-- dump date   	20140619_155040
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
478435000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
478435000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435000003	Walker A motif; other site
478435000004	ATP binding site [chemical binding]; other site
478435000005	Walker B motif; other site
478435000006	arginine finger; other site
478435000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
478435000008	DnaA box-binding interface [nucleotide binding]; other site
478435000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
478435000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
478435000011	putative DNA binding surface [nucleotide binding]; other site
478435000012	dimer interface [polypeptide binding]; other site
478435000013	beta-clamp/clamp loader binding surface; other site
478435000014	beta-clamp/translesion DNA polymerase binding surface; other site
478435000015	recF protein; Region: recf; TIGR00611
478435000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
478435000017	Walker A/P-loop; other site
478435000018	ATP binding site [chemical binding]; other site
478435000019	Q-loop/lid; other site
478435000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435000021	ABC transporter signature motif; other site
478435000022	Walker B; other site
478435000023	D-loop; other site
478435000024	H-loop/switch region; other site
478435000025	hypothetical protein; Provisional; Region: PRK03195
478435000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
478435000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435000028	Mg2+ binding site [ion binding]; other site
478435000029	G-X-G motif; other site
478435000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
478435000031	anchoring element; other site
478435000032	dimer interface [polypeptide binding]; other site
478435000033	ATP binding site [chemical binding]; other site
478435000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
478435000035	active site
478435000036	putative metal-binding site [ion binding]; other site
478435000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
478435000038	DNA gyrase subunit A; Validated; Region: PRK05560
478435000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
478435000040	CAP-like domain; other site
478435000041	active site
478435000042	primary dimer interface [polypeptide binding]; other site
478435000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
478435000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
478435000050	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
478435000051	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
478435000052	active site
478435000053	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
478435000054	putative septation inhibitor protein; Reviewed; Region: PRK00159
478435000055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
478435000056	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
478435000057	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
478435000058	Glutamine amidotransferase class-I; Region: GATase; pfam00117
478435000059	glutamine binding [chemical binding]; other site
478435000060	catalytic triad [active]
478435000061	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435000062	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435000063	active site
478435000064	ATP binding site [chemical binding]; other site
478435000065	substrate binding site [chemical binding]; other site
478435000066	activation loop (A-loop); other site
478435000067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
478435000068	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
478435000069	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
478435000070	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
478435000071	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
478435000072	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435000073	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435000074	active site
478435000075	ATP binding site [chemical binding]; other site
478435000076	substrate binding site [chemical binding]; other site
478435000077	activation loop (A-loop); other site
478435000078	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
478435000079	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
478435000080	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
478435000081	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
478435000082	active site
478435000083	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435000084	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435000085	phosphopeptide binding site; other site
478435000086	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
478435000087	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435000088	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435000089	phosphopeptide binding site; other site
478435000090	Nitronate monooxygenase; Region: NMO; pfam03060
478435000091	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
478435000092	FMN binding site [chemical binding]; other site
478435000093	substrate binding site [chemical binding]; other site
478435000094	putative catalytic residue [active]
478435000095	Transcription factor WhiB; Region: Whib; pfam02467
478435000096	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435000097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435000098	non-specific DNA binding site [nucleotide binding]; other site
478435000099	salt bridge; other site
478435000100	sequence-specific DNA binding site [nucleotide binding]; other site
478435000101	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
478435000102	NlpC/P60 family; Region: NLPC_P60; pfam00877
478435000103	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
478435000104	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
478435000105	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
478435000106	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
478435000107	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
478435000108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
478435000109	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
478435000110	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
478435000111	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435000112	catalytic residue [active]
478435000113	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
478435000114	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
478435000115	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
478435000116	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435000117	acyl-activating enzyme (AAE) consensus motif; other site
478435000118	active site
478435000119	TIGR03084 family protein; Region: TIGR03084
478435000120	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
478435000121	Wyosine base formation; Region: Wyosine_form; pfam08608
478435000122	H+ Antiporter protein; Region: 2A0121; TIGR00900
478435000123	hypothetical protein; Validated; Region: PRK00228
478435000124	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
478435000125	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
478435000126	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435000127	active site
478435000128	HIGH motif; other site
478435000129	nucleotide binding site [chemical binding]; other site
478435000130	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
478435000131	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435000132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435000133	active site
478435000134	KMSKS motif; other site
478435000135	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
478435000136	tRNA binding surface [nucleotide binding]; other site
478435000137	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435000138	MarR family; Region: MarR; pfam01047
478435000139	Transcriptional regulators [Transcription]; Region: FadR; COG2186
478435000140	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435000141	DNA-binding site [nucleotide binding]; DNA binding site
478435000142	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
478435000143	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435000144	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435000145	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
478435000146	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
478435000147	Predicted transcriptional regulators [Transcription]; Region: COG1695
478435000148	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
478435000149	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
478435000150	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
478435000151	Transglycosylase; Region: Transgly; pfam00912
478435000152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
478435000153	Predicted integral membrane protein [Function unknown]; Region: COG5650
478435000154	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
478435000155	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
478435000156	conserved cys residue [active]
478435000157	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
478435000158	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
478435000159	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
478435000160	dimer interface [polypeptide binding]; other site
478435000161	ssDNA binding site [nucleotide binding]; other site
478435000162	tetramer (dimer of dimers) interface [polypeptide binding]; other site
478435000163	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
478435000164	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
478435000165	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
478435000166	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
478435000167	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
478435000168	ADP-ribose binding site [chemical binding]; other site
478435000169	Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110
478435000170	Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297
478435000171	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
478435000172	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435000173	FAD binding domain; Region: FAD_binding_4; pfam01565
478435000174	Berberine and berberine like; Region: BBE; pfam08031
478435000175	hypothetical protein; Provisional; Region: PRK12438
478435000176	hypothetical protein; Validated; Region: PRK00068
478435000177	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
478435000178	homotetrameric interface [polypeptide binding]; other site
478435000179	putative active site [active]
478435000180	metal binding site [ion binding]; metal-binding site
478435000181	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
478435000182	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
478435000183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000185	short chain dehydrogenase; Provisional; Region: PRK06197
478435000186	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
478435000187	putative NAD(P) binding site [chemical binding]; other site
478435000188	active site
478435000189	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
478435000190	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
478435000191	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
478435000192	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
478435000193	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
478435000194	dimer interface [polypeptide binding]; other site
478435000195	active site
478435000196	glycine-pyridoxal phosphate binding site [chemical binding]; other site
478435000197	folate binding site [chemical binding]; other site
478435000198	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
478435000199	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
478435000200	putative NTP binding site [chemical binding]; other site
478435000201	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
478435000202	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
478435000203	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
478435000204	Walker A/P-loop; other site
478435000205	ATP binding site [chemical binding]; other site
478435000206	Q-loop/lid; other site
478435000207	ABC transporter signature motif; other site
478435000208	Walker B; other site
478435000209	D-loop; other site
478435000210	H-loop/switch region; other site
478435000211	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435000212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435000213	ligand binding site [chemical binding]; other site
478435000214	flexible hinge region; other site
478435000215	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
478435000216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
478435000217	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
478435000218	active site
478435000219	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
478435000220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435000221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435000222	homodimer interface [polypeptide binding]; other site
478435000223	catalytic residue [active]
478435000224	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435000225	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000226	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000227	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
478435000228	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435000229	dimerization interface [polypeptide binding]; other site
478435000230	putative DNA binding site [nucleotide binding]; other site
478435000231	putative Zn2+ binding site [ion binding]; other site
478435000232	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
478435000233	hydrogenase 4 subunit B; Validated; Region: PRK06521
478435000234	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
478435000235	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
478435000236	NADH dehydrogenase; Region: NADHdh; cl00469
478435000237	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237
478435000238	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
478435000239	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
478435000240	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
478435000241	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
478435000242	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
478435000243	putative hydrophobic ligand binding site [chemical binding]; other site
478435000244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000245	S-adenosylmethionine binding site [chemical binding]; other site
478435000246	Predicted membrane protein [Function unknown]; Region: COG3305
478435000247	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
478435000248	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
478435000249	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
478435000250	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
478435000251	metal-binding site [ion binding]
478435000252	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435000253	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435000254	Predicted integral membrane protein [Function unknown]; Region: COG5660
478435000255	Putative zinc-finger; Region: zf-HC2; pfam13490
478435000256	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435000257	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435000258	active site
478435000259	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435000260	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000261	PPE family; Region: PPE; pfam00823
478435000262	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
478435000263	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
478435000264	FcoT-like thioesterase domain; Region: FcoT; pfam10862
478435000265	acyl-CoA synthetase; Validated; Region: PRK05857
478435000266	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000267	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
478435000268	acyl-activating enzyme (AAE) consensus motif; other site
478435000269	acyl-activating enzyme (AAE) consensus motif; other site
478435000270	AMP binding site [chemical binding]; other site
478435000271	active site
478435000272	CoA binding site [chemical binding]; other site
478435000273	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435000274	AMP-binding enzyme; Region: AMP-binding; pfam00501
478435000275	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000276	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000277	acyl-activating enzyme (AAE) consensus motif; other site
478435000278	acyl-activating enzyme (AAE) consensus motif; other site
478435000279	active site
478435000280	AMP binding site [chemical binding]; other site
478435000281	CoA binding site [chemical binding]; other site
478435000282	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435000283	Condensation domain; Region: Condensation; pfam00668
478435000284	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435000285	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
478435000286	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
478435000287	acyl-activating enzyme (AAE) consensus motif; other site
478435000288	AMP binding site [chemical binding]; other site
478435000289	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435000290	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
478435000291	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
478435000292	putative NAD(P) binding site [chemical binding]; other site
478435000293	active site
478435000294	putative substrate binding site [chemical binding]; other site
478435000295	Predicted membrane protein [Function unknown]; Region: COG3336
478435000296	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
478435000297	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
478435000298	metal-binding site [ion binding]
478435000299	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435000300	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435000301	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435000302	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435000303	ligand binding site [chemical binding]; other site
478435000304	flexible hinge region; other site
478435000305	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
478435000306	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
478435000307	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
478435000308	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
478435000309	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435000310	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
478435000311	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435000312	motif II; other site
478435000313	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
478435000314	PE family; Region: PE; pfam00934
478435000315	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
478435000316	Rhomboid family; Region: Rhomboid; pfam01694
478435000317	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
478435000318	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
478435000319	active site
478435000320	catalytic triad [active]
478435000321	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435000322	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
478435000323	NADP-binding site; other site
478435000324	homotetramer interface [polypeptide binding]; other site
478435000325	substrate binding site [chemical binding]; other site
478435000326	homodimer interface [polypeptide binding]; other site
478435000327	active site
478435000328	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
478435000329	dimer interface [polypeptide binding]; other site
478435000330	active site
478435000331	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
478435000332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435000333	active site
478435000334	motif I; other site
478435000335	motif II; other site
478435000336	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
478435000337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
478435000338	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
478435000339	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
478435000340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
478435000341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
478435000342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
478435000343	dimerization interface [polypeptide binding]; other site
478435000344	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
478435000345	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
478435000346	PYR/PP interface [polypeptide binding]; other site
478435000347	dimer interface [polypeptide binding]; other site
478435000348	TPP binding site [chemical binding]; other site
478435000349	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
478435000350	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
478435000351	TPP-binding site; other site
478435000352	dimer interface [polypeptide binding]; other site
478435000353	acyl-CoA synthetase; Validated; Region: PRK05852
478435000354	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000355	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
478435000356	acyl-activating enzyme (AAE) consensus motif; other site
478435000357	acyl-activating enzyme (AAE) consensus motif; other site
478435000358	putative AMP binding site [chemical binding]; other site
478435000359	putative active site [active]
478435000360	putative CoA binding site [chemical binding]; other site
478435000361	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
478435000362	elongation factor G; Reviewed; Region: PRK12740
478435000363	G1 box; other site
478435000364	putative GEF interaction site [polypeptide binding]; other site
478435000365	GTP/Mg2+ binding site [chemical binding]; other site
478435000366	Switch I region; other site
478435000367	G2 box; other site
478435000368	G3 box; other site
478435000369	Switch II region; other site
478435000370	G4 box; other site
478435000371	G5 box; other site
478435000372	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
478435000373	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
478435000374	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
478435000375	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
478435000376	PE family; Region: PE; pfam00934
478435000377	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
478435000378	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
478435000379	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
478435000380	trehalose synthase; Region: treS_nterm; TIGR02456
478435000381	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
478435000382	active site
478435000383	catalytic site [active]
478435000384	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
478435000385	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
478435000386	Predicted membrane protein [Function unknown]; Region: COG3619
478435000387	Predicted esterase [General function prediction only]; Region: COG0627
478435000388	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
478435000389	putative active site [active]
478435000390	putative catalytic site [active]
478435000391	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435000392	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435000393	active site
478435000394	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
478435000395	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435000396	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
478435000397	Coenzyme A binding pocket [chemical binding]; other site
478435000398	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435000399	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
478435000400	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000401	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000402	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435000403	Cytochrome P450; Region: p450; cl12078
478435000404	methionine sulfoxide reductase A; Provisional; Region: PRK14054
478435000405	SnoaL-like domain; Region: SnoaL_2; pfam12680
478435000406	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
478435000407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435000408	NAD(P) binding site [chemical binding]; other site
478435000409	active site
478435000410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
478435000411	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
478435000412	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
478435000413	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
478435000414	minor groove reading motif; other site
478435000415	helix-hairpin-helix signature motif; other site
478435000416	active site
478435000417	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
478435000418	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
478435000419	Cl- selectivity filter; other site
478435000420	Cl- binding residues [ion binding]; other site
478435000421	pore gating glutamate residue; other site
478435000422	dimer interface [polypeptide binding]; other site
478435000423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000425	Leucine carboxyl methyltransferase; Region: LCM; cl01306
478435000426	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435000427	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435000428	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
478435000429	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
478435000430	NAD(P) binding site [chemical binding]; other site
478435000431	catalytic residues [active]
478435000432	short chain dehydrogenase; Provisional; Region: PRK07791
478435000433	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
478435000434	NAD binding site [chemical binding]; other site
478435000435	homodimer interface [polypeptide binding]; other site
478435000436	active site
478435000437	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
478435000438	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
478435000439	NAD(P) binding site [chemical binding]; other site
478435000440	PE family; Region: PE; pfam00934
478435000441	PE-PPE domain; Region: PE-PPE; pfam08237
478435000442	PE-PPE domain; Region: PE-PPE; pfam08237
478435000443	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
478435000444	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
478435000445	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
478435000446	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
478435000447	FAD binding site [chemical binding]; other site
478435000448	substrate binding site [chemical binding]; other site
478435000449	catalytic base [active]
478435000450	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
478435000451	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
478435000452	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
478435000453	ligand binding site [chemical binding]; other site
478435000454	homodimer interface [polypeptide binding]; other site
478435000455	NAD(P) binding site [chemical binding]; other site
478435000456	trimer interface B [polypeptide binding]; other site
478435000457	trimer interface A [polypeptide binding]; other site
478435000458	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
478435000459	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
478435000460	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
478435000461	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
478435000462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000464	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
478435000465	PE family; Region: PE; pfam00934
478435000466	PE-PPE domain; Region: PE-PPE; pfam08237
478435000467	PE family; Region: PE; pfam00934
478435000468	PE-PPE domain; Region: PE-PPE; pfam08237
478435000469	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435000470	FAD binding domain; Region: FAD_binding_4; pfam01565
478435000471	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
478435000472	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
478435000473	NAD(P) binding site [chemical binding]; other site
478435000474	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
478435000475	active site
478435000476	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
478435000477	putative hydrophobic ligand binding site [chemical binding]; other site
478435000478	Transcriptional regulators [Transcription]; Region: GntR; COG1802
478435000479	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435000480	DNA-binding site [nucleotide binding]; DNA binding site
478435000481	FCD domain; Region: FCD; pfam07729
478435000482	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
478435000483	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000484	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
478435000485	acyl-activating enzyme (AAE) consensus motif; other site
478435000486	acyl-activating enzyme (AAE) consensus motif; other site
478435000487	putative AMP binding site [chemical binding]; other site
478435000488	putative active site [active]
478435000489	putative CoA binding site [chemical binding]; other site
478435000490	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435000491	Permease; Region: Permease; pfam02405
478435000492	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435000493	Permease; Region: Permease; pfam02405
478435000494	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000495	mce related protein; Region: MCE; pfam02470
478435000496	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435000497	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000498	mce related protein; Region: MCE; pfam02470
478435000499	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435000500	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000501	mce related protein; Region: MCE; pfam02470
478435000502	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000503	mce related protein; Region: MCE; pfam02470
478435000504	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000505	mce related protein; Region: MCE; pfam02470
478435000506	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435000507	mce related protein; Region: MCE; pfam02470
478435000508	RDD family; Region: RDD; pfam06271
478435000509	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
478435000510	Predicted membrane protein [Function unknown]; Region: COG1511
478435000511	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
478435000512	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
478435000513	Pirin-related protein [General function prediction only]; Region: COG1741
478435000514	Pirin; Region: Pirin; pfam02678
478435000515	RNA polymerase factor sigma-70; Validated; Region: PRK08241
478435000516	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435000517	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435000518	DNA binding residues [nucleotide binding]
478435000519	SnoaL-like domain; Region: SnoaL_2; pfam12680
478435000520	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
478435000521	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435000522	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
478435000523	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
478435000524	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
478435000525	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
478435000526	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
478435000527	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
478435000528	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
478435000529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000530	S-adenosylmethionine binding site [chemical binding]; other site
478435000531	SPW repeat; Region: SPW; pfam03779
478435000532	SPW repeat; Region: SPW; pfam03779
478435000533	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
478435000534	6-phosphogluconate dehydratase; Region: edd; TIGR01196
478435000535	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
478435000536	putative homodimer interface [polypeptide binding]; other site
478435000537	putative homotetramer interface [polypeptide binding]; other site
478435000538	putative allosteric switch controlling residues; other site
478435000539	putative metal binding site [ion binding]; other site
478435000540	putative homodimer-homodimer interface [polypeptide binding]; other site
478435000541	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
478435000542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435000543	putative substrate translocation pore; other site
478435000544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
478435000545	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
478435000546	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
478435000547	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
478435000548	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
478435000549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435000550	Walker A/P-loop; other site
478435000551	ATP binding site [chemical binding]; other site
478435000552	Q-loop/lid; other site
478435000553	ABC transporter signature motif; other site
478435000554	Walker B; other site
478435000555	D-loop; other site
478435000556	H-loop/switch region; other site
478435000557	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
478435000558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435000559	Walker A/P-loop; other site
478435000560	ATP binding site [chemical binding]; other site
478435000561	Q-loop/lid; other site
478435000562	ABC transporter signature motif; other site
478435000563	Walker B; other site
478435000564	D-loop; other site
478435000565	H-loop/switch region; other site
478435000566	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435000567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435000568	dimerization interface [polypeptide binding]; other site
478435000569	DNA binding residues [nucleotide binding]
478435000570	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000571	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000572	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
478435000573	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
478435000574	putative [Fe4-S4] binding site [ion binding]; other site
478435000575	putative molybdopterin cofactor binding site [chemical binding]; other site
478435000576	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435000577	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
478435000578	putative molybdopterin cofactor binding site; other site
478435000579	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
478435000580	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
478435000581	active site
478435000582	Zn binding site [ion binding]; other site
478435000583	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435000584	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
478435000585	Predicted integral membrane protein [Function unknown]; Region: COG0392
478435000586	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
478435000587	Domain of unknown function DUF20; Region: UPF0118; pfam01594
478435000588	MMPL family; Region: MMPL; pfam03176
478435000589	MMPL family; Region: MMPL; pfam03176
478435000590	LabA_like proteins; Region: LabA_like/DUF88; cl10034
478435000591	putative metal binding site [ion binding]; other site
478435000592	Putative methyltransferase; Region: Methyltransf_4; pfam02390
478435000593	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
478435000594	active site
478435000595	substrate-binding site [chemical binding]; other site
478435000596	metal-binding site [ion binding]
478435000597	GTP binding site [chemical binding]; other site
478435000598	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
478435000599	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
478435000600	active site
478435000601	(T/H)XGH motif; other site
478435000602	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
478435000603	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
478435000604	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
478435000605	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435000606	FeS/SAM binding site; other site
478435000607	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
478435000608	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000609	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
478435000610	acyl-activating enzyme (AAE) consensus motif; other site
478435000611	acyl-activating enzyme (AAE) consensus motif; other site
478435000612	putative AMP binding site [chemical binding]; other site
478435000613	putative active site [active]
478435000614	putative CoA binding site [chemical binding]; other site
478435000615	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435000616	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435000617	active site
478435000618	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
478435000619	putative active site [active]
478435000620	putative catalytic site [active]
478435000621	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
478435000622	active site 2 [active]
478435000623	active site 1 [active]
478435000624	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435000625	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435000626	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
478435000627	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
478435000628	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
478435000629	Moco binding site; other site
478435000630	metal coordination site [ion binding]; other site
478435000631	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435000632	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435000633	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435000634	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435000635	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
478435000636	enoyl-CoA hydratase; Provisional; Region: PRK08252
478435000637	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435000638	substrate binding site [chemical binding]; other site
478435000639	oxyanion hole (OAH) forming residues; other site
478435000640	trimer interface [polypeptide binding]; other site
478435000641	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
478435000642	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
478435000643	NAD binding site [chemical binding]; other site
478435000644	catalytic residues [active]
478435000645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000646	S-adenosylmethionine binding site [chemical binding]; other site
478435000647	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
478435000648	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
478435000649	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
478435000650	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
478435000651	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435000652	putative active site [active]
478435000653	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
478435000654	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
478435000655	active site
478435000656	substrate binding pocket [chemical binding]; other site
478435000657	homodimer interaction site [polypeptide binding]; other site
478435000658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435000659	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
478435000660	active site
478435000661	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000662	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000663	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
478435000664	active site
478435000665	diiron metal binding site [ion binding]; other site
478435000666	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
478435000667	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
478435000668	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
478435000669	NAD(P) binding site [chemical binding]; other site
478435000670	catalytic residues [active]
478435000671	Lipase maturation factor; Region: LMF1; pfam06762
478435000672	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
478435000673	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
478435000674	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
478435000675	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
478435000676	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000677	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000678	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435000679	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
478435000680	MaoC like domain; Region: MaoC_dehydratas; pfam01575
478435000681	active site 2 [active]
478435000682	active site 1 [active]
478435000683	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
478435000684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435000685	NAD(P) binding site [chemical binding]; other site
478435000686	active site
478435000687	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
478435000688	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435000689	dimer interface [polypeptide binding]; other site
478435000690	active site
478435000691	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
478435000692	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
478435000693	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
478435000694	FAD binding site [chemical binding]; other site
478435000695	substrate binding site [chemical binding]; other site
478435000696	catalytic residues [active]
478435000697	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
478435000698	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
478435000699	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
478435000700	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435000701	catalytic loop [active]
478435000702	iron binding site [ion binding]; other site
478435000703	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
478435000704	L-aspartate oxidase; Provisional; Region: PRK06175
478435000705	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
478435000706	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
478435000707	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
478435000708	putative dimer interface [polypeptide binding]; other site
478435000709	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
478435000710	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435000711	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
478435000712	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
478435000713	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
478435000714	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
478435000715	homotrimer interface [polypeptide binding]; other site
478435000716	Walker A motif; other site
478435000717	GTP binding site [chemical binding]; other site
478435000718	Walker B motif; other site
478435000719	cobyric acid synthase; Provisional; Region: PRK00784
478435000720	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
478435000721	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
478435000722	catalytic triad [active]
478435000723	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000724	PPE family; Region: PPE; pfam00823
478435000725	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
478435000726	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
478435000727	putative active site [active]
478435000728	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
478435000729	putative active site [active]
478435000730	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
478435000731	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
478435000732	active site
478435000733	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
478435000734	DNA binding site [nucleotide binding]
478435000735	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
478435000736	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435000737	Coenzyme A binding pocket [chemical binding]; other site
478435000738	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
478435000739	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
478435000740	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
478435000741	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
478435000742	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
478435000743	intersubunit interface [polypeptide binding]; other site
478435000744	5-oxoprolinase; Region: PLN02666
478435000745	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
478435000746	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
478435000747	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
478435000748	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
478435000749	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
478435000750	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
478435000751	nucleotide binding site [chemical binding]; other site
478435000752	acyl-CoA synthetase; Validated; Region: PRK07788
478435000753	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000754	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435000755	active site
478435000756	CoA binding site [chemical binding]; other site
478435000757	AMP binding site [chemical binding]; other site
478435000758	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435000759	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435000760	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
478435000761	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435000762	FAD binding site [chemical binding]; other site
478435000763	substrate binding site [chemical binding]; other site
478435000764	catalytic base [active]
478435000765	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
478435000766	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000767	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000768	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
478435000769	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435000770	Zn binding site [ion binding]; other site
478435000771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
478435000772	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435000773	putative active site [active]
478435000774	PE family; Region: PE; pfam00934
478435000775	PE family; Region: PE; pfam00934
478435000776	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000777	PPE family; Region: PPE; pfam00823
478435000778	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000779	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435000780	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435000781	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
478435000782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435000783	Walker A motif; other site
478435000784	ATP binding site [chemical binding]; other site
478435000785	Walker B motif; other site
478435000786	arginine finger; other site
478435000787	Protein of unknown function (DUF690); Region: DUF690; pfam05108
478435000788	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
478435000789	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435000790	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
478435000791	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435000792	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435000793	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000794	PPE family; Region: PPE; pfam00823
478435000795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435000796	EspG family; Region: ESX-1_EspG; pfam14011
478435000797	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
478435000798	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435000799	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
478435000800	active site
478435000801	catalytic residues [active]
478435000802	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
478435000803	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
478435000804	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
478435000805	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
478435000806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000807	S-adenosylmethionine binding site [chemical binding]; other site
478435000808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
478435000809	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
478435000810	Sulfatase; Region: Sulfatase; cl17466
478435000811	hypothetical protein; Region: PHA01748
478435000812	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435000813	putative active site [active]
478435000814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000816	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
478435000817	protochlorophyllide reductase; Region: PLN00015
478435000818	putative NAD(P) binding site [chemical binding]; other site
478435000819	active site
478435000820	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000821	PPE family; Region: PPE; pfam00823
478435000822	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000823	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000824	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000825	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000826	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000827	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000828	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000829	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000830	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000831	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000832	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000833	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000834	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
478435000835	putative FMN binding site [chemical binding]; other site
478435000836	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
478435000837	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
478435000838	active site
478435000839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
478435000840	SnoaL-like domain; Region: SnoaL_4; pfam13577
478435000841	SnoaL-like domain; Region: SnoaL_3; pfam13474
478435000842	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
478435000843	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435000844	nucleotide binding site [chemical binding]; other site
478435000845	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
478435000846	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
478435000847	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
478435000848	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
478435000849	active site
478435000850	catalytic residues [active]
478435000851	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
478435000852	Muconolactone delta-isomerase; Region: MIase; cl01992
478435000853	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
478435000854	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
478435000855	putative active site [active]
478435000856	catalytic site [active]
478435000857	putative metal binding site [ion binding]; other site
478435000858	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
478435000859	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
478435000860	putative substrate binding pocket [chemical binding]; other site
478435000861	AC domain interface; other site
478435000862	catalytic triad [active]
478435000863	AB domain interface; other site
478435000864	interchain disulfide; other site
478435000865	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
478435000866	trimer interface [polypeptide binding]; other site
478435000867	active site
478435000868	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
478435000869	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
478435000870	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
478435000871	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
478435000872	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
478435000873	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435000874	dimerization interface [polypeptide binding]; other site
478435000875	putative DNA binding site [nucleotide binding]; other site
478435000876	putative Zn2+ binding site [ion binding]; other site
478435000877	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
478435000878	active site residue [active]
478435000879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000880	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435000881	Cytochrome P450; Region: p450; cl12078
478435000882	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
478435000883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000884	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
478435000885	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435000886	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435000887	S-adenosylmethionine binding site [chemical binding]; other site
478435000888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435000889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435000890	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
478435000891	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435000892	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
478435000893	SnoaL-like domain; Region: SnoaL_2; pfam12680
478435000894	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
478435000895	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
478435000896	substrate binding site; other site
478435000897	tetramer interface; other site
478435000898	PE family; Region: PE; pfam00934
478435000899	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435000900	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435000901	active site
478435000902	aminotransferase AlaT; Validated; Region: PRK09265
478435000903	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435000904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435000905	homodimer interface [polypeptide binding]; other site
478435000906	catalytic residue [active]
478435000907	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
478435000908	4Fe-4S binding domain; Region: Fer4; pfam00037
478435000909	Cysteine-rich domain; Region: CCG; pfam02754
478435000910	Cysteine-rich domain; Region: CCG; pfam02754
478435000911	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435000912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435000913	DNA binding residues [nucleotide binding]
478435000914	dimerization interface [polypeptide binding]; other site
478435000915	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
478435000916	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
478435000917	G1 box; other site
478435000918	GTP/Mg2+ binding site [chemical binding]; other site
478435000919	G2 box; other site
478435000920	Switch I region; other site
478435000921	G3 box; other site
478435000922	Switch II region; other site
478435000923	G4 box; other site
478435000924	G5 box; other site
478435000925	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
478435000926	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
478435000927	G1 box; other site
478435000928	GTP/Mg2+ binding site [chemical binding]; other site
478435000929	G2 box; other site
478435000930	Switch I region; other site
478435000931	G3 box; other site
478435000932	Switch II region; other site
478435000933	Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068
478435000934	active site
478435000935	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
478435000936	TIGR04255 family protein; Region: sporadTIGR04255
478435000937	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
478435000938	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
478435000939	nucleotide binding site [chemical binding]; other site
478435000940	NEF interaction site [polypeptide binding]; other site
478435000941	SBD interface [polypeptide binding]; other site
478435000942	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
478435000943	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
478435000944	dimer interface [polypeptide binding]; other site
478435000945	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
478435000946	chaperone protein DnaJ; Provisional; Region: PRK14279
478435000947	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
478435000948	HSP70 interaction site [polypeptide binding]; other site
478435000949	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
478435000950	Zn binding sites [ion binding]; other site
478435000951	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
478435000952	dimer interface [polypeptide binding]; other site
478435000953	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
478435000954	DNA binding residues [nucleotide binding]
478435000955	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
478435000956	putative dimer interface [polypeptide binding]; other site
478435000957	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000958	PPE family; Region: PPE; pfam00823
478435000959	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435000960	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000961	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000962	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435000963	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
478435000964	CoenzymeA binding site [chemical binding]; other site
478435000965	subunit interaction site [polypeptide binding]; other site
478435000966	PHB binding site; other site
478435000967	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
478435000968	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
478435000969	GDP-binding site [chemical binding]; other site
478435000970	ACT binding site; other site
478435000971	IMP binding site; other site
478435000972	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
478435000973	Peptidase family M50; Region: Peptidase_M50; pfam02163
478435000974	active site
478435000975	putative substrate binding region [chemical binding]; other site
478435000976	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
478435000977	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
478435000978	MgtE intracellular N domain; Region: MgtE_N; pfam03448
478435000979	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
478435000980	Divalent cation transporter; Region: MgtE; pfam01769
478435000981	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
478435000982	fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520
478435000983	active site
478435000984	intersubunit interface [polypeptide binding]; other site
478435000985	zinc binding site [ion binding]; other site
478435000986	Na+ binding site [ion binding]; other site
478435000987	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
478435000988	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
478435000989	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
478435000990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
478435000991	AAA domain; Region: AAA_33; pfam13671
478435000992	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
478435000993	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
478435000994	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
478435000995	putative hydrophobic ligand binding site [chemical binding]; other site
478435000996	MoxR-like ATPases [General function prediction only]; Region: COG0714
478435000997	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
478435000998	Ligand binding site; other site
478435000999	metal-binding site
478435001000	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
478435001001	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
478435001002	XdhC Rossmann domain; Region: XdhC_C; pfam13478
478435001003	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
478435001004	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
478435001005	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
478435001006	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
478435001007	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435001008	catalytic loop [active]
478435001009	iron binding site [ion binding]; other site
478435001010	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
478435001011	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
478435001012	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
478435001013	Uncharacterized conserved protein [Function unknown]; Region: COG3360
478435001014	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
478435001015	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
478435001016	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435001017	active site
478435001018	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
478435001019	Clp amino terminal domain; Region: Clp_N; pfam02861
478435001020	Clp amino terminal domain; Region: Clp_N; pfam02861
478435001021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435001022	Walker A motif; other site
478435001023	ATP binding site [chemical binding]; other site
478435001024	Walker B motif; other site
478435001025	arginine finger; other site
478435001026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435001027	Walker A motif; other site
478435001028	ATP binding site [chemical binding]; other site
478435001029	Walker B motif; other site
478435001030	arginine finger; other site
478435001031	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
478435001032	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
478435001033	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
478435001034	heme-binding site [chemical binding]; other site
478435001035	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
478435001036	FAD binding pocket [chemical binding]; other site
478435001037	FAD binding motif [chemical binding]; other site
478435001038	phosphate binding motif [ion binding]; other site
478435001039	beta-alpha-beta structure motif; other site
478435001040	NAD binding pocket [chemical binding]; other site
478435001041	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435001042	cyclase homology domain; Region: CHD; cd07302
478435001043	nucleotidyl binding site; other site
478435001044	metal binding site [ion binding]; metal-binding site
478435001045	dimer interface [polypeptide binding]; other site
478435001046	Predicted ATPase [General function prediction only]; Region: COG3903
478435001047	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
478435001048	Walker A motif; other site
478435001049	ATP binding site [chemical binding]; other site
478435001050	Walker B motif; other site
478435001051	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435001052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435001053	DNA binding residues [nucleotide binding]
478435001054	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435001055	PPE family; Region: PPE; pfam00823
478435001056	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
478435001057	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435001058	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
478435001059	active site residue [active]
478435001060	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
478435001061	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
478435001062	homodimer interface [polypeptide binding]; other site
478435001063	substrate-cofactor binding pocket; other site
478435001064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435001065	catalytic residue [active]
478435001066	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
478435001067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435001068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435001069	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435001070	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435001071	active site
478435001072	PLD-like domain; Region: PLDc_2; pfam13091
478435001073	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435001074	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435001075	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
478435001076	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435001077	FAD binding site [chemical binding]; other site
478435001078	substrate binding pocket [chemical binding]; other site
478435001079	catalytic base [active]
478435001080	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
478435001081	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435001082	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
478435001083	acyl-CoA synthetase; Validated; Region: PRK05850
478435001084	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435001085	acyl-activating enzyme (AAE) consensus motif; other site
478435001086	active site
478435001087	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
478435001088	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435001089	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
478435001090	active site
478435001091	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435001092	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435001093	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435001094	Thioesterase; Region: PKS_TE; smart00824
478435001095	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
478435001096	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
478435001097	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
478435001098	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435001099	phosphate acetyltransferase; Reviewed; Region: PRK05632
478435001100	DRTGG domain; Region: DRTGG; pfam07085
478435001101	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
478435001102	propionate/acetate kinase; Provisional; Region: PRK12379
478435001103	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
478435001104	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435001105	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435001106	active site
478435001107	ATP binding site [chemical binding]; other site
478435001108	substrate binding site [chemical binding]; other site
478435001109	activation loop (A-loop); other site
478435001110	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
478435001111	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
478435001112	substrate binding pocket [chemical binding]; other site
478435001113	membrane-bound complex binding site; other site
478435001114	hinge residues; other site
478435001115	NUDIX domain; Region: NUDIX; pfam00293
478435001116	nudix motif; other site
478435001117	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
478435001118	thiamine phosphate binding site [chemical binding]; other site
478435001119	active site
478435001120	pyrophosphate binding site [ion binding]; other site
478435001121	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
478435001122	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
478435001123	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
478435001124	thiS-thiF/thiG interaction site; other site
478435001125	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
478435001126	ThiS interaction site; other site
478435001127	putative active site [active]
478435001128	tetramer interface [polypeptide binding]; other site
478435001129	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
478435001130	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
478435001131	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
478435001132	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
478435001133	PA/protease or protease-like domain interface [polypeptide binding]; other site
478435001134	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
478435001135	active site
478435001136	metal binding site [ion binding]; metal-binding site
478435001137	Predicted metalloprotease [General function prediction only]; Region: COG2321
478435001138	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
478435001139	Zn binding site [ion binding]; other site
478435001140	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
478435001141	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
478435001142	dimer interface [polypeptide binding]; other site
478435001143	substrate binding site [chemical binding]; other site
478435001144	ATP binding site [chemical binding]; other site
478435001145	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
478435001146	ThiC-associated domain; Region: ThiC-associated; pfam13667
478435001147	ThiC family; Region: ThiC; pfam01964
478435001148	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435001149	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
478435001150	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435001151	motif II; other site
478435001152	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
478435001153	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
478435001154	putative catalytic site [active]
478435001155	putative phosphate binding site [ion binding]; other site
478435001156	active site
478435001157	metal binding site A [ion binding]; metal-binding site
478435001158	DNA binding site [nucleotide binding]
478435001159	putative AP binding site [nucleotide binding]; other site
478435001160	putative metal binding site B [ion binding]; other site
478435001161	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
478435001162	active site
478435001163	catalytic residues [active]
478435001164	metal binding site [ion binding]; metal-binding site
478435001165	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
478435001166	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
478435001167	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
478435001168	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
478435001169	E-class dimer interface [polypeptide binding]; other site
478435001170	P-class dimer interface [polypeptide binding]; other site
478435001171	active site
478435001172	Cu2+ binding site [ion binding]; other site
478435001173	Zn2+ binding site [ion binding]; other site
478435001174	carboxylate-amine ligase; Provisional; Region: PRK13517
478435001175	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
478435001176	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
478435001177	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
478435001178	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
478435001179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435001180	Walker A motif; other site
478435001181	ATP binding site [chemical binding]; other site
478435001182	Walker B motif; other site
478435001183	arginine finger; other site
478435001184	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435001185	Walker A motif; other site
478435001186	ATP binding site [chemical binding]; other site
478435001187	Walker B motif; other site
478435001188	arginine finger; other site
478435001189	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
478435001190	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
478435001191	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
478435001192	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
478435001193	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
478435001194	dimer interface [polypeptide binding]; other site
478435001195	putative functional site; other site
478435001196	putative MPT binding site; other site
478435001197	short chain dehydrogenase; Provisional; Region: PRK06197
478435001198	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
478435001199	putative NAD(P) binding site [chemical binding]; other site
478435001200	active site
478435001201	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
478435001202	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
478435001203	ring oligomerisation interface [polypeptide binding]; other site
478435001204	ATP/Mg binding site [chemical binding]; other site
478435001205	stacking interactions; other site
478435001206	hinge regions; other site
478435001207	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435001208	PPE family; Region: PPE; pfam00823
478435001209	Protein of unknown function (DUF664); Region: DUF664; pfam04978
478435001210	DinB superfamily; Region: DinB_2; pfam12867
478435001211	putative anti-sigmaE protein; Provisional; Region: PRK13920
478435001212	Anti-sigma-K factor rskA; Region: RskA; pfam10099
478435001213	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
478435001214	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435001215	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435001216	DNA binding residues [nucleotide binding]
478435001217	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001218	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001219	S-adenosylmethionine binding site [chemical binding]; other site
478435001220	Uncharacterized conserved protein [Function unknown]; Region: COG3496
478435001221	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
478435001222	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
478435001223	dimer interface [polypeptide binding]; other site
478435001224	Transport protein; Region: actII; TIGR00833
478435001225	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
478435001226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435001227	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435001228	PPE family; Region: PPE; pfam00823
478435001229	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435001230	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
478435001231	enoyl-CoA hydratase; Provisional; Region: PRK12478
478435001232	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435001233	substrate binding site [chemical binding]; other site
478435001234	oxyanion hole (OAH) forming residues; other site
478435001235	trimer interface [polypeptide binding]; other site
478435001236	PemK-like protein; Region: PemK; pfam02452
478435001237	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
478435001238	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435001239	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
478435001240	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
478435001241	NAD(P) binding site [chemical binding]; other site
478435001242	catalytic residues [active]
478435001243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
478435001244	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
478435001245	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
478435001246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435001247	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
478435001248	Uncharacterized conserved protein [Function unknown]; Region: COG2128
478435001249	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
478435001250	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435001251	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435001252	non-specific DNA binding site [nucleotide binding]; other site
478435001253	salt bridge; other site
478435001254	sequence-specific DNA binding site [nucleotide binding]; other site
478435001255	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
478435001256	Domain of unknown function (DUF955); Region: DUF955; pfam06114
478435001257	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
478435001258	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
478435001259	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
478435001260	active site
478435001261	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
478435001262	active site 2 [active]
478435001263	isocitrate lyase; Provisional; Region: PRK15063
478435001264	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556
478435001265	oligomerization interface [polypeptide binding]; other site
478435001266	active site
478435001267	metal binding site [ion binding]; metal-binding site
478435001268	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
478435001269	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
478435001270	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
478435001271	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001273	S-adenosylmethionine binding site [chemical binding]; other site
478435001274	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435001276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001277	S-adenosylmethionine binding site [chemical binding]; other site
478435001278	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
478435001279	UbiA prenyltransferase family; Region: UbiA; pfam01040
478435001280	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435001281	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435001282	Predicted membrane protein [Function unknown]; Region: COG2733
478435001283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435001284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435001285	non-specific DNA binding site [nucleotide binding]; other site
478435001286	salt bridge; other site
478435001287	sequence-specific DNA binding site [nucleotide binding]; other site
478435001288	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
478435001289	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
478435001290	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
478435001291	intersubunit interface [polypeptide binding]; other site
478435001292	active site
478435001293	catalytic residue [active]
478435001294	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
478435001295	Predicted amidohydrolase [General function prediction only]; Region: COG0388
478435001296	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
478435001297	putative active site [active]
478435001298	catalytic triad [active]
478435001299	putative dimer interface [polypeptide binding]; other site
478435001300	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
478435001301	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
478435001302	FAD binding domain; Region: FAD_binding_4; pfam01565
478435001303	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
478435001304	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
478435001305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
478435001306	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
478435001307	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
478435001308	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
478435001309	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435001310	NAD(P) binding site [chemical binding]; other site
478435001311	active site
478435001312	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
478435001313	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435001314	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
478435001315	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
478435001316	putative ADP-binding pocket [chemical binding]; other site
478435001317	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
478435001318	L-lysine exporter; Region: 2a75; TIGR00948
478435001319	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435001320	catalytic core [active]
478435001321	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
478435001322	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435001323	dimer interface [polypeptide binding]; other site
478435001324	phosphorylation site [posttranslational modification]
478435001325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435001326	ATP binding site [chemical binding]; other site
478435001327	Mg2+ binding site [ion binding]; other site
478435001328	G-X-G motif; other site
478435001329	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435001330	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435001331	active site
478435001332	phosphorylation site [posttranslational modification]
478435001333	intermolecular recognition site; other site
478435001334	dimerization interface [polypeptide binding]; other site
478435001335	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435001336	DNA binding site [nucleotide binding]
478435001337	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
478435001338	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
478435001339	Transcriptional regulators [Transcription]; Region: FadR; COG2186
478435001340	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435001341	DNA-binding site [nucleotide binding]; DNA binding site
478435001342	FCD domain; Region: FCD; pfam07729
478435001343	exopolyphosphatase; Region: exo_poly_only; TIGR03706
478435001344	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
478435001345	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
478435001346	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
478435001347	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
478435001348	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
478435001349	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
478435001350	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
478435001351	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
478435001352	DNA binding domain, excisionase family; Region: excise; TIGR01764
478435001353	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435001354	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
478435001355	putative NAD(P) binding site [chemical binding]; other site
478435001356	active site
478435001357	putative substrate binding site [chemical binding]; other site
478435001358	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435001359	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
478435001360	putative acyl-acceptor binding pocket; other site
478435001361	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435001363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001364	S-adenosylmethionine binding site [chemical binding]; other site
478435001365	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
478435001366	active site
478435001367	catalytic site [active]
478435001368	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
478435001369	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
478435001370	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
