-- dump date 20140619_154719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 83332000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 83332000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332000003 Walker A motif; other site 83332000004 ATP binding site [chemical binding]; other site 83332000005 Walker B motif; other site 83332000006 arginine finger; other site 83332000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 83332000008 DnaA box-binding interface [nucleotide binding]; other site 83332000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 83332000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 83332000011 putative DNA binding surface [nucleotide binding]; other site 83332000012 dimer interface [polypeptide binding]; other site 83332000013 beta-clamp/clamp loader binding surface; other site 83332000014 beta-clamp/translesion DNA polymerase binding surface; other site 83332000015 recF protein; Region: recf; TIGR00611 83332000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 83332000017 Walker A/P-loop; other site 83332000018 ATP binding site [chemical binding]; other site 83332000019 Q-loop/lid; other site 83332000020 ABC transporter signature motif; other site 83332000021 Walker B; other site 83332000022 D-loop; other site 83332000023 H-loop/switch region; other site 83332000024 hypothetical protein; Provisional; Region: PRK03195 83332000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 83332000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332000027 ATP binding site [chemical binding]; other site 83332000028 Mg2+ binding site [ion binding]; other site 83332000029 G-X-G motif; other site 83332000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 83332000031 anchoring element; other site 83332000032 dimer interface [polypeptide binding]; other site 83332000033 ATP binding site [chemical binding]; other site 83332000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 83332000035 active site 83332000036 putative metal-binding site [ion binding]; other site 83332000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 83332000038 DNA gyrase subunit A; Validated; Region: PRK05560 83332000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 83332000040 CAP-like domain; other site 83332000041 active site 83332000042 primary dimer interface [polypeptide binding]; other site 83332000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 83332000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 83332000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 83332000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 83332000052 active site 83332000053 Bacterial PH domain; Region: bPH_6; pfam10756 83332000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 83332000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332000056 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 83332000057 Glutamine amidotransferase class-I; Region: GATase; pfam00117 83332000058 glutamine binding [chemical binding]; other site 83332000059 catalytic triad [active] 83332000060 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 83332000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332000062 active site 83332000063 ATP binding site [chemical binding]; other site 83332000064 substrate binding site [chemical binding]; other site 83332000065 activation loop (A-loop); other site 83332000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 83332000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332000071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332000072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332000073 active site 83332000074 ATP binding site [chemical binding]; other site 83332000075 substrate binding site [chemical binding]; other site 83332000076 activation loop (A-loop); other site 83332000077 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332000078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332000079 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 83332000080 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 83332000081 active site 83332000082 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 83332000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332000085 phosphopeptide binding site; other site 83332000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 83332000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332000089 phosphopeptide binding site; other site 83332000090 Nitronate monooxygenase; Region: NMO; pfam03060 83332000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332000092 FMN binding site [chemical binding]; other site 83332000093 substrate binding site [chemical binding]; other site 83332000094 putative catalytic residue [active] 83332000095 Transcription factor WhiB; Region: Whib; pfam02467 83332000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332000098 non-specific DNA binding site [nucleotide binding]; other site 83332000099 salt bridge; other site 83332000100 sequence-specific DNA binding site [nucleotide binding]; other site 83332000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 83332000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 83332000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 83332000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 83332000110 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 83332000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332000112 catalytic residue [active] 83332000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 83332000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 83332000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 83332000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332000117 acyl-activating enzyme (AAE) consensus motif; other site 83332000118 active site 83332000119 TIGR03084 family protein; Region: TIGR03084 83332000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332000121 Wyosine base formation; Region: Wyosine_form; pfam08608 83332000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 83332000123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332000124 putative substrate translocation pore; other site 83332000125 hypothetical protein; Validated; Region: PRK00228 83332000126 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332000127 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 83332000128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332000129 active site 83332000130 HIGH motif; other site 83332000131 nucleotide binding site [chemical binding]; other site 83332000132 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 83332000133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332000134 active site 83332000135 KMSKS motif; other site 83332000136 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 83332000137 tRNA binding surface [nucleotide binding]; other site 83332000138 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332000139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 83332000140 Transcriptional regulators [Transcription]; Region: GntR; COG1802 83332000141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332000142 DNA-binding site [nucleotide binding]; DNA binding site 83332000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332000144 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332000145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000146 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332000147 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 83332000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 83332000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332000150 Transglycosylase; Region: Transgly; pfam00912 83332000151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 83332000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 83332000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 83332000155 conserved cys residue [active] 83332000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 83332000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 83332000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 83332000159 dimer interface [polypeptide binding]; other site 83332000160 ssDNA binding site [nucleotide binding]; other site 83332000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 83332000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 83332000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 83332000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 83332000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 83332000166 replicative DNA helicase; Validated; Region: PRK07773 83332000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 83332000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 83332000169 Walker A motif; other site 83332000170 ATP binding site [chemical binding]; other site 83332000171 Walker B motif; other site 83332000172 DNA binding loops [nucleotide binding] 83332000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332000174 protein-splicing catalytic site; other site 83332000175 thioester formation/cholesterol transfer; other site 83332000176 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 83332000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332000178 protein-splicing catalytic site; other site 83332000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 83332000180 Domain of unknown function (DUF4433); Region: DUF4433; pfam14487 83332000181 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 83332000182 ADP-ribose binding site [chemical binding]; other site 83332000183 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 83332000184 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 83332000185 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 83332000186 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332000187 FAD binding domain; Region: FAD_binding_4; pfam01565 83332000188 Berberine and berberine like; Region: BBE; pfam08031 83332000189 hypothetical protein; Provisional; Region: PRK12438 83332000190 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332000191 homotetrameric interface [polypeptide binding]; other site 83332000192 putative active site [active] 83332000193 metal binding site [ion binding]; metal-binding site 83332000194 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 83332000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000197 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332000198 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 83332000199 putative NAD(P) binding site [chemical binding]; other site 83332000200 active site 83332000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 83332000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 83332000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 83332000204 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 83332000205 dimer interface [polypeptide binding]; other site 83332000206 active site 83332000207 glycine-pyridoxal phosphate binding site [chemical binding]; other site 83332000208 folate binding site [chemical binding]; other site 83332000209 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 83332000210 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 83332000211 putative NTP binding site [chemical binding]; other site 83332000212 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 83332000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332000214 FtsX-like permease family; Region: FtsX; pfam02687 83332000215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332000216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332000217 Walker A/P-loop; other site 83332000218 ATP binding site [chemical binding]; other site 83332000219 Q-loop/lid; other site 83332000220 ABC transporter signature motif; other site 83332000221 Walker B; other site 83332000222 D-loop; other site 83332000223 H-loop/switch region; other site 83332000224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332000225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332000226 ligand binding site [chemical binding]; other site 83332000227 flexible hinge region; other site 83332000228 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 83332000229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332000230 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 83332000231 active site 83332000232 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 83332000233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332000234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332000235 homodimer interface [polypeptide binding]; other site 83332000236 catalytic residue [active] 83332000237 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332000238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000241 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 83332000242 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 83332000243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332000244 dimerization interface [polypeptide binding]; other site 83332000245 putative DNA binding site [nucleotide binding]; other site 83332000246 putative Zn2+ binding site [ion binding]; other site 83332000247 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 83332000248 hydrogenase 4 subunit B; Validated; Region: PRK06521 83332000249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332000250 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 83332000251 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 83332000252 hydrogenase 4 subunit F; Validated; Region: PRK06458 83332000253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332000254 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 83332000255 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 83332000256 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 83332000257 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 83332000258 putative hydrophobic ligand binding site [chemical binding]; other site 83332000259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000260 S-adenosylmethionine binding site [chemical binding]; other site 83332000261 Predicted membrane protein [Function unknown]; Region: COG3305 83332000262 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 83332000263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332000264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 83332000265 metal-binding site [ion binding] 83332000266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000267 