisseria meningitidis MC58 extragenic suppressor protein SuhB NP_274365.1 1370039 R 122586 CDS NP_274366.1 15677213 903770 1371068..1371883 1 NC_003112.2 identified by similarity to GP:3046324; match to protein family HMM PF00588; match to protein family HMM TIGR00050; RNA methylase 1371883 903770 NMB1348 Neisseria meningitidis MC58 RNA methylase NP_274366.1 1371068 D 122586 CDS NP_274367.1 15677214 903771 1371944..1372801 1 NC_003112.2 hypothetical protein 1372801 903771 NMB1349 Neisseria meningitidis MC58 hypothetical protein NP_274367.1 1371944 D 122586 CDS NP_274368.1 15677215 903772 1373005..1373346 1 NC_003112.2 hypothetical protein 1373346 903772 NMB1350 Neisseria meningitidis MC58 hypothetical protein NP_274368.1 1373005 D 122586 CDS NP_274369.1 15677216 903773 1373694..1374950 1 NC_003112.2 identified by similarity to GP:606223; match to protein family HMM PF01189; SUN-family protein 1374950 903773 NMB1351 Neisseria meningitidis MC58 SUN-family protein NP_274369.1 1373694 D 122586 CDS NP_274370.1 15677217 903774 1375310..1375744 1 NC_003112.2 hypothetical protein 1375744 903774 NMB1352 Neisseria meningitidis MC58 hypothetical protein NP_274370.1 1375310 D 122586 CDS NP_274371.1 15677218 903775 complement(1375792..1377135) 1 NC_003112.2 identified by similarity to EGAD:91347; match to protein family HMM PF00171; aldehyde dehydrogenase 1377135 903775 NMB1353 Neisseria meningitidis MC58 aldehyde dehydrogenase NP_274371.1 1375792 R 122586 CDS NP_274372.1 15677219 903776 complement(1377140..1377793) 1 NC_003112.2 identified by similarity to EGAD:44279; match to protein family HMM PF01914; match to protein family HMM TIGR00427; hypothetical protein 1377793 903776 NMB1354 Neisseria meningitidis MC58 hypothetical protein NP_274372.1 1377140 R 122586 CDS NP_274373.1 15677220 903777 1377944..1378234 1 NC_003112.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1378234 gatC 903777 gatC Neisseria meningitidis MC58 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_274373.1 1377944 D 122586 CDS NP_274374.1 15677221 903778 1378297..1379742 1 NC_003112.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1379742 gatA 903778 gatA Neisseria meningitidis MC58 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_274374.1 1378297 D 122586 CDS NP_274375.1 15677222 903779 1379739..1380671 1 NC_003112.2 identified by similarity to EGAD:28126; match to protein family HMM PF04393; hypothetical protein 1380671 903779 NMB1357 Neisseria meningitidis MC58 hypothetical protein NP_274375.1 1379739 D 122586 CDS NP_274376.1 15677223 903780 1380714..1382144 1 NC_003112.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1382144 gatB 903780 gatB Neisseria meningitidis MC58 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_274376.1 1380714 D 122586 CDS NP_274377.1 15677224 903781 1382356..1383366 1 NC_003112.2 identified by similarity to EGAD:21136; match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF08030; CDP-6-deoxy-delta-3,4-glucoseen reductase 1383366 903781 NMB1359 Neisseria meningitidis MC58 CDP-6-deoxy-delta-3,4-glucoseen reductase NP_274377.1 1382356 D 122586 CDS NP_274378.1 15677225 903782 complement(1383496..1384128) 1 NC_003112.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1384128 pdxH 903782 pdxH Neisseria meningitidis MC58 pyridoxamine 5'-phosphate oxidase NP_274378.1 1383496 R 122586 CDS NP_274379.1 15677226 903783 1384350..1385402 1 NC_003112.2 identified by similarity to GP:602963; match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; hypothetical protein 1385402 903783 NMB1361 Neisseria meningitidis MC58 hypothetical protein NP_274379.1 1384350 D 122586 CDS NP_274380.1 15677227 903784 complement(1385471..1387012) 1 NC_003112.2 identified by similarity to EGAD:105396; match to protein family HMM PF07690; oxalate/formate antiporter 1387012 903784 NMB1362 Neisseria meningitidis MC58 oxalate/formate antiporter NP_274380.1 1385471 R 122586 CDS NP_274381.1 15677228 903785 complement(1387305..1388660) 1 NC_003112.2 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1388660 xseA 903785 xseA Neisseria meningitidis MC58 exodeoxyribonuclease VII large subunit NP_274381.1 1387305 R 122586 CDS NP_274382.1 15677229 903786 1388857..1389678 1 NC_003112.2 identified by similarity to EGAD:105162; match to protein family HMM PF02540; match to protein family HMM TIGR00552; NH(3)-dependent NAD synthetase 1389678 903786 NMB1364 Neisseria meningitidis MC58 NH(3)-dependent NAD synthetase NP_274382.1 1388857 D 122586 CDS NP_274383.1 15677230 903787 complement(1389748..1390221) 1 NC_003112.2 identified by similarity to EGAD:13856; match to protein family HMM PF03794; hypothetical protein 1390221 903787 NMB1365 Neisseria meningitidis MC58 hypothetical protein NP_274383.1 1389748 R 122586 CDS NP_274384.1 15677231 903788 1390519..1390851 1 NC_003112.2 identified by similarity to EGAD:28738; match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin I 1390851 903788 NMB1366 Neisseria meningitidis MC58 thioredoxin I NP_274384.1 1390519 D 122586 CDS NP_274385.1 15677232 903789 complement(1390904..1391968) 1 NC_003112.2 identified by similarity to EGAD:91631; hypothetical protein 1391968 903789 NMB1367 Neisseria meningitidis MC58 hypothetical protein NP_274385.1 1390904 R 122586 CDS NP_274386.1 15677233 903790 1392179..1393567 1 NC_003112.2 identified by similarity to EGAD:20681; match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 1393567 903790 NMB1368 Neisseria meningitidis MC58 ATP-dependent RNA helicase NP_274386.1 1392179 D 122586 CDS NP_274387.1 15677234 903791 complement(1394056..1394610) 1 NC_003112.2 hypothetical protein 1394610 903791 NMB1369 Neisseria meningitidis MC58 hypothetical protein NP_274387.1 1394056 R 122586 CDS NP_274388.1 15677235 903792 complement(1394695..1395255) 1 NC_003112.2 hypothetical protein 1395255 903792 NMB1370 Neisseria meningitidis MC58 hypothetical protein NP_274388.1 1394695 R 122586 CDS NP_274389.1 15677236 903793 1395599..1396795 1 NC_003112.2 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 1396795 argD 903793 argD Neisseria meningitidis MC58 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase NP_274389.1 1395599 D 122586 CDS NP_274390.1 15677237 903794 complement(1396898..1398142) 1 NC_003112.2 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1398142 clpX 903794 clpX Neisseria meningitidis MC58 ATP-dependent protease ATP-binding subunit ClpX NP_274390.1 1396898 R 122586 CDS NP_274391.1 15677238 903795 1398333..1398704 1 NC_003112.2 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1398704 rbfA 903795 rbfA Neisseria meningitidis MC58 ribosome-binding factor A NP_274391.1 1398333 D 122586 CDS NP_274392.1 15677239 903796 1398737..1399660 1 NC_003112.2 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1399660 truB 903796 truB Neisseria meningitidis MC58 tRNA pseudouridine synthase B NP_274392.1 1398737 D 122586 CDS NP_274393.1 15677240 903799 complement(1404902..1406074) 1 NC_003112.2 identified by similarity to GP:4761135; match to protein family HMM PF01070; L-lactate dehydrogenase 1406074 lldD 903799 lldD Neisseria meningitidis MC58 L-lactate dehydrogenase NP_274393.1 1404902 R 122586 CDS NP_274394.1 15677241 903800 1406365..1406811 1 NC_003112.2 identified by similarity to EGAD:29015; match to protein family HMM PF02082; match to protein family HMM TIGR00738; match to protein family HMM TIGR02010; hypothetical protein 1406811 903800 NMB1378 Neisseria meningitidis MC58 hypothetical protein NP_274394.1 1406365 D 122586 CDS NP_274395.1 15677242 903801 1406840..1408054 1 NC_003112.2 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 1408054 nifS 903801 nifS Neisseria meningitidis MC58 cysteine desulfurase NP_274395.1 1406840 D 122586 CDS NP_274396.1 15677243 903802 1408318..1408704 1 NC_003112.2 identified by similarity to EGAD:90661; match to protein family HMM PF01592; match to protein family HMM TIGR01999; scaffold protein 1408704 903802 NMB1380 Neisseria meningitidis MC58 scaffold protein NP_274396.1 1408318 D 122586 CDS NP_274397.1 15677244 903803 1408731..1409111 1 NC_003112.2 identified by similarity to EGAD:91885; match to protein family HMM PF01521; match to protein family HMM TIGR00049; match to protein family HMM TIGR02011; HesB/YadR/YfhF family protein 1409111 903803 NMB1381 Neisseria meningitidis MC58 HesB/YadR/YfhF family protein NP_274397.1 1408731 D 122586 CDS NP_274398.1 15677245 903804 complement(1409071..1409292) 1 NC_003112.2 identified by similarity to EGAD:21493; match to protein family HMM PF03889; hypothetical protein 1409292 903804 NMB1382 Neisseria meningitidis MC58 hypothetical protein NP_274398.1 1409071 R 122586 CDS NP_274399.1 15677246 903805 1409374..1409874 1 NC_003112.2 identified by similarity to EGAD:6265; match to protein family HMM PF00226; match to protein family HMM PF07743; match to protein family HMM TIGR00714; chaperone protein HscB 1409874 hscB 903805 hscB Neisseria meningitidis MC58 chaperone protein HscB NP_274399.1 1409374 D 122586 CDS NP_274400.1 15677247 903806 1409972..1412722 1 NC_003112.2 identified by similarity to EGAD:21888; match to protein family HMM PF00521; match to protein family HMM PF03989; match to protein family HMM TIGR01063; DNA gyrase subunit A 1412722 gyrA 903806 gyrA Neisseria meningitidis MC58 DNA gyrase subunit A NP_274400.1 1409972 D 122586 CDS YP_338293.1 77358698 903808 1413341..1413796 1 NC_003112.2 identified by similarity to GP:4200438; transposase 1413796 903808 NMB1386 Neisseria meningitidis MC58 transposase YP_338293.1 1413341 D 122586 CDS NP_274401.1 15677248 903809 complement(1414327..1414878) 1 NC_003112.2 hypothetical protein 1414878 903809 NMB1387 Neisseria meningitidis MC58 hypothetical protein NP_274401.1 1414327 R 122586 CDS NP_274402.1 15677249 903810 complement(1414892..1416538) 1 NC_003112.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1416538 pgi 903810 pgi Neisseria meningitidis MC58 glucose-6-phosphate isomerase NP_274402.1 1414892 R 122586 CDS NP_274403.1 15677250 903811 complement(1416659..1417507) 1 NC_003112.2 identified by similarity to EGAD:30099; match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR/YebK/YfhH family protein 1417507 903811 NMB1389 Neisseria meningitidis MC58 RpiR/YebK/YfhH family protein NP_274403.1 1416659 R 122586 CDS NP_274404.1 15677251 903812 complement(1417557..1418543) 1 NC_003112.2 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 1418543 glk 903812 glk Neisseria meningitidis MC58 glucokinase NP_274404.1 1417557 R 122586 CDS NP_274405.1 15677252 903813 complement(1418524..1419219) 1 NC_003112.2 identified by similarity to EGAD:90181; match to protein family HMM TIGR01198; Sol/DevB family oxidoreductase 1419219 903813 NMB1391 Neisseria meningitidis MC58 Sol/DevB family oxidoreductase NP_274405.1 1418524 R 122586 CDS NP_274406.1 15677253 903814 complement(1419499..1420944) 1 NC_003112.2 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1420944 zwf 903814 zwf Neisseria meningitidis MC58 glucose-6-phosphate 1-dehydrogenase NP_274406.1 1419499 R 122586 CDS NP_274407.1 15677254 903815 1421512..1423347 1 NC_003112.2 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1423347 edd 903815 edd Neisseria meningitidis MC58 phosphogluconate dehydratase NP_274407.1 1421512 D 122586 CDS NP_274408.1 15677255 903816 1423528..1424166 1 NC_003112.2 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1424166 eda 903816 eda Neisseria meningitidis MC58 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_274408.1 1423528 D 122586 CDS NP_274409.1 15677256 903817 complement(1424425..1425465) 1 NC_003112.2 identified by similarity to EGAD:21839; match to protein family HMM PF00107; alcohol dehydrogenase 1425465 903817 NMB1395 Neisseria meningitidis MC58 alcohol dehydrogenase NP_274409.1 1424425 R 122586 CDS NP_274410.1 15677257 903818 1425619..1426668 1 NC_003112.2 identified by similarity to GP:3860539; match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase 1426668 mutY 903818 mutY Neisseria meningitidis MC58 A/G-specific adenine glycosylase NP_274410.1 1425619 D 122586 CDS NP_274411.1 15677258 903819 1426831..1427013 1 NC_003112.2 hypothetical protein 1427013 903819 NMB1397 Neisseria meningitidis MC58 hypothetical protein NP_274411.1 1426831 D 122586 CDS NP_274412.1 15677259 903820 1427085..1427645 1 NC_003112.2 identified by similarity to GP:2661420; match to protein family HMM PF00080; superoxide dismutase 1427645 sodC 903820 sodC Neisseria meningitidis MC58 superoxide dismutase NP_274412.1 1427085 D 122586 CDS NP_274413.1 15677260 903821 complement(1428210..1429184) 1 NC_003112.2 identified by similarity to EGAD:5595; match to protein family HMM PF01609; IS1106 transposase 1429184 903821 NMB1399 Neisseria meningitidis MC58 IS1106 transposase NP_274413.1 1428210 R 122586 CDS NP_274414.1 15677261 903822 complement(1429441..1431669) 1 NC_003112.2 identified by similarity to GP:505571; match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01846; ABC transporter family protein 1431669 903822 NMB1400 Neisseria meningitidis MC58 ABC transporter family protein NP_274414.1 1429441 R 122586 CDS NP_274416.1 15677263 903824 1433358..1433792 1 NC_003112.2 hypothetical protein 1433792 903824 NMB1402 Neisseria meningitidis MC58 hypothetical protein NP_274416.1 1433358 D 122586 CDS NP_274417.1 15677264 903825 1433833..1434024 1 NC_003112.2 identified by similarity to EGAD:22554; FrpA/C-like protein 1434024 903825 NMB1403 Neisseria meningitidis MC58 FrpA/C-like protein NP_274417.1 1433833 D 122586 CDS NP_274418.1 15677265 903826 1434059..1434787 1 NC_003112.2 hypothetical protein 1434787 903826 NMB1404 Neisseria meningitidis MC58 hypothetical protein NP_274418.1 1434059 D 122586 CDS NP_274419.1 15677266 903827 1434801..1436003 1 NC_003112.2 identified by similarity to EGAD:22554; FrpA/C-like protein 1436003 903827 NMB1405 Neisseria meningitidis MC58 FrpA/C-like protein NP_274419.1 1434801 D 122586 CDS NP_274423.1 15677270 903832 1439285..1439824 1 NC_003112.2 hypothetical protein 1439824 903832 NMB1410 Neisseria meningitidis MC58 hypothetical protein NP_274423.1 1439285 D 122586 CDS NP_274424.1 15677271 903833 complement(1439995..1440648) 1 NC_003112.2 identified by similarity to EGAD:16254; IS1016C2 transposase 1440648 903833 NMB1411 Neisseria meningitidis MC58 IS1016C2 transposase NP_274424.1 1439995 R 122586 CDS NP_274425.1 15677272 903834 1441254..1442063 1 NC_003112.2 identified by similarity to EGAD:20116; match to protein family HMM PF06901; FrpC operon protein 1442063 903834 NMB1412 Neisseria meningitidis MC58 FrpC operon protein NP_274425.1 1441254 D 122586 CDS NP_274426.1 15677273 903836 1442836..1443609 1 NC_003112.2 identified by similarity to EGAD:20116; match to protein family HMM PF06901; FrpC operon protein 1443609 903836 NMB1414 Neisseria meningitidis MC58 FrpC operon protein NP_274426.1 1442836 D 122586 CDS NP_274427.1 15677274 903837 1443626..1449115 1 NC_003112.2 identified by similarity to EGAD:18289; match to protein family HMM PF00353; iron-regulated protein FrpC 1449115 frpC 903837 frpC Neisseria meningitidis MC58 iron-regulated protein FrpC NP_274427.1 1443626 D 122586 CDS NP_274428.1 15677275 903838 complement(1449457..1452060) 1 NC_003112.2 identified by similarity to EGAD:22470; match to protein family HMM PF01433; match to protein family HMM TIGR02414; aminopeptidase 1452060 pepN 903838 pepN Neisseria meningitidis MC58 aminopeptidase NP_274428.1 1449457 R 122586 CDS NP_274429.1 15677276 903839 complement(1452191..1452985) 1 NC_003112.2 identified by similarity to EGAD:89374; hypothetical protein 1452985 903839 NMB1417 Neisseria meningitidis MC58 hypothetical protein NP_274429.1 1452191 R 122586 CDS NP_274430.1 15677277 903840 complement(1453732..1454601) 1 NC_003112.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1454601 903840 NMB1418 Neisseria meningitidis MC58 lipid A biosynthesis lauroyl acyltransferase NP_274430.1 1453732 R 122586 CDS NP_274431.1 15677278 903841 complement(1454652..1455188) 1 NC_003112.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1455188 ruvC 903841 ruvC Neisseria meningitidis MC58 Holliday junction resolvase NP_274431.1 1454652 R 122586 CDS NP_274432.1 15677279 903842 complement(1455191..1455430) 1 NC_003112.2 identified by similarity to GP:2773326; match to protein family HMM PF02954; match to protein family HMM TIGR01199; DNA-binding protein Fis 1455430 903842 NMB1420 Neisseria meningitidis MC58 DNA-binding protein Fis NP_274432.1 1455191 R 122586 CDS NP_274433.1 15677280 903843 complement(1455460..1456470) 1 NC_003112.2 identified by similarity to EGAD:19890; match to protein family HMM PF01207; match to protein family HMM TIGR00737; nifR3 protein 1456470 903843 NMB1421 Neisseria meningitidis MC58 nifR3 protein NP_274433.1 1455460 R 122586 CDS NP_274434.1 15677281 903844 1456836..1458209 1 NC_003112.2 identified by similarity to GP:4104820; match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 1458209 903844 NMB1422 Neisseria meningitidis MC58 ATP-dependent RNA helicase NP_274434.1 1456836 D 122586 CDS NP_274435.1 15677282 903845 1458784..1459911 1 NC_003112.2 identified by similarity to EGAD:156656; match to protein family HMM PF02661; hypothetical protein 1459911 903845 NMB1423 Neisseria meningitidis MC58 hypothetical protein NP_274435.1 1458784 D 122586 CDS NP_274436.1 15677283 903846 1459941..1460969 1 NC_003112.2 hypothetical protein 1460969 903846 NMB1424 Neisseria meningitidis MC58 hypothetical protein NP_274436.1 1459941 D 122586 CDS NP_274437.1 15677284 903847 complement(1461087..1462598) 1 NC_003112.2 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 1462598 lysS 903847 lysS Neisseria meningitidis MC58 lysyl-tRNA synthetase NP_274437.1 1461087 R 122586 CDS NP_274438.1 15677285 903848 complement(1462753..1464006) 1 NC_003112.2 hypothetical protein 1464006 903848 NMB1426 Neisseria meningitidis MC58 hypothetical protein NP_274438.1 1462753 R 122586 CDS NP_274439.1 15677286 903849 complement(1464067..1464246) 1 NC_003112.2 hypothetical protein 1464246 903849 NMB1427 Neisseria meningitidis MC58 hypothetical protein NP_274439.1 1464067 R 122586 CDS NP_274440.1 15677287 903850 1464464..1466260 1 NC_003112.2 identified by similarity to GP:2760920; match to protein family HMM PF00557; aminopeptidase 1466260 903850 NMB1428 Neisseria meningitidis MC58 aminopeptidase NP_274440.1 1464464 D 122586 CDS NP_274441.1 15677288 903851 complement(1467069..1468247) 1 NC_003112.2 identified by similarity to GP:45187; match to protein family HMM PF00267; outer membrane protein PorA 1468247 porA 903851 porA Neisseria meningitidis MC58 outer membrane protein PorA NP_274441.1 1467069 R 122586 CDS NP_274442.1 15677289 903852 complement(1470526..1471002) 1 NC_003112.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1471002 greA 903852 greA Neisseria meningitidis MC58 transcription elongation factor GreA NP_274442.1 1470526 R 122586 CDS NP_274444.1 15677291 903854 1471398..1472699 1 NC_003112.2 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1472699 aroA 903854 aroA Neisseria meningitidis MC58 3-phosphoshikimate 1-carboxyvinyltransferase NP_274444.1 1471398 D 122586 CDS NP_274445.1 15678009 903133 complement(1472742..1473275) 1 NC_003112.2 identified by similarity to EGAD:37581; match to protein family HMM PF00877; hypothetical protein 1473275 903133 NMB1433 Neisseria meningitidis MC58 hypothetical protein NP_274445.1 1472742 R 122586 CDS NP_274446.1 15677292 903855 complement(1473483..1475009) 1 NC_003112.2 identified by similarity to EGAD:90768; match to protein family HMM PF00614; phopholipase D-family protein 1475009 903855 NMB1434 Neisseria meningitidis MC58 phopholipase D-family protein NP_274446.1 1473483 R 122586 CDS NP_274447.1 15677293 903856 complement(1475121..1476527) 1 NC_003112.2 identified by similarity to EGAD:20464; match to protein family HMM PF07690; drug resistance translocase 1476527 903856 NMB1435 Neisseria meningitidis MC58 drug resistance translocase NP_274447.1 1475121 R 122586 CDS NP_274448.1 15677294 903857 1476812..1477591 1 NC_003112.2 identified by similarity to EGAD:89510; match to protein family HMM PF02754; hypothetical protein 1477591 903857 NMB1436 Neisseria meningitidis MC58 hypothetical protein NP_274448.1 1476812 D 122586 CDS NP_274449.1 15677295 903858 1477588..1478289 1 NC_003112.2 identified by similarity to EGAD:89507; match to protein family HMM PF02589; hypothetical protein 1478289 903858 NMB1437 Neisseria meningitidis MC58 hypothetical protein NP_274449.1 1477588 D 122586 CDS NP_274450.1 15677296 903859 1478286..1479740 1 NC_003112.2 identified by similarity to EGAD:89509; match to protein family HMM PF00037; match to protein family HMM TIGR00273; hypothetical protein 1479740 903859 NMB1438 Neisseria meningitidis MC58 hypothetical protein NP_274450.1 1478286 D 122586 CDS NP_274451.1 15677297 903860 complement(1479923..1480408) 1 NC_003112.2 identified by similarity to EGAD:19627; match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase catalytic subunit 1480408 purE 903860 purE Neisseria meningitidis MC58 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_274451.1 1479923 R 122586 CDS NP_274452.1 15677298 903861 complement(1480456..1481169) 1 NC_003112.2 hypothetical protein 1481169 903861 NMB1440 Neisseria meningitidis MC58 hypothetical protein NP_274452.1 1480456 R 122586 CDS NP_274453.1 15677299 903862 complement(1481169..1481837) 1 NC_003112.2 identified by similarity to EGAD:48809; match to protein family HMM PF01596; O-methyltransferase 1481837 903862 NMB1441 Neisseria meningitidis MC58 O-methyltransferase NP_274453.1 1481169 R 122586 CDS YP_008920715.1 566328929 17925337 complement(1481848..1482033) 1 NC_003112.2 hypothetical protein 1482033 17925337 NMB1441a Neisseria meningitidis MC58 hypothetical protein YP_008920715.1 1481848 R 122586 CDS NP_274454.1 15677300 903863 1482177..1484153 1 NC_003112.2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1484153 mutL 903863 mutL Neisseria meningitidis MC58 DNA mismatch repair protein NP_274454.1 1482177 D 122586 CDS NP_274455.1 15678010 903132 1484248..1486362 1 NC_003112.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1486362 dnaX 903132 dnaX Neisseria meningitidis MC58 DNA polymerase III subunits gamma and tau NP_274455.1 1484248 D 122586 CDS NP_274456.1 15677301 903864 1486442..1486777 1 NC_003112.2 identified by similarity to EGAD:14782; match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 1486777 903864 NMB1444 Neisseria meningitidis MC58 hypothetical protein NP_274456.1 1486442 D 122586 CDS NP_274457.1 15677302 903865 complement(1488548..1489594) 1 NC_003112.