478435001371	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435001372	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
478435001373	glutamyl-tRNA reductase; Region: hemA; TIGR01035
478435001374	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
478435001375	tRNA; other site
478435001376	putative tRNA binding site [nucleotide binding]; other site
478435001377	putative NADP binding site [chemical binding]; other site
478435001378	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
478435001379	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
478435001380	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
478435001381	domain interfaces; other site
478435001382	active site
478435001383	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
478435001384	active site
478435001385	homodimer interface [polypeptide binding]; other site
478435001386	SAM binding site [chemical binding]; other site
478435001387	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
478435001388	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
478435001389	active site
478435001390	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
478435001391	dimer interface [polypeptide binding]; other site
478435001392	active site
478435001393	Schiff base residues; other site
478435001394	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435001395	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435001396	active site
478435001397	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435001398	anti sigma factor interaction site; other site
478435001399	regulatory phosphorylation site [posttranslational modification]; other site
478435001400	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
478435001401	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
478435001402	active site
478435001403	catalytic triad [active]
478435001404	oxyanion hole [active]
478435001405	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
478435001406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001407	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435001408	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
478435001409	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435001410	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
478435001411	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435001412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435001413	catalytic residue [active]
478435001414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435001415	catalytic core [active]
478435001416	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
478435001417	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435001418	catalytic residues [active]
478435001419	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
478435001420	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
478435001421	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
478435001422	ResB-like family; Region: ResB; pfam05140
478435001423	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
478435001424	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435001425	AAA domain; Region: AAA_31; pfam13614
478435001426	P-loop; other site
478435001427	Magnesium ion binding site [ion binding]; other site
478435001428	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
478435001429	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
478435001430	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
478435001431	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
478435001432	dimer interface [polypeptide binding]; other site
478435001433	active site
478435001434	CoA binding pocket [chemical binding]; other site
478435001435	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
478435001436	UbiA prenyltransferase family; Region: UbiA; pfam01040
478435001437	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
478435001438	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435001439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435001440	NAD(P) binding site [chemical binding]; other site
478435001441	active site
478435001442	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
478435001443	Ligand binding site; other site
478435001444	Putative Catalytic site; other site
478435001445	DXD motif; other site
478435001446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
478435001447	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
478435001448	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435001449	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435001450	acyl-activating enzyme (AAE) consensus motif; other site
478435001451	acyl-activating enzyme (AAE) consensus motif; other site
478435001452	AMP binding site [chemical binding]; other site
478435001453	active site
478435001454	CoA binding site [chemical binding]; other site
478435001455	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
478435001456	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
478435001457	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435001458	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
478435001459	active site
478435001460	short chain dehydrogenase; Provisional; Region: PRK05866
478435001461	classical (c) SDRs; Region: SDR_c; cd05233
478435001462	NAD(P) binding site [chemical binding]; other site
478435001463	active site
478435001464	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435001465	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
478435001466	substrate binding site [chemical binding]; other site
478435001467	oxyanion hole (OAH) forming residues; other site
478435001468	trimer interface [polypeptide binding]; other site
478435001469	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
478435001470	putative active site [active]
478435001471	homotetrameric interface [polypeptide binding]; other site
478435001472	metal binding site [ion binding]; metal-binding site
478435001473	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
478435001474	acyl-CoA synthetase; Validated; Region: PRK06188
478435001475	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
478435001476	putative active site [active]
478435001477	putative CoA binding site [chemical binding]; other site
478435001478	putative AMP binding site [chemical binding]; other site
478435001479	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
478435001480	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
478435001481	active site
478435001482	O-succinylbenzoate synthase; Provisional; Region: PRK02901
478435001483	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
478435001484	active site
478435001485	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435001486	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
478435001487	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435001488	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
478435001489	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
478435001490	dimer interface [polypeptide binding]; other site
478435001491	tetramer interface [polypeptide binding]; other site
478435001492	PYR/PP interface [polypeptide binding]; other site
478435001493	TPP binding site [chemical binding]; other site
478435001494	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
478435001495	TPP-binding site; other site
478435001496	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
478435001497	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
478435001498	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
478435001499	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
478435001500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001501	S-adenosylmethionine binding site [chemical binding]; other site
478435001502	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435001503	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435001504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001505	S-adenosylmethionine binding site [chemical binding]; other site
478435001506	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
478435001507	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
478435001508	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
478435001509	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
478435001510	substrate binding pocket [chemical binding]; other site
478435001511	chain length determination region; other site
478435001512	substrate-Mg2+ binding site; other site
478435001513	catalytic residues [active]
478435001514	aspartate-rich region 1; other site
478435001515	active site lid residues [active]
478435001516	aspartate-rich region 2; other site
478435001517	heat shock protein HtpX; Provisional; Region: PRK03072
478435001518	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
478435001519	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
478435001520	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
478435001521	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435001522	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435001523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
478435001524	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
478435001525	O-methyltransferase; Region: Methyltransf_2; pfam00891
478435001526	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435001527	Cytochrome P450; Region: p450; cl12078
478435001528	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
478435001529	ATP cone domain; Region: ATP-cone; pfam03477
478435001530	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
478435001531	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
478435001532	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
478435001533	active site
478435001534	dimer interface [polypeptide binding]; other site
478435001535	effector binding site; other site
478435001536	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
478435001537	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435001538	active site
478435001539	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435001540	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
478435001541	nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484
478435001542	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
478435001543	active site
478435001544	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
478435001545	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
478435001546	putative active site [active]
478435001547	putative metal binding site [ion binding]; other site
478435001548	hypothetical protein; Provisional; Region: PRK07588
478435001549	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
478435001550	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435001551	dimerization interface [polypeptide binding]; other site
478435001552	putative DNA binding site [nucleotide binding]; other site
478435001553	putative Zn2+ binding site [ion binding]; other site
478435001554	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
478435001555	putative hydrophobic ligand binding site [chemical binding]; other site
478435001556	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435001557	TIGR03086 family protein; Region: TIGR03086
478435001558	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
478435001559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435001560	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
478435001561	PE family; Region: PE; pfam00934
478435001562	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
478435001563	Uncharacterized conserved protein [Function unknown]; Region: COG1656
478435001564	Protein of unknown function DUF82; Region: DUF82; pfam01927
478435001565	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435001566	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435001567	putative active site [active]
478435001568	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
478435001569	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
478435001570	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
478435001571	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
478435001572	Transcriptional regulators [Transcription]; Region: FadR; COG2186
478435001573	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435001574	DNA-binding site [nucleotide binding]; DNA binding site
478435001575	FCD domain; Region: FCD; pfam07729
478435001576	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435001577	Permease; Region: Permease; pfam02405
478435001578	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435001579	Permease; Region: Permease; pfam02405
478435001580	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435001581	mce related protein; Region: MCE; pfam02470
478435001582	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435001583	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
478435001584	mce related protein; Region: MCE; pfam02470
478435001585	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435001586	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435001587	mce related protein; Region: MCE; pfam02470
478435001588	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435001589	mce related protein; Region: MCE; pfam02470
478435001590	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435001591	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435001592	mce related protein; Region: MCE; pfam02470
478435001593	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435001594	mce related protein; Region: MCE; pfam02470
478435001595	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
478435001596	oligomeric interface; other site
478435001597	putative active site [active]
478435001598	homodimer interface [polypeptide binding]; other site
478435001599	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435001600	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
478435001601	AAA domain; Region: AAA_14; pfam13173
478435001602	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
478435001603	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
478435001604	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435001605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435001606	ATP binding site [chemical binding]; other site
478435001607	Mg2+ binding site [ion binding]; other site
478435001608	G-X-G motif; other site
478435001609	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435001610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435001611	active site
478435001612	phosphorylation site [posttranslational modification]
478435001613	intermolecular recognition site; other site
478435001614	dimerization interface [polypeptide binding]; other site
478435001615	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435001616	DNA binding site [nucleotide binding]
478435001617	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
478435001618	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
478435001619	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435001620	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
478435001621	catalytic residues [active]
478435001622	catalytic nucleophile [active]
478435001623	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
478435001624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435001625	Probable transposase; Region: OrfB_IS605; pfam01385
478435001626	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
478435001627	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
478435001628	putative active site [active]
478435001629	SEC-C motif; Region: SEC-C; pfam02810
478435001630	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
478435001631	putative active site [active]
478435001632	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
478435001633	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
478435001634	nucleotide binding site/active site [active]
478435001635	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
478435001636	galactokinase; Provisional; Region: PRK00555
478435001637	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
478435001638	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435001639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
478435001640	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
478435001641	putative active site [active]
478435001642	Uncharacterized conserved protein [Function unknown]; Region: COG0398
478435001643	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
478435001644	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435001645	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
478435001646	oligomeric interface; other site
478435001647	putative active site [active]
478435001648	homodimer interface [polypeptide binding]; other site
478435001649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
478435001650	FIST N domain; Region: FIST; pfam08495
478435001651	FIST C domain; Region: FIST_C; pfam10442
478435001652	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
478435001653	AAA domain; Region: AAA_30; pfam13604
478435001654	Family description; Region: UvrD_C_2; pfam13538
478435001655	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
478435001656	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
478435001657	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
478435001658	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
478435001659	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435001660	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435001661	substrate binding site [chemical binding]; other site
478435001662	oxyanion hole (OAH) forming residues; other site
478435001663	trimer interface [polypeptide binding]; other site
478435001664	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
478435001665	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435001666	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
478435001667	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
478435001668	active site
478435001669	catalytic site [active]
478435001670	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
478435001671	active site
478435001672	catalytic site [active]
478435001673	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
478435001674	active site
478435001675	catalytic site [active]
478435001676	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
478435001677	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
478435001678	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
478435001679	putative homodimer interface [polypeptide binding]; other site
478435001680	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
478435001681	heterodimer interface [polypeptide binding]; other site
478435001682	homodimer interface [polypeptide binding]; other site
478435001683	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
478435001684	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
478435001685	23S rRNA interface [nucleotide binding]; other site
478435001686	L7/L12 interface [polypeptide binding]; other site
478435001687	putative thiostrepton binding site; other site
478435001688	L25 interface [polypeptide binding]; other site
478435001689	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
478435001690	mRNA/rRNA interface [nucleotide binding]; other site
478435001691	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001693	S-adenosylmethionine binding site [chemical binding]; other site
478435001694	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435001696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001697	S-adenosylmethionine binding site [chemical binding]; other site
478435001698	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435001700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001701	S-adenosylmethionine binding site [chemical binding]; other site
478435001702	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435001703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435001704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435001705	S-adenosylmethionine binding site [chemical binding]; other site
478435001706	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435001707	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435001708	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
478435001709	ABC1 family; Region: ABC1; cl17513
478435001710	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
478435001711	active site
478435001712	catalytic site [active]
478435001713	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
478435001714	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
478435001715	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
478435001716	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
478435001717	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435001718	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
478435001719	23S rRNA interface [nucleotide binding]; other site
478435001720	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
478435001721	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
478435001722	core dimer interface [polypeptide binding]; other site
478435001723	peripheral dimer interface [polypeptide binding]; other site
478435001724	L10 interface [polypeptide binding]; other site
478435001725	L11 interface [polypeptide binding]; other site
478435001726	putative EF-Tu interaction site [polypeptide binding]; other site
478435001727	putative EF-G interaction site [polypeptide binding]; other site
478435001728	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435001729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435001730	WHG domain; Region: WHG; pfam13305
478435001731	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
478435001732	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
478435001733	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
478435001734	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
478435001735	Walker A/P-loop; other site
478435001736	ATP binding site [chemical binding]; other site
478435001737	Q-loop/lid; other site
478435001738	ABC transporter signature motif; other site
478435001739	Walker B; other site
478435001740	D-loop; other site
478435001741	H-loop/switch region; other site
478435001742	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
478435001743	putative active site [active]
478435001744	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435001745	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
478435001746	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435001747	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
478435001748	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
478435001749	Sulfatase; Region: Sulfatase; pfam00884
478435001750	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
478435001751	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
478435001752	putative active site [active]
478435001753	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
478435001754	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
478435001755	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
478435001756	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
478435001757	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
478435001758	RPB10 interaction site [polypeptide binding]; other site
478435001759	RPB1 interaction site [polypeptide binding]; other site
478435001760	RPB11 interaction site [polypeptide binding]; other site
478435001761	RPB3 interaction site [polypeptide binding]; other site
478435001762	RPB12 interaction site [polypeptide binding]; other site
478435001763	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
478435001764	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
478435001765	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
478435001766	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
478435001767	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
478435001768	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
478435001769	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
478435001770	G-loop; other site
478435001771	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
478435001772	DNA binding site [nucleotide binding]
478435001773	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
478435001774	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
478435001775	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
478435001776	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
478435001777	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
478435001778	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435001779	active site
478435001780	enoyl-CoA hydratase; Provisional; Region: PRK12478
478435001781	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435001782	substrate binding site [chemical binding]; other site
478435001783	oxyanion hole (OAH) forming residues; other site
478435001784	trimer interface [polypeptide binding]; other site
478435001785	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
478435001786	PaaX-like protein; Region: PaaX; pfam07848
478435001787	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
478435001788	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435001789	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435001790	substrate binding site [chemical binding]; other site
478435001791	oxyanion hole (OAH) forming residues; other site
478435001792	trimer interface [polypeptide binding]; other site
478435001793	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435001794	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
478435001795	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
478435001796	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
478435001797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435001798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435001799	WHG domain; Region: WHG; pfam13305
478435001800	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
478435001801	S17 interaction site [polypeptide binding]; other site
478435001802	S8 interaction site; other site
478435001803	16S rRNA interaction site [nucleotide binding]; other site
478435001804	streptomycin interaction site [chemical binding]; other site
478435001805	23S rRNA interaction site [nucleotide binding]; other site
478435001806	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
478435001807	30S ribosomal protein S7; Validated; Region: PRK05302
478435001808	elongation factor G; Reviewed; Region: PRK00007
478435001809	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
478435001810	G1 box; other site
478435001811	putative GEF interaction site [polypeptide binding]; other site
478435001812	GTP/Mg2+ binding site [chemical binding]; other site
478435001813	Switch I region; other site
478435001814	G2 box; other site
478435001815	G3 box; other site
478435001816	Switch II region; other site
478435001817	G4 box; other site
478435001818	G5 box; other site
478435001819	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
478435001820	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
478435001821	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
478435001822	elongation factor Tu; Reviewed; Region: PRK00049
478435001823	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
478435001824	G1 box; other site
478435001825	GEF interaction site [polypeptide binding]; other site
478435001826	GTP/Mg2+ binding site [chemical binding]; other site
478435001827	Switch I region; other site
478435001828	G2 box; other site
478435001829	G3 box; other site
478435001830	Switch II region; other site
478435001831	G4 box; other site
478435001832	G5 box; other site
478435001833	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
478435001834	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
478435001835	Antibiotic Binding Site [chemical binding]; other site
478435001836	Short C-terminal domain; Region: SHOCT; pfam09851
478435001837	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
478435001838	classical (c) SDRs; Region: SDR_c; cd05233
478435001839	NAD(P) binding site [chemical binding]; other site
478435001840	active site
478435001841	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
478435001842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435001843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
478435001844	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
478435001845	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435001846	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
478435001847	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
478435001848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435001849	FeS/SAM binding site; other site
478435001850	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
478435001851	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
478435001852	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435001853	phosphate binding site [ion binding]; other site
478435001854	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
478435001855	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
478435001856	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
478435001857	Probable Catalytic site; other site
478435001858	metal-binding site
478435001859	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
478435001860	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
478435001861	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
478435001862	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
478435001863	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
478435001864	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
478435001865	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
478435001866	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
478435001867	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
478435001868	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
478435001869	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
478435001870	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
478435001871	putative translocon binding site; other site
478435001872	protein-rRNA interface [nucleotide binding]; other site
478435001873	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
478435001874	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
478435001875	G-X-X-G motif; other site
478435001876	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
478435001877	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
478435001878	23S rRNA interface [nucleotide binding]; other site
478435001879	5S rRNA interface [nucleotide binding]; other site
478435001880	putative antibiotic binding site [chemical binding]; other site
478435001881	L25 interface [polypeptide binding]; other site
478435001882	L27 interface [polypeptide binding]; other site
478435001883	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
478435001884	putative translocon interaction site; other site
478435001885	23S rRNA interface [nucleotide binding]; other site
478435001886	signal recognition particle (SRP54) interaction site; other site
478435001887	L23 interface [polypeptide binding]; other site
478435001888	trigger factor interaction site; other site
478435001889	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
478435001890	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
478435001891	Sulfatase; Region: Sulfatase; pfam00884
478435001892	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
478435001893	Uncharacterized conserved protein [Function unknown]; Region: COG1262
478435001894	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
478435001895	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
478435001896	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
478435001897	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
478435001898	RNA binding site [nucleotide binding]; other site
478435001899	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
478435001900	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
478435001901	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
478435001902	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
478435001903	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
478435001904	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
478435001905	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
478435001906	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
478435001907	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
478435001908	5S rRNA interface [nucleotide binding]; other site
478435001909	23S rRNA interface [nucleotide binding]; other site
478435001910	L5 interface [polypeptide binding]; other site
478435001911	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
478435001912	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
478435001913	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
478435001914	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
478435001915	23S rRNA binding site [nucleotide binding]; other site
478435001916	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
478435001917	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
478435001918	tandem repeat interface [polypeptide binding]; other site
478435001919	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
478435001920	oligomer interface [polypeptide binding]; other site
478435001921	active site residues [active]
478435001922	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
478435001923	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
478435001924	tandem repeat interface [polypeptide binding]; other site
478435001925	oligomer interface [polypeptide binding]; other site
478435001926	active site residues [active]
478435001927	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435001928	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435001929	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435001930	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435001931	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
478435001932	intersubunit interface [polypeptide binding]; other site
478435001933	active site
478435001934	Zn2+ binding site [ion binding]; other site
478435001935	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
478435001936	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
478435001937	NAD binding site [chemical binding]; other site
478435001938	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
478435001939	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435001940	nucleotide binding site [chemical binding]; other site
478435001941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
478435001942	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435001943	Coenzyme A binding pocket [chemical binding]; other site
478435001944	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435001945	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435001946	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
478435001947	SecY translocase; Region: SecY; pfam00344
478435001948	adenylate kinase; Reviewed; Region: adk; PRK00279
478435001949	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
478435001950	AMP-binding site [chemical binding]; other site
478435001951	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
478435001952	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
478435001953	active site
478435001954	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
478435001955	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435001956	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435001957	DNA binding residues [nucleotide binding]
478435001958	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
478435001959	Putative zinc-finger; Region: zf-HC2; pfam13490
478435001960	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435001961	MarR family; Region: MarR; pfam01047
478435001962	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435001963	TIGR03086 family protein; Region: TIGR03086
478435001964	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
478435001965	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
478435001966	Transposase; Region: DDE_Tnp_ISL3; pfam01610
478435001967	Helix-turn-helix domain; Region: HTH_17; pfam12728
478435001968	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
478435001969	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435001970	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435001971	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
478435001972	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
478435001973	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435001974	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435001975	active site
478435001976	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
478435001977	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
478435001978	tetrameric interface [polypeptide binding]; other site
478435001979	NAD binding site [chemical binding]; other site
478435001980	catalytic residues [active]
478435001981	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435001982	catalytic core [active]
478435001983	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435001984	PPE family; Region: PPE; pfam00823
478435001985	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435001986	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435001987	Helix-turn-helix domain; Region: HTH_28; pfam13518
478435001988	Winged helix-turn helix; Region: HTH_29; pfam13551
478435001989	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435001990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435001991	active site
478435001992	phosphorylation site [posttranslational modification]
478435001993	intermolecular recognition site; other site
478435001994	dimerization interface [polypeptide binding]; other site
478435001995	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435001996	DNA binding site [nucleotide binding]
478435001997	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435001998	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435001999	dimerization interface [polypeptide binding]; other site
478435002000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435002001	dimer interface [polypeptide binding]; other site
478435002002	phosphorylation site [posttranslational modification]
478435002003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435002004	ATP binding site [chemical binding]; other site
478435002005	Mg2+ binding site [ion binding]; other site
478435002006	G-X-G motif; other site
478435002007	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
478435002008	nucleotide binding site/active site [active]
478435002009	HIT family signature motif; other site
478435002010	catalytic residue [active]
478435002011	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
478435002012	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
478435002013	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
478435002014	NAD binding site [chemical binding]; other site
478435002015	catalytic Zn binding site [ion binding]; other site
478435002016	substrate binding site [chemical binding]; other site
478435002017	structural Zn binding site [ion binding]; other site
478435002018	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
478435002019	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
478435002020	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
478435002021	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435002022	Cytochrome P450; Region: p450; cl12078
478435002023	short chain dehydrogenase; Provisional; Region: PRK07775
478435002024	classical (c) SDRs; Region: SDR_c; cd05233
478435002025	NAD(P) binding site [chemical binding]; other site
478435002026	active site
478435002027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435002028	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
478435002029	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
478435002030	NAD binding site [chemical binding]; other site
478435002031	catalytic residues [active]
478435002032	short chain dehydrogenase; Provisional; Region: PRK07774
478435002033	classical (c) SDRs; Region: SDR_c; cd05233
478435002034	NAD(P) binding site [chemical binding]; other site
478435002035	active site
478435002036	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
478435002037	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
478435002038	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
478435002039	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
478435002040	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
478435002041	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
478435002042	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
478435002043	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
478435002044	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
478435002045	Predicted esterase [General function prediction only]; Region: COG0627
478435002046	S-formylglutathione hydrolase; Region: PLN02442
478435002047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
478435002048	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
478435002049	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
478435002050	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
478435002051	tetramer interface [polypeptide binding]; other site
478435002052	active site
478435002053	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435002054	Cytochrome P450; Region: p450; cl12078
478435002055	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
478435002056	ATP binding site [chemical binding]; other site
478435002057	active site
478435002058	substrate binding site [chemical binding]; other site
478435002059	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
478435002060	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435002061	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435002062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435002063	putative substrate translocation pore; other site
478435002064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435002065	Predicted deacetylase [General function prediction only]; Region: COG3233
478435002066	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
478435002067	putative active site [active]
478435002068	putative Zn binding site [ion binding]; other site
478435002069	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
478435002070	FAD binding domain; Region: FAD_binding_2; pfam00890
478435002071	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
478435002072	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
478435002073	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
478435002074	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
478435002075	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
478435002076	putative active site [active]
478435002077	catalytic triad [active]
478435002078	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
478435002079	Transglutaminase/protease-like homologues; Region: TGc; smart00460
478435002080	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435002081	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
478435002082	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
478435002083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435002084	DNA-binding site [nucleotide binding]; DNA binding site
478435002085	UTRA domain; Region: UTRA; pfam07702
478435002086	Uncharacterized conserved protein [Function unknown]; Region: COG1359
478435002087	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
478435002088	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
478435002089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435002090	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
478435002091	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435002092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
478435002093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435002094	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
478435002095	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
478435002096	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
478435002097	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
478435002098	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
478435002099	active site
478435002100	metal binding site [ion binding]; metal-binding site
478435002101	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
478435002102	active site
478435002103	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435002104	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
478435002105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
478435002106	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
478435002107	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
478435002108	dimerization interface [polypeptide binding]; other site
478435002109	ATP binding site [chemical binding]; other site
478435002110	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
478435002111	dimerization interface [polypeptide binding]; other site
478435002112	ATP binding site [chemical binding]; other site
478435002113	CAAX protease self-immunity; Region: Abi; pfam02517
478435002114	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
478435002115	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
478435002116	active site
478435002117	metal binding site [ion binding]; metal-binding site
478435002118	hexamer interface [polypeptide binding]; other site
478435002119	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
478435002120	amidophosphoribosyltransferase; Provisional; Region: PRK07847
478435002121	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
478435002122	active site
478435002123	tetramer interface [polypeptide binding]; other site
478435002124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435002125	active site
478435002126	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
478435002127	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
478435002128	dimerization interface [polypeptide binding]; other site
478435002129	putative ATP binding site [chemical binding]; other site
478435002130	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
478435002131	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
478435002132	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
478435002133	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
478435002134	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
478435002135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435002136	catalytic residue [active]
478435002137	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
478435002138	heme-binding site [chemical binding]; other site
478435002139	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
478435002140	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
478435002141	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
478435002142	active site residue [active]
478435002143	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
478435002144	active site residue [active]
478435002145	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
478435002146	catalytic residues [active]
478435002147	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
478435002148	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435002149	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435002150	DNA binding site [nucleotide binding]
478435002151	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
478435002152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435002153	Coenzyme A binding pocket [chemical binding]; other site
478435002154	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
478435002155	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
478435002156	Walker A/P-loop; other site
478435002157	ATP binding site [chemical binding]; other site
478435002158	Q-loop/lid; other site
478435002159	ABC transporter signature motif; other site
478435002160	Walker B; other site
478435002161	D-loop; other site
478435002162	H-loop/switch region; other site
478435002163	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
478435002164	PhoU domain; Region: PhoU; pfam01895
478435002165	PhoU domain; Region: PhoU; pfam01895
478435002166	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
478435002167	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
478435002168	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
478435002169	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
478435002170	FMN binding site [chemical binding]; other site
478435002171	active site
478435002172	catalytic residues [active]
478435002173	substrate binding site [chemical binding]; other site
478435002174	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
478435002175	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
478435002176	homodimer interface [polypeptide binding]; other site
478435002177	putative substrate binding pocket [chemical binding]; other site
478435002178	diiron center [ion binding]; other site
478435002179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
478435002180	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435002181	dimerization interface [polypeptide binding]; other site
478435002182	putative DNA binding site [nucleotide binding]; other site
478435002183	putative Zn2+ binding site [ion binding]; other site
478435002184	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
478435002185	dimer interface [polypeptide binding]; other site
478435002186	catalytic motif [active]
478435002187	nucleoside/Zn binding site; other site
478435002188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435002189	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435002190	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435002191	TIGR04255 family protein; Region: sporadTIGR04255
478435002192	PE family; Region: PE; pfam00934
478435002193	PE family; Region: PE; pfam00934
478435002194	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435002195	putative transposase OrfB; Reviewed; Region: PHA02517
478435002196	HTH-like domain; Region: HTH_21; pfam13276
478435002197	Integrase core domain; Region: rve; pfam00665
478435002198	Integrase core domain; Region: rve_3; pfam13683
478435002199	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435002200	Transposase; Region: HTH_Tnp_1; cl17663
478435002201	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
478435002202	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
478435002203	MoaE interaction surface [polypeptide binding]; other site
478435002204	MoeB interaction surface [polypeptide binding]; other site
478435002205	thiocarboxylated glycine; other site
478435002206	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
478435002207	trimer interface [polypeptide binding]; other site
478435002208	dimer interface [polypeptide binding]; other site
478435002209	putative active site [active]
478435002210	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
478435002211	aromatic arch; other site
478435002212	DCoH dimer interaction site [polypeptide binding]; other site
478435002213	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
478435002214	DCoH tetramer interaction site [polypeptide binding]; other site
478435002215	substrate binding site [chemical binding]; other site
478435002216	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
478435002217	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435002218	FeS/SAM binding site; other site
478435002219	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
478435002220	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435002221	FAD binding domain; Region: FAD_binding_4; pfam01565
478435002222	ferredoxin-NADP+ reductase; Region: PLN02852
478435002223	peptide chain release factor 2; Validated; Region: prfB; PRK00578
478435002224	This domain is found in peptide chain release factors; Region: PCRF; smart00937
478435002225	RF-1 domain; Region: RF-1; pfam00472
478435002226	Mechanosensitive ion channel; Region: MS_channel; pfam00924
478435002227	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
478435002228	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
478435002229	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435002230	Walker A/P-loop; other site
478435002231	ATP binding site [chemical binding]; other site
478435002232	Q-loop/lid; other site
478435002233	ABC transporter signature motif; other site
478435002234	Walker B; other site
478435002235	D-loop; other site
478435002236	H-loop/switch region; other site
478435002237	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
478435002238	FtsX-like permease family; Region: FtsX; pfam02687
478435002239	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
478435002240	SmpB-tmRNA interface; other site
478435002241	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435002242	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
478435002243	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
478435002244	PemK-like protein; Region: PemK; pfam02452
478435002245	PE family; Region: PE; pfam00934
478435002246	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435002247	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
478435002248	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
478435002249	Predicted transcriptional regulators [Transcription]; Region: COG1733
478435002250	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435002251	dimerization interface [polypeptide binding]; other site
478435002252	putative DNA binding site [nucleotide binding]; other site
478435002253	putative Zn2+ binding site [ion binding]; other site
478435002254	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435002255	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435002256	active site
478435002257	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
478435002258	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435002259	Protein of unknown function (DUF808); Region: DUF808; cl01002
478435002260	Patatin-like phospholipase; Region: Patatin; pfam01734
478435002261	SPFH domain / Band 7 family; Region: Band_7; pfam01145
478435002262	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
478435002263	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
478435002264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435002265	acyl-activating enzyme (AAE) consensus motif; other site
478435002266	AMP binding site [chemical binding]; other site
478435002267	active site
478435002268	CoA binding site [chemical binding]; other site
478435002269	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435002270	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435002271	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
478435002272	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435002273	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435002274	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
478435002275	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
478435002276	NAD binding site [chemical binding]; other site
478435002277	catalytic Zn binding site [ion binding]; other site
478435002278	substrate binding site [chemical binding]; other site
478435002279	structural Zn binding site [ion binding]; other site
478435002280	short chain dehydrogenase; Provisional; Region: PRK07832
478435002281	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435002282	NAD(P) binding site [chemical binding]; other site
478435002283	active site
478435002284	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
478435002285	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435002286	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435002287	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
478435002288	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
478435002289	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
478435002290	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970
478435002291	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435002292	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435002293	active site
478435002294	ATP binding site [chemical binding]; other site
478435002295	substrate binding site [chemical binding]; other site
478435002296	activation loop (A-loop); other site
478435002297	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
478435002298	AAA ATPase domain; Region: AAA_16; pfam13191
478435002299	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
478435002300	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435002301	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
478435002302	Sulfatase; Region: Sulfatase; pfam00884
478435002303	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
478435002304	putative hydrophobic ligand binding site [chemical binding]; other site
478435002305	protein interface [polypeptide binding]; other site
478435002306	gate; other site
478435002307	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
478435002308	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435002309	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435002310	active site
478435002311	Uncharacterized conserved protein [Function unknown]; Region: COG3189
478435002312	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435002313	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
478435002314	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
478435002315	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
478435002316	camphor resistance protein CrcB; Provisional; Region: PRK14228
478435002317	camphor resistance protein CrcB; Provisional; Region: PRK14216
478435002318	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
478435002319	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
478435002320	active site
478435002321	substrate binding site [chemical binding]; other site
478435002322	metal binding site [ion binding]; metal-binding site
478435002323	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435002324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
478435002325	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435002326	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
478435002327	Predicted membrane protein [Function unknown]; Region: COG2259
478435002328	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
478435002329	Carbon starvation protein CstA; Region: CstA; pfam02554
478435002330	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
478435002331	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
478435002332	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
478435002333	active site
478435002334	DNA binding site [nucleotide binding]
478435002335	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
478435002336	DNA binding site [nucleotide binding]
478435002337	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435002338	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
478435002339	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435002340	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435002341	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435002342	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435002343	active site
478435002344	Transcriptional regulators [Transcription]; Region: FadR; COG2186
478435002345	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435002346	DNA-binding site [nucleotide binding]; DNA binding site
478435002347	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
478435002348	Transcriptional regulators [Transcription]; Region: FadR; COG2186
478435002349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435002350	DNA-binding site [nucleotide binding]; DNA binding site
478435002351	FCD domain; Region: FCD; pfam07729
478435002352	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435002353	Cytochrome P450; Region: p450; cl12078
478435002354	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435002355	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435002356	short chain dehydrogenase; Provisional; Region: PRK07832
478435002357	classical (c) SDRs; Region: SDR_c; cd05233
478435002358	NAD(P) binding site [chemical binding]; other site
478435002359	active site
478435002360	DNA polymerase IV; Validated; Region: PRK03352
478435002361	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
478435002362	active site
478435002363	DNA binding site [nucleotide binding]
478435002364	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
478435002365	Predicted flavoprotein [General function prediction only]; Region: COG0431
478435002366	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
478435002367	catalytic residues [active]
478435002368	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
478435002369	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
478435002370	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
478435002371	Class I ribonucleotide reductase; Region: RNR_I; cd01679
478435002372	active site
478435002373	dimer interface [polypeptide binding]; other site
478435002374	catalytic residues [active]
478435002375	effector binding site; other site
478435002376	R2 peptide binding site; other site
478435002377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435002378	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435002379	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435002380	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435002381	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
478435002382	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
478435002383	dimer interface [polypeptide binding]; other site
478435002384	putative radical transfer pathway; other site
478435002385	diiron center [ion binding]; other site
478435002386	tyrosyl radical; other site
478435002387	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
478435002388	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
478435002389	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
478435002390	putative NAD(P) binding site [chemical binding]; other site
478435002391	putative substrate binding site [chemical binding]; other site
478435002392	catalytic Zn binding site [ion binding]; other site
478435002393	structural Zn binding site [ion binding]; other site
478435002394	dimer interface [polypeptide binding]; other site
478435002395	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
478435002396	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
478435002397	siderophore binding site; other site
478435002398	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
478435002399	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
478435002400	D-pathway; other site
478435002401	Putative ubiquinol binding site [chemical binding]; other site
478435002402	Low-spin heme (heme b) binding site [chemical binding]; other site
478435002403	Putative water exit pathway; other site
478435002404	Binuclear center (heme o3/CuB) [ion binding]; other site
478435002405	K-pathway; other site
478435002406	Putative proton exit pathway; other site
478435002407	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
478435002408	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
478435002409	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
478435002410	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435002411	motif II; other site
478435002412	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
478435002413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435002414	Walker A/P-loop; other site
478435002415	ATP binding site [chemical binding]; other site
478435002416	Q-loop/lid; other site
478435002417	ABC transporter signature motif; other site
478435002418	Walker B; other site
478435002419	D-loop; other site
478435002420	H-loop/switch region; other site
478435002421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435002422	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435002423	substrate binding site [chemical binding]; other site
478435002424	oxyanion hole (OAH) forming residues; other site
478435002425	trimer interface [polypeptide binding]; other site
478435002426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002427	S-adenosylmethionine binding site [chemical binding]; other site
478435002428	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
478435002429	FOG: WD40-like repeat [Function unknown]; Region: COG1520
478435002430	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
478435002431	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
478435002432	trimer interface [polypeptide binding]; other site
478435002433	active site
478435002434	substrate binding site [chemical binding]; other site
478435002435	CoA binding site [chemical binding]; other site
478435002436	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
478435002437	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
478435002438	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
478435002439	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
478435002440	Uncharacterized conserved protein [Function unknown]; Region: COG1543
478435002441	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
478435002442	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
478435002443	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002444	S-adenosylmethionine binding site [chemical binding]; other site
478435002445	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
478435002446	Ligand binding site [chemical binding]; other site
478435002447	Electron transfer flavoprotein domain; Region: ETF; pfam01012
478435002448	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
478435002449	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
478435002450	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
478435002451	Putative hemolysin [General function prediction only]; Region: COG3176
478435002452	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435002453	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435002454	putative acyl-acceptor binding pocket; other site
478435002455	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
478435002456	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
478435002457	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435002458	catalytic residue [active]
478435002459	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
478435002460	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
478435002461	Ligand Binding Site [chemical binding]; other site
478435002462	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435002463	MULE transposase domain; Region: MULE; pfam10551
478435002464	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435002465	PPE family; Region: PPE; pfam00823
478435002466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435002467	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435002468	PPE family; Region: PPE; pfam00823
478435002469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435002470	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435002471	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
478435002472	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
478435002473	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
478435002474	nucleotide binding pocket [chemical binding]; other site
478435002475	K-X-D-G motif; other site
478435002476	catalytic site [active]
478435002477	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
478435002478	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
478435002479	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
478435002480	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
478435002481	Dimer interface [polypeptide binding]; other site
478435002482	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
478435002483	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
478435002484	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
478435002485	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
478435002486	6-phosphofructokinase; Provisional; Region: PRK03202
478435002487	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
478435002488	active site
478435002489	ADP/pyrophosphate binding site [chemical binding]; other site
478435002490	dimerization interface [polypeptide binding]; other site
478435002491	allosteric effector site; other site
478435002492	fructose-1,6-bisphosphate binding site; other site
478435002493	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
478435002494	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
478435002495	GatB domain; Region: GatB_Yqey; smart00845
478435002496	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
478435002497	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
478435002498	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
478435002499	Predicted membrane protein [Function unknown]; Region: COG2259
478435002500	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
478435002501	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
478435002502	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
478435002503	PYR/PP interface [polypeptide binding]; other site
478435002504	dimer interface [polypeptide binding]; other site
478435002505	TPP binding site [chemical binding]; other site
478435002506	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
478435002507	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
478435002508	TPP-binding site [chemical binding]; other site
478435002509	dimer interface [polypeptide binding]; other site
478435002510	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
478435002511	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
478435002512	putative valine binding site [chemical binding]; other site
478435002513	dimer interface [polypeptide binding]; other site
478435002514	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
478435002515	ketol-acid reductoisomerase; Provisional; Region: PRK05479
478435002516	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
478435002517	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
478435002518	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
478435002519	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
478435002520	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
478435002521	Protein of unknown function (DUF433); Region: DUF433; pfam04255
478435002522	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
478435002523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435002524	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
478435002525	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
478435002526	ligand binding site [chemical binding]; other site
478435002527	NAD binding site [chemical binding]; other site
478435002528	dimerization interface [polypeptide binding]; other site
478435002529	catalytic site [active]
478435002530	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
478435002531	putative L-serine binding site [chemical binding]; other site
478435002532	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
478435002533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435002534	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435002535	putative substrate translocation pore; other site
478435002536	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
478435002537	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
478435002538	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
478435002539	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
478435002540	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435002541	active site
478435002542	HIGH motif; other site
478435002543	nucleotide binding site [chemical binding]; other site
478435002544	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
478435002545	active site
478435002546	KMSKS motif; other site
478435002547	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
478435002548	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
478435002549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002550	S-adenosylmethionine binding site [chemical binding]; other site
478435002551	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
478435002552	Transcriptional regulator [Transcription]; Region: IclR; COG1414
478435002553	Bacterial transcriptional regulator; Region: IclR; pfam01614
478435002554	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
478435002555	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
478435002556	substrate binding site [chemical binding]; other site
478435002557	ligand binding site [chemical binding]; other site
478435002558	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
478435002559	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
478435002560	substrate binding site [chemical binding]; other site
478435002561	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
478435002562	IHF - DNA interface [nucleotide binding]; other site
478435002563	IHF dimer interface [polypeptide binding]; other site
478435002564	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
478435002565	active site
478435002566	Ap6A binding site [chemical binding]; other site
478435002567	nudix motif; other site
478435002568	metal binding site [ion binding]; metal-binding site
478435002569	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435002570	catalytic core [active]
478435002571	polyphosphate kinase; Provisional; Region: PRK05443
478435002572	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
478435002573	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
478435002574	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
478435002575	putative domain interface [polypeptide binding]; other site
478435002576	putative active site [active]
478435002577	catalytic site [active]
478435002578	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
478435002579	putative domain interface [polypeptide binding]; other site
478435002580	putative active site [active]
478435002581	catalytic site [active]
478435002582	Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920
478435002583	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
478435002584	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
478435002585	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
478435002586	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
478435002587	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
478435002588	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
478435002589	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
478435002590	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435002591	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
478435002592	catalytic residues [active]
478435002593	catalytic nucleophile [active]
478435002594	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
478435002595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435002596	Probable transposase; Region: OrfB_IS605; pfam01385
478435002597	thiamine monophosphate kinase; Provisional; Region: PRK05731
478435002598	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
478435002599	ATP binding site [chemical binding]; other site
478435002600	dimerization interface [polypeptide binding]; other site
478435002601	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
478435002602	ligand binding site [chemical binding]; other site
478435002603	active site
478435002604	UGI interface [polypeptide binding]; other site
478435002605	catalytic site [active]
478435002606	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
478435002607	potential frameshift: common BLAST hit: gi|385995856|ref|YP_005914154.1| DAK2 domain-containing protein
478435002608	DAK2 domain; Region: Dak2; cl03685
478435002609	DAK2 domain; Region: Dak2; cl03685
478435002610	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
478435002611	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
478435002612	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
478435002613	generic binding surface II; other site
478435002614	ssDNA binding site; other site
478435002615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435002616	ATP binding site [chemical binding]; other site
478435002617	putative Mg++ binding site [ion binding]; other site
478435002618	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435002619	nucleotide binding region [chemical binding]; other site
478435002620	ATP-binding site [chemical binding]; other site
478435002621	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
478435002622	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
478435002623	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
478435002624	active site
478435002625	catalytic tetrad [active]
478435002626	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435002627	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435002628	substrate binding pocket [chemical binding]; other site
478435002629	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
478435002630	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
478435002631	catalytic residues [active]
478435002632	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
478435002633	putative active site [active]
478435002634	redox center [active]
478435002635	pyruvate carboxylase; Reviewed; Region: PRK12999
478435002636	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435002637	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435002638	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
478435002639	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
478435002640	active site
478435002641	catalytic residues [active]
478435002642	metal binding site [ion binding]; metal-binding site
478435002643	homodimer binding site [polypeptide binding]; other site
478435002644	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
478435002645	carboxyltransferase (CT) interaction site; other site
478435002646	biotinylation site [posttranslational modification]; other site
478435002647	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
478435002648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002649	S-adenosylmethionine binding site [chemical binding]; other site
478435002650	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
478435002651	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
478435002652	active site
478435002653	(T/H)XGH motif; other site
478435002654	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
478435002655	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
478435002656	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
478435002657	putative active site [active]
478435002658	putative substrate binding site [chemical binding]; other site
478435002659	putative cosubstrate binding site; other site
478435002660	catalytic site [active]
478435002661	Predicted permease; Region: DUF318; pfam03773
478435002662	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
478435002663	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
478435002664	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
478435002665	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
478435002666	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
478435002667	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
478435002668	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
478435002669	active site
478435002670	TDP-binding site; other site
478435002671	acceptor substrate-binding pocket; other site
478435002672	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
478435002673	metal-binding site
478435002674	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
478435002675	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
478435002676	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435002677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002678	S-adenosylmethionine binding site [chemical binding]; other site
478435002679	Uncharacterized conserved protein [Function unknown]; Region: COG3268
478435002680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435002681	S-adenosylmethionine binding site [chemical binding]; other site
478435002682	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
478435002683	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435002684	acyl-CoA synthetase; Validated; Region: PRK05850
478435002685	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435002686	acyl-activating enzyme (AAE) consensus motif; other site
478435002687	active site
478435002688	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
478435002689	acyl-CoA synthetase; Validated; Region: PRK06060
478435002690	Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919
478435002691	dimer interface [polypeptide binding]; other site
478435002692	acyl-activating enzyme (AAE) consensus motif; other site
478435002693	putative active site [active]
478435002694	putative AMP binding site [chemical binding]; other site
478435002695	putative CoA binding site [chemical binding]; other site
478435002696	chemical substrate binding site [chemical binding]; other site
478435002697	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002698	Erythronolide synthase docking; Region: Docking; pfam08990
478435002699	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002700	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002701	active site
478435002702	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435002703	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435002704	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435002705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435002706	Enoylreductase; Region: PKS_ER; smart00829
478435002707	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435002708	NAD(P) binding site [chemical binding]; other site
478435002709	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
478435002710	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435002711	putative NADP binding site [chemical binding]; other site
478435002712	active site
478435002713	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002714	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
478435002715	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
478435002716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435002717	ATP binding site [chemical binding]; other site
478435002718	Walker A motif; other site
478435002719	Walker B motif; other site
478435002720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