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332000268 Predicted integral membrane protein [Function unknown]; Region: COG5660 83332000269 Putative zinc-finger; Region: zf-HC2; pfam13490 83332000270 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332000272 active site 83332000273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000275 PPE family; Region: PPE; pfam00823 83332000276 Gammaherpesvirus capsid protein; Region: Herpes_capsid; pfam06112 83332000277 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 83332000278 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 83332000279 FcoT-like thioesterase domain; Region: FcoT; pfam10862 83332000280 acyl-CoA synthetase; Validated; Region: PRK05857 83332000281 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 83332000282 acyl-activating enzyme (AAE) consensus motif; other site 83332000283 AMP binding site [chemical binding]; other site 83332000284 active site 83332000285 CoA binding site [chemical binding]; other site 83332000286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000288 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 83332000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000290 acyl-activating enzyme (AAE) consensus motif; other site 83332000291 acyl-activating enzyme (AAE) consensus motif; other site 83332000292 AMP binding site [chemical binding]; other site 83332000293 active site 83332000294 CoA binding site [chemical binding]; other site 83332000295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000296 Condensation domain; Region: Condensation; pfam00668 83332000297 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332000298 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332000299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332000300 acyl-activating enzyme (AAE) consensus motif; other site 83332000301 AMP binding site [chemical binding]; other site 83332000302 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332000303 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 83332000304 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 83332000305 putative NAD(P) binding site [chemical binding]; other site 83332000306 active site 83332000307 putative substrate binding site [chemical binding]; other site 83332000308 Predicted membrane protein [Function unknown]; Region: COG3336 83332000309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332000310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 83332000311 metal-binding site [ion binding] 83332000312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332000314 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 83332000315 NAD binding site [chemical binding]; other site 83332000316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332000317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332000318 ligand binding site [chemical binding]; other site 83332000319 flexible hinge region; other site 83332000320 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 83332000321 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 83332000322 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 83332000323 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332000324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332000325 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 83332000326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332000327 motif II; other site 83332000328 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332000329 PE family; Region: PE; pfam00934 83332000330 Rhomboid family; Region: Rhomboid; pfam01694 83332000331 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332000332 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 83332000333 active site 83332000334 catalytic triad [active] 83332000335 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332000336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332000337 NAD(P) binding site [chemical binding]; other site 83332000338 active site 83332000339 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 83332000340 dimer interface [polypeptide binding]; other site 83332000341 active site 83332000342 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 83332000343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332000344 active site 83332000345 motif I; other site 83332000346 motif II; other site 83332000347 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 83332000348 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 83332000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332000350 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 83332000351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332000352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332000353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 83332000355 dimerization interface [polypeptide binding]; other site 83332000356 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 83332000357 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332000358 PYR/PP interface [polypeptide binding]; other site 83332000359 dimer interface [polypeptide binding]; other site 83332000360 TPP binding site [chemical binding]; other site 83332000361 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332000362 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 83332000363 TPP-binding site; other site 83332000364 dimer interface [polypeptide binding]; other site 83332000365 acyl-CoA synthetase; Validated; Region: PRK05852 83332000366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000367 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 83332000368 acyl-activating enzyme (AAE) consensus motif; other site 83332000369 acyl-activating enzyme (AAE) consensus motif; other site 83332000370 putative AMP binding site [chemical binding]; other site 83332000371 putative active site [active] 83332000372 putative CoA binding site [chemical binding]; other site 83332000373 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000374 elongation factor G; Reviewed; Region: PRK12740 83332000375 G1 box; other site 83332000376 GTP/Mg2+ binding site [chemical binding]; other site 83332000377 G2 box; other site 83332000378 Switch I region; other site 83332000379 G3 box; other site 83332000380 Switch II region; other site 83332000381 G4 box; other site 83332000382 G5 box; other site 83332000383 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 83332000384 Elongation Factor G, domain II; Region: EFG_II; pfam14492 83332000385 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 83332000386 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 83332000387 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 83332000388 PE family; Region: PE; pfam00934 83332000389 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 83332000390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332000391 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 83332000392 protein binding site [polypeptide binding]; other site 83332000393 trehalose synthase; Region: treS_nterm; TIGR02456 83332000394 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 83332000395 active site 83332000396 catalytic site [active] 83332000397 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 83332000398 Predicted membrane protein [Function unknown]; Region: COG3619 83332000399 Predicted esterase [General function prediction only]; Region: COG0627 83332000400 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 83332000401 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 83332000402 putative active site [active] 83332000403 putative catalytic site [active] 83332000404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000406 active site 83332000407 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332000408 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332000409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332000410 Coenzyme A binding pocket [chemical binding]; other site 83332000411 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332000412 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000413 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332000414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000416 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332000417 methionine sulfoxide reductase A; Provisional; Region: PRK14054 83332000418 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000419 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 83332000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332000421 NAD(P) binding site [chemical binding]; other site 83332000422 active site 83332000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332000424 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 83332000425 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 83332000426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332000427 minor groove reading motif; other site 83332000428 helix-hairpin-helix signature motif; other site 83332000429 active site 83332000430 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 83332000431 Cl- selectivity filter; other site 83332000432 Cl- binding residues [ion binding]; other site 83332000433 pore gating glutamate residue; other site 83332000434 dimer interface [polypeptide binding]; other site 83332000435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000437 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332000438 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332000439 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 83332000440 NAD(P) binding site [chemical binding]; other site 83332000441 catalytic residues [active] 83332000442 short chain dehydrogenase; Provisional; Region: PRK07791 83332000443 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 83332000444 NAD binding site [chemical binding]; other site 83332000445 homodimer interface [polypeptide binding]; other site 83332000446 active site 83332000447 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332000448 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 83332000449 NAD(P) binding site [chemical binding]; other site 83332000450 PE family; Region: PE; pfam00934 83332000451 PE-PPE domain; Region: PE-PPE; pfam08237 83332000452 PE-PPE domain; Region: PE-PPE; pfam08237 83332000453 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 83332000454 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 83332000455 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 83332000456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000457 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 83332000458 FAD binding site [chemical binding]; other site 83332000459 substrate binding site [chemical binding]; other site 83332000460 catalytic base [active] 83332000461 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 83332000462 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 83332000463 ligand binding site [chemical binding]; other site 83332000464 homodimer interface [polypeptide binding]; other site 83332000465 NAD(P) binding site [chemical binding]; other site 83332000466 trimer interface B [polypeptide binding]; other site 83332000467 trimer interface A [polypeptide binding]; other site 83332000468 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 83332000469 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 83332000470 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 83332000471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000473 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 83332000474 PE family; Region: PE; pfam00934 83332000475 PE-PPE domain; Region: PE-PPE; pfam08237 83332000476 PE family; Region: PE; pfam00934 83332000477 PE-PPE domain; Region: PE-PPE; pfam08237 83332000478 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332000479 FAD binding domain; Region: FAD_binding_4; pfam01565 83332000480 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 83332000481 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 83332000482 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332000483 NAD(P) binding site [chemical binding]; other site 83332000484 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332000485 active site 83332000486 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332000487 putative hydrophobic ligand binding site [chemical binding]; other site 83332000488 Transcriptional regulators [Transcription]; Region: GntR; COG1802 83332000489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 83332000490 DNA-binding site [nucleotide binding]; DNA binding site 83332000491 FCD domain; Region: FCD; pfam07729 83332000492 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 83332000493 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332000494 acyl-activating enzyme (AAE) consensus motif; other site 83332000495 putative AMP binding site [chemical binding]; other site 83332000496 putative active site [active] 83332000497 putative CoA binding site [chemical binding]; other site 83332000498 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332000499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332000500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000501 mce related protein; Region: MCE; pfam02470 83332000502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332000503 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 83332000504 mce related protein; Region: MCE; pfam02470 83332000505 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000507 mce related protein; Region: MCE; pfam02470 83332000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000509 mce related protein; Region: MCE; pfam02470 83332000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000511 mce related protein; Region: MCE; pfam02470 83332000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332000513 mce related protein; Region: MCE; pfam02470 83332000514 RDD family; Region: RDD; pfam06271 83332000515 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 83332000516 Predicted membrane protein [Function unknown]; Region: COG1511 83332000517 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 83332000518 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 83332000519 Pirin-related protein [General function prediction only]; Region: COG1741 83332000520 Pirin; Region: Pirin; pfam02678 83332000521 RNA polymerase factor sigma-70; Validated; Region: PRK08241 