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1489594 recA 903865 recA Neisseria meningitidis MC58 recombinase A NP_274457.1 1488548 R 122586 CDS NP_274458.1 15677303 903866 1489848..1490612 1 NC_003112.2 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1490612 aroD 903866 aroD Neisseria meningitidis MC58 3-dehydroquinate dehydratase NP_274458.1 1489848 D 122586 CDS NP_274459.1 15677304 903867 1490632..1492647 1 NC_003112.2 identified by similarity to EGAD:29271; match to protein family HMM PF00580; match to protein family HMM TIGR01074; ATP-dependent DNA helicase 1492647 rep 903867 rep Neisseria meningitidis MC58 ATP-dependent DNA helicase NP_274459.1 1490632 D 122586 CDS NP_274460.1 15677305 903868 complement(1492816..1493772) 1 NC_003112.2 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1493772 dinP 903868 dinP Neisseria meningitidis MC58 DNA polymerase IV NP_274460.1 1492816 R 122586 CDS NP_274461.1 15677306 903870 1497279..1498058 1 NC_003112.2 identified by similarity to EGAD:21243; match to protein family HMM PF00175; ferredoxin--NADP reductase 1498058 fpr-2 903870 fpr-2 Neisseria meningitidis MC58 ferredoxin--NADP reductase NP_274461.1 1497279 D 122586 CDS NP_274462.1 15677307 903871 complement(1498269..1499681) 1 NC_003112.2 identified by similarity to EGAD:157346; match to protein family HMM PF00929; match to protein family HMM TIGR00573; DNA polymerase III subunit epsilon 1499681 dnaQ-1 903871 dnaQ-1 Neisseria meningitidis MC58 DNA polymerase III subunit epsilon NP_274462.1 1498269 R 122586 CDS NP_274463.1 15677308 903874 1500497..1501636 1 NC_003112.2 identified by similarity to EGAD:90034; hypothetical protein 1501636 903874 NMB1452 Neisseria meningitidis MC58 hypothetical protein NP_274463.1 1500497 D 122586 CDS NP_274464.1 15677309 903875 complement(1501882..1502373) 1 NC_003112.2 hypothetical protein 1502373 903875 NMB1453 Neisseria meningitidis MC58 hypothetical protein NP_274464.1 1501882 R 122586 CDS NP_274465.1 15677310 903876 complement(1502433..1503929) 1 NC_003112.2 identified by similarity to EGAD:40049; match to protein family HMM PF00037; ferredoxin, 4Fe-4S type 1503929 903876 NMB1454 Neisseria meningitidis MC58 ferredoxin, 4Fe-4S type NP_274465.1 1502433 R 122586 CDS NP_274466.1 15677311 903877 complement(1503994..1504113) 1 NC_003112.2 hypothetical protein 1504113 903877 NMB1455 Neisseria meningitidis MC58 hypothetical protein NP_274466.1 1503994 R 122586 CDS NP_274468.1 15677313 903879 1504457..1506436 1 NC_003112.2 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1506436 tktA 903879 tktA Neisseria meningitidis MC58 transketolase NP_274468.1 1504457 D 122586 CDS NP_274469.1 15677314 903880 1506585..1507973 1 NC_003112.2 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1507973 fumC 903880 fumC Neisseria meningitidis MC58 fumarate hydratase NP_274469.1 1506585 D 122586 CDS NP_274470.1 15677315 903881 complement(1508038..1508961) 1 NC_003112.2 identified by similarity to EGAD:133404; match to protein family HMM PF00892; hypothetical protein 1508961 903881 NMB1459 Neisseria meningitidis MC58 hypothetical protein NP_274470.1 1508038 R 122586 CDS NP_274471.1 15677316 903882 complement(1509486..1510010) 1 NC_003112.2 identified by similarity to GP:1490785; match to protein family HMM PF00436; match to protein family HMM TIGR00621; ssDNA-binding protein 1510010 ssb 903882 ssb Neisseria meningitidis MC58 ssDNA-binding protein NP_274471.1 1509486 R 122586 CDS NP_274472.1 15677317 903883 complement(1510014..1511399) 1 NC_003112.2 identified by similarity to EGAD:91169; match to protein family HMM PF07690; drug resistance translocase 1511399 903883 NMB1461 Neisseria meningitidis MC58 drug resistance translocase NP_274472.1 1510014 R 122586 CDS NP_274473.1 15677318 903884 complement(1511507..1512130) 1 NC_003112.2 identified by similarity to EGAD:107330; match to protein family HMM PF01464; transglycosylase 1512130 903884 NMB1462 Neisseria meningitidis MC58 transglycosylase NP_274473.1 1511507 R 122586 CDS NP_274474.1 15677319 903886 complement(1513088..1513579) 1 NC_003112.2 identified by similarity to EGAD:37582; match to protein family HMM PF07605; hypothetical protein 1513579 903886 NMB1464 Neisseria meningitidis MC58 hypothetical protein NP_274474.1 1513088 R 122586 CDS YP_008920716.1 566328930 903887 complement(1514518..1515210) 1 NC_003112.2 hypothetical protein 1515210 903887 NMB1465 Neisseria meningitidis MC58 hypothetical protein YP_008920716.1 1514518 R 122586 CDS NP_274475.1 15677320 903888 1515677..1516408 1 NC_003112.2 identified by similarity to EGAD:28010; match to protein family HMM PF04575; hypothetical protein 1516408 903888 NMB1466 Neisseria meningitidis MC58 hypothetical protein NP_274475.1 1515677 D 122586 CDS NP_274476.1 15677321 903889 1516525..1518033 1 NC_003112.2 identified by similarity to GP:3452466; match to protein family HMM PF02541; exopolyphosphatase 1518033 ppx 903889 ppx Neisseria meningitidis MC58 exopolyphosphatase NP_274476.1 1516525 D 122586 CDS NP_274477.1 15677322 903890 complement(1518242..1518565) 1 NC_003112.2 hypothetical protein 1518565 903890 NMB1468 Neisseria meningitidis MC58 hypothetical protein NP_274477.1 1518242 R 122586 CDS NP_274478.1 15677323 903891 complement(1518562..1518645) 1 NC_003112.2 hypothetical protein 1518645 903891 NMB1469 Neisseria meningitidis MC58 hypothetical protein NP_274478.1 1518562 R 122586 CDS NP_274479.1 15677324 903892 complement(1518885..1519430) 1 NC_003112.2 hypothetical protein 1519430 903892 NMB1470 Neisseria meningitidis MC58 hypothetical protein NP_274479.1 1518885 R 122586 CDS NP_274480.1 15677325 903893 complement(1519499..1520509) 1 NC_003112.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1520509 trpS 903893 trpS Neisseria meningitidis MC58 tryptophanyl-tRNA synthetase NP_274480.1 1519499 R 122586 CDS NP_274481.1 15677326 903894 1520770..1523349 1 NC_003112.2 identified by similarity to EGAD:20010; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; clpB protein 1523349 clpB 903894 clpB Neisseria meningitidis MC58 clpB protein NP_274481.1 1520770 D 122586 CDS NP_274482.1 15677327 903895 complement(1523436..1524650) 1 NC_003112.2 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 1524650 903895 NMB1473 Neisseria meningitidis MC58 aminotransferase NP_274482.1 1523436 R 122586 CDS NP_274483.1 15677328 903896 complement(1524739..1524948) 1 NC_003112.2 identified by similarity to EGAD:19065; match to protein family HMM PF01361; match to protein family HMM TIGR00013; 4-oxalocrotonate tautomerase 1524948 903896 NMB1474 Neisseria meningitidis MC58 4-oxalocrotonate tautomerase NP_274483.1 1524739 R 122586 CDS NP_274484.1 15677329 903897 1525293..1526099 1 NC_003112.2 identified by similarity to EGAD:28416; hypothetical protein 1526099 903897 NMB1475 Neisseria meningitidis MC58 hypothetical protein NP_274484.1 1525293 D 122586 CDS NP_274485.1 15677330 903898 complement(1526157..1527422) 1 NC_003112.2 identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; glutamate dehydrogenase 1527422 gluD 903898 gluD Neisseria meningitidis MC58 glutamate dehydrogenase NP_274485.1 1526157 R 122586 CDS NP_274486.1 15677331 903899 complement(1527415..1527600) 1 NC_003112.2 hypothetical protein 1527600 903899 NMB1477 Neisseria meningitidis MC58 hypothetical protein NP_274486.1 1527415 R 122586 CDS NP_274487.1 15677332 903901 1528598..1529059 1 NC_003112.2 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1529059 recX 903901 recX Neisseria meningitidis MC58 recombination regulator RecX NP_274487.1 1528598 D 122586 CDS NP_274489.1 15677334 903903 1529300..1529434 1 NC_003112.2 hypothetical protein 1529434 903903 NMB1481 Neisseria meningitidis MC58 hypothetical protein NP_274489.1 1529300 D 122586 CDS NP_274490.1 15677335 903904 1529447..1529929 1 NC_003112.2 identified by similarity to EGAD:167992; match to protein family HMM PF03061; acyl CoA thioester hydrolase 1529929 903904 NMB1482 Neisseria meningitidis MC58 acyl CoA thioester hydrolase NP_274490.1 1529447 D 122586 CDS NP_274491.1 15677336 903905 complement(1530290..1531537) 1 NC_003112.2 identified by similarity to EGAD:20336; match to protein family HMM PF01476; match to protein family HMM PF01551; lipoprotein NlpD 1531537 903905 NMB1483 Neisseria meningitidis MC58 lipoprotein NlpD NP_274491.1 1530290 R 122586 CDS NP_274492.1 15677337 903906 complement(1531793..1532539) 1 NC_003112.2 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1532539 surE 903906 surE Neisseria meningitidis MC58 stationary phase survival protein SurE NP_274492.1 1531793 R 122586 CDS NP_274493.1 15677338 903907 complement(1532556..1534112) 1 NC_003112.2 identified by similarity to EGAD:91225; match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741; hypothetical protein 1534112 903907 NMB1485 Neisseria meningitidis MC58 hypothetical protein NP_274493.1 1532556 R 122586 CDS NP_274494.1 15677339 903908 complement(1534161..1534301) 1 NC_003112.2 hypothetical protein 1534301 903908 NMB1486 Neisseria meningitidis MC58 hypothetical protein NP_274494.1 1534161 R 122586 CDS NP_274495.1 15677340 903909 complement(1534480..1535268) 1 NC_003112.2 identified by similarity to EGAD:8572; fimbrial assembly protein 1535268 fimB 903909 fimB Neisseria meningitidis MC58 fimbrial assembly protein NP_274495.1 1534480 R 122586 CDS NP_274496.1 15677341 903910 complement(1535377..1536810) 1 NC_003112.2 identified by similarity to EGAD:16804; match to protein family HMM PF00171; match to protein family HMM TIGR01780; succinate semialdehyde dehydrogenase 1536810 gabD 903910 gabD Neisseria meningitidis MC58 succinate semialdehyde dehydrogenase NP_274496.1 1535377 R 122586 CDS NP_274497.1 15677342 903911 1537297..1537791 1 NC_003112.2 hypothetical protein 1537791 903911 NMB1489 Neisseria meningitidis MC58 hypothetical protein NP_274497.1 1537297 D 122586 CDS NP_274499.1 15677344 903913 complement(1538734..1538823) 1 NC_003112.2 hypothetical protein 1538823 903913 NMB1491 Neisseria meningitidis MC58 hypothetical protein NP_274499.1 1538734 R 122586 CDS NP_274500.1 15677345 903914 complement(1538830..1538898) 1 NC_003112.2 hypothetical protein 1538898 903914 NMB1492 Neisseria meningitidis MC58 hypothetical protein NP_274500.1 1538830 R 122586 CDS NP_274501.1 15677346 903915 1538930..1541011 1 NC_003112.2 identified by similarity to EGAD:8578; match to protein family HMM PF02554; carbon starvation protein A 1541011 cstA 903915 cstA Neisseria meningitidis MC58 carbon starvation protein A NP_274501.1 1538930 D 122586 CDS NP_274502.1 15677347 903916 1541001..1541195 1 NC_003112.2 identified by similarity to EGAD:6530; match to protein family HMM PF04328; hypothetical protein 1541195 903916 NMB1494 Neisseria meningitidis MC58 hypothetical protein NP_274502.1 1541001 D 122586 CDS NP_274503.1 15677348 903917 1541409..1541603 1 NC_003112.2 hypothetical protein 1541603 903917 NMB1495 Neisseria meningitidis MC58 hypothetical protein NP_274503.1 1541409 D 122586 CDS NP_274504.1 15677349 903918 1541711..1542271 1 NC_003112.2 identified by similarity to EGAD:91124; match to protein family HMM PF00849; match to protein family HMM TIGR00093; hypothetical protein 1542271 903918 NMB1496 Neisseria meningitidis MC58 hypothetical protein NP_274504.1 1541711 D 122586 CDS NP_274505.1 15677350 903921 1543272..1546037 1 NC_003112.2 identified by similarity to EGAD:28219; match to protein family HMM PF00593; match to protein family HMM PF07715; TonB-dependent receptor 1546037 903921 NMB1497 Neisseria meningitidis MC58 TonB-dependent receptor NP_274505.1 1543272 D 122586 CDS NP_274506.1 15677351 903923 complement(1548041..1549258) 1 NC_003112.2 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1549258 lysC 903923 lysC Neisseria meningitidis MC58 aspartate kinase NP_274506.1 1548041 R 122586 CDS NP_274507.1 15677352 903925 complement(1549458..1550186) 1 NC_003112.2 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1550186 rph 903925 rph Neisseria meningitidis MC58 ribonuclease PH NP_274507.1 1549458 R 122586 CDS NP_274508.1 15677353 903931 complement(1550268..1550732) 1 NC_003112.2 identified by similarity to EGAD:105670; match to protein family HMM PF00582; hypothetical protein 1550732 903931 NMB1500 Neisseria meningitidis MC58 hypothetical protein NP_274508.1 1550268 R 122586 CDS NP_274509.1 15677354 903934 1550949..1551725 1 NC_003112.2 identified by similarity to EGAD:21693; match to protein family HMM PF00899; HesA/MoeB/ThiF family protein 1551725 903934 NMB1501 Neisseria meningitidis MC58 HesA/MoeB/ThiF family protein NP_274509.1 1550949 D 122586 CDS NP_274510.1 15677355 903936 1551863..1552390 1 NC_003112.2 hypothetical protein 1552390 903936 NMB1502 Neisseria meningitidis MC58 hypothetical protein NP_274510.1 1551863 D 122586 CDS NP_274511.1 15677356 903942 1552646..1552855 1 NC_003112.2 hypothetical protein 1552855 903942 NMB1503 Neisseria meningitidis MC58 hypothetical protein NP_274511.1 1552646 D 122586 CDS NP_274512.1 15677357 903945 1552744..1553598 1 NC_003112.2 identified by similarity to EGAD:14314; match to protein family HMM PF02616; segregation and condensation protein A 1553598 scpA 903945 scpA Neisseria meningitidis MC58 segregation and condensation protein A NP_274512.1 1552744 D 122586 CDS NP_274513.1 15677358 903949 1553639..1554847 1 NC_003112.2 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1554847 pncB 903949 pncB Neisseria meningitidis MC58 nicotinate phosphoribosyltransferase NP_274513.1 1553639 D 122586 CDS NP_274514.1 15677359 903953 1554939..1556657 1 NC_003112.2 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1556657 argS 903953 argS Neisseria meningitidis MC58 arginyl-tRNA synthetase NP_274514.1 1554939 D 122586 CDS NP_274516.1 15677361 903957 1557168..1558625 1 NC_003112.2 hypothetical protein 1558625 903957 NMB1508 Neisseria meningitidis MC58 hypothetical protein NP_274516.1 1557168 D 122586 CDS NP_274517.1 15677362 903968 complement(1559636..1560382) 1 NC_003112.2 identified by similarity to EGAD:103138; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 1560382 903968 NMB1509 Neisseria meningitidis MC58 amino acid ABC transporter permease NP_274517.1 1559636 R 122586 CDS NP_274518.1 15677363 903976 complement(1560561..1561262) 1 NC_003112.2 identified by similarity to EGAD:28294; match to protein family HMM PF00565; thermonuclease 1561262 903976 NMB1510 Neisseria meningitidis MC58 thermonuclease NP_274518.1 1560561 R 122586 CDS NP_274519.1 15677364 903979 complement(1561301..1561972) 1 NC_003112.2 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1561972 rpiA 903979 rpiA Neisseria meningitidis MC58 ribose-5-phosphate isomerase A NP_274519.1 1561301 R 122586 CDS NP_274520.1 15677365 903980 complement(1562049..1562531) 1 NC_003112.2 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1562531 ispF 903980 ispF Neisseria meningitidis MC58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_274520.1 1562049 R 122586 CDS NP_274521.1 15677366 903982 complement(1562563..1563252) 1 NC_003112.2 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1563252 ispD 903982 ispD Neisseria meningitidis MC58 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_274521.1 1562563 R 122586 CDS NP_274522.1 15677367 903984 complement(1563249..1563983) 1 NC_003112.2 identified by similarity to EGAD:21587; match to protein family HMM PF00929; match to protein family HMM TIGR00573; match to protein family HMM TIGR01406; DNA polymerase III subunit epsilon 1563983 dnaQ-2 903984 dnaQ-2 Neisseria meningitidis MC58 DNA polymerase III subunit epsilon NP_274522.1 1563249 R 122586 CDS NP_274523.1 15677368 903986 complement(1564139..1565449) 1 NC_003112.2 identified by similarity to EGAD:36624; match to protein family HMM PF07690; transporter 1565449 903986 NMB1515 Neisseria meningitidis MC58 transporter NP_274523.1 1564139 R 122586 CDS NP_274524.1 15677369 903990 complement(1565439..1565627) 1 NC_003112.2 identified by similarity to GP:2398785; match to protein family HMM PF03597; match to protein family HMM TIGR00847; fixS protein 1565627 fixS 903990 fixS Neisseria meningitidis MC58 fixS protein NP_274524.1 1565439 R 122586 CDS NP_274525.1 15677370 903991 complement(1565624..1565923) 1 NC_003112.2 hypothetical protein 1565923 903991 NMB1517 Neisseria meningitidis MC58 hypothetical protein NP_274525.1 1565624 R 122586 CDS NP_274526.1 15677371 903996 1566274..1567470 1 NC_003112.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1567470 ackA-2 903996 ackA-2 Neisseria meningitidis MC58 acetate kinase NP_274526.1 1566274 D 122586 CDS NP_274527.1 15677372 904002 complement(1567985..1569790) 1 NC_003112.2 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1569790 dipZ 904002 dipZ Neisseria meningitidis MC58 thiol:disulfide interchange protein NP_274527.1 1567985 R 122586 CDS YP_008920717.1 566328931 17925338 1569917..1570387 1 NC_003112.2 hypothetical protein 1570387 17925338 NMB1521a Neisseria meningitidis MC58 hypothetical protein YP_008920717.1 1569917 D 122586 CDS NP_274529.1 15677374 904008 complement(1570460..1571287) 1 NC_003112.2 identified by similarity to GP:2113820; match to protein family HMM PF00494; phytoene synthase 1571287 904008 NMB1521 Neisseria meningitidis MC58 phytoene synthase NP_274529.1 1570460 R 122586 CDS NP_274530.1 15677375 904012 complement(1571359..1571841) 1 NC_003112.2 identified by similarity to EGAD:17346; match to protein family HMM PF00254; FKBP-type peptidylprolyl isomerase 1571841 slyD 904012 slyD Neisseria meningitidis MC58 FKBP-type peptidylprolyl isomerase NP_274530.1 1571359 R 122586 CDS NP_274531.1 15677376 904013 1572314..1572610 1 NC_003112.2 hypothetical protein 1572610 904013 NMB1523 Neisseria meningitidis MC58 hypothetical protein NP_274531.1 1572314 D 122586 CDS NP_274532.1 15677377 904017 1572720..1574087 1 NC_003112.2 identified by similarity to EGAD:51447; match to protein family HMM PF01565; match to protein family HMM PF02913; oxidoreductase 1574087 904017 NMB1524 Neisseria meningitidis MC58 oxidoreductase NP_274532.1 1572720 D 122586 CDS NP_274533.1 15677378 904025 complement(1576673..1577119) 1 NC_003112.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1577119 smpB 904025 smpB Neisseria meningitidis MC58 SsrA-binding protein NP_274533.1 1576673 R 122586 CDS NP_274534.1 15677379 904029 complement(1577174..1578184) 1 NC_003112.2 identified by similarity to EGAD:40767; match to protein family HMM PF01075; match to protein family HMM TIGR02195; ADP-heptose--LPS heptosyltransferase 1578184 rfaF 904029 rfaF Neisseria meningitidis MC58 ADP-heptose--LPS heptosyltransferase NP_274534.1 1577174 R 122586 CDS NP_274535.1 15677380 904039 complement(1578582..1579391) 1 NC_003112.2 identified by similarity to EGAD:15497; match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589; methylated-DNA--protein-cysteine methyltransferase 1579391 904039 NMB1528 Neisseria meningitidis MC58 methylated-DNA--protein-cysteine methyltransferase NP_274535.1 1578582 R 122586 CDS NP_274536.1 15677381 904043 1579635..1580450 1 NC_003112.2 hypothetical protein 1580450 904043 NMB1529 Neisseria meningitidis MC58 hypothetical protein NP_274536.1 1579635 D 122586 CDS NP_274537.1 15677382 904046 complement(1581121..1582266) 1 NC_003112.2 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 1582266 dapE 904046 dapE Neisseria meningitidis MC58 succinyl-diaminopimelate desuccinylase NP_274537.1 1581121 R 122586 CDS NP_274538.1 15677383 904052 complement(1582379..1582999) 1 NC_003112.2 identified by similarity to EGAD:29187; hypothetical protein 1582999 904052 NMB1531 Neisseria meningitidis MC58 hypothetical protein NP_274538.1 1582379 R 122586 CDS NP_274539.1 15677384 904056 complement(1583033..1583542) 1 NC_003112.2 identified by similarity to EGAD:28880; match to protein family HMM PF03794; hypothetical protein 1583542 904056 NMB1532 Neisseria meningitidis MC58 hypothetical protein NP_274539.1 1583033 R 122586 CDS NP_274540.1 15677385 904058 complement(1583637..1584188) 1 NC_003112.2 identified by similarity to EGAD:7135; match to protein family HMM PF00127; outer membrane protein 1584188 904058 NMB1533 Neisseria meningitidis MC58 outer membrane protein NP_274540.1 1583637 R 122586 CDS NP_274541.1 15677386 904062 complement(1584185..1584325) 1 NC_003112.2 hypothetical protein 1584325 904062 NMB1534 Neisseria meningitidis MC58 hypothetical protein NP_274541.1 1584185 R 122586 CDS YP_008920718.1 566328932 17925339 complement(1584469..1584891) 1 NC_003112.2 hypothetical protein 1584891 17925339 NMB1536q Neisseria meningitidis MC58 hypothetical protein YP_008920718.1 1584469 R 122586 CDS NP_274543.1 15677388 904068 1585022..1587772 1 NC_003112.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1587772 secA 904068 secA Neisseria meningitidis MC58 preprotein translocase subunit SecA NP_274543.1 1585022 D 122586 CDS NP_274544.1 15677389 904069 1587917..1589689 1 NC_003112.2 synthesizes RNA primers at the replication forks; DNA primase 1589689 dnaG 904069 dnaG Neisseria meningitidis MC58 DNA primase NP_274544.1 1587917 D 122586 CDS NP_274545.1 15677390 904073 1589876..1591804 1 NC_003112.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1591804 rpoD 904073 rpoD Neisseria meningitidis MC58 RNA polymerase sigma factor RpoD NP_274545.1 1589876 D 122586 CDS NP_274546.1 15677391 904074 1591951..1592958 1 NC_003112.2 identified by similarity to EGAD:5595; match to protein family HMM PF01609; IS1106 transposase 1592958 904074 NMB1539 Neisseria meningitidis MC58 IS1106 transposase NP_274546.1 1591951 D 122586 CDS NP_274547.1 15677392 904077 complement(1594478..1597309) 1 NC_003112.2 identified by similarity to EGAD:40813; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01776; match to protein family HMM TIGR01786; lactoferrin-binding protein A 1597309 lbpA 904077 lbpA Neisseria meningitidis MC58 lactoferrin-binding protein A NP_274547.1 1594478 R 122586 CDS NP_274548.1 15677393 904078 complement(1597306..1599519) 1 NC_003112.2 identified by similarity to GP:3582728; match to protein family HMM PF01298; lactoferrin-binding protein 1599519 lbpB 904078 lbpB Neisseria meningitidis MC58 lactoferrin-binding protein NP_274548.1 1597306 R 122586 CDS NP_274550.1 15677395 904083 1600909..1602123 1 NC_003112.2 identified by similarity to GP:3402495; match to protein family HMM PF02486; hypothetical protein 1602123 904083 NMB1543 Neisseria meningitidis MC58 hypothetical protein NP_274550.1 1600909 D 122586 CDS NP_274551.1 15677396 904085 1602135..1602446 1 NC_003112.2 hypothetical protein 1602446 904085 NMB1544 Neisseria meningitidis MC58 hypothetical protein NP_274551.1 1602135 D 122586 CDS NP_274552.1 15677397 904086 1602450..1602650 1 NC_003112.2 hypothetical protein 1602650 904086 NMB1545 Neisseria meningitidis MC58 hypothetical protein NP_274552.1 1602450 D 122586 CDS NP_274553.1 15677398 904087 1602833..1603117 1 NC_003112.2 hypothetical protein 1603117 904087 NMB1546 Neisseria meningitidis MC58 hypothetical protein NP_274553.1 1602833 D 122586 CDS NP_274554.1 15677399 904091 1603145..1603447 1 NC_003112.2 hypothetical protein 1603447 904091 NMB1547 Neisseria meningitidis MC58 hypothetical protein NP_274554.1 1603145 D 122586 CDS NP_274555.1 15677400 904097 1603779..1605425 1 NC_003112.2 identified by similarity to GP:3758871; match to protein family HMM PF05616; tspB protein 1605425 904097 NMB1548 Neisseria meningitidis MC58 tspB protein NP_274555.1 1603779 D 122586 CDS NP_274557.1 15677402 904099 1606370..1606654 1 NC_003112.2 identified by similarity to EGAD:69712; hypothetical protein 1606654 904099 NMB1550 Neisseria meningitidis MC58 hypothetical protein NP_274557.1 1606370 D 122586 CDS NP_274558.1 15677403 904101 1606655..1607758 1 NC_003112.2 identified by similarity to GP:3402502; match to protein family HMM PF05707; hypothetical protein 1607758 904101 NMB1551 Neisseria meningitidis MC58 hypothetical protein NP_274558.1 1606655 D 122586 CDS NP_274559.1 15677404 904103 1608057..1609013 1 NC_003112.2 identified by similarity to EGAD:138632; match to protein family HMM PF01548; match to protein family HMM PF02371; pilin gene inverting protein PivNM-1A 1609013 pivNM-1A 904103 pivNM-1A Neisseria meningitidis MC58 pilin gene inverting protein PivNM-1A NP_274559.1 1608057 D 122586 CDS NP_274560.1 15678011 903131 complement(1611743..1612060) 1 NC_003112.2 identified by similarity to EGAD:137210; transposase, truncation 1612060 903131 NMB1553 Neisseria meningitidis MC58 transposase, truncation NP_274560.1 1611743 R 122586 CDS NP_274561.1 15677405 904105 complement(1612288..1613922) 1 NC_003112.2 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1613922 pyrG 904105 pyrG Neisseria meningitidis MC58 CTP synthetase NP_274561.1 1612288 R 122586 CDS NP_274562.1 15677406 904112 complement(1614034..1615704) 1 NC_003112.2 identified by similarity to EGAD:141787; match to protein family HMM PF00501; long-chain-fatty-acid--CoA-ligase 1615704 fadD-2 904112 fadD-2 Neisseria meningitidis MC58 long-chain-fatty-acid--CoA-ligase NP_274562.1 1614034 R 122586 CDS NP_274563.1 15677407 904116 complement(1615775..1616878) 1 NC_003112.