478435002721	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
478435002722	Integrase core domain; Region: rve; pfam00665
478435002723	MMPL family; Region: MMPL; pfam03176
478435002724	acyl-CoA synthetase; Validated; Region: PRK05850
478435002725	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435002726	acyl-activating enzyme (AAE) consensus motif; other site
478435002727	active site
478435002728	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002729	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002730	active site
478435002731	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
478435002732	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435002733	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435002734	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435002735	Enoylreductase; Region: PKS_ER; smart00829
478435002736	NAD(P) binding site [chemical binding]; other site
478435002737	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435002738	KR domain; Region: KR; pfam08659
478435002739	putative NADP binding site [chemical binding]; other site
478435002740	active site
478435002741	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002742	acyltransferase PapA5; Provisional; Region: PRK09294
478435002743	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
478435002744	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
478435002745	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
478435002746	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
478435002747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435002748	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
478435002749	Walker A/P-loop; other site
478435002750	ATP binding site [chemical binding]; other site
478435002751	Q-loop/lid; other site
478435002752	ABC transporter signature motif; other site
478435002753	Walker B; other site
478435002754	D-loop; other site
478435002755	H-loop/switch region; other site
478435002756	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002757	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002758	active site
478435002759	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435002760	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435002761	Condensation domain; Region: Condensation; pfam00668
478435002762	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
478435002763	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002764	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002765	active site
478435002766	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435002767	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435002768	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435002769	KR domain; Region: KR; pfam08659
478435002770	putative NADP binding site [chemical binding]; other site
478435002771	active site
478435002772	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002773	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002774	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002775	active site
478435002776	Acyl transferase domain; Region: Acyl_transf_1; cl08282
478435002777	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435002778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435002779	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435002780	Enoylreductase; Region: PKS_ER; smart00829
478435002781	NAD(P) binding site [chemical binding]; other site
478435002782	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435002783	KR domain; Region: KR; pfam08659
478435002784	putative NADP binding site [chemical binding]; other site
478435002785	active site
478435002786	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002787	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002788	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
478435002789	active site
478435002790	Acyl transferase domain; Region: Acyl_transf_1; cl08282
478435002791	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
478435002792	KR domain; Region: KR; pfam08659
478435002793	NADP binding site [chemical binding]; other site
478435002794	active site
478435002795	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002796	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435002797	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435002798	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435002799	active site
478435002800	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
478435002801	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435002802	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
478435002803	NADP binding site [chemical binding]; other site
478435002804	KR domain; Region: KR; pfam08659
478435002805	active site
478435002806	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435002807	acyl-CoA synthetase; Validated; Region: PRK05850
478435002808	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435002809	acyl-activating enzyme (AAE) consensus motif; other site
478435002810	active site
478435002811	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
478435002812	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
478435002813	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
478435002814	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
478435002815	ribonuclease III; Reviewed; Region: rnc; PRK00102
478435002816	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
478435002817	dimerization interface [polypeptide binding]; other site
478435002818	active site
478435002819	metal binding site [ion binding]; metal-binding site
478435002820	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
478435002821	dsRNA binding site [nucleotide binding]; other site
478435002822	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
478435002823	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
478435002824	DNA binding site [nucleotide binding]
478435002825	catalytic residue [active]
478435002826	H2TH interface [polypeptide binding]; other site
478435002827	putative catalytic residues [active]
478435002828	turnover-facilitating residue; other site
478435002829	intercalation triad [nucleotide binding]; other site
478435002830	8OG recognition residue [nucleotide binding]; other site
478435002831	putative reading head residues; other site
478435002832	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
478435002833	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
478435002834	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
478435002835	acylphosphatase; Provisional; Region: PRK14422
478435002836	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
478435002837	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
478435002838	Walker A/P-loop; other site
478435002839	ATP binding site [chemical binding]; other site
478435002840	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
478435002841	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
478435002842	ABC transporter signature motif; other site
478435002843	Walker B; other site
478435002844	D-loop; other site
478435002845	H-loop/switch region; other site
478435002846	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
478435002847	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
478435002848	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
478435002849	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
478435002850	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
478435002851	Nitrogen regulatory protein P-II; Region: P-II; smart00938
478435002852	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
478435002853	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
478435002854	ATP binding site [chemical binding]; other site
478435002855	putative Mg++ binding site [ion binding]; other site
478435002856	signal recognition particle protein; Provisional; Region: PRK10867
478435002857	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
478435002858	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
478435002859	P loop; other site
478435002860	GTP binding site [chemical binding]; other site
478435002861	Signal peptide binding domain; Region: SRP_SPB; pfam02978
478435002862	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
478435002863	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
478435002864	active site
478435002865	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435002866	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435002867	active site
478435002868	ATP binding site [chemical binding]; other site
478435002869	substrate binding site [chemical binding]; other site
478435002870	activation loop (A-loop); other site
478435002871	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
478435002872	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
478435002873	active site
478435002874	putative substrate binding pocket [chemical binding]; other site
478435002875	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
478435002876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435002877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435002878	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
478435002879	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
478435002880	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
478435002881	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
478435002882	hypothetical protein; Provisional; Region: PRK02821
478435002883	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
478435002884	G-X-X-G motif; other site
478435002885	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
478435002886	RimM N-terminal domain; Region: RimM; pfam01782
478435002887	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
478435002888	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
478435002889	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
478435002890	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
478435002891	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
478435002892	Catalytic site [active]
478435002893	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
478435002894	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
478435002895	RNA/DNA hybrid binding site [nucleotide binding]; other site
478435002896	active site
478435002897	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
478435002898	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
478435002899	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
478435002900	putative molybdopterin cofactor binding site [chemical binding]; other site
478435002901	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
478435002902	putative molybdopterin cofactor binding site; other site
478435002903	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
478435002904	hypothetical protein; Reviewed; Region: PRK12497
478435002905	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
478435002906	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
478435002907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435002908	Walker A motif; other site
478435002909	ATP binding site [chemical binding]; other site
478435002910	Walker B motif; other site
478435002911	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
478435002912	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
478435002913	DNA protecting protein DprA; Region: dprA; TIGR00732
478435002914	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
478435002915	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
478435002916	FAD binding pocket [chemical binding]; other site
478435002917	FAD binding motif [chemical binding]; other site
478435002918	phosphate binding motif [ion binding]; other site
478435002919	NAD binding pocket [chemical binding]; other site
478435002920	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
478435002921	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435002922	active site
478435002923	DNA binding site [nucleotide binding]
478435002924	Int/Topo IB signature motif; other site
478435002925	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
478435002926	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435002927	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435002928	PPE family; Region: PPE; pfam00823
478435002929	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435002930	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
478435002931	Peptidase family M23; Region: Peptidase_M23; pfam01551
478435002932	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
478435002933	rRNA interaction site [nucleotide binding]; other site
478435002934	S8 interaction site; other site
478435002935	putative laminin-1 binding site; other site
478435002936	elongation factor Ts; Provisional; Region: tsf; PRK09377
478435002937	UBA/TS-N domain; Region: UBA; pfam00627
478435002938	Elongation factor TS; Region: EF_TS; pfam00889
478435002939	Elongation factor TS; Region: EF_TS; pfam00889
478435002940	amidase; Provisional; Region: PRK07869
478435002941	Amidase; Region: Amidase; pfam01425
478435002942	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435002943	MarR family; Region: MarR; pfam01047
478435002944	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435002945	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
478435002946	catalytic residues [active]
478435002947	catalytic nucleophile [active]
478435002948	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
478435002949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435002950	Probable transposase; Region: OrfB_IS605; pfam01385
478435002951	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435002952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435002953	DNA binding site [nucleotide binding]
478435002954	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
478435002955	putative nucleotide binding site [chemical binding]; other site
478435002956	uridine monophosphate binding site [chemical binding]; other site
478435002957	homohexameric interface [polypeptide binding]; other site
478435002958	ribosome recycling factor; Reviewed; Region: frr; PRK00083
478435002959	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
478435002960	hinge region; other site
478435002961	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
478435002962	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
478435002963	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
478435002964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435002965	FeS/SAM binding site; other site
478435002966	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
478435002967	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435002968	catalytic residues [active]
478435002969	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
478435002970	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
478435002971	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
478435002972	Fasciclin domain; Region: Fasciclin; pfam02469
478435002973	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
478435002974	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
478435002975	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
478435002976	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435002977	catalytic residues [active]
478435002978	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
478435002979	Fasciclin domain; Region: Fasciclin; pfam02469
478435002980	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435002981	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435002982	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
478435002983	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
478435002984	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
478435002985	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
478435002986	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
478435002987	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
478435002988	active site
478435002989	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
478435002990	protein binding site [polypeptide binding]; other site
478435002991	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
478435002992	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
478435002993	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
478435002994	Predicted acetyltransferase [General function prediction only]; Region: COG3393
478435002995	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
478435002996	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
478435002997	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
478435002998	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
478435002999	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
478435003000	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
478435003001	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435003002	putative active site [active]
478435003003	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
478435003004	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
478435003005	active site
478435003006	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
478435003007	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
478435003008	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
478435003009	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
478435003010	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
478435003011	catalytic triad [active]
478435003012	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
478435003013	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
478435003014	NAD(P) binding site [chemical binding]; other site
478435003015	catalytic residues [active]
478435003016	short chain dehydrogenase; Provisional; Region: PRK06057
478435003017	classical (c) SDRs; Region: SDR_c; cd05233
478435003018	NAD(P) binding site [chemical binding]; other site
478435003019	active site
478435003020	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
478435003021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
478435003022	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
478435003023	mycothione reductase; Reviewed; Region: PRK07846
478435003024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435003025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435003026	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
478435003027	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
478435003028	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435003029	PE family; Region: PE; pfam00934
478435003030	malate:quinone oxidoreductase; Validated; Region: PRK05257
478435003031	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
478435003032	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
478435003033	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
478435003034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435003035	Walker A motif; other site
478435003036	ATP binding site [chemical binding]; other site
478435003037	Walker B motif; other site
478435003038	arginine finger; other site
478435003039	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
478435003040	metal ion-dependent adhesion site (MIDAS); other site
478435003041	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
478435003042	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
478435003043	homodimer interface [polypeptide binding]; other site
478435003044	Walker A motif; other site
478435003045	ATP binding site [chemical binding]; other site
478435003046	hydroxycobalamin binding site [chemical binding]; other site
478435003047	Walker B motif; other site
478435003048	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
478435003049	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
478435003050	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
478435003051	catalytic triad [active]
478435003052	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
478435003053	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
478435003054	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
478435003055	homodimer interface [polypeptide binding]; other site
478435003056	active site
478435003057	SAM binding site [chemical binding]; other site
478435003058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435003059	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435003060	putative substrate translocation pore; other site
478435003061	prolyl-tRNA synthetase; Provisional; Region: PRK09194
478435003062	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
478435003063	dimer interface [polypeptide binding]; other site
478435003064	motif 1; other site
478435003065	active site
478435003066	motif 2; other site
478435003067	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
478435003068	putative deacylase active site [active]
478435003069	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
478435003070	active site
478435003071	motif 3; other site
478435003072	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
478435003073	anticodon binding site; other site
478435003074	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
478435003075	dinuclear metal binding motif [ion binding]; other site
478435003076	ribosome maturation protein RimP; Reviewed; Region: PRK00092
478435003077	Sm and related proteins; Region: Sm_like; cl00259
478435003078	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
478435003079	putative oligomer interface [polypeptide binding]; other site
478435003080	putative RNA binding site [nucleotide binding]; other site
478435003081	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
478435003082	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
478435003083	NusA N-terminal domain; Region: NusA_N; pfam08529
478435003084	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
478435003085	RNA binding site [nucleotide binding]; other site
478435003086	homodimer interface [polypeptide binding]; other site
478435003087	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
478435003088	G-X-X-G motif; other site
478435003089	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
478435003090	G-X-X-G motif; other site
478435003091	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
478435003092	putative RNA binding cleft [nucleotide binding]; other site
478435003093	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
478435003094	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
478435003095	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
478435003096	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
478435003097	G1 box; other site
478435003098	putative GEF interaction site [polypeptide binding]; other site
478435003099	GTP/Mg2+ binding site [chemical binding]; other site
478435003100	Switch I region; other site
478435003101	G2 box; other site
478435003102	G3 box; other site
478435003103	Switch II region; other site
478435003104	G4 box; other site
478435003105	G5 box; other site
478435003106	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
478435003107	Translation-initiation factor 2; Region: IF-2; pfam11987
478435003108	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
478435003109	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
478435003110	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
478435003111	DHH family; Region: DHH; pfam01368
478435003112	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
478435003113	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
478435003114	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
478435003115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435003116	dimer interface [polypeptide binding]; other site
478435003117	conserved gate region; other site
478435003118	putative PBP binding loops; other site
478435003119	ABC-ATPase subunit interface; other site
478435003120	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
478435003121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435003122	dimer interface [polypeptide binding]; other site
478435003123	conserved gate region; other site
478435003124	putative PBP binding loops; other site
478435003125	ABC-ATPase subunit interface; other site
478435003126	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
478435003127	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
478435003128	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
478435003129	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
478435003130	Walker A/P-loop; other site
478435003131	ATP binding site [chemical binding]; other site
478435003132	Q-loop/lid; other site
478435003133	ABC transporter signature motif; other site
478435003134	Walker B; other site
478435003135	D-loop; other site
478435003136	H-loop/switch region; other site
478435003137	enoyl-CoA hydratase; Provisional; Region: PRK06190
478435003138	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435003139	substrate binding site [chemical binding]; other site
478435003140	oxyanion hole (OAH) forming residues; other site
478435003141	trimer interface [polypeptide binding]; other site
478435003142	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435003143	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
478435003144	putative active site [active]
478435003145	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
478435003146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
478435003147	Protein of unknown function (DUF2005); Region: DUF2005; pfam09407
478435003148	Uncharacterized conserved protein [Function unknown]; Region: COG2253
478435003149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
478435003150	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
478435003151	Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353
478435003152	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
478435003153	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
478435003154	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
478435003155	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663
478435003156	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662
478435003157	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699
478435003158	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636
478435003159	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
478435003160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435003161	Transposase; Region: HTH_Tnp_1; cl17663
478435003162	putative transposase OrfB; Reviewed; Region: PHA02517
478435003163	HTH-like domain; Region: HTH_21; pfam13276
478435003164	Integrase core domain; Region: rve; pfam00665
478435003165	Integrase core domain; Region: rve_3; pfam13683
478435003166	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
478435003167	Helix-turn-helix domain; Region: HTH_28; pfam13518
478435003168	Winged helix-turn helix; Region: HTH_29; pfam13551
478435003169	Integrase core domain; Region: rve; pfam00665
478435003170	Integrase core domain; Region: rve_3; pfam13683
478435003171	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
478435003172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
478435003173	Transposase; Region: DDE_Tnp_ISL3; pfam01610
478435003174	Integrase core domain; Region: rve; pfam00665
478435003175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
478435003176	Uncharacterized conserved protein [Function unknown]; Region: COG5586
478435003177	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
478435003178	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435003179	Predicted acyl esterases [General function prediction only]; Region: COG2936
478435003180	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
478435003181	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
478435003182	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
478435003183	Uncharacterized conserved protein [Function unknown]; Region: COG4717
478435003184	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
478435003185	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
478435003186	active site
478435003187	metal binding site [ion binding]; metal-binding site
478435003188	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
478435003189	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
478435003190	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
478435003191	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
478435003192	RNA binding site [nucleotide binding]; other site
478435003193	active site
478435003194	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
478435003195	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435003196	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
478435003197	catalytic residues [active]
478435003198	catalytic nucleophile [active]
478435003199	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
478435003200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435003201	Probable transposase; Region: OrfB_IS605; pfam01385
478435003202	lipid-transfer protein; Provisional; Region: PRK08256
478435003203	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435003204	active site
478435003205	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435003206	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435003207	active site
478435003208	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
478435003209	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435003210	putative DNA binding site [nucleotide binding]; other site
478435003211	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
478435003212	FeoA domain; Region: FeoA; pfam04023
478435003213	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
478435003214	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
478435003215	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
478435003216	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
478435003217	active site
478435003218	Riboflavin kinase; Region: Flavokinase; pfam01687
478435003219	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
478435003220	16S/18S rRNA binding site [nucleotide binding]; other site
478435003221	S13e-L30e interaction site [polypeptide binding]; other site
478435003222	25S rRNA binding site [nucleotide binding]; other site
478435003223	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
478435003224	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
478435003225	oligomer interface [polypeptide binding]; other site
478435003226	RNA binding site [nucleotide binding]; other site
478435003227	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
478435003228	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
478435003229	RNase E interface [polypeptide binding]; other site
478435003230	trimer interface [polypeptide binding]; other site
478435003231	active site
478435003232	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
478435003233	putative nucleic acid binding region [nucleotide binding]; other site
478435003234	G-X-X-G motif; other site
478435003235	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
478435003236	RNA binding site [nucleotide binding]; other site
478435003237	domain interface; other site
478435003238	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
478435003239	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
478435003240	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
478435003241	Nitronate monooxygenase; Region: NMO; pfam03060
478435003242	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
478435003243	FMN binding site [chemical binding]; other site
478435003244	substrate binding site [chemical binding]; other site
478435003245	putative catalytic residue [active]
478435003246	alanine dehydrogenase; Region: alaDH; TIGR00518
478435003247	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
478435003248	hexamer interface [polypeptide binding]; other site
478435003249	ligand binding site [chemical binding]; other site
478435003250	putative active site [active]
478435003251	NAD(P) binding site [chemical binding]; other site
478435003252	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
478435003253	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435003254	putative DNA binding site [nucleotide binding]; other site
478435003255	putative Zn2+ binding site [ion binding]; other site
478435003256	AsnC family; Region: AsnC_trans_reg; pfam01037
478435003257	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
478435003258	hydrophobic ligand binding site; other site
478435003259	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
478435003260	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
478435003261	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
478435003262	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
478435003263	FMN-binding pocket [chemical binding]; other site
478435003264	flavin binding motif; other site
478435003265	phosphate binding motif [ion binding]; other site
478435003266	beta-alpha-beta structure motif; other site
478435003267	NAD binding pocket [chemical binding]; other site
478435003268	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435003269	catalytic loop [active]
478435003270	iron binding site [ion binding]; other site
478435003271	putative transposase OrfB; Reviewed; Region: PHA02517
478435003272	HTH-like domain; Region: HTH_21; pfam13276
478435003273	Integrase core domain; Region: rve; pfam00665
478435003274	Integrase core domain; Region: rve_3; pfam13683
478435003275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435003276	Transposase; Region: HTH_Tnp_1; cl17663
478435003277	dihydrodipicolinate reductase; Provisional; Region: PRK00048
478435003278	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
478435003279	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
478435003280	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
478435003281	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435003282	PPE family; Region: PPE; pfam00823
478435003283	PE family; Region: PE; pfam00934
478435003284	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435003285	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435003286	PPE family; Region: PPE; pfam00823
478435003287	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435003288	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
478435003289	classical (c) SDRs; Region: SDR_c; cd05233
478435003290	NAD(P) binding site [chemical binding]; other site
478435003291	active site
478435003292	Dienelactone hydrolase family; Region: DLH; pfam01738
478435003293	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
478435003294	thymidylate synthase; Reviewed; Region: thyA; PRK01827
478435003295	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
478435003296	dimerization interface [polypeptide binding]; other site
478435003297	active site
478435003298	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
478435003299	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
478435003300	folate binding site [chemical binding]; other site
478435003301	NADP+ binding site [chemical binding]; other site
478435003302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
478435003303	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
478435003304	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
478435003305	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
478435003306	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
478435003307	putative active site [active]
478435003308	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435003309	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435003310	putative active site [active]
478435003311	HsdM N-terminal domain; Region: HsdM_N; pfam12161
478435003312	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
478435003313	Methyltransferase domain; Region: Methyltransf_26; pfam13659
478435003314	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
478435003315	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
478435003316	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
478435003317	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
478435003318	dimer interface [polypeptide binding]; other site
478435003319	active site
478435003320	catalytic residue [active]
478435003321	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
478435003322	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
478435003323	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
478435003324	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435003325	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435003326	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
478435003327	classical (c) SDRs; Region: SDR_c; cd05233
478435003328	NAD(P) binding site [chemical binding]; other site
478435003329	active site
478435003330	Uncharacterized conserved protein [Function unknown]; Region: COG1359
478435003331	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
478435003332	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435003333	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
478435003334	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435003335	Coenzyme A binding pocket [chemical binding]; other site
478435003336	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
478435003337	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435003338	non-specific DNA binding site [nucleotide binding]; other site
478435003339	salt bridge; other site
478435003340	sequence-specific DNA binding site [nucleotide binding]; other site
478435003341	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
478435003342	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
478435003343	PE family; Region: PE; pfam00934
478435003344	Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308
478435003345	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
478435003346	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
478435003347	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
478435003348	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
478435003349	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
478435003350	hexamer interface [polypeptide binding]; other site
478435003351	Walker A motif; other site
478435003352	ATP binding site [chemical binding]; other site
478435003353	Walker B motif; other site
478435003354	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
478435003355	protein-splicing catalytic site; other site
478435003356	thioester formation/cholesterol transfer; other site
478435003357	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
478435003358	recA bacterial DNA recombination protein; Region: RecA; cl17211
478435003359	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
478435003360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435003361	FeS/SAM binding site; other site
478435003362	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
478435003363	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
478435003364	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435003365	FeS/SAM binding site; other site
478435003366	TRAM domain; Region: TRAM; cl01282
478435003367	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
478435003368	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
478435003369	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
478435003370	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
478435003371	active site
478435003372	metal binding site [ion binding]; metal-binding site
478435003373	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
478435003374	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
478435003375	diaminopimelate epimerase; Region: DapF; TIGR00652
478435003376	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
478435003377	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
478435003378	GTPases [General function prediction only]; Region: HflX; COG2262
478435003379	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
478435003380	HflX GTPase family; Region: HflX; cd01878
478435003381	G1 box; other site
478435003382	GTP/Mg2+ binding site [chemical binding]; other site
478435003383	Switch I region; other site
478435003384	G2 box; other site
478435003385	G3 box; other site
478435003386	Switch II region; other site
478435003387	G4 box; other site
478435003388	G5 box; other site
478435003389	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435003390	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435003391	active site
478435003392	Integral membrane protein TerC family; Region: TerC; cl10468
478435003393	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
478435003394	LGFP repeat; Region: LGFP; pfam08310
478435003395	LGFP repeat; Region: LGFP; pfam08310
478435003396	LGFP repeat; Region: LGFP; pfam08310
478435003397	LGFP repeat; Region: LGFP; pfam08310
478435003398	LGFP repeat; Region: LGFP; pfam08310
478435003399	LexA repressor; Validated; Region: PRK00215
478435003400	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
478435003401	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
478435003402	Catalytic site [active]
478435003403	LysM domain; Region: LysM; pfam01476
478435003404	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
478435003405	ATP cone domain; Region: ATP-cone; pfam03477
478435003406	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
478435003407	heme-binding site [chemical binding]; other site
478435003408	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
478435003409	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435003410	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
478435003411	PAC2 family; Region: PAC2; pfam09754
478435003412	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
478435003413	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435003414	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435003415	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
478435003416	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
478435003417	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
478435003418	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
478435003419	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
478435003420	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
478435003421	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
478435003422	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
478435003423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435003424	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
478435003425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435003426	DNA binding residues [nucleotide binding]
478435003427	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
478435003428	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
478435003429	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
478435003430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
478435003431	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
478435003432	homotrimer interaction site [polypeptide binding]; other site
478435003433	putative active site [active]
478435003434	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
478435003435	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435003436	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
478435003437	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435003438	DNA binding residues [nucleotide binding]
478435003439	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
478435003440	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435003441	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
478435003442	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
478435003443	active site
478435003444	dimerization interface [polypeptide binding]; other site
478435003445	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
478435003446	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
478435003447	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
478435003448	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
478435003449	trimer interface [polypeptide binding]; other site
478435003450	active site
478435003451	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
478435003452	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
478435003453	generic binding surface II; other site
478435003454	ssDNA binding site; other site
478435003455	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
478435003456	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
478435003457	TrkA-N domain; Region: TrkA_N; pfam02254
478435003458	TrkA-C domain; Region: TrkA_C; pfam02080
478435003459	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
478435003460	TrkA-N domain; Region: TrkA_N; pfam02254
478435003461	TrkA-C domain; Region: TrkA_C; pfam02080
478435003462	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
478435003463	TRAM domain; Region: TRAM; cl01282
478435003464	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
478435003465	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
478435003466	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
478435003467	Walker A/P-loop; other site
478435003468	ATP binding site [chemical binding]; other site
478435003469	Q-loop/lid; other site
478435003470	ABC transporter signature motif; other site
478435003471	Walker B; other site
478435003472	D-loop; other site
478435003473	H-loop/switch region; other site
478435003474	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
478435003475	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
478435003476	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
478435003477	transmembrane helices; other site
478435003478	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
478435003479	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
478435003480	transmembrane helices; other site
478435003481	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
478435003482	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
478435003483	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
478435003484	TPP-binding site; other site
478435003485	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
478435003486	PYR/PP interface [polypeptide binding]; other site
478435003487	dimer interface [polypeptide binding]; other site
478435003488	TPP binding site [chemical binding]; other site
478435003489	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
478435003490	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
478435003491	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
478435003492	catalytic site [active]
478435003493	putative active site [active]
478435003494	putative substrate binding site [chemical binding]; other site
478435003495	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
478435003496	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435003497	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435003498	substrate binding site [chemical binding]; other site
478435003499	oxyanion hole (OAH) forming residues; other site
478435003500	trimer interface [polypeptide binding]; other site
478435003501	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
478435003502	substrate binding site [chemical binding]; other site
478435003503	active site
478435003504	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
478435003505	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435003506	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435003507	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
478435003508	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435003509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435003510	S-adenosylmethionine binding site [chemical binding]; other site
478435003511	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
478435003512	SelR domain; Region: SelR; pfam01641
478435003513	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
478435003514	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435003515	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435003516	hypothetical protein; Provisional; Region: PRK14059
478435003517	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
478435003518	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
478435003519	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
478435003520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435003521	Coenzyme A binding pocket [chemical binding]; other site
478435003522	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
478435003523	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435003524	MULE transposase domain; Region: MULE; pfam10551
478435003525	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
478435003526	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
478435003527	active site
478435003528	catalytic residues [active]
478435003529	DNA binding site [nucleotide binding]
478435003530	Int/Topo IB signature motif; other site
478435003531	DNA binding domain, excisionase family; Region: excise; TIGR01764
478435003532	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
478435003533	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
478435003534	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747
478435003535	Phage head maturation protease [General function prediction only]; Region: COG3740
478435003536	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
478435003537	Phage capsid family; Region: Phage_capsid; pfam05065
478435003538	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
478435003539	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435003540	active site
478435003541	DNA binding site [nucleotide binding]
478435003542	Int/Topo IB signature motif; other site
478435003543	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
478435003544	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
478435003545	arsenical-resistance protein; Region: acr3; TIGR00832
478435003546	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
478435003547	Low molecular weight phosphatase family; Region: LMWPc; cd00115
478435003548	active site
478435003549	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435003550	dimerization interface [polypeptide binding]; other site
478435003551	putative DNA binding site [nucleotide binding]; other site
478435003552	putative Zn2+ binding site [ion binding]; other site
478435003553	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
478435003554	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435003555	putative metal binding site [ion binding]; other site
478435003556	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435003557	Transcriptional regulators [Transcription]; Region: MarR; COG1846
478435003558	putative DNA binding site [nucleotide binding]; other site
478435003559	putative Zn2+ binding site [ion binding]; other site
478435003560	hypothetical protein; Provisional; Region: PRK02237
478435003561	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435003562	anti sigma factor interaction site; other site
478435003563	regulatory phosphorylation site [posttranslational modification]; other site
478435003564	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
478435003565	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
478435003566	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227
478435003567	P-loop motif; other site
478435003568	ATP binding site [chemical binding]; other site
478435003569	Chloramphenicol (Cm) binding site [chemical binding]; other site
478435003570	catalytic residue [active]
478435003571	PE family; Region: PE; pfam00934
478435003572	Hemerythrin-like domain; Region: Hr-like; cd12108
478435003573	Fe binding site [ion binding]; other site
478435003574	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
478435003575	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
478435003576	hypothetical protein; Reviewed; Region: PRK09588
478435003577	SHS2 domain protein implicated in nucleic acid metabolism [General function prediction    only]; Region: COG1371
478435003578	peptide chain release factor 1; Provisional; Region: PRK04011
478435003579	FOG: CBS domain [General function prediction only]; Region: COG0517
478435003580	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
478435003581	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
478435003582	active site
478435003583	Peptidase family M50; Region: Peptidase_M50; pfam02163
478435003584	putative substrate binding region [chemical binding]; other site
478435003585	FOG: CBS domain [General function prediction only]; Region: COG0517
478435003586	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
478435003587	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435003588	Ligand Binding Site [chemical binding]; other site
478435003589	Universal stress protein family; Region: Usp; pfam00582
478435003590	Ligand Binding Site [chemical binding]; other site
478435003591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435003592	Ligand Binding Site [chemical binding]; other site
478435003593	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435003594	Ligand Binding Site [chemical binding]; other site
478435003595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435003596	S-adenosylmethionine binding site [chemical binding]; other site
478435003597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435003598	Predicted transcriptional regulator [Transcription]; Region: COG2345
478435003599	Helix-turn-helix domain; Region: HTH_20; pfam12840
478435003600	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
478435003601	Helix-turn-helix domain; Region: HTH_20; pfam12840
478435003602	Predicted transcriptional regulator [Transcription]; Region: COG2345
478435003603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
478435003604	PE family; Region: PE; pfam00934
478435003605	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
478435003606	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
478435003607	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
478435003608	active site
478435003609	dimer interface [polypeptide binding]; other site
478435003610	motif 1; other site
478435003611	motif 2; other site
478435003612	motif 3; other site
478435003613	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
478435003614	anticodon binding site; other site
478435003615	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
478435003616	nucleotide binding site/active site [active]
478435003617	HIT family signature motif; other site
478435003618	catalytic residue [active]
478435003619	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
478435003620	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
478435003621	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
478435003622	putative acyl-acceptor binding pocket; other site
478435003623	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
478435003624	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
478435003625	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
478435003626	nudix motif; other site
478435003627	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435003628	PPE family; Region: PPE; pfam00823
478435003629	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435003630	PE-PPE domain; Region: PE-PPE; pfam08237
478435003631	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
478435003632	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
478435003633	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
478435003634	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
478435003635	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
478435003636	active site
478435003637	multimer interface [polypeptide binding]; other site
478435003638	acyl-CoA thioesterase II; Region: tesB; TIGR00189
478435003639	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
478435003640	active site
478435003641	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
478435003642	catalytic triad [active]
478435003643	dimer interface [polypeptide binding]; other site
478435003644	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
478435003645	predicted active site [active]
478435003646	catalytic triad [active]
478435003647	hypothetical protein; Validated; Region: PRK00110
478435003648	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435003649	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
478435003650	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
478435003651	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
478435003652	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
478435003653	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
478435003654	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
478435003655	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
478435003656	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435003657	putative active site [active]
478435003658	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
478435003659	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
478435003660	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
478435003661	active site
478435003662	putative DNA-binding cleft [nucleotide binding]; other site
478435003663	dimer interface [polypeptide binding]; other site
478435003664	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
478435003665	RuvA N terminal domain; Region: RuvA_N; pfam01330
478435003666	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
478435003667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435003668	Walker A motif; other site
478435003669	ATP binding site [chemical binding]; other site
478435003670	Walker B motif; other site
478435003671	arginine finger; other site
478435003672	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
478435003673	PE family; Region: PE; pfam00934
478435003674	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
478435003675	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435003676	acyl-activating enzyme (AAE) consensus motif; other site
478435003677	AMP binding site [chemical binding]; other site
478435003678	active site
478435003679	CoA binding site [chemical binding]; other site
478435003680	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
478435003681	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
478435003682	putative NAD(P) binding site [chemical binding]; other site
478435003683	active site
478435003684	putative substrate binding site [chemical binding]; other site
478435003685	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
478435003686	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
478435003687	inhibitor-cofactor binding pocket; inhibition site
478435003688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435003689	catalytic residue [active]
478435003690	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
478435003691	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
478435003692	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
478435003693	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
478435003694	Protein export membrane protein; Region: SecD_SecF; pfam02355
478435003695	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
478435003696	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
478435003697	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435003698	active site
478435003699	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
478435003700	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
478435003701	Zn2+ binding site [ion binding]; other site
478435003702	Mg2+ binding site [ion binding]; other site
478435003703	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
478435003704	synthetase active site [active]
478435003705	NTP binding site [chemical binding]; other site
478435003706	metal binding site [ion binding]; metal-binding site
478435003707	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
478435003708	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
478435003709	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
478435003710	active site
478435003711	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
478435003712	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
478435003713	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
478435003714	dimer interface [polypeptide binding]; other site
478435003715	motif 1; other site
478435003716	active site
478435003717	motif 2; other site
478435003718	motif 3; other site
478435003719	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
478435003720	anticodon binding site; other site
478435003721	haloalkane dehalogenase; Provisional; Region: PRK03592
478435003722	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
478435003723	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
478435003724	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
478435003725	active site
478435003726	metal binding site [ion binding]; metal-binding site
478435003727	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
478435003728	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
478435003729	putative hydrophobic ligand binding site [chemical binding]; other site
478435003730	protein interface [polypeptide binding]; other site
478435003731	gate; other site
478435003732	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
478435003733	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
478435003734	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
478435003735	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
478435003736	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
478435003737	dimer interface [polypeptide binding]; other site
478435003738	anticodon binding site; other site
478435003739	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
478435003740	homodimer interface [polypeptide binding]; other site
478435003741	motif 1; other site
478435003742	active site
478435003743	motif 2; other site
478435003744	GAD domain; Region: GAD; pfam02938
478435003745	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
478435003746	active site
478435003747	motif 3; other site
478435003748	Predicted membrane protein [Function unknown]; Region: COG4129
478435003749	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
478435003750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801
478435003751	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
478435003752	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
478435003753	Transglutaminase/protease-like homologues; Region: TGc; smart00460
478435003754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
478435003755	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
478435003756	Uncharacterized conserved protein [Function unknown]; Region: COG2308
478435003757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
478435003758	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
478435003759	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
478435003760	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
478435003761	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
478435003762	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
478435003763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
478435003764	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435003765	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435003766	ligand binding site [chemical binding]; other site
478435003767	flexible hinge region; other site
478435003768	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
478435003769	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
478435003770	active site
478435003771	nucleophile elbow; other site
478435003772	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
478435003773	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
478435003774	Walker A/P-loop; other site
478435003775	ATP binding site [chemical binding]; other site
478435003776	Q-loop/lid; other site
478435003777	ABC transporter signature motif; other site
478435003778	Walker B; other site
478435003779	D-loop; other site
478435003780	H-loop/switch region; other site
478435003781	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435003782	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435003783	ligand binding site [chemical binding]; other site
478435003784	flexible hinge region; other site
478435003785	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
478435003786	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
478435003787	Predicted integral membrane protein [Function unknown]; Region: COG5473
478435003788	recombination factor protein RarA; Reviewed; Region: PRK13342
478435003789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435003790	Walker A motif; other site
478435003791	ATP binding site [chemical binding]; other site
478435003792	Walker B motif; other site
478435003793	arginine finger; other site
478435003794	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
478435003795	Uncharacterized conserved protein [Function unknown]; Region: COG0432
478435003796	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
478435003797	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
478435003798	motif 1; other site
478435003799	active site
478435003800	motif 2; other site
478435003801	motif 3; other site
478435003802	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
478435003803	DHHA1 domain; Region: DHHA1; pfam02272
478435003804	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
478435003805	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
478435003806	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
478435003807	dimerization interface [polypeptide binding]; other site
478435003808	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
478435003809	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
478435003810	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
478435003811	NAD(P) binding site [chemical binding]; other site
478435003812	shikimate binding site; other site
478435003813	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
478435003814	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
478435003815	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435003816	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
478435003817	putative active site [active]
478435003818	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
478435003819	oligomeric interface; other site
478435003820	putative active site [active]
478435003821	homodimer interface [polypeptide binding]; other site
478435003822	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435003823	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435003824	putative active site [active]
478435003825	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435003826	digalactosyldiacylglycerol synthase; Region: PLN02846
478435003827	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
478435003828	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
478435003829	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
478435003830	Tetramer interface [polypeptide binding]; other site
478435003831	active site
478435003832	FMN-binding site [chemical binding]; other site
478435003833	shikimate kinase; Reviewed; Region: aroK; PRK00131
478435003834	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
478435003835	ADP binding site [chemical binding]; other site
478435003836	magnesium binding site [ion binding]; other site
478435003837	putative shikimate binding site; other site
478435003838	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
478435003839	active site
478435003840	dimer interface [polypeptide binding]; other site
478435003841	metal binding site [ion binding]; metal-binding site
478435003842	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
478435003843	Dehydroquinase class II; Region: DHquinase_II; pfam01220
478435003844	trimer interface [polypeptide binding]; other site
478435003845	active site
478435003846	dimer interface [polypeptide binding]; other site
478435003847	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
478435003848	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
478435003849	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
478435003850	active site
478435003851	elongation factor P; Validated; Region: PRK00529
478435003852	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
478435003853	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
478435003854	RNA binding site [nucleotide binding]; other site
478435003855	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
478435003856	RNA binding site [nucleotide binding]; other site
478435003857	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
478435003858	putative RNA binding site [nucleotide binding]; other site
478435003859	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
478435003860	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435003861	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435003862	catalytic residue [active]
478435003863	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
478435003864	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435003865	putative active site [active]
478435003866	ERCC4 domain; Region: ERCC4; pfam02732
478435003867	Lsr2; Region: Lsr2; pfam11774
478435003868	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
478435003869	Mrr N-terminal domain; Region: Mrr_N; pfam14338
478435003870	Restriction endonuclease; Region: Mrr_cat; pfam04471
478435003871	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435003872	putative active site [active]
478435003873	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
478435003874	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
478435003875	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
478435003876	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435003877	phosphate binding site [ion binding]; other site
478435003878	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
478435003879	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
478435003880	putative active site [active]
478435003881	putative catalytic site [active]
478435003882	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
478435003883	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435003884	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
478435003885	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
478435003886	putative NAD(P) binding site [chemical binding]; other site
478435003887	active site
478435003888	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
478435003889	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
478435003890	active site
478435003891	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
478435003892	hypothetical protein; Provisional; Region: PRK07907
478435003893	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
478435003894	active site
478435003895	metal binding site [ion binding]; metal-binding site
478435003896	dimer interface [polypeptide binding]; other site
478435003897	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
478435003898	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435003899	catalytic triad [active]
478435003900	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
478435003901	PE family; Region: PE; pfam00934
478435003902	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
478435003903	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
478435003904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
478435003905	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
478435003906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
478435003907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435003908	non-specific DNA binding site [nucleotide binding]; other site
478435003909	salt bridge; other site
478435003910	sequence-specific DNA binding site [nucleotide binding]; other site
478435003911	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
478435003912	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
478435003913	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435003914	MULE transposase domain; Region: MULE; pfam10551
478435003915	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
478435003916	catalytic site [active]
478435003917	putative active site [active]
478435003918	putative substrate binding site [chemical binding]; other site
478435003919	dimer interface [polypeptide binding]; other site
478435003920	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
478435003921	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
478435003922	classical (c) SDRs; Region: SDR_c; cd05233
478435003923	NAD(P) binding site [chemical binding]; other site
478435003924	active site
478435003925	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
478435003926	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435003927	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435003928	AMP-binding domain protein; Validated; Region: PRK08315
478435003929	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435003930	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
478435003931	acyl-activating enzyme (AAE) consensus motif; other site
478435003932	acyl-activating enzyme (AAE) consensus motif; other site
478435003933	putative AMP binding site [chemical binding]; other site
478435003934	putative active site [active]
478435003935	putative CoA binding site [chemical binding]; other site
478435003936	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
478435003937	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
478435003938	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
478435003939	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
478435003940	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
478435003941	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
478435003942	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435003943	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
478435003944	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
478435003945	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
478435003946	carboxyltransferase (CT) interaction site; other site
478435003947	biotinylation site [posttranslational modification]; other site
478435003948	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435003949	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435003950	active site
478435003951	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
478435003952	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
478435003953	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
478435003954	tetramer interface [polypeptide binding]; other site
478435003955	TPP-binding site [chemical binding]; other site
478435003956	heterodimer interface [polypeptide binding]; other site
478435003957	phosphorylation loop region [posttranslational modification]
478435003958	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
478435003959	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
478435003960	alpha subunit interface [polypeptide binding]; other site
478435003961	TPP binding site [chemical binding]; other site
478435003962	heterodimer interface [polypeptide binding]; other site
478435003963	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
478435003964	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
478435003965	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
478435003966	E3 interaction surface; other site
478435003967	lipoyl attachment site [posttranslational modification]; other site
478435003968	e3 binding domain; Region: E3_binding; pfam02817
478435003969	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
478435003970	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435003971	putative transposase OrfB; Reviewed; Region: PHA02517
478435003972	HTH-like domain; Region: HTH_21; pfam13276
478435003973	Integrase core domain; Region: rve; pfam00665
478435003974	Integrase core domain; Region: rve_3; pfam13683
478435003975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435003976	Transposase; Region: HTH_Tnp_1; cl17663
478435003977	TIGR00725 family protein; Region: TIGR00725
478435003978	PE family; Region: PE; pfam00934
478435003979	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435003980	cyclase homology domain; Region: CHD; cd07302
478435003981	nucleotidyl binding site; other site
478435003982	metal binding site [ion binding]; metal-binding site
478435003983	dimer interface [polypeptide binding]; other site
478435003984	Predicted ATPase [General function prediction only]; Region: COG3903
478435003985	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435003986	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435003987	DNA binding residues [nucleotide binding]
478435003988	dimerization interface [polypeptide binding]; other site
478435003989	PE family; Region: PE; pfam00934
478435003990	enoyl-CoA hydratase; Provisional; Region: PRK05870
478435003991	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435003992	substrate binding site [chemical binding]; other site
478435003993	oxyanion hole (OAH) forming residues; other site
478435003994	trimer interface [polypeptide binding]; other site
478435003995	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
478435003996	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435003997	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435003998	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435003999	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435004000	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
478435004001	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
478435004002	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435004003	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435004004	putative acyl-acceptor binding pocket; other site
478435004005	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
478435004006	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
478435004007	putative acyl-acceptor binding pocket; other site
478435004008	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
478435004009	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
478435004010	dimer interface [polypeptide binding]; other site
478435004011	ssDNA binding site [nucleotide binding]; other site
478435004012	tetramer (dimer of dimers) interface [polypeptide binding]; other site
478435004013	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
478435004014	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435004015	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435004016	ABC transporter; Region: ABC_tran_2; pfam12848
478435004017	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435004018	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
478435004019	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
478435004020	active site
478435004021	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
478435004022	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
478435004023	active site
478435004024	catalytic site [active]
478435004025	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
478435004026	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
478435004027	apolar tunnel; other site
478435004028	heme binding site [chemical binding]; other site
478435004029	dimerization interface [polypeptide binding]; other site
478435004030	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
478435004031	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435004032	active site
478435004033	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
478435004034	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
478435004035	Zn binding site [ion binding]; other site
478435004036	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
478435004037	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
478435004038	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
478435004039	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
478435004040	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
478435004041	putative DNA binding site [nucleotide binding]; other site
478435004042	catalytic residue [active]
478435004043	putative H2TH interface [polypeptide binding]; other site
478435004044	putative catalytic residues [active]
478435004045	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
478435004046	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
478435004047	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435004048	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435004049	trigger factor; Provisional; Region: tig; PRK01490
478435004050	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
478435004051	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
478435004052	Clp protease; Region: CLP_protease; pfam00574
478435004053	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
478435004054	oligomer interface [polypeptide binding]; other site
478435004055	active site residues [active]
478435004056	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
478435004057	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
478435004058	oligomer interface [polypeptide binding]; other site
478435004059	active site residues [active]
478435004060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435004061	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435004062	putative substrate translocation pore; other site
478435004063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435004064	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
478435004065	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
478435004066	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
478435004067	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
478435004068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435004069	Walker A motif; other site
478435004070	ATP binding site [chemical binding]; other site
478435004071	Walker B motif; other site
478435004072	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
478435004073	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
478435004074	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
478435004075	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
478435004076	dimer interface [polypeptide binding]; other site
478435004077	PYR/PP interface [polypeptide binding]; other site
478435004078	TPP binding site [chemical binding]; other site
478435004079	substrate binding site [chemical binding]; other site
478435004080	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
478435004081	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