83332000522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332000523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332000524 DNA binding residues [nucleotide binding] 83332000525 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000526 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 83332000527 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 83332000528 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332000529 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 83332000530 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 83332000531 Probable beta-xylosidase; Provisional; Region: PLN03080 83332000532 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 83332000533 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 83332000534 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 83332000535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000536 S-adenosylmethionine binding site [chemical binding]; other site 83332000537 SPW repeat; Region: SPW; pfam03779 83332000538 SPW repeat; Region: SPW; pfam03779 83332000539 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 83332000540 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 83332000541 putative homodimer interface [polypeptide binding]; other site 83332000542 putative homotetramer interface [polypeptide binding]; other site 83332000543 putative allosteric switch controlling residues; other site 83332000544 putative metal binding site [ion binding]; other site 83332000545 putative homodimer-homodimer interface [polypeptide binding]; other site 83332000546 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 83332000547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332000548 putative substrate translocation pore; other site 83332000549 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332000550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332000551 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332000552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332000553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332000554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332000555 Walker A/P-loop; other site 83332000556 ATP binding site [chemical binding]; other site 83332000557 Q-loop/lid; other site 83332000558 ABC transporter signature motif; other site 83332000559 Walker B; other site 83332000560 D-loop; other site 83332000561 H-loop/switch region; other site 83332000562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332000563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332000564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332000565 Walker A/P-loop; other site 83332000566 ATP binding site [chemical binding]; other site 83332000567 Q-loop/lid; other site 83332000568 ABC transporter signature motif; other site 83332000569 Walker B; other site 83332000570 D-loop; other site 83332000571 H-loop/switch region; other site 83332000572 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332000573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332000574 DNA binding residues [nucleotide binding] 83332000575 dimerization interface [polypeptide binding]; other site 83332000576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000578 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 83332000579 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 83332000580 putative [Fe4-S4] binding site [ion binding]; other site 83332000581 putative molybdopterin cofactor binding site [chemical binding]; other site 83332000582 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 83332000583 putative molybdopterin cofactor binding site; other site 83332000584 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 83332000585 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 83332000586 active site 83332000587 Zn binding site [ion binding]; other site 83332000588 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332000589 MMPL family; Region: MMPL; cl14618 83332000590 MMPL family; Region: MMPL; cl14618 83332000591 Predicted integral membrane protein [Function unknown]; Region: COG0392 83332000592 Domain of unknown function DUF20; Region: UPF0118; pfam01594 83332000593 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 83332000594 MMPL family; Region: MMPL; cl14618 83332000595 MMPL family; Region: MMPL; cl14618 83332000596 LabA_like proteins; Region: LabA_like; cd06167 83332000597 putative metal binding site [ion binding]; other site 83332000598 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 83332000599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000600 S-adenosylmethionine binding site [chemical binding]; other site 83332000601 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 83332000602 active site 83332000603 substrate-binding site [chemical binding]; other site 83332000604 metal-binding site [ion binding] 83332000605 GTP binding site [chemical binding]; other site 83332000606 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 83332000607 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 83332000608 active site 83332000609 (T/H)XGH motif; other site 83332000610 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 83332000611 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 83332000612 Radical SAM superfamily; Region: Radical_SAM; pfam04055 83332000613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332000614 FeS/SAM binding site; other site 83332000615 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 83332000616 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332000617 acyl-activating enzyme (AAE) consensus motif; other site 83332000618 putative AMP binding site [chemical binding]; other site 83332000619 putative active site [active] 83332000620 putative CoA binding site [chemical binding]; other site 83332000621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000623 active site 83332000624 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 83332000625 putative active site [active] 83332000626 putative catalytic site [active] 83332000627 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332000628 active site 2 [active] 83332000629 active site 1 [active] 83332000630 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332000631 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332000632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 83332000633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 83332000634 Moco binding site; other site 83332000635 metal coordination site [ion binding]; other site 83332000636 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332000637 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332000638 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332000639 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332000640 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332000641 enoyl-CoA hydratase; Provisional; Region: PRK08252 83332000642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332000643 substrate binding site [chemical binding]; other site 83332000644 oxyanion hole (OAH) forming residues; other site 83332000645 trimer interface [polypeptide binding]; other site 83332000646 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 83332000647 NAD binding site [chemical binding]; other site 83332000648 catalytic residues [active] 83332000649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000650 S-adenosylmethionine binding site [chemical binding]; other site 83332000651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332000652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332000653 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 83332000654 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332000655 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332000656 putative active site [active] 83332000657 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 83332000658 active site 83332000659 substrate binding pocket [chemical binding]; other site 83332000660 homodimer interaction site [polypeptide binding]; other site 83332000661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000663 active site 83332000664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000666 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 83332000667 active site 83332000668 diiron metal binding site [ion binding]; other site 83332000669 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 83332000670 NAD(P) binding site [chemical binding]; other site 83332000671 catalytic residues [active] 83332000672 Lipase maturation factor; Region: LMF1; pfam06762 83332000673 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 83332000674 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 83332000675 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 83332000676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000678 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332000679 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332000680 MaoC like domain; Region: MaoC_dehydratas; pfam01575 83332000681 active site 2 [active] 83332000682 active site 1 [active] 83332000683 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 83332000684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332000685 NAD(P) binding site [chemical binding]; other site 83332000686 active site 83332000687 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 83332000688 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332000689 dimer interface [polypeptide binding]; other site 83332000690 active site 83332000691 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 83332000692 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 83332000693 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 83332000694 FAD binding site [chemical binding]; other site 83332000695 substrate binding site [chemical binding]; other site 83332000696 catalytic residues [active] 83332000697 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 83332000698 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 83332000699 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 83332000700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332000701 catalytic loop [active] 83332000702 iron binding site [ion binding]; other site 83332000703 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 83332000704 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 83332000705 L-aspartate oxidase; Provisional; Region: PRK06175 83332000706 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332000707 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 83332000708 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 83332000709 putative dimer interface [polypeptide binding]; other site 83332000710 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 83332000711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332000712 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 83332000713 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332000714 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 83332000715 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 83332000716 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]; Region: CobU; COG2087 83332000717 cobyric acid synthase; Provisional; Region: PRK00784 83332000718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332000719 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 83332000720 catalytic triad [active] 83332000721 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000722 PPE family; Region: PPE; pfam00823 83332000723 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 83332000724 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 83332000725 putative active site [active] 83332000726 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 83332000727 putative active site [active] 83332000728 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 83332000729 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 83332000730 active site 83332000731 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 83332000732 DNA binding site [nucleotide binding] 83332000733 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 83332000734 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332000735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332000736 Coenzyme A binding pocket [chemical binding]; other site 83332000737 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 83332000738 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 83332000739 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 83332000740 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 83332000741 intersubunit interface [polypeptide binding]; other site 83332000742 5-oxoprolinase; Region: PLN02666 83332000743 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 83332000744 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 83332000745 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 83332000746 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332000747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332000748 putative substrate translocation pore; other site 83332000749 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332000750 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 83332000751 nucleotide binding site [chemical binding]; other site 83332000752 acyl-CoA synthetase; Validated; Region: PRK07788 83332000753 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332000755 acyl-activating enzyme (AAE) consensus motif; other site 83332000756 acyl-activating enzyme (AAE) consensus motif; other site 83332000757 AMP binding site [chemical binding]; other site 83332000758 active site 83332000759 active site 83332000760 AMP binding site [chemical binding]; other site 83332000761 CoA binding site [chemical binding]; other site 83332000762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332000764 active site 83332000765 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332000766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332000767 FAD binding site [chemical binding]; other site 83332000768 substrate binding site [chemical binding]; other site 83332000769 catalytic base [active] 83332000770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000773 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 83332000774 Zn binding site [ion binding]; other site 83332000775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332000777 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332000778 putative active site [active] 83332000779 Rv0277A, len: 