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1616878 mnmA 904116 mnmA Neisseria meningitidis MC58 tRNA-specific 2-thiouridylase MnmA NP_274563.1 1615775 R 122586 CDS NP_274564.1 15677408 904118 complement(1617004..1617477) 1 NC_003112.2 identified by similarity to EGAD:156049; match to protein family HMM PF04314; hypothetical protein 1617477 904118 NMB1557 Neisseria meningitidis MC58 hypothetical protein NP_274564.1 1617004 R 122586 CDS NP_274565.1 15677409 904121 complement(1617770..1618153) 1 NC_003112.2 identified by similarity to EGAD:13380; match to protein family HMM PF01219; diacylglycerol kinase 1618153 dgkA 904121 dgkA Neisseria meningitidis MC58 diacylglycerol kinase NP_274565.1 1617770 R 122586 CDS NP_274566.1 15677410 904122 complement(1618465..1619424) 1 NC_003112.2 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 1619424 gshB 904122 gshB Neisseria meningitidis MC58 glutathione synthetase NP_274566.1 1618465 R 122586 CDS NP_274567.2 161353783 904126 complement(1619514..1621235) 1 NC_003112.2 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1621235 glnS 904126 glnS Neisseria meningitidis MC58 glutaminyl-tRNA synthetase NP_274567.2 1619514 R 122586 CDS NP_274568.1 15677412 904128 complement(1621314..1622087) 1 NC_003112.2 identified by similarity to EGAD:102141; match to protein family HMM PF00455; DeoR family transcriptional regulator 1622087 904128 NMB1561 Neisseria meningitidis MC58 DeoR family transcriptional regulator NP_274568.1 1621314 R 122586 CDS NP_274569.1 15677413 904132 complement(1622130..1623032) 1 NC_003112.2 identified by similarity to EGAD:91752; match to protein family HMM PF03956; hypothetical protein 1623032 904132 NMB1562 Neisseria meningitidis MC58 hypothetical protein NP_274569.1 1622130 R 122586 CDS NP_274570.1 15677414 904136 complement(1623181..1623897) 1 NC_003112.2 identified by similarity to GP:2661693; match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 1623897 904136 NMB1563 Neisseria meningitidis MC58 GntR family transcriptional regulator NP_274570.1 1623181 R 122586 CDS NP_274571.1 15677415 904138 complement(1624466..1624888) 1 NC_003112.2 identified by similarity to EGAD:91663; match to protein family HMM PF02566; hypothetical protein 1624888 904138 NMB1564 Neisseria meningitidis MC58 hypothetical protein NP_274571.1 1624466 R 122586 CDS NP_274572.1 15677416 904140 complement(1625006..1625677) 1 NC_003112.2 hypothetical protein 1625677 904140 NMB1565 Neisseria meningitidis MC58 hypothetical protein NP_274572.1 1625006 R 122586 CDS NP_274573.1 15677417 904144 complement(1625693..1626319) 1 NC_003112.2 identified by similarity to GP:1562542; match to protein family HMM PF00551; match to protein family HMM TIGR00639; phosphoribosylglycinamide transformylase 1626319 purN 904144 purN Neisseria meningitidis MC58 phosphoribosylglycinamide transformylase NP_274573.1 1625693 R 122586 CDS NP_274574.1 15677418 904149 complement(1626426..1627244) 1 NC_003112.2 identified by similarity to GP:2231726; match to protein family HMM PF00254; match to protein family HMM PF01346; macrophage infectivity potentiator 1627244 904149 NMB1567 Neisseria meningitidis MC58 macrophage infectivity potentiator NP_274574.1 1626426 R 122586 CDS NP_274575.1 15677419 904151 complement(1627503..1627943) 1 NC_003112.2 identified by similarity to GP:2984772; match to protein family HMM PF04364; DNA polymerase III subunit chi 1627943 904151 NMB1568 Neisseria meningitidis MC58 DNA polymerase III subunit chi NP_274575.1 1627503 R 122586 CDS NP_274576.1 15677420 904153 1629582..1630697 1 NC_003112.2 identified by similarity to EGAD:24062; match to protein family HMM PF03739; hypothetical protein 1630697 904153 NMB1570 Neisseria meningitidis MC58 hypothetical protein NP_274576.1 1629582 D 122586 CDS NP_274577.1 15677421 904157 1630694..1631764 1 NC_003112.2 identified by similarity to EGAD:28691; match to protein family HMM PF03739; hypothetical protein 1631764 904157 NMB1571 Neisseria meningitidis MC58 hypothetical protein NP_274577.1 1630694 D 122586 CDS NP_274578.1 15677422 904159 1631974..1634559 1 NC_003112.2 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 1634559 acnB 904159 acnB Neisseria meningitidis MC58 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase NP_274578.1 1631974 D 122586 CDS NP_274579.1 15677423 904168 1634701..1635696 1 NC_003112.2 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1635696 argF 904168 argF Neisseria meningitidis MC58 ornithine carbamoyltransferase NP_274579.1 1634701 D 122586 CDS NP_274580.1 15677424 904172 complement(1635920..1636933) 1 NC_003112.2 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1636933 ilvC 904172 ilvC Neisseria meningitidis MC58 ketol-acid reductoisomerase NP_274580.1 1635920 R 122586 CDS NP_274581.1 15677425 904182 complement(1637013..1637306) 1 NC_003112.2 identified by similarity to EGAD:108978; match to protein family HMM PF03992; hypothetical protein 1637306 904182 NMB1575 Neisseria meningitidis MC58 hypothetical protein NP_274581.1 1637013 R 122586 CDS NP_274582.1 15677426 904183 complement(1637373..1637864) 1 NC_003112.2 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1637864 ilvH 904183 ilvH Neisseria meningitidis MC58 acetolactate synthase 3 regulatory subunit NP_274582.1 1637373 R 122586 CDS NP_274583.1 15677427 904184 complement(1637875..1639602) 1 NC_003112.2 identified by similarity to EGAD:28577; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118; acetolactate synthase isozyme III large subunit 1639602 ilvI 904184 ilvI Neisseria meningitidis MC58 acetolactate synthase isozyme III large subunit NP_274583.1 1637875 R 122586 CDS NP_274584.1 15677428 904204 1640723..1641376 1 NC_003112.2 identified by similarity to EGAD:156017; match to protein family HMM PF02630; hypothetical protein 1641376 904204 NMB1578 Neisseria meningitidis MC58 hypothetical protein NP_274584.1 1640723 D 122586 CDS NP_274585.1 15677429 904212 1641455..1642108 1 NC_003112.2 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase 1642108 hisG 904212 hisG Neisseria meningitidis MC58 ATP phosphoribosyltransferase NP_274585.1 1641455 D 122586 CDS NP_274586.1 15677430 904219 1642212..1643111 1 NC_003112.2 hypothetical protein 1643111 904219 NMB1580 Neisseria meningitidis MC58 hypothetical protein NP_274586.1 1642212 D 122586 CDS NP_274587.1 15677431 904220 1643108..1644397 1 NC_003112.2 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1644397 hisD 904220 hisD Neisseria meningitidis MC58 histidinol dehydrogenase NP_274587.1 1643108 D 122586 CDS NP_274588.1 15677432 904223 1644443..1645540 1 NC_003112.2 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1645540 hisC 904223 hisC Neisseria meningitidis MC58 histidinol-phosphate aminotransferase NP_274588.1 1644443 D 122586 CDS NP_274589.2 161353782 904235 1645720..1646454 1 NC_003112.2 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1646454 hisB 904235 hisB Neisseria meningitidis MC58 imidazoleglycerol-phosphate dehydratase NP_274589.2 1645720 D 122586 CDS NP_274590.1 15677434 904236 1646549..1647418 1 NC_003112.2 identified by similarity to EGAD:155484; match to protein family HMM PF03446; 3-hydroxyacid dehydrogenase 1647418 904236 NMB1584 Neisseria meningitidis MC58 3-hydroxyacid dehydrogenase NP_274590.1 1646549 D 122586 CDS NP_274591.1 15677435 904237 1647696..1648127 1 NC_003112.2 identified by similarity to GP:2791909; match to protein family HMM PF01047; MarR family transcriptional regulator 1648127 904237 NMB1585 Neisseria meningitidis MC58 MarR family transcriptional regulator NP_274591.1 1647696 D 122586 CDS NP_274592.1 15677436 904238 1648138..1649004 1 NC_003112.2 hypothetical protein 1649004 904238 NMB1586 Neisseria meningitidis MC58 hypothetical protein NP_274592.1 1648138 D 122586 CDS NP_274593.1 15677437 904239 complement(1649055..1650158) 1 NC_003112.2 SohB; periplasmic protein; member of the peptidase S49 family; protease 1650158 904239 NMB1587 Neisseria meningitidis MC58 protease NP_274593.1 1649055 R 122586 CDS NP_274594.1 15677438 904259 complement(1650954..1651517) 1 NC_003112.2 identified by similarity to EGAD:19485; match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1651517 pgsA 904259 pgsA Neisseria meningitidis MC58 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_274594.1 1650954 R 122586 CDS NP_274596.1 15677440 904263 complement(1652378..1652713) 1 NC_003112.2 identified by similarity to EGAD:28075; match to protein family HMM PF02627; match to protein family HMM TIGR00778; hypothetical protein 1652713 904263 NMB1590 Neisseria meningitidis MC58 hypothetical protein NP_274596.1 1652378 R 122586 CDS NP_274597.1 15677441 904265 1652842..1653747 1 NC_003112.2 identified by similarity to EGAD:28074; match to protein family HMM PF00165; AraC family transcriptional regulator 1653747 mtrA 904265 mtrA Neisseria meningitidis MC58 AraC family transcriptional regulator NP_274597.1 1652842 D 122586 CDS NP_274598.2 77358706 904266 complement(1653809..1654297) 1 NC_003112.2 lipoprotein 1654297 904266 NMB1592 Neisseria meningitidis MC58 lipoprotein NP_274598.2 1653809 R 122586 CDS NP_274599.1 15677443 904269 1654483..1655346 1 NC_003112.2 identified by similarity to EGAD:157019; match to protein family HMM PF00892; hypothetical protein 1655346 904269 NMB1593 Neisseria meningitidis MC58 hypothetical protein NP_274599.1 1654483 D 122586 CDS NP_274600.1 15677444 904275 complement(1655387..1656517) 1 NC_003112.2 identified by similarity to EGAD:16715; match to protein family HMM PF01547; spermidine/putrescine ABC transporter substrate-binding protein 1656517 potD-3 904275 potD-3 Neisseria meningitidis MC58 spermidine/putrescine ABC transporter substrate-binding protein NP_274600.1 1655387 R 122586 CDS NP_274601.1 15677445 904276 1656722..1659346 1 NC_003112.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1659346 alaS 904276 alaS Neisseria meningitidis MC58 alanyl-tRNA synthetase NP_274601.1 1656722 D 122586 CDS NP_274603.1 15677447 904278 1659607..1660038 1 NC_003112.2 hypothetical protein 1660038 904278 NMB1597 Neisseria meningitidis MC58 hypothetical protein NP_274603.1 1659607 D 122586 CDS NP_274604.1 15677448 904279 1660132..1660323 1 NC_003112.2 hypothetical protein 1660323 904279 NMB1598 Neisseria meningitidis MC58 hypothetical protein NP_274604.1 1660132 D 122586 CDS NP_274606.1 15677450 904282 1660662..1660919 1 NC_003112.2 hypothetical protein 1660919 904282 NMB1600 Neisseria meningitidis MC58 hypothetical protein NP_274606.1 1660662 D 122586 CDS NP_274607.1 15677451 904284 1661113..1662120 1 NC_003112.2 identified by similarity to EGAD:5595; match to protein family HMM PF01609; IS1106 transposase 1662120 904284 NMB1601 Neisseria meningitidis MC58 IS1106 transposase NP_274607.1 1661113 D 122586 CDS NP_274608.1 15677452 904293 complement(1662032..1663150) 1 NC_003112.2 identified by similarity to GP:3005554; match to protein family HMM PF01548; match to protein family HMM PF02371; transposase 1663150 904293 NMB1602 Neisseria meningitidis MC58 transposase NP_274608.1 1662032 R 122586 CDS NP_274609.1 15677453 904294 1663327..1664271 1 NC_003112.2 identified by similarity to EGAD:19683; match to protein family HMM PF03595; potassium-tellurite ethidium and proflavin transporter 1664271 904294 NMB1603 Neisseria meningitidis MC58 potassium-tellurite ethidium and proflavin transporter NP_274609.1 1663327 D 122586 CDS NP_274610.1 15677454 904297 complement(1664344..1665027) 1 NC_003112.2 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1665027 gpmA 904297 gpmA Neisseria meningitidis MC58 phosphoglyceromutase NP_274610.1 1664344 R 122586 CDS NP_274611.1 15677455 904301 1665175..1667478 1 NC_003112.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1667478 parC 904301 parC Neisseria meningitidis MC58 DNA topoisomerase IV subunit A NP_274611.1 1665175 D 122586 CDS NP_274612.1 15677456 904302 1667498..1669015 1 NC_003112.2 identified by similarity to EGAD:152602; match to protein family HMM PF00512; sensor histidine kinase 1669015 904302 NMB1606 Neisseria meningitidis MC58 sensor histidine kinase NP_274612.1 1667498 D 122586 CDS NP_274613.1 15677457 904304 1669067..1669534 1 NC_003112.2 identified by similarity to EGAD:21464; match to protein family HMM PF00072; match to protein family HMM PF02954; match to protein family HMM TIGR01199; sigma-54 dependent response regulator 1669534 904304 NMB1607 Neisseria meningitidis MC58 sigma-54 dependent response regulator NP_274613.1 1669067 D 122586 CDS NP_274614.1 15677458 904305 1669638..1670390 1 NC_003112.2 identified by similarity to EGAD:5782; match to protein family HMM PF04445; hypothetical protein 1670390 904305 NMB1608 Neisseria meningitidis MC58 hypothetical protein NP_274614.1 1669638 D 122586 CDS YP_008920719.1 566328933 17925340 complement(1671436..1671642) 1 NC_003112.2 hypothetical protein 1671642 17925340 NMB1608a Neisseria meningitidis MC58 hypothetical protein YP_008920719.1 1671436 R 122586 CDS NP_274615.1 15677459 904307 complement(1671729..1672898) 1 NC_003112.2 identified by similarity to EGAD:150275; match to protein family HMM PF01053; match to protein family HMM TIGR01325; O-succinylhomoserine sulfhydrolase 1672898 904307 NMB1609 Neisseria meningitidis MC58 O-succinylhomoserine sulfhydrolase NP_274615.1 1671729 R 122586 CDS NP_274616.1 15677460 904310 complement(1673043..1673804) 1 NC_003112.2 hypothetical protein 1673804 904310 NMB1610 Neisseria meningitidis MC58 hypothetical protein NP_274616.1 1673043 R 122586 CDS NP_274617.1 15677461 904311 1673904..1674155 1 NC_003112.2 hypothetical protein 1674155 904311 NMB1611 Neisseria meningitidis MC58 hypothetical protein NP_274617.1 1673904 D 122586 CDS NP_274618.1 15677462 902102 1674207..1675013 1 NC_003112.2 identified by similarity to EGAD:8642; match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 1675013 902102 NMB1612 Neisseria meningitidis MC58 amino acid ABC transporter substrate-binding protein NP_274618.1 1674207 D 122586 CDS NP_274619.1 15677463 904181 1675320..1676843 1 NC_003112.2 identified by similarity to SP:P14407; match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723; fumarate hydratase 1676843 fumB 904181 fumB Neisseria meningitidis MC58 fumarate hydratase NP_274619.1 1675320 D 122586 CDS NP_274620.1 15677464 904179 1676941..1678353 1 NC_003112.2 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1678353 trkA 904179 trkA Neisseria meningitidis MC58 potassium transporter peripheral membrane protein NP_274620.1 1676941 D 122586 CDS NP_274622.1 15677466 904166 1679793..1680599 1 NC_003112.2 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1680599 thiD 904166 thiD Neisseria meningitidis MC58 phosphomethylpyrimidine kinase NP_274622.1 1679793 D 122586 CDS NP_274623.1 15677467 904150 complement(1680649..1681518) 1 NC_003112.2 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1681518 904150 NMB1617 Neisseria meningitidis MC58 tellurite resistance protein TehB NP_274623.1 1680649 R 122586 CDS NP_274624.1 15677468 904120 1681632..1682069 1 NC_003112.2 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1682069 rnhA 904120 rnhA Neisseria meningitidis MC58 ribonuclease H NP_274624.1 1681632 D 122586 CDS NP_274625.1 15677469 904072 1682927..1683331 1 NC_003112.2 identified by similarity to EGAD:159687; match to protein family HMM PF01230; hypothetical protein 1683331 904072 NMB1619 Neisseria meningitidis MC58 hypothetical protein NP_274625.1 1682927 D 122586 CDS NP_274626.1 15677470 904061 1683371..1684555 1 NC_003112.2 identified by similarity to GP:3661475; match to protein family HMM PF02016; match to protein family HMM TIGR01409; hypothetical protein 1684555 904061 NMB1620 Neisseria meningitidis MC58 hypothetical protein NP_274626.1 1683371 D 122586 CDS NP_274627.1 15677471 904057 complement(1684618..1685151) 1 NC_003112.2 identified by similarity to EGAD:40773; match to protein family HMM PF00255; glutathione peroxidase 1685151 gpxA 904057 gpxA Neisseria meningitidis MC58 glutathione peroxidase NP_274627.1 1684618 R 122586 CDS NP_274628.1 15677472 904040 complement(1685330..1687585) 1 NC_003112.2 identified by similarity to GP:2584871; nitric oxide reductase 1687585 norB 904040 norB Neisseria meningitidis MC58 nitric oxide reductase NP_274628.1 1685330 R 122586 CDS NP_274629.1 15677473 904036 1687956..1689128 1 NC_003112.2 identified by similarity to EGAD:17111; match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732; match to protein family HMM TIGR02376; major anaerobically induced outer membrane protein 1689128 pan1 904036 pan1 Neisseria meningitidis MC58 major anaerobically induced outer membrane protein NP_274629.1 1687956 D 122586 CDS NP_274630.1 15677474 904034 1689253..1690008 1 NC_003112.2 hypothetical protein 1690008 904034 NMB1624 Neisseria meningitidis MC58 hypothetical protein NP_274630.1 1689253 D 122586 CDS NP_274631.1 15677475 904033 complement(1690733..1691689) 1 NC_003112.2 identified by similarity to EGAD:138632; match to protein family HMM PF01548; match to protein family HMM PF02371; pilin gene inverting protein PivNM-1B 1691689 pivNM-1B 904033 pivNM-1B Neisseria meningitidis MC58 pilin gene inverting protein PivNM-1B NP_274631.1 1690733 R 122586 CDS NP_274632.1 15677476 904031 complement(1691988..1693091) 1 NC_003112.2 identified by similarity to GP:3402502; match to protein family HMM PF05707; hypothetical protein 1693091 904031 NMB1626 Neisseria meningitidis MC58 hypothetical protein NP_274632.1 1691988 R 122586 CDS NP_274633.1 15677477 904011 complement(1693092..1693376) 1 NC_003112.2 identified by similarity to EGAD:69712; hypothetical protein 1693376 904011 NMB1627 Neisseria meningitidis MC58 hypothetical protein NP_274633.1 1693092 R 122586 CDS NP_274634.1 15677478 904007 complement(1693832..1695385) 1 NC_003112.2 identified by similarity to GP:3758871; match to protein family HMM PF05616; tspB protein 1695385 904007 NMB1628 Neisseria meningitidis MC58 tspB protein NP_274634.1 1693832 R 122586 CDS NP_274635.1 15677479 904000 complement(1695363..1695728) 1 NC_003112.2 hypothetical protein 1695728 904000 NMB1629 Neisseria meningitidis MC58 hypothetical protein NP_274635.1 1695363 R 122586 CDS NP_274636.1 15677480 903998 complement(1695793..1696095) 1 NC_003112.2 hypothetical protein 1696095 903998 NMB1630 Neisseria meningitidis MC58 hypothetical protein NP_274636.1 1695793 R 122586 CDS NP_274637.1 15677481 903994 complement(1696123..1696407) 1 NC_003112.2 hypothetical protein 1696407 903994 NMB1631 Neisseria meningitidis MC58 hypothetical protein NP_274637.1 1696123 R 122586 CDS NP_274638.1 15677482 903972 complement(1696590..1696790) 1 NC_003112.2 hypothetical protein 1696790 903972 NMB1632 Neisseria meningitidis MC58 hypothetical protein NP_274638.1 1696590 R 122586 CDS NP_274639.1 15677483 903971 complement(1696794..1697105) 1 NC_003112.2 hypothetical protein 1697105 903971 NMB1633 Neisseria meningitidis MC58 hypothetical protein NP_274639.1 1696794 R 122586 CDS NP_274640.1 15677484 903969 complement(1697126..1698334) 1 NC_003112.2 identified by similarity to GP:3402495; match to protein family HMM PF02486; hypothetical protein 1698334 903969 NMB1634 Neisseria meningitidis MC58 hypothetical protein NP_274640.1 1697126 R 122586 CDS YP_008920720.1 566328934 903962 1700396..1701088 1 NC_003112.2 opacity protein 1701088 903962 NMB1636 Neisseria meningitidis MC58 opacity protein YP_008920720.1 1700396 D 122586 CDS NP_274642.1 15677486 903959 complement(1701289..1701846) 1 NC_003112.2 identified by similarity to EGAD:28537; match to protein family HMM PF00881; hypothetical protein 1701846 903959 NMB1637 Neisseria meningitidis MC58 hypothetical protein NP_274642.1 1701289 R 122586 CDS NP_274643.1 15677487 903951 complement(1701922..1703556) 1 NC_003112.2 identified by similarity to EGAD:20220; match to protein family HMM PF00884; match to protein family HMM PF08019; hypothetical protein 1703556 903951 NMB1638 Neisseria meningitidis MC58 hypothetical protein NP_274643.1 1701922 R 122586 CDS NP_274644.1 15677488 903944 complement(1703630..1703959) 1 NC_003112.2 hypothetical protein 1703959 903944 NMB1639 Neisseria meningitidis MC58 hypothetical protein NP_274644.1 1703630 R 122586 CDS NP_274645.1 15677489 903939 complement(1703959..1705065) 1 NC_003112.2 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1705065 serC 903939 serC Neisseria meningitidis MC58 phosphoserine aminotransferase NP_274645.1 1703959 R 122586 CDS NP_274646.1 15677490 903938 1705412..1705861 1 NC_003112.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1705861 903938 NMB1641 Neisseria meningitidis MC58 hypothetical protein NP_274646.1 1705412 D 122586 CDS NP_274647.1 15677491 903935 1705889..1707391 1 NC_003112.