478435004082	TPP-binding site [chemical binding]; other site
478435004083	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
478435004084	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
478435004085	GTP binding site; other site
478435004086	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
478435004087	Uncharacterized conserved protein [Function unknown]; Region: COG3268
478435004088	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
478435004089	NAD(P) binding pocket [chemical binding]; other site
478435004090	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
478435004091	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435004092	active site
478435004093	HIGH motif; other site
478435004094	nucleotide binding site [chemical binding]; other site
478435004095	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
478435004096	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
478435004097	active site
478435004098	KMSKS motif; other site
478435004099	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
478435004100	tRNA binding surface [nucleotide binding]; other site
478435004101	anticodon binding site; other site
478435004102	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
478435004103	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
478435004104	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
478435004105	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
478435004106	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
478435004107	active site
478435004108	multimer interface [polypeptide binding]; other site
478435004109	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
478435004110	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
478435004111	homodimer interface [polypeptide binding]; other site
478435004112	oligonucleotide binding site [chemical binding]; other site
478435004113	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
478435004114	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
478435004115	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
478435004116	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
478435004117	GTPase CgtA; Reviewed; Region: obgE; PRK12296
478435004118	GTP1/OBG; Region: GTP1_OBG; pfam01018
478435004119	Obg GTPase; Region: Obg; cd01898
478435004120	G1 box; other site
478435004121	GTP/Mg2+ binding site [chemical binding]; other site
478435004122	Switch I region; other site
478435004123	G2 box; other site
478435004124	G3 box; other site
478435004125	Switch II region; other site
478435004126	G4 box; other site
478435004127	G5 box; other site
478435004128	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
478435004129	gamma-glutamyl kinase; Provisional; Region: PRK05429
478435004130	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
478435004131	nucleotide binding site [chemical binding]; other site
478435004132	homotetrameric interface [polypeptide binding]; other site
478435004133	putative phosphate binding site [ion binding]; other site
478435004134	putative allosteric binding site; other site
478435004135	PUA domain; Region: PUA; pfam01472
478435004136	NAD synthetase; Reviewed; Region: nadE; PRK02628
478435004137	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
478435004138	multimer interface [polypeptide binding]; other site
478435004139	active site
478435004140	catalytic triad [active]
478435004141	protein interface 1 [polypeptide binding]; other site
478435004142	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
478435004143	homodimer interface [polypeptide binding]; other site
478435004144	NAD binding pocket [chemical binding]; other site
478435004145	ATP binding pocket [chemical binding]; other site
478435004146	Mg binding site [ion binding]; other site
478435004147	active-site loop [active]
478435004148	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
478435004149	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
478435004150	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
478435004151	substrate binding site [chemical binding]; other site
478435004152	dimer interface [polypeptide binding]; other site
478435004153	ATP binding site [chemical binding]; other site
478435004154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435004155	dimerization interface [polypeptide binding]; other site
478435004156	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
478435004157	cyclase homology domain; Region: CHD; cd07302
478435004158	nucleotidyl binding site; other site
478435004159	metal binding site [ion binding]; metal-binding site
478435004160	dimer interface [polypeptide binding]; other site
478435004161	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
478435004162	Mechanosensitive ion channel; Region: MS_channel; pfam00924
478435004163	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435004164	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435004165	ligand binding site [chemical binding]; other site
478435004166	flexible hinge region; other site
478435004167	PE family; Region: PE; pfam00934
478435004168	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004169	PPE family; Region: PPE; pfam00823
478435004170	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
478435004171	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
478435004172	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
478435004173	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
478435004174	dimer interface [polypeptide binding]; other site
478435004175	decamer (pentamer of dimers) interface [polypeptide binding]; other site
478435004176	catalytic triad [active]
478435004177	peroxidatic and resolving cysteines [active]
478435004178	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
478435004179	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
478435004180	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
478435004181	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
478435004182	putative catalytic cysteine [active]
478435004183	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
478435004184	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435004185	Walker A motif; other site
478435004186	ATP binding site [chemical binding]; other site
478435004187	Walker B motif; other site
478435004188	arginine finger; other site
478435004189	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
478435004190	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
478435004191	metal ion-dependent adhesion site (MIDAS); other site
478435004192	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435004193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
478435004194	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
478435004195	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435004196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435004197	S-adenosylmethionine binding site [chemical binding]; other site
478435004198	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
478435004199	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
478435004200	active site
478435004201	(T/H)XGH motif; other site
478435004202	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
478435004203	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435004204	catalytic core [active]
478435004205	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
478435004206	active site
478435004207	catalytic triad [active]
478435004208	oxyanion hole [active]
478435004209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
478435004210	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
478435004211	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
478435004212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435004213	Coenzyme A binding pocket [chemical binding]; other site
478435004214	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
478435004215	Helix-hairpin-helix motif; Region: HHH; pfam00633
478435004216	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
478435004217	Competence protein; Region: Competence; pfam03772
478435004218	hypothetical protein; Reviewed; Region: PRK07914
478435004219	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
478435004220	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
478435004221	Uncharacterized conserved protein [Function unknown]; Region: COG2308
478435004222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
478435004223	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
478435004224	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
478435004225	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
478435004226	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
478435004227	PE family; Region: PE; pfam00934
478435004228	ribonuclease Z; Reviewed; Region: PRK00055
478435004229	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
478435004230	FOG: CBS domain [General function prediction only]; Region: COG0517
478435004231	PemK-like protein; Region: PemK; pfam02452
478435004232	GTP-binding protein LepA; Provisional; Region: PRK05433
478435004233	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
478435004234	G1 box; other site
478435004235	putative GEF interaction site [polypeptide binding]; other site
478435004236	GTP/Mg2+ binding site [chemical binding]; other site
478435004237	Switch I region; other site
478435004238	G2 box; other site
478435004239	G3 box; other site
478435004240	Switch II region; other site
478435004241	G4 box; other site
478435004242	G5 box; other site
478435004243	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
478435004244	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
478435004245	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
478435004246	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435004247	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
478435004248	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
478435004249	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
478435004250	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
478435004251	sulfate transport protein; Provisional; Region: cysT; CHL00187
478435004252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435004253	dimer interface [polypeptide binding]; other site
478435004254	conserved gate region; other site
478435004255	putative PBP binding loops; other site
478435004256	ABC-ATPase subunit interface; other site
478435004257	sulfate transport protein; Provisional; Region: cysT; CHL00187
478435004258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435004259	dimer interface [polypeptide binding]; other site
478435004260	conserved gate region; other site
478435004261	putative PBP binding loops; other site
478435004262	ABC-ATPase subunit interface; other site
478435004263	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
478435004264	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
478435004265	Walker A/P-loop; other site
478435004266	ATP binding site [chemical binding]; other site
478435004267	Q-loop/lid; other site
478435004268	ABC transporter signature motif; other site
478435004269	Walker B; other site
478435004270	D-loop; other site
478435004271	H-loop/switch region; other site
478435004272	PE family; Region: PE; pfam00934
478435004273	Predicted membrane protein [Function unknown]; Region: COG1297
478435004274	putative oligopeptide transporter, OPT family; Region: TIGR00733
478435004275	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
478435004276	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
478435004277	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
478435004278	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
478435004279	putative active site [active]
478435004280	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
478435004281	putative active site [active]
478435004282	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
478435004283	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
478435004284	Active Sites [active]
478435004285	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
478435004286	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
478435004287	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
478435004288	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
478435004289	coproporphyrinogen III oxidase; Validated; Region: PRK05628
478435004290	Predicted permease [General function prediction only]; Region: COG3329
478435004291	salicylate synthase MbtI; Reviewed; Region: PRK07912
478435004292	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
478435004293	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
478435004294	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
478435004295	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
478435004296	acyl-activating enzyme (AAE) consensus motif; other site
478435004297	active site
478435004298	AMP binding site [chemical binding]; other site
478435004299	substrate binding site [chemical binding]; other site
478435004300	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
478435004301	Condensation domain; Region: Condensation; pfam00668
478435004302	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435004303	Nonribosomal peptide synthase; Region: NRPS; pfam08415
478435004304	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
478435004305	acyl-activating enzyme (AAE) consensus motif; other site
478435004306	AMP binding site [chemical binding]; other site
478435004307	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435004308	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
478435004309	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435004310	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
478435004311	active site
478435004312	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435004313	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435004314	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
478435004315	NADP binding site [chemical binding]; other site
478435004316	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435004317	active site
478435004318	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435004319	Condensation domain; Region: Condensation; pfam00668
478435004320	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435004321	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
478435004322	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
478435004323	acyl-activating enzyme (AAE) consensus motif; other site
478435004324	AMP binding site [chemical binding]; other site
478435004325	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435004326	Condensation domain; Region: Condensation; pfam00668
478435004327	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435004328	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
478435004329	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435004330	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
478435004331	Condensation domain; Region: Condensation; pfam00668
478435004332	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435004333	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
478435004334	acyl-activating enzyme (AAE) consensus motif; other site
478435004335	AMP binding site [chemical binding]; other site
478435004336	Condensation domain; Region: Condensation; pfam00668
478435004337	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
478435004338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435004339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
478435004340	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435004341	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
478435004342	chaperone protein DnaJ; Provisional; Region: PRK14278
478435004343	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
478435004344	HSP70 interaction site [polypeptide binding]; other site
478435004345	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
478435004346	Zn binding sites [ion binding]; other site
478435004347	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
478435004348	dimer interface [polypeptide binding]; other site
478435004349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
478435004350	RNA methyltransferase, RsmE family; Region: TIGR00046
478435004351	PE family; Region: PE; pfam00934
478435004352	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435004353	K homology RNA-binding domain; Region: KH; smart00322
478435004354	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
478435004355	PhoH-like protein; Region: PhoH; pfam02562
478435004356	metal-binding heat shock protein; Provisional; Region: PRK00016
478435004357	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
478435004358	Domain of unknown function DUF21; Region: DUF21; pfam01595
478435004359	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
478435004360	Transporter associated domain; Region: CorC_HlyC; smart01091
478435004361	GTPase Era; Reviewed; Region: era; PRK00089
478435004362	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
478435004363	G1 box; other site
478435004364	GTP/Mg2+ binding site [chemical binding]; other site
478435004365	Switch I region; other site
478435004366	G2 box; other site
478435004367	Switch II region; other site
478435004368	G3 box; other site
478435004369	G4 box; other site
478435004370	G5 box; other site
478435004371	KH domain; Region: KH_2; pfam07650
478435004372	amidase; Provisional; Region: PRK06061
478435004373	Amidase; Region: Amidase; pfam01425
478435004374	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
478435004375	Recombination protein O N terminal; Region: RecO_N; pfam11967
478435004376	Recombination protein O C terminal; Region: RecO_C; pfam02565
478435004377	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
478435004378	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
478435004379	catalytic residue [active]
478435004380	putative FPP diphosphate  binding site; other site
478435004381	putative FPP binding hydrophobic cleft; other site
478435004382	dimer interface [polypeptide binding]; other site
478435004383	putative IPP diphosphate binding site; other site
478435004384	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
478435004385	metal binding site 2 [ion binding]; metal-binding site
478435004386	putative DNA binding helix; other site
478435004387	metal binding site 1 [ion binding]; metal-binding site
478435004388	dimer interface [polypeptide binding]; other site
478435004389	structural Zn2+ binding site [ion binding]; other site
478435004390	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435004391	dimerization interface [polypeptide binding]; other site
478435004392	putative DNA binding site [nucleotide binding]; other site
478435004393	putative Zn2+ binding site [ion binding]; other site
478435004394	glycyl-tRNA synthetase; Provisional; Region: PRK04173
478435004395	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
478435004396	motif 1; other site
478435004397	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
478435004398	active site
478435004399	motif 2; other site
478435004400	motif 3; other site
478435004401	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
478435004402	anticodon binding site; other site
478435004403	PPE family; Region: PPE; pfam00823
478435004404	PPE family; Region: PPE; pfam00823
478435004405	PPE family; Region: PPE; pfam00823
478435004406	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004407	PPE family; Region: PPE; pfam00823
478435004408	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004409	PPE family; Region: PPE; pfam00823
478435004410	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
478435004411	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435004412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435004413	Transposase; Region: HTH_Tnp_1; cl17663
478435004414	putative transposase OrfB; Reviewed; Region: PHA02517
478435004415	HTH-like domain; Region: HTH_21; pfam13276
478435004416	Integrase core domain; Region: rve; pfam00665
478435004417	Integrase core domain; Region: rve_3; pfam13683
478435004418	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004419	PPE family; Region: PPE; pfam00823
478435004420	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
478435004421	Phosphoesterase family; Region: Phosphoesterase; pfam04185
478435004422	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
478435004423	Phosphoesterase family; Region: Phosphoesterase; pfam04185
478435004424	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
478435004425	Phosphoesterase family; Region: Phosphoesterase; pfam04185
478435004426	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
478435004427	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435004428	Repair protein; Region: Repair_PSII; pfam04536
478435004429	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
478435004430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
478435004431	Zn2+ binding site [ion binding]; other site
478435004432	Mg2+ binding site [ion binding]; other site
478435004433	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
478435004434	DNA primase; Validated; Region: dnaG; PRK05667
478435004435	CHC2 zinc finger; Region: zf-CHC2; pfam01807
478435004436	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
478435004437	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
478435004438	active site
478435004439	metal binding site [ion binding]; metal-binding site
478435004440	interdomain interaction site; other site
478435004441	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
478435004442	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
478435004443	PE family; Region: PE; pfam00934
478435004444	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435004445	hypothetical protein; Validated; Region: PRK08223
478435004446	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
478435004447	ATP binding site [chemical binding]; other site
478435004448	substrate interface [chemical binding]; other site
478435004449	hypothetical protein; Provisional; Region: PRK14851
478435004450	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
478435004451	serine O-acetyltransferase; Region: cysE; TIGR01172
478435004452	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
478435004453	trimer interface [polypeptide binding]; other site
478435004454	active site
478435004455	substrate binding site [chemical binding]; other site
478435004456	CoA binding site [chemical binding]; other site
478435004457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435004458	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435004459	putative substrate translocation pore; other site
478435004460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435004461	putative substrate translocation pore; other site
478435004462	malate dehydrogenase; Provisional; Region: PRK13529
478435004463	Malic enzyme, N-terminal domain; Region: malic; pfam00390
478435004464	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
478435004465	NAD(P) binding site [chemical binding]; other site
478435004466	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
478435004467	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435004468	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
478435004469	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
478435004470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435004471	putative substrate translocation pore; other site
478435004472	PE family; Region: PE; pfam00934
478435004473	MarR family; Region: MarR; pfam01047
478435004474	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435004475	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
478435004476	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
478435004477	Walker A/P-loop; other site
478435004478	ATP binding site [chemical binding]; other site
478435004479	Q-loop/lid; other site
478435004480	ABC transporter signature motif; other site
478435004481	Walker B; other site
478435004482	D-loop; other site
478435004483	H-loop/switch region; other site
478435004484	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
478435004485	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
478435004486	Walker A/P-loop; other site
478435004487	ATP binding site [chemical binding]; other site
478435004488	Q-loop/lid; other site
478435004489	ABC transporter signature motif; other site
478435004490	Walker B; other site
478435004491	D-loop; other site
478435004492	H-loop/switch region; other site
478435004493	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
478435004494	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
478435004495	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
478435004496	putative DNA binding site [nucleotide binding]; other site
478435004497	putative Zn2+ binding site [ion binding]; other site
478435004498	AsnC family; Region: AsnC_trans_reg; pfam01037
478435004499	Amidinotransferase; Region: Amidinotransf; pfam02274
478435004500	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
478435004501	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435004502	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435004503	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435004504	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
478435004505	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435004506	catalytic residue [active]
478435004507	amino acid transporter; Region: 2A0306; TIGR00909
478435004508	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
478435004509	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435004510	Ligand Binding Site [chemical binding]; other site
478435004511	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435004512	Ligand Binding Site [chemical binding]; other site
478435004513	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
478435004514	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
478435004515	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
478435004516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435004517	dimer interface [polypeptide binding]; other site
478435004518	conserved gate region; other site
478435004519	putative PBP binding loops; other site
478435004520	ABC-ATPase subunit interface; other site
478435004521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435004522	putative PBP binding loops; other site
478435004523	ABC-ATPase subunit interface; other site
478435004524	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
478435004525	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
478435004526	Uncharacterized conserved protein [Function unknown]; Region: COG2128
478435004527	Family description; Region: UvrD_C_2; pfam13538
478435004528	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
478435004529	DNA binding residues [nucleotide binding]
478435004530	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435004531	DNA binding site [nucleotide binding]
478435004532	active site
478435004533	Int/Topo IB signature motif; other site
478435004534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
478435004535	Uncharacterized conserved protein [Function unknown]; Region: COG2442
478435004536	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
478435004537	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435004538	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
478435004539	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
478435004540	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
478435004541	Cutinase; Region: Cutinase; pfam01083
478435004542	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
478435004543	heat shock protein 90; Provisional; Region: PRK05218
478435004544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435004545	ATP binding site [chemical binding]; other site
478435004546	Mg2+ binding site [ion binding]; other site
478435004547	G-X-G motif; other site
478435004548	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
478435004549	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
478435004550	active site
478435004551	catalytic tetrad [active]
478435004552	haloalkane dehalogenase; Provisional; Region: PRK00870
478435004553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196
478435004554	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
478435004555	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435004556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435004557	homodimer interface [polypeptide binding]; other site
478435004558	catalytic residue [active]
478435004559	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
478435004560	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
478435004561	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
478435004562	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
478435004563	active site residue [active]
478435004564	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
478435004565	active site residue [active]
478435004566	CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134
478435004567	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
478435004568	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
478435004569	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
478435004570	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435004571	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435004572	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435004573	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435004574	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435004575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435004576	Transposase; Region: HTH_Tnp_1; cl17663
478435004577	putative transposase OrfB; Reviewed; Region: PHA02517
478435004578	HTH-like domain; Region: HTH_21; pfam13276
478435004579	Integrase core domain; Region: rve; pfam00665
478435004580	Integrase core domain; Region: rve_3; pfam13683
478435004581	Transcriptional regulator [Transcription]; Region: LysR; COG0583
478435004582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
478435004583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
478435004584	dimerization interface [polypeptide binding]; other site
478435004585	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
478435004586	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
478435004587	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
478435004588	FAD binding domain; Region: FAD_binding_4; pfam01565
478435004589	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
478435004590	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
478435004591	putative active site [active]
478435004592	catalytic site [active]
478435004593	putative metal binding site [ion binding]; other site
478435004594	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435004595	Cytochrome P450; Region: p450; cl12078
478435004596	Domain of unknown function (DUF202); Region: DUF202; pfam02656
478435004597	Predicted membrane protein [Function unknown]; Region: COG2149
478435004598	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
478435004599	Septum formation; Region: Septum_form; pfam13845
478435004600	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435004601	Cytochrome P450; Region: p450; cl12078
478435004602	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
478435004603	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435004604	Cytochrome P450; Region: p450; cl12078
478435004605	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435004606	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
478435004607	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435004608	nucleotide binding site [chemical binding]; other site
478435004609	short chain dehydrogenase; Provisional; Region: PRK05854
478435004610	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
478435004611	putative NAD(P) binding site [chemical binding]; other site
478435004612	active site
478435004613	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
478435004614	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
478435004615	putative active site [active]
478435004616	catalytic triad [active]
478435004617	putative dimer interface [polypeptide binding]; other site
478435004618	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
478435004619	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
478435004620	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
478435004621	NAD binding site [chemical binding]; other site
478435004622	catalytic Zn binding site [ion binding]; other site
478435004623	substrate binding site [chemical binding]; other site
478435004624	structural Zn binding site [ion binding]; other site
478435004625	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435004626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435004627	S-adenosylmethionine binding site [chemical binding]; other site
478435004628	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435004629	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435004630	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
478435004631	diacylglycerol kinase; Reviewed; Region: PRK11914
478435004632	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
478435004633	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435004634	FAD binding domain; Region: FAD_binding_4; pfam01565
478435004635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435004636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435004637	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
478435004638	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
478435004639	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
478435004640	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
478435004641	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
478435004642	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
478435004643	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
478435004644	dimer interface [polypeptide binding]; other site
478435004645	active site
478435004646	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
478435004647	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
478435004648	dimer interface [polypeptide binding]; other site
478435004649	active site
478435004650	acyl carrier protein; Provisional; Region: acpP; PRK00982
478435004651	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
478435004652	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435004653	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435004654	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
478435004655	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
478435004656	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
478435004657	dimer interface [polypeptide binding]; other site
478435004658	TPP-binding site [chemical binding]; other site
478435004659	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
478435004660	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
478435004661	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
478435004662	dimer interface [polypeptide binding]; other site
478435004663	catalytic triad [active]
478435004664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
478435004665	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
478435004666	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
478435004667	Low molecular weight phosphatase family; Region: LMWPc; cd00115
478435004668	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
478435004669	active site
478435004670	phosphoglycolate phosphatase; Provisional; Region: PRK13222
478435004671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435004672	active site
478435004673	motif I; other site
478435004674	motif II; other site
478435004675	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
478435004676	hypothetical protein; Provisional; Region: PRK07908
478435004677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435004678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435004679	homodimer interface [polypeptide binding]; other site
478435004680	catalytic residue [active]
478435004681	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
478435004682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
478435004683	Uncharacterized conserved protein [Function unknown]; Region: COG0327
478435004684	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
478435004685	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
478435004686	Putative zinc ribbon domain; Region: DUF164; pfam02591
478435004687	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
478435004688	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
478435004689	RNA/DNA hybrid binding site [nucleotide binding]; other site
478435004690	active site
478435004691	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435004692	catalytic core [active]
478435004693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
478435004694	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
478435004695	putative active site; other site
478435004696	putative metal binding residues [ion binding]; other site
478435004697	signature motif; other site
478435004698	putative triphosphate binding site [ion binding]; other site
478435004699	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
478435004700	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
478435004701	oligomerization interface [polypeptide binding]; other site
478435004702	active site
478435004703	metal binding site [ion binding]; metal-binding site
478435004704	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
478435004705	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435004706	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
478435004707	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435004708	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
478435004709	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
478435004710	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
478435004711	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
478435004712	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
478435004713	metal binding triad; other site
478435004714	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
478435004715	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
478435004716	metal binding triad; other site
478435004717	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
478435004718	glutamine synthetase, type I; Region: GlnA; TIGR00653
478435004719	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
478435004720	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
478435004721	RDD family; Region: RDD; pfam06271
478435004722	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
478435004723	lipoyl synthase; Provisional; Region: PRK05481
478435004724	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435004725	FeS/SAM binding site; other site
478435004726	lipoate-protein ligase B; Provisional; Region: PRK14345
478435004727	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
478435004728	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
478435004729	putative NAD(P) binding site [chemical binding]; other site
478435004730	putative active site [active]
478435004731	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
478435004732	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
478435004733	E3 interaction surface; other site
478435004734	lipoyl attachment site [posttranslational modification]; other site
478435004735	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
478435004736	E3 interaction surface; other site
478435004737	lipoyl attachment site [posttranslational modification]; other site
478435004738	e3 binding domain; Region: E3_binding; pfam02817
478435004739	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
478435004740	short chain dehydrogenase; Validated; Region: PRK05855
478435004741	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435004742	classical (c) SDRs; Region: SDR_c; cd05233
478435004743	NAD(P) binding site [chemical binding]; other site
478435004744	active site
478435004745	multifunctional aminopeptidase A; Provisional; Region: PRK00913
478435004746	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
478435004747	interface (dimer of trimers) [polypeptide binding]; other site
478435004748	Substrate-binding/catalytic site; other site
478435004749	Zn-binding sites [ion binding]; other site
478435004750	cyclase homology domain; Region: CHD; cd07302
478435004751	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435004752	nucleotidyl binding site; other site
478435004753	metal binding site [ion binding]; metal-binding site
478435004754	dimer interface [polypeptide binding]; other site
478435004755	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
478435004756	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
478435004757	Cobalamin-5-phosphate synthase; Region: CobS; pfam02654
478435004758	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
478435004759	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
478435004760	putative dimer interface [polypeptide binding]; other site
478435004761	active site pocket [active]
478435004762	putative cataytic base [active]
478435004763	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
478435004764	Glycerate kinase family; Region: Gly_kinase; cl00841
478435004765	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
478435004766	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
478435004767	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
478435004768	substrate binding site [chemical binding]; other site
478435004769	ATP binding site [chemical binding]; other site
478435004770	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
478435004771	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
478435004772	dimer interface [polypeptide binding]; other site
478435004773	active site
478435004774	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
478435004775	Ligand Binding Site [chemical binding]; other site
478435004776	Molecular Tunnel; other site
478435004777	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
478435004778	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
478435004779	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
478435004780	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
478435004781	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
478435004782	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
478435004783	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
478435004784	heme bH binding site [chemical binding]; other site
478435004785	intrachain domain interface; other site
478435004786	heme bL binding site [chemical binding]; other site
478435004787	interchain domain interface [polypeptide binding]; other site
478435004788	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
478435004789	Qo binding site; other site
478435004790	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
478435004791	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
478435004792	iron-sulfur cluster [ion binding]; other site
478435004793	[2Fe-2S] cluster binding site [ion binding]; other site
478435004794	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
478435004795	Cytochrome c; Region: Cytochrom_C; pfam00034
478435004796	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
478435004797	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
478435004798	Subunit I/III interface [polypeptide binding]; other site
478435004799	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
478435004800	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
478435004801	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
478435004802	hypothetical protein; Validated; Region: PRK07883
478435004803	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
478435004804	active site
478435004805	catalytic site [active]
478435004806	substrate binding site [chemical binding]; other site
478435004807	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
478435004808	GIY-YIG motif/motif A; other site
478435004809	active site
478435004810	catalytic site [active]
478435004811	putative DNA binding site [nucleotide binding]; other site
478435004812	metal binding site [ion binding]; metal-binding site
478435004813	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
478435004814	NlpC/P60 family; Region: NLPC_P60; pfam00877
478435004815	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
478435004816	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
478435004817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
478435004818	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
478435004819	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
478435004820	acyl-activating enzyme (AAE) consensus motif; other site
478435004821	putative AMP binding site [chemical binding]; other site
478435004822	putative active site [active]
478435004823	putative CoA binding site [chemical binding]; other site
478435004824	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
478435004825	putative hydrophobic ligand binding site [chemical binding]; other site
478435004826	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
478435004827	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
478435004828	DTAP/Switch II; other site
478435004829	Switch I; other site
478435004830	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435004831	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435004832	putative acyl-acceptor binding pocket; other site
478435004833	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
478435004834	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
478435004835	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
478435004836	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
478435004837	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435004838	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435004839	active site
478435004840	ATP binding site [chemical binding]; other site
478435004841	substrate binding site [chemical binding]; other site
478435004842	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
478435004843	substrate binding site [chemical binding]; other site
478435004844	activation loop (A-loop); other site
478435004845	activation loop (A-loop); other site
478435004846	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
478435004847	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
478435004848	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
478435004849	substrate binding pocket [chemical binding]; other site
478435004850	chain length determination region; other site
478435004851	substrate-Mg2+ binding site; other site
478435004852	catalytic residues [active]
478435004853	aspartate-rich region 1; other site
478435004854	active site lid residues [active]
478435004855	aspartate-rich region 2; other site
478435004856	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
478435004857	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
478435004858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
478435004859	MraZ protein; Region: MraZ; pfam02381
478435004860	MraZ protein; Region: MraZ; pfam02381
478435004861	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
478435004862	MraW methylase family; Region: Methyltransf_5; pfam01795
478435004863	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
478435004864	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
478435004865	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
478435004866	PE family; Region: PE; pfam00934
478435004867	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
478435004868	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435004869	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435004870	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435004871	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
478435004872	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
478435004873	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
478435004874	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
478435004875	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
478435004876	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
478435004877	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
478435004878	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
478435004879	Mg++ binding site [ion binding]; other site
478435004880	putative catalytic motif [active]
478435004881	putative substrate binding site [chemical binding]; other site
478435004882	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
478435004883	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
478435004884	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
478435004885	cell division protein FtsW; Region: ftsW; TIGR02614
478435004886	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
478435004887	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
478435004888	active site
478435004889	homodimer interface [polypeptide binding]; other site
478435004890	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
478435004891	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
478435004892	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
478435004893	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
478435004894	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
478435004895	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
478435004896	Cell division protein FtsQ; Region: FtsQ; pfam03799
478435004897	cell division protein FtsZ; Validated; Region: PRK09330
478435004898	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
478435004899	nucleotide binding site [chemical binding]; other site
478435004900	SulA interaction site; other site
478435004901	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
478435004902	uncharacterized protein, YfiH family; Region: TIGR00726
478435004903	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
478435004904	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
478435004905	catalytic residue [active]
478435004906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
478435004907	Predicted integral membrane protein [Function unknown]; Region: COG0762
478435004908	DivIVA domain; Region: DivI1A_domain; TIGR03544
478435004909	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
478435004910	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
478435004911	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435004912	active site
478435004913	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
478435004914	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
478435004915	hypothetical protein; Provisional; Region: PRK07906
478435004916	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
478435004917	putative metal binding site [ion binding]; other site
478435004918	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
478435004919	substrate binding site [chemical binding]; other site
478435004920	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
478435004921	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
478435004922	quinone interaction residues [chemical binding]; other site
478435004923	active site
478435004924	catalytic residues [active]
478435004925	FMN binding site [chemical binding]; other site
478435004926	substrate binding site [chemical binding]; other site
478435004927	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
478435004928	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435004929	catalytic core [active]
478435004930	conserved hypothetical protein; Region: TIGR03847
478435004931	conserved hypothetical protein; Region: TIGR03843
478435004932	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435004933	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
478435004934	active site
478435004935	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
478435004936	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
478435004937	active site
478435004938	HIGH motif; other site
478435004939	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435004940	active site
478435004941	KMSKS motif; other site
478435004942	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
478435004943	putative tRNA binding surface [nucleotide binding]; other site
478435004944	short chain dehydrogenase; Provisional; Region: PRK05872
478435004945	classical (c) SDRs; Region: SDR_c; cd05233
478435004946	NAD(P) binding site [chemical binding]; other site
478435004947	active site
478435004948	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
478435004949	PAC2 family; Region: PAC2; pfam09754
478435004950	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
478435004951	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
478435004952	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
478435004953	substrate binding pocket [chemical binding]; other site
478435004954	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
478435004955	B12 binding site [chemical binding]; other site
478435004956	cobalt ligand [ion binding]; other site
478435004957	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
478435004958	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004959	PPE family; Region: PPE; pfam00823
478435004960	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
478435004961	homodimer interface [polypeptide binding]; other site
478435004962	putative metal binding site [ion binding]; other site
478435004963	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
478435004964	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
478435004965	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
478435004966	Predicted membrane protein [Function unknown]; Region: COG3918
478435004967	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
478435004968	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
478435004969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435004970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
478435004971	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
478435004972	proteasome ATPase; Region: pup_AAA; TIGR03689
478435004973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435004974	Walker A motif; other site
478435004975	ATP binding site [chemical binding]; other site
478435004976	Walker B motif; other site
478435004977	arginine finger; other site
478435004978	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
478435004979	Pup-like protein; Region: Pup; pfam05639
478435004980	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
478435004981	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
478435004982	active site
478435004983	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
478435004984	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
478435004985	active site
478435004986	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435004987	PPE family; Region: PPE; pfam00823
478435004988	PE family; Region: PE; pfam00934
478435004989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435004990	Transposase; Region: HTH_Tnp_1; cl17663
478435004991	putative transposase OrfB; Reviewed; Region: PHA02517
478435004992	HTH-like domain; Region: HTH_21; pfam13276
478435004993	Integrase core domain; Region: rve; pfam00665
478435004994	Integrase core domain; Region: rve_3; pfam13683
478435004995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435004996	Transposase; Region: HTH_Tnp_1; cl17663
478435004997	putative transposase OrfB; Reviewed; Region: PHA02517
478435004998	HTH-like domain; Region: HTH_21; pfam13276
478435004999	Integrase core domain; Region: rve; pfam00665
478435005000	Integrase core domain; Region: rve_3; pfam13683
478435005001	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435005002	putative active site [active]
478435005003	Uncharacterized conserved protein [Function unknown]; Region: COG4279
478435005004	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
478435005005	SNF2 Helicase protein; Region: DUF3670; pfam12419
478435005006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435005007	ATP binding site [chemical binding]; other site
478435005008	putative Mg++ binding site [ion binding]; other site
478435005009	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435005010	nucleotide binding region [chemical binding]; other site
478435005011	ATP-binding site [chemical binding]; other site
478435005012	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435005013	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435005014	active site
478435005015	PE family; Region: PE; pfam00934
478435005016	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
478435005017	Predicted transcriptional regulator [Transcription]; Region: COG2378
478435005018	WYL domain; Region: WYL; pfam13280
478435005019	Predicted transcriptional regulator [Transcription]; Region: COG2378
478435005020	WYL domain; Region: WYL; pfam13280
478435005021	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
478435005022	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
478435005023	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
478435005024	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
478435005025	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435005026	ATP binding site [chemical binding]; other site
478435005027	putative Mg++ binding site [ion binding]; other site
478435005028	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435005029	nucleotide binding region [chemical binding]; other site
478435005030	ATP-binding site [chemical binding]; other site
478435005031	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
478435005032	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
478435005033	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
478435005034	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
478435005035	active site
478435005036	metal binding site 1 [ion binding]; metal-binding site
478435005037	putative 5' ssDNA interaction site; other site
478435005038	metal binding site 3; metal-binding site
478435005039	metal binding site 2 [ion binding]; metal-binding site
478435005040	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
478435005041	putative DNA binding site [nucleotide binding]; other site
478435005042	putative metal binding site [ion binding]; other site
478435005043	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
478435005044	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
478435005045	active site
478435005046	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435005047	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435005048	active site
478435005049	ATP binding site [chemical binding]; other site
478435005050	substrate binding site [chemical binding]; other site
478435005051	activation loop (A-loop); other site
478435005052	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435005053	putative transposase OrfB; Reviewed; Region: PHA02517
478435005054	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
478435005055	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
478435005056	putative active site [active]
478435005057	catalytic site [active]
478435005058	putative metal binding site [ion binding]; other site
478435005059	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
478435005060	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
478435005061	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005062	NAD(P) binding site [chemical binding]; other site
478435005063	active site
478435005064	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
478435005065	active site
478435005066	putative homodimer interface [polypeptide binding]; other site
478435005067	SAM binding site [chemical binding]; other site
478435005068	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
478435005069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435005070	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
478435005071	active site
478435005072	SAM binding site [chemical binding]; other site
478435005073	homodimer interface [polypeptide binding]; other site
478435005074	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
478435005075	precorrin-6x reductase; Region: precor6x_red; TIGR00715
478435005076	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
478435005077	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435005078	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435005079	DNA binding residues [nucleotide binding]
478435005080	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
478435005081	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
478435005082	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435005083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435005084	S-adenosylmethionine binding site [chemical binding]; other site
478435005085	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
478435005086	active site
478435005087	SAM binding site [chemical binding]; other site
478435005088	homodimer interface [polypeptide binding]; other site
478435005089	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
478435005090	active site
478435005091	SAM binding site [chemical binding]; other site
478435005092	homodimer interface [polypeptide binding]; other site
478435005093	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
478435005094	Precorrin-8X methylmutase; Region: CbiC; pfam02570
478435005095	precorrin-3B synthase; Region: CobG; TIGR02435
478435005096	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
478435005097	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
478435005098	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
478435005099	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
478435005100	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
478435005101	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
478435005102	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
478435005103	intersubunit interface [polypeptide binding]; other site
478435005104	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
478435005105	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
478435005106	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
478435005107	30S ribosomal protein S18; Provisional; Region: PRK13401
478435005108	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
478435005109	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
478435005110	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
478435005111	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
478435005112	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
478435005113	active site
478435005114	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
478435005115	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
478435005116	putative active site [active]
478435005117	catalytic triad [active]
478435005118	putative dimer interface [polypeptide binding]; other site
478435005119	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
478435005120	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
478435005121	Ligand binding site; other site
478435005122	Putative Catalytic site; other site
478435005123	DXD motif; other site
478435005124	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
478435005125	potential frameshift: common BLAST hit: gi|385998828|ref|YP_005917126.1| polyketide synthase
478435005126	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435005127	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435005128	active site
478435005129	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435005130	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435005131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005132	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
478435005133	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435005134	Enoylreductase; Region: PKS_ER; smart00829
478435005135	NAD(P) binding site [chemical binding]; other site
478435005136	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
478435005137	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435005138	putative NADP binding site [chemical binding]; other site
478435005139	active site
478435005140	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435005141	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435005142	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435005143	active site
478435005144	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435005145	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435005146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005147	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435005148	Enoylreductase; Region: PKS_ER; smart00829
478435005149	NAD(P) binding site [chemical binding]; other site
478435005150	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
478435005151	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435005152	putative NADP binding site [chemical binding]; other site
478435005153	active site
478435005154	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435005155	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
478435005156	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435005157	substrate binding pocket [chemical binding]; other site
478435005158	catalytic triad [active]
478435005159	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
478435005160	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
478435005161	Isochorismatase family; Region: Isochorismatase; pfam00857
478435005162	catalytic triad [active]
478435005163	metal binding site [ion binding]; metal-binding site
478435005164	conserved cis-peptide bond; other site
478435005165	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
478435005166	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
478435005167	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
478435005168	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
478435005169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435005170	dimer interface [polypeptide binding]; other site
478435005171	conserved gate region; other site
478435005172	putative PBP binding loops; other site
478435005173	ABC-ATPase subunit interface; other site
478435005174	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
478435005175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435005176	dimer interface [polypeptide binding]; other site
478435005177	conserved gate region; other site
478435005178	putative PBP binding loops; other site
478435005179	ABC-ATPase subunit interface; other site
478435005180	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
478435005181	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
478435005182	Walker A/P-loop; other site
478435005183	ATP binding site [chemical binding]; other site
478435005184	Q-loop/lid; other site
478435005185	ABC transporter signature motif; other site
478435005186	Walker B; other site
478435005187	D-loop; other site
478435005188	H-loop/switch region; other site
478435005189	TOBE domain; Region: TOBE_2; pfam08402
478435005190	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
478435005191	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
478435005192	nucleophile elbow; other site
478435005193	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
478435005194	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435005195	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
478435005196	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
478435005197	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
478435005198	putative hydrophobic ligand binding site [chemical binding]; other site
478435005199	CLM binding site; other site
478435005200	L1 loop; other site
478435005201	DNA binding site [nucleotide binding]
478435005202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435005203	putative DNA binding site [nucleotide binding]; other site
478435005204	dimerization interface [polypeptide binding]; other site
478435005205	putative Zn2+ binding site [ion binding]; other site
478435005206	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
478435005207	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
478435005208	dimer interface [polypeptide binding]; other site
478435005209	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
478435005210	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
478435005211	putative dimer interface [polypeptide binding]; other site
478435005212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435005213	active site
478435005214	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
478435005215	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
478435005216	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
478435005217	putative substrate binding site [chemical binding]; other site
478435005218	putative ATP binding site [chemical binding]; other site
478435005219	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005220	Ligand Binding Site [chemical binding]; other site
478435005221	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
478435005222	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
478435005223	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
478435005224	Histidine kinase; Region: HisKA_3; pfam07730
478435005225	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005226	Ligand Binding Site [chemical binding]; other site
478435005227	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005228	Ligand Binding Site [chemical binding]; other site
478435005229	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
478435005230	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
478435005231	Predicted helicase [General function prediction only]; Region: COG4889
478435005232	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
478435005233	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
478435005234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435005235	ATP binding site [chemical binding]; other site
478435005236	putative Mg++ binding site [ion binding]; other site
478435005237	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
478435005238	ATP-binding site [chemical binding]; other site
478435005239	Methyltransferase domain; Region: Methyltransf_26; pfam13659
478435005240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
478435005241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435005242	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435005243	non-specific DNA binding site [nucleotide binding]; other site
478435005244	salt bridge; other site
478435005245	sequence-specific DNA binding site [nucleotide binding]; other site
478435005246	Predicted helicase [General function prediction only]; Region: COG4889
478435005247	putative transposase OrfB; Reviewed; Region: PHA02517
478435005248	HTH-like domain; Region: HTH_21; pfam13276
478435005249	Integrase core domain; Region: rve; pfam00665
478435005250	Integrase core domain; Region: rve_3; pfam13683
478435005251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435005252	Transposase; Region: HTH_Tnp_1; cl17663
478435005253	Uncharacterized conserved protein [Function unknown]; Region: COG2442
478435005254	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435005255	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435005256	non-specific DNA binding site [nucleotide binding]; other site
478435005257	salt bridge; other site
478435005258	sequence-specific DNA binding site [nucleotide binding]; other site
478435005259	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
478435005260	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435005261	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435005262	active site
478435005263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
478435005264	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
478435005265	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435005266	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
478435005267	Phage envelope protein [General function prediction only]; Region: COG5562
478435005268	Transcriptional regulators [Transcription]; Region: MarR; COG1846
478435005269	MarR family; Region: MarR_2; pfam12802
478435005270	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435005271	putative active site [active]
478435005272	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435005273	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
478435005274	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
478435005275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435005276	Walker A motif; other site
478435005277	ATP binding site [chemical binding]; other site
478435005278	Walker B motif; other site
478435005279	arginine finger; other site
478435005280	Ferredoxin [Energy production and conversion]; Region: COG1146
478435005281	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
478435005282	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
478435005283	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
478435005284	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
478435005285	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
478435005286	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
478435005287	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
478435005288	Universal stress protein family; Region: Usp; pfam00582
478435005289	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005290	Ligand Binding Site [chemical binding]; other site
478435005291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
478435005292	Predicted kinase [General function prediction only]; Region: COG0645
478435005293	AAA domain; Region: AAA_17; pfam13207
478435005294	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435005295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435005296	S-adenosylmethionine binding site [chemical binding]; other site
478435005297	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
478435005298	homotetramer interface [polypeptide binding]; other site
478435005299	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
478435005300	NAD binding site [chemical binding]; other site
478435005301	homodimer interface [polypeptide binding]; other site
478435005302	active site
478435005303	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
478435005304	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435005305	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
478435005306	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
478435005307	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
478435005308	tetramer interface [polypeptide binding]; other site
478435005309	active site
478435005310	Mg2+/Mn2+ binding site [ion binding]; other site
478435005311	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
478435005312	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
478435005313	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435005314	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
478435005315	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435005316	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
478435005317	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005318	Ligand Binding Site [chemical binding]; other site
478435005319	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435005320	Ligand Binding Site [chemical binding]; other site
478435005321	Hemerythrin-like domain; Region: Hr-like; cd12108
478435005322	Fe binding site [ion binding]; other site
478435005323	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435005324	dimerization interface [polypeptide binding]; other site
478435005325	putative DNA binding site [nucleotide binding]; other site
478435005326	putative Zn2+ binding site [ion binding]; other site
478435005327	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
478435005328	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
478435005329	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435005330	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435005331	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435005332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005333	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
478435005334	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
478435005335	Uncharacterized conserved protein [Function unknown]; Region: COG5654
478435005336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435005337	S-adenosylmethionine binding site [chemical binding]; other site
478435005338	Cellulose binding domain; Region: CBM_2; pfam00553
478435005339	Lysine efflux permease [General function prediction only]; Region: COG1279
478435005340	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
478435005341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
478435005342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
478435005343	dimerization interface [polypeptide binding]; other site
478435005344	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
478435005345	Cutinase; Region: Cutinase; pfam01083
478435005346	PE family; Region: PE; pfam00934
478435005347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
478435005348	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
478435005349	putative active site [active]
478435005350	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
478435005351	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
478435005352	dimer interface [polypeptide binding]; other site
478435005353	putative radical transfer pathway; other site
478435005354	diiron center [ion binding]; other site
478435005355	tyrosyl radical; other site
478435005356	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
478435005357	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
478435005358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435005359	S-adenosylmethionine binding site [chemical binding]; other site
478435005360	Peptidase family M48; Region: Peptidase_M48; pfam01435
478435005361	YacP-like NYN domain; Region: NYN_YacP; cl01491
478435005362	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
478435005363	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435005364	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005365	mce related protein; Region: MCE; pfam02470
478435005366	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005367	mce related protein; Region: MCE; pfam02470
478435005368	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005369	mce related protein; Region: MCE; pfam02470
478435005370	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005371	mce related protein; Region: MCE; pfam02470
478435005372	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005373	mce related protein; Region: MCE; pfam02470
478435005374	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435005375	mce related protein; Region: MCE; pfam02470
478435005376	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435005377	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435005378	Permease; Region: Permease; pfam02405
478435005379	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435005380	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435005381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435005382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435005383	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435005384	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
478435005385	putative active site [active]
478435005386	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
478435005387	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
478435005388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435005389	non-specific DNA binding site [nucleotide binding]; other site
478435005390	salt bridge; other site
478435005391	sequence-specific DNA binding site [nucleotide binding]; other site
478435005392	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
478435005393	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
478435005394	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
478435005395	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435005396	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435005397	active site
478435005398	SEC-C motif; Region: SEC-C; pfam02810
478435005399	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435005400	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
478435005401	putative NAD(P) binding site [chemical binding]; other site
478435005402	active site
478435005403	homodimer interface [polypeptide binding]; other site
478435005404	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
478435005405	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
478435005406	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
478435005407	dimerization interface [polypeptide binding]; other site
478435005408	active site
478435005409	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
478435005410	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435005411	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435005412	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
478435005413	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435005414	catalytic loop [active]
478435005415	iron binding site [ion binding]; other site
478435005416	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
478435005417	FAD binding pocket [chemical binding]; other site
478435005418	FAD binding motif [chemical binding]; other site
478435005419	phosphate binding motif [ion binding]; other site
478435005420	beta-alpha-beta structure motif; other site
478435005421	NAD binding pocket [chemical binding]; other site
478435005422	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435005423	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
478435005424	enoyl-CoA hydratase; Provisional; Region: PRK08290
478435005425	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435005426	substrate binding site [chemical binding]; other site
478435005427	oxyanion hole (OAH) forming residues; other site
478435005428	trimer interface [polypeptide binding]; other site
478435005429	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435005430	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
478435005431	FAD binding site [chemical binding]; other site
478435005432	substrate binding site [chemical binding]; other site
478435005433	catalytic base [active]