85 aa. Possible vapB25, antitoxin,part of toxin-antitoxin (TA) operon with Rv0277c, see Arcus et al. 2005. Has in-frame stop codon so may not be expressed. Very similar to others in Mycobacterium tuberculosis e.g. Rv0748 (85 aa). Fasta score E(): 4e-24; 88.2% identity in 85 aa overlap 83332000780 PE family; Region: PE; pfam00934 83332000781 PE family; Region: PE; pfam00934 83332000782 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000783 PPE family; Region: PPE; pfam00823 83332000784 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332000785 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332000786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 83332000787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332000788 Walker A motif; other site 83332000789 ATP binding site [chemical binding]; other site 83332000790 Walker B motif; other site 83332000791 arginine finger; other site 83332000792 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332000793 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000795 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332000796 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332000798 PE family; Region: PE; pfam00934 83332000799 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000800 PPE family; Region: PPE; pfam00823 83332000801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332000802 EspG family; Region: ESX-1_EspG; pfam14011 83332000803 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332000804 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332000805 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332000806 active site 83332000807 catalytic residues [active] 83332000808 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332000809 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332000810 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 83332000811 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 83332000812 FtsJ-like methyltransferase; Region: FtsJ; cl17430 83332000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000814 S-adenosylmethionine binding site [chemical binding]; other site 83332000815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 83332000816 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332000817 Sulfatase; Region: Sulfatase; pfam00884 83332000818 PE family; Region: PE; pfam00934 83332000819 hypothetical protein; Region: PHA01748 83332000820 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332000821 putative active site [active] 83332000822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000824 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 83332000825 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 83332000826 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 83332000827 putative NAD(P) binding site [chemical binding]; other site 83332000828 active site 83332000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000830 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000831 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000833 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000835 BDLF3; Provisional; Region: PHA03255 83332000836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000837 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000841 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000843 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000844 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000847 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000849 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000850 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000851 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000852 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000853 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000854 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000855 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000856 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000857 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000858 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000859 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000860 PPE family; Region: PPE; pfam00823 83332000861 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000862 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000863 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000864 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000865 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000866 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000867 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000868 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000869 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000870 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000871 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000872 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332000873 FMN binding site [chemical binding]; other site 83332000874 dimer interface [polypeptide binding]; other site 83332000875 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 83332000876 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 83332000877 active site 83332000878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 83332000879 SnoaL-like domain; Region: SnoaL_4; pfam13577 83332000880 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 83332000881 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332000882 nucleotide binding site [chemical binding]; other site 83332000883 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 83332000884 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332000885 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 83332000886 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 83332000887 active site 83332000888 catalytic residues [active] 83332000889 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 83332000890 Muconolactone delta-isomerase; Region: MIase; cl01992 83332000891 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 83332000892 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332000893 putative active site [active] 83332000894 catalytic site [active] 83332000895 putative metal binding site [ion binding]; other site 83332000896 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 83332000897 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 83332000898 putative substrate binding pocket [chemical binding]; other site 83332000899 AC domain interface; other site 83332000900 catalytic triad [active] 83332000901 AB domain interface; other site 83332000902 interchain disulfide; other site 83332000903 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 83332000904 trimer interface [polypeptide binding]; other site 83332000905 active site 83332000906 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 83332000907 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 83332000908 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 83332000909 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 83332000910 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 83332000911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332000912 dimerization interface [polypeptide binding]; other site 83332000913 putative DNA binding site [nucleotide binding]; other site 83332000914 putative Zn2+ binding site [ion binding]; other site 83332000915 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332000916 active site residue [active] 83332000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000918 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332000919 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 83332000920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000921 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 83332000922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332000923 S-adenosylmethionine binding site [chemical binding]; other site 83332000924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332000925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332000926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 83332000927 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332000928 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332000929 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 83332000930 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332000931 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 83332000932 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 83332000933 substrate binding site; other site 83332000934 tetramer interface; other site 83332000935 PE family; Region: PE; pfam00934 83332000936 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332000937 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332000938 active site 83332000939 aminotransferase AlaT; Validated; Region: PRK09265 83332000940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332000941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332000942 homodimer interface [polypeptide binding]; other site 83332000943 catalytic residue [active] 83332000944 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 83332000945 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 83332000946 Cysteine-rich domain; Region: CCG; pfam02754 83332000947 Cysteine-rich domain; Region: CCG; pfam02754 83332000948 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 83332000949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332000950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332000951 DNA binding residues [nucleotide binding] 83332000952 dimerization interface [polypeptide binding]; other site 83332000953 EBNA-3A; Provisional; Region: PHA03379 83332000954 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 83332000955 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000956 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000957 G3 box; other site 83332000958 Switch II region; other site 83332000959 GTP/Mg2+ binding site [chemical binding]; other site 83332000960 G4 box; other site 83332000961 G5 box; other site 83332000962 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 83332000963 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332000964 G1 box; other site 83332000965 GTP/Mg2+ binding site [chemical binding]; other site 83332000966 G2 box; other site 83332000967 Switch I region; other site 83332000968 G3 box; other site 83332000969 Switch II region; other site 83332000970 G4 box; other site 83332000971 G5 box; other site 83332000972 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 83332000973 active site 83332000974 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332000975 TIGR04255 family protein; Region: sporadTIGR04255 83332000976 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 83332000977 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 83332000978 nucleotide binding site [chemical binding]; other site 83332000979 NEF interaction site [polypeptide binding]; other site 83332000980 SBD interface [polypeptide binding]; other site 83332000981 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 83332000982 dimer interface [polypeptide binding]; other site 83332000983 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 83332000984 chaperone protein DnaJ; Provisional; Region: PRK14279 83332000985 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 83332000986 HSP70 interaction site [polypeptide binding]; other site 83332000987 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 83332000988 Zn binding sites [ion binding]; other site 83332000989 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 83332000990 dimer interface [polypeptide binding]; other site 83332000991 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 83332000992 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 83332000993 DNA binding residues [nucleotide binding] 83332000994 putative dimer interface [polypeptide binding]; other site 83332000995 type II secretion system protein D; Region: type_II_gspD; TIGR02517 83332000996 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332000997 PPE family; Region: PPE; pfam00823 83332000998 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332000999 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001000 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001001 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001002 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001003 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001004 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001005 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001006 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001007 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001008 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001009 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001010 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001011 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001012 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001013 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001014 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001015 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001016 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001017 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001018 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001019 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001020 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001021 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001022 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001023 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001024 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001025 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001026 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001027 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001028 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001029 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001030 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001031 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001032 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001033 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001034 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001035 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001036 