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1707391 nusA 903935 nusA Neisseria meningitidis MC58 transcription elongation factor NusA NP_274647.1 1705889 D 122586 CDS NP_274648.1 15677492 903928 1707403..1710291 1 NC_003112.2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1710291 infB 903928 infB Neisseria meningitidis MC58 translation initiation factor IF-2 NP_274648.1 1707403 D 122586 CDS NP_274649.1 15677493 903472 complement(1710453..1711793) 1 NC_003112.2 hypothetical protein 1711793 903472 NMB1644 Neisseria meningitidis MC58 hypothetical protein NP_274649.1 1710453 R 122586 CDS NP_274650.1 15677494 903471 complement(1711867..1713207) 1 NC_003112.2 hypothetical protein 1713207 903471 NMB1645 Neisseria meningitidis MC58 hypothetical protein NP_274650.1 1711867 R 122586 CDS NP_274651.1 15677495 903470 1713350..1713976 1 NC_003112.2 identified by similarity to EGAD:45741; match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin 1713976 903470 NMB1646 Neisseria meningitidis MC58 hemolysin NP_274651.1 1713350 D 122586 CDS NP_274652.1 15677496 903469 complement(1714040..1715458) 1 NC_003112.2 identified by similarity to EGAD:107412; match to protein family HMM PF01235; match to protein family HMM TIGR00835; amino acid symporter 1715458 903469 NMB1647 Neisseria meningitidis MC58 amino acid symporter NP_274652.1 1714040 R 122586 CDS NP_274653.1 15677497 903468 1715785..1716513 1 NC_003112.2 identified by similarity to EGAD:35798; match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1716513 903468 NMB1648 Neisseria meningitidis MC58 hypothetical protein NP_274653.1 1715785 D 122586 CDS NP_274654.1 15677498 903467 complement(1716572..1717060) 1 NC_003112.2 identified by similarity to EGAD:8910; match to protein family HMM PF02600; disulfide bond formation protein B 1717060 dsbB 903467 dsbB Neisseria meningitidis MC58 disulfide bond formation protein B NP_274654.1 1716572 R 122586 CDS NP_274655.1 15677499 903466 complement(1717751..1718215) 1 NC_003112.2 identified by similarity to EGAD:134822; match to protein family HMM PF01037; leucine-responsive regulatory protein 1718215 lrp 903466 lrp Neisseria meningitidis MC58 leucine-responsive regulatory protein NP_274655.1 1717751 R 122586 CDS NP_274656.1 15677500 903465 1718540..1719598 1 NC_003112.2 identified by similarity to EGAD:154434; match to protein family HMM PF00842; match to protein family HMM PF01168; match to protein family HMM TIGR00492; alanine racemase 1719598 alr 903465 alr Neisseria meningitidis MC58 alanine racemase NP_274656.1 1718540 D 122586 CDS NP_274657.1 15677501 903464 complement(1719662..1721017) 1 NC_003112.2 identified by similarity to EGAD:44268; match to protein family HMM PF05167; hypothetical protein 1721017 903464 NMB1652 Neisseria meningitidis MC58 hypothetical protein NP_274657.1 1719662 R 122586 CDS NP_274658.1 15677502 903463 complement(1721032..1721304) 1 NC_003112.2 ACT domain-containing protein; hypothetical protein 1721304 903463 NMB1653 Neisseria meningitidis MC58 hypothetical protein NP_274658.1 1721032 R 122586 CDS NP_274659.1 15677503 903462 complement(1721430..1722167) 1 NC_003112.2 identified by similarity to EGAD:107986; match to protein family HMM PF07661; hypothetical protein 1722167 903462 NMB1654 Neisseria meningitidis MC58 hypothetical protein NP_274659.1 1721430 R 122586 CDS NP_274660.1 15677504 903461 complement(1722448..1723359) 1 NC_003112.2 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1723359 903461 NMB1655 Neisseria meningitidis MC58 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_274660.1 1722448 R 122586 CDS NP_274661.1 15677505 903460 1723492..1724085 1 NC_003112.2 hypothetical protein 1724085 903460 NMB1656 Neisseria meningitidis MC58 hypothetical protein NP_274661.1 1723492 D 122586 CDS NP_274662.1 15677506 903459 complement(1724748..1725365) 1 NC_003112.2 identified by similarity to EGAD:36757; match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; comE operon protein 1-like protein 1725365 903459 NMB1657 Neisseria meningitidis MC58 comE operon protein 1-like protein NP_274662.1 1724748 R 122586 CDS NP_274663.1 15677507 903453 1731103..1732287 1 NC_003112.2 identified by similarity to EGAD:27976; match to protein family HMM PF02441; match to protein family HMM PF04127; match to protein family HMM TIGR00521; phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase 1732287 coaBC 903453 coaBC Neisseria meningitidis MC58 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase NP_274663.1 1731103 D 122586 CDS NP_274664.1 15677508 903452 complement(1732354..1734510) 1 NC_003112.2 identified by similarity to EGAD:12642; match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 1734510 spoT 903452 spoT Neisseria meningitidis MC58 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase NP_274664.1 1732354 R 122586 CDS NP_274665.1 15677509 903451 complement(1734602..1734808) 1 NC_003112.2 identified by similarity to EGAD:28791; match to protein family HMM PF01192; match to protein family HMM TIGR00690; DNA-directed RNA polymerase subunit omega 1734808 rpoZ 903451 rpoZ Neisseria meningitidis MC58 DNA-directed RNA polymerase subunit omega NP_274665.1 1734602 R 122586 CDS NP_274666.1 15677510 903450 complement(1734867..1735484) 1 NC_003112.2 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1735484 gmk 903450 gmk Neisseria meningitidis MC58 guanylate kinase NP_274666.1 1734867 R 122586 CDS NP_274667.1 15677511 903448 1735645..1736211 1 NC_003112.2 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1736211 apt 903448 apt Neisseria meningitidis MC58 adenine phosphoribosyltransferase NP_274667.1 1735645 D 122586 CDS NP_274668.1 15677512 903447 complement(1736257..1737045) 1 NC_003112.2 identified by similarity to EGAD:107896; match to protein family HMM PF00702; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hypothetical protein 1737045 903447 NMB1663 Neisseria meningitidis MC58 hypothetical protein NP_274668.1 1736257 R 122586 CDS NP_274669.1 15677513 903446 1737370..1738725 1 NC_003112.2 identified by similarity to EGAD:91300; match to protein family HMM PF01136; protease 1738725 903446 NMB1664 Neisseria meningitidis MC58 protease NP_274669.1 1737370 D 122586 CDS NP_274670.1 15677514 903445 complement(1738905..1739291) 1 NC_003112.2 identified by similarity to EGAD:47695; match to protein family HMM PF01850; hypothetical protein 1739291 903445 NMB1665 Neisseria meningitidis MC58 hypothetical protein NP_274670.1 1738905 R 122586 CDS NP_274671.1 15677515 903444 complement(1739288..1739536) 1 NC_003112.2 hypothetical protein 1739536 903444 NMB1666 Neisseria meningitidis MC58 hypothetical protein NP_274671.1 1739288 R 122586 CDS NP_274672.1 15677516 903443 complement(1739893..1740099) 1 NC_003112.2 hypothetical protein 1740099 903443 NMB1667 Neisseria meningitidis MC58 hypothetical protein NP_274672.1 1739893 R 122586 CDS NP_274673.1 15677517 903442 complement(1740259..1742634) 1 NC_003112.2 identified by similarity to EGAD:131251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01786; hemoglobin receptor 1742634 hmbR 903442 hmbR Neisseria meningitidis MC58 hemoglobin receptor NP_274673.1 1740259 R 122586 CDS NP_274674.1 15677518 903441 complement(1742829..1743458) 1 NC_003112.2 identified by similarity to GP:3091146; match to protein family HMM PF01126; heme utilisation protein 1743458 903441 NMB1669 Neisseria meningitidis MC58 heme utilisation protein NP_274674.1 1742829 R 122586 CDS NP_274675.1 15677519 903440 1743744..1745255 1 NC_003112.2 identified by similarity to EGAD:91640; match to protein family HMM PF04403; match to protein family HMM TIGR00155; PqiA family protein 1745255 903440 NMB1670 Neisseria meningitidis MC58 PqiA family protein NP_274675.1 1743744 D 122586 CDS NP_274676.1 15677520 903439 1745248..1746909 1 NC_003112.2 identified by similarity to EGAD:91619; match to protein family HMM PF02470; pqiB protein 1746909 pqiB 903439 pqiB Neisseria meningitidis MC58 pqiB protein NP_274676.1 1745248 D 122586 CDS NP_274677.1 15677521 903438 1746909..1747427 1 NC_003112.2 identified by similarity to EGAD:91019; match to protein family HMM PF03886; hypothetical protein 1747427 903438 NMB1672 Neisseria meningitidis MC58 hypothetical protein NP_274677.1 1746909 D 122586 CDS NP_274678.1 15677522 903437 1747431..1747982 1 NC_003112.2 identified by similarity to EGAD:128731; match to protein family HMM PF03352; DNA-3-methyladenine glycosylase I 1747982 tag 903437 tag Neisseria meningitidis MC58 DNA-3-methyladenine glycosylase I NP_274678.1 1747431 D 122586 CDS NP_274679.1 15677523 903436 1747972..1748613 1 NC_003112.2 identified by similarity to EGAD:18113; match to protein family HMM PF00657; GDSL lipase 1748613 903436 NMB1674 Neisseria meningitidis MC58 GDSL lipase NP_274679.1 1747972 D 122586 CDS NP_274680.1 15677524 903435 1748835..1749143 1 NC_003112.2 hypothetical protein 1749143 903435 NMB1675 Neisseria meningitidis MC58 hypothetical protein NP_274680.1 1748835 D 122586 CDS NP_274681.1 15677525 903433 complement(1752487..1753326) 1 NC_003112.2 identified by similarity to GP:2231996; match to protein family HMM PF00034; cytochrome c5 1753326 903433 NMB1677 Neisseria meningitidis MC58 cytochrome c5 NP_274681.1 1752487 R 122586 CDS NP_274682.1 15677526 903430 complement(1753751..1754944) 1 NC_003112.2 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1754944 tyrB 903430 tyrB Neisseria meningitidis MC58 aromatic amino acid aminotransferase NP_274682.1 1753751 R 122586 CDS NP_274683.1 15677527 903429 complement(1754965..1756053) 1 NC_003112.2 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 1756053 trmA 903429 trmA Neisseria meningitidis MC58 tRNA (uracil-5-)-methyltransferase NP_274683.1 1754965 R 122586 CDS NP_274684.1 15677528 903428 1756200..1757300 1 NC_003112.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1757300 aroC 903428 aroC Neisseria meningitidis MC58 chorismate synthase NP_274684.1 1756200 D 122586 CDS NP_274685.1 15677529 903426 1757392..1757817 1 NC_003112.2 hypothetical protein 1757817 903426 NMB1681 Neisseria meningitidis MC58 hypothetical protein NP_274685.1 1757392 D 122586 CDS NP_274686.1 15677530 903425 complement(1757891..1759876) 1 NC_003112.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1759876 parE 903425 parE Neisseria meningitidis MC58 DNA topoisomerase IV subunit B NP_274686.1 1757891 R 122586 CDS NP_274687.1 15677531 903424 complement(1759943..1760467) 1 NC_003112.2 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1760467 903424 NMB1683 Neisseria meningitidis MC58 dinucleoside polyphosphate hydrolase NP_274687.1 1759943 R 122586 CDS NP_274688.1 15677532 903423 1760633..1761928 1 NC_003112.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1761928 serS 903423 serS Neisseria meningitidis MC58 seryl-tRNA synthetase NP_274688.1 1760633 D 122586 CDS NP_274689.1 15677533 903422 complement(1762006..1763004) 1 NC_003112.2 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 1763004 ldhA 903422 ldhA Neisseria meningitidis MC58 D-lactate dehydrogenase NP_274689.1 1762006 R 122586 CDS NP_274690.1 15677534 903421 complement(1763129..1764205) 1 NC_003112.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1764205 prfA 903421 prfA Neisseria meningitidis MC58 peptide chain release factor 1 NP_274690.1 1763129 R 122586 CDS NP_274691.1 15677535 903420 complement(1764310..1765080) 1 NC_003112.2 identified by similarity to EGAD:17549; match to protein family HMM PF01026; hypothetical protein 1765080 903420 NMB1687 Neisseria meningitidis MC58 hypothetical protein NP_274691.1 1764310 R 122586 CDS NP_274692.1 15677536 903419 complement(1765088..1766089) 1 NC_003112.2 identified by similarity to EGAD:9104; match to protein family HMM PF00710; L-asparaginase 1766089 ansA 903419 ansA Neisseria meningitidis MC58 L-asparaginase NP_274692.1 1765088 R 122586 CDS NP_274693.1 15677537 903418 complement(1766362..1767045) 1 NC_003112.2 identified by similarity to EGAD:28619; match to protein family HMM PF00597; dedA protein 1767045 903418 NMB1689 Neisseria meningitidis MC58 dedA protein NP_274693.1 1766362 R 122586 CDS NP_274694.1 15677538 903417 complement(1767236..1768570) 1 NC_003112.2 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1768570 glmM 903417 glmM Neisseria meningitidis MC58 phosphoglucosamine mutase NP_274694.1 1767236 R 122586 CDS NP_274695.1 15677539 903415 complement(1768700..1769557) 1 NC_003112.2 identified by similarity to EGAD:13523; match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 1769557 folP 903415 folP Neisseria meningitidis MC58 dihydropteroate synthase NP_274695.1 1768700 R 122586 CDS NP_274696.1 15677540 903413 complement(1769697..1770590) 1 NC_003112.2 identified by similarity to EGAD:164552; chorismate mutase-related protein 1770590 903413 NMB1692 Neisseria meningitidis MC58 chorismate mutase-related protein NP_274696.1 1769697 R 122586 CDS NP_274697.1 15677541 903412 1770681..1772795 1 NC_003112.2 hypothetical protein 1772795 903412 NMB1693 Neisseria meningitidis MC58 hypothetical protein NP_274697.1 1770681 D 122586 CDS NP_274698.1 15677542 903410 complement(1772859..1774343) 1 NC_003112.2 identified by similarity to EGAD:91077; match to protein family HMM PF01977; match to protein family HMM TIGR00148; hypothetical protein 1774343 903410 NMB1694 Neisseria meningitidis MC58 hypothetical protein NP_274698.1 1772859 R 122586 CDS YP_008920721.1 566328935 17925341 complement(1774357..1774872) 1 NC_003112.2 hypothetical protein 1774872 17925341 NMB1696a Neisseria meningitidis MC58 hypothetical protein YP_008920721.1 1774357 R 122586 CDS YP_008920722.1 566328936 17925343 complement(1774879..1775313) 1 NC_003112.2 hypothetical protein 1775313 17925343 NMB1696b Neisseria meningitidis MC58 hypothetical protein YP_008920722.1 1774879 R 122586 CDS NP_274700.1 15677544 903408 complement(1775593..1775838) 1 NC_003112.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1775838 acp-2 903408 acp-2 Neisseria meningitidis MC58 acyl carrier protein NP_274700.1 1775593 R 122586 CDS NP_274701.1 15677545 903406 complement(1775850..1776110) 1 NC_003112.2 identified by similarity to EGAD:131410; acyl carrier protein 1776110 903406 NMB1697 Neisseria meningitidis MC58 acyl carrier protein NP_274701.1 1775850 R 122586 CDS NP_274702.1 15677546 903405 complement(1776107..1776865) 1 NC_003112.2 identified by similarity to EGAD:90492; match to protein family HMM PF01553; acyltransferase 1776865 903405 NMB1698 Neisseria meningitidis MC58 acyltransferase NP_274702.1 1776107 R 122586 CDS NP_274703.2 566328907 903404 complement(1776858..1777613) 1 NC_003112.2 hypothetical protein 1777613 903404 NMB1699 Neisseria meningitidis MC58 hypothetical protein NP_274703.2 1776858 R 122586 CDS NP_274705.1 15677549 903402 1777801..1778301 1 NC_003112.2 hypothetical protein 1778301 903402 NMB1701 Neisseria meningitidis MC58 hypothetical protein NP_274705.1 1777801 D 122586 CDS NP_274706.1 15677550 903401 1778329..1779057 1 NC_003112.2 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1779057 fabG 903401 fabG Neisseria meningitidis MC58 3-ketoacyl-ACP reductase NP_274706.1 1778329 D 122586 CDS NP_274707.1 15677551 903400 1779051..1780301 1 NC_003112.2 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1780301 fabF-2 903400 fabF-2 Neisseria meningitidis MC58 3-oxoacyl-ACP synthase NP_274707.1 1779051 D 122586 CDS NP_274708.1 15677552 903398 1780505..1781263 1 NC_003112.2 identified by similarity to EGAD:124882; match to protein family HMM PF00535; beta-1,4-glucosyltransferase 1781263 lgtF 903398 lgtF Neisseria meningitidis MC58 beta-1,4-glucosyltransferase NP_274708.1 1780505 D 122586 CDS NP_274709.1 15677553 903397 1781264..1782328 1 NC_003112.2 identified by similarity to EGAD:40699; match to protein family HMM PF00534; alpha 1,2 N-acetylglucosamine transferase 1782328 rfaK 903397 rfaK Neisseria meningitidis MC58 alpha 1,2 N-acetylglucosamine transferase NP_274709.1 1781264 D 122586 CDS NP_274710.1 15677554 903395 1782367..1782537 1 NC_003112.2 hypothetical protein 1782537 903395 NMB1706 Neisseria meningitidis MC58 hypothetical protein NP_274710.1 1782367 D 122586 CDS NP_274711.1 15677555 903394 1782715..1784052 1 NC_003112.2 identified by similarity to EGAD:109240; match to protein family HMM PF00209; sodium- and chloride-dependent transporter 1784052 903394 NMB1707 Neisseria meningitidis MC58 sodium- and chloride-dependent transporter NP_274711.1 1782715 D 122586 CDS NP_274712.1 15677556 903393 complement(1784892..1785686) 1 NC_003112.2 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1785686 thyA 903393 thyA Neisseria meningitidis MC58 thymidylate synthase NP_274712.1 1784892 R 122586 CDS NP_274713.1 15677557 903392 1786070..1787404 1 NC_003112.2 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1787404 gdhA 903392 gdhA Neisseria meningitidis MC58 glutamate dehydrogenase NP_274713.1 1786070 D 122586 CDS NP_274714.1 15677558 903391 complement(1787539..1788318) 1 NC_003112.2 identified by similarity to EGAD:37331; match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 1788318 903391 NMB1711 Neisseria meningitidis MC58 GntR family transcriptional regulator NP_274714.1 1787539 R 122586 CDS NP_274715.1 15677559 903390 1788749..1789048 1 NC_003112.2 identified by similarity to EGAD:36535; L-lactate permease-like protein 1789048 903390 NMB1712 Neisseria meningitidis MC58 L-lactate permease-like protein NP_274715.1 1788749 D 122586 CDS NP_274716.1 15677560 903389 complement(1789434..1790399) 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1790399 903389 NMB1713 Neisseria meningitidis MC58 IS30 family transposase NP_274716.1 1789434 R 122586 CDS NP_274717.1 15677561 903388 complement(1790509..1791912) 1 NC_003112.2 identified by similarity to EGAD:17129; match to protein family HMM PF02321; match to protein family HMM TIGR01845; multidrug efflux pump channel protein 1791912 mtrE 903388 mtrE Neisseria meningitidis MC58 multidrug efflux pump channel protein NP_274717.1 1790509 R 122586 CDS NP_274718.1 15677562 903387 complement(1791967..1795170) 1 NC_003112.2 identified by similarity to EGAD:152391; match to protein family HMM PF00873; match to protein family HMM TIGR00915; multiple transferable resistance system protein MtrD 1795170 mtrD 903387 mtrD Neisseria meningitidis MC58 multiple transferable resistance system protein MtrD NP_274718.1 1791967 R 122586 CDS NP_274719.1 15677563 903386 complement(1795182..1796420) 1 NC_003112.2 identified by similarity to EGAD:12931; match to protein family HMM PF00529; match to protein family HMM TIGR01730; membrane fusion protein 1796420 mtrC 903386 mtrC Neisseria meningitidis MC58 membrane fusion protein NP_274719.1 1795182 R 122586 CDS NP_274720.1 15677564 903385 1796823..1797455 1 NC_003112.2 identified by similarity to EGAD:19994; match to protein family HMM PF00440; transcriptional regulator MtrR 1797455 mtrR 903385 mtrR Neisseria meningitidis MC58 transcriptional regulator MtrR NP_274720.1 1796823 D 122586 CDS NP_274721.1 15677565 903383 complement(1797734..1797991) 1 NC_003112.2 hypothetical protein 1797991 903383 NMB1718 Neisseria meningitidis MC58 hypothetical protein NP_274721.1 1797734 R 122586 CDS NP_274722.1 15677566 903382 1798278..1799846 1 NC_003112.2 identified by similarity to GP:5764655; match to protein family HMM PF03806; match to protein family HMM TIGR00819; efflux pump component MtrF 1799846 mtrF 903382 mtrF Neisseria meningitidis MC58 efflux pump component MtrF NP_274722.1 1798278 D 122586 CDS NP_274723.1 15677567 903381 complement(1799914..1803123) 1 NC_003112.2 identified by similarity to EGAD:8221; match to protein family HMM PF04257; match to protein family HMM TIGR01450; exodeoxyribonuclease V 125 kD polypeptide 1803123 recC 903381 recC Neisseria meningitidis MC58 exodeoxyribonuclease V 125 kD polypeptide NP_274723.1 1799914 R 122586 CDS NP_274724.1 15677568 903380 complement(1803225..1804634) 1 NC_003112.2 identified by similarity to EGAD:140494; match to protein family HMM PF03929; hypothetical protein 1804634 903380 NMB1721 Neisseria meningitidis MC58 hypothetical protein NP_274724.1 1803225 R 122586 CDS NP_274726.1 15677569 903379 complement(1805070..1806167) 1 NC_003112.2 identified by similarity to EGAD:24821; match to protein family HMM PF00034; match to protein family HMM TIGR00782; cytochrome c oxidase subunit III 1806167 fixP 903379 fixP Neisseria meningitidis MC58 cytochrome c oxidase subunit III NP_274726.1 1805070 R 122586 CDS YP_008920723.1 566328937 17925342 complement(1806191..1806361) 1 NC_003112.2 Cbb3-type cytochrome oxidase subunit 3 1806361 17925342 NMB1723a Neisseria meningitidis MC58 Cbb3-type cytochrome oxidase subunit 3 YP_008920723.1 1806191 R 122586 CDS NP_274727.1 15677570 903378 complement(1806366..1806977) 1 NC_003112.2 CcoO; FixO; cbb3-type cytochrome c oxidase subunit II 1806977 fixO 903378 fixO Neisseria meningitidis MC58 cbb3-type cytochrome c oxidase subunit II NP_274727.1 1806366 R 122586 CDS NP_274728.1 15677571 903376 complement(1807004..1808449) 1 NC_003112.2 CcoN; FixN; cbb3-type cytochrome c oxidase subunit I 1808449 fixN 903376 fixN Neisseria meningitidis MC58 cbb3-type cytochrome c oxidase subunit I NP_274728.1 1807004 R 122586 CDS NP_274729.1 15677572 903375 1808764..1810512 1 NC_003112.2 identified by similarity to EGAD:36443; match to protein family HMM PF05299; hypothetical protein 1810512 903375 NMB1726 Neisseria meningitidis MC58 hypothetical protein NP_274729.1 1808764 D 122586 CDS NP_274730.1 15677573 903372 1810577..1811005 1 NC_003112.2 identified by similarity to GP:2564977; match to protein family HMM PF04273; match to protein family HMM TIGR01244; hypothetical protein 1811005 903372 NMB1727 Neisseria meningitidis MC58 hypothetical protein NP_274730.1 1810577 D 122586 CDS NP_274731.1 15677574 903371 complement(1811692..1812126) 1 NC_003112.2 identified by similarity to EGAD:145337; match to protein family HMM PF02472; biopolymer transport protein 1812126 exbD 903371 exbD Neisseria meningitidis MC58 biopolymer transport protein NP_274731.1 1811692 R 122586 CDS NP_274732.1 15677575 903370 complement(1812129..1812791) 1 NC_003112.2 identified by similarity to EGAD:145333; match to protein family HMM PF01618; biopolymer transport protein 1812791 exbB 903370 exbB Neisseria meningitidis MC58 biopolymer transport protein NP_274732.1 1812129 R 122586 CDS NP_274733.1 15677576 903369 complement(1812857..1813699) 1 NC_003112.2 identified by similarity to EGAD:153359; match to protein family HMM PF03544; match to protein family HMM TIGR01352; TonB protein 1813699 tonB 903369 tonB Neisseria meningitidis MC58 TonB protein NP_274733.1 1812857 R 122586 CDS NP_274734.1 15677577 903368 1813954..1814592 1 NC_003112.2 identified by similarity to EGAD:156566; match to protein family HMM PF02163; hypothetical protein 1814592 903368 NMB1731 Neisseria meningitidis MC58 hypothetical protein NP_274734.1 1813954 D 122586 CDS NP_274735.1 15677578 903367 complement(1815044..1815844) 1 NC_003112.2 identified by similarity to EGAD:135324; transporter 1815844 903367 NMB1732 Neisseria meningitidis MC58 transporter NP_274735.1 1815044 R 122586 CDS NP_274736.1 15677579 903366 complement(1815980..1816483) 1 NC_003112.2 hypothetical protein 1816483 903366 NMB1733 Neisseria meningitidis MC58 hypothetical protein NP_274736.1 1815980 R 122586 CDS NP_274737.1 15677580 903365 complement(1816820..1817461) 1 NC_003112.2 cofactor involved in the reduction of disulfides; glutaredoxin 1817461 grx 903365 grx Neisseria meningitidis MC58 glutaredoxin NP_274737.1 1816820 R 122586 CDS NP_274738.1 15677581 903364 1817604..1819817 1 NC_003112.2 identified by similarity to GP:2739435; match to protein family HMM PF01842; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; GTP pyrophosphokinase 1819817 relA 903364 relA Neisseria meningitidis MC58 GTP pyrophosphokinase NP_274738.1 1817604 D 122586 CDS YP_008920724.1 566328938 903363 1820322..1820897 1 NC_003112.2 hypothetical protein 1820897 903363 NMB1736 Neisseria meningitidis MC58 hypothetical protein YP_008920724.1 1820322 D 122586 CDS NP_274739.1 15677582 903362 complement(1821061..1822464) 1 NC_003112.2 identified by similarity to EGAD:40992; match to protein family HMM PF02321; secretion protein 1822464 903362 NMB1737 Neisseria meningitidis MC58 secretion protein NP_274739.1 1821061 R 122586 CDS NP_274740.1 15677583 903361 complement(1822533..1823960) 1 NC_003112.2 identified by similarity to GP:558154; match to protein family HMM PF00529; match to protein family HMM TIGR01843; secretion protein 1823960 903361 NMB1738 Neisseria meningitidis MC58 secretion protein NP_274740.1 1822533 R 122586 CDS NP_274741.1 15677584 903360 1824196..1824549 1 NC_003112.2 hypothetical protein 1824549 903360 NMB1739 Neisseria meningitidis MC58 hypothetical protein NP_274741.1 1824196 D 122586 CDS YP_008920725.1 566328939 903358 1825462..1826496 1 NC_003112.2 hypothetical protein 1826496 903358 NMB1741 Neisseria meningitidis MC58 hypothetical protein YP_008920725.1 1825462 D 122586 CDS NP_274743.1 15677586 903356 1826541..1826831 1 NC_003112.2 hypothetical protein 1826831 903356 NMB1742 Neisseria meningitidis MC58 hypothetical protein NP_274743.1 1826541 D 122586 CDS NP_274744.1 15677587 903355 1826836..1827033 1 NC_003112.2 hypothetical protein 1827033 903355 NMB1743 Neisseria meningitidis MC58 hypothetical protein NP_274744.1 1826836 D 122586 CDS NP_274745.1 15677588 903353 1827041..1827325 1 NC_003112.2 hypothetical protein 1827325 903353 NMB1744 Neisseria meningitidis MC58 hypothetical protein NP_274745.1 1827041 D 122586 CDS NP_274746.1 15677589 903352 1827332..1827610 1 NC_003112.2 hypothetical protein 1827610 903352 NMB1745 Neisseria meningitidis MC58 hypothetical protein NP_274746.1 1827332 D 122586 CDS NP_274748.1 15677591 903350 1828069..1829574 1 NC_003112.2 identified by similarity to GP:3758871; match to protein family HMM PF05616; tspB protein 1829574 903350 NMB1747 Neisseria meningitidis MC58 tspB protein NP_274748.1 1828069 D 122586 CDS NP_274749.1 15677592 903349 1829575..1829865 1 NC_003112.2 identified by similarity to EGAD:69712; hypothetical