478435005434	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435005435	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
478435005436	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
478435005437	active site
478435005438	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
478435005439	dimer interface [polypeptide binding]; other site
478435005440	catalytic triad [active]
478435005441	peroxidatic and resolving cysteines [active]
478435005442	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
478435005443	conserved cys residue [active]
478435005444	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
478435005445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
478435005446	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
478435005447	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
478435005448	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
478435005449	TIGR03085 family protein; Region: TIGR03085
478435005450	short chain dehydrogenase; Provisional; Region: PRK05867
478435005451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005452	NAD(P) binding site [chemical binding]; other site
478435005453	active site
478435005454	Uncharacterized conserved protein [Function unknown]; Region: COG3361
478435005455	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
478435005456	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
478435005457	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435005458	acyl-activating enzyme (AAE) consensus motif; other site
478435005459	active site
478435005460	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435005461	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435005462	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435005463	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435005464	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
478435005465	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435005466	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
478435005467	putative acyl-acceptor binding pocket; other site
478435005468	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
478435005469	putative hydrophobic ligand binding site [chemical binding]; other site
478435005470	protein interface [polypeptide binding]; other site
478435005471	gate; other site
478435005472	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005473	PPE family; Region: PPE; pfam00823
478435005474	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005475	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005476	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005477	PPE family; Region: PPE; pfam00823
478435005478	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005479	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005480	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005481	Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224
478435005482	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
478435005483	tetramer interface [polypeptide binding]; other site
478435005484	active site
478435005485	Mg2+/Mn2+ binding site [ion binding]; other site
478435005486	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
478435005487	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
478435005488	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275
478435005489	putative NAD(P) binding site [chemical binding]; other site
478435005490	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
478435005491	substrate binding site [chemical binding]; other site
478435005492	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
478435005493	substrate binding site [chemical binding]; other site
478435005494	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
478435005495	metal binding site 2 [ion binding]; metal-binding site
478435005496	putative DNA binding helix; other site
478435005497	metal binding site 1 [ion binding]; metal-binding site
478435005498	dimer interface [polypeptide binding]; other site
478435005499	structural Zn2+ binding site [ion binding]; other site
478435005500	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
478435005501	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
478435005502	dimer interface [polypeptide binding]; other site
478435005503	active site
478435005504	heme binding site [chemical binding]; other site
478435005505	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
478435005506	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
478435005507	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
478435005508	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435005509	anti sigma factor interaction site; other site
478435005510	regulatory phosphorylation site [posttranslational modification]; other site
478435005511	Predicted membrane protein [Function unknown]; Region: COG1950
478435005512	putative sialic acid transporter; Region: 2A0112; TIGR00891
478435005513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435005514	putative substrate translocation pore; other site
478435005515	competence damage-inducible protein A; Provisional; Region: PRK00549
478435005516	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
478435005517	putative MPT binding site; other site
478435005518	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
478435005519	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435005520	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435005521	cyclase homology domain; Region: CHD; cd07302
478435005522	nucleotidyl binding site; other site
478435005523	metal binding site [ion binding]; metal-binding site
478435005524	dimer interface [polypeptide binding]; other site
478435005525	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
478435005526	putative ADP-ribose binding site [chemical binding]; other site
478435005527	Domain of unknown function DUF77; Region: DUF77; pfam01910
478435005528	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
478435005529	putative active site [active]
478435005530	dimerization interface [polypeptide binding]; other site
478435005531	putative tRNAtyr binding site [nucleotide binding]; other site
478435005532	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435005533	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435005534	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284
478435005535	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
478435005536	catalytic Zn binding site [ion binding]; other site
478435005537	NAD(P) binding site [chemical binding]; other site
478435005538	structural Zn binding site [ion binding]; other site
478435005539	Nitronate monooxygenase; Region: NMO; pfam03060
478435005540	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
478435005541	FMN binding site [chemical binding]; other site
478435005542	substrate binding site [chemical binding]; other site
478435005543	putative catalytic residue [active]
478435005544	Uncharacterized conserved protein [Function unknown]; Region: COG2353
478435005545	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435005546	Leucine carboxyl methyltransferase; Region: LCM; cl01306
478435005547	Leucine carboxyl methyltransferase; Region: LCM; cl01306
478435005548	Putative esterase; Region: Esterase; pfam00756
478435005549	chorismate mutase; Provisional; Region: PRK09269
478435005550	chorismate mutase, putative; Region: CM_mono2; TIGR01806
478435005551	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
478435005552	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
478435005553	hydrophobic ligand binding site; other site
478435005554	short chain dehydrogenase; Provisional; Region: PRK08267
478435005555	classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931
478435005556	putative NAD(P) binding site [chemical binding]; other site
478435005557	active site
478435005558	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
478435005559	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435005560	Cytochrome P450; Region: p450; cl12078
478435005561	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
478435005562	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
478435005563	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
478435005564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435005565	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435005566	putative substrate translocation pore; other site
478435005567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435005568	putative substrate translocation pore; other site
478435005569	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
478435005570	23S rRNA interface [nucleotide binding]; other site
478435005571	L3 interface [polypeptide binding]; other site
478435005572	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435005573	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
478435005574	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
478435005575	heme binding site [chemical binding]; other site
478435005576	ferroxidase pore; other site
478435005577	ferroxidase diiron center [ion binding]; other site
478435005578	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
478435005579	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
478435005580	Uncharacterized conserved protein [Function unknown]; Region: COG5579
478435005581	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
478435005582	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
478435005583	active site
478435005584	substrate binding site [chemical binding]; other site
478435005585	FMN binding site [chemical binding]; other site
478435005586	putative catalytic residues [active]
478435005587	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435005588	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
478435005589	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435005590	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435005591	hypothetical protein; Provisional; Region: PRK12320
478435005592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435005593	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
478435005594	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435005595	active site
478435005596	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
478435005597	CoA-transferase family III; Region: CoA_transf_3; pfam02515
478435005598	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
478435005599	CoA-transferase family III; Region: CoA_transf_3; pfam02515
478435005600	short chain dehydrogenase; Provisional; Region: PRK07825
478435005601	classical (c) SDRs; Region: SDR_c; cd05233
478435005602	NAD(P) binding site [chemical binding]; other site
478435005603	active site
478435005604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
478435005605	MOSC domain; Region: MOSC; pfam03473
478435005606	CAAX protease self-immunity; Region: Abi; pfam02517
478435005607	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
478435005608	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
478435005609	putative NAD(P) binding site [chemical binding]; other site
478435005610	putative substrate binding site [chemical binding]; other site
478435005611	catalytic Zn binding site [ion binding]; other site
478435005612	structural Zn binding site [ion binding]; other site
478435005613	Predicted membrane protein [Function unknown]; Region: COG2261
478435005614	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
478435005615	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
478435005616	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435005617	Walker A/P-loop; other site
478435005618	ATP binding site [chemical binding]; other site
478435005619	Q-loop/lid; other site
478435005620	ABC transporter signature motif; other site
478435005621	Walker B; other site
478435005622	D-loop; other site
478435005623	H-loop/switch region; other site
478435005624	TOBE domain; Region: TOBE; pfam03459
478435005625	sulfate transport protein; Provisional; Region: cysT; CHL00187
478435005626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435005627	dimer interface [polypeptide binding]; other site
478435005628	conserved gate region; other site
478435005629	putative PBP binding loops; other site
478435005630	ABC-ATPase subunit interface; other site
478435005631	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
478435005632	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
478435005633	classical (c) SDRs; Region: SDR_c; cd05233
478435005634	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
478435005635	NAD(P) binding site [chemical binding]; other site
478435005636	active site
478435005637	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
478435005638	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435005639	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435005640	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
478435005641	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435005642	UreD urease accessory protein; Region: UreD; cl00530
478435005643	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
478435005644	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
478435005645	UreF; Region: UreF; pfam01730
478435005646	urease subunit alpha; Reviewed; Region: ureC; PRK13206
478435005647	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
478435005648	subunit interactions [polypeptide binding]; other site
478435005649	active site
478435005650	flap region; other site
478435005651	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
478435005652	gamma-beta subunit interface [polypeptide binding]; other site
478435005653	alpha-beta subunit interface [polypeptide binding]; other site
478435005654	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
478435005655	alpha-gamma subunit interface [polypeptide binding]; other site
478435005656	beta-gamma subunit interface [polypeptide binding]; other site
478435005657	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
478435005658	CoenzymeA binding site [chemical binding]; other site
478435005659	subunit interaction site [polypeptide binding]; other site
478435005660	PHB binding site; other site
478435005661	Predicted transcriptional regulator [Transcription]; Region: COG3682
478435005662	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
478435005663	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
478435005664	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
478435005665	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
478435005666	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
478435005667	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435005668	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
478435005669	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
478435005670	active site
478435005671	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
478435005672	Domain of unknown function DUF21; Region: DUF21; pfam01595
478435005673	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
478435005674	Transporter associated domain; Region: CorC_HlyC; smart01091
478435005675	Domain of unknown function DUF21; Region: DUF21; pfam01595
478435005676	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
478435005677	FOG: CBS domain [General function prediction only]; Region: COG0517
478435005678	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
478435005679	putative active site [active]
478435005680	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
478435005681	active site
478435005682	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
478435005683	metal ion-dependent adhesion site (MIDAS); other site
478435005684	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
478435005685	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
478435005686	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
478435005687	haloalkane dehalogenase; Provisional; Region: PRK03204
478435005688	glycine dehydrogenase; Provisional; Region: PRK05367
478435005689	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
478435005690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435005691	tetramer interface [polypeptide binding]; other site
478435005692	catalytic residue [active]
478435005693	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
478435005694	tetramer interface [polypeptide binding]; other site
478435005695	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435005696	catalytic residue [active]
478435005697	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
478435005698	DNA binding residues [nucleotide binding]
478435005699	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
478435005700	putative dimer interface [polypeptide binding]; other site
478435005701	Bifunctional nuclease; Region: DNase-RNase; pfam02577
478435005702	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
478435005703	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
478435005704	DNA binding residues [nucleotide binding]
478435005705	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435005706	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435005707	phosphopeptide binding site; other site
478435005708	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
478435005709	lipoyl attachment site [posttranslational modification]; other site
478435005710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
478435005711	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
478435005712	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
478435005713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
478435005714	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
478435005715	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
478435005716	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
478435005717	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
478435005718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
478435005719	nucleotide binding region [chemical binding]; other site
478435005720	ATP-binding site [chemical binding]; other site
478435005721	hypothetical protein; Provisional; Region: PRK05858
478435005722	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
478435005723	PYR/PP interface [polypeptide binding]; other site
478435005724	dimer interface [polypeptide binding]; other site
478435005725	TPP binding site [chemical binding]; other site
478435005726	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
478435005727	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
478435005728	TPP-binding site; other site
478435005729	dimer interface [polypeptide binding]; other site
478435005730	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
478435005731	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
478435005732	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
478435005733	PE family; Region: PE; pfam00934
478435005734	hypothetical protein; Validated; Region: PRK07121
478435005735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435005736	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
478435005737	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
478435005738	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
478435005739	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
478435005740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435005741	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
478435005742	MgtC family; Region: MgtC; pfam02308
478435005743	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435005744	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005745	PPE family; Region: PPE; pfam00823
478435005746	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435005747	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005748	PPE family; Region: PPE; pfam00823
478435005749	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005750	PPE family; Region: PPE; pfam00823
478435005751	PE family; Region: PE; pfam00934
478435005752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435005753	Transposase; Region: HTH_Tnp_1; cl17663
478435005754	putative transposase OrfB; Reviewed; Region: PHA02517
478435005755	HTH-like domain; Region: HTH_21; pfam13276
478435005756	Integrase core domain; Region: rve; pfam00665
478435005757	Integrase core domain; Region: rve_3; pfam13683
478435005758	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435005759	PE family; Region: PE; pfam00934
478435005760	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005761	PPE family; Region: PPE; pfam00823
478435005762	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005763	PPE family; Region: PPE; pfam00823
478435005764	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005765	PPE family; Region: PPE; pfam00823
478435005766	PE-PPE domain; Region: PE-PPE; pfam08237
478435005767	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
478435005768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435005769	Walker A motif; other site
478435005770	ATP binding site [chemical binding]; other site
478435005771	Walker B motif; other site
478435005772	arginine finger; other site
478435005773	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
478435005774	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435005775	catalytic residues [active]
478435005776	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
478435005777	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
478435005778	active site
478435005779	catalytic residues [active]
478435005780	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
478435005781	EspG family; Region: ESX-1_EspG; pfam14011
478435005782	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435005783	PE family; Region: PE; pfam00934
478435005784	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005785	PPE family; Region: PPE; pfam00823
478435005786	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435005787	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005788	PPE family; Region: PPE; pfam00823
478435005789	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435005790	PE family; Region: PE; pfam00934
478435005791	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005792	PPE family; Region: PPE; pfam00823
478435005793	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435005794	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
478435005795	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435005796	Cytochrome P450; Region: p450; cl12078
478435005797	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
478435005798	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435005799	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
478435005800	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435005801	Protein of unknown function (DUF690); Region: DUF690; pfam05108
478435005802	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
478435005803	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
478435005804	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
478435005805	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435005806	Cytochrome P450; Region: p450; cl12078
478435005807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435005808	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435005809	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435005810	FAD binding domain; Region: FAD_binding_4; pfam01565
478435005811	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
478435005812	Transcriptional regulator [Transcription]; Region: IclR; COG1414
478435005813	Bacterial transcriptional regulator; Region: IclR; pfam01614
478435005814	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
478435005815	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
478435005816	FAD binding domain; Region: FAD_binding_4; pfam01565
478435005817	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
478435005818	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
478435005819	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
478435005820	metal binding site [ion binding]; metal-binding site
478435005821	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
478435005822	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
478435005823	dimer interface [polypeptide binding]; other site
478435005824	active site
478435005825	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
478435005826	substrate binding site [chemical binding]; other site
478435005827	catalytic residue [active]
478435005828	PE family; Region: PE; pfam00934
478435005829	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
478435005830	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
478435005831	putative homotetramer interface [polypeptide binding]; other site
478435005832	putative homodimer interface [polypeptide binding]; other site
478435005833	putative allosteric switch controlling residues; other site
478435005834	putative metal binding site [ion binding]; other site
478435005835	putative homodimer-homodimer interface [polypeptide binding]; other site
478435005836	Integrase core domain; Region: rve; pfam00665
478435005837	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435005838	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435005839	active site
478435005840	Uncharacterized conserved protein [Function unknown]; Region: COG0393
478435005841	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
478435005842	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435005843	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435005844	Cutinase; Region: Cutinase; pfam01083
478435005845	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435005846	Transposase; Region: HTH_Tnp_1; cl17663
478435005847	putative transposase OrfB; Reviewed; Region: PHA02517
478435005848	HTH-like domain; Region: HTH_21; pfam13276
478435005849	Integrase core domain; Region: rve; pfam00665
478435005850	Integrase core domain; Region: rve_3; pfam13683
478435005851	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
478435005852	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435005853	PPE family; Region: PPE; pfam00823
478435005854	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005855	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435005856	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
478435005857	hypothetical protein; Provisional; Region: PRK06185
478435005858	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
478435005859	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
478435005860	acyl-CoA synthetase; Provisional; Region: PRK13388
478435005861	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435005862	acyl-activating enzyme (AAE) consensus motif; other site
478435005863	AMP binding site [chemical binding]; other site
478435005864	active site
478435005865	CoA binding site [chemical binding]; other site
478435005866	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435005867	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435005868	phosphopeptide binding site; other site
478435005869	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435005870	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435005871	phosphopeptide binding site; other site
478435005872	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
478435005873	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
478435005874	Walker A/P-loop; other site
478435005875	ATP binding site [chemical binding]; other site
478435005876	Q-loop/lid; other site
478435005877	ABC transporter signature motif; other site
478435005878	Walker B; other site
478435005879	D-loop; other site
478435005880	H-loop/switch region; other site
478435005881	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
478435005882	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435005883	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435005884	active site
478435005885	ATP binding site [chemical binding]; other site
478435005886	substrate binding site [chemical binding]; other site
478435005887	activation loop (A-loop); other site
478435005888	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
478435005889	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
478435005890	active site
478435005891	metal binding site [ion binding]; metal-binding site
478435005892	nudix motif; other site
478435005893	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
478435005894	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435005895	active site
478435005896	ATP binding site [chemical binding]; other site
478435005897	substrate binding site [chemical binding]; other site
478435005898	activation loop (A-loop); other site
478435005899	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
478435005900	Thioredoxin; Region: Thioredoxin_4; cl17273
478435005901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742
478435005902	putative active site [active]
478435005903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
478435005904	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
478435005905	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
478435005906	Sulfate transporter family; Region: Sulfate_transp; pfam00916
478435005907	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
478435005908	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
478435005909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435005910	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
478435005911	putative substrate translocation pore; other site
478435005912	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
478435005913	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435005914	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
478435005915	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
478435005916	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
478435005917	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
478435005918	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
478435005919	gating phenylalanine in ion channel; other site
478435005920	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
478435005921	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
478435005922	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
478435005923	putative catalytic residue [active]
478435005924	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
478435005925	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
478435005926	NAD(P) binding site [chemical binding]; other site
478435005927	catalytic residues [active]
478435005928	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435005929	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435005930	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435005931	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435005932	TIGR03086 family protein; Region: TIGR03086
478435005933	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435005934	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435005935	FAD binding domain; Region: FAD_binding_4; pfam01565
478435005936	Berberine and berberine like; Region: BBE; pfam08031
478435005937	Predicted transcriptional regulators [Transcription]; Region: COG1733
478435005938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435005939	dimerization interface [polypeptide binding]; other site
478435005940	putative DNA binding site [nucleotide binding]; other site
478435005941	putative Zn2+ binding site [ion binding]; other site
478435005942	Predicted transcriptional regulators [Transcription]; Region: COG1733
478435005943	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435005944	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435005945	biotin carboxylase-like protein; Validated; Region: PRK06524
478435005946	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435005947	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
478435005948	putative active site [active]
478435005949	homotetrameric interface [polypeptide binding]; other site
478435005950	metal binding site [ion binding]; metal-binding site
478435005951	Transcriptional regulator [Transcription]; Region: IclR; COG1414
478435005952	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
478435005953	putative switch regulator; other site
478435005954	non-specific DNA interactions [nucleotide binding]; other site
478435005955	DNA binding site [nucleotide binding]
478435005956	sequence specific DNA binding site [nucleotide binding]; other site
478435005957	putative cAMP binding site [chemical binding]; other site
478435005958	Bacterial transcriptional regulator; Region: IclR; pfam01614
478435005959	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
478435005960	Cupin domain; Region: Cupin_2; cl17218
478435005961	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
478435005962	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
478435005963	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
478435005964	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
478435005965	short chain dehydrogenase; Provisional; Region: PRK07060
478435005966	classical (c) SDRs; Region: SDR_c; cd05233
478435005967	NAD(P) binding site [chemical binding]; other site
478435005968	active site
478435005969	GTP-binding protein Der; Reviewed; Region: PRK03003
478435005970	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
478435005971	GTP/Mg2+ binding site [chemical binding]; other site
478435005972	Switch I region; other site
478435005973	G2 box; other site
478435005974	Switch II region; other site
478435005975	G3 box; other site
478435005976	G4 box; other site
478435005977	G5 box; other site
478435005978	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
478435005979	G1 box; other site
478435005980	GTP/Mg2+ binding site [chemical binding]; other site
478435005981	Switch I region; other site
478435005982	G2 box; other site
478435005983	G3 box; other site
478435005984	Switch II region; other site
478435005985	G4 box; other site
478435005986	G5 box; other site
478435005987	cytidylate kinase; Provisional; Region: cmk; PRK00023
478435005988	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
478435005989	CMP-binding site; other site
478435005990	The sites determining sugar specificity; other site
478435005991	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
478435005992	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
478435005993	RNA binding surface [nucleotide binding]; other site
478435005994	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
478435005995	active site
478435005996	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
478435005997	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
478435005998	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435005999	P-loop; other site
478435006000	Magnesium ion binding site [ion binding]; other site
478435006001	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435006002	Magnesium ion binding site [ion binding]; other site
478435006003	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
478435006004	Sulfate transporter family; Region: Sulfate_transp; pfam00916
478435006005	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
478435006006	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435006007	PPE family; Region: PPE; pfam00823
478435006008	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435006009	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435006010	PPE family; Region: PPE; pfam00823
478435006011	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435006012	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
478435006013	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
478435006014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006015	S-adenosylmethionine binding site [chemical binding]; other site
478435006016	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435006017	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435006018	active site
478435006019	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
478435006020	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435006021	active site
478435006022	DNA binding site [nucleotide binding]
478435006023	Int/Topo IB signature motif; other site
478435006024	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
478435006025	dimer interface [polypeptide binding]; other site
478435006026	ADP-ribose binding site [chemical binding]; other site
478435006027	active site
478435006028	nudix motif; other site
478435006029	metal binding site [ion binding]; metal-binding site
478435006030	CTP synthetase; Validated; Region: pyrG; PRK05380
478435006031	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
478435006032	Catalytic site [active]
478435006033	active site
478435006034	UTP binding site [chemical binding]; other site
478435006035	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
478435006036	active site
478435006037	putative oxyanion hole; other site
478435006038	catalytic triad [active]
478435006039	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
478435006040	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
478435006041	Thiamine pyrophosphokinase; Region: TPK; cl08415
478435006042	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
478435006043	DNA repair protein RecN; Region: recN; TIGR00634
478435006044	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
478435006045	Walker A/P-loop; other site
478435006046	ATP binding site [chemical binding]; other site
478435006047	Q-loop/lid; other site
478435006048	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
478435006049	ABC transporter signature motif; other site
478435006050	Walker B; other site
478435006051	D-loop; other site
478435006052	H-loop/switch region; other site
478435006053	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
478435006054	ATP-NAD kinase; Region: NAD_kinase; pfam01513
478435006055	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
478435006056	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
478435006057	RNA binding surface [nucleotide binding]; other site
478435006058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006059	S-adenosylmethionine binding site [chemical binding]; other site
478435006060	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
478435006061	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
478435006062	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
478435006063	Tetratrico peptide repeat; Region: TPR_5; pfam12688
478435006064	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435006065	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
478435006066	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
478435006067	active site
478435006068	HIGH motif; other site
478435006069	dimer interface [polypeptide binding]; other site
478435006070	KMSKS motif; other site
478435006071	S4 RNA-binding domain; Region: S4; smart00363
478435006072	RNA binding surface [nucleotide binding]; other site
478435006073	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
478435006074	active site
478435006075	DNA binding site [nucleotide binding]
478435006076	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
478435006077	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
478435006078	Walker A/P-loop; other site
478435006079	ATP binding site [chemical binding]; other site
478435006080	Q-loop/lid; other site
478435006081	ABC transporter signature motif; other site
478435006082	Walker B; other site
478435006083	D-loop; other site
478435006084	H-loop/switch region; other site
478435006085	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
478435006086	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
478435006087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435006088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435006089	acyl-CoA synthetase; Validated; Region: PRK07868
478435006090	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
478435006091	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435006092	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435006093	acyl-activating enzyme (AAE) consensus motif; other site
478435006094	AMP binding site [chemical binding]; other site
478435006095	active site
478435006096	CoA binding site [chemical binding]; other site
478435006097	DivIVA protein; Region: DivIVA; pfam05103
478435006098	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
478435006099	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
478435006100	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435006101	FeS/SAM binding site; other site
478435006102	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
478435006103	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
478435006104	substrate binding pocket [chemical binding]; other site
478435006105	membrane-bound complex binding site; other site
478435006106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435006107	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435006108	active site
478435006109	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
478435006110	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435006111	catalytic residues [active]
478435006112	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
478435006113	putative catalytic residues [active]
478435006114	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435006115	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435006116	ligand binding site [chemical binding]; other site
478435006117	flexible hinge region; other site
478435006118	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
478435006119	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435006120	dimerization interface [polypeptide binding]; other site
478435006121	putative DNA binding site [nucleotide binding]; other site
478435006122	putative Zn2+ binding site [ion binding]; other site
478435006123	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
478435006124	active site residue [active]
478435006125	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
478435006126	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
478435006127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435006128	putative substrate translocation pore; other site
478435006129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
478435006130	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
478435006131	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435006132	ABC transporter; Region: ABC_tran_2; pfam12848
478435006133	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435006134	Cytochrome P450; Region: p450; cl12078
478435006135	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435006136	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
478435006137	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
478435006138	malonyl-CoA binding site [chemical binding]; other site
478435006139	dimer interface [polypeptide binding]; other site
478435006140	active site
478435006141	product binding site; other site
478435006142	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
478435006143	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435006144	active site
478435006145	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435006146	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435006147	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435006148	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
478435006149	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
478435006150	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435006151	putative NADP binding site [chemical binding]; other site
478435006152	active site
478435006153	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435006154	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435006155	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435006156	active site
478435006157	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435006158	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435006159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006160	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435006161	Enoylreductase; Region: PKS_ER; smart00829
478435006162	NAD(P) binding site [chemical binding]; other site
478435006163	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435006164	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435006165	active site
478435006166	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435006167	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435006168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006169	Enoylreductase; Region: PKS_ER; smart00829
478435006170	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435006171	NAD(P) binding site [chemical binding]; other site
478435006172	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
478435006173	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435006174	putative NADP binding site [chemical binding]; other site
478435006175	active site
478435006176	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435006177	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
478435006178	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
478435006179	malonyl-CoA binding site [chemical binding]; other site
478435006180	dimer interface [polypeptide binding]; other site
478435006181	active site
478435006182	product binding site; other site
478435006183	argininosuccinate lyase; Provisional; Region: PRK00855
478435006184	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
478435006185	active sites [active]
478435006186	tetramer interface [polypeptide binding]; other site
478435006187	argininosuccinate synthase; Provisional; Region: PRK13820
478435006188	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
478435006189	ANP binding site [chemical binding]; other site
478435006190	Substrate Binding Site II [chemical binding]; other site
478435006191	Substrate Binding Site I [chemical binding]; other site
478435006192	arginine repressor; Provisional; Region: PRK03341
478435006193	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
478435006194	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
478435006195	ornithine carbamoyltransferase; Provisional; Region: PRK00779
478435006196	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
478435006197	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
478435006198	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
478435006199	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
478435006200	inhibitor-cofactor binding pocket; inhibition site
478435006201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006202	catalytic residue [active]
478435006203	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
478435006204	feedback inhibition sensing region; other site
478435006205	homohexameric interface [polypeptide binding]; other site
478435006206	nucleotide binding site [chemical binding]; other site
478435006207	N-acetyl-L-glutamate binding site [chemical binding]; other site
478435006208	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
478435006209	heterotetramer interface [polypeptide binding]; other site
478435006210	active site pocket [active]
478435006211	cleavage site
478435006212	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
478435006213	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
478435006214	PE family; Region: PE; pfam00934
478435006215	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
478435006216	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
478435006217	putative tRNA-binding site [nucleotide binding]; other site
478435006218	B3/4 domain; Region: B3_4; pfam03483
478435006219	tRNA synthetase B5 domain; Region: B5; smart00874
478435006220	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
478435006221	dimer interface [polypeptide binding]; other site
478435006222	motif 1; other site
478435006223	motif 3; other site
478435006224	motif 2; other site
478435006225	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
478435006226	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
478435006227	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
478435006228	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
478435006229	dimer interface [polypeptide binding]; other site
478435006230	motif 1; other site
478435006231	active site
478435006232	motif 2; other site
478435006233	motif 3; other site
478435006234	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435006235	cyclase homology domain; Region: CHD; cd07302
478435006236	nucleotidyl binding site; other site
478435006237	metal binding site [ion binding]; metal-binding site
478435006238	dimer interface [polypeptide binding]; other site
478435006239	PE family; Region: PE; pfam00934
478435006240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
478435006241	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
478435006242	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
478435006243	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
478435006244	23S rRNA binding site [nucleotide binding]; other site
478435006245	L21 binding site [polypeptide binding]; other site
478435006246	L13 binding site [polypeptide binding]; other site
478435006247	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
478435006248	translation initiation factor IF-3; Region: infC; TIGR00168
478435006249	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
478435006250	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
478435006251	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
478435006252	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
478435006253	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
478435006254	dimer interface [polypeptide binding]; other site
478435006255	putative anticodon binding site; other site
478435006256	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
478435006257	motif 1; other site
478435006258	dimer interface [polypeptide binding]; other site
478435006259	active site
478435006260	motif 2; other site
478435006261	motif 3; other site
478435006262	Predicted esterase [General function prediction only]; Region: COG0627
478435006263	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
478435006264	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
478435006265	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
478435006266	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
478435006267	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
478435006268	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
478435006269	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435006270	Ligand Binding Site [chemical binding]; other site
478435006271	Predicted membrane protein [Function unknown]; Region: COG5305
478435006272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435006273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435006274	putative substrate translocation pore; other site
478435006275	excinuclease ABC subunit B; Provisional; Region: PRK05298
478435006276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435006277	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435006278	nucleotide binding region [chemical binding]; other site
478435006279	ATP-binding site [chemical binding]; other site
478435006280	Ultra-violet resistance protein B; Region: UvrB; pfam12344
478435006281	UvrB/uvrC motif; Region: UVR; pfam02151
478435006282	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
478435006283	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
478435006284	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
478435006285	CoA-binding site [chemical binding]; other site
478435006286	ATP-binding [chemical binding]; other site
478435006287	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
478435006288	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
478435006289	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
478435006290	RNA binding site [nucleotide binding]; other site
478435006291	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
478435006292	RNA binding site [nucleotide binding]; other site
478435006293	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
478435006294	RNA binding site [nucleotide binding]; other site
478435006295	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
478435006296	RNA binding site [nucleotide binding]; other site
478435006297	DNA polymerase I; Provisional; Region: PRK05755
478435006298	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
478435006299	active site
478435006300	metal binding site 1 [ion binding]; metal-binding site
478435006301	putative 5' ssDNA interaction site; other site
478435006302	metal binding site 3; metal-binding site
478435006303	metal binding site 2 [ion binding]; metal-binding site
478435006304	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
478435006305	putative DNA binding site [nucleotide binding]; other site
478435006306	putative metal binding site [ion binding]; other site
478435006307	3'-5' exonuclease; Region: 35EXOc; smart00474
478435006308	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
478435006309	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
478435006310	active site
478435006311	DNA binding site [nucleotide binding]
478435006312	catalytic site [active]
478435006313	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
478435006314	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
478435006315	DUF35 OB-fold domain; Region: DUF35; pfam01796
478435006316	lipid-transfer protein; Provisional; Region: PRK06059
478435006317	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435006318	active site
478435006319	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
478435006320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435006321	active site
478435006322	phosphorylation site [posttranslational modification]
478435006323	intermolecular recognition site; other site
478435006324	dimerization interface [polypeptide binding]; other site
478435006325	ANTAR domain; Region: ANTAR; pfam03861
478435006326	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
478435006327	cyclase homology domain; Region: CHD; cd07302
478435006328	nucleotidyl binding site; other site
478435006329	metal binding site [ion binding]; metal-binding site
478435006330	dimer interface [polypeptide binding]; other site
478435006331	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
478435006332	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
478435006333	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
478435006334	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
478435006335	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
478435006336	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
478435006337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435006338	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
478435006339	Walker A/P-loop; other site
478435006340	Walker A/P-loop; other site
478435006341	ATP binding site [chemical binding]; other site
478435006342	ATP binding site [chemical binding]; other site
478435006343	Q-loop/lid; other site
478435006344	Uncharacterized conserved protein [Function unknown]; Region: COG2898
478435006345	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
478435006346	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
478435006347	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
478435006348	active site
478435006349	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
478435006350	catalytic triad [active]
478435006351	dimer interface [polypeptide binding]; other site
478435006352	pyruvate kinase; Provisional; Region: PRK06247
478435006353	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
478435006354	domain interfaces; other site
478435006355	active site
478435006356	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
478435006357	TM2 domain; Region: TM2; pfam05154
478435006358	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
478435006359	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
478435006360	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
478435006361	substrate binding site [chemical binding]; other site
478435006362	active site
478435006363	catalytic residues [active]
478435006364	heterodimer interface [polypeptide binding]; other site
478435006365	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
478435006366	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
478435006367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006368	catalytic residue [active]
478435006369	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
478435006370	active site
478435006371	ribulose/triose binding site [chemical binding]; other site
478435006372	phosphate binding site [ion binding]; other site
478435006373	substrate (anthranilate) binding pocket [chemical binding]; other site
478435006374	product (indole) binding pocket [chemical binding]; other site
478435006375	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
478435006376	anthranilate synthase component I; Provisional; Region: PRK13571
478435006377	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
478435006378	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
478435006379	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
478435006380	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
478435006381	catalytic triad [active]
478435006382	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
478435006383	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
478435006384	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
478435006385	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
478435006386	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
478435006387	substrate binding site [chemical binding]; other site
478435006388	glutamase interaction surface [polypeptide binding]; other site
478435006389	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
478435006390	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
478435006391	active site
478435006392	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
478435006393	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
478435006394	catalytic residues [active]
478435006395	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
478435006396	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
478435006397	putative active site [active]
478435006398	oxyanion strand; other site
478435006399	catalytic triad [active]
478435006400	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
478435006401	4-fold oligomerization interface [polypeptide binding]; other site
478435006402	putative active site pocket [active]
478435006403	metal binding residues [ion binding]; metal-binding site
478435006404	3-fold/trimer interface [polypeptide binding]; other site
478435006405	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
478435006406	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435006407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006408	homodimer interface [polypeptide binding]; other site
478435006409	catalytic residue [active]
478435006410	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
478435006411	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
478435006412	NAD binding site [chemical binding]; other site
478435006413	dimerization interface [polypeptide binding]; other site
478435006414	product binding site; other site
478435006415	substrate binding site [chemical binding]; other site
478435006416	zinc binding site [ion binding]; other site
478435006417	catalytic residues [active]
478435006418	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
478435006419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006420	S-adenosylmethionine binding site [chemical binding]; other site
478435006421	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
478435006422	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
478435006423	dimerization interface [polypeptide binding]; other site
478435006424	active site
478435006425	L-aspartate oxidase; Provisional; Region: PRK07804
478435006426	L-aspartate oxidase; Provisional; Region: PRK06175
478435006427	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
478435006428	quinolinate synthetase; Provisional; Region: PRK09375
478435006429	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
478435006430	nudix motif; other site
478435006431	Secretory lipase; Region: LIP; pfam03583
478435006432	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
478435006433	biotin synthase; Validated; Region: PRK06256
478435006434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435006435	FeS/SAM binding site; other site
478435006436	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
478435006437	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435006438	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435006439	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435006440	active site
478435006441	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
478435006442	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
478435006443	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
478435006444	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
478435006445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435006446	catalytic residue [active]
478435006447	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
478435006448	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
478435006449	inhibitor-cofactor binding pocket; inhibition site
478435006450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006451	catalytic residue [active]
478435006452	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
478435006453	NlpC/P60 family; Region: NLPC_P60; pfam00877
478435006454	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
478435006455	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
478435006456	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
478435006457	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
478435006458	active site
478435006459	catalytic site [active]
478435006460	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
478435006461	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
478435006462	active site
478435006463	catalytic site [active]
478435006464	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
478435006465	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
478435006466	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
478435006467	catalytic site [active]
478435006468	active site
478435006469	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
478435006470	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
478435006471	putative active site [active]
478435006472	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
478435006473	threonine dehydratase; Validated; Region: PRK08639
478435006474	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
478435006475	tetramer interface [polypeptide binding]; other site
478435006476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006477	catalytic residue [active]
478435006478	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
478435006479	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435006480	MMPL family; Region: MMPL; pfam03176
478435006481	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435006482	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435006483	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
478435006484	Iron-sulfur protein interface; other site
478435006485	proximal quinone binding site [chemical binding]; other site
478435006486	C-subunit interface; other site
478435006487	distal quinone binding site; other site
478435006488	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
478435006489	D-subunit interface [polypeptide binding]; other site
478435006490	Iron-sulfur protein interface; other site
478435006491	proximal quinone binding site [chemical binding]; other site
478435006492	distal quinone binding site [chemical binding]; other site
478435006493	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
478435006494	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
478435006495	fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176
478435006496	L-aspartate oxidase; Provisional; Region: PRK06175
478435006497	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
478435006498	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
478435006499	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
478435006500	putative acyl-acceptor binding pocket; other site
478435006501	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
478435006502	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
478435006503	acyl-activating enzyme (AAE) consensus motif; other site
478435006504	putative AMP binding site [chemical binding]; other site
478435006505	putative active site [active]
478435006506	putative CoA binding site [chemical binding]; other site
478435006507	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435006508	PPE family; Region: PPE; pfam00823
478435006509	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435006510	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435006511	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
478435006512	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
478435006513	active site
478435006514	PHP Thumb interface [polypeptide binding]; other site
478435006515	metal binding site [ion binding]; metal-binding site
478435006516	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
478435006517	generic binding surface II; other site
478435006518	generic binding surface I; other site
478435006519	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
478435006520	hydrophobic ligand binding site; other site
478435006521	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
478435006522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006523	NAD(P) binding site [chemical binding]; other site
478435006524	active site
478435006525	short chain dehydrogenase; Provisional; Region: PRK05866
478435006526	classical (c) SDRs; Region: SDR_c; cd05233
478435006527	NAD(P) binding site [chemical binding]; other site
478435006528	active site
478435006529	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
478435006530	apolar tunnel; other site
478435006531	heme binding site [chemical binding]; other site
478435006532	dimerization interface [polypeptide binding]; other site
478435006533	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
478435006534	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
478435006535	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
478435006536	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
478435006537	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
478435006538	active site
478435006539	lipoprotein signal peptidase; Provisional; Region: PRK14764
478435006540	lipoprotein signal peptidase; Provisional; Region: PRK14787
478435006541	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
478435006542	active site
478435006543	homodimer interface [polypeptide binding]; other site
478435006544	homotetramer interface [polypeptide binding]; other site
478435006545	DNA polymerase IV; Provisional; Region: PRK03348
478435006546	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
478435006547	active site
478435006548	DNA binding site [nucleotide binding]
478435006549	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
478435006550	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
478435006551	HIGH motif; other site
478435006552	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
478435006553	active site
478435006554	KMSKS motif; other site
478435006555	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
478435006556	tRNA binding surface [nucleotide binding]; other site
478435006557	anticodon binding site; other site
478435006558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435006559	Nitronate monooxygenase; Region: NMO; pfam03060
478435006560	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
478435006561	FMN binding site [chemical binding]; other site
478435006562	substrate binding site [chemical binding]; other site
478435006563	putative catalytic residue [active]
478435006564	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
478435006565	CoenzymeA binding site [chemical binding]; other site
478435006566	subunit interaction site [polypeptide binding]; other site
478435006567	PHB binding site; other site
478435006568	Uncharacterized conserved protein [Function unknown]; Region: COG2128
478435006569	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
478435006570	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
478435006571	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
478435006572	NAD(P) binding site [chemical binding]; other site
478435006573	acyl-CoA synthetase; Validated; Region: PRK05850
478435006574	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435006575	acyl-activating enzyme (AAE) consensus motif; other site
478435006576	active site
478435006577	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435006578	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435006579	active site
478435006580	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
478435006581	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435006582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006583	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435006584	Enoylreductase; Region: PKS_ER; smart00829
478435006585	NAD(P) binding site [chemical binding]; other site
478435006586	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435006587	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435006588	putative NADP binding site [chemical binding]; other site
478435006589	active site
478435006590	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435006591	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
478435006592	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
478435006593	homodimer interface [polypeptide binding]; other site
478435006594	active site
478435006595	TDP-binding site; other site
478435006596	acceptor substrate-binding pocket; other site
478435006597	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
478435006598	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
478435006599	Probable Catalytic site; other site
478435006600	metal-binding site
478435006601	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
478435006602	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
478435006603	homodimer interface [polypeptide binding]; other site
478435006604	active site
478435006605	TDP-binding site; other site
478435006606	acceptor substrate-binding pocket; other site
478435006607	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435006608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006609	S-adenosylmethionine binding site [chemical binding]; other site
478435006610	Transport protein; Region: actII; TIGR00833
478435006611	acyl-CoA synthetase; Validated; Region: PRK05850
478435006612	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435006613	acyl-activating enzyme (AAE) consensus motif; other site
478435006614	active site
478435006615	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
478435006616	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
478435006617	active site
478435006618	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
478435006619	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
478435006620	active site
478435006621	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
478435006622	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
478435006623	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
478435006624	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
478435006625	active site
478435006626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006627	S-adenosylmethionine binding site [chemical binding]; other site
478435006628	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
478435006629	metal-binding site
478435006630	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
478435006631	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
478435006632	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
478435006633	NADP binding site [chemical binding]; other site
478435006634	active site
478435006635	putative substrate binding site [chemical binding]; other site
478435006636	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
478435006637	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
478435006638	NADP-binding site; other site
478435006639	homotetramer interface [polypeptide binding]; other site
478435006640	substrate binding site [chemical binding]; other site
478435006641	homodimer interface [polypeptide binding]; other site
478435006642	active site
478435006643	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435006644	Methyltransferase domain; Region: Methyltransf_12; pfam08242
478435006645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435006647	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
478435006648	WbqC-like protein family; Region: WbqC; pfam08889
478435006649	Methyltransferase domain; Region: Methyltransf_12; pfam08242
478435006650	S-adenosylmethionine binding site [chemical binding]; other site
478435006651	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
478435006652	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
478435006653	putative trimer interface [polypeptide binding]; other site
478435006654	putative CoA binding site [chemical binding]; other site
478435006655	potential frameshift: common BLAST hit: gi|378771270|ref|YP_005171003.1| TDP-4-oxo-6-deoxy-D-glucose transaminase
478435006656	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
478435006657	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
478435006658	inhibitor-cofactor binding pocket; inhibition site
478435006659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435006660	catalytic residue [active]
478435006661	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435006662	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
478435006663	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
478435006664	active site
478435006665	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
478435006666	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
478435006667	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
478435006668	Ligand binding site; other site
478435006669	Putative Catalytic site; other site
478435006670	DXD motif; other site
478435006671	Uncharacterized conserved protein [Function unknown]; Region: COG3360
478435006672	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435006673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006674	S-adenosylmethionine binding site [chemical binding]; other site
478435006675	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435006676	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435006677	membrane ATPase/protein kinase; Provisional; Region: PRK09435
478435006678	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
478435006679	Walker A; other site
478435006680	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435006681	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
478435006682	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
478435006683	active site
478435006684	substrate binding site [chemical binding]; other site
478435006685	coenzyme B12 binding site [chemical binding]; other site
478435006686	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
478435006687	B12 binding site [chemical binding]; other site
478435006688	cobalt ligand [ion binding]; other site
478435006689	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
478435006690	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
478435006691	heterodimer interface [polypeptide binding]; other site
478435006692	substrate interaction site [chemical binding]; other site
478435006693	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
478435006694	Uncharacterized conserved protein [Function unknown]; Region: COG0398
478435006695	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
478435006696	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
478435006697	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
478435006698	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
478435006699	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
478435006700	ferrochelatase; Reviewed; Region: hemH; PRK00035
478435006701	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
478435006702	C-terminal domain interface [polypeptide binding]; other site
478435006703	active site
478435006704	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
478435006705	active site
478435006706	N-terminal domain interface [polypeptide binding]; other site
478435006707	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
478435006708	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
478435006709	NAD binding site [chemical binding]; other site
478435006710	homotetramer interface [polypeptide binding]; other site
478435006711	homodimer interface [polypeptide binding]; other site
478435006712	substrate binding site [chemical binding]; other site
478435006713	active site
478435006714	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
478435006715	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
478435006716	NAD(P) binding site [chemical binding]; other site
478435006717	homotetramer interface [polypeptide binding]; other site
478435006718	homodimer interface [polypeptide binding]; other site
478435006719	active site
478435006720	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
478435006721	hypothetical protein; Provisional; Region: PRK13685
478435006722	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
478435006723	metal ion-dependent adhesion site (MIDAS); other site
478435006724	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
478435006725	Protein of unknown function DUF58; Region: DUF58; pfam01882
478435006726	MoxR-like ATPases [General function prediction only]; Region: COG0714
478435006727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435006728	Walker A motif; other site
478435006729	ATP binding site [chemical binding]; other site
478435006730	Walker B motif; other site
478435006731	arginine finger; other site
478435006732	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
478435006733	NlpC/P60 family; Region: NLPC_P60; pfam00877
478435006734	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
478435006735	NlpC/P60 family; Region: NLPC_P60; pfam00877
478435006736	aconitate hydratase; Validated; Region: PRK09277
478435006737	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
478435006738	substrate binding site [chemical binding]; other site
478435006739	ligand binding site [chemical binding]; other site
478435006740	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
478435006741	substrate binding site [chemical binding]; other site
478435006742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435006743	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435006744	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
478435006745	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435006746	Walker A/P-loop; other site
478435006747	ATP binding site [chemical binding]; other site
478435006748	Q-loop/lid; other site
478435006749	ABC transporter signature motif; other site
478435006750	Walker B; other site
478435006751	D-loop; other site
478435006752	H-loop/switch region; other site
478435006753	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
478435006754	enoyl-CoA hydratase; Provisional; Region: PRK05864
478435006755	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435006756	substrate binding site [chemical binding]; other site
478435006757	oxyanion hole (OAH) forming residues; other site
478435006758	trimer interface [polypeptide binding]; other site
478435006759	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
478435006760	catalytic residues [active]
478435006761	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
478435006762	catalytic residues [active]
478435006763	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
478435006764	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435006765	PE family; Region: PE; pfam00934
478435006766	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
478435006767	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
478435006768	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435006769	active site
478435006770	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
478435006771	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
478435006772	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
478435006773	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
478435006774	trimerization site [polypeptide binding]; other site
478435006775	active site
478435006776	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
478435006777	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
478435006778	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435006779	catalytic residue [active]
478435006780	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
478435006781	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
478435006782	Walker A/P-loop; other site
478435006783	ATP binding site [chemical binding]; other site
478435006784	Q-loop/lid; other site
478435006785	ABC transporter signature motif; other site
478435006786	Walker B; other site
478435006787	D-loop; other site
478435006788	H-loop/switch region; other site
478435006789	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
478435006790	FeS assembly protein SufD; Region: sufD; TIGR01981
478435006791	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
478435006792	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
478435006793	protein-splicing catalytic site; other site
478435006794	thioester formation/cholesterol transfer; other site
478435006795	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
478435006796	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
478435006797	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
478435006798	Predicted transcriptional regulator [Transcription]; Region: COG2345
478435006799	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435006800	putative DNA binding site [nucleotide binding]; other site
478435006801	putative Zn2+ binding site [ion binding]; other site