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001037 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001038 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001039 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332001040 CoenzymeA binding site [chemical binding]; other site 83332001041 subunit interaction site [polypeptide binding]; other site 83332001042 PHB binding site; other site 83332001043 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 83332001044 GDP-binding site [chemical binding]; other site 83332001045 ACT binding site; other site 83332001046 IMP binding site; other site 83332001047 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 83332001048 Peptidase family M50; Region: Peptidase_M50; pfam02163 83332001049 active site 83332001050 putative substrate binding region [chemical binding]; other site 83332001051 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 83332001052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332001053 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 83332001054 MgtE intracellular N domain; Region: MgtE_N; pfam03448 83332001055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 83332001056 Divalent cation transporter; Region: MgtE; pfam01769 83332001057 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 83332001058 active site 83332001059 intersubunit interface [polypeptide binding]; other site 83332001060 zinc binding site [ion binding]; other site 83332001061 Na+ binding site [ion binding]; other site 83332001062 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 83332001063 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 83332001064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 83332001065 AAA domain; Region: AAA_33; pfam13671 83332001066 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 83332001067 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 83332001068 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 83332001069 metal ion-dependent adhesion site (MIDAS); other site 83332001070 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 83332001071 putative hydrophobic ligand binding site [chemical binding]; other site 83332001072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 83332001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001074 Walker A motif; other site 83332001075 ATP binding site [chemical binding]; other site 83332001076 Walker B motif; other site 83332001077 arginine finger; other site 83332001078 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 83332001079 Ligand binding site; other site 83332001080 metal-binding site 83332001081 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 83332001082 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001083 XdhC Rossmann domain; Region: XdhC_C; pfam13478 83332001084 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 83332001085 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 83332001086 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 83332001087 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 83332001088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332001089 catalytic loop [active] 83332001090 iron binding site [ion binding]; other site 83332001091 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 83332001092 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 83332001093 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 83332001094 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 83332001095 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001096 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 83332001097 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 83332001098 XdhC Rossmann domain; Region: XdhC_C; pfam13478 83332001099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332001100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332001101 LysR substrate binding domain; Region: LysR_substrate; pfam03466 83332001102 dimerization interface [polypeptide binding]; other site 83332001103 Uncharacterized conserved protein [Function unknown]; Region: COG3360 83332001104 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332001105 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332001106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332001107 active site 83332001108 Proline-rich; Region: Pro-rich; pfam15240 83332001109 Clp amino terminal domain; Region: Clp_N; pfam02861 83332001110 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 83332001111 Clp amino terminal domain; Region: Clp_N; pfam02861 83332001112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001113 Walker A motif; other site 83332001114 ATP binding site [chemical binding]; other site 83332001115 Walker B motif; other site 83332001116 arginine finger; other site 83332001117 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 83332001118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001119 Walker A motif; other site 83332001120 ATP binding site [chemical binding]; other site 83332001121 Walker B motif; other site 83332001122 arginine finger; other site 83332001123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 83332001124 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 83332001125 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 83332001126 heme-binding site [chemical binding]; other site 83332001127 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 83332001128 FAD binding pocket [chemical binding]; other site 83332001129 FAD binding motif [chemical binding]; other site 83332001130 phosphate binding motif [ion binding]; other site 83332001131 beta-alpha-beta structure motif; other site 83332001132 NAD binding pocket [chemical binding]; other site 83332001133 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332001134 cyclase homology domain; Region: CHD; cd07302 83332001135 nucleotidyl binding site; other site 83332001136 metal binding site [ion binding]; metal-binding site 83332001137 dimer interface [polypeptide binding]; other site 83332001138 Predicted ATPase [General function prediction only]; Region: COG3903 83332001139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332001140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332001141 DNA binding residues [nucleotide binding] 83332001142 dimerization interface [polypeptide binding]; other site 83332001143 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001144 PPE family; Region: PPE; pfam00823 83332001145 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 83332001146 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 83332001147 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332001148 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 83332001149 active site residue [active] 83332001150 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332001151 homodimer interface [polypeptide binding]; other site 83332001152 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 83332001153 substrate-cofactor binding pocket; other site 83332001154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332001155 catalytic residue [active] 83332001156 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332001157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332001158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001159 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332001160 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332001161 active site 83332001162 PLD-like domain; Region: PLDc_2; pfam13091 83332001163 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332001164 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 83332001165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332001166 FAD binding site [chemical binding]; other site 83332001167 substrate binding pocket [chemical binding]; other site 83332001168 catalytic base [active] 83332001169 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 83332001170 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001171 MMPL family; Region: MMPL; pfam03176 83332001172 MMPL family; Region: MMPL; pfam03176 83332001173 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001174 acyl-CoA synthetase; Validated; Region: PRK05850 83332001175 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332001176 acyl-activating enzyme (AAE) consensus motif; other site 83332001177 active site 83332001178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332001179 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332001180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332001181 active site 83332001182 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332001183 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332001184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332001185 Thioesterase; Region: PKS_TE; smart00824 83332001186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332001187 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332001188 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332001189 phosphate acetyltransferase; Reviewed; Region: PRK05632 83332001190 DRTGG domain; Region: DRTGG; pfam07085 83332001191 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 83332001192 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 83332001193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332001194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332001195 active site 83332001196 ATP binding site [chemical binding]; other site 83332001197 substrate binding site [chemical binding]; other site 83332001198 activation loop (A-loop); other site 83332001199 Tetratricopeptide repeat; Region: TPR_16; pfam13432 83332001200 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 83332001201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 83332001202 substrate binding pocket [chemical binding]; other site 83332001203 membrane-bound complex binding site; other site 83332001204 hinge residues; other site 83332001205 NUDIX domain; Region: NUDIX; pfam00293 83332001206 nudix motif; other site 83332001207 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 83332001208 thiamine phosphate binding site [chemical binding]; other site 83332001209 active site 83332001210 pyrophosphate binding site [ion binding]; other site 83332001211 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 83332001212 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 83332001213 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 83332001214 thiS-thiF/thiG interaction site; other site 83332001215 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 83332001216 ThiS interaction site; other site 83332001217 putative active site [active] 83332001218 tetramer interface [polypeptide binding]; other site 83332001219 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 83332001220 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 83332001221 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 83332001222 PA/protease or protease-like domain interface [polypeptide binding]; other site 83332001223 active site 83332001224 metal binding site [ion binding]; metal-binding site 83332001225 Predicted metalloprotease [General function prediction only]; Region: COG2321 83332001226 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 83332001227 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332001228 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 83332001229 dimer interface [polypeptide binding]; other site 83332001230 substrate binding site [chemical binding]; other site 83332001231 ATP binding site [chemical binding]; other site 83332001232 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 83332001233 ThiC-associated domain; Region: ThiC-associated; pfam13667 83332001234 ThiC family; Region: ThiC; pfam01964 83332001235 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332001236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332001237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332001238 motif II; other site 83332001239 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332001240 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 83332001241 putative catalytic site [active] 83332001242 putative phosphate binding site [ion binding]; other site 83332001243 active site 83332001244 metal binding site A [ion binding]; metal-binding site 83332001245 DNA binding site [nucleotide binding] 83332001246 putative AP binding site [nucleotide binding]; other site 83332001247 putative metal binding site B [ion binding]; other site 83332001248 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 83332001249 active site 83332001250 catalytic residues [active] 83332001251 metal binding site [ion binding]; metal-binding site 83332001252 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 83332001253 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332001254 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 83332001255 E-class dimer interface [polypeptide binding]; other site 83332001256 P-class dimer interface [polypeptide binding]; other site 83332001257 active site 83332001258 Cu2+ binding site [ion binding]; other site 83332001259 Zn2+ binding site [ion binding]; other site 83332001260 carboxylate-amine ligase; Provisional; Region: PRK13517 83332001261 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 83332001262 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 83332001263 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 83332001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001265 Walker A motif; other site 83332001266 ATP binding site [chemical binding]; other site 83332001267 Walker B motif; other site 83332001268 arginine finger; other site 83332001269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332001270 Walker A motif; other site 83332001271 ATP binding site [chemical binding]; other site 83332001272 Walker B motif; other site 83332001273 arginine finger; other site 83332001274 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 83332001275 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 83332001276 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 83332001277 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 83332001278 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 83332001279 dimer interface [polypeptide binding]; other site 83332001280 putative functional site; other site 83332001281 putative MPT binding site; other site 83332001282 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332001283 short chain