protein 1829865 903349 NMB1748 Neisseria meningitidis MC58 hypothetical protein NP_274749.1 1829575 D 122586 CDS NP_274750.1 15677593 903348 1829875..1830960 1 NC_003112.2 identified by similarity to GP:3402502; match to protein family HMM PF05707; hypothetical protein 1830960 903348 NMB1749 Neisseria meningitidis MC58 hypothetical protein NP_274750.1 1829875 D 122586 CDS NP_274751.1 15677594 903347 1831586..1832536 1 NC_003112.2 identified by similarity to EGAD:138632; match to protein family HMM PF01548; match to protein family HMM PF02371; pilin gene inverting protein PivNM-2 1832536 pivNM-2 903347 pivNM-2 Neisseria meningitidis MC58 pilin gene inverting protein PivNM-2 NP_274751.1 1831586 D 122586 CDS NP_274753.1 15677595 903345 1834685..1835122 1 NC_003112.2 identified by similarity to EGAD:153654; match to protein family HMM PF04605; VapD-like protein 1835122 903345 NMB1753 Neisseria meningitidis MC58 VapD-like protein NP_274753.1 1834685 D 122586 CDS NP_274754.1 15677596 903344 complement(1835119..1835220) 1 NC_003112.2 identified by similarity to EGAD:7068; cryptic plasmid protein A-like protein 1835220 903344 NMB1754 Neisseria meningitidis MC58 cryptic plasmid protein A-like protein NP_274754.1 1835119 R 122586 CDS NP_274756.1 15677598 903342 1836018..1836212 1 NC_003112.2 hypothetical protein 1836212 903342 NMB1756 Neisseria meningitidis MC58 hypothetical protein NP_274756.1 1836018 D 122586 CDS NP_274759.1 15677601 903339 1837441..1838805 1 NC_003112.2 identified by similarity to GP:3329425; match to protein family HMM PF02661; hypothetical protein 1838805 903339 NMB1759 Neisseria meningitidis MC58 hypothetical protein NP_274759.1 1837441 D 122586 CDS NP_274760.1 15677602 903338 1839166..1839672 1 NC_003112.2 identified by similarity to EGAD:166833; hypothetical protein 1839672 903338 NMB1760 Neisseria meningitidis MC58 hypothetical protein NP_274760.1 1839166 D 122586 CDS NP_274761.1 15677603 903337 1839835..1841088 1 NC_003112.2 identified by similarity to EGAD:97133; match to protein family HMM PF07804; match to protein family HMM PF07805; hypothetical protein 1841088 903337 NMB1761 Neisseria meningitidis MC58 hypothetical protein NP_274761.1 1839835 D 122586 CDS NP_274762.1 15677604 903336 complement(1841413..1843200) 1 NC_003112.2 identified by similarity to EGAD:149243; match to protein family HMM PF03865; hemolysin activation protein HecB 1843200 903336 NMB1762 Neisseria meningitidis MC58 hemolysin activation protein HecB NP_274762.1 1841413 R 122586 CDS NP_274763.1 15677605 903335 complement(1843255..1843713) 1 NC_003112.2 identified by similarity to EGAD:41441; match to protein family HMM PF02794; toxin-activating protein 1843713 903335 NMB1763 Neisseria meningitidis MC58 toxin-activating protein NP_274763.1 1843255 R 122586 CDS NP_274765.1 15677607 903333 complement(1844205..1844504) 1 NC_003112.2 hypothetical protein 1844504 903333 NMB1765 Neisseria meningitidis MC58 hypothetical protein NP_274765.1 1844205 R 122586 CDS NP_274766.1 15677608 903332 complement(1844485..1845498) 1 NC_003112.2 hypothetical protein 1845498 903332 NMB1766 Neisseria meningitidis MC58 hypothetical protein NP_274766.1 1844485 R 122586 CDS NP_274767.1 15677609 903331 complement(1845567..1845983) 1 NC_003112.2 hypothetical protein 1845983 903331 NMB1767 Neisseria meningitidis MC58 hypothetical protein NP_274767.1 1845567 R 122586 CDS NP_274768.1 15677610 903330 complement(1845987..1853531) 1 NC_003112.2 identified by similarity to EGAD:18919; match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01731; match to protein family HMM TIGR01901; hemagglutinin/hemolysin-like protein 1853531 903330 NMB1768 Neisseria meningitidis MC58 hemagglutinin/hemolysin-like protein NP_274768.1 1845987 R 122586 CDS NP_274770.1 15677611 903329 1854110..1855075 1 NC_003112.2 identified by similarity to EGAD:18338; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 1855075 903329 NMB1770 Neisseria meningitidis MC58 IS30 family transposase NP_274770.1 1854110 D 122586 CDS NP_274771.1 15677612 903328 complement(1855143..1855577) 1 NC_003112.2 hypothetical protein 1855577 903328 NMB1771 Neisseria meningitidis MC58 hypothetical protein NP_274771.1 1855143 R 122586 CDS NP_274772.1 15677613 903327 complement(1855574..1857412) 1 NC_003112.2 hypothetical protein 1857412 903327 NMB1772 Neisseria meningitidis MC58 hypothetical protein NP_274772.1 1855574 R 122586 CDS NP_274773.1 15677614 903326 complement(1857447..1857821) 1 NC_003112.2 hypothetical protein 1857821 903326 NMB1773 Neisseria meningitidis MC58 hypothetical protein NP_274773.1 1857447 R 122586 CDS NP_274774.1 15677615 903325 complement(1858099..1858476) 1 NC_003112.2 hypothetical protein 1858476 903325 NMB1774 Neisseria meningitidis MC58 hypothetical protein NP_274774.1 1858099 R 122586 CDS NP_274775.1 15677616 903324 complement(1858485..1860290) 1 NC_003112.2 hypothetical protein 1860290 903324 NMB1775 Neisseria meningitidis MC58 hypothetical protein NP_274775.1 1858485 R 122586 CDS NP_274776.1 15677617 903323 complement(1860287..1860391) 1 NC_003112.2 hypothetical protein 1860391 903323 NMB1776 Neisseria meningitidis MC58 hypothetical protein NP_274776.1 1860287 R 122586 CDS NP_274777.2 566328906 903322 complement(1861157..1861531) 1 NC_003112.2 hypothetical protein 1861531 903322 NMB1777 Neisseria meningitidis MC58 hypothetical protein NP_274777.2 1861157 R 122586 CDS NP_274778.1 15677619 903321 complement(1861423..1861527) 1 NC_003112.2 hypothetical protein 1861527 903321 NMB1778 Neisseria meningitidis MC58 hypothetical protein NP_274778.1 1861423 R 122586 CDS NP_274779.1 15677620 903320 complement(1861550..1867537) 1 NC_003112.2 identified by similarity to GP:2623258; match to protein family HMM PF04829; match to protein family HMM PF04830; match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01901; hemagglutinin/hemolysin-like protein 1867537 903320 NMB1779 Neisseria meningitidis MC58 hemagglutinin/hemolysin-like protein NP_274779.1 1861550 R 122586 CDS NP_274780.1 15677621 903319 complement(1867646..1869388) 1 NC_003112.2 identified by similarity to EGAD:131262; match to protein family HMM PF03865; hemolysin activation protein HecB 1869388 903319 NMB1780 Neisseria meningitidis MC58 hemolysin activation protein HecB NP_274780.1 1867646 R 122586 CDS NP_274781.1 15677622 903318 complement(1869787..1869957) 1 NC_003112.2 hypothetical protein 1869957 903318 NMB1781 Neisseria meningitidis MC58 hypothetical protein NP_274781.1 1869787 R 122586 CDS NP_274782.1 15677623 903317 complement(1869972..1870274) 1 NC_003112.2 hypothetical protein 1870274 903317 NMB1782 Neisseria meningitidis MC58 hypothetical protein NP_274782.1 1869972 R 122586 CDS NP_274783.1 15677624 903315 complement(1871925..1872278) 1 NC_003112.2 hypothetical protein 1872278 903315 NMB1784 Neisseria meningitidis MC58 hypothetical protein NP_274783.1 1871925 R 122586 CDS NP_274784.1 15677625 903314 complement(1872271..1872510) 1 NC_003112.2 hypothetical protein 1872510 903314 NMB1785 Neisseria meningitidis MC58 hypothetical protein NP_274784.1 1872271 R 122586 CDS NP_274785.1 15677626 903313 complement(1872507..1873661) 1 NC_003112.2 hypothetical protein 1873661 903313 NMB1786 Neisseria meningitidis MC58 hypothetical protein NP_274785.1 1872507 R 122586 CDS NP_274786.1 15677627 903312 1874194..1875237 1 NC_003112.2 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1875237 argC 903312 argC Neisseria meningitidis MC58 N-acetyl-gamma-glutamyl-phosphate reductase NP_274786.1 1874194 D 122586 CDS NP_274787.1 15677628 903311 complement(1876300..1878342) 1 NC_003112.2 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1878342 recG 903311 recG Neisseria meningitidis MC58 ATP-dependent DNA helicase RecG NP_274787.1 1876300 R 122586 CDS NP_274788.1 15677629 903310 complement(1878428..1878871) 1 NC_003112.2 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1878871 secB 903310 secB Neisseria meningitidis MC58 preprotein translocase subunit SecB NP_274788.1 1878428 R 122586 CDS NP_274789.1 15677630 903309 complement(1878892..1879149) 1 NC_003112.2 identified by similarity to EGAD:5821; match to protein family HMM PF00462; match to protein family HMM TIGR02181; glutaredoxin 3 1879149 grxC 903309 grxC Neisseria meningitidis MC58 glutaredoxin 3 NP_274789.1 1878892 R 122586 CDS NP_274790.1 15677631 903308 1879326..1880855 1 NC_003112.2 identified by similarity to EGAD:10184; match to protein family HMM TIGR00757; cytoplasmic axial filament protein 1880855 cafA 903308 cafA Neisseria meningitidis MC58 cytoplasmic axial filament protein NP_274790.1 1879326 D 122586 CDS NP_274791.2 566328905 903307 complement(1880890..1882140) 1 NC_003112.2 identified by similarity to EGAD:28685; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 1882140 903307 NMB1792 Neisseria meningitidis MC58 sensor histidine kinase NP_274791.2 1880890 R 122586 CDS NP_274792.1 15677633 903305 complement(1882534..1883847) 1 NC_003112.2 identified by similarity to EGAD:45968; match to protein family HMM PF03600; match to protein family HMM TIGR00784; citrate transporter 1883847 903305 NMB1794 Neisseria meningitidis MC58 citrate transporter NP_274792.1 1882534 R 122586 CDS NP_274794.1 15677635 903303 complement(1884417..1884989) 1 NC_003112.2 identified by similarity to EGAD:20585; match to protein family HMM PF03358; hypothetical protein 1884989 903303 NMB1796 Neisseria meningitidis MC58 hypothetical protein NP_274794.1 1884417 R 122586 CDS NP_274795.1 15677636 903302 1885148..1886557 1 NC_003112.2 identified by similarity to GP:3249049; match to protein family HMM PF02113; match to protein family HMM TIGR00666; penicillin-binding protein 3 1886557 903302 NMB1797 Neisseria meningitidis MC58 penicillin-binding protein 3 NP_274795.1 1885148 D 122586 CDS NP_274796.1 15677637 903300 complement(1887524..1888693) 1 NC_003112.2 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1888693 metK 903300 metK Neisseria meningitidis MC58 S-adenosylmethionine synthetase NP_274796.1 1887524 R 122586 CDS NP_274798.1 15677639 903297 1889039..1889935 1 NC_003112.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1889935 903297 NMB1801 Neisseria meningitidis MC58 lipid A biosynthesis lauroyl acyltransferase NP_274798.1 1889039 D 122586 CDS NP_274799.1 15677640 903296 complement(1889979..1891043) 1 NC_003112.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 1891043 gcp 903296 gcp Neisseria meningitidis MC58 DNA-binding/iron metalloprotein/AP endonuclease NP_274799.1 1889979 R 122586 CDS NP_274800.1 15677641 903295 complement(1891160..1892347) 1 NC_003112.2 identified by similarity to GP:3790606; match to protein family HMM PF01578; cytochrome c-type biogenesis protein 1892347 903295 NMB1803 Neisseria meningitidis MC58 cytochrome c-type biogenesis protein NP_274800.1 1891160 R 122586 CDS NP_274801.1 15677642 903294 complement(1892340..1894355) 1 NC_003112.2 identified by similarity to GP:3790604; match to protein family HMM PF05140; cytochrome c-type biogenesis protein 1894355 903294 NMB1804 Neisseria meningitidis MC58 cytochrome c-type biogenesis protein NP_274801.1 1892340 R 122586 CDS NP_274802.1 15677643 903293 complement(1894569..1895192) 1 NC_003112.2 identified by similarity to EGAD:18580; match to protein family HMM PF00034; cytochrome c4 1895192 903293 NMB1805 Neisseria meningitidis MC58 cytochrome c4 NP_274802.1 1894569 R 122586 CDS NP_274803.1 15677644 903292 1895392..1896027 1 NC_003112.2 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1896027 engB 903292 engB Neisseria meningitidis MC58 ribosome biogenesis GTP-binding protein YsxC NP_274803.1 1895392 D 122586 CDS NP_274804.1 15677645 903291 complement(1896148..1898544) 1 NC_003112.2 identified by similarity to EGAD:138031; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1 1898544 ponA 903291 ponA Neisseria meningitidis MC58 penicillin-binding protein 1 NP_274804.1 1896148 R 122586 CDS NP_274805.1 15677646 903290 1898696..1899811 1 NC_003112.2 identified by similarity to EGAD:151887; match to protein family HMM TIGR01175; pilM protein 1899811 pilM 903290 pilM Neisseria meningitidis MC58 pilM protein NP_274805.1 1898696 D 122586 CDS NP_274806.1 15678015 903123 1899814..1900413 1 NC_003112.2 identified by similarity to EGAD:151888; match to protein family HMM PF05137; pilN protein 1900413 pilN 903123 pilN Neisseria meningitidis MC58 pilN protein NP_274806.1 1899814 D 122586 CDS NP_274807.1 15677647 903289 1900414..1901061 1 NC_003112.2 identified by similarity to GP:1914829; match to protein family HMM PF04350; pilO protein 1901061 pilO 903289 pilO Neisseria meningitidis MC58 pilO protein NP_274807.1 1900414 D 122586 CDS NP_274808.1 15677648 903288 1901079..1901624 1 NC_003112.2 identified by similarity to EGAD:40689; match to protein family HMM PF04351; pilP protein 1901624 pilP 903288 pilP Neisseria meningitidis MC58 pilP protein NP_274808.1 1901079 D 122586 CDS NP_274809.1 15678016 903122 1901643..1903952 1 NC_003112.2 This PilQ differs from other reported Neisseria PilQ sequences primarily in the length of a repeat region and in the reading frame at the extreme C-terminus, where this sequence follows the consensus of homologs from non-Neisserial species.; identified by similarity to EGAD:40690; match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM PF07660; match to protein family HMM TIGR02515; pilQ protein 1903952 pilQ 903122 pilQ Neisseria meningitidis MC58 pilQ protein NP_274809.1 1901643 D 122586 CDS NP_274810.1 15677649 903287 1904854..1905366 1 NC_003112.2 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 1905366 aroK 903287 aroK Neisseria meningitidis MC58 shikimate kinase NP_274810.1 1904854 D 122586 CDS NP_274811.1 15677650 903286 1905446..1906525 1 NC_003112.2 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1906525 aroB 903286 aroB Neisseria meningitidis MC58 3-dehydroquinate synthase NP_274811.1 1905446 D 122586 CDS NP_274812.1 15677651 903285 1907492..1908334 1 NC_003112.2 identified by similarity to GP:2661442; match to protein family HMM PF00310; hypothetical protein 1908334 903285 NMB1815 Neisseria meningitidis MC58 hypothetical protein NP_274812.1 1907492 D 122586 CDS NP_274813.1 15677652 903284 1908364..1908828 1 NC_003112.2 identified by similarity to GP:2661443; match to protein family HMM PF03477; transcriptional regulator NrdR 1908828 nrdR 903284 nrdR Neisseria meningitidis MC58 transcriptional regulator NrdR NP_274813.1 1908364 D 122586 CDS NP_274814.1 15677653 903283 1908860..1909969 1 NC_003112.2 identified by similarity to EGAD:27967; match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD 1909969 ribD 903283 ribD Neisseria meningitidis MC58 riboflavin biosynthesis protein RibD NP_274814.1 1908860 D 122586 CDS NP_274815.1 15677654 903282 1910164..1911585 1 NC_003112.2 identified by similarity to EGAD:165571; match to protein family HMM PF01943; lipopolysaccharide biosynthesis protein 1911585 903282 NMB1818 Neisseria meningitidis MC58 lipopolysaccharide biosynthesis protein NP_274815.1 1910164 D 122586 CDS NP_274816.1 15677655 903281 1911582..1911737 1 NC_003112.2 hypothetical protein 1911737 903281 NMB1819 Neisseria meningitidis MC58 hypothetical protein NP_274816.1 1911582 D 122586 CDS NP_274817.1 15677656 903280 1911753..1912994 1 NC_003112.2 identified by similarity to GB:3299889; match to protein family HMM PF00132; match to protein family HMM PF02397; pilin glycosylation protein PglB 1912994 pglB 903280 pglB Neisseria meningitidis MC58 pilin glycosylation protein PglB NP_274817.1 1911753 D 122586 CDS NP_274818.1 15677657 903279 1913127..1914302 1 NC_003112.2 identified by similarity to GP:3299890; match to protein family HMM PF01041; pilin glycosylation protein 1914302 pglC 903279 pglC Neisseria meningitidis MC58 pilin glycosylation protein NP_274818.1 1913127 D 122586 CDS NP_274819.1 15677658 903278 1914350..1916260 1 NC_003112.2 identified by similarity to GP:3299891; match to protein family HMM PF02719; match to protein family HMM PF07993; pilin glycosylation protein 1916260 pglD 903278 pglD Neisseria meningitidis MC58 pilin glycosylation protein NP_274819.1 1914350 D 122586 CDS NP_274820.1 15677659 903277 1916316..1917608 1 NC_003112.2 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 1917608 avtA 903277 avtA Neisseria meningitidis MC58 valine--pyruvate transaminase NP_274820.1 1916316 D 122586 CDS NP_274821.1 15677660 903276 complement(1917660..1918496) 1 NC_003112.2 identified by similarity to EGAD:28400; match to protein family HMM PF02231; hypothetical protein 1918496 903276 NMB1824 Neisseria meningitidis MC58 hypothetical protein NP_274821.1 1917660 R 122586 CDS NP_274822.1 15677661 903275 complement(1918941..1919144) 1 NC_003112.2 hypothetical protein 1919144 903275 NMB1825 Neisseria meningitidis MC58 hypothetical protein NP_274822.1 1918941 R 122586 CDS NP_274823.2 566328904 903274 complement(1919122..1919355) 1 NC_003112.2 identified by similarity to EGAD:13382; match to protein family HMM PF01479; hypothetical protein 1919355 903274 NMB1826 Neisseria meningitidis MC58 hypothetical protein NP_274823.2 1919122 R 122586 CDS NP_274824.1 15677663 903273 1919893..1923327 1 NC_003112.2 identified by similarity to EGAD:20624; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594; DNA polymerase III subunit alpha 1923327 dnaE 903273 dnaE Neisseria meningitidis MC58 DNA polymerase III subunit alpha NP_274824.1 1919893 D 122586 CDS NP_274825.1 15677664 903272 complement(1923761..1924693) 1 NC_003112.2 identified by similarity to GP:2738251; match to protein family HMM PF00756; hypothetical protein 1924693 903272 NMB1828 Neisseria meningitidis MC58 hypothetical protein NP_274825.1 1923761 R 122586 CDS NP_274826.1 15677665 903271 complement(1924763..1926889) 1 NC_003112.2 identified by similarity to EGAD:8251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; TonB-dependent receptor 1926889 903271 NMB1829 Neisseria meningitidis MC58 TonB-dependent receptor NP_274826.1 1924763 R 122586 CDS NP_274827.1 15677666 903270 1927037..1927696 1 NC_003112.2 identified by similarity to EGAD:13772; match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 1927696 903270 NMB1830 Neisseria meningitidis MC58 phosphoglycolate phosphatase NP_274827.1 1927037 D 122586 CDS NP_274828.1 15677667 903269 complement(1927784..1928752) 1 NC_003112.2 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1928752 ispH 903269 ispH Neisseria meningitidis MC58 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_274828.1 1927784 R 122586 CDS NP_274829.1 15677668 903268 complement(1928781..1929308) 1 NC_003112.2 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1929308 lspA 903268 lspA Neisseria meningitidis MC58 lipoprotein signal peptidase NP_274829.1 1928781 R 122586 CDS NP_274830.1 15677669 903267 complement(1930584..1933373) 1 NC_003112.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1933373 ileS 903267 ileS Neisseria meningitidis MC58 isoleucyl-tRNA synthetase NP_274830.1 1930584 R 122586 CDS NP_274831.1 15677670 903266 complement(1933515..1934435) 1 NC_003112.2 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1934435 ribF 903266 ribF Neisseria meningitidis MC58 bifunctional riboflavin kinase/FMN adenylyltransferase NP_274831.1 1933515 R 122586 CDS NP_274832.1 15677671 903265 complement(1934963..1936258) 1 NC_003112.2 identified by similarity to EGAD:13660; match to protein family HMM PF00579; match to protein family HMM TIGR00234; tyrosyl-tRNA synthetase 1936258 tyrS 903265 tyrS Neisseria meningitidis MC58 tyrosyl-tRNA synthetase NP_274832.1 1934963 R 122586 CDS NP_274833.1 15677672 903263 complement(1936321..1938192) 1 NC_003112.2 identified by similarity to EGAD:153711; match to protein family HMM PF01757; lipopolysaccharide biosynthesis protein WbpC 1938192 903263 NMB1836 Neisseria meningitidis MC58 lipopolysaccharide biosynthesis protein WbpC NP_274833.1 1936321 R 122586 CDS NP_274834.1 15677673 903262 complement(1938253..1938507) 1 NC_003112.2 hypothetical protein 1938507 903262 NMB1837 Neisseria meningitidis MC58 hypothetical protein NP_274834.1 1938253 R 122586 CDS NP_274835.1 15677674 903261 complement(1938565..1939656) 1 NC_003112.2 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1939656 903261 NMB1838 Neisseria meningitidis MC58 GTP-dependent nucleic acid-binding protein EngD NP_274835.1 1938565 R 122586 CDS NP_274836.1 15677675 903260 complement(1939771..1941447) 1 NC_003112.2 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1941447 fhs 903260 fhs Neisseria meningitidis MC58 formate--tetrahydrofolate ligase NP_274836.1 1939771 R 122586 CDS NP_274837.1 15677676 903259 1941622..1942053 1 NC_003112.2 identified by similarity to EGAD:21387; match to protein family HMM PF00892; hypothetical protein 1942053 903259 NMB1840 Neisseria meningitidis MC58 hypothetical protein NP_274837.1 1941622 D 122586 CDS NP_274838.1 15677677 903258 complement(1942087..1942782) 1 NC_003112.2 identified by similarity to EGAD:48360; match to protein family HMM PF00483; mannose-1-phosphate guanylyltransferase 1942782 903258 NMB1841 Neisseria meningitidis MC58 mannose-1-phosphate guanylyltransferase NP_274838.1 1942087 R 122586 CDS NP_274839.1 15677678 903257 complement(1942798..1943298) 1 NC_003112.2 identified by similarity to GP:3002549; match to protein family HMM PF01613; match to protein family HMM TIGR02296; 4-hydroxyphenylacetate 3-hydroxylase, small subunit 1943298 903257 NMB1842 Neisseria meningitidis MC58 4-hydroxyphenylacetate 3-hydroxylase, small subunit NP_274839.1 1942798 R 122586 CDS NP_274840.1 15677679 903256 complement(1943413..1943853) 1 NC_003112.2 identified by similarity to EGAD:43166; match to protein family HMM PF01047; match to protein family HMM TIGR02337; MarR family transcriptional regulator 1943853 903256 NMB1843 Neisseria meningitidis MC58 MarR family transcriptional regulator NP_274840.1 1943413 R 122586 CDS NP_274841.1 15677680 903255 complement(1943857..1943979) 1 NC_003112.2 hypothetical protein 1943979 903255 NMB1844 Neisseria meningitidis MC58 hypothetical protein NP_274841.1 1943857 R 122586 CDS NP_274842.1 15677681 903254 complement(1944194..1944703) 1 NC_003112.2 identified by similarity to GP:2327006; thioredoxin 1944703 903254 NMB1845 Neisseria meningitidis MC58 thioredoxin NP_274842.1 1944194 R 122586 CDS NP_274843.1 15677682 903252 1945073..1946152 1 NC_003112.2 identified by similarity to EGAD:97951; Mrp/NBP35 family protein 1946152 903252 NMB1846 Neisseria meningitidis MC58 Mrp/NBP35 family protein NP_274843.1 1945073 D 122586 CDS NP_274845.1 15677684 903249 1952630..1953763 1 NC_003112.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1953763 carA 903249 carA Neisseria meningitidis MC58 carbamoyl phosphate synthase small subunit NP_274845.1 1952630 D 122586 CDS NP_274847.1 15677686 903247 1954481..1954741 1 NC_003112.2 hypothetical protein 1954741 903247 NMB1851 Neisseria meningitidis MC58 hypothetical protein NP_274847.1 1954481 D 122586 CDS NP_274848.1 15677687 903246 1954738..1955127 1 NC_003112.2 identified by similarity to EGAD:28177; match to protein family HMM PF04480; hypothetical protein 1955127 903246 NMB1852 Neisseria meningitidis MC58 hypothetical protein NP_274848.1 1954738 D 122586 CDS NP_274849.1 15677688 903245 1955463..1955735 1 NC_003112.2 hypothetical protein 1955735 903245 NMB1853 Neisseria meningitidis MC58 hypothetical protein NP_274849.1 1955463 D 122586 CDS NP_274850.1 15677689 903244 1955809..1956450 1 NC_003112.2 hypothetical protein 1956450 903244 NMB1854 Neisseria meningitidis MC58 hypothetical protein NP_274850.1 1955809 D 122586 CDS NP_274851.1 15677690 903243 1956479..1959694 1 NC_003112.