478435006802	Transcriptional regulator PadR-like family; Region: PadR; cl17335
478435006803	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
478435006804	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
478435006805	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
478435006806	Walker A/P-loop; other site
478435006807	ATP binding site [chemical binding]; other site
478435006808	Q-loop/lid; other site
478435006809	ABC transporter signature motif; other site
478435006810	Walker B; other site
478435006811	D-loop; other site
478435006812	H-loop/switch region; other site
478435006813	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
478435006814	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
478435006815	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
478435006816	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
478435006817	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
478435006818	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
478435006819	NADP binding site [chemical binding]; other site
478435006820	dimer interface [polypeptide binding]; other site
478435006821	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435006822	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
478435006823	PE family; Region: PE; pfam00934
478435006824	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
478435006825	UbiA prenyltransferase family; Region: UbiA; pfam01040
478435006826	PE family; Region: PE; pfam00934
478435006827	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
478435006828	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
478435006829	TPP-binding site [chemical binding]; other site
478435006830	dimer interface [polypeptide binding]; other site
478435006831	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
478435006832	PYR/PP interface [polypeptide binding]; other site
478435006833	dimer interface [polypeptide binding]; other site
478435006834	TPP binding site [chemical binding]; other site
478435006835	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
478435006836	putative active site [active]
478435006837	transaldolase; Provisional; Region: PRK03903
478435006838	catalytic residue [active]
478435006839	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
478435006840	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
478435006841	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
478435006842	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
478435006843	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
478435006844	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
478435006845	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
478435006846	putative active site [active]
478435006847	Proteins of 100 residues with WXG; Region: WXG100; cl02005
478435006848	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
478435006849	hydrophobic ligand binding site; other site
478435006850	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
478435006851	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
478435006852	molybdopterin cofactor binding site [chemical binding]; other site
478435006853	substrate binding site [chemical binding]; other site
478435006854	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
478435006855	molybdopterin cofactor binding site; other site
478435006856	PE family; Region: PE; pfam00934
478435006857	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
478435006858	SnoaL-like domain; Region: SnoaL_2; pfam12680
478435006859	triosephosphate isomerase; Provisional; Region: PRK14567
478435006860	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
478435006861	substrate binding site [chemical binding]; other site
478435006862	dimer interface [polypeptide binding]; other site
478435006863	catalytic triad [active]
478435006864	Phosphoglycerate kinase; Region: PGK; pfam00162
478435006865	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
478435006866	substrate binding site [chemical binding]; other site
478435006867	hinge regions; other site
478435006868	ADP binding site [chemical binding]; other site
478435006869	catalytic site [active]
478435006870	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
478435006871	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
478435006872	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
478435006873	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
478435006874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
478435006875	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
478435006876	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
478435006877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435006878	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
478435006879	PE family; Region: PE; pfam00934
478435006880	PE-PPE domain; Region: PE-PPE; pfam08237
478435006881	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435006882	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
478435006883	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435006884	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
478435006885	putative acyl-acceptor binding pocket; other site
478435006886	acyl-CoA synthetase; Provisional; Region: PRK13382
478435006887	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
478435006888	acyl-activating enzyme (AAE) consensus motif; other site
478435006889	putative AMP binding site [chemical binding]; other site
478435006890	putative active site [active]
478435006891	putative CoA binding site [chemical binding]; other site
478435006892	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435006893	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435006894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
478435006895	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
478435006896	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
478435006897	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
478435006898	phosphate binding site [ion binding]; other site
478435006899	putative substrate binding pocket [chemical binding]; other site
478435006900	dimer interface [polypeptide binding]; other site
478435006901	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
478435006902	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
478435006903	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
478435006904	GIY-YIG motif/motif A; other site
478435006905	active site
478435006906	catalytic site [active]
478435006907	putative DNA binding site [nucleotide binding]; other site
478435006908	metal binding site [ion binding]; metal-binding site
478435006909	UvrB/uvrC motif; Region: UVR; pfam02151
478435006910	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
478435006911	Helix-hairpin-helix motif; Region: HHH; pfam00633
478435006912	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
478435006913	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
478435006914	putative sugar binding sites [chemical binding]; other site
478435006915	Q-X-W motif; other site
478435006916	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435006917	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
478435006918	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
478435006919	homopentamer interface [polypeptide binding]; other site
478435006920	active site
478435006921	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
478435006922	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
478435006923	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
478435006924	dimerization interface [polypeptide binding]; other site
478435006925	active site
478435006926	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
478435006927	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
478435006928	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
478435006929	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
478435006930	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
478435006931	Lumazine binding domain; Region: Lum_binding; pfam00677
478435006932	Lumazine binding domain; Region: Lum_binding; pfam00677
478435006933	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
478435006934	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435006935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435006936	putative substrate translocation pore; other site
478435006937	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
478435006938	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
478435006939	catalytic motif [active]
478435006940	Zn binding site [ion binding]; other site
478435006941	RibD C-terminal domain; Region: RibD_C; pfam01872
478435006942	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
478435006943	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
478435006944	substrate binding site [chemical binding]; other site
478435006945	hexamer interface [polypeptide binding]; other site
478435006946	metal binding site [ion binding]; metal-binding site
478435006947	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
478435006948	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
478435006949	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
478435006950	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
478435006951	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
478435006952	putative active site [active]
478435006953	substrate binding site [chemical binding]; other site
478435006954	putative cosubstrate binding site; other site
478435006955	catalytic site [active]
478435006956	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
478435006957	substrate binding site [chemical binding]; other site
478435006958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006959	S-adenosylmethionine binding site [chemical binding]; other site
478435006960	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435006961	MarR family; Region: MarR; pfam01047
478435006962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435006963	S-adenosylmethionine binding site [chemical binding]; other site
478435006964	primosome assembly protein PriA; Provisional; Region: PRK14873
478435006965	Predicted membrane protein [Function unknown]; Region: COG3714
478435006966	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435006967	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435006968	substrate binding pocket [chemical binding]; other site
478435006969	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435006970	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435006971	substrate binding pocket [chemical binding]; other site
478435006972	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435006973	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
478435006974	oligomeric interface; other site
478435006975	putative active site [active]
478435006976	homodimer interface [polypeptide binding]; other site
478435006977	PE family; Region: PE; pfam00934
478435006978	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
478435006979	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
478435006980	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
478435006981	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435006982	Cytochrome P450; Region: p450; cl12078
478435006983	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435006984	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435006985	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
478435006986	S-adenosylmethionine synthetase; Validated; Region: PRK05250
478435006987	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
478435006988	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
478435006989	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
478435006990	Flavoprotein; Region: Flavoprotein; pfam02441
478435006991	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
478435006992	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
478435006993	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
478435006994	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
478435006995	catalytic site [active]
478435006996	G-X2-G-X-G-K; other site
478435006997	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435006998	PPE family; Region: PPE; pfam00823
478435006999	PE family; Region: PE; pfam00934
478435007000	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
478435007001	active site
478435007002	dimer interface [polypeptide binding]; other site
478435007003	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
478435007004	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435007005	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435007006	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
478435007007	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435007008	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435007009	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
478435007010	IMP binding site; other site
478435007011	dimer interface [polypeptide binding]; other site
478435007012	interdomain contacts; other site
478435007013	partial ornithine binding site; other site
478435007014	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
478435007015	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
478435007016	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
478435007017	catalytic site [active]
478435007018	subunit interface [polypeptide binding]; other site
478435007019	dihydroorotase; Validated; Region: pyrC; PRK09357
478435007020	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
478435007021	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
478435007022	active site
478435007023	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
478435007024	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
478435007025	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
478435007026	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
478435007027	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
478435007028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435007029	S-adenosylmethionine binding site [chemical binding]; other site
478435007030	Uncharacterized conserved protein [Function unknown]; Region: COG3482
478435007031	uncharacterized domain; Region: TIGR00702
478435007032	YcaO-like family; Region: YcaO; pfam02624
478435007033	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
478435007034	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
478435007035	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
478435007036	malonyl-CoA binding site [chemical binding]; other site
478435007037	dimer interface [polypeptide binding]; other site
478435007038	active site
478435007039	product binding site; other site
478435007040	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
478435007041	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
478435007042	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
478435007043	putative di-iron ligands [ion binding]; other site
478435007044	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
478435007045	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435007046	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435007047	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
478435007048	synthetase active site [active]
478435007049	NTP binding site [chemical binding]; other site
478435007050	metal binding site [ion binding]; metal-binding site
478435007051	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435007052	anti sigma factor interaction site; other site
478435007053	regulatory phosphorylation site [posttranslational modification]; other site
478435007054	PAS fold; Region: PAS_4; pfam08448
478435007055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
478435007056	putative active site [active]
478435007057	heme pocket [chemical binding]; other site
478435007058	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
478435007059	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
478435007060	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
478435007061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
478435007062	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435007063	anti sigma factor interaction site; other site
478435007064	regulatory phosphorylation site [posttranslational modification]; other site
478435007065	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435007066	PPE family; Region: PPE; pfam00823
478435007067	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435007068	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
478435007069	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435007070	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007071	cyclase homology domain; Region: CHD; cd07302
478435007072	Predicted ATPase [General function prediction only]; Region: COG3903
478435007073	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435007074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435007075	DNA binding residues [nucleotide binding]
478435007076	dimerization interface [polypeptide binding]; other site
478435007077	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007078	cyclase homology domain; Region: CHD; cd07302
478435007079	nucleotidyl binding site; other site
478435007080	dimer interface [polypeptide binding]; other site
478435007081	metal binding site [ion binding]; metal-binding site
478435007082	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
478435007083	hypothetical protein; Provisional; Region: PRK07877
478435007084	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
478435007085	ATP binding site [chemical binding]; other site
478435007086	substrate interface [chemical binding]; other site
478435007087	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
478435007088	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
478435007089	GAF domain; Region: GAF; pfam01590
478435007090	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
478435007091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
478435007092	metal binding site [ion binding]; metal-binding site
478435007093	active site
478435007094	I-site; other site
478435007095	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
478435007096	tetracycline repressor protein TetR; Provisional; Region: PRK13756
478435007097	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435007098	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
478435007099	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
478435007100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435007101	NAD(P) binding site [chemical binding]; other site
478435007102	active site
478435007103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435007104	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
478435007105	Walker A/P-loop; other site
478435007106	ATP binding site [chemical binding]; other site
478435007107	Q-loop/lid; other site
478435007108	ABC transporter signature motif; other site
478435007109	Walker B; other site
478435007110	D-loop; other site
478435007111	H-loop/switch region; other site
478435007112	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
478435007113	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
478435007114	FAD binding pocket [chemical binding]; other site
478435007115	FAD binding motif [chemical binding]; other site
478435007116	phosphate binding motif [ion binding]; other site
478435007117	NAD binding pocket [chemical binding]; other site
478435007118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435007119	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
478435007120	Walker A/P-loop; other site
478435007121	ATP binding site [chemical binding]; other site
478435007122	Q-loop/lid; other site
478435007123	ABC transporter signature motif; other site
478435007124	Walker B; other site
478435007125	D-loop; other site
478435007126	H-loop/switch region; other site
478435007127	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
478435007128	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
478435007129	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435007130	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435007131	active site
478435007132	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
478435007133	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435007134	acyl-activating enzyme (AAE) consensus motif; other site
478435007135	active site
478435007136	acyl carrier protein; Validated; Region: PRK05883
478435007137	Glucitol operon activator [Transcription]; Region: GutM; COG4578
478435007138	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
478435007139	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
478435007140	active site
478435007141	dimerization interface [polypeptide binding]; other site
478435007142	ribonuclease PH; Reviewed; Region: rph; PRK00173
478435007143	Ribonuclease PH; Region: RNase_PH_bact; cd11362
478435007144	hexamer interface [polypeptide binding]; other site
478435007145	active site
478435007146	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
478435007147	glutamate racemase; Provisional; Region: PRK00865
478435007148	Rhomboid family; Region: Rhomboid; pfam01694
478435007149	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
478435007150	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
478435007151	dimer interface [polypeptide binding]; other site
478435007152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435007153	catalytic residue [active]
478435007154	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
478435007155	MoaE interaction surface [polypeptide binding]; other site
478435007156	MoeB interaction surface [polypeptide binding]; other site
478435007157	thiocarboxylated glycine; other site
478435007158	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
478435007159	MPN+ (JAMM) motif; other site
478435007160	Zinc-binding site [ion binding]; other site
478435007161	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
478435007162	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
478435007163	putative active site pocket [active]
478435007164	cleavage site
478435007165	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
478435007166	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
478435007167	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
478435007168	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
478435007169	active site
478435007170	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
478435007171	DEAD/DEAH box helicase; Region: DEAD; pfam00270
478435007172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
478435007173	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
478435007174	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
478435007175	putative homodimer interface [polypeptide binding]; other site
478435007176	putative active site pocket [active]
478435007177	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
478435007178	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
478435007179	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
478435007180	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
478435007181	active site
478435007182	homodimer interface [polypeptide binding]; other site
478435007183	catalytic site [active]
478435007184	acceptor binding site [chemical binding]; other site
478435007185	glycogen branching enzyme; Provisional; Region: PRK05402
478435007186	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
478435007187	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
478435007188	active site
478435007189	catalytic site [active]
478435007190	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
478435007191	PE family; Region: PE; pfam00934
478435007192	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
478435007193	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
478435007194	putative acyltransferase; Provisional; Region: PRK05790
478435007195	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435007196	dimer interface [polypeptide binding]; other site
478435007197	active site
478435007198	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435007199	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
478435007200	dimer interface [polypeptide binding]; other site
478435007201	substrate binding site [chemical binding]; other site
478435007202	metal binding site [ion binding]; metal-binding site
478435007203	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
478435007204	hypothetical protein; Provisional; Region: PRK03298
478435007205	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
478435007206	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435007207	dimerization interface [polypeptide binding]; other site
478435007208	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007209	cyclase homology domain; Region: CHD; cd07302
478435007210	nucleotidyl binding site; other site
478435007211	metal binding site [ion binding]; metal-binding site
478435007212	dimer interface [polypeptide binding]; other site
478435007213	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435007214	dimerization interface [polypeptide binding]; other site
478435007215	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007216	cyclase homology domain; Region: CHD; cd07302
478435007217	nucleotidyl binding site; other site
478435007218	metal binding site [ion binding]; metal-binding site
478435007219	dimer interface [polypeptide binding]; other site
478435007220	HAMP domain; Region: HAMP; pfam00672
478435007221	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007222	cyclase homology domain; Region: CHD; cd07302
478435007223	nucleotidyl binding site; other site
478435007224	metal binding site [ion binding]; metal-binding site
478435007225	dimer interface [polypeptide binding]; other site
478435007226	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
478435007227	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
478435007228	AlkA N-terminal domain; Region: AlkA_N; pfam06029
478435007229	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
478435007230	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
478435007231	minor groove reading motif; other site
478435007232	helix-hairpin-helix signature motif; other site
478435007233	substrate binding pocket [chemical binding]; other site
478435007234	active site
478435007235	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
478435007236	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
478435007237	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
478435007238	DNA binding site [nucleotide binding]
478435007239	active site
478435007240	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
478435007241	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
478435007242	hinge; other site
478435007243	active site
478435007244	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
478435007245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
478435007246	Transposase; Region: DDE_Tnp_ISL3; pfam01610
478435007247	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
478435007248	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
478435007249	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
478435007250	gamma subunit interface [polypeptide binding]; other site
478435007251	epsilon subunit interface [polypeptide binding]; other site
478435007252	LBP interface [polypeptide binding]; other site
478435007253	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
478435007254	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
478435007255	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
478435007256	alpha subunit interaction interface [polypeptide binding]; other site
478435007257	Walker A motif; other site
478435007258	ATP binding site [chemical binding]; other site
478435007259	Walker B motif; other site
478435007260	inhibitor binding site; inhibition site
478435007261	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
478435007262	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
478435007263	core domain interface [polypeptide binding]; other site
478435007264	delta subunit interface [polypeptide binding]; other site
478435007265	epsilon subunit interface [polypeptide binding]; other site
478435007266	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
478435007267	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
478435007268	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
478435007269	Walker A motif; other site
478435007270	ATP binding site [chemical binding]; other site
478435007271	Walker B motif; other site
478435007272	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
478435007273	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
478435007274	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
478435007275	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
478435007276	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
478435007277	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
478435007278	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
478435007279	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
478435007280	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
478435007281	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
478435007282	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
478435007283	Mg++ binding site [ion binding]; other site
478435007284	putative catalytic motif [active]
478435007285	substrate binding site [chemical binding]; other site
478435007286	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
478435007287	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
478435007288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435007289	S-adenosylmethionine binding site [chemical binding]; other site
478435007290	peptide chain release factor 1; Region: prfA; TIGR00019
478435007291	This domain is found in peptide chain release factors; Region: PCRF; smart00937
478435007292	RF-1 domain; Region: RF-1; pfam00472
478435007293	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
478435007294	transcription termination factor Rho; Provisional; Region: PRK12678
478435007295	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
478435007296	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
478435007297	RNA binding site [nucleotide binding]; other site
478435007298	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
478435007299	multimer interface [polypeptide binding]; other site
478435007300	Walker A motif; other site
478435007301	ATP binding site [chemical binding]; other site
478435007302	Walker B motif; other site
478435007303	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
478435007304	threonine synthase; Reviewed; Region: PRK06721
478435007305	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
478435007306	homodimer interface [polypeptide binding]; other site
478435007307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435007308	catalytic residue [active]
478435007309	homoserine dehydrogenase; Provisional; Region: PRK06349
478435007310	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
478435007311	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
478435007312	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
478435007313	diaminopimelate decarboxylase; Region: lysA; TIGR01048
478435007314	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
478435007315	active site
478435007316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
478435007317	substrate binding site [chemical binding]; other site
478435007318	catalytic residues [active]
478435007319	dimer interface [polypeptide binding]; other site
478435007320	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
478435007321	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
478435007322	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
478435007323	active site
478435007324	HIGH motif; other site
478435007325	KMSK motif region; other site
478435007326	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
478435007327	tRNA binding surface [nucleotide binding]; other site
478435007328	anticodon binding site; other site
478435007329	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435007330	Predicted membrane protein [Function unknown]; Region: COG4325
478435007331	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
478435007332	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
478435007333	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
478435007334	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
478435007335	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
478435007336	Putative esterase; Region: Esterase; pfam00756
478435007337	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
478435007338	Rrf2 family protein; Region: rrf2_super; TIGR00738
478435007339	Transcriptional regulator; Region: Rrf2; pfam02082
478435007340	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
478435007341	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
478435007342	CysD dimerization site [polypeptide binding]; other site
478435007343	G1 box; other site
478435007344	putative GEF interaction site [polypeptide binding]; other site
478435007345	GTP/Mg2+ binding site [chemical binding]; other site
478435007346	Switch I region; other site
478435007347	G2 box; other site
478435007348	G3 box; other site
478435007349	Switch II region; other site
478435007350	G4 box; other site
478435007351	G5 box; other site
478435007352	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
478435007353	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
478435007354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435007355	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
478435007356	Walker A/P-loop; other site
478435007357	ligand-binding site [chemical binding]; other site
478435007358	ATP binding site [chemical binding]; other site
478435007359	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
478435007360	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
478435007361	Active Sites [active]
478435007362	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
478435007363	active site clefts [active]
478435007364	zinc binding site [ion binding]; other site
478435007365	dimer interface [polypeptide binding]; other site
478435007366	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
478435007367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435007368	dimer interface [polypeptide binding]; other site
478435007369	conserved gate region; other site
478435007370	putative PBP binding loops; other site
478435007371	ABC-ATPase subunit interface; other site
478435007372	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
478435007373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435007374	dimer interface [polypeptide binding]; other site
478435007375	conserved gate region; other site
478435007376	putative PBP binding loops; other site
478435007377	ABC-ATPase subunit interface; other site
478435007378	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
478435007379	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
478435007380	Walker A/P-loop; other site
478435007381	ATP binding site [chemical binding]; other site
478435007382	Q-loop/lid; other site
478435007383	ABC transporter signature motif; other site
478435007384	Walker B; other site
478435007385	D-loop; other site
478435007386	H-loop/switch region; other site
478435007387	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
478435007388	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
478435007389	Walker A/P-loop; other site
478435007390	ATP binding site [chemical binding]; other site
478435007391	Q-loop/lid; other site
478435007392	ABC transporter signature motif; other site
478435007393	Walker B; other site
478435007394	D-loop; other site
478435007395	H-loop/switch region; other site
478435007396	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
478435007397	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
478435007398	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
478435007399	choline dehydrogenase; Validated; Region: PRK02106
478435007400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435007401	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
478435007402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435007403	Walker A/P-loop; other site
478435007404	ATP binding site [chemical binding]; other site
478435007405	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
478435007406	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
478435007407	active site
478435007408	metal binding site [ion binding]; metal-binding site
478435007409	DNA binding site [nucleotide binding]
478435007410	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435007411	catalytic core [active]
478435007412	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
478435007413	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
478435007414	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
478435007415	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
478435007416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
478435007417	Walker A/P-loop; other site
478435007418	ATP binding site [chemical binding]; other site
478435007419	Q-loop/lid; other site
478435007420	ABC transporter signature motif; other site
478435007421	Walker B; other site
478435007422	D-loop; other site
478435007423	H-loop/switch region; other site
478435007424	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
478435007425	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
478435007426	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
478435007427	Walker A/P-loop; other site
478435007428	ATP binding site [chemical binding]; other site
478435007429	Q-loop/lid; other site
478435007430	ABC transporter signature motif; other site
478435007431	Walker B; other site
478435007432	D-loop; other site
478435007433	H-loop/switch region; other site
478435007434	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435007435	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
478435007436	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
478435007437	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
478435007438	putative active site [active]
478435007439	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
478435007440	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
478435007441	DNA binding site [nucleotide binding]
478435007442	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435007443	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435007444	phosphopeptide binding site; other site
478435007445	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435007446	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435007447	active site
478435007448	ATP binding site [chemical binding]; other site
478435007449	substrate binding site [chemical binding]; other site
478435007450	activation loop (A-loop); other site
478435007451	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435007452	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007453	cyclase homology domain; Region: CHD; cd07302
478435007454	nucleotidyl binding site; other site
478435007455	metal binding site [ion binding]; metal-binding site
478435007456	dimer interface [polypeptide binding]; other site
478435007457	amidase; Provisional; Region: PRK12470
478435007458	Amidase; Region: Amidase; pfam01425
478435007459	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
478435007460	HIT family signature motif; other site
478435007461	catalytic residue [active]
478435007462	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435007463	hypothetical protein; Validated; Region: PRK05868
478435007464	hypothetical protein; Provisional; Region: PRK07236
478435007465	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
478435007466	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
478435007467	Fe-S cluster binding site [ion binding]; other site
478435007468	DNA binding site [nucleotide binding]
478435007469	active site
478435007470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435007471	H+ Antiporter protein; Region: 2A0121; TIGR00900
478435007472	putative substrate translocation pore; other site
478435007473	FAD binding domain; Region: FAD_binding_4; pfam01565
478435007474	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
478435007475	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435007476	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435007477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435007478	Acyltransferase family; Region: Acyl_transf_3; pfam01757
478435007479	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
478435007480	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
478435007481	ATP binding site [chemical binding]; other site
478435007482	Mg++ binding site [ion binding]; other site
478435007483	motif III; other site
478435007484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435007485	nucleotide binding region [chemical binding]; other site
478435007486	ATP-binding site [chemical binding]; other site
478435007487	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
478435007488	putative RNA binding site [nucleotide binding]; other site
478435007489	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
478435007490	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
478435007491	RNase_H superfamily; Region: RNase_H_2; pfam13482
478435007492	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
478435007493	Part of AAA domain; Region: AAA_19; pfam13245
478435007494	AAA domain; Region: AAA_12; pfam13087
478435007495	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435007496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435007497	putative substrate translocation pore; other site
478435007498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435007499	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
478435007500	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
478435007501	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
478435007502	TPP-binding site [chemical binding]; other site
478435007503	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
478435007504	dimer interface [polypeptide binding]; other site
478435007505	PYR/PP interface [polypeptide binding]; other site
478435007506	TPP binding site [chemical binding]; other site
478435007507	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
478435007508	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
478435007509	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
478435007510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435007511	NAD(P) binding site [chemical binding]; other site
478435007512	active site
478435007513	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
478435007514	PE family; Region: PE; pfam00934
478435007515	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435007516	malate dehydrogenase; Provisional; Region: PRK05442
478435007517	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
478435007518	NAD(P) binding site [chemical binding]; other site
478435007519	dimer interface [polypeptide binding]; other site
478435007520	malate binding site [chemical binding]; other site
478435007521	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
478435007522	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
478435007523	oligomer interface [polypeptide binding]; other site
478435007524	metal binding site [ion binding]; metal-binding site
478435007525	metal binding site [ion binding]; metal-binding site
478435007526	putative Cl binding site [ion binding]; other site
478435007527	basic sphincter; other site
478435007528	hydrophobic gate; other site
478435007529	periplasmic entrance; other site
478435007530	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
478435007531	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
478435007532	Walker A/P-loop; other site
478435007533	ATP binding site [chemical binding]; other site
478435007534	Q-loop/lid; other site
478435007535	ABC transporter signature motif; other site
478435007536	Walker B; other site
478435007537	D-loop; other site
478435007538	H-loop/switch region; other site
478435007539	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
478435007540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435007541	dimer interface [polypeptide binding]; other site
478435007542	conserved gate region; other site
478435007543	ABC-ATPase subunit interface; other site
478435007544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435007545	dimer interface [polypeptide binding]; other site
478435007546	conserved gate region; other site
478435007547	putative PBP binding loops; other site
478435007548	ABC-ATPase subunit interface; other site
478435007549	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
478435007550	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
478435007551	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
478435007552	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
478435007553	MgtE intracellular N domain; Region: MgtE_N; smart00924
478435007554	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
478435007555	Predicted membrane protein [Function unknown]; Region: COG4420
478435007556	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
478435007557	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
478435007558	N-acetyl-D-glucosamine binding site [chemical binding]; other site
478435007559	catalytic residue [active]
478435007560	Domain of unknown function DUF59; Region: DUF59; cl00941
478435007561	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
478435007562	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
478435007563	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
478435007564	Uncharacterized conserved protein [Function unknown]; Region: COG3402
478435007565	Predicted membrane protein [Function unknown]; Region: COG3428
478435007566	Bacterial PH domain; Region: DUF304; pfam03703
478435007567	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
478435007568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435007569	active site
478435007570	motif I; other site
478435007571	motif II; other site
478435007572	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435007573	sec-independent translocase; Provisional; Region: PRK03100
478435007574	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
478435007575	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
478435007576	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
478435007577	protein binding site [polypeptide binding]; other site
478435007578	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
478435007579	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435007580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435007581	DNA binding residues [nucleotide binding]
478435007582	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
478435007583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435007584	S-adenosylmethionine binding site [chemical binding]; other site
478435007585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435007586	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
478435007587	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
478435007588	Walker A/P-loop; other site
478435007589	ATP binding site [chemical binding]; other site
478435007590	Q-loop/lid; other site
478435007591	ABC transporter signature motif; other site
478435007592	Walker B; other site
478435007593	D-loop; other site
478435007594	H-loop/switch region; other site
478435007595	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
478435007596	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
478435007597	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
478435007598	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
478435007599	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
478435007600	PE family; Region: PE; pfam00934
478435007601	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
478435007602	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
478435007603	ligand binding site; other site
478435007604	oligomer interface; other site
478435007605	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
478435007606	dimer interface [polypeptide binding]; other site
478435007607	N-terminal domain interface [polypeptide binding]; other site
478435007608	sulfate 1 binding site; other site
478435007609	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
478435007610	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
478435007611	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
478435007612	DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624
478435007613	DivIVA domain; Region: DivI1A_domain; TIGR03544
478435007614	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
478435007615	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
478435007616	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
478435007617	dihydropteroate synthase; Region: DHPS; TIGR01496
478435007618	substrate binding pocket [chemical binding]; other site
478435007619	dimer interface [polypeptide binding]; other site
478435007620	inhibitor binding site; inhibition site
478435007621	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
478435007622	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
478435007623	acyl-activating enzyme (AAE) consensus motif; other site
478435007624	putative AMP binding site [chemical binding]; other site
478435007625	putative active site [active]
478435007626	putative CoA binding site [chemical binding]; other site
478435007627	TIGR00730 family protein; Region: TIGR00730
478435007628	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
478435007629	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
478435007630	putative trimer interface [polypeptide binding]; other site
478435007631	putative CoA binding site [chemical binding]; other site
478435007632	metabolite-proton symporter; Region: 2A0106; TIGR00883
478435007633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435007634	putative substrate translocation pore; other site
478435007635	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435007636	MULE transposase domain; Region: MULE; pfam10551
478435007637	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435007638	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
478435007639	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435007640	PPE family; Region: PPE; pfam00823
478435007641	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435007642	PE family; Region: PE; pfam00934
478435007643	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435007644	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
478435007645	acyl-CoA synthetase; Validated; Region: PRK07787
478435007646	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435007647	acyl-activating enzyme (AAE) consensus motif; other site
478435007648	AMP binding site [chemical binding]; other site
478435007649	active site
478435007650	CoA binding site [chemical binding]; other site
478435007651	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
478435007652	PGAP1-like protein; Region: PGAP1; pfam07819
478435007653	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435007654	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
478435007655	haloalkane dehalogenase; Provisional; Region: PRK03204
478435007656	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
478435007657	catalytic site [active]
478435007658	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
478435007659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435007660	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435007661	DNA binding residues [nucleotide binding]
478435007662	Proline dehydrogenase; Region: Pro_dh; pfam01619
478435007663	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
478435007664	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
478435007665	Glutamate binding site [chemical binding]; other site
478435007666	NAD binding site [chemical binding]; other site
478435007667	catalytic residues [active]
478435007668	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
478435007669	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
478435007670	acyl-CoA synthetase; Validated; Region: PRK05850
478435007671	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435007672	acyl-activating enzyme (AAE) consensus motif; other site
478435007673	active site
478435007674	PE-PPE domain; Region: PE-PPE; pfam08237
478435007675	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435007676	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
478435007677	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435007678	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435007679	active site
478435007680	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435007681	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435007682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435007683	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435007684	Enoylreductase; Region: PKS_ER; smart00829
478435007685	NAD(P) binding site [chemical binding]; other site
478435007686	KR domain; Region: KR; pfam08659
478435007687	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435007688	putative NADP binding site [chemical binding]; other site
478435007689	active site
478435007690	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435007691	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
478435007692	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
478435007693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
478435007694	ATP binding site [chemical binding]; other site
478435007695	putative Mg++ binding site [ion binding]; other site
478435007696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
478435007697	ATP-binding site [chemical binding]; other site
478435007698	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
478435007699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435007700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435007701	homodimer interface [polypeptide binding]; other site
478435007702	catalytic residue [active]
478435007703	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
478435007704	4Fe-4S binding domain; Region: Fer4; pfam00037
478435007705	Predicted transcriptional regulators [Transcription]; Region: COG1695
478435007706	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
478435007707	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
478435007708	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
478435007709	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
478435007710	active site
478435007711	FMN binding site [chemical binding]; other site
478435007712	2,4-decadienoyl-CoA binding site; other site
478435007713	catalytic residue [active]
478435007714	4Fe-4S cluster binding site [ion binding]; other site
478435007715	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
478435007716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435007717	FO synthase; Reviewed; Region: fbiC; PRK09234
478435007718	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435007719	FeS/SAM binding site; other site
478435007720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435007721	FeS/SAM binding site; other site
478435007722	PE family; Region: PE; pfam00934
478435007723	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
478435007724	PE family; Region: PE; pfam00934
478435007725	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435007726	PPE family; Region: PPE; pfam00823
478435007727	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435007728	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435007729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435007730	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
478435007731	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
478435007732	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
478435007733	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
478435007734	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
478435007735	G1 box; other site
478435007736	putative GEF interaction site [polypeptide binding]; other site
478435007737	GTP/Mg2+ binding site [chemical binding]; other site
478435007738	Switch I region; other site
478435007739	G2 box; other site
478435007740	G3 box; other site
478435007741	Switch II region; other site
478435007742	G4 box; other site
478435007743	G5 box; other site
478435007744	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
478435007745	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
478435007746	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
478435007747	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
478435007748	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
478435007749	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
478435007750	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
478435007751	[4Fe-4S] binding site [ion binding]; other site
478435007752	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435007753	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435007754	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
478435007755	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
478435007756	molybdopterin cofactor binding site; other site
478435007757	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
478435007758	active site
478435007759	8-oxo-dGMP binding site [chemical binding]; other site
478435007760	nudix motif; other site
478435007761	metal binding site [ion binding]; metal-binding site
478435007762	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
478435007763	aromatic arch; other site
478435007764	DCoH dimer interaction site [polypeptide binding]; other site
478435007765	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
478435007766	DCoH tetramer interaction site [polypeptide binding]; other site
478435007767	substrate binding site [chemical binding]; other site
478435007768	mannosyltransferase; Provisional; Region: pimE; PRK13375
478435007769	uncharacterized HhH-GPD family protein; Region: TIGR03252
478435007770	minor groove reading motif; other site
478435007771	helix-hairpin-helix signature motif; other site
478435007772	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
478435007773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
478435007774	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435007775	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
478435007776	Predicted transcriptional regulators [Transcription]; Region: COG1725
478435007777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
478435007778	DNA-binding site [nucleotide binding]; DNA binding site
478435007779	NAD-dependent deacetylase; Provisional; Region: PRK00481
478435007780	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
478435007781	NAD+ binding site [chemical binding]; other site
478435007782	substrate binding site [chemical binding]; other site
478435007783	Zn binding site [ion binding]; other site
478435007784	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
478435007785	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
478435007786	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435007787	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435007788	active site
478435007789	DDE superfamily endonuclease; Region: DDE_5; cl17874
478435007790	MMPL family; Region: MMPL; pfam03176
478435007791	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435007792	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
478435007793	NAD binding site [chemical binding]; other site
478435007794	homodimer interface [polypeptide binding]; other site
478435007795	homotetramer interface [polypeptide binding]; other site
478435007796	active site
478435007797	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
478435007798	CoA-transferase family III; Region: CoA_transf_3; pfam02515
478435007799	enoyl-CoA hydratase; Provisional; Region: PRK06688
478435007800	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435007801	substrate binding site [chemical binding]; other site
478435007802	oxyanion hole (OAH) forming residues; other site
478435007803	trimer interface [polypeptide binding]; other site
478435007804	enoyl-CoA hydratase; Provisional; Region: PRK06688
478435007805	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
478435007806	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435007807	trimer interface [polypeptide binding]; other site
478435007808	CAAX protease self-immunity; Region: Abi; pfam02517
478435007809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
478435007810	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
478435007811	enoyl-CoA hydratase; Provisional; Region: PRK06494
478435007812	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435007813	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435007814	substrate binding site [chemical binding]; other site
478435007815	oxyanion hole (OAH) forming residues; other site
478435007816	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
478435007817	active site
478435007818	PPE family; Region: PPE; pfam00823
478435007819	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435007820	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
478435007821	citrate synthase; Provisional; Region: PRK14033
478435007822	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
478435007823	oxalacetate binding site [chemical binding]; other site
478435007824	citrylCoA binding site [chemical binding]; other site
478435007825	coenzyme A binding site [chemical binding]; other site
478435007826	catalytic triad [active]
478435007827	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
478435007828	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
478435007829	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435007830	non-specific DNA binding site [nucleotide binding]; other site
478435007831	salt bridge; other site
478435007832	sequence-specific DNA binding site [nucleotide binding]; other site
478435007833	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
478435007834	Domain of unknown function (DUF955); Region: DUF955; pfam06114
478435007835	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
478435007836	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435007837	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435007838	active site
478435007839	pyruvate phosphate dikinase; Provisional; Region: PRK05878
478435007840	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
478435007841	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
478435007842	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435007843	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435007844	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
478435007845	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
478435007846	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
478435007847	glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871
478435007848	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
478435007849	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
478435007850	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435007851	cyclase homology domain; Region: CHD; cd07302
478435007852	nucleotidyl binding site; other site
478435007853	metal binding site [ion binding]; metal-binding site
478435007854	dimer interface [polypeptide binding]; other site
478435007855	Uncharacterized conserved protein [Function unknown]; Region: COG1359
478435007856	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
478435007857	putative active site [active]
478435007858	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
478435007859	GTP-binding protein YchF; Reviewed; Region: PRK09601
478435007860	YchF GTPase; Region: YchF; cd01900
478435007861	G1 box; other site
478435007862	GTP/Mg2+ binding site [chemical binding]; other site
478435007863	Switch I region; other site
478435007864	G2 box; other site
478435007865	Switch II region; other site
478435007866	G3 box; other site
478435007867	G4 box; other site
478435007868	G5 box; other site
478435007869	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
478435007870	Yip1 domain; Region: Yip1; pfam04893
478435007871	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
478435007872	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
478435007873	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
478435007874	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
478435007875	generic binding surface II; other site
478435007876	generic binding surface I; other site
478435007877	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
478435007878	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
478435007879	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
478435007880	putative NAD(P) binding site [chemical binding]; other site
478435007881	active site
478435007882	putative substrate binding site [chemical binding]; other site
478435007883	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435007884	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435007885	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
478435007886	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
478435007887	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
478435007888	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
478435007889	Domain of unknown function DUF20; Region: UPF0118; pfam01594
478435007890	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
478435007891	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
478435007892	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
478435007893	putative active site [active]
478435007894	fumarate hydratase; Reviewed; Region: fumC; PRK00485
478435007895	Class II fumarases; Region: Fumarase_classII; cd01362
478435007896	active site
478435007897	tetramer interface [polypeptide binding]; other site
478435007898	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
478435007899	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
478435007900	NodB motif; other site
478435007901	active site
478435007902	catalytic site [active]
478435007903	metal binding site [ion binding]; metal-binding site
478435007904	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
478435007905	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
478435007906	putative active site [active]
478435007907	PhoH-like protein; Region: PhoH; pfam02562
478435007908	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
478435007909	dinuclear metal binding motif [ion binding]; other site
478435007910	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
478435007911	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
478435007912	dimer interface [polypeptide binding]; other site
478435007913	active site
478435007914	glycine-pyridoxal phosphate binding site [chemical binding]; other site
478435007915	folate binding site [chemical binding]; other site
478435007916	pantothenate kinase; Provisional; Region: PRK05439
478435007917	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
478435007918	ATP-binding site [chemical binding]; other site
478435007919	CoA-binding site [chemical binding]; other site
478435007920	Mg2+-binding site [ion binding]; other site
478435007921	PE family; Region: PE; pfam00934
478435007922	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670
478435007923	PE family; Region: PE; pfam00934
478435007924	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
478435007925	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
478435007926	putative IPP diphosphate binding site; other site
478435007927	PE family; Region: PE; pfam00934
478435007928	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
478435007929	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
478435007930	catalytic residue [active]
478435007931	putative FPP diphosphate  binding site; other site
478435007932	putative FPP binding hydrophobic cleft; other site
478435007933	dimer interface [polypeptide binding]; other site
478435007934	putative IPP diphosphate binding site; other site
478435007935	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
478435007936	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
478435007937	catalytic residues [active]
478435007938	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
478435007939	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
478435007940	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
478435007941	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
478435007942	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
478435007943	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
478435007944	cystathionine gamma-synthase; Provisional; Region: PRK07811
478435007945	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
478435007946	homodimer interface [polypeptide binding]; other site
478435007947	substrate-cofactor binding pocket; other site
478435007948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435007949	catalytic residue [active]
478435007950	RDD family; Region: RDD; pfam06271
478435007951	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
478435007952	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
478435007953	dimer interface [polypeptide binding]; other site
478435007954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435007955	catalytic residue [active]
478435007956	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
478435007957	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
478435007958	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
478435007959	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
478435007960	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435007961	dimer interface [polypeptide binding]; other site
478435007962	active site
478435007963	Predicted membrane protein [Function unknown]; Region: COG4760
478435007964	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
478435007965	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435007966	substrate binding site [chemical binding]; other site
478435007967	oxyanion hole (OAH) forming residues; other site
478435007968	trimer interface [polypeptide binding]; other site
478435007969	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
478435007970	enoyl-CoA hydratase; Provisional; Region: PRK05862
478435007971	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435007972	substrate binding site [chemical binding]; other site
478435007973	oxyanion hole (OAH) forming residues; other site
478435007974	trimer interface [polypeptide binding]; other site
478435007975	Predicted membrane protein [Function unknown]; Region: COG4425
478435007976	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
478435007977	PE family; Region: PE; pfam00934
478435007978	PE family; Region: PE; pfam00934
478435007979	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
478435007980	active site residue [active]
478435007981	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
478435007982	hypothetical protein; Provisional; Region: PRK10279
478435007983	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
478435007984	active site
478435007985	nucleophile elbow; other site
478435007986	Patatin-like phospholipase; Region: Patatin; pfam01734
478435007987	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
478435007988	nucleophile elbow; other site
478435007989	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
478435007990	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
478435007991	putative active site [active]
478435007992	putative dimer interface [polypeptide binding]; other site
478435007993	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
478435007994	hydrophobic ligand binding site; other site
478435007995	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
478435007996	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
478435007997	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
478435007998	dimer interface [polypeptide binding]; other site
478435007999	acyl-activating enzyme (AAE) consensus motif; other site
478435008000	putative active site [active]
478435008001	AMP binding site [chemical binding]; other site
478435008002	putative CoA binding site [chemical binding]; other site
478435008003	Uncharacterized conserved protein [Function unknown]; Region: COG3391
478435008004	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435008005	Domain of unknown function (DUF427); Region: DUF427; cl00998
478435008006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
478435008007	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435008008	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
478435008009	Helix-turn-helix domain; Region: HTH_17; pfam12728
478435008010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435008011	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
478435008012	NAD(P) binding site [chemical binding]; other site
478435008013	active site
478435008014	Transcriptional regulators [Transcription]; Region: MarR; COG1846
478435008015	MarR family; Region: MarR_2; pfam12802
478435008016	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435008017	MULE transposase domain; Region: MULE; pfam10551
478435008018	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
478435008019	Predicted transcriptional regulator [Transcription]; Region: COG5340
478435008020	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
478435008021	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
478435008022	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
478435008023	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
478435008024	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
478435008025	PE family; Region: PE; pfam00934
478435008026	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435008027	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008028	PPE family; Region: PPE; pfam00823
478435008029	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435008030	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
478435008031	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435008032	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
478435008033	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
478435008034	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
478435008035	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435008036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008037	active site
478435008038	phosphorylation site [posttranslational modification]
478435008039	intermolecular recognition site; other site
478435008040	dimerization interface [polypeptide binding]; other site
478435008041	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435008042	DNA binding site [nucleotide binding]
478435008043	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435008044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435008045	dimer interface [polypeptide binding]; other site
478435008046	phosphorylation site [posttranslational modification]
478435008047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008048	ATP binding site [chemical binding]; other site
478435008049	Mg2+ binding site [ion binding]; other site
478435008050	G-X-G motif; other site
478435008051	potassium-transporting ATPase subunit C; Provisional; Region: PRK14001
478435008052	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
478435008053	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435008054	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435008055	K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680
478435008056	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
478435008057	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
478435008058	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
478435008059	Ligand Binding Site [chemical binding]; other site
478435008060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435008061	dimer interface [polypeptide binding]; other site
478435008062	phosphorylation site [posttranslational modification]
478435008063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008064	ATP binding site [chemical binding]; other site
478435008065	Mg2+ binding site [ion binding]; other site
478435008066	G-X-G motif; other site
478435008067	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
478435008068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008069	active site
478435008070	phosphorylation site [posttranslational modification]
478435008071	intermolecular recognition site; other site
478435008072	dimerization interface [polypeptide binding]; other site
478435008073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435008074	DNA binding site [nucleotide binding]
478435008075	exopolyphosphatase; Region: exo_poly_only; TIGR03706
478435008076	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
478435008077	Uncharacterized conserved protein [Function unknown]; Region: COG1507
478435008078	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
478435008079	Septum formation initiator; Region: DivIC; pfam04977
478435008080	enolase; Provisional; Region: eno; PRK00077
478435008081	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
478435008082	dimer interface [polypeptide binding]; other site
478435008083	metal binding site [ion binding]; metal-binding site
478435008084	substrate binding pocket [chemical binding]; other site
478435008085	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
478435008086	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
478435008087	N-acetyl-D-glucosamine binding site [chemical binding]; other site
478435008088	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
478435008089	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
478435008090	homodimer interface [polypeptide binding]; other site
478435008091	metal binding site [ion binding]; metal-binding site
478435008092	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
478435008093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435008094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435008095	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
478435008096	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
478435008097	Substrate binding site; other site
478435008098	Mg++ binding site; other site
478435008099	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
478435008100	active site
478435008101	substrate binding site [chemical binding]; other site
478435008102	CoA binding site [chemical binding]; other site
478435008103	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
478435008104	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
478435008105	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435008106	active site
478435008107	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
478435008108	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
478435008109	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
478435008110	5S rRNA interface [nucleotide binding]; other site
478435008111	CTC domain interface [polypeptide binding]; other site
478435008112	L16 interface [polypeptide binding]; other site
478435008113	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
478435008114	putative active site [active]
478435008115	catalytic residue [active]
478435008116	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
478435008117	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435008118	acyl-activating enzyme (AAE) consensus motif; other site
478435008119	AMP binding site [chemical binding]; other site
478435008120	active site
478435008121	CoA binding site [chemical binding]; other site
478435008122	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
478435008123	Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311
478435008124	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
478435008125	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
478435008126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435008127	S-adenosylmethionine binding site [chemical binding]; other site
478435008128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
478435008129	Domain of unknown function (DUF348); Region: DUF348; pfam03990
478435008130	Domain of unknown function (DUF348); Region: DUF348; pfam03990
478435008131	G5 domain; Region: G5; pfam07501
478435008132	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
478435008133	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
478435008134	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
478435008135	active site
478435008136	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
478435008137	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
478435008138	active site
478435008139	HIGH motif; other site
478435008140	KMSKS motif; other site
478435008141	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
478435008142	tRNA binding surface [nucleotide binding]; other site
478435008143	anticodon binding site; other site
478435008144	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
478435008145	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
478435008146	Predicted methyltransferases [General function prediction only]; Region: COG0313
478435008147	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
478435008148	putative SAM binding site [chemical binding]; other site
478435008149	putative homodimer interface [polypeptide binding]; other site
478435008150	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
478435008151	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
478435008152	arginine deiminase; Provisional; Region: PRK01388
478435008153	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
478435008154	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435008155	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435008156	ligand binding site [chemical binding]; other site
478435008157	flexible hinge region; other site
478435008158	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
478435008159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435008160	Coenzyme A binding pocket [chemical binding]; other site
478435008161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
478435008162	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