dehydrogenase; Provisional; Region: PRK12828 83332001284 putative NAD(P) binding site [chemical binding]; other site 83332001285 active site 83332001286 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 83332001287 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 83332001288 ring oligomerisation interface [polypeptide binding]; other site 83332001289 ATP/Mg binding site [chemical binding]; other site 83332001290 stacking interactions; other site 83332001291 hinge regions; other site 83332001292 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001293 PPE family; Region: PPE; pfam00823 83332001294 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001295 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332001296 Protein of unknown function (DUF664); Region: DUF664; pfam04978 83332001297 putative anti-sigmaE protein; Provisional; Region: PRK13920 83332001298 Anti-sigma-K factor rskA; Region: RskA; pfam10099 83332001299 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 83332001300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332001301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332001302 DNA binding residues [nucleotide binding] 83332001303 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 83332001304 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001306 S-adenosylmethionine binding site [chemical binding]; other site 83332001307 Uncharacterized conserved protein [Function unknown]; Region: COG3496 83332001308 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 83332001309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332001310 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 83332001311 dimer interface [polypeptide binding]; other site 83332001312 Transport protein; Region: actII; TIGR00833 83332001313 MMPL family; Region: MMPL; pfam03176 83332001314 MMPL family; Region: MMPL; pfam03176 83332001315 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001318 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332001319 PPE family; Region: PPE; pfam00823 83332001320 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 83332001321 enoyl-CoA hydratase; Provisional; Region: PRK12478 83332001322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001323 substrate binding site [chemical binding]; other site 83332001324 oxyanion hole (OAH) forming residues; other site 83332001325 trimer interface [polypeptide binding]; other site 83332001326 PemK-like protein; Region: PemK; pfam02452 83332001327 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 83332001328 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332001329 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 83332001330 NAD(P) binding site [chemical binding]; other site 83332001331 catalytic residues [active] 83332001332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 83332001333 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 83332001334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001336 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 83332001337 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332001338 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 83332001339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332001340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332001341 non-specific DNA binding site [nucleotide binding]; other site 83332001342 salt bridge; other site 83332001343 sequence-specific DNA binding site [nucleotide binding]; other site 83332001344 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 83332001345 Domain of unknown function (DUF955); Region: DUF955; pfam06114 83332001346 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 83332001347 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 83332001348 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332001349 active site 83332001350 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332001351 active site 2 [active] 83332001352 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 83332001353 oligomerization interface [polypeptide binding]; other site 83332001354 active site 83332001355 metal binding site [ion binding]; metal-binding site 83332001356 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 83332001357 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332001358 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332001359 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001362 S-adenosylmethionine binding site [chemical binding]; other site 83332001363 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001366 S-adenosylmethionine binding site [chemical binding]; other site 83332001367 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 83332001368 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 83332001369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001371 Predicted membrane protein [Function unknown]; Region: COG2733 83332001372 Protein of unknown function (DUF445); Region: DUF445; pfam04286 83332001373 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332001374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332001375 non-specific DNA binding site [nucleotide binding]; other site 83332001376 salt bridge; other site 83332001377 sequence-specific DNA binding site [nucleotide binding]; other site 83332001378 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 83332001379 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 83332001380 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 83332001381 intersubunit interface [polypeptide binding]; other site 83332001382 active site 83332001383 catalytic residue [active] 83332001384 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332001385 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 83332001386 putative active site [active] 83332001387 catalytic triad [active] 83332001388 putative dimer interface [polypeptide binding]; other site 83332001389 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 83332001390 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 83332001391 FAD binding domain; Region: FAD_binding_4; pfam01565 83332001392 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 83332001393 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 83332001394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332001395 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 83332001396 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332001397 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332001398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332001399 NAD(P) binding site [chemical binding]; other site 83332001400 active site 83332001401 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332001402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332001403 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 83332001404 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 83332001405 putative ADP-binding pocket [chemical binding]; other site 83332001406 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 83332001407 L-lysine exporter; Region: 2a75; TIGR00948 83332001408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332001409 catalytic core [active] 83332001410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332001411 dimer interface [polypeptide binding]; other site 83332001412 phosphorylation site [posttranslational modification] 83332001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332001414 ATP binding site [chemical binding]; other site 83332001415 Mg2+ binding site [ion binding]; other site 83332001416 G-X-G motif; other site 83332001417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332001418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332001419 active site 83332001420 phosphorylation site [posttranslational modification] 83332001421 intermolecular recognition site; other site 83332001422 dimerization interface [polypeptide binding]; other site 83332001423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332001424 DNA binding site [nucleotide binding] 83332001425 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 83332001426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001427 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 83332001428 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332001429 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332001430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332001431 DNA-binding site [nucleotide binding]; DNA binding site 83332001432 FCD domain; Region: FCD; pfam07729 83332001433 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 83332001434 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 83332001435 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 83332001436 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 83332001437 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 83332001438 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 83332001439 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 83332001440 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 83332001441 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 83332001442 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 83332001443 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332001444 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332001445 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 83332001446 putative NAD(P) binding site [chemical binding]; other site 83332001447 active site 83332001448 putative substrate binding site [chemical binding]; other site 83332001449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332001450 putative acyl-acceptor binding pocket; other site 83332001451 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001454 S-adenosylmethionine binding site [chemical binding]; other site 83332001455 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001456 active site 83332001457 catalytic site [active] 83332001458 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 83332001459 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 83332001460 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001461 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001462 MMPL family; Region: MMPL; pfam03176 83332001463 MMPL family; Region: MMPL; pfam03176 83332001464 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 83332001465 glutamyl-tRNA reductase; Region: hemA; TIGR01035 83332001466 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 83332001467 tRNA; other site 83332001468 putative tRNA binding site [nucleotide binding]; other site 83332001469 putative NADP binding site [chemical binding]; other site 83332001470 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 83332001471 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 83332001472 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 83332001473 domain interfaces; other site 83332001474 active site 83332001475 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 83332001476 active site 83332001477 homodimer interface [polypeptide binding]; other site 83332001478 SAM binding site [chemical binding]; other site 83332001479 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 83332001480 active site 83332001481 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 83332001482 dimer interface [polypeptide binding]; other site 83332001483 active site 83332001484 Schiff base residues; other site 83332001485 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332001486 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332001487 active site 83332001488 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332001489 anti sigma factor interaction site; other site 83332001490 regulatory phosphorylation site [posttranslational modification]; other site 83332001491 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332001492 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 83332001493 active site 83332001494 catalytic triad [active] 83332001495 oxyanion hole [active] 83332001496 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 83332001497 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332001498 S-formylglutathione hydrolase; Region: PLN02442 83332001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001500 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332001501 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332001502 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332001503 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 83332001504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332001505 inhibitor-cofactor binding pocket; inhibition site 83332001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332001507 catalytic residue [active] 83332001508 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 83332001509 catalytic core [active] 83332001510 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 83332001511 catalytic residues [active] 83332001512 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332001513 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 83332001514 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 83332001515 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332001516 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332001517 P-loop; other site 83332001518 Magnesium ion binding site [ion binding]; other site 83332001519 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332001520 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 83332001521 PE family; Region: PE; pfam00934 83332001522 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 83332001523 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 83332001524 dimer interface [polypeptide binding]; other site 83332001525 active site 83332001526 CoA binding pocket [chemical binding]; other site 83332001527 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 83332001528 putative active site [active] 83332001529 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 83332001530 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 83332001531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332001532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332001533 NAD(P) binding site [chemical binding]; other site 83332001534 active site 83332001535 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 83332001536 Ligand binding site; other site 83332001537 Putative Catalytic site; other site 83332001538 DXD motif; other site 83332001539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 