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1959694 carB 903243 carB Neisseria meningitidis MC58 carbamoyl phosphate synthase large subunit NP_274851.1 1956479 D 122586 CDS NP_274852.1 15677691 903242 complement(1959919..1960818) 1 NC_003112.2 identified by similarity to EGAD:15923; match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 1960818 903242 NMB1856 Neisseria meningitidis MC58 LysR family transcriptional regulator NP_274852.1 1959919 R 122586 CDS NP_274853.1 15677692 903241 1961057..1961635 1 NC_003112.2 identified by similarity to EGAD:90558; match to protein family HMM PF02525; modulator of drug activity B 1961635 mdaB 903241 mdaB Neisseria meningitidis MC58 modulator of drug activity B NP_274853.1 1961057 D 122586 CDS NP_274854.1 15677693 903240 complement(1961632..1962018) 1 NC_003112.2 hypothetical protein 1962018 903240 NMB1858 Neisseria meningitidis MC58 hypothetical protein NP_274854.1 1961632 R 122586 CDS NP_274855.1 15677694 903239 complement(1962109..1963149) 1 NC_003112.2 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1963149 queA 903239 queA Neisseria meningitidis MC58 S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_274855.1 1962109 R 122586 CDS NP_274856.1 15677695 903238 1963505..1963960 1 NC_003112.2 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1963960 accB 903238 accB Neisseria meningitidis MC58 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_274856.1 1963505 D 122586 CDS NP_274857.1 15677696 904327 1964072..1965433 1 NC_003112.2 identified by similarity to EGAD:27995; match to protein family HMM PF00289; match to protein family HMM PF02785; match to protein family HMM PF02786; match to protein family HMM TIGR00514; acetyl-CoA carboxylase, biotin carboxylase 1965433 accC 904327 accC Neisseria meningitidis MC58 acetyl-CoA carboxylase, biotin carboxylase NP_274857.1 1964072 D 122586 CDS NP_274858.1 15677697 904326 1965694..1966581 1 NC_003112.2 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1966581 prmA 904326 prmA Neisseria meningitidis MC58 50S ribosomal protein L11 methyltransferase NP_274858.1 1965694 D 122586 CDS NP_274859.1 15677698 904325 1966599..1967162 1 NC_003112.2 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1967162 orn 904325 orn Neisseria meningitidis MC58 oligoribonuclease NP_274859.1 1966599 D 122586 CDS NP_274860.1 15677699 904324 complement(1967566..1968849) 1 NC_003112.2 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1968849 hemL 904324 hemL Neisseria meningitidis MC58 glutamate-1-semialdehyde aminotransferase NP_274860.1 1967566 R 122586 CDS NP_274862.1 15677701 904322 1969634..1970962 1 NC_003112.2 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1970962 904322 NMB1866 Neisseria meningitidis MC58 (dimethylallyl)adenosine tRNA methylthiotransferase NP_274862.1 1969634 D 122586 CDS NP_274863.1 15677702 904321 complement(1971047..1972960) 1 NC_003112.2 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1972960 dxs 904321 dxs Neisseria meningitidis MC58 1-deoxy-D-xylulose-5-phosphate synthase NP_274863.1 1971047 R 122586 CDS NP_274864.1 15677703 904320 complement(1973045..1973950) 1 NC_003112.2 identified by similarity to GP:2625019; match to protein family HMM PF00589; match to protein family HMM PF02899; match to protein family HMM TIGR02224; integrase/recombinase XerC 1973950 xerC 904320 xerC Neisseria meningitidis MC58 integrase/recombinase XerC NP_274864.1 1973045 R 122586 CDS NP_274865.1 15677704 904319 1974134..1975198 1 NC_003112.2 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1975198 cbbA 904319 cbbA Neisseria meningitidis MC58 fructose-1,6-bisphosphate aldolase NP_274865.1 1974134 D 122586 CDS NP_274866.1 15677705 904318 1975218..1976180 1 NC_003112.2 hypothetical protein 1976180 904318 NMB1870 Neisseria meningitidis MC58 hypothetical protein NP_274866.1 1975218 D 122586 CDS NP_274867.1 15677706 904317 1976327..1977004 1 NC_003112.2 identified by similarity to EGAD:90678; match to protein family HMM PF00814; hypothetical protein 1977004 904317 NMB1871 Neisseria meningitidis MC58 hypothetical protein NP_274867.1 1976327 D 122586 CDS NP_274868.1 15677707 904316 1977001..1977441 1 NC_003112.2 identified by similarity to EGAD:8763; match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 1977441 904316 NMB1872 Neisseria meningitidis MC58 ribosomal-protein-alanine acetyltransferase NP_274868.1 1977001 D 122586 CDS NP_274869.1 15677708 904315 1977435..1978172 1 NC_003112.2 identified by similarity to EGAD:157119; DNA polymerase 1978172 904315 NMB1873 Neisseria meningitidis MC58 DNA polymerase NP_274869.1 1977435 D 122586 CDS NP_274870.1 15677709 904314 1978234..1978875 1 NC_003112.2 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1978875 pyrE 904314 pyrE Neisseria meningitidis MC58 orotate phosphoribosyltransferase NP_274870.1 1978234 D 122586 CDS NP_274871.1 15677710 904313 1978949..1979383 1 NC_003112.2 hypothetical protein 1979383 904313 NMB1875 Neisseria meningitidis MC58 hypothetical protein NP_274871.1 1978949 D 122586 CDS NP_274872.1 15677711 904312 1979380..1980690 1 NC_003112.2 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 1980690 argA 904312 argA Neisseria meningitidis MC58 N-acetylglutamate synthase NP_274872.1 1979380 D 122586 CDS NP_274873.1 15677712 904309 1980891..1982906 1 NC_003112.2 identified by similarity to EGAD:132306; match to protein family HMM PF00326; match to protein family HMM PF02897; prolyl oligopeptidase 1982906 904309 NMB1877 Neisseria meningitidis MC58 prolyl oligopeptidase NP_274873.1 1980891 D 122586 CDS NP_274876.1 15677715 904303 1984213..1985178 1 NC_003112.2 identified by similarity to EGAD:108974; match to protein family HMM PF01497; ABC transporter substrate-binding protein 1985178 904303 NMB1880 Neisseria meningitidis MC58 ABC transporter substrate-binding protein NP_274876.1 1984213 D 122586 CDS NP_274877.1 15677716 904300 1985735..1986058 1 NC_003112.2 identified by similarity to EGAD:108081; match to protein family HMM PF07883; hypothetical protein 1986058 904300 NMB1881 Neisseria meningitidis MC58 hypothetical protein NP_274877.1 1985735 D 122586 CDS NP_274878.1 15677717 904299 1986172..1988349 1 NC_003112.2 identified by similarity to EGAD:8251; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; TonB-dependent receptor 1988349 904299 NMB1882 Neisseria meningitidis MC58 TonB-dependent receptor NP_274878.1 1986172 D 122586 CDS NP_274879.1 15677718 904298 complement(1988478..1988768) 1 NC_003112.2 hypothetical protein 1988768 904298 NMB1883 Neisseria meningitidis MC58 hypothetical protein NP_274879.1 1988478 R 122586 CDS NP_274880.1 15677719 904296 complement(1988765..1989088) 1 NC_003112.2 identified by similarity to EGAD:156337; match to protein family HMM PF00581; hypothetical protein 1989088 904296 NMB1884 Neisseria meningitidis MC58 hypothetical protein NP_274880.1 1988765 R 122586 CDS NP_274881.1 15677720 904295 complement(1989168..1989824) 1 NC_003112.2 identified by similarity to EGAD:23058; match to protein family HMM PF01135; protein-L-isoaspartate O-methyltransferase 1989824 pcm 904295 pcm Neisseria meningitidis MC58 protein-L-isoaspartate O-methyltransferase NP_274881.1 1989168 R 122586 CDS NP_274882.1 15677721 904292 complement(1989927..1990430) 1 NC_003112.2 identified by similarity to EGAD:91612; match to protein family HMM PF01590; hypothetical protein 1990430 904292 NMB1886 Neisseria meningitidis MC58 hypothetical protein NP_274882.1 1989927 R 122586 CDS NP_274883.1 15677722 904291 1990609..1991382 1 NC_003112.2 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1991382 tpiA 904291 tpiA Neisseria meningitidis MC58 triosephosphate isomerase NP_274883.1 1990609 D 122586 CDS NP_274884.1 15677723 904290 1991389..1991739 1 NC_003112.2 identified by similarity to EGAD:23175; match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 1991739 secG 904290 secG Neisseria meningitidis MC58 preprotein translocase subunit SecG NP_274884.1 1991389 D 122586 CDS NP_274885.1 15677724 904288 1992527..1992619 1 NC_003112.2 hypothetical protein 1992619 904288 NMB1889 Neisseria meningitidis MC58 hypothetical protein NP_274885.1 1992527 D 122586 CDS NP_274886.1 15677725 904287 1992750..1993118 1 NC_003112.2 identified by similarity to EGAD:19883; match to protein family HMM PF06296; hypothetical protein 1993118 904287 NMB1890 Neisseria meningitidis MC58 hypothetical protein NP_274886.1 1992750 D 122586 CDS NP_274887.1 15677726 904286 1993115..1993426 1 NC_003112.2 identified by similarity to EGAD:24379; match to protein family HMM PF01381; helix-turn-helix family protein 1993426 904286 NMB1891 Neisseria meningitidis MC58 helix-turn-helix family protein NP_274887.1 1993115 D 122586 CDS NP_274888.1 15677727 904285 1993536..1993748 1 NC_003112.2 hypothetical protein 1993748 904285 NMB1892 Neisseria meningitidis MC58 hypothetical protein NP_274888.1 1993536 D 122586 CDS YP_008920726.1 566328940 904283 complement(1993809..1994690) 1 NC_003112.2 hypothetical protein 1994690 904283 NMB1893 Neisseria meningitidis MC58 hypothetical protein YP_008920726.1 1993809 R 122586 CDS NP_274889.1 15678017 903121 complement(1994761..1994892) 1 NC_003112.2 identified by similarity to EGAD:108383; leucyl-tRNA synthetase 1994892 903121 NMB1894 Neisseria meningitidis MC58 leucyl-tRNA synthetase NP_274889.1 1994761 R 122586 CDS NP_274890.1 15678018 903119 complement(1994885..1995028) 1 NC_003112.2 identified by similarity to EGAD:28856; DNA adenine methylase, truncation 1995028 903119 NMB1895 Neisseria meningitidis MC58 DNA adenine methylase, truncation NP_274890.1 1994885 R 122586 CDS NP_274891.1 15677728 904280 complement(1995012..1995815) 1 NC_003112.2 identified by similarity to EGAD:6380; match to protein family HMM PF06044; type II restriction enzyme DpnI 1995815 dpnC 904280 dpnC Neisseria meningitidis MC58 type II restriction enzyme DpnI NP_274891.1 1995012 R 122586 CDS NP_274892.1 15677729 904274 complement(1995949..1998579) 1 NC_003112.2 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1998579 leuS 904274 leuS Neisseria meningitidis MC58 leucyl-tRNA synthetase NP_274892.1 1995949 R 122586 CDS NP_274893.1 15677730 904273 1998849..1999364 1 NC_003112.2 identified by similarity to EGAD:40759; match to protein family HMM PF04355; lipoprotein 1999364 mlp 904273 mlp Neisseria meningitidis MC58 lipoprotein NP_274893.1 1998849 D 122586 CDS NP_274894.1 15677731 904272 1999371..1999814 1 NC_003112.2 hypothetical protein 1999814 904272 NMB1899 Neisseria meningitidis MC58 hypothetical protein NP_274894.1 1999371 D 122586 CDS NP_274895.1 15677732 904271 1999890..2002040 1 NC_003112.2 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2002040 ppk 904271 ppk Neisseria meningitidis MC58 polyphosphate kinase NP_274895.1 1999890 D 122586 CDS NP_274896.1 15677733 904268 complement(2003051..2004154) 1 NC_003112.2 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2004154 dnaN 904268 dnaN Neisseria meningitidis MC58 DNA polymerase III subunit beta NP_274896.1 2003051 R 122586 CDS NP_274897.1 15677734 904267 complement(2004389..2005945) 1 NC_003112.2 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 2005945 dnaA 904267 dnaA Neisseria meningitidis MC58 chromosomal replication initiation protein NP_274897.1 2004389 R 122586 CDS NP_274898.1 15677735 904264 2006237..2006371 1 NC_003112.2 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 2006371 rpmH 904264 rpmH Neisseria meningitidis MC58 50S ribosomal protein L34 NP_274898.1 2006237 D 122586 CDS NP_274899.1 15677736 904262 2006374..2006739 1 NC_003112.2 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2006739 rnpA 904262 rnpA Neisseria meningitidis MC58 ribonuclease P NP_274899.1 2006374 D 122586 CDS NP_274900.1 15677737 904261 2006804..2007025 1 NC_003112.2 identified by similarity to EGAD:108432; match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein 2007025 904261 NMB1906 Neisseria meningitidis MC58 hypothetical protein NP_274900.1 2006804 D 122586 CDS NP_274901.1 15677738 904258 2007197..2008834 1 NC_003112.2 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 2008834 yidC 904258 yidC Neisseria meningitidis MC58 inner membrane protein translocase component YidC NP_274901.1 2007197 D 122586 CDS NP_274902.1 15677739 904257 complement(2008915..2009640) 1 NC_003112.2 identified by similarity to EGAD:47901; match to protein family HMM PF00590; hypothetical protein 2009640 904257 NMB1908 Neisseria meningitidis MC58 hypothetical protein NP_274902.1 2008915 R 122586 CDS NP_274903.1 15677740 904255 complement(2009687..2010277) 1 NC_003112.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2010277 maf 904255 maf Neisseria meningitidis MC58 Maf-like protein NP_274903.1 2009687 R 122586 CDS NP_274904.1 15677741 904254 2010425..2010928 1 NC_003112.2 identified by similarity to EGAD:19555; match to protein family HMM PF02620; hypothetical protein 2010928 904254 NMB1910 Neisseria meningitidis MC58 hypothetical protein NP_274904.1 2010425 D 122586 CDS NP_274905.1 15677742 904253 2010962..2011141 1 NC_003112.2 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2011141 rpmF 904253 rpmF Neisseria meningitidis MC58 50S ribosomal protein L32 NP_274905.1 2010962 D 122586 CDS NP_274906.1 15677743 904252 2011316..2011843 1 NC_003112.2 identified by similarity to EGAD:133045; match to protein family HMM PF00156; hypothetical protein 2011843 904252 NMB1912 Neisseria meningitidis MC58 hypothetical protein NP_274906.1 2011316 D 122586 CDS NP_274907.1 15677744 904250 2011932..2012987 1 NC_003112.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 2012987 plsX 904250 plsX Neisseria meningitidis MC58 glycerol-3-phosphate acyltransferase PlsX NP_274907.1 2011932 D 122586 CDS NP_274908.1 15677745 904249 2013123..2013374 1 NC_003112.2 hypothetical protein 2013374 904249 NMB1914 Neisseria meningitidis MC58 hypothetical protein NP_274908.1 2013123 D 122586 CDS NP_274909.1 15677746 904247 2013401..2013790 1 NC_003112.2 hypothetical protein 2013790 904247 NMB1915 Neisseria meningitidis MC58 hypothetical protein NP_274909.1 2013401 D 122586 CDS NP_274910.1 15677747 904246 2013972..2014934 1 NC_003112.2 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 2014934 fabH 904246 fabH Neisseria meningitidis MC58 3-oxoacyl-ACP synthase NP_274910.1 2013972 D 122586 CDS NP_274911.1 15677748 904245 2014981..2015388 1 NC_003112.2 identified by similarity to EGAD:107750; match to protein family HMM PF06961; hypothetical protein 2015388 904245 NMB1917 Neisseria meningitidis MC58 hypothetical protein NP_274911.1 2014981 D 122586 CDS NP_274912.1 15677749 904244 2015482..2016408 1 NC_003112.2 identified by similarity to EGAD:22444; match to protein family HMM PF00698; match to protein family HMM TIGR00128; ACP S-malonyltransferase 2016408 fabD 904244 fabD Neisseria meningitidis MC58 ACP S-malonyltransferase NP_274912.1 2015482 D 122586 CDS NP_274913.1 15677750 904243 2016546..2018411 1 NC_003112.2 identified by similarity to EGAD:6816; match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM TIGR02203; ABC transporter ATP-binding protein 2018411 904243 NMB1919 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274913.1 2016546 D 122586 CDS NP_274914.1 15677751 904234 2018511..2020076 1 NC_003112.2 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2020076 guaA 904234 guaA Neisseria meningitidis MC58 GMP synthase NP_274914.1 2018511 D 122586 CDS NP_274915.1 15677752 904233 2020138..2020884 1 NC_003112.2 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2020884 fabG 904233 fabG Neisseria meningitidis MC58 3-ketoacyl-ACP reductase NP_274915.1 2020138 D 122586 CDS NP_274918.1 15677754 904231 complement(2022019..2022714) 1 NC_003112.2 identified by similarity to GP:1658411; match to protein family HMM PF00459; inositol monophosphatase 2022714 904231 NMB1924 Neisseria meningitidis MC58 inositol monophosphatase NP_274918.1 2022019 R 122586 CDS NP_274919.1 15677755 904230 2022917..2023642 1 NC_003112.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 2023642 904230 NMB1925 Neisseria meningitidis MC58 16S ribosomal RNA methyltransferase RsmE NP_274919.1 2022917 D 122586 CDS NP_274920.1 15677756 904229 complement(2024879..2025721) 1 NC_003112.2 identified by similarity to EGAD:40826; match to protein family HMM PF01755; lacto-N-neotetraose biosynthesis glycosyl transferase LgtE 2025721 lgtE 904229 lgtE Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl transferase LgtE NP_274920.1 2024879 R 122586 CDS NP_274921.1 15677757 904228 complement(2025763..2025858) 1 NC_003112.2 identified by similarity to EGAD:40776; lacto-N-neotetraose biosynthesis glycosyl transferase-like protein 2025858 904228 NMB1927 Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl transferase-like protein NP_274921.1 2025763 R 122586 CDS NP_274922.1 15677758 904227 complement(2025870..2026697) 1 NC_003112.2 identified by similarity to EGAD:40825; match to protein family HMM PF01755; lacto-N-neotetraose biosynthesis glycosyl transferase LgtB 2026697 lgtB 904227 lgtB Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl transferase LgtB NP_274922.1 2025870 R 122586 CDS NP_274923.1 15677759 904226 complement(2026739..2027788) 1 NC_003112.2 identified by similarity to EGAD:40824; match to protein family HMM PF00535; lacto-N-neotetraose biosynthesis glycosyl transferase 2027788 lgtA 904226 lgtA Neisseria meningitidis MC58 lacto-N-neotetraose biosynthesis glycosyl transferase NP_274923.1 2026739 R 122586 CDS NP_274924.1 15677760 904225 complement(2027805..2029868) 1 NC_003112.2 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 2029868 glyS 904225 glyS Neisseria meningitidis MC58 glycyl-tRNA synthetase subunit beta NP_274924.1 2027805 R 122586 CDS NP_274926.1 15677762 904222 complement(2030374..2031279) 1 NC_003112.2 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 2031279 glyQ 904222 glyQ Neisseria meningitidis MC58 glycyl-tRNA synthetase subunit alpha NP_274926.1 2030374 R 122586 CDS NP_274927.1 15677763 904221 complement(2031684..2032106) 1 NC_003112.2 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 2032106 atpC 904221 atpC Neisseria meningitidis MC58 ATP synthase F0F1 subunit epsilon NP_274927.1 2031684 R 122586 CDS NP_274928.1 15677764 904218 complement(2032117..2033514) 1 NC_003112.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 2033514 atpD 904218 atpD Neisseria meningitidis MC58 ATP synthase F0F1 subunit beta NP_274928.1 2032117 R 122586 CDS NP_274929.1 15677765 904217 complement(2033552..2034427) 1 NC_003112.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 2034427 atpG 904217 atpG Neisseria meningitidis MC58 ATP synthase F0F1 subunit gamma NP_274929.1 2033552 R 122586 CDS NP_274930.1 15677766 904216 complement(2034452..2035999) 1 NC_003112.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 2035999 atpA 904216 atpA Neisseria meningitidis MC58 ATP synthase F0F1 subunit alpha NP_274930.1 2034452 R 122586 CDS NP_274931.1 15677767 904215 complement(2036010..2036543) 1 NC_003112.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 2036543 atpH 904215 atpH Neisseria meningitidis MC58 ATP synthase F0F1 subunit delta NP_274931.1 2036010 R 122586 CDS NP_274932.1 15677768 904214 complement(2036548..2037018) 1 NC_003112.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 2037018 atpF 904214 atpF Neisseria meningitidis MC58 ATP synthase F0F1 subunit B NP_274932.1 2036548 R 122586 CDS NP_274933.1 15677769 904213 complement(2037089..2037325) 1 NC_003112.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 2037325 atpE 904213 atpE Neisseria meningitidis MC58 ATP synthase F0F1 subunit C NP_274933.1 2037089 R 122586 CDS NP_274934.1 15677770 904211 complement(2037382..2038248) 1 NC_003112.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 2038248 atpB 904211 atpB Neisseria meningitidis MC58 ATP synthase F0F1 subunit A NP_274934.1 2037382 R 122586 CDS NP_274935.1 15677771 904210 complement(2038238..2038591) 1 NC_003112.2 hypothetical protein 2038591 904210 NMB1941 Neisseria meningitidis MC58 hypothetical protein NP_274935.1 2038238 R 122586 CDS NP_274938.1 15677774 904207 complement(2039433..2040293) 1 NC_003112.2 identified by similarity to EGAD:137275; match to protein family HMM PF02195; match to protein family HMM TIGR00180; ParB family protein 2040293 904207 NMB1944 Neisseria meningitidis MC58 ParB family protein NP_274938.1 2039433 R 122586 CDS NP_274939.1 15677775 904206 2040448..2041020 1 NC_003112.2 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; aromatic acid decarboxylase 2041020 ubiX 904206 ubiX Neisseria meningitidis MC58 aromatic acid decarboxylase NP_274939.1 2040448 D 122586 CDS NP_274940.1 15677776 904205 complement(2041082..2041945) 1 NC_003112.2 identified by similarity to EGAD:30554; match to protein family HMM PF03180; outer membrane lipoprotein 2041945 904205 NMB1946 Neisseria meningitidis MC58 outer membrane lipoprotein NP_274940.1 2041082 R 122586 CDS NP_274941.1 15677777 904203 complement(2042104..2042790) 1 NC_003112.2 identified by similarity to GP:303561; match to protein family HMM PF00528; ABC transporter permease 2042790 904203 NMB1947 Neisseria meningitidis MC58 ABC transporter permease NP_274941.1 2042104 R 122586 CDS NP_274942.1 15677778 904202 complement(2042792..2043529) 1 NC_003112.2 identified by similarity to GP:1208966; match to protein family HMM PF00005; ABC transporter ATP-binding protein 2043529 904202 NMB1948 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274942.1 2042792 R 122586 CDS NP_274943.1 15677779 904201 2044059..2045909 1 NC_003112.2 identified by similarity to EGAD:23218; match to protein family HMM PF01464; soluble lytic murein transglycosylase 2045909 904201 NMB1949 Neisseria meningitidis MC58 soluble lytic murein transglycosylase NP_274943.1 2044059 D 122586 CDS NP_274944.1 15677780 904200 2046198..2046410 1 NC_003112.