478435008163	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
478435008164	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
478435008165	dimer interface [polypeptide binding]; other site
478435008166	putative functional site; other site
478435008167	putative MPT binding site; other site
478435008168	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
478435008169	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
478435008170	active site
478435008171	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
478435008172	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
478435008173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
478435008174	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
478435008175	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
478435008176	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
478435008177	substrate binding pocket [chemical binding]; other site
478435008178	chain length determination region; other site
478435008179	substrate-Mg2+ binding site; other site
478435008180	catalytic residues [active]
478435008181	aspartate-rich region 1; other site
478435008182	active site lid residues [active]
478435008183	aspartate-rich region 2; other site
478435008184	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
478435008185	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
478435008186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
478435008187	FtsX-like permease family; Region: FtsX; pfam02687
478435008188	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
478435008189	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
478435008190	FtsX-like permease family; Region: FtsX; pfam02687
478435008191	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
478435008192	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
478435008193	Walker A/P-loop; other site
478435008194	ATP binding site [chemical binding]; other site
478435008195	Q-loop/lid; other site
478435008196	ABC transporter signature motif; other site
478435008197	Walker B; other site
478435008198	D-loop; other site
478435008199	H-loop/switch region; other site
478435008200	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
478435008201	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
478435008202	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
478435008203	MPT binding site; other site
478435008204	trimer interface [polypeptide binding]; other site
478435008205	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
478435008206	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
478435008207	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
478435008208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435008209	dimerization interface [polypeptide binding]; other site
478435008210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435008211	dimer interface [polypeptide binding]; other site
478435008212	phosphorylation site [posttranslational modification]
478435008213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008214	ATP binding site [chemical binding]; other site
478435008215	Mg2+ binding site [ion binding]; other site
478435008216	G-X-G motif; other site
478435008217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435008218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008219	active site
478435008220	phosphorylation site [posttranslational modification]
478435008221	intermolecular recognition site; other site
478435008222	dimerization interface [polypeptide binding]; other site
478435008223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435008224	DNA binding site [nucleotide binding]
478435008225	PE family; Region: PE; pfam00934
478435008226	Uncharacterized conserved protein [Function unknown]; Region: COG3391
478435008227	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
478435008228	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
478435008229	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
478435008230	PE family; Region: PE; pfam00934
478435008231	Uncharacterized conserved protein [Function unknown]; Region: COG3391
478435008232	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
478435008233	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
478435008234	PE family; Region: PE; pfam00934
478435008235	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
478435008236	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435008237	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435008238	active site
478435008239	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
478435008240	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
478435008241	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
478435008242	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435008243	ATP-grasp domain; Region: ATP-grasp_4; cl17255
478435008244	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
478435008245	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
478435008246	carboxyltransferase (CT) interaction site; other site
478435008247	biotinylation site [posttranslational modification]; other site
478435008248	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435008249	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
478435008250	active site
478435008251	enoyl-CoA hydratase; Provisional; Region: PRK07827
478435008252	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435008253	substrate binding site [chemical binding]; other site
478435008254	oxyanion hole (OAH) forming residues; other site
478435008255	trimer interface [polypeptide binding]; other site
478435008256	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
478435008257	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435008258	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435008259	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
478435008260	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
478435008261	putative homodimer interface [polypeptide binding]; other site
478435008262	putative homotetramer interface [polypeptide binding]; other site
478435008263	allosteric switch controlling residues; other site
478435008264	putative metal binding site [ion binding]; other site
478435008265	putative homodimer-homodimer interface [polypeptide binding]; other site
478435008266	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
478435008267	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
478435008268	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
478435008269	homotetrameric interface [polypeptide binding]; other site
478435008270	putative active site [active]
478435008271	metal binding site [ion binding]; metal-binding site
478435008272	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
478435008273	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
478435008274	metal ion-dependent adhesion site (MIDAS); other site
478435008275	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
478435008276	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
478435008277	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
478435008278	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
478435008279	purine monophosphate binding site [chemical binding]; other site
478435008280	dimer interface [polypeptide binding]; other site
478435008281	putative catalytic residues [active]
478435008282	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
478435008283	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
478435008284	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
478435008285	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
478435008286	active site
478435008287	substrate binding site [chemical binding]; other site
478435008288	cosubstrate binding site; other site
478435008289	catalytic site [active]
478435008290	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
478435008291	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435008292	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
478435008293	CoA binding domain; Region: CoA_binding; smart00881
478435008294	CoA-ligase; Region: Ligase_CoA; pfam00549
478435008295	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
478435008296	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
478435008297	CoA-ligase; Region: Ligase_CoA; pfam00549
478435008298	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
478435008299	Peptidase family M23; Region: Peptidase_M23; pfam01551
478435008300	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
478435008301	Part of AAA domain; Region: AAA_19; pfam13245
478435008302	Family description; Region: UvrD_C_2; pfam13538
478435008303	hypothetical protein; Provisional; Region: PRK07857
478435008304	Predicted esterase [General function prediction only]; Region: COG0627
478435008305	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
478435008306	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
478435008307	active site
478435008308	dimer interface [polypeptide binding]; other site
478435008309	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
478435008310	dimer interface [polypeptide binding]; other site
478435008311	active site
478435008312	short chain dehydrogenase; Provisional; Region: PRK08251
478435008313	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
478435008314	putative NAD(P) binding site [chemical binding]; other site
478435008315	active site
478435008316	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
478435008317	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
478435008318	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
478435008319	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435008320	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435008321	anti sigma factor interaction site; other site
478435008322	regulatory phosphorylation site [posttranslational modification]; other site
478435008323	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
478435008324	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435008325	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
478435008326	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
478435008327	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
478435008328	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
478435008329	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
478435008330	nucleotide binding site [chemical binding]; other site
478435008331	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
478435008332	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
478435008333	active site
478435008334	DNA binding site [nucleotide binding]
478435008335	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
478435008336	DNA binding site [nucleotide binding]
478435008337	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
478435008338	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
478435008339	putative DNA binding site [nucleotide binding]; other site
478435008340	putative homodimer interface [polypeptide binding]; other site
478435008341	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
478435008342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435008343	dimer interface [polypeptide binding]; other site
478435008344	conserved gate region; other site
478435008345	putative PBP binding loops; other site
478435008346	ABC-ATPase subunit interface; other site
478435008347	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
478435008348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435008349	dimer interface [polypeptide binding]; other site
478435008350	conserved gate region; other site
478435008351	putative PBP binding loops; other site
478435008352	ABC-ATPase subunit interface; other site
478435008353	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
478435008354	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271
478435008355	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
478435008356	Walker A/P-loop; other site
478435008357	ATP binding site [chemical binding]; other site
478435008358	Q-loop/lid; other site
478435008359	ABC transporter signature motif; other site
478435008360	Walker B; other site
478435008361	D-loop; other site
478435008362	H-loop/switch region; other site
478435008363	PBP superfamily domain; Region: PBP_like_2; cl17296
478435008364	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
478435008365	Catalytic domain of Protein Kinases; Region: PKc; cd00180
478435008366	active site
478435008367	ATP binding site [chemical binding]; other site
478435008368	substrate binding site [chemical binding]; other site
478435008369	activation loop (A-loop); other site
478435008370	Uncharacterized conserved protein [Function unknown]; Region: COG3391
478435008371	NHL repeat; Region: NHL; pfam01436
478435008372	NHL repeat; Region: NHL; pfam01436
478435008373	NHL repeat; Region: NHL; pfam01436
478435008374	NHL repeat; Region: NHL; pfam01436
478435008375	NHL repeat; Region: NHL; pfam01436
478435008376	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
478435008377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435008378	dimer interface [polypeptide binding]; other site
478435008379	conserved gate region; other site
478435008380	putative PBP binding loops; other site
478435008381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
478435008382	ABC-ATPase subunit interface; other site
478435008383	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
478435008384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435008385	dimer interface [polypeptide binding]; other site
478435008386	conserved gate region; other site
478435008387	putative PBP binding loops; other site
478435008388	ABC-ATPase subunit interface; other site
478435008389	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
478435008390	short chain dehydrogenase; Provisional; Region: PRK07814
478435008391	classical (c) SDRs; Region: SDR_c; cd05233
478435008392	NAD(P) binding site [chemical binding]; other site
478435008393	active site
478435008394	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
478435008395	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
478435008396	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
478435008397	manganese transport protein MntH; Reviewed; Region: PRK00701
478435008398	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
478435008399	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
478435008400	putative active site pocket [active]
478435008401	dimerization interface [polypeptide binding]; other site
478435008402	putative catalytic residue [active]
478435008403	Phage-related replication protein [General function prediction only]; Region: COG4195
478435008404	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435008405	Probable transposase; Region: OrfB_IS605; pfam01385
478435008406	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435008407	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
478435008408	catalytic residues [active]
478435008409	catalytic nucleophile [active]
478435008410	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435008411	MULE transposase domain; Region: MULE; pfam10551
478435008412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435008413	Coenzyme A binding pocket [chemical binding]; other site
478435008414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
478435008415	BCCT family transporter; Region: BCCT; pfam02028
478435008416	PE family; Region: PE; pfam00934
478435008417	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008418	PPE family; Region: PPE; pfam00823
478435008419	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
478435008420	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435008421	active site
478435008422	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
478435008423	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
478435008424	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
478435008425	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
478435008426	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435008427	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
478435008428	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435008429	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
478435008430	hydrophobic ligand binding site; other site
478435008431	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
478435008432	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
478435008433	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435008434	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435008435	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435008436	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435008437	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
478435008438	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
478435008439	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
478435008440	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
478435008441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435008442	substrate binding site [chemical binding]; other site
478435008443	oxyanion hole (OAH) forming residues; other site
478435008444	trimer interface [polypeptide binding]; other site
478435008445	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
478435008446	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
478435008447	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435008448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008449	active site
478435008450	phosphorylation site [posttranslational modification]
478435008451	intermolecular recognition site; other site
478435008452	dimerization interface [polypeptide binding]; other site
478435008453	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435008454	DNA binding site [nucleotide binding]
478435008455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435008456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435008457	dimerization interface [polypeptide binding]; other site
478435008458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435008459	dimer interface [polypeptide binding]; other site
478435008460	phosphorylation site [posttranslational modification]
478435008461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008462	Mg2+ binding site [ion binding]; other site
478435008463	G-X-G motif; other site
478435008464	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
478435008465	BON domain; Region: BON; pfam04972
478435008466	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
478435008467	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
478435008468	ligand binding site [chemical binding]; other site
478435008469	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
478435008470	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
478435008471	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435008472	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
478435008473	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
478435008474	dimer interface [polypeptide binding]; other site
478435008475	active site
478435008476	citrylCoA binding site [chemical binding]; other site
478435008477	NADH binding [chemical binding]; other site
478435008478	cationic pore residues; other site
478435008479	oxalacetate/citrate binding site [chemical binding]; other site
478435008480	coenzyme A binding site [chemical binding]; other site
478435008481	catalytic triad [active]
478435008482	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435008483	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435008484	AAA ATPase domain; Region: AAA_16; pfam13191
478435008485	Predicted ATPase [General function prediction only]; Region: COG3903
478435008486	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435008487	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435008488	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435008489	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435008490	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435008491	cyclase homology domain; Region: CHD; cd07302
478435008492	nucleotidyl binding site; other site
478435008493	metal binding site [ion binding]; metal-binding site
478435008494	dimer interface [polypeptide binding]; other site
478435008495	Predicted ATPase [General function prediction only]; Region: COG3903
478435008496	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435008497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435008498	DNA binding residues [nucleotide binding]
478435008499	dimerization interface [polypeptide binding]; other site
478435008500	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
478435008501	dimer interface [polypeptide binding]; other site
478435008502	Citrate synthase; Region: Citrate_synt; pfam00285
478435008503	active site
478435008504	citrylCoA binding site [chemical binding]; other site
478435008505	oxalacetate/citrate binding site [chemical binding]; other site
478435008506	coenzyme A binding site [chemical binding]; other site
478435008507	catalytic triad [active]
478435008508	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
478435008509	putative catalytic site [active]
478435008510	putative phosphate binding site [ion binding]; other site
478435008511	putative metal binding site [ion binding]; other site
478435008512	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
478435008513	putative dimer interface [polypeptide binding]; other site
478435008514	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
478435008515	Ferredoxin [Energy production and conversion]; Region: COG1146
478435008516	4Fe-4S binding domain; Region: Fer4; pfam00037
478435008517	ferredoxin-NADP+ reductase; Region: PLN02852
478435008518	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435008519	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
478435008520	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
478435008521	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435008522	catalytic residue [active]
478435008523	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
478435008524	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
478435008525	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
478435008526	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
478435008527	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
478435008528	MarR family; Region: MarR; pfam01047
478435008529	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
478435008530	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
478435008531	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008532	PPE family; Region: PPE; pfam00823
478435008533	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435008534	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435008535	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
478435008536	H+ Antiporter protein; Region: 2A0121; TIGR00900
478435008537	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
478435008538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
478435008539	FIST N domain; Region: FIST; pfam08495
478435008540	FIST C domain; Region: FIST_C; pfam10442
478435008541	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435008542	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435008543	active site
478435008544	PE family; Region: PE; pfam00934
478435008545	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
478435008546	DNA-binding site [nucleotide binding]; DNA binding site
478435008547	RNA-binding motif; other site
478435008548	hypothetical protein; Provisional; Region: PRK11770
478435008549	Domain of unknown function (DUF307); Region: DUF307; pfam03733
478435008550	Domain of unknown function (DUF307); Region: DUF307; pfam03733
478435008551	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
478435008552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435008553	FeS/SAM binding site; other site
478435008554	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
478435008555	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
478435008556	MoaE interaction surface [polypeptide binding]; other site
478435008557	MoeB interaction surface [polypeptide binding]; other site
478435008558	thiocarboxylated glycine; other site
478435008559	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
478435008560	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
478435008561	MoaE homodimer interface [polypeptide binding]; other site
478435008562	MoaD interaction [polypeptide binding]; other site
478435008563	active site residues [active]
478435008564	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
478435008565	MPT binding site; other site
478435008566	trimer interface [polypeptide binding]; other site
478435008567	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
478435008568	trimer interface [polypeptide binding]; other site
478435008569	dimer interface [polypeptide binding]; other site
478435008570	putative active site [active]
478435008571	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
478435008572	WYL domain; Region: WYL; pfam13280
478435008573	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
478435008574	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
478435008575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435008576	ATP binding site [chemical binding]; other site
478435008577	putative Mg++ binding site [ion binding]; other site
478435008578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435008579	nucleotide binding region [chemical binding]; other site
478435008580	ATP-binding site [chemical binding]; other site
478435008581	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
478435008582	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435008583	substrate binding site [chemical binding]; other site
478435008584	oxyanion hole (OAH) forming residues; other site
478435008585	trimer interface [polypeptide binding]; other site
478435008586	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
478435008587	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
478435008588	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
478435008589	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435008590	dimer interface [polypeptide binding]; other site
478435008591	active site
478435008592	aminotransferase; Validated; Region: PRK07777
478435008593	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435008594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435008595	homodimer interface [polypeptide binding]; other site
478435008596	catalytic residue [active]
478435008597	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
478435008598	putative hydrophobic ligand binding site [chemical binding]; other site
478435008599	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
478435008600	putative hydrophobic ligand binding site [chemical binding]; other site
478435008601	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
478435008602	CoA-transferase family III; Region: CoA_transf_3; pfam02515
478435008603	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
478435008604	putative hydrophobic ligand binding site [chemical binding]; other site
478435008605	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
478435008606	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
478435008607	dimer interface [polypeptide binding]; other site
478435008608	PYR/PP interface [polypeptide binding]; other site
478435008609	TPP binding site [chemical binding]; other site
478435008610	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
478435008611	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
478435008612	TPP-binding site [chemical binding]; other site
478435008613	dimer interface [polypeptide binding]; other site
478435008614	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435008615	short chain dehydrogenase; Provisional; Region: PRK05876
478435008616	classical (c) SDRs; Region: SDR_c; cd05233
478435008617	NAD(P) binding site [chemical binding]; other site
478435008618	active site
478435008619	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
478435008620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435008621	multidrug resistance protein MdtH; Provisional; Region: PRK11646
478435008622	putative substrate translocation pore; other site
478435008623	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
478435008624	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
478435008625	dimer interface [polypeptide binding]; other site
478435008626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435008627	catalytic residue [active]
478435008628	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
478435008629	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
478435008630	Multicopper oxidase; Region: Cu-oxidase; pfam00394
478435008631	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
478435008632	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
478435008633	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
478435008634	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435008635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008636	active site
478435008637	phosphorylation site [posttranslational modification]
478435008638	intermolecular recognition site; other site
478435008639	dimerization interface [polypeptide binding]; other site
478435008640	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435008641	DNA binding residues [nucleotide binding]
478435008642	dimerization interface [polypeptide binding]; other site
478435008643	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
478435008644	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
478435008645	tetramer interface [polypeptide binding]; other site
478435008646	TPP-binding site [chemical binding]; other site
478435008647	heterodimer interface [polypeptide binding]; other site
478435008648	phosphorylation loop region [posttranslational modification]
478435008649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435008650	putative substrate translocation pore; other site
478435008651	Major Facilitator Superfamily; Region: MFS_1; pfam07690
478435008652	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
478435008653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435008654	S-adenosylmethionine binding site [chemical binding]; other site
478435008655	D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427
478435008656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
478435008657	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
478435008658	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
478435008659	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435008660	Transposase; Region: HTH_Tnp_1; cl17663
478435008661	putative transposase OrfB; Reviewed; Region: PHA02517
478435008662	HTH-like domain; Region: HTH_21; pfam13276
478435008663	Integrase core domain; Region: rve; pfam00665
478435008664	Integrase core domain; Region: rve_3; pfam13683
478435008665	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
478435008666	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
478435008667	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
478435008668	nucleoside/Zn binding site; other site
478435008669	dimer interface [polypeptide binding]; other site
478435008670	catalytic motif [active]
478435008671	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435008672	MULE transposase domain; Region: MULE; pfam10551
478435008673	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
478435008674	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
478435008675	ATP binding site [chemical binding]; other site
478435008676	substrate interface [chemical binding]; other site
478435008677	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
478435008678	active site residue [active]
478435008679	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
478435008680	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
478435008681	active site residue [active]
478435008682	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
478435008683	active site residue [active]
478435008684	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
478435008685	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
478435008686	MoaE homodimer interface [polypeptide binding]; other site
478435008687	MoaD interaction [polypeptide binding]; other site
478435008688	active site residues [active]
478435008689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435008690	S-adenosylmethionine binding site [chemical binding]; other site
478435008691	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435008692	Cytochrome P450; Region: p450; cl12078
478435008693	putative transposase OrfB; Reviewed; Region: PHA02517
478435008694	HTH-like domain; Region: HTH_21; pfam13276
478435008695	Integrase core domain; Region: rve; pfam00665
478435008696	Integrase core domain; Region: rve_3; pfam13683
478435008697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435008698	Transposase; Region: HTH_Tnp_1; cl17663
478435008699	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
478435008700	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
478435008701	DNA binding site [nucleotide binding]
478435008702	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008703	PPE family; Region: PPE; pfam00823
478435008704	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
478435008705	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
478435008706	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435008707	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435008708	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
478435008709	dimer interface [polypeptide binding]; other site
478435008710	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
478435008711	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
478435008712	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
478435008713	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
478435008714	Histidine kinase; Region: HisKA_3; pfam07730
478435008715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008716	ATP binding site [chemical binding]; other site
478435008717	Mg2+ binding site [ion binding]; other site
478435008718	G-X-G motif; other site
478435008719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
478435008720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008721	active site
478435008722	phosphorylation site [posttranslational modification]
478435008723	intermolecular recognition site; other site
478435008724	dimerization interface [polypeptide binding]; other site
478435008725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
478435008726	DNA binding residues [nucleotide binding]
478435008727	dimerization interface [polypeptide binding]; other site
478435008728	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
478435008729	Ligand Binding Site [chemical binding]; other site
478435008730	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008731	PPE family; Region: PPE; pfam00823
478435008732	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008733	PPE family; Region: PPE; pfam00823
478435008734	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435008735	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
478435008736	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
478435008737	active site
478435008738	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
478435008739	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435008740	FeS/SAM binding site; other site
478435008741	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435008742	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435008743	active site
478435008744	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435008745	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435008746	active site
478435008747	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
478435008748	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
478435008749	NAD(P) binding site [chemical binding]; other site
478435008750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435008751	active site
478435008752	phosphorylation site [posttranslational modification]
478435008753	intermolecular recognition site; other site
478435008754	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008755	PPE family; Region: PPE; pfam00823
478435008756	NADH dehydrogenase subunit A; Validated; Region: PRK07928
478435008757	NADH dehydrogenase subunit B; Validated; Region: PRK06411
478435008758	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
478435008759	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
478435008760	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
478435008761	NADH dehydrogenase subunit D; Validated; Region: PRK06075
478435008762	NADH dehydrogenase subunit E; Validated; Region: PRK07539
478435008763	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
478435008764	putative dimer interface [polypeptide binding]; other site
478435008765	[2Fe-2S] cluster binding site [ion binding]; other site
478435008766	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
478435008767	SLBB domain; Region: SLBB; pfam10531
478435008768	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
478435008769	NADH dehydrogenase subunit G; Validated; Region: PRK07860
478435008770	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435008771	catalytic loop [active]
478435008772	iron binding site [ion binding]; other site
478435008773	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
478435008774	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
478435008775	[4Fe-4S] binding site [ion binding]; other site
478435008776	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
478435008777	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
478435008778	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
478435008779	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
478435008780	4Fe-4S binding domain; Region: Fer4; pfam00037
478435008781	4Fe-4S binding domain; Region: Fer4; pfam00037
478435008782	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
478435008783	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
478435008784	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
478435008785	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
478435008786	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
478435008787	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
478435008788	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
478435008789	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
478435008790	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
478435008791	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435008792	PPE family; Region: PPE; pfam00823
478435008793	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
478435008794	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435008795	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
478435008796	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
478435008797	[2Fe-2S] cluster binding site [ion binding]; other site
478435008798	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
478435008799	putative alpha subunit interface [polypeptide binding]; other site
478435008800	putative active site [active]
478435008801	putative substrate binding site [chemical binding]; other site
478435008802	Fe binding site [ion binding]; other site
478435008803	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
478435008804	Protein of unknown function DUF58; Region: DUF58; pfam01882
478435008805	MoxR-like ATPases [General function prediction only]; Region: COG0714
478435008806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435008807	Walker A motif; other site
478435008808	ATP binding site [chemical binding]; other site
478435008809	Walker B motif; other site
478435008810	arginine finger; other site
478435008811	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
478435008812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435008813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435008814	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
478435008815	putative active site [active]
478435008816	putative substrate binding site [chemical binding]; other site
478435008817	ATP binding site [chemical binding]; other site
478435008818	Phosphotransferase enzyme family; Region: APH; pfam01636
478435008819	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
478435008820	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435008821	hydroxyglutarate oxidase; Provisional; Region: PRK11728
478435008822	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435008823	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435008824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435008825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435008826	short chain dehydrogenase; Validated; Region: PRK08264
478435008827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435008828	NAD(P) binding site [chemical binding]; other site
478435008829	active site
478435008830	amidase; Provisional; Region: PRK06170
478435008831	Amidase; Region: Amidase; pfam01425
478435008832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435008833	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435008834	TAP-like protein; Region: Abhydrolase_4; pfam08386
478435008835	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435008836	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
478435008837	AAA domain; Region: AAA_14; pfam13173
478435008838	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
478435008839	putative active site [active]
478435008840	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435008841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
478435008842	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
478435008843	non-specific DNA binding site [nucleotide binding]; other site
478435008844	salt bridge; other site
478435008845	sequence-specific DNA binding site [nucleotide binding]; other site
478435008846	RES domain; Region: RES; pfam08808
478435008847	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
478435008848	Helix-turn-helix domain; Region: HTH_38; pfam13936
478435008849	Integrase core domain; Region: rve; pfam00665
478435008850	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
478435008851	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435008852	hypothetical protein; Validated; Region: PRK00068
478435008853	Uncharacterized conserved protein [Function unknown]; Region: COG1615
478435008854	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
478435008855	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
478435008856	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
478435008857	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
478435008858	Uncharacterized conserved protein [Function unknown]; Region: COG5282
478435008859	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
478435008860	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
478435008861	ABC1 family; Region: ABC1; pfam03109
478435008862	Phosphotransferase enzyme family; Region: APH; pfam01636
478435008863	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
478435008864	active site
478435008865	ATP binding site [chemical binding]; other site
478435008866	Transcription factor WhiB; Region: Whib; pfam02467
478435008867	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
478435008868	Part of AAA domain; Region: AAA_19; pfam13245
478435008869	Family description; Region: UvrD_C_2; pfam13538
478435008870	HRDC domain; Region: HRDC; pfam00570
478435008871	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
478435008872	catalytic residues [active]
478435008873	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
478435008874	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
478435008875	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
478435008876	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
478435008877	putative NADH binding site [chemical binding]; other site
478435008878	putative active site [active]
478435008879	nudix motif; other site
478435008880	putative metal binding site [ion binding]; other site
478435008881	Ion channel; Region: Ion_trans_2; pfam07885
478435008882	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
478435008883	TrkA-N domain; Region: TrkA_N; pfam02254
478435008884	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
478435008885	Part of AAA domain; Region: AAA_19; pfam13245
478435008886	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
478435008887	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
478435008888	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
478435008889	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
478435008890	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435008891	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435008892	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
478435008893	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
478435008894	active site
478435008895	DNA binding site [nucleotide binding]
478435008896	TIGR02569 family protein; Region: TIGR02569_actnb
478435008897	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
478435008898	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
478435008899	ATP binding site [chemical binding]; other site
478435008900	substrate interface [chemical binding]; other site
478435008901	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
478435008902	active site residue [active]
478435008903	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
478435008904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435008905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435008906	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
478435008907	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
478435008908	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
478435008909	DEAD-like helicases superfamily; Region: DEXDc; smart00487
478435008910	ATP binding site [chemical binding]; other site
478435008911	Mg++ binding site [ion binding]; other site
478435008912	motif III; other site
478435008913	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435008914	nucleotide binding region [chemical binding]; other site
478435008915	ATP-binding site [chemical binding]; other site
478435008916	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
478435008917	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435008918	P-loop; other site
478435008919	Magnesium ion binding site [ion binding]; other site
478435008920	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435008921	Magnesium ion binding site [ion binding]; other site
478435008922	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435008923	catalytic core [active]
478435008924	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
478435008925	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
478435008926	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
478435008927	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
478435008928	Transcription factor WhiB; Region: Whib; pfam02467
478435008929	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
478435008930	PAS domain S-box; Region: sensory_box; TIGR00229
478435008931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
478435008932	Histidine kinase; Region: HisKA_2; pfam07568
478435008933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435008934	ATP binding site [chemical binding]; other site
478435008935	Mg2+ binding site [ion binding]; other site
478435008936	G-X-G motif; other site
478435008937	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
478435008938	carboxyltransferase (CT) interaction site; other site
478435008939	biotinylation site [posttranslational modification]; other site
478435008940	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
478435008941	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
478435008942	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435008943	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435008944	DNA binding residues [nucleotide binding]
478435008945	short chain dehydrogenase; Provisional; Region: PRK08278
478435008946	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
478435008947	NAD(P) binding site [chemical binding]; other site
478435008948	homodimer interface [polypeptide binding]; other site
478435008949	active site
478435008950	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
478435008951	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
478435008952	putative deacylase active site [active]
478435008953	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
478435008954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
478435008955	Coenzyme A binding pocket [chemical binding]; other site
478435008956	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
478435008957	Phosphotransferase enzyme family; Region: APH; pfam01636
478435008958	putative active site [active]
478435008959	putative substrate binding site [chemical binding]; other site
478435008960	ATP binding site [chemical binding]; other site
478435008961	Uncharacterized conserved protein [Function unknown]; Region: COG2135
478435008962	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
478435008963	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
478435008964	hinge; other site
478435008965	active site
478435008966	Predicted GTPases [General function prediction only]; Region: COG1162
478435008967	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
478435008968	GTPase/Zn-binding domain interface [polypeptide binding]; other site
478435008969	GTP/Mg2+ binding site [chemical binding]; other site
478435008970	G4 box; other site
478435008971	G5 box; other site
478435008972	G1 box; other site
478435008973	Switch I region; other site
478435008974	G2 box; other site
478435008975	G3 box; other site
478435008976	Switch II region; other site
478435008977	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
478435008978	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
478435008979	putative di-iron ligands [ion binding]; other site
478435008980	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
478435008981	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
478435008982	FAD binding pocket [chemical binding]; other site
478435008983	FAD binding motif [chemical binding]; other site
478435008984	phosphate binding motif [ion binding]; other site
478435008985	beta-alpha-beta structure motif; other site
478435008986	NAD binding pocket [chemical binding]; other site
478435008987	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435008988	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
478435008989	catalytic loop [active]
478435008990	iron binding site [ion binding]; other site
478435008991	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
478435008992	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435008993	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435008994	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
478435008995	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
478435008996	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
478435008997	TrkA-C domain; Region: TrkA_C; pfam02080
478435008998	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
478435008999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435009000	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435009001	putative substrate translocation pore; other site
478435009002	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435009003	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435009004	ligand binding site [chemical binding]; other site
478435009005	flexible hinge region; other site
478435009006	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
478435009007	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
478435009008	nucleophile elbow; other site
478435009009	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
478435009010	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
478435009011	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
478435009012	30S subunit binding site; other site
478435009013	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
478435009014	active site
478435009015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
478435009016	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
478435009017	lipoprotein LpqB; Provisional; Region: PRK13616
478435009018	Sporulation and spore germination; Region: Germane; pfam10646
478435009019	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
478435009020	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435009021	dimerization interface [polypeptide binding]; other site
478435009022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435009023	dimer interface [polypeptide binding]; other site
478435009024	phosphorylation site [posttranslational modification]
478435009025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435009026	ATP binding site [chemical binding]; other site
478435009027	Mg2+ binding site [ion binding]; other site
478435009028	G-X-G motif; other site
478435009029	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435009030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435009031	active site
478435009032	phosphorylation site [posttranslational modification]
478435009033	intermolecular recognition site; other site
478435009034	dimerization interface [polypeptide binding]; other site
478435009035	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435009036	DNA binding site [nucleotide binding]
478435009037	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
478435009038	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
478435009039	TMP-binding site; other site
478435009040	ATP-binding site [chemical binding]; other site
478435009041	Adenosylhomocysteinase; Provisional; Region: PTZ00075
478435009042	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
478435009043	homotetramer interface [polypeptide binding]; other site
478435009044	ligand binding site [chemical binding]; other site
478435009045	catalytic site [active]
478435009046	NAD binding site [chemical binding]; other site
478435009047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435009048	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
478435009049	Rubredoxin [Energy production and conversion]; Region: COG1773
478435009050	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
478435009051	iron binding site [ion binding]; other site
478435009052	Rubredoxin [Energy production and conversion]; Region: COG1773
478435009053	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
478435009054	iron binding site [ion binding]; other site
478435009055	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
478435009056	Fatty acid desaturase; Region: FA_desaturase; pfam00487
478435009057	Di-iron ligands [ion binding]; other site
478435009058	amino acid transporter; Region: 2A0306; TIGR00909
478435009059	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
478435009060	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
478435009061	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
478435009062	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
478435009063	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
478435009064	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
478435009065	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
478435009066	active site
478435009067	substrate binding site [chemical binding]; other site
478435009068	metal binding site [ion binding]; metal-binding site
478435009069	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
478435009070	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
478435009071	Transcription factor WhiB; Region: Whib; pfam02467
478435009072	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
478435009073	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
478435009074	phosphate binding site [ion binding]; other site
478435009075	dimer interface [polypeptide binding]; other site
478435009076	substrate binding site [chemical binding]; other site
478435009077	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
478435009078	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
478435009079	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
478435009080	putative FMN binding site [chemical binding]; other site
478435009081	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
478435009082	Methyltransferase domain; Region: Methyltransf_26; pfam13659
478435009083	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
478435009084	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
478435009085	active site
478435009086	Substrate binding site; other site
478435009087	Mg++ binding site; other site
478435009088	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
478435009089	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
478435009090	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
478435009091	Probable Catalytic site; other site
478435009092	metal-binding site
478435009093	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
478435009094	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
478435009095	NADP binding site [chemical binding]; other site
478435009096	active site
478435009097	putative substrate binding site [chemical binding]; other site
478435009098	Transcriptional regulator [Transcription]; Region: LytR; COG1316
478435009099	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
478435009100	TIGR03089 family protein; Region: TIGR03089
478435009101	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
478435009102	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
478435009103	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435009104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
478435009105	active site
478435009106	motif I; other site
478435009107	motif II; other site
478435009108	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
478435009109	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
478435009110	CoA-transferase family III; Region: CoA_transf_3; pfam02515
478435009111	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
478435009112	Sulfate transporter family; Region: Sulfate_transp; pfam00916
478435009113	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
478435009114	active site clefts [active]
478435009115	zinc binding site [ion binding]; other site
478435009116	dimer interface [polypeptide binding]; other site
478435009117	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009118	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
478435009119	FAD binding site [chemical binding]; other site
478435009120	homotetramer interface [polypeptide binding]; other site
478435009121	substrate binding pocket [chemical binding]; other site
478435009122	catalytic base [active]
478435009123	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
478435009124	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
478435009125	ATP-grasp domain; Region: ATP-grasp; pfam02222
478435009126	Predicted membrane protein [Function unknown]; Region: COG2246
478435009127	GtrA-like protein; Region: GtrA; pfam04138
478435009128	Bacterial PH domain; Region: DUF304; pfam03703
478435009129	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
478435009130	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
478435009131	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
478435009132	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
478435009133	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
478435009134	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
478435009135	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
478435009136	Maf-like protein; Region: Maf; pfam02545
478435009137	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
478435009138	active site
478435009139	dimer interface [polypeptide binding]; other site
478435009140	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
478435009141	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
478435009142	active site residue [active]
478435009143	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
478435009144	active site residue [active]
478435009145	Fe-S metabolism associated domain; Region: SufE; pfam02657
478435009146	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
478435009147	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
478435009148	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
478435009149	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
478435009150	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
478435009151	carboxyltransferase (CT) interaction site; other site
478435009152	biotinylation site [posttranslational modification]; other site
478435009153	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
478435009154	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435009155	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
478435009156	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
478435009157	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
478435009158	L-lysine aminotransferase; Provisional; Region: PRK08297
478435009159	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
478435009160	inhibitor-cofactor binding pocket; inhibition site
478435009161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009162	catalytic residue [active]
478435009163	putative DNA binding site [nucleotide binding]; other site
478435009164	dimerization interface [polypeptide binding]; other site
478435009165	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
478435009166	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
478435009167	putative Zn2+ binding site [ion binding]; other site
478435009168	AsnC family; Region: AsnC_trans_reg; pfam01037
478435009169	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
478435009170	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
478435009171	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
478435009172	tetrameric interface [polypeptide binding]; other site
478435009173	NAD binding site [chemical binding]; other site
478435009174	catalytic residues [active]
478435009175	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
478435009176	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435009177	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435009178	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435009179	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
478435009180	ATP binding site [chemical binding]; other site
478435009181	putative Mg++ binding site [ion binding]; other site
478435009182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435009183	nucleotide binding region [chemical binding]; other site
478435009184	ATP-binding site [chemical binding]; other site
478435009185	DEAD/H associated; Region: DEAD_assoc; pfam08494
478435009186	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
478435009187	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
478435009188	putative DNA binding site [nucleotide binding]; other site
478435009189	catalytic residue [active]
478435009190	putative H2TH interface [polypeptide binding]; other site
478435009191	putative catalytic residues [active]
478435009192	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
478435009193	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
478435009194	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
478435009195	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
478435009196	Sulfatase; Region: Sulfatase; pfam00884
478435009197	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
478435009198	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
478435009199	probable active site [active]
478435009200	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
478435009201	PhoU domain; Region: PhoU; pfam01895
478435009202	PhoU domain; Region: PhoU; pfam01895
478435009203	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
478435009204	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
478435009205	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435009206	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
478435009207	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
478435009208	putative active site pocket [active]
478435009209	dimerization interface [polypeptide binding]; other site
478435009210	putative catalytic residue [active]
478435009211	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
478435009212	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
478435009213	metal binding site [ion binding]; metal-binding site
478435009214	putative dimer interface [polypeptide binding]; other site
478435009215	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
478435009216	amidohydrolase; Region: amidohydrolases; TIGR01891
478435009217	metal binding site [ion binding]; metal-binding site
478435009218	purine nucleoside phosphorylase; Provisional; Region: PRK08202
478435009219	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
478435009220	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
478435009221	active site
478435009222	substrate binding site [chemical binding]; other site
478435009223	metal binding site [ion binding]; metal-binding site
478435009224	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435009225	active site
478435009226	Phosphoesterase family; Region: Phosphoesterase; pfam04185
478435009227	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435009228	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
478435009229	adenosine deaminase; Provisional; Region: PRK09358
478435009230	active site
478435009231	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
478435009232	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
478435009233	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
478435009234	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
478435009235	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
478435009236	active site
478435009237	catalytic motif [active]
478435009238	Zn binding site [ion binding]; other site
478435009239	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
478435009240	putative Iron-sulfur protein interface [polypeptide binding]; other site
478435009241	putative proximal heme binding site [chemical binding]; other site
478435009242	putative SdhD-like interface [polypeptide binding]; other site
478435009243	putative distal heme binding site [chemical binding]; other site
478435009244	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
478435009245	putative Iron-sulfur protein interface [polypeptide binding]; other site
478435009246	putative proximal heme binding site [chemical binding]; other site
478435009247	putative SdhC-like subunit interface [polypeptide binding]; other site
478435009248	putative distal heme binding site [chemical binding]; other site
478435009249	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
478435009250	L-aspartate oxidase; Provisional; Region: PRK06175
478435009251	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
478435009252	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
478435009253	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
478435009254	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435009255	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
478435009256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435009257	S-adenosylmethionine binding site [chemical binding]; other site
478435009258	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
478435009259	MoaE interaction surface [polypeptide binding]; other site
478435009260	MoeB interaction surface [polypeptide binding]; other site
478435009261	thiocarboxylated glycine; other site
478435009262	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
478435009263	MoaE homodimer interface [polypeptide binding]; other site
478435009264	MoaD interaction [polypeptide binding]; other site
478435009265	active site residues [active]
478435009266	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
478435009267	trimer interface [polypeptide binding]; other site
478435009268	dimer interface [polypeptide binding]; other site
478435009269	putative active site [active]
478435009270	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
478435009271	aromatic arch; other site
478435009272	DCoH dimer interaction site [polypeptide binding]; other site
478435009273	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
478435009274	DCoH tetramer interaction site [polypeptide binding]; other site
478435009275	substrate binding site [chemical binding]; other site
478435009276	putative transposase OrfB; Reviewed; Region: PHA02517
478435009277	HTH-like domain; Region: HTH_21; pfam13276
478435009278	Integrase core domain; Region: rve; pfam00665
478435009279	Integrase core domain; Region: rve_3; pfam13683
478435009280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435009281	Transposase; Region: HTH_Tnp_1; cl17663
478435009282	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435009283	hypothetical protein; Provisional; Region: PRK06541
478435009284	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
478435009285	inhibitor-cofactor binding pocket; inhibition site
478435009286	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009287	catalytic residue [active]
478435009288	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
478435009289	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
478435009290	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
478435009291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435009292	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
478435009293	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
478435009294	active site
478435009295	dimer interface [polypeptide binding]; other site
478435009296	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435009297	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
478435009298	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
478435009299	DNA binding residues [nucleotide binding]
478435009300	dimer interface [polypeptide binding]; other site
478435009301	metal binding site [ion binding]; metal-binding site
478435009302	inner membrane protein YhjD; Region: TIGR00766
478435009303	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
478435009304	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
478435009305	active site
478435009306	HIGH motif; other site
478435009307	dimer interface [polypeptide binding]; other site
478435009308	KMSKS motif; other site
478435009309	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
478435009310	isocitrate dehydrogenase; Validated; Region: PRK08299
478435009311	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
478435009312	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
478435009313	homodimer interface [polypeptide binding]; other site
478435009314	substrate-cofactor binding pocket; other site
478435009315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009316	catalytic residue [active]
478435009317	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
478435009318	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
478435009319	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435009320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435009321	S-adenosylmethionine binding site [chemical binding]; other site
478435009322	PPE family; Region: PPE; pfam00823
478435009323	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009324	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009325	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009326	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009327	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009328	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009329	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009330	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009331	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009332	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009333	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009334	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009335	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009336	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009337	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009338	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009339	PE family; Region: PE; pfam00934
478435009340	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
478435009341	PPE family; Region: PPE; pfam00823
478435009342	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009343	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009344	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009345	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009346	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009347	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009348	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009349	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009350	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009351	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009352	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009353	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435009354	Transposase; Region: DDE_Tnp_ISL3; pfam01610
478435009355	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009356	PPE family; Region: PPE; pfam00823
478435009357	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009358	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009359	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009360	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009361	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009362	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009363	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009364	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009365	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009366	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009367	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009368	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009369	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009370	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009371	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009372	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009373	Berberine and berberine like; Region: BBE; pfam08031
478435009374	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435009375	Protein of unknown function (DUF732); Region: DUF732; pfam05305
478435009376	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
478435009377	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
478435009378	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
478435009379	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
478435009380	homodimer interface [polypeptide binding]; other site
478435009381	NADP binding site [chemical binding]; other site
478435009382	substrate binding site [chemical binding]; other site
478435009383	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
478435009384	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
478435009385	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
478435009386	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
478435009387	active site
478435009388	FMN binding site [chemical binding]; other site
478435009389	substrate binding site [chemical binding]; other site
478435009390	putative catalytic residue [active]
478435009391	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435009392	phosphate binding site [ion binding]; other site
478435009393	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435009394	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
478435009395	phosphopeptide binding site; other site
478435009396	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
478435009397	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
478435009398	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
478435009399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
478435009400	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
478435009401	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
478435009402	G1 box; other site
478435009403	GTP/Mg2+ binding site [chemical binding]; other site
478435009404	G2 box; other site
478435009405	Switch I region; other site
478435009406	G3 box; other site
478435009407	Switch II region; other site
478435009408	G4 box; other site
478435009409	G5 box; other site
478435009410	Protein of unknown function (DUF742); Region: DUF742; pfam05331
478435009411	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
478435009412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435009413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435009414	ATP binding site [chemical binding]; other site
478435009415	Mg2+ binding site [ion binding]; other site
478435009416	G-X-G motif; other site
478435009417	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
478435009418	PE family; Region: PE; pfam00934
478435009419	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
478435009420	FMN binding site [chemical binding]; other site
478435009421	dimer interface [polypeptide binding]; other site
478435009422	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
478435009423	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
478435009424	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
478435009425	active site
478435009426	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
478435009427	generic binding surface II; other site
478435009428	generic binding surface I; other site
478435009429	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435009430	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435009431	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
478435009432	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
478435009433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435009434	active site
478435009435	motif I; other site
478435009436	motif II; other site
478435009437	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435009438	substrate binding site [chemical binding]; other site
478435009439	oxyanion hole (OAH) forming residues; other site
478435009440	trimer interface [polypeptide binding]; other site
478435009441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
478435009442	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
478435009443	Amidase; Region: Amidase; pfam01425
478435009444	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
478435009445	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435009446	motif II; other site
478435009447	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
478435009448	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
478435009449	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
478435009450	TPP-binding site [chemical binding]; other site
478435009451	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
478435009452	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
478435009453	PYR/PP interface [polypeptide binding]; other site
478435009454	dimer interface [polypeptide binding]; other site
478435009455	TPP binding site [chemical binding]; other site
478435009456	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
478435009457	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
478435009458	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
478435009459	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
478435009460	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
478435009461	substrate binding pocket [chemical binding]; other site
478435009462	chain length determination region; other site
478435009463	substrate-Mg2+ binding site; other site
478435009464	catalytic residues [active]
478435009465	aspartate-rich region 1; other site
478435009466	active site lid residues [active]
478435009467	aspartate-rich region 2; other site
478435009468	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
478435009469	putative active site [active]
478435009470	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435009471	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
478435009472	Transposase domain (DUF772); Region: DUF772; pfam05598
478435009473	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
478435009474	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
478435009475	PE family; Region: PE; pfam00934
478435009476	enoyl-CoA hydratase; Region: PLN02864
478435009477	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
478435009478	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
478435009479	dimer interaction site [polypeptide binding]; other site
478435009480	substrate-binding tunnel; other site
478435009481	active site
478435009482	catalytic site [active]
478435009483	substrate binding site [chemical binding]; other site
478435009484	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435009485	short chain dehydrogenase; Provisional; Region: PRK07201
478435009486	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
478435009487	putative NAD(P) binding site [chemical binding]; other site
478435009488	active site
478435009489	putative substrate binding site [chemical binding]; other site
478435009490	classical (c) SDRs; Region: SDR_c; cd05233
478435009491	NAD(P) binding site [chemical binding]; other site
478435009492	active site
478435009493	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435009494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435009495	S-adenosylmethionine binding site [chemical binding]; other site
478435009496	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
478435009497	active site
478435009498	DNA Polymerase Y-family; Region: PolY_like; cd03468
478435009499	DNA binding site [nucleotide binding]
478435009500	GMP synthase; Reviewed; Region: guaA; PRK00074
478435009501	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
478435009502	AMP/PPi binding site [chemical binding]; other site
478435009503	candidate oxyanion hole; other site
478435009504	catalytic triad [active]
478435009505	potential glutamine specificity residues [chemical binding]; other site