83332001540 Phage-related tail protein [Function unknown]; Region: COG5283 83332001541 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 83332001542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332001543 acyl-activating enzyme (AAE) consensus motif; other site 83332001544 AMP binding site [chemical binding]; other site 83332001545 active site 83332001546 CoA binding site [chemical binding]; other site 83332001547 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 83332001548 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 83332001549 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 83332001550 active site 83332001551 short chain dehydrogenase; Provisional; Region: PRK05866 83332001552 classical (c) SDRs; Region: SDR_c; cd05233 83332001553 NAD(P) binding site [chemical binding]; other site 83332001554 active site 83332001555 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 83332001556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001557 substrate binding site [chemical binding]; other site 83332001558 oxyanion hole (OAH) forming residues; other site 83332001559 trimer interface [polypeptide binding]; other site 83332001560 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332001561 putative active site [active] 83332001562 homotetrameric interface [polypeptide binding]; other site 83332001563 metal binding site [ion binding]; metal-binding site 83332001564 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 83332001565 acyl-CoA synthetase; Validated; Region: PRK06188 83332001566 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332001567 putative active site [active] 83332001568 putative CoA binding site [chemical binding]; other site 83332001569 putative AMP binding site [chemical binding]; other site 83332001570 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 83332001571 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 83332001572 active site 83332001573 O-succinylbenzoate synthase; Provisional; Region: PRK02901 83332001574 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 83332001575 active site 83332001576 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332001577 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332001578 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332001579 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 83332001580 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 83332001581 dimer interface [polypeptide binding]; other site 83332001582 tetramer interface [polypeptide binding]; other site 83332001583 PYR/PP interface [polypeptide binding]; other site 83332001584 TPP binding site [chemical binding]; other site 83332001585 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 83332001586 TPP-binding site; other site 83332001587 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 83332001588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332001589 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 83332001590 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 83332001591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001592 S-adenosylmethionine binding site [chemical binding]; other site 83332001593 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332001594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001595 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332001596 S-adenosylmethionine binding site [chemical binding]; other site 83332001597 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 83332001598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001600 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332001601 substrate binding pocket [chemical binding]; other site 83332001602 chain length determination region; other site 83332001603 substrate-Mg2+ binding site; other site 83332001604 catalytic residues [active] 83332001605 aspartate-rich region 1; other site 83332001606 active site lid residues [active] 83332001607 aspartate-rich region 2; other site 83332001608 heat shock protein HtpX; Provisional; Region: PRK03072 83332001609 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 83332001610 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 83332001611 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 83332001612 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332001613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332001614 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 83332001615 O-methyltransferase; Region: Methyltransf_2; pfam00891 83332001616 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332001617 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 83332001618 ATP cone domain; Region: ATP-cone; pfam03477 83332001619 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 83332001620 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 83332001621 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 83332001622 active site 83332001623 dimer interface [polypeptide binding]; other site 83332001624 effector binding site; other site 83332001625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332001626 active site 83332001627 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332001628 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332001629 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 83332001630 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 83332001631 active site 83332001632 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 83332001633 putative active site [active] 83332001634 putative metal binding site [ion binding]; other site 83332001635 hypothetical protein; Provisional; Region: PRK07588 83332001636 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 83332001637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332001638 dimerization interface [polypeptide binding]; other site 83332001639 putative DNA binding site [nucleotide binding]; other site 83332001640 putative Zn2+ binding site [ion binding]; other site 83332001641 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 83332001642 putative hydrophobic ligand binding site [chemical binding]; other site 83332001643 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332001644 TIGR03086 family protein; Region: TIGR03086 83332001645 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332001646 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332001647 PE family; Region: PE; pfam00934 83332001648 Mut7-C ubiquitin; Region: Ub-Mut7C; pfam14451 83332001649 Mut7-C RNAse domain; Region: Mut7-C; pfam01927 83332001650 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332001651 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332001652 putative active site [active] 83332001653 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332001654 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 83332001655 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 83332001656 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 83332001657 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332001658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332001659 DNA-binding site [nucleotide binding]; DNA binding site 83332001660 FCD domain; Region: FCD; pfam07729 83332001661 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332001662 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332001663 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001664 mce related protein; Region: MCE; pfam02470 83332001665 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001666 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 83332001667 mce related protein; Region: MCE; pfam02470 83332001668 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001669 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001670 mce related protein; Region: MCE; pfam02470 83332001671 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001672 mce related protein; Region: MCE; pfam02470 83332001673 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332001674 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001675 mce related protein; Region: MCE; pfam02470 83332001676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332001677 mce related protein; Region: MCE; pfam02470 83332001678 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332001679 oligomeric interface; other site 83332001680 putative active site [active] 83332001681 homodimer interface [polypeptide binding]; other site 83332001682 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332001683 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332001684 AAA domain; Region: AAA_14; pfam13173 83332001685 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 83332001686 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332001687 putative active site [active] 83332001688 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 83332001689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332001690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332001691 ATP binding site [chemical binding]; other site 83332001692 Mg2+ binding site [ion binding]; other site 83332001693 G-X-G motif; other site 83332001694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332001695 dimerization interface [polypeptide binding]; other site 83332001696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332001698 active site 83332001699 phosphorylation site [posttranslational modification] 83332001700 intermolecular recognition site; other site 83332001701 dimerization interface [polypeptide binding]; other site 83332001702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332001703 DNA binding site [nucleotide binding] 83332001704 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332001705 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332001706 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332001707 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332001708 catalytic residues [active] 83332001709 catalytic nucleophile [active] 83332001710 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332001711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332001712 Probable transposase; Region: OrfB_IS605; pfam01385 83332001713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332001714 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332001715 putative active site [active] 83332001716 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 83332001717 SEC-C motif; Region: SEC-C; pfam02810 83332001718 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 83332001719 putative active site [active] 83332001720 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 83332001721 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 83332001722 nucleotide binding site/active site [active] 83332001723 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 83332001724 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 83332001725 HIT family signature motif; other site 83332001726 catalytic residue [active] 83332001727 galactokinase; Provisional; Region: PRK00555 83332001728 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 83332001729 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 83332001730 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 83332001731 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332001732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332001733 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332001734 putative active site [active] 83332001735 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332001736 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332001737 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332001738 oligomeric interface; other site 83332001739 putative active site [active] 83332001740 homodimer interface [polypeptide binding]; other site 83332001741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 83332001742 FIST N domain; Region: FIST; pfam08495 83332001743 FIST C domain; Region: FIST_C; pfam10442 83332001744 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 83332001745 AAA domain; Region: AAA_30; pfam13604 83332001746 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 83332001747 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 83332001748 Part of AAA domain; Region: AAA_19; pfam13245 83332001749 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 83332001750 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 83332001751 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 83332001752 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332001753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001754 substrate binding site [chemical binding]; other site 83332001755 oxyanion hole (OAH) forming residues; other site 83332001756 trimer interface [polypeptide binding]; other site 83332001757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 83332001758 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332001759 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 83332001760 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001761 active site 83332001762 catalytic site [active] 83332001763 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 83332001764 active site 83332001765 catalytic site [active] 83332001766 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332001767 active site 83332001768 catalytic site [active] 83332001769 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 83332001770 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 83332001771 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 83332001772 putative homodimer interface [polypeptide binding]; other site 83332001773 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 83332001774 heterodimer interface [polypeptide binding]; other site 83332001775 homodimer interface [polypeptide binding]; other site 83332001776 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 83332001777 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 83332001778 23S rRNA interface [nucleotide binding]; other site 83332001779 L7/L12 interface [polypeptide binding]; other site 83332001780 putative thiostrepton binding site; other site 83332001781 L25 interface [polypeptide binding]; other site 83332001782 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 83332001783 mRNA/rRNA interface [nucleotide binding]; other site 83332001784 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001787 S-adenosylmethionine binding site [chemical binding]; other site 83332001788 