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 2046410 rpsU 904200 rpsU Neisseria meningitidis MC58 30S ribosomal protein S21 NP_274944.1 2046198 D 122586 CDS NP_274945.1 15677781 904199 2046446..2046988 1 NC_003112.2 identified by similarity to EGAD:149888; match to protein family HMM PF02637; hypothetical protein 2046988 904199 NMB1951 Neisseria meningitidis MC58 hypothetical protein NP_274945.1 2046446 D 122586 CDS NP_274946.1 15677782 904198 complement(2047187..2047579) 1 NC_003112.2 identified by similarity to EGAD:140928; match to protein family HMM PF04386; ClpXP protease specificity-enhancing factor 2047579 sspB 904198 sspB Neisseria meningitidis MC58 ClpXP protease specificity-enhancing factor NP_274946.1 2047187 R 122586 CDS NP_274947.1 15677783 904197 complement(2047651..2048256) 1 NC_003112.2 identified by similarity to EGAD:140927; match to protein family HMM PF00043; match to protein family HMM PF02798; stringent starvation protein A 2048256 sspA 904197 sspA Neisseria meningitidis MC58 stringent starvation protein A NP_274947.1 2047651 R 122586 CDS NP_274948.1 15677784 904196 complement(2048526..2050187) 1 NC_003112.2 hypothetical protein 2050187 904196 NMB1954 Neisseria meningitidis MC58 hypothetical protein NP_274948.1 2048526 R 122586 CDS NP_274949.1 15677785 904195 complement(2050348..2050974) 1 NC_003112.2 identified by similarity to GP:1916729; match to protein family HMM PF03596; match to protein family HMM TIGR00779; cadmium resistance protein 2050974 904195 NMB1955 Neisseria meningitidis MC58 cadmium resistance protein NP_274949.1 2050348 R 122586 CDS NP_274950.1 15677786 904194 complement(2051277..2051492) 1 NC_003112.2 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 2051492 rpmE 904194 rpmE Neisseria meningitidis MC58 50S ribosomal protein L31 NP_274950.1 2051277 R 122586 CDS NP_274952.1 15677788 904192 complement(2052311..2052811) 1 NC_003112.2 identified by similarity to EGAD:109028; thioredoxin 2052811 904192 NMB1958 Neisseria meningitidis MC58 thioredoxin NP_274952.1 2052311 R 122586 CDS NP_274953.1 15677789 904191 complement(2052808..2053191) 1 NC_003112.2 identified by similarity to EGAD:91226; match to protein family HMM PF03061; match to protein family HMM TIGR00051; hypothetical protein 2053191 904191 NMB1959 Neisseria meningitidis MC58 hypothetical protein NP_274953.1 2052808 R 122586 CDS NP_274954.1 15677790 904190 complement(2053191..2053673) 1 NC_003112.2 hypothetical protein 2053673 904190 NMB1960 Neisseria meningitidis MC58 hypothetical protein NP_274954.1 2053191 R 122586 CDS NP_274955.1 15677791 904189 complement(2053678..2054505) 1 NC_003112.2 identified by similarity to EGAD:90986; match to protein family HMM PF04333; VacJ-like protein 2054505 904189 NMB1961 Neisseria meningitidis MC58 VacJ-like protein NP_274955.1 2053678 R 122586 CDS NP_274956.1 15677792 904187 complement(2054502..2054780) 1 NC_003112.2 hypothetical protein 2054780 904187 NMB1962 Neisseria meningitidis MC58 hypothetical protein NP_274956.1 2054502 R 122586 CDS NP_274957.1 15677793 904186 complement(2054831..2055421) 1 NC_003112.2 identified by similarity to EGAD:163193; match to protein family HMM PF05494; hypothetical protein 2055421 904186 NMB1963 Neisseria meningitidis MC58 hypothetical protein NP_274957.1 2054831 R 122586 CDS NP_274958.1 15677794 904185 complement(2055458..2055952) 1 NC_003112.2 identified by similarity to EGAD:28106; match to protein family HMM PF02470; hypothetical protein 2055952 904185 NMB1964 Neisseria meningitidis MC58 hypothetical protein NP_274958.1 2055458 R 122586 CDS NP_274959.1 15677795 904180 complement(2056003..2056779) 1 NC_003112.2 identified by similarity to EGAD:28097; match to protein family HMM PF02405; match to protein family HMM TIGR00056; hypothetical protein 2056779 904180 NMB1965 Neisseria meningitidis MC58 hypothetical protein NP_274959.1 2056003 R 122586 CDS NP_274960.1 15677796 904178 complement(2056827..2057627) 1 NC_003112.2 identified by similarity to EGAD:28098; match to protein family HMM PF00005; ABC transporter ATP-binding protein 2057627 904178 NMB1966 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_274960.1 2056827 R 122586 CDS NP_274961.1 15677797 904175 2057800..2058717 1 NC_003112.2 identified by similarity to EGAD:49771; match to protein family HMM PF00165; AraC family transcriptional regulator 2058717 904175 NMB1967 Neisseria meningitidis MC58 AraC family transcriptional regulator NP_274961.1 2057800 D 122586 CDS NP_274962.1 15677798 904174 2058977..2060419 1 NC_003112.2 NAD-linked; aldehyde dehydrogenase 2060419 aldA 904174 aldA Neisseria meningitidis MC58 aldehyde dehydrogenase NP_274962.1 2058977 D 122586 CDS NP_274963.1 15677799 904173 2061453..2064701 1 NC_003112.2 identified by similarity to EGAD:23198; match to protein family HMM PF00082; match to protein family HMM PF03797; match to protein family HMM TIGR01414; serotype-1-specific antigen 2064701 904173 NMB1969 Neisseria meningitidis MC58 serotype-1-specific antigen NP_274963.1 2061453 D 122586 CDS NP_274964.1 15677800 904171 2065733..2067514 1 NC_003112.2 identified by similarity to EGAD:90483; match to protein family HMM PF00425; para-aminobenzoate synthetase component I/4-amino-4-deoxychorismate lyase 2067514 904171 NMB1970 Neisseria meningitidis MC58 para-aminobenzoate synthetase component I/4-amino-4-deoxychorismate lyase NP_274964.1 2065733 D 122586 CDS NP_274965.1 15677801 904170 complement(2067573..2069090) 1 NC_003112.2 identified by similarity to GP:3523136; match to protein family HMM PF04575; hypothetical protein 2069090 904170 NMB1971 Neisseria meningitidis MC58 hypothetical protein NP_274965.1 2067573 R 122586 CDS NP_274966.1 15677802 904169 complement(2069786..2071420) 1 NC_003112.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 2071420 groEL 904169 groEL Neisseria meningitidis MC58 molecular chaperone GroEL NP_274966.1 2069786 R 122586 CDS NP_274967.1 15677803 904167 complement(2071513..2071803) 1 NC_003112.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 2071803 groES 904167 groES Neisseria meningitidis MC58 co-chaperonin GroES NP_274967.1 2071513 R 122586 CDS NP_274968.1 15677804 904164 2072896..2074431 1 NC_003112.2 identified by similarity to EGAD:29502; match to protein family HMM PF00209; sodium- and chloride-dependent transporter 2074431 904164 NMB1975 Neisseria meningitidis MC58 sodium- and chloride-dependent transporter NP_274968.1 2072896 D 122586 CDS NP_274969.1 15677805 904163 complement(2074556..2075800) 1 NC_003112.2 identified by similarity to EGAD:6236; match to protein family HMM PF00278; match to protein family HMM PF02784; match to protein family HMM TIGR01048; diaminopimelate decarboxylase 2075800 lysA 904163 lysA Neisseria meningitidis MC58 diaminopimelate decarboxylase NP_274969.1 2074556 R 122586 CDS NP_274970.1 15677806 904162 complement(2075811..2075981) 1 NC_003112.2 hypothetical protein 2075981 904162 NMB1977 Neisseria meningitidis MC58 hypothetical protein NP_274970.1 2075811 R 122586 CDS NP_274971.1 15677807 904161 2076052..2076375 1 NC_003112.2 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 2076375 cyaY 904161 cyaY Neisseria meningitidis MC58 frataxin-like protein NP_274971.1 2076052 D 122586 CDS NP_274972.1 15677808 904160 2076402..2077418 1 NC_003112.2 identified by similarity to EGAD:28633; match to protein family HMM PF03601; match to protein family HMM TIGR00698; hypothetical protein 2077418 904160 NMB1979 Neisseria meningitidis MC58 hypothetical protein NP_274972.1 2076402 D 122586 CDS NP_274973.1 15677809 904158 2077444..2077863 1 NC_003112.2 identified by similarity to EGAD:29414; hypothetical protein 2077863 904158 NMB1980 Neisseria meningitidis MC58 hypothetical protein NP_274973.1 2077444 D 122586 CDS NP_274974.1 15677810 904156 2077885..2078391 1 NC_003112.2 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2078391 904156 NMB1981 Neisseria meningitidis MC58 S-ribosylhomocysteinase NP_274974.1 2077885 D 122586 CDS NP_274975.1 15677811 904155 2078537..2081353 1 NC_003112.2 identified by similarity to EGAD:23009; match to protein family HMM PF00476; match to protein family HMM PF01367; match to protein family HMM PF01612; match to protein family HMM PF02739; match to protein family HMM TIGR00593; DNA polymerase I 2081353 polA 904155 polA Neisseria meningitidis MC58 DNA polymerase I NP_274975.1 2078537 D 122586 CDS NP_274976.1 15677812 904154 2082699..2083370 1 NC_003112.2 hypothetical protein 2083370 904154 NMB1983 Neisseria meningitidis MC58 hypothetical protein NP_274976.1 2082699 D 122586 CDS NP_274977.1 15677813 904147 complement(2084859..2089232) 1 NC_003112.2 identified by similarity to GP:1408569; match to protein family HMM PF02395; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; adhesion and penetration protein 2089232 hap 904147 hap Neisseria meningitidis MC58 adhesion and penetration protein NP_274977.1 2084859 R 122586 CDS NP_274978.1 15677814 904146 complement(2089366..2089797) 1 NC_003112.2 hypothetical protein 2089797 904146 NMB1986 Neisseria meningitidis MC58 hypothetical protein NP_274978.1 2089366 R 122586 CDS NP_274979.1 15677815 904145 2090082..2091428 1 NC_003112.2 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 2091428 trmE 904145 trmE Neisseria meningitidis MC58 tRNA modification GTPase TrmE NP_274979.1 2090082 D 122586 CDS NP_274980.1 15677816 904143 2092652..2094796 1 NC_003112.2 identified by similarity to EGAD:133971; match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783; iron-regulated outer membrane protein FrpB 2094796 frpB 904143 frpB Neisseria meningitidis MC58 iron-regulated outer membrane protein FrpB NP_274980.1 2092652 D 122586 CDS NP_274981.1 15677817 904142 2095513..2096478 1 NC_003112.2 identified by similarity to EGAD:108974; match to protein family HMM PF01497; iron ABC transporter substrate-binding protein 2096478 904142 NMB1989 Neisseria meningitidis MC58 iron ABC transporter substrate-binding protein NP_274981.1 2095513 D 122586 CDS NP_274982.1 15677818 904141 2096642..2097610 1 NC_003112.2 identified by similarity to EGAD:108968; match to protein family HMM PF01032; iron ABC transporter permease 2097610 904141 NMB1990 Neisseria meningitidis MC58 iron ABC transporter permease NP_274982.1 2096642 D 122586 CDS NP_274983.1 15677819 904139 2097600..2098574 1 NC_003112.2 identified by similarity to EGAD:108970; match to protein family HMM PF01032; iron(III) ABC transporter permease 2098574 904139 NMB1991 Neisseria meningitidis MC58 iron(III) ABC transporter permease NP_274983.1 2097600 D 122586 CDS NP_274984.1 15677820 904137 2098618..2099244 1 NC_003112.2 hypothetical protein 2099244 904137 NMB1992 Neisseria meningitidis MC58 hypothetical protein NP_274984.1 2098618 D 122586 CDS NP_274985.1 15677821 904135 2099327..2100085 1 NC_003112.2 identified by similarity to EGAD:108972; match to protein family HMM PF00005; iron(III) ABC transporter ATP-binding protein 2100085 904135 NMB1993 Neisseria meningitidis MC58 iron(III) ABC transporter ATP-binding protein NP_274985.1 2099327 D 122586 CDS NP_274986.1 15677822 904134 2100383..2101477 1 NC_003112.2 identified by similarity to GP:2735093; match to protein family HMM PF03895; adhesin/invasin 2101477 904134 NMB1994 Neisseria meningitidis MC58 adhesin/invasin NP_274986.1 2100383 D 122586 CDS NP_274987.1 15677823 904133 complement(2101543..2101881) 1 NC_003112.2 identified by similarity to EGAD:7369; match to protein family HMM PF00543; nitrogen regulatory protein P-II 1 2101881 glnB 904133 glnB Neisseria meningitidis MC58 nitrogen regulatory protein P-II 1 NP_274987.1 2101543 R 122586 CDS NP_274988.1 15677824 904131 2102032..2105994 1 NC_003112.2 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2105994 purL 904131 purL Neisseria meningitidis MC58 phosphoribosylformylglycinamidine synthase NP_274988.1 2102032 D 122586 CDS NP_274989.1 15677825 904130 2106089..2106847 1 NC_003112.2 identified by similarity to EGAD:35929; match to protein family HMM PF00753; hydroxyacylglutathione hydrolase 2106847 gloB 904130 gloB Neisseria meningitidis MC58 hydroxyacylglutathione hydrolase NP_274989.1 2106089 D 122586 CDS NP_274990.1 15677826 904129 2107161..2111456 1 NC_003112.2 identified by similarity to GP:1408569; match to protein family HMM PF02395; match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414; serine-type peptidase 2111456 904129 NMB1998 Neisseria meningitidis MC58 serine-type peptidase NP_274990.1 2107161 D 122586 CDS NP_274991.1 15677827 904127 2111688..2113142 1 NC_003112.2 identified by similarity to EGAD:107500; match to protein family HMM PF00571; match to protein family HMM PF01769; match to protein family HMM PF03448; match to protein family HMM TIGR00400; magnesium transporter 2113142 mgtE 904127 mgtE Neisseria meningitidis MC58 magnesium transporter NP_274991.1 2111688 D 122586 CDS NP_274992.1 15677828 904125 complement(2113228..2114136) 1 NC_003112.2 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2114136 hslO 904125 hslO Neisseria meningitidis MC58 Hsp33-like chaperonin NP_274992.1 2113228 R 122586 CDS NP_274993.1 15677829 904124 2114381..2115136 1 NC_003112.2 identified by similarity to EGAD:91561; match to protein family HMM PF00877; hypothetical protein 2115136 904124 NMB2001 Neisseria meningitidis MC58 hypothetical protein NP_274993.1 2114381 D 122586 CDS NP_274994.1 15677830 904123 2115155..2115373 1 NC_003112.2 hypothetical protein 2115373 904123 NMB2002 Neisseria meningitidis MC58 hypothetical protein NP_274994.1 2115155 D 122586 CDS NP_274995.1 15677831 904119 2115518..2115865 1 NC_003112.2 identified by similarity to EGAD:9831; match to protein family HMM PF03788; hypothetical protein 2115865 904119 NMB2003 Neisseria meningitidis MC58 hypothetical protein NP_274995.1 2115518 D 122586 CDS NP_274996.1 15677832 904117 2115862..2116554 1 NC_003112.2 identified by similarity to EGAD:8297; match to protein family HMM PF04172; hypothetical protein 2116554 904117 NMB2004 Neisseria meningitidis MC58 hypothetical protein NP_274996.1 2115862 D 122586 CDS NP_274997.1 15677833 904115 2116621..2117841 1 NC_003112.2 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 2117841 argJ 904115 argJ Neisseria meningitidis MC58 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase NP_274997.1 2116621 D 122586 CDS NP_274998.1 15677834 904114 2117901..2119310 1 NC_003112.2 identified by similarity to EGAD:47927; match to protein family HMM PF00654; chloride channel protein-related protein 2119310 904114 NMB2006 Neisseria meningitidis MC58 chloride channel protein-related protein NP_274998.1 2117901 D 122586 CDS NP_274999.1 15678020 903117 2119500..2120891 1 NC_003112.2 identified by similarity to GP:1742299; ATP-dependent DNA helicase 2120891 903117 NMB2007 Neisseria meningitidis MC58 ATP-dependent DNA helicase NP_274999.1 2119500 D 122586 CDS NP_275000.1 15677835 904113 2121035..2122678 1 NC_003112.2 identified by similarity to EGAD:42946; ABC transporter ATP-binding protein-like protein 2122678 904113 NMB2008 Neisseria meningitidis MC58 ABC transporter ATP-binding protein-like protein NP_275000.1 2121035 D 122586 CDS NP_275002.1 15677836 904111 2123116..2124693 1 NC_003112.2 identified by similarity to EGAD:8243; match to protein family HMM PF00884; hypothetical protein 2124693 904111 NMB2010 Neisseria meningitidis MC58 hypothetical protein NP_275002.1 2123116 D 122586 CDS NP_275003.1 15678022 903114 2124759..2128178 1 NC_003112.2 identified by similarity to GP:1742310; ATP-dependent RNA helicase HrpA, truncation 2128178 903114 NMB2011 Neisseria meningitidis MC58 ATP-dependent RNA helicase HrpA, truncation NP_275003.1 2124759 D 122586 CDS NP_275004.1 15677837 904110 complement(2128211..2129302) 1 NC_003112.2 identified by similarity to EGAD:161488; match to protein family HMM PF06114; match to protein family HMM TIGR01199; transcriptional regulator 2129302 904110 NMB2012 Neisseria meningitidis MC58 transcriptional regulator NP_275004.1 2128211 R 122586 CDS NP_275005.1 15677838 904109 complement(2129318..2129962) 1 NC_003112.2 hypothetical protein 2129962 904109 NMB2013 Neisseria meningitidis MC58 hypothetical protein NP_275005.1 2129318 R 122586 CDS NP_275007.1 15677840 904107 2130656..2130925 1 NC_003112.2 hypothetical protein 2130925 904107 NMB2015 Neisseria meningitidis MC58 hypothetical protein NP_275007.1 2130656 D 122586 CDS NP_275008.1 15677841 904106 complement(2131086..2131535) 1 NC_003112.2 identified by similarity to GP:2073462; match to protein family HMM PF07963; match to protein family HMM TIGR02532; type IV pilin-like protein 2131535 904106 NMB2016 Neisseria meningitidis MC58 type IV pilin-like protein NP_275008.1 2131086 R 122586 CDS NP_275009.1 15677842 904104 complement(2131623..2132069) 1 NC_003112.2 identified by similarity to EGAD:18958; match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; ComEA-like protein 2132069 904104 NMB2017 Neisseria meningitidis MC58 ComEA-like protein NP_275009.1 2131623 R 122586 CDS NP_275010.1 15677843 904093 complement(2137791..2138453) 1 NC_003112.2 identified by similarity to EGAD:27877; match to protein family HMM PF00849; match to protein family HMM TIGR01621; hypothetical protein 2138453 904093 NMB2018 Neisseria meningitidis MC58 hypothetical protein NP_275010.1 2137791 R 122586 CDS NP_275011.1 15677844 904092 complement(2138479..2138991) 1 NC_003112.2 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2138991 coaD 904092 coaD Neisseria meningitidis MC58 phosphopantetheine adenylyltransferase NP_275011.1 2138479 R 122586 CDS NP_275012.1 15677845 904090 complement(2139115..2139798) 1 NC_003112.2 identified by similarity to EGAD:6204; match to protein family HMM PF01027; hypothetical protein 2139798 904090 NMB2020 Neisseria meningitidis MC58 hypothetical protein NP_275012.1 2139115 R 122586 CDS NP_275013.1 15677846 904089 complement(2139955..2140221) 1 NC_003112.2 identified by similarity to EGAD:27927; match to protein family HMM PF04362; hypothetical protein 2140221 904089 NMB2021 Neisseria meningitidis MC58 hypothetical protein NP_275013.1 2139955 R 122586 CDS NP_275014.1 15677847 904088 complement(2140294..2140764) 1 NC_003112.2 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2140764 904088 NMB2022 Neisseria meningitidis MC58 rRNA large subunit methyltransferase NP_275014.1 2140294 R 122586 CDS NP_275015.1 15677848 904084 complement(2140818..2141204) 1 NC_003112.2 identified by similarity to EGAD:27850; match to protein family HMM PF02410; match to protein family HMM TIGR00090; hypothetical protein 2141204 904084 NMB2023 Neisseria meningitidis MC58 hypothetical protein NP_275015.1 2140818 R 122586 CDS NP_275016.1 15677849 904082 complement(2141263..2141868) 1 NC_003112.2 identified by similarity to EGAD:45797; match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR00482; hypothetical protein 2141868 904082 NMB2024 Neisseria meningitidis MC58 hypothetical protein NP_275016.1 2141263 R 122586 CDS NP_275017.1 15677850 904081 complement(2141865..2142464) 1 NC_003112.2 identified by similarity to EGAD:108434; match to protein family HMM PF00484; hypothetical protein 2142464 904081 NMB2025 Neisseria meningitidis MC58 hypothetical protein NP_275017.1 2141865 R 122586 CDS NP_275018.1 15677851 904080 complement(2142493..2144088) 1 NC_003112.2 identified by similarity to GP:3319739; match to protein family HMM PF00528; ABC transporter permease 2144088 904080 NMB2026 Neisseria meningitidis MC58 ABC transporter permease NP_275018.1 2142493 R 122586 CDS NP_275019.1 15677852 904076 2144427..2145812 1 NC_003112.2 identified by similarity to EGAD:36585; match to protein family HMM PF02447; match to protein family HMM TIGR00791; gluconate permease 2145812 gntP 904076 gntP Neisseria meningitidis MC58 gluconate permease NP_275019.1 2144427 D 122586 CDS NP_275020.1 15677853 904075 2145832..2146350 1 NC_003112.2 identified by similarity to EGAD:30331; match to protein family HMM TIGR01313; thermoresistant gluconokinase 2146350 gntK 904075 gntK Neisseria meningitidis MC58 thermoresistant gluconokinase NP_275020.1 2145832 D 122586 CDS NP_275021.1 15678023 903113 complement(2146689..2147606) 1 NC_003112.2 catalyzes the formation of O-phospho-L-homoserine from L-homoserine; homoserine kinase 2147606 thrB 903113 thrB Neisseria meningitidis MC58 homoserine kinase NP_275021.1 2146689 R 122586 CDS NP_275022.1 15677854 904071 complement(2147643..2148371) 1 NC_003112.2 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2148371 ubiG 904071 ubiG Neisseria meningitidis MC58 3-demethylubiquinone-9 3-methyltransferase NP_275022.1 2147643 R 122586 CDS NP_275023.1 15677855 904070 2148523..2149764 1 NC_003112.2 identified by similarity to EGAD:28929; match to protein family HMM PF03222; match to protein family HMM TIGR00837; amino-acid transport protein 2149764 mtr 904070 mtr Neisseria meningitidis MC58 amino-acid transport protein NP_275023.1 2148523 D 122586 CDS NP_275024.1 15677856 904065 2151215..2151778 1 NC_003112.2 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 2151778 904065 NMB2033 Neisseria meningitidis MC58 D,D-heptose 1,7-bisphosphate phosphatase NP_275024.1 2151215 D 122586 CDS NP_275025.1 15677857 904064 2151807..2152550 1 NC_003112.2 identified by similarity to EGAD:162666; match to protein family HMM PF01553; 1-acyl-SN-glycerol-3-phosphate acyltransferase 2152550 904064 NMB2034 Neisseria meningitidis MC58 1-acyl-SN-glycerol-3-phosphate acyltransferase NP_275025.1 2151807 D 122586 CDS NP_275026.1 15677858 904063 2152547..2153239 1 NC_003112.2 identified by similarity to EGAD:105006; match to protein family HMM PF01863; hypothetical protein 2153239 904063 NMB2035 Neisseria meningitidis MC58 hypothetical protein NP_275026.1 2152547 D 122586 CDS NP_275027.1 15677859 904060 2154537..2155334 1 NC_003112.2 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2155334 truA 904060 truA Neisseria meningitidis MC58 tRNA pseudouridine synthase A NP_275027.1 2154537 D 122586 CDS NP_275028.1 15677860 904059 2155457..2155696 1 NC_003112.2 hypothetical protein 2155696 904059 NMB2037 Neisseria meningitidis MC58 hypothetical protein NP_275028.1 2155457 D 122586 CDS NP_275029.1 15677861 904055 2155684..2156007 1 NC_003112.2 identified by similarity to EGAD:108126; match to protein family HMM PF02452; PemK-like protein 2156007 904055 NMB2038 Neisseria meningitidis MC58 PemK-like protein NP_275029.1 2155684 D 122586 CDS NP_275030.1 15677862 904054 2157529..2158524 1 NC_003112.2 identified by similarity to EGAD:7492; match to protein family HMM PF00267; major outer membrane protein PIB 2158524 porB 904054 porB Neisseria meningitidis MC58 major outer membrane protein PIB NP_275030.1 2157529 D 122586 CDS NP_275031.1 15677863 904053 complement(2159620..2161521) 1 NC_003112.2 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 2161521 thiC 904053 thiC Neisseria meningitidis MC58 thiamine biosynthesis protein ThiC NP_275031.1 2159620 R 122586 CDS NP_275032.1 15677864 904050 2162135..2163010 1 NC_003112.2 identified by similarity to EGAD:53884; match to protein family HMM PF00293; thiamin pyrophosphokinase-like protein 2163010 904050 NMB2041 Neisseria meningitidis MC58 thiamin pyrophosphokinase-like protein NP_275032.1 2162135 D 122586 CDS NP_275033.1 15677865 904049 2163019..2163957 1 NC_003112.2 identified by similarity to EGAD:28341; match to protein family HMM PF00005; ABC transporter ATP-binding protein 2163957 potA-2 904049 potA-2 Neisseria meningitidis MC58 ABC transporter ATP-binding protein NP_275033.1 2163019 D 122586 CDS NP_275034.1 15677866 904047 complement(2166545..2168320) 1 NC_003112.2 identified by similarity to EGAD:19051; match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase 2168320 ptsI 904047 ptsI Neisseria meningitidis MC58 phosphoenolpyruvate-protein phosphotransferase NP_275034.1 2166545 R 122586 CDS NP_275035.1 15677867 904045 complement(2168320..2168589) 1 NC_003112.2 identified by similarity to EGAD:17827; match to protein family HMM PF00381; match to protein family HMM TIGR01003; sugar transport PTS system phosphocarrier protein HPr 2168589 ptsH 904045 ptsH Neisseria meningitidis MC58 sugar transport PTS system phosphocarrier protein HPr NP_275035.1 2168320 R 122586 CDS NP_275036.1 15677868 904044 complement(2168658..2169116) 1 NC_003112.2 identified by similarity to EGAD:24904; match to protein family HMM PF03610; PTS system, IIAB component 2169116 904044 NMB2046 Neisseria meningitidis MC58 PTS system, IIAB component NP_275036.1 2168658 R 122586 CDS NP_275037.1 15677869 904042 complement(2169176..2169739) 1 NC_003112.2 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 2169739 904042 NMB2047 Neisseria meningitidis MC58 hypoxanthine-guanine phosphoribosyltransferase NP_275037.1 2169176 R 122586 CDS NP_275038.1 15677870 904041 complement(2169808..2170632) 1 NC_003112.2 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 2170632 ligA-2 904041 ligA-2 Neisseria meningitidis MC58 DNA ligase NP_275038.1 2169808 R 122586 CDS NP_275039.1 15677871 904038 2170724..2171356 1 NC_003112.2 identified by similarity to EGAD:91564; match to protein family HMM PF00753; glyoxalase II family protein 2171356 904038 NMB2049 Neisseria meningitidis MC58 glyoxalase II family protein NP_275039.1 2170724 D 122586 CDS NP_275040.1 15677872 904037 complement(2171563..2173347) 1 NC_003112.2 identified by similarity to EGAD:23818; match to protein family HMM PF02646; hypothetical protein 2173347 904037 NMB2050 Neisseria meningitidis MC58 hypothetical protein NP_275040.1 2171563 R 122586 CDS NP_275041.1 15677873 904035 complement(2173686..2174486) 1 NC_003112.2 identified by similarity to EGAD:10603; match to protein family HMM PF02167; cytochrome C1 precursor 2174486 petC 904035 petC Neisseria meningitidis MC58 cytochrome C1 precursor NP_275041.1 2173686 R 122586 CDS NP_275042.1 15677874 904030 complement(2174486..2175835) 1 NC_003112.2 identified by similarity to EGAD:10936; match to protein family HMM PF00032; match to protein family HMM PF00033; cytochrome B 2175835 petB 904030 petB Neisseria meningitidis MC58 cytochrome B NP_275042.1 2174486 R 122586 CDS NP_275043.1 15677875 904028 complement(2175854..2176435) 1 NC_003112.2 identified by similarity to EGAD:24965; match to protein family HMM PF00355; match to protein family HMM TIGR01409; match to protein family HMM TIGR01416; ubiquinol-cytochrome c reductase iron-sulfur subunit 2176435 petA 904028 petA Neisseria meningitidis MC58 ubiquinol-cytochrome c reductase iron-sulfur subunit NP_275043.1 2175854 R 122586 CDS NP_275044.1 15677876 904027 complement(2176558..2177307) 1 NC_003112.2 identified by similarity to EGAD:109841; match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein 2177307 904027 NMB2054 Neisseria meningitidis MC58 hypothetical protein NP_275044.1 2176558 R 122586 CDS NP_275045.1 15677877 904026 2177438..2178367 1 NC_003112.2 identified by similarity to EGAD:28725; match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 2178367 904026 NMB2055 Neisseria meningitidis MC58 LysR family transcriptional regulator NP_275045.1 2177438 D 122586 CDS NP_275046.1 15677878 904024 complement(2178622..2179014) 1 NC_003112.2 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 2179014 rpsI 904024 rpsI Neisseria meningitidis MC58 30S ribosomal protein S9 NP_275046.1 2178622 R 122586 CDS NP_275047.1 15677879 904023 complement(2179024..2179455) 1 NC_003112.