478435009506	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
478435009507	ATP Binding subdomain [chemical binding]; other site
478435009508	Ligand Binding sites [chemical binding]; other site
478435009509	Dimerization subdomain; other site
478435009510	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
478435009511	active site lid residues [active]
478435009512	substrate binding pocket [chemical binding]; other site
478435009513	catalytic residues [active]
478435009514	substrate-Mg2+ binding site; other site
478435009515	aspartate-rich region 1; other site
478435009516	aspartate-rich region 2; other site
478435009517	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
478435009518	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
478435009519	substrate binding pocket [chemical binding]; other site
478435009520	chain length determination region; other site
478435009521	substrate-Mg2+ binding site; other site
478435009522	catalytic residues [active]
478435009523	aspartate-rich region 1; other site
478435009524	active site lid residues [active]
478435009525	aspartate-rich region 2; other site
478435009526	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435009527	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435009528	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
478435009529	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
478435009530	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
478435009531	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
478435009532	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
478435009533	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
478435009534	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
478435009535	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
478435009536	inhibitor-cofactor binding pocket; inhibition site
478435009537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009538	catalytic residue [active]
478435009539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
478435009540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435009541	hypothetical protein; Provisional; Region: PRK07579
478435009542	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
478435009543	active site
478435009544	cosubstrate binding site; other site
478435009545	substrate binding site [chemical binding]; other site
478435009546	catalytic site [active]
478435009547	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435009548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435009549	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
478435009550	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
478435009551	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
478435009552	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
478435009553	putative active site [active]
478435009554	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
478435009555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435009556	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
478435009557	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
478435009558	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435009559	phosphate binding site [ion binding]; other site
478435009560	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
478435009561	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
478435009562	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
478435009563	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
478435009564	active site
478435009565	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
478435009566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435009567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435009568	DNA binding residues [nucleotide binding]
478435009569	Transcription factor WhiB; Region: Whib; pfam02467
478435009570	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
478435009571	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
478435009572	ring oligomerisation interface [polypeptide binding]; other site
478435009573	ATP/Mg binding site [chemical binding]; other site
478435009574	stacking interactions; other site
478435009575	hinge regions; other site
478435009576	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
478435009577	oligomerisation interface [polypeptide binding]; other site
478435009578	mobile loop; other site
478435009579	roof hairpin; other site
478435009580	UGMP family protein; Validated; Region: PRK09604
478435009581	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
478435009582	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
478435009583	Coenzyme A binding pocket [chemical binding]; other site
478435009584	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
478435009585	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
478435009586	alanine racemase; Reviewed; Region: alr; PRK00053
478435009587	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
478435009588	active site
478435009589	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
478435009590	dimer interface [polypeptide binding]; other site
478435009591	substrate binding site [chemical binding]; other site
478435009592	catalytic residues [active]
478435009593	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009594	PPE family; Region: PPE; pfam00823
478435009595	Integrase core domain; Region: rve; pfam00665
478435009596	Integrase core domain; Region: rve_3; pfam13683
478435009597	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435009598	MULE transposase domain; Region: MULE; pfam10551
478435009599	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
478435009600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009601	catalytic residue [active]
478435009602	Uncharacterized conserved protein [Function unknown]; Region: COG0062
478435009603	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
478435009604	putative substrate binding site [chemical binding]; other site
478435009605	putative ATP binding site [chemical binding]; other site
478435009606	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
478435009607	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
478435009608	glutaminase active site [active]
478435009609	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
478435009610	dimer interface [polypeptide binding]; other site
478435009611	active site
478435009612	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
478435009613	dimer interface [polypeptide binding]; other site
478435009614	active site
478435009615	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
478435009616	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
478435009617	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
478435009618	active site
478435009619	substrate binding site [chemical binding]; other site
478435009620	metal binding site [ion binding]; metal-binding site
478435009621	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
478435009622	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
478435009623	23S rRNA interface [nucleotide binding]; other site
478435009624	L3 interface [polypeptide binding]; other site
478435009625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435009626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435009627	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
478435009628	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
478435009629	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435009630	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
478435009631	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435009632	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435009633	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
478435009634	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
478435009635	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435009636	active site
478435009637	catalytic residues [active]
478435009638	Protein of unknown function (DUF690); Region: DUF690; cl04939
478435009639	Cutinase; Region: Cutinase; pfam01083
478435009640	Cutinase; Region: Cutinase; pfam01083
478435009641	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
478435009642	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
478435009643	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
478435009644	dimerization interface 3.5A [polypeptide binding]; other site
478435009645	active site
478435009646	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
478435009647	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
478435009648	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
478435009649	alphaNTD - beta interaction site [polypeptide binding]; other site
478435009650	alphaNTD homodimer interface [polypeptide binding]; other site
478435009651	alphaNTD - beta' interaction site [polypeptide binding]; other site
478435009652	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
478435009653	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
478435009654	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
478435009655	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
478435009656	RNA binding surface [nucleotide binding]; other site
478435009657	30S ribosomal protein S11; Validated; Region: PRK05309
478435009658	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
478435009659	30S ribosomal protein S13; Region: bact_S13; TIGR03631
478435009660	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
478435009661	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
478435009662	rRNA binding site [nucleotide binding]; other site
478435009663	predicted 30S ribosome binding site; other site
478435009664	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
478435009665	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
478435009666	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
478435009667	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
478435009668	NAD binding site [chemical binding]; other site
478435009669	substrate binding site [chemical binding]; other site
478435009670	homodimer interface [polypeptide binding]; other site
478435009671	active site
478435009672	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
478435009673	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435009674	Domain of unknown function (DUF222); Region: DUF222; pfam02720
478435009675	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
478435009676	active site
478435009677	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435009678	extended (e) SDRs; Region: SDR_e; cd08946
478435009679	NAD(P) binding site [chemical binding]; other site
478435009680	active site
478435009681	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
478435009682	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
478435009683	active site
478435009684	catalytic residues [active]
478435009685	metal binding site [ion binding]; metal-binding site
478435009686	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
478435009687	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
478435009688	PYR/PP interface [polypeptide binding]; other site
478435009689	dimer interface [polypeptide binding]; other site
478435009690	TPP binding site [chemical binding]; other site
478435009691	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
478435009692	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
478435009693	TPP-binding site [chemical binding]; other site
478435009694	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
478435009695	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
478435009696	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435009697	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
478435009698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435009699	metabolite-proton symporter; Region: 2A0106; TIGR00883
478435009700	putative substrate translocation pore; other site
478435009701	PE family; Region: PE; pfam00934
478435009702	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009703	PPE family; Region: PPE; pfam00823
478435009704	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435009705	patatin-related protein; Region: TIGR03607
478435009706	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435009707	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435009708	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
478435009709	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
478435009710	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
478435009711	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
478435009712	Transcriptional regulator [Transcription]; Region: LytR; COG1316
478435009713	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
478435009714	short chain dehydrogenase; Provisional; Region: PRK05875
478435009715	classical (c) SDRs; Region: SDR_c; cd05233
478435009716	NAD(P) binding site [chemical binding]; other site
478435009717	active site
478435009718	Predicted membrane protein [Function unknown]; Region: COG2259
478435009719	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
478435009720	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
478435009721	Predicted transcriptional regulators [Transcription]; Region: COG1695
478435009722	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
478435009723	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
478435009724	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
478435009725	active site
478435009726	homotetramer interface [polypeptide binding]; other site
478435009727	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009728	mce related protein; Region: MCE; pfam02470
478435009729	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009730	mce related protein; Region: MCE; pfam02470
478435009731	mce related protein; Region: MCE; pfam02470
478435009732	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009733	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435009734	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009735	mce related protein; Region: MCE; pfam02470
478435009736	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009737	mce related protein; Region: MCE; pfam02470
478435009738	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
478435009739	mce related protein; Region: MCE; pfam02470
478435009740	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
478435009741	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435009742	Permease; Region: Permease; pfam02405
478435009743	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
478435009744	Permease; Region: Permease; pfam02405
478435009745	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
478435009746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435009747	NAD(P) binding site [chemical binding]; other site
478435009748	active site
478435009749	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
478435009750	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
478435009751	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009752	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
478435009753	FAD binding site [chemical binding]; other site
478435009754	substrate binding site [chemical binding]; other site
478435009755	catalytic base [active]
478435009756	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009757	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009758	active site
478435009759	acyl-CoA synthetase; Validated; Region: PRK07867
478435009760	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
478435009761	acyl-activating enzyme (AAE) consensus motif; other site
478435009762	putative AMP binding site [chemical binding]; other site
478435009763	putative active site [active]
478435009764	putative CoA binding site [chemical binding]; other site
478435009765	PE family; Region: PE; pfam00934
478435009766	PE family; Region: PE; pfam00934
478435009767	hypothetical protein; Validated; Region: PRK07586
478435009768	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
478435009769	PYR/PP interface [polypeptide binding]; other site
478435009770	dimer interface [polypeptide binding]; other site
478435009771	TPP binding site [chemical binding]; other site
478435009772	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
478435009773	TPP-binding site [chemical binding]; other site
478435009774	dimer interface [polypeptide binding]; other site
478435009775	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
478435009776	PE family; Region: PE; pfam00934
478435009777	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435009778	CoA binding site [chemical binding]; other site
478435009779	PE family; Region: PE; pfam00934
478435009780	acyl-CoA synthetase; Validated; Region: PRK07798
478435009781	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435009782	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
478435009783	acyl-activating enzyme (AAE) consensus motif; other site
478435009784	acyl-activating enzyme (AAE) consensus motif; other site
478435009785	putative AMP binding site [chemical binding]; other site
478435009786	putative active site [active]
478435009787	putative CoA binding site [chemical binding]; other site
478435009788	enoyl-CoA hydratase; Provisional; Region: PRK07799
478435009789	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435009790	substrate binding site [chemical binding]; other site
478435009791	oxyanion hole (OAH) forming residues; other site
478435009792	trimer interface [polypeptide binding]; other site
478435009793	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
478435009794	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435009795	Cytochrome P450; Region: p450; cl12078
478435009796	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
478435009797	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
478435009798	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
478435009799	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
478435009800	DUF35 OB-fold domain; Region: DUF35; pfam01796
478435009801	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
478435009802	DUF35 OB-fold domain; Region: DUF35; pfam01796
478435009803	lipid-transfer protein; Provisional; Region: PRK07937
478435009804	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435009805	active site
478435009806	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
478435009807	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435009808	active site
478435009809	NHL repeat; Region: NHL; pfam01436
478435009810	Uncharacterized conserved protein [Function unknown]; Region: COG3391
478435009811	NHL repeat; Region: NHL; pfam01436
478435009812	NHL repeat; Region: NHL; pfam01436
478435009813	NHL repeat; Region: NHL; pfam01436
478435009814	NHL repeat; Region: NHL; pfam01436
478435009815	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
478435009816	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
478435009817	trimer interface [polypeptide binding]; other site
478435009818	putative metal binding site [ion binding]; other site
478435009819	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
478435009820	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
478435009821	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
478435009822	short chain dehydrogenase; Provisional; Region: PRK07890
478435009823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435009824	NAD(P) binding site [chemical binding]; other site
478435009825	active site
478435009826	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009827	PPE family; Region: PPE; pfam00823
478435009828	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
478435009829	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009830	PPE family; Region: PPE; pfam00823
478435009831	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009832	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009833	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
478435009834	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
478435009835	active site
478435009836	catalytic residues [active]
478435009837	metal binding site [ion binding]; metal-binding site
478435009838	DmpG-like communication domain; Region: DmpG_comm; pfam07836
478435009839	acetaldehyde dehydrogenase; Validated; Region: PRK08300
478435009840	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
478435009841	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
478435009842	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
478435009843	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
478435009844	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
478435009845	enoyl-CoA hydratase; Region: PLN02864
478435009846	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
478435009847	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
478435009848	dimer interaction site [polypeptide binding]; other site
478435009849	substrate-binding tunnel; other site
478435009850	active site
478435009851	catalytic site [active]
478435009852	substrate binding site [chemical binding]; other site
478435009853	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009854	PPE family; Region: PPE; pfam00823
478435009855	PE-PPE domain; Region: PE-PPE; pfam08237
478435009856	lipid-transfer protein; Provisional; Region: PRK07855
478435009857	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
478435009858	active site
478435009859	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
478435009860	putative active site [active]
478435009861	putative catalytic site [active]
478435009862	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
478435009863	active site
478435009864	catalytic site [active]
478435009865	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
478435009866	DUF35 OB-fold domain; Region: DUF35; pfam01796
478435009867	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009868	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009869	active site
478435009870	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009871	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
478435009872	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009873	active site
478435009874	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435009875	Cytochrome P450; Region: p450; cl12078
478435009876	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
478435009877	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435009878	dimer interface [polypeptide binding]; other site
478435009879	active site
478435009880	Domain of unknown function (DUF385); Region: DUF385; pfam04075
478435009881	short chain dehydrogenase; Provisional; Region: PRK07791
478435009882	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
478435009883	homodimer interface [polypeptide binding]; other site
478435009884	NAD binding site [chemical binding]; other site
478435009885	active site
478435009886	short chain dehydrogenase; Provisional; Region: PRK07856
478435009887	classical (c) SDRs; Region: SDR_c; cd05233
478435009888	NAD(P) binding site [chemical binding]; other site
478435009889	active site
478435009890	enoyl-CoA hydratase; Provisional; Region: PRK06495
478435009891	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435009892	substrate binding site [chemical binding]; other site
478435009893	oxyanion hole (OAH) forming residues; other site
478435009894	trimer interface [polypeptide binding]; other site
478435009895	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
478435009896	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
478435009897	Nitronate monooxygenase; Region: NMO; pfam03060
478435009898	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
478435009899	FMN binding site [chemical binding]; other site
478435009900	substrate binding site [chemical binding]; other site
478435009901	putative catalytic residue [active]
478435009902	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
478435009903	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
478435009904	putative di-iron ligands [ion binding]; other site
478435009905	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
478435009906	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
478435009907	FAD binding pocket [chemical binding]; other site
478435009908	FAD binding motif [chemical binding]; other site
478435009909	phosphate binding motif [ion binding]; other site
478435009910	beta-alpha-beta structure motif; other site
478435009911	NAD(p) ribose binding residues [chemical binding]; other site
478435009912	NAD binding pocket [chemical binding]; other site
478435009913	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
478435009914	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435009915	catalytic loop [active]
478435009916	iron binding site [ion binding]; other site
478435009917	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
478435009918	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
478435009919	putative active site [active]
478435009920	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
478435009921	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
478435009922	dimer interface [polypeptide binding]; other site
478435009923	active site
478435009924	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435009925	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435009926	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435009927	PPE family; Region: PPE; pfam00823
478435009928	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
478435009929	short chain dehydrogenase; Provisional; Region: PRK07831
478435009930	classical (c) SDRs; Region: SDR_c; cd05233
478435009931	NAD(P) binding site [chemical binding]; other site
478435009932	active site
478435009933	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009934	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009935	active site
478435009936	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
478435009937	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
478435009938	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
478435009939	acyl-activating enzyme (AAE) consensus motif; other site
478435009940	putative AMP binding site [chemical binding]; other site
478435009941	putative active site [active]
478435009942	putative CoA binding site [chemical binding]; other site
478435009943	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009944	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009945	active site
478435009946	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009947	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
478435009948	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009949	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009950	active site
478435009951	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009952	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
478435009953	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009954	active site
478435009955	aspartate aminotransferase; Provisional; Region: PRK05764
478435009956	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435009957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435009958	homodimer interface [polypeptide binding]; other site
478435009959	catalytic residue [active]
478435009960	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
478435009961	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
478435009962	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
478435009963	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
478435009964	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
478435009965	active site
478435009966	Fe binding site [ion binding]; other site
478435009967	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
478435009968	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009969	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
478435009970	Flavin binding site [chemical binding]; other site
478435009971	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
478435009972	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
478435009973	FAD binding pocket [chemical binding]; other site
478435009974	FAD binding motif [chemical binding]; other site
478435009975	phosphate binding motif [ion binding]; other site
478435009976	beta-alpha-beta structure motif; other site
478435009977	NAD(p) ribose binding residues [chemical binding]; other site
478435009978	NAD binding pocket [chemical binding]; other site
478435009979	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
478435009980	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
478435009981	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
478435009982	catalytic loop [active]
478435009983	iron binding site [ion binding]; other site
478435009984	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009985	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009986	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
478435009987	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435009988	active site
478435009989	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435009990	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435009991	Transcriptional regulators [Transcription]; Region: PurR; COG1609
478435009992	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
478435009993	DNA binding site [nucleotide binding]
478435009994	domain linker motif; other site
478435009995	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
478435009996	putative dimerization interface [polypeptide binding]; other site
478435009997	putative ligand binding site [chemical binding]; other site
478435009998	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435009999	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
478435010000	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
478435010001	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
478435010002	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
478435010003	transmembrane helices; other site
478435010004	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
478435010005	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
478435010006	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
478435010007	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
478435010008	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
478435010009	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
478435010010	active site
478435010011	HIGH motif; other site
478435010012	nucleotide binding site [chemical binding]; other site
478435010013	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
478435010014	KMSKS motif; other site
478435010015	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
478435010016	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
478435010017	homotrimer interaction site [polypeptide binding]; other site
478435010018	zinc binding site [ion binding]; other site
478435010019	CDP-binding sites; other site
478435010020	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
478435010021	substrate binding site; other site
478435010022	dimer interface; other site
478435010023	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
478435010024	DNA repair protein RadA; Provisional; Region: PRK11823
478435010025	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
478435010026	Walker A motif/ATP binding site; other site
478435010027	ATP binding site [chemical binding]; other site
478435010028	Walker B motif; other site
478435010029	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
478435010030	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
478435010031	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
478435010032	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
478435010033	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
478435010034	active site clefts [active]
478435010035	zinc binding site [ion binding]; other site
478435010036	dimer interface [polypeptide binding]; other site
478435010037	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
478435010038	endonuclease III; Region: ENDO3c; smart00478
478435010039	minor groove reading motif; other site
478435010040	helix-hairpin-helix signature motif; other site
478435010041	substrate binding pocket [chemical binding]; other site
478435010042	active site
478435010043	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
478435010044	PE family; Region: PE; pfam00934
478435010045	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435010046	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
478435010047	catalytic site [active]
478435010048	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
478435010049	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
478435010050	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
478435010051	Ami_2 domain; Region: Ami_2; smart00644
478435010052	amidase catalytic site [active]
478435010053	Zn binding residues [ion binding]; other site
478435010054	substrate binding site [chemical binding]; other site
478435010055	PE family; Region: PE; pfam00934
478435010056	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
478435010057	Clp amino terminal domain; Region: Clp_N; pfam02861
478435010058	Clp amino terminal domain; Region: Clp_N; pfam02861
478435010059	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010060	Walker A motif; other site
478435010061	ATP binding site [chemical binding]; other site
478435010062	Walker B motif; other site
478435010063	arginine finger; other site
478435010064	UvrB/uvrC motif; Region: UVR; pfam02151
478435010065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010066	Walker A motif; other site
478435010067	ATP binding site [chemical binding]; other site
478435010068	Walker B motif; other site
478435010069	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
478435010070	Lsr2; Region: Lsr2; pfam11774
478435010071	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
478435010072	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
478435010073	dimer interface [polypeptide binding]; other site
478435010074	putative anticodon binding site; other site
478435010075	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
478435010076	motif 1; other site
478435010077	dimer interface [polypeptide binding]; other site
478435010078	active site
478435010079	motif 2; other site
478435010080	motif 3; other site
478435010081	pantothenate kinase; Reviewed; Region: PRK13318
478435010082	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
478435010083	tetramerization interface [polypeptide binding]; other site
478435010084	active site
478435010085	Pantoate-beta-alanine ligase; Region: PanC; cd00560
478435010086	pantoate--beta-alanine ligase; Region: panC; TIGR00018
478435010087	active site
478435010088	ATP-binding site [chemical binding]; other site
478435010089	pantoate-binding site; other site
478435010090	HXXH motif; other site
478435010091	Rossmann-like domain; Region: Rossmann-like; pfam10727
478435010092	Uncharacterized conserved protein [Function unknown]; Region: COG5495
478435010093	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
478435010094	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
478435010095	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
478435010096	catalytic center binding site [active]
478435010097	ATP binding site [chemical binding]; other site
478435010098	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
478435010099	homooctamer interface [polypeptide binding]; other site
478435010100	active site
478435010101	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
478435010102	dihydropteroate synthase; Region: DHPS; TIGR01496
478435010103	substrate binding pocket [chemical binding]; other site
478435010104	dimer interface [polypeptide binding]; other site
478435010105	inhibitor binding site; inhibition site
478435010106	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
478435010107	homodecamer interface [polypeptide binding]; other site
478435010108	GTP cyclohydrolase I; Provisional; Region: PLN03044
478435010109	active site
478435010110	putative catalytic site residues [active]
478435010111	zinc binding site [ion binding]; other site
478435010112	GTP-CH-I/GFRP interaction surface; other site
478435010113	FtsH Extracellular; Region: FtsH_ext; pfam06480
478435010114	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
478435010115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010116	Walker A motif; other site
478435010117	ATP binding site [chemical binding]; other site
478435010118	Walker B motif; other site
478435010119	arginine finger; other site
478435010120	Peptidase family M41; Region: Peptidase_M41; pfam01434
478435010121	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
478435010122	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435010123	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
478435010124	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
478435010125	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
478435010126	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435010127	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
478435010128	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435010129	PPE family; Region: PPE; pfam00823
478435010130	PE family; Region: PE; pfam00934
478435010131	Uncharacterized conserved protein [Function unknown]; Region: COG2968
478435010132	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
478435010133	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
478435010134	active site
478435010135	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
478435010136	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
478435010137	Ligand Binding Site [chemical binding]; other site
478435010138	Uncharacterized conserved protein [Function unknown]; Region: COG5282
478435010139	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
478435010140	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
478435010141	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
478435010142	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
478435010143	dimer interface [polypeptide binding]; other site
478435010144	substrate binding site [chemical binding]; other site
478435010145	metal binding sites [ion binding]; metal-binding site
478435010146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
478435010147	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
478435010148	Ligand binding site; other site
478435010149	Putative Catalytic site; other site
478435010150	DXD motif; other site
478435010151	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
478435010152	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
478435010153	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435010154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435010155	NAD(P) binding site [chemical binding]; other site
478435010156	active site
478435010157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
478435010158	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
478435010159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
478435010160	transposase; Provisional; Region: PRK06526
478435010161	IstB-like ATP binding protein; Region: IstB_IS21; pfam01695
478435010162	Walker B motif; other site
478435010163	putative transposase OrfB; Reviewed; Region: PHA02517
478435010164	HTH-like domain; Region: HTH_21; pfam13276
478435010165	Integrase core domain; Region: rve; pfam00665
478435010166	Integrase core domain; Region: rve_3; pfam13683
478435010167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
478435010168	Transposase; Region: HTH_Tnp_1; cl17663
478435010169	Transposase, Mutator family; Region: Transposase_mut; pfam00872
478435010170	MULE transposase domain; Region: MULE; pfam10551
478435010171	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
478435010172	Fic/DOC family; Region: Fic; cl00960
478435010173	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
478435010174	DNA polymerase III subunit delta'; Validated; Region: PRK07940
478435010175	DNA polymerase III subunit delta'; Validated; Region: PRK08485
478435010176	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
478435010177	dimerization interface [polypeptide binding]; other site
478435010178	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
478435010179	cyclase homology domain; Region: CHD; cd07302
478435010180	nucleotidyl binding site; other site
478435010181	metal binding site [ion binding]; metal-binding site
478435010182	dimer interface [polypeptide binding]; other site
478435010183	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
478435010184	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
478435010185	active site
478435010186	interdomain interaction site; other site
478435010187	putative metal-binding site [ion binding]; other site
478435010188	nucleotide binding site [chemical binding]; other site
478435010189	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
478435010190	domain I; other site
478435010191	phosphate binding site [ion binding]; other site
478435010192	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
478435010193	domain II; other site
478435010194	domain III; other site
478435010195	nucleotide binding site [chemical binding]; other site
478435010196	DNA binding groove [nucleotide binding]
478435010197	catalytic site [active]
478435010198	domain IV; other site
478435010199	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
478435010200	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
478435010201	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
478435010202	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
478435010203	DNA-binding site [nucleotide binding]; DNA binding site
478435010204	RNA-binding motif; other site
478435010205	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
478435010206	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
478435010207	ATP binding site [chemical binding]; other site
478435010208	putative Mg++ binding site [ion binding]; other site
478435010209	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
478435010210	nucleotide binding region [chemical binding]; other site
478435010211	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
478435010212	PE family; Region: PE; pfam00934
478435010213	PE family; Region: PE; pfam00934
478435010214	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
478435010215	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
478435010216	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
478435010217	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
478435010218	Walker A motif; other site
478435010219	hexamer interface [polypeptide binding]; other site
478435010220	ATP binding site [chemical binding]; other site
478435010221	Walker B motif; other site
478435010222	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
478435010223	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
478435010224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435010225	motif II; other site
478435010226	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
478435010227	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
478435010228	Walker A/P-loop; other site
478435010229	ATP binding site [chemical binding]; other site
478435010230	Q-loop/lid; other site
478435010231	ABC transporter signature motif; other site
478435010232	Walker B; other site
478435010233	D-loop; other site
478435010234	H-loop/switch region; other site
478435010235	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
478435010236	Walker A/P-loop; other site
478435010237	ATP binding site [chemical binding]; other site
478435010238	Q-loop/lid; other site
478435010239	ABC transporter signature motif; other site
478435010240	Walker B; other site
478435010241	D-loop; other site
478435010242	H-loop/switch region; other site
478435010243	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
478435010244	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
478435010245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435010246	ABC-ATPase subunit interface; other site
478435010247	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
478435010248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435010249	dimer interface [polypeptide binding]; other site
478435010250	conserved gate region; other site
478435010251	ABC-ATPase subunit interface; other site
478435010252	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
478435010253	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
478435010254	acetyl-CoA synthetase; Provisional; Region: PRK00174
478435010255	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
478435010256	active site
478435010257	CoA binding site [chemical binding]; other site
478435010258	acyl-activating enzyme (AAE) consensus motif; other site
478435010259	AMP binding site [chemical binding]; other site
478435010260	acetate binding site [chemical binding]; other site
478435010261	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
478435010262	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
478435010263	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
478435010264	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
478435010265	putative active site [active]
478435010266	putative CoA binding site [chemical binding]; other site
478435010267	nudix motif; other site
478435010268	metal binding site [ion binding]; metal-binding site
478435010269	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
478435010270	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435010271	catalytic residues [active]
478435010272	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
478435010273	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
478435010274	minor groove reading motif; other site
478435010275	helix-hairpin-helix signature motif; other site
478435010276	substrate binding pocket [chemical binding]; other site
478435010277	active site
478435010278	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
478435010279	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435010280	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435010281	ligand binding site [chemical binding]; other site
478435010282	flexible hinge region; other site
478435010283	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
478435010284	putative switch regulator; other site
478435010285	non-specific DNA interactions [nucleotide binding]; other site
478435010286	DNA binding site [nucleotide binding]
478435010287	sequence specific DNA binding site [nucleotide binding]; other site
478435010288	putative cAMP binding site [chemical binding]; other site
478435010289	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
478435010290	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
478435010291	homotrimer interaction site [polypeptide binding]; other site
478435010292	putative active site [active]
478435010293	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
478435010294	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
478435010295	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
478435010296	P loop; other site
478435010297	Nucleotide binding site [chemical binding]; other site
478435010298	DTAP/Switch II; other site
478435010299	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
478435010300	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
478435010301	DTAP/Switch II; other site
478435010302	Switch I; other site
478435010303	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
478435010304	Transcription factor WhiB; Region: Whib; pfam02467
478435010305	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
478435010306	Transglycosylase; Region: Transgly; pfam00912
478435010307	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
478435010308	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
478435010309	phosphodiesterase YaeI; Provisional; Region: PRK11340
478435010310	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
478435010311	putative active site [active]
478435010312	putative metal binding site [ion binding]; other site
478435010313	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
478435010314	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
478435010315	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435010316	catalytic residue [active]
478435010317	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
478435010318	Cytochrome P450; Region: p450; cl12078
478435010319	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
478435010320	anti sigma factor interaction site; other site
478435010321	regulatory phosphorylation site [posttranslational modification]; other site
478435010322	Uncharacterized conserved protein [Function unknown]; Region: COG1610
478435010323	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
478435010324	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
478435010325	MoxR-like ATPases [General function prediction only]; Region: COG0714
478435010326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010327	Walker A motif; other site
478435010328	ATP binding site [chemical binding]; other site
478435010329	Walker B motif; other site
478435010330	arginine finger; other site
478435010331	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
478435010332	Protein of unknown function DUF58; Region: DUF58; pfam01882
478435010333	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
478435010334	Predicted membrane protein/domain [Function unknown]; Region: COG1714
478435010335	glycerol kinase; Provisional; Region: glpK; PRK00047
478435010336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
478435010337	nucleotide binding site [chemical binding]; other site
478435010338	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
478435010339	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
478435010340	Methyltransferase domain; Region: Methyltransf_23; pfam13489
478435010341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435010342	S-adenosylmethionine binding site [chemical binding]; other site
478435010343	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435010344	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
478435010345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435010346	catalytic residue [active]
478435010347	Uncharacterized conserved protein [Function unknown]; Region: COG4301
478435010348	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
478435010349	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
478435010350	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
478435010351	putative active site [active]
478435010352	putative dimer interface [polypeptide binding]; other site
478435010353	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
478435010354	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
478435010355	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
478435010356	PknH-like extracellular domain; Region: PknH_C; pfam14032
478435010357	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
478435010358	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
478435010359	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
478435010360	aspartate kinase; Reviewed; Region: PRK06635
478435010361	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
478435010362	putative nucleotide binding site [chemical binding]; other site
478435010363	putative catalytic residues [active]
478435010364	putative Mg ion binding site [ion binding]; other site
478435010365	putative aspartate binding site [chemical binding]; other site
478435010366	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
478435010367	putative allosteric regulatory site; other site
478435010368	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
478435010369	putative allosteric regulatory residue; other site
478435010370	2-isopropylmalate synthase; Validated; Region: PRK03739
478435010371	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
478435010372	active site
478435010373	catalytic residues [active]
478435010374	metal binding site [ion binding]; metal-binding site
478435010375	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
478435010376	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
478435010377	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
478435010378	active site
478435010379	catalytic site [active]
478435010380	substrate binding site [chemical binding]; other site
478435010381	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
478435010382	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
478435010383	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
478435010384	catalytic triad [active]
478435010385	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
478435010386	putative active site [active]
478435010387	recombination protein RecR; Reviewed; Region: recR; PRK00076
478435010388	RecR protein; Region: RecR; pfam02132
478435010389	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
478435010390	putative active site [active]
478435010391	putative metal-binding site [ion binding]; other site
478435010392	tetramer interface [polypeptide binding]; other site
478435010393	hypothetical protein; Validated; Region: PRK00153
478435010394	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
478435010395	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
478435010396	active site
478435010397	metal binding site [ion binding]; metal-binding site
478435010398	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
478435010399	hydrophobic ligand binding site; other site
478435010400	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435010401	FAD binding domain; Region: FAD_binding_4; pfam01565
478435010402	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
478435010403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435010404	S-adenosylmethionine binding site [chemical binding]; other site
478435010405	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
478435010406	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010407	Walker A motif; other site
478435010408	ATP binding site [chemical binding]; other site
478435010409	Walker B motif; other site
478435010410	arginine finger; other site
478435010411	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
478435010412	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
478435010413	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
478435010414	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435010415	catalytic residue [active]
478435010416	Cutinase; Region: Cutinase; pfam01083
478435010417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435010418	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
478435010419	NAD(P) binding site [chemical binding]; other site
478435010420	active site
478435010421	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
478435010422	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
478435010423	putative NAD(P) binding site [chemical binding]; other site
478435010424	catalytic Zn binding site [ion binding]; other site
478435010425	Uncharacterized conserved protein [Function unknown]; Region: COG3349
478435010426	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
478435010427	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
478435010428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
478435010429	putative substrate translocation pore; other site
478435010430	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
478435010431	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
478435010432	ligand binding site [chemical binding]; other site
478435010433	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
478435010434	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
478435010435	active site
478435010436	nucleophile elbow; other site
478435010437	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
478435010438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
478435010439	FeS/SAM binding site; other site
478435010440	Methyltransferase domain; Region: Methyltransf_31; pfam13847
478435010441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435010442	S-adenosylmethionine binding site [chemical binding]; other site
478435010443	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
478435010444	nucleotide binding site [chemical binding]; other site
478435010445	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
478435010446	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
478435010447	active site
478435010448	DNA binding site [nucleotide binding]
478435010449	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
478435010450	DNA binding site [nucleotide binding]
478435010451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
478435010452	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
478435010453	nudix motif; other site
478435010454	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435010455	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435010456	Uncharacterized conserved protein [Function unknown]; Region: COG1839
478435010457	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
478435010458	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
478435010459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
478435010460	Uncharacterized conserved protein [Function unknown]; Region: COG2966
478435010461	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
478435010462	Uncharacterized conserved protein [Function unknown]; Region: COG3610
478435010463	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435010464	PPE family; Region: PPE; pfam00823
478435010465	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435010466	PPE family; Region: PPE; pfam00823
478435010467	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
478435010468	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
478435010469	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435010470	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435010471	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
478435010472	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
478435010473	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
478435010474	Soluble P-type ATPase [General function prediction only]; Region: COG4087
478435010475	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
478435010476	dimerization interface [polypeptide binding]; other site
478435010477	putative DNA binding site [nucleotide binding]; other site
478435010478	putative Zn2+ binding site [ion binding]; other site
478435010479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651
478435010480	DNA binding domain, excisionase family; Region: excise; TIGR01764
478435010481	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
478435010482	active site
478435010483	Int/Topo IB signature motif; other site
478435010484	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
478435010485	nucleoside/Zn binding site; other site
478435010486	dimer interface [polypeptide binding]; other site
478435010487	catalytic motif [active]
478435010488	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
478435010489	prephenate dehydrogenase; Validated; Region: PRK06545
478435010490	prephenate dehydrogenase; Validated; Region: PRK08507
478435010491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554
478435010492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
478435010493	ABC-ATPase subunit interface; other site
478435010494	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
478435010495	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
478435010496	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
478435010497	Walker A/P-loop; other site
478435010498	ATP binding site [chemical binding]; other site
478435010499	Q-loop/lid; other site
478435010500	ABC transporter signature motif; other site
478435010501	Walker B; other site
478435010502	D-loop; other site
478435010503	H-loop/switch region; other site
478435010504	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
478435010505	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
478435010506	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
478435010507	putative active site [active]
478435010508	putative substrate binding site [chemical binding]; other site
478435010509	ATP binding site [chemical binding]; other site
478435010510	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
478435010511	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
478435010512	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
478435010513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
478435010514	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
478435010515	dimerization interface [polypeptide binding]; other site
478435010516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
478435010517	dimer interface [polypeptide binding]; other site
478435010518	phosphorylation site [posttranslational modification]
478435010519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
478435010520	ATP binding site [chemical binding]; other site
478435010521	Mg2+ binding site [ion binding]; other site
478435010522	G-X-G motif; other site
478435010523	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
478435010524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
478435010525	active site
478435010526	phosphorylation site [posttranslational modification]
478435010527	intermolecular recognition site; other site
478435010528	dimerization interface [polypeptide binding]; other site
478435010529	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
478435010530	DNA binding site [nucleotide binding]
478435010531	Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243
478435010532	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435010533	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435010534	SnoaL-like domain; Region: SnoaL_2; pfam12680
478435010535	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
478435010536	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
478435010537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
478435010538	homodimer interface [polypeptide binding]; other site
478435010539	catalytic residue [active]
478435010540	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
478435010541	TIGR03086 family protein; Region: TIGR03086
478435010542	enoyl-CoA hydratase; Provisional; Region: PRK06142
478435010543	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
478435010544	substrate binding site [chemical binding]; other site
478435010545	oxyanion hole (OAH) forming residues; other site
478435010546	trimer interface [polypeptide binding]; other site
478435010547	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
478435010548	Beta-lactamase; Region: Beta-lactamase; pfam00144
478435010549	potential protein location (hypothetical protein TBXG_003793 [Mycobacterium tuberculosis KZN 605]) that overlaps RNA (tRNA-S)
478435010550	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
478435010551	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
478435010552	NAD(P) binding site [chemical binding]; other site
478435010553	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
478435010554	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
478435010555	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
478435010556	catalytic residue [active]
478435010557	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
478435010558	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
478435010559	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
478435010560	Walker A/P-loop; other site
478435010561	ATP binding site [chemical binding]; other site
478435010562	Q-loop/lid; other site
478435010563	ABC transporter signature motif; other site
478435010564	Walker B; other site
478435010565	D-loop; other site
478435010566	H-loop/switch region; other site
478435010567	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
478435010568	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
478435010569	active site
478435010570	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
478435010571	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
478435010572	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
478435010573	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
478435010574	NAD binding site [chemical binding]; other site
478435010575	substrate binding site [chemical binding]; other site
478435010576	active site
478435010577	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
478435010578	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
478435010579	active site
478435010580	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
478435010581	Peptidase family M23; Region: Peptidase_M23; pfam01551
478435010582	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
478435010583	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
478435010584	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
478435010585	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
478435010586	Predicted membrane protein [Function unknown]; Region: COG2246
478435010587	GtrA-like protein; Region: GtrA; pfam04138
478435010588	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
478435010589	FAD binding domain; Region: FAD_binding_4; pfam01565
478435010590	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
478435010591	short chain dehydrogenase; Provisional; Region: PRK07904
478435010592	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
478435010593	NAD(P) binding site [chemical binding]; other site
478435010594	active site
478435010595	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
478435010596	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
478435010597	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
478435010598	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
478435010599	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
478435010600	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
478435010601	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
478435010602	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
478435010603	FAD binding site [chemical binding]; other site
478435010604	substrate binding site [chemical binding]; other site
478435010605	catalytic residues [active]
478435010606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
478435010607	Transposase; Region: DDE_Tnp_ISL3; pfam01610
478435010608	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
478435010609	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
478435010610	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
478435010611	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435010612	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435010613	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
478435010614	active site
478435010615	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
478435010616	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435010617	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435010618	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
478435010619	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
478435010620	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435010621	acyl-activating enzyme (AAE) consensus motif; other site
478435010622	active site
478435010623	Cutinase; Region: Cutinase; pfam01083
478435010624	Predicted esterase [General function prediction only]; Region: COG0627
478435010625	Putative esterase; Region: Esterase; pfam00756
478435010626	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
478435010627	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
478435010628	active site
478435010629	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
478435010630	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
478435010631	active site
478435010632	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
478435010633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435010634	UDP-galactopyranose mutase; Region: GLF; pfam03275
478435010635	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
478435010636	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
478435010637	amidase catalytic site [active]
478435010638	Zn binding residues [ion binding]; other site
478435010639	substrate binding site [chemical binding]; other site
478435010640	LGFP repeat; Region: LGFP; pfam08310
478435010641	PE family; Region: PE; pfam00934
478435010642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
478435010643	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
478435010644	active site
478435010645	motif I; other site
478435010646	motif II; other site
478435010647	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
478435010648	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435010649	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435010650	putative acyl-acceptor binding pocket; other site
478435010651	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435010652	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435010653	putative acyl-acceptor binding pocket; other site
478435010654	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
478435010655	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
478435010656	putative acyl-acceptor binding pocket; other site
478435010657	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
478435010658	Phosphotransferase enzyme family; Region: APH; pfam01636
478435010659	active site
478435010660	ATP binding site [chemical binding]; other site
478435010661	antibiotic binding site [chemical binding]; other site
478435010662	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
478435010663	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
478435010664	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
478435010665	iron-sulfur cluster [ion binding]; other site
478435010666	[2Fe-2S] cluster binding site [ion binding]; other site
478435010667	Condensation domain; Region: Condensation; pfam00668
478435010668	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
478435010669	PE-PPE domain; Region: PE-PPE; pfam08237
478435010670	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
478435010671	Condensation domain; Region: Condensation; pfam00668
478435010672	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
478435010673	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
478435010674	active site
478435010675	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
478435010676	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
478435010677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
478435010678	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
478435010679	Enoylreductase; Region: PKS_ER; smart00829
478435010680	NAD(P) binding site [chemical binding]; other site
478435010681	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
478435010682	KR domain; Region: KR; pfam08659
478435010683	putative NADP binding site [chemical binding]; other site
478435010684	active site
478435010685	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
478435010686	acyl-CoA synthetase; Validated; Region: PRK05850
478435010687	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
478435010688	acyl-activating enzyme (AAE) consensus motif; other site
478435010689	active site
478435010690	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
478435010691	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
478435010692	Probable transposase; Region: OrfB_IS605; pfam01385
478435010693	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
478435010694	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
478435010695	catalytic residues [active]
478435010696	catalytic nucleophile [active]
478435010697	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
478435010698	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435010699	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
478435010700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435010701	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
478435010702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
478435010703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
478435010704	Cupin domain; Region: Cupin_2; cl17218
478435010705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
478435010706	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
478435010707	seryl-tRNA synthetase; Provisional; Region: PRK05431
478435010708	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
478435010709	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
478435010710	dimer interface [polypeptide binding]; other site
478435010711	active site
478435010712	motif 1; other site
478435010713	motif 2; other site
478435010714	motif 3; other site
478435010715	Septum formation; Region: Septum_form; pfam13845
478435010716	Septum formation; Region: Septum_form; pfam13845
478435010717	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
478435010718	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
478435010719	catalytic core [active]
478435010720	prephenate dehydratase; Provisional; Region: PRK11898
478435010721	Prephenate dehydratase; Region: PDT; pfam00800
478435010722	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
478435010723	putative L-Phe binding site [chemical binding]; other site
478435010724	Transcriptional regulator [Transcription]; Region: LytR; COG1316
478435010725	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
478435010726	Ferritin-like domain; Region: Ferritin; pfam00210
478435010727	ferroxidase diiron center [ion binding]; other site
478435010728	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
478435010729	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
478435010730	putative active site [active]
478435010731	catalytic site [active]
478435010732	putative metal binding site [ion binding]; other site
478435010733	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
478435010734	Transposase; Region: DEDD_Tnp_IS110; pfam01548
478435010735	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
478435010736	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
478435010737	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
478435010738	Predicted membrane protein [Function unknown]; Region: COG2119
478435010739	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
478435010740	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
478435010741	Fimbrial protein; Region: Fimbrial; cl01416
478435010742	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
478435010743	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
478435010744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
478435010745	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
478435010746	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
478435010747	hypothetical protein; Provisional; Region: PRK07945
478435010748	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
478435010749	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
478435010750	active site
478435010751	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
478435010752	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
478435010753	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
478435010754	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
478435010755	active site
478435010756	dimer interface [polypeptide binding]; other site
478435010757	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
478435010758	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
478435010759	active site
478435010760	FMN binding site [chemical binding]; other site
478435010761	substrate binding site [chemical binding]; other site
478435010762	3Fe-4S cluster binding site [ion binding]; other site
478435010763	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
478435010764	domain interface; other site
478435010765	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
478435010766	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
478435010767	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
478435010768	EspG family; Region: ESX-1_EspG; pfam14011
478435010769	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
478435010770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010771	Walker A motif; other site
478435010772	ATP binding site [chemical binding]; other site
478435010773	Walker B motif; other site
478435010774	arginine finger; other site
478435010775	Protein of unknown function (DUF690); Region: DUF690; pfam05108
478435010776	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
478435010777	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010778	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
478435010779	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010780	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010781	PE family; Region: PE; pfam00934
478435010782	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
478435010783	PPE family; Region: PPE; pfam00823
478435010784	Proteins of 100 residues with WXG; Region: WXG100; cl02005
478435010785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435010786	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
478435010787	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
478435010788	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
478435010789	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
478435010790	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435010791	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
478435010792	active site
478435010793	catalytic residues [active]
478435010794	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
478435010795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
478435010796	Walker A motif; other site
478435010797	ATP binding site [chemical binding]; other site
478435010798	Walker B motif; other site
478435010799	arginine finger; other site
478435010800	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
478435010801	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435010802	catalytic residues [active]
478435010803	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
478435010804	active site
478435010805	catalytic residues [active]
478435010806	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
478435010807	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
478435010808	EspG family; Region: ESX-1_EspG; pfam14011
478435010809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435010810	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
478435010811	PPE family; Region: PPE; pfam00823
478435010812	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
478435010813	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010814	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
478435010815	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010816	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
478435010817	Protein of unknown function (DUF690); Region: DUF690; pfam05108
478435010818	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
478435010819	N-acetyl-D-glucosamine binding site [chemical binding]; other site
478435010820	catalytic residue [active]
478435010821	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
478435010822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
478435010823	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
478435010824	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
478435010825	active site
478435010826	NTP binding site [chemical binding]; other site
478435010827	metal binding triad [ion binding]; metal-binding site
478435010828	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
478435010829	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
478435010830	Zn2+ binding site [ion binding]; other site
478435010831	Mg2+ binding site [ion binding]; other site
478435010832	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
478435010833	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
478435010834	active site
478435010835	Ap6A binding site [chemical binding]; other site
478435010836	nudix motif; other site
478435010837	metal binding site [ion binding]; metal-binding site
478435010838	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
478435010839	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
478435010840	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
478435010841	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
478435010842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
478435010843	DNA binding residues [nucleotide binding]
478435010844	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
478435010845	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
478435010846	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
478435010847	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
478435010848	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
478435010849	catalytic residues [active]
478435010850	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
478435010851	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
478435010852	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
478435010853	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
478435010854	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
478435010855	active site
478435010856	metal binding site [ion binding]; metal-binding site
478435010857	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
478435010858	ParB-like nuclease domain; Region: ParB; smart00470
478435010859	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
478435010860	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435010861	P-loop; other site
478435010862	Magnesium ion binding site [ion binding]; other site
478435010863	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
478435010864	Magnesium ion binding site [ion binding]; other site
478435010865	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
478435010866	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
478435010867	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
478435010868	G-X-X-G motif; other site
478435010869	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
478435010870	RxxxH motif; other site
478435010871	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
478435010872	Uncharacterized conserved protein [Function unknown]; Region: COG0759
478435010873	ribonuclease P; Reviewed; Region: rnpA; PRK00588
478435010874	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399