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 2179455 rplM 904023 rplM Neisseria meningitidis MC58 50S ribosomal protein L13 NP_275047.1 2179024 R 122586 CDS NP_275048.1 15677880 904022 complement(2179818..2180123) 1 NC_003112.2 identified by similarity to EGAD:29842; match to protein family HMM PF05164; hypothetical protein 2180123 904022 NMB2058 Neisseria meningitidis MC58 hypothetical protein NP_275048.1 2179818 R 122586 CDS NP_275049.1 15677881 904021 complement(2180134..2180463) 1 NC_003112.2 hypothetical protein 2180463 904021 NMB2059 Neisseria meningitidis MC58 hypothetical protein NP_275049.1 2180134 R 122586 CDS NP_275050.1 15677882 904020 complement(2180518..2181507) 1 NC_003112.2 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2181507 gpsA 904020 gpsA Neisseria meningitidis MC58 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_275050.1 2180518 R 122586 CDS NP_275051.1 15677883 904019 complement(2181630..2184332) 1 NC_003112.2 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 2184332 ppc 904019 ppc Neisseria meningitidis MC58 phosphoenolpyruvate carboxylase NP_275051.1 2181630 R 122586 CDS NP_275052.1 15677884 904016 2184502..2185272 1 NC_003112.2 identified by similarity to EGAD:12848; match to protein family HMM PF00899; match to protein family HMM PF05237; thiF protein 2185272 thiF 904016 thiF Neisseria meningitidis MC58 thiF protein NP_275052.1 2184502 D 122586 CDS NP_275053.1 15677885 904015 complement(2185836..2186060) 1 NC_003112.2 identified by similarity to EGAD:19441; match to protein family HMM PF04102; hypothetical protein 2186060 904015 NMB2063 Neisseria meningitidis MC58 hypothetical protein NP_275053.1 2185836 R 122586 CDS NP_275054.1 15677886 904014 complement(2186061..2187449) 1 NC_003112.2 identified by similarity to EGAD:28966; match to protein family HMM PF03553; hypothetical protein 2187449 904014 NMB2064 Neisseria meningitidis MC58 hypothetical protein NP_275054.1 2186061 R 122586 CDS NP_275055.1 15677887 904010 complement(2187535..2188806) 1 NC_003112.2 identified by similarity to EGAD:37566; match to protein family HMM TIGR00536; hemK protein 2188806 hemK 904010 hemK Neisseria meningitidis MC58 hemK protein NP_275055.1 2187535 R 122586 CDS NP_275056.1 15677888 904006 complement(2188871..2190313) 1 NC_003112.2 identified by similarity to EGAD:30245; match to protein family HMM PF01523; tldD protein 2190313 tldD 904006 tldD Neisseria meningitidis MC58 tldD protein NP_275056.1 2188871 R 122586 CDS NP_275057.1 15677889 904005 2190703..2191926 1 NC_003112.2 identified by similarity to EGAD:158421; match to protein family HMM PF02133; match to protein family HMM TIGR02358; hydroxymethylpyrimidine transporter CytX 2191926 cytX 904005 cytX Neisseria meningitidis MC58 hydroxymethylpyrimidine transporter CytX NP_275057.1 2190703 D 122586 CDS NP_275058.1 15677890 904004 2191923..2193023 1 NC_003112.2 identified by similarity to GP:2627327; match to protein family HMM PF01266; glycine oxidase ThiO 2193023 thiO 904004 thiO Neisseria meningitidis MC58 glycine oxidase ThiO NP_275058.1 2191923 D 122586 CDS NP_275059.1 15677891 904001 2193045..2193662 1 NC_003112.2 identified by similarity to EGAD:10927; match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamin-phosphate pyrophosphorylase 2193662 thiE 904001 thiE Neisseria meningitidis MC58 thiamin-phosphate pyrophosphorylase NP_275059.1 2193045 D 122586 CDS NP_275060.1 15677892 903999 2194084..2194278 1 NC_003112.2 identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683; thiamine biosynthesis protein ThiS 2194278 thiS 903999 thiS Neisseria meningitidis MC58 thiamine biosynthesis protein ThiS NP_275060.1 2194084 D 122586 CDS NP_275061.1 15677893 903997 2194492..2195280 1 NC_003112.2 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 2195280 thiG 903997 thiG Neisseria meningitidis MC58 thiazole synthase NP_275061.1 2194492 D 122586 CDS NP_275062.1 15677894 903995 2195394..2195537 1 NC_003112.2 hypothetical protein 2195537 903995 NMB2072 Neisseria meningitidis MC58 hypothetical protein NP_275062.1 2195394 D 122586 CDS NP_275064.1 15677896 903992 complement(2196043..2196909) 1 NC_003112.2 hypothetical protein 2196909 903992 NMB2074 Neisseria meningitidis MC58 hypothetical protein NP_275064.1 2196043 R 122586 CDS NP_275065.1 15677897 903989 complement(2196921..2198699) 1 NC_003112.2 activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins and catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase 2198699 903989 NMB2075 Neisseria meningitidis MC58 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase NP_275065.1 2196921 R 122586 CDS NP_275066.1 15677898 903988 complement(2198696..2199202) 1 NC_003112.2 identified by similarity to EGAD:41926; match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR02199; aut protein 2199202 aut 903988 aut Neisseria meningitidis MC58 aut protein NP_275066.1 2198696 R 122586 CDS NP_275067.1 15677899 903978 complement(2200757..2201338) 1 NC_003112.2 identified by similarity to EGAD:28554; match to protein family HMM PF06271; hypothetical protein 2201338 903978 NMB2078 Neisseria meningitidis MC58 hypothetical protein NP_275067.1 2200757 R 122586 CDS NP_275068.1 15677900 903977 2201514..2202629 1 NC_003112.2 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 2202629 asd 903977 asd Neisseria meningitidis MC58 aspartate-semialdehyde dehydrogenase NP_275068.1 2201514 D 122586 CDS NP_275069.1 15677901 903975 complement(2202857..2203387) 1 NC_003112.2 hypothetical protein 2203387 903975 NMB2080 Neisseria meningitidis MC58 hypothetical protein NP_275069.1 2202857 R 122586 CDS NP_275070.1 15677902 903974 complement(2203398..2203742) 1 NC_003112.2 hypothetical protein 2203742 903974 NMB2081 Neisseria meningitidis MC58 hypothetical protein NP_275070.1 2203398 R 122586 CDS NP_275071.1 15677903 903973 complement(2203729..2204508) 1 NC_003112.2 identified by similarity to EGAD:19899; match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease 2204508 exoA 903973 exoA Neisseria meningitidis MC58 exodeoxyribonuclease NP_275071.1 2203729 R 122586 CDS NP_275072.1 15677904 903970 complement(2204591..2206012) 1 NC_003112.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 2206012 cysS 903970 cysS Neisseria meningitidis MC58 cysteinyl-tRNA synthetase NP_275072.1 2204591 R 122586 CDS NP_275073.1 15677905 903967 complement(2206700..2207749) 1 NC_003112.2 hypothetical protein 2207749 903967 NMB2085 Neisseria meningitidis MC58 hypothetical protein NP_275073.1 2206700 R 122586 CDS NP_275074.1 15677906 903966 complement(2207832..2208986) 1 NC_003112.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 2208986 obgE 903966 obgE Neisseria meningitidis MC58 GTPase ObgE NP_275074.1 2207832 R 122586 CDS NP_275075.1 15677907 903964 complement(2209472..2209834) 1 NC_003112.2 hypothetical protein 2209834 903964 NMB2087 Neisseria meningitidis MC58 hypothetical protein NP_275075.1 2209472 R 122586 CDS NP_275076.1 15677908 903963 complement(2209933..2210808) 1 NC_003112.2 identified by similarity to EGAD:28643; match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 2210808 903963 NMB2088 Neisseria meningitidis MC58 hypothetical protein NP_275076.1 2209933 R 122586 CDS NP_275077.1 15677909 903961 2210854..2211201 1 NC_003112.2 identified by similarity to EGAD:89286; match to protein family HMM PF02021; match to protein family HMM TIGR00252; hypothetical protein 2211201 903961 NMB2089 Neisseria meningitidis MC58 hypothetical protein NP_275077.1 2210854 D 122586 CDS NP_275078.1 15677910 903960 2211206..2211799 1 NC_003112.2 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 2211799 gmhA 903960 gmhA Neisseria meningitidis MC58 phosphoheptose isomerase NP_275078.1 2211206 D 122586 CDS NP_275079.1 15677911 903958 2211863..2212471 1 NC_003112.2 identified by similarity to EGAD:28637; match to protein family HMM PF04972; hemolysin 2212471 903958 NMB2091 Neisseria meningitidis MC58 hemolysin NP_275079.1 2211863 D 122586 CDS NP_275080.1 15677912 903956 2212479..2213111 1 NC_003112.2 hypothetical protein 2213111 903956 NMB2092 Neisseria meningitidis MC58 hypothetical protein NP_275080.1 2212479 D 122586 CDS NP_275081.1 15677913 903955 2213151..2213930 1 NC_003112.2 identified by similarity to EGAD:13057; match to protein family HMM PF00557; match to protein family HMM TIGR00500; methionine aminopeptidase 2213930 map 903955 map Neisseria meningitidis MC58 methionine aminopeptidase NP_275081.1 2213151 D 122586 CDS NP_275082.1 15677914 903952 2214085..2214384 1 NC_003112.2 hypothetical protein 2214384 903952 NMB2094 Neisseria meningitidis MC58 hypothetical protein NP_275082.1 2214085 D 122586 CDS NP_275083.1 15677915 903950 2214622..2214996 1 NC_003112.2 identified by similarity to EGAD:126793; adhesin complex protein 2214996 903950 NMB2095 Neisseria meningitidis MC58 adhesin complex protein NP_275083.1 2214622 D 122586 CDS NP_275084.1 15677916 903948 complement(2215184..2216650) 1 NC_003112.2 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2216650 yojH 903948 yojH Neisseria meningitidis MC58 malate:quinone oxidoreductase NP_275084.1 2215184 R 122586 CDS NP_275085.1 15677917 903947 complement(2216702..2216791) 1 NC_003112.2 hypothetical protein 2216791 903947 NMB2097 Neisseria meningitidis MC58 hypothetical protein NP_275085.1 2216702 R 122586 CDS NP_275086.1 15677918 903946 complement(2217187..2217777) 1 NC_003112.2 identified by similarity to GP:2897873; hypothetical protein 2217777 903946 NMB2098 Neisseria meningitidis MC58 hypothetical protein NP_275086.1 2217187 R 122586 CDS NP_275087.1 15677919 903943 complement(2217838..2218419) 1 NC_003112.2 identified by similarity to EGAD:33024; match to protein family HMM PF01812; hypothetical protein 2218419 903943 NMB2099 Neisseria meningitidis MC58 hypothetical protein NP_275087.1 2217838 R 122586 CDS NP_275088.1 15677920 903941 2218497..2218730 1 NC_003112.2 hypothetical protein 2218730 903941 NMB2100 Neisseria meningitidis MC58 hypothetical protein NP_275088.1 2218497 D 122586 CDS NP_275089.1 15677921 903940 2218903..2219631 1 NC_003112.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2219631 rpsB 903940 rpsB Neisseria meningitidis MC58 30S ribosomal protein S2 NP_275089.1 2218903 D 122586 CDS NP_275090.1 15677922 903937 2219760..2220614 1 NC_003112.2 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2220614 tsf 903937 tsf Neisseria meningitidis MC58 elongation factor Ts NP_275090.1 2219760 D 122586 CDS NP_275091.1 15677923 903933 2220831..2221550 1 NC_003112.2 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 2221550 pyrH 903933 pyrH Neisseria meningitidis MC58 uridylate kinase NP_275091.1 2220831 D 122586 CDS NP_275092.1 15677924 903930 2222737..2224188 1 NC_003112.2 identified by similarity to GP:4838555; match to protein family HMM PF06255; mafB protein 2224188 mafB 903930 mafB Neisseria meningitidis MC58 mafB protein NP_275092.1 2222737 D 122586 CDS NP_275093.1 15677925 903929 2224185..2224541 1 NC_003112.2 hypothetical protein 2224541 903929 NMB2106 Neisseria meningitidis MC58 hypothetical protein NP_275093.1 2224185 D 122586 CDS NP_275097.1 15677928 903922 2225929..2226300 1 NC_003112.2 hypothetical protein 2226300 903922 NMB2110 Neisseria meningitidis MC58 hypothetical protein NP_275097.1 2225929 D 122586 CDS NP_275099.1 15677929 903919 2227348..2227617 1 NC_003112.2 hypothetical protein 2227617 903919 NMB2112 Neisseria meningitidis MC58 hypothetical protein NP_275099.1 2227348 D 122586 CDS NP_275100.1 15677930 903519 2227640..2227942 1 NC_003112.2 hypothetical protein 2227942 903519 NMB2113 Neisseria meningitidis MC58 hypothetical protein NP_275100.1 2227640 D 122586 CDS NP_275102.1 15677931 903512 2228631..2228975 1 NC_003112.2 hypothetical protein 2228975 903512 NMB2115 Neisseria meningitidis MC58 hypothetical protein NP_275102.1 2228631 D 122586 CDS NP_275103.1 15677932 903511 2229013..2229357 1 NC_003112.2 hypothetical protein 2229357 903511 NMB2116 Neisseria meningitidis MC58 hypothetical protein NP_275103.1 2229013 D 122586 CDS NP_275104.1 15677933 903488 2230382..2230699 1 NC_003112.2 hypothetical protein 2230699 903488 NMB2118 Neisseria meningitidis MC58 hypothetical protein NP_275104.1 2230382 D 122586 CDS NP_275106.1 15677934 903473 2231513..2231914 1 NC_003112.2 hypothetical protein 2231914 903473 NMB2120 Neisseria meningitidis MC58 hypothetical protein NP_275106.1 2231513 D 122586 CDS NP_275107.1 15677935 903454 2232073..2232417 1 NC_003112.2 hypothetical protein 2232417 903454 NMB2121 Neisseria meningitidis MC58 hypothetical protein NP_275107.1 2232073 D 122586 CDS NP_275108.1 15677936 903449 2232451..2232555 1 NC_003112.2 identified by similarity to GP:4838555; MafB-like protein 2232555 903449 NMB2122 Neisseria meningitidis MC58 MafB-like protein NP_275108.1 2232451 D 122586 CDS NP_275109.1 15677937 903432 2232560..2232916 1 NC_003112.2 hypothetical protein 2232916 903432 NMB2123 Neisseria meningitidis MC58 hypothetical protein NP_275109.1 2232560 D 122586 CDS NP_275110.1 15677938 903427 2232964..2233092 1 NC_003112.2 hypothetical protein 2233092 903427 NMB2124 Neisseria meningitidis MC58 hypothetical protein NP_275110.1 2232964 D 122586 CDS NP_275111.1 15677939 903416 2233089..2233463 1 NC_003112.2 hypothetical protein 2233463 903416 NMB2125 Neisseria meningitidis MC58 hypothetical protein NP_275111.1 2233089 D 122586 CDS NP_275112.1 15677940 903411 complement(2234420..2235406) 1 NC_003112.2 identified by similarity to EGAD:106898; match to protein family HMM PF01343; protease 2235406 903411 NMB2127 Neisseria meningitidis MC58 protease NP_275112.1 2234420 R 122586 CDS NP_275113.1 15677941 903407 complement(2235446..2236246) 1 NC_003112.2 identified by similarity to EGAD:103771; CinA-like protein 2236246 903407 NMB2128 Neisseria meningitidis MC58 CinA-like protein NP_275113.1 2235446 R 122586 CDS NP_275114.1 15677942 903396 2236559..2237902 1 NC_003112.2 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 2237902 argG 903396 argG Neisseria meningitidis MC58 argininosuccinate synthase NP_275114.1 2236559 D 122586 CDS NP_275115.1 15677943 903377 2237950..2238192 1 NC_003112.2 hypothetical protein 2238192 903377 NMB2130 Neisseria meningitidis MC58 hypothetical protein NP_275115.1 2237950 D 122586 CDS NP_275116.1 15677944 903373 2238185..2238400 1 NC_003112.2 hypothetical protein 2238400 903373 NMB2131 Neisseria meningitidis MC58 hypothetical protein NP_275116.1 2238185 D 122586 CDS NP_275117.1 15677945 903357 complement(2238476..2239942) 1 NC_003112.2 identified by similarity to EGAD:39989; match to protein family HMM PF01298; transferrin-binding protein-like protein 2239942 903357 NMB2132 Neisseria meningitidis MC58 transferrin-binding protein-like protein NP_275117.1 2238476 R 122586 CDS NP_275118.1 15677946 903354 complement(2240197..2241426) 1 NC_003112.2 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 2241426 903354 NMB2133 Neisseria meningitidis MC58 serine/threonine transporter SstT NP_275118.1 2240197 R 122586 CDS NP_275119.1 15677947 903298 2241899..2243806 1 NC_003112.2 identified by similarity to EGAD:24660; match to protein family HMM PF01103; hypothetical protein 2243806 903298 NMB2134 Neisseria meningitidis MC58 hypothetical protein NP_275119.1 2241899 D 122586 CDS NP_275120.1 15677948 903264 2243813..2248030 1 NC_003112.2 identified by similarity to EGAD:29466; match to protein family HMM PF04357; hypothetical protein 2248030 903264 NMB2135 Neisseria meningitidis MC58 hypothetical protein NP_275120.1 2243813 D 122586 CDS NP_275121.1 15677949 903237 2249513..2250970 1 NC_003112.2 identified by similarity to EGAD:108941; match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924; peptide transporter 2250970 903237 NMB2136 Neisseria meningitidis MC58 peptide transporter NP_275121.1 2249513 D 122586 CDS NP_275123.1 15677951 903234 complement(2251863..2252966) 1 NC_003112.2 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 2252966 prfB 903234 prfB Neisseria meningitidis MC58 peptide chain release factor 2 NP_275123.1 2251863 R 122586 CDS NP_275124.1 15677952 903233 complement(2253069..2253962) 1 NC_003112.2 identified by similarity to EGAD:108195; match to protein family HMM PF01734; hypothetical protein 2253962 903233 NMB2139 Neisseria meningitidis MC58 hypothetical protein NP_275124.1 2253069 R 122586 CDS NP_275125.1 15677953 903232 2254307..2254756 1 NC_003112.2 identified by similarity to EGAD:28593; match to protein family HMM PF07681; hypothetical protein 2254756 903232 NMB2140 Neisseria meningitidis MC58 hypothetical protein NP_275125.1 2254307 D 122586 CDS NP_275126.1 15677954 903231 2254829..2255137 1 NC_003112.2 hypothetical protein 2255137 903231 NMB2141 Neisseria meningitidis MC58 hypothetical protein NP_275126.1 2254829 D 122586 CDS NP_275127.1 15677955 903230 2255229..2256095 1 NC_003112.2 identified by similarity to EGAD:28591; match to protein family HMM PF05114; hypothetical protein 2256095 903230 NMB2142 Neisseria meningitidis MC58 hypothetical protein NP_275127.1 2255229 D 122586 CDS NP_275128.1 15677956 903229 2256085..2256831 1 NC_003112.2 identified by similarity to EGAD:28581; hypothetical protein 2256831 903229 NMB2143 Neisseria meningitidis MC58 hypothetical protein NP_275128.1 2256085 D 122586 CDS NP_275129.1 15677957 903228 2256853..2257440 1 NC_003112.2 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 2257440 903228 NMB2144 Neisseria meningitidis MC58 RNA polymerase sigma factor NP_275129.1 2256853 D 122586 CDS NP_275130.1 15677958 903227 2257446..2257625 1 NC_003112.2 hypothetical protein 2257625 903227 NMB2145 Neisseria meningitidis MC58 hypothetical protein NP_275130.1 2257446 D 122586 CDS NP_275131.1 15677959 903226 2257745..2257855 1 NC_003112.2 hypothetical protein 2257855 903226 NMB2146 Neisseria meningitidis MC58 hypothetical protein NP_275131.1 2257745 D 122586 CDS NP_275132.1 15677960 903225 2257884..2258306 1 NC_003112.2 hypothetical protein 2258306 903225 NMB2147 Neisseria meningitidis MC58 hypothetical protein NP_275132.1 2257884 D 122586 CDS NP_275133.1 15677961 903224 2258780..2259745 1 NC_003112.2 identified by similarity to EGAD:9780; match to protein family HMM PF00665; match to protein family HMM TIGR01199; IS30 family transposase 2259745 903224 NMB2148 Neisseria meningitidis MC58 IS30 family transposase NP_275133.1 2258780 D 122586 CDS NP_275134.1 15677962 903223 complement(2259834..2260094) 1 NC_003112.2 hypothetical protein 2260094 903223 NMB2149 Neisseria meningitidis MC58 hypothetical protein NP_275134.1 2259834 R 122586 CDS NP_275135.1 15677963 903222 complement(2260479..2261048) 1 NC_003112.2 identified by similarity to GP:606216; match to protein family HMM PF01300; hypothetical protein 2261048 903222 NMB2150 Neisseria meningitidis MC58 hypothetical protein NP_275135.1 2260479 R 122586 CDS NP_275136.1 15677964 903221 complement(2261115..2262386) 1 NC_003112.2 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 2262386 purD 903221 purD Neisseria meningitidis MC58 phosphoribosylamine--glycine ligase NP_275136.1 2261115 R 122586 CDS NP_275137.1 15677965 903220 2262544..2262861 1 NC_003112.2 hypothetical protein 2262861 903220 NMB2152 Neisseria meningitidis MC58 hypothetical protein NP_275137.1 2262544 D 122586 CDS NP_275138.1 15677966 903219 complement(2262913..2263524) 1 NC_003112.2 identified by similarity to EGAD:91869; match to protein family HMM PF01205; hypothetical protein 2263524 903219 NMB2153 Neisseria meningitidis MC58 hypothetical protein NP_275138.1 2262913 R 122586 CDS NP_275139.1 15677967 903218 complement(2263587..2264522) 1 NC_003112.2 identified by similarity to EGAD:45711; match to protein family HMM PF00766; electron transfer flavoprotein subunit alpha 2264522 etfA 903218 etfA Neisseria meningitidis MC58 electron transfer flavoprotein subunit alpha NP_275139.1 2263587 R 122586 CDS NP_275140.1 15677968 903217 complement(2264533..2265282) 1 NC_003112.2 identified by similarity to EGAD:40692; match to protein family HMM PF01012; electron transfer flavoprotein subunit beta 2265282 etfB 903217 etfB Neisseria meningitidis MC58 electron transfer flavoprotein subunit beta NP_275140.1 2264533 R 122586 CDS NP_275141.1 15677969 903216 complement(2265509..2266477) 1 NC_003112.2 identified by similarity to EGAD:40648; match to protein family HMM PF01075; match to protein family HMM TIGR02193; lipopolysaccharide heptosyltransferase I 2266477 rfaC 903216 rfaC Neisseria meningitidis MC58 lipopolysaccharide heptosyltransferase I NP_275141.1 2265509 R 122586 CDS NP_275142.1 15677970 903215 complement(2266514..2267149) 1 NC_003112.2 identified by similarity to EGAD:140533; match to protein family HMM PF00857; pyrazinamidase/nicotinamidase PncA 2267149 903215 NMB2157 Neisseria meningitidis MC58 pyrazinamidase/nicotinamidase PncA NP_275142.1 2266514 R 122586 CDS NP_275143.1 15677971 903214 2267263..2267943 1 NC_003112.2 identified by similarity to EGAD:21511; match to protein family HMM PF01980; match to protein family HMM TIGR00104; hypothetical protein 2267943 903214 NMB2158 Neisseria meningitidis MC58 hypothetical protein NP_275143.1 2267263 D 122586 CDS NP_275144.1 15677972 903213 complement(2268201..2269205) 1 NC_003112.2 identified by similarity to EGAD:22254; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde 3-phosphate dehydrogenase C 2269205 gapA-2 903213 gapA-2 Neisseria meningitidis MC58 glyceraldehyde 3-phosphate dehydrogenase C NP_275144.1 2268201 R 122586 CDS NP_275145.1 15677973 903212 2269649..2272243 1 NC_003112.2 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2272243 mutS 903212 mutS Neisseria meningitidis MC58 DNA mismatch repair protein MutS NP_275145.1 2269649 D 122586 CDS