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001791 S-adenosylmethionine binding site [chemical binding]; other site 83332001792 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001795 S-adenosylmethionine binding site [chemical binding]; other site 83332001796 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332001797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332001798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332001799 S-adenosylmethionine binding site [chemical binding]; other site 83332001800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332001801 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332001802 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 83332001803 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 83332001804 active site 83332001805 ATP binding site [chemical binding]; other site 83332001806 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 83332001807 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 83332001808 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 83332001809 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 83332001810 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 83332001811 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332001812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 83332001813 nucleotide binding site [chemical binding]; other site 83332001814 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 83332001815 23S rRNA interface [nucleotide binding]; other site 83332001816 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 83332001817 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 83332001818 core dimer interface [polypeptide binding]; other site 83332001819 peripheral dimer interface [polypeptide binding]; other site 83332001820 L10 interface [polypeptide binding]; other site 83332001821 L11 interface [polypeptide binding]; other site 83332001822 putative EF-Tu interaction site [polypeptide binding]; other site 83332001823 putative EF-G interaction site [polypeptide binding]; other site 83332001824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001826 WHG domain; Region: WHG; pfam13305 83332001827 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 83332001828 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 83332001829 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 83332001830 Walker A/P-loop; other site 83332001831 ATP binding site [chemical binding]; other site 83332001832 Q-loop/lid; other site 83332001833 ABC transporter signature motif; other site 83332001834 Walker B; other site 83332001835 D-loop; other site 83332001836 H-loop/switch region; other site 83332001837 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332001838 putative active site [active] 83332001839 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332001840 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 83332001841 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332001842 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 83332001843 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332001844 Sulfatase; Region: Sulfatase; pfam00884 83332001845 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 83332001846 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332001847 putative active site [active] 83332001848 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 83332001849 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 83332001850 RPB12 interaction site [polypeptide binding]; other site 83332001851 RPB1 interaction site [polypeptide binding]; other site 83332001852 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 83332001853 RPB10 interaction site [polypeptide binding]; other site 83332001854 RPB11 interaction site [polypeptide binding]; other site 83332001855 RPB3 interaction site [polypeptide binding]; other site 83332001856 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 83332001857 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 83332001858 beta and beta' interface [polypeptide binding]; other site 83332001859 beta' and sigma factor interface [polypeptide binding]; other site 83332001860 Zn-binding [ion binding]; other site 83332001861 active site region [active] 83332001862 catalytic site [active] 83332001863 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 83332001864 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 83332001865 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 83332001866 G-loop; other site 83332001867 DNA binding site [nucleotide binding] 83332001868 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 83332001869 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 83332001870 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 83332001871 AP (apurinic/apyrimidinic) site pocket; other site 83332001872 DNA interaction; other site 83332001873 Metal-binding active site; metal-binding site 83332001874 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 83332001875 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 83332001876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332001877 active site 83332001878 enoyl-CoA hydratase; Provisional; Region: PRK08272 83332001879 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001880 substrate binding site [chemical binding]; other site 83332001881 oxyanion hole (OAH) forming residues; other site 83332001882 trimer interface [polypeptide binding]; other site 83332001883 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 83332001884 PaaX-like protein; Region: PaaX; pfam07848 83332001885 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 83332001886 enoyl-CoA hydratase; Provisional; Region: PRK08259 83332001887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332001888 substrate binding site [chemical binding]; other site 83332001889 oxyanion hole (OAH) forming residues; other site 83332001890 trimer interface [polypeptide binding]; other site 83332001891 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332001892 MMPL family; Region: MMPL; pfam03176 83332001893 MMPL family; Region: MMPL; pfam03176 83332001894 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332001895 MarR family; Region: MarR_2; cl17246 83332001896 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332001897 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 83332001898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332001899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001900 WHG domain; Region: WHG; pfam13305 83332001901 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 83332001902 S17 interaction site [polypeptide binding]; other site 83332001903 S8 interaction site; other site 83332001904 16S rRNA interaction site [nucleotide binding]; other site 83332001905 streptomycin interaction site [chemical binding]; other site 83332001906 23S rRNA interaction site [nucleotide binding]; other site 83332001907 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 83332001908 30S ribosomal protein S7; Validated; Region: PRK05302 83332001909 elongation factor G; Reviewed; Region: PRK00007 83332001910 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 83332001911 G1 box; other site 83332001912 putative GEF interaction site [polypeptide binding]; other site 83332001913 GTP/Mg2+ binding site [chemical binding]; other site 83332001914 Switch I region; other site 83332001915 G2 box; other site 83332001916 G3 box; other site 83332001917 Switch II region; other site 83332001918 G4 box; other site 83332001919 G5 box; other site 83332001920 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 83332001921 Elongation Factor G, domain II; Region: EFG_II; pfam14492 83332001922 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 83332001923 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 83332001924 elongation factor Tu; Reviewed; Region: PRK00049 83332001925 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 83332001926 G1 box; other site 83332001927 GEF interaction site [polypeptide binding]; other site 83332001928 GTP/Mg2+ binding site [chemical binding]; other site 83332001929 Switch I region; other site 83332001930 G2 box; other site 83332001931 G3 box; other site 83332001932 Switch II region; other site 83332001933 G4 box; other site 83332001934 G5 box; other site 83332001935 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 83332001936 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 83332001937 Antibiotic Binding Site [chemical binding]; other site 83332001938 Short C-terminal domain; Region: SHOCT; pfam09851 83332001939 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 83332001940 classical (c) SDRs; Region: SDR_c; cd05233 83332001941 NAD(P) binding site [chemical binding]; other site 83332001942 active site 83332001943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 83332001944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332001945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001946 Reductase C-terminal; Region: Reductase_C; pfam14759 83332001947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 83332001948 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 83332001949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332001950 mycofactocin precursor; Region: mycofactocin; TIGR03969 83332001951 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 83332001952 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 83332001953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332001954 FeS/SAM binding site; other site 83332001955 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 83332001956 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 83332001957 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 83332001958 active site 83332001959 substrate binding site [chemical binding]; other site 83332001960 FMN binding site [chemical binding]; other site 83332001961 putative catalytic residues [active] 83332001962 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 83332001963 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 83332001964 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 83332001965 active site 83332001966 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 83332001967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332001968 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332001969 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 83332001970 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 83332001971 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 83332001972 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 83332001973 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 83332001974 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 83332001975 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 83332001976 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 83332001977 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 83332001978 putative translocon binding site; other site 83332001979 protein-rRNA interface [nucleotide binding]; other site 83332001980 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 83332001981 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 83332001982 G-X-X-G motif; other site 83332001983 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 83332001984 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 83332001985 23S rRNA interface [nucleotide binding]; other site 83332001986 5S rRNA interface [nucleotide binding]; other site 83332001987 putative antibiotic binding site [chemical binding]; other site 83332001988 L25 interface [polypeptide binding]; other site 83332001989 L27 interface [polypeptide binding]; other site 83332001990 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 83332001991 putative translocon interaction site; other site 83332001992 23S rRNA interface [nucleotide binding]; other site 83332001993 signal recognition particle (SRP54) interaction site; other site 83332001994 L23 interface [polypeptide binding]; other site 83332001995 trigger factor interaction site; other site 83332001996 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 83332001997 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332001998 Sulfatase; Region: Sulfatase; pfam00884 83332001999 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 83332002000 Uncharacterized conserved protein [Function unknown]; Region: COG1262 83332002001 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 83332002002 Domain of unknown function (DUF4436); Region: DUF4436; pfam14494 83332002003 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 83332002004 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 83332002005 RNA binding site [nucleotide binding]; other site 83332002006 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 83332002007 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 83332002008 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 83332002009 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 83332002010 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 83332002011 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 83332002012 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 83332002013 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 83332002014 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 83332002015 5S rRNA interface [nucleotide binding]; other site 83332002016 L27 interface [polypeptide binding]; other site 83332002017 23S rRNA interface [nucleotide binding]; other site 83332002018 L5 interface [polypeptide binding]; other site 83332002019 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 83332002020 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 83332002021 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 83332002022 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 83332002023 23S rRNA binding site [nucleotide binding]; other site 83332002024 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 83332002025 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 83332002026 tandem repeat interface [polypeptide binding]; other site 83332002027 oligomer interface [polypeptide binding]; other site 83332002028 active site residues [active] 83332002029 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 83332002030 tandem repeat interface [polypeptide binding]; other site 83332002031 oligomer interface [polypeptide binding]; other site 83332002032 active site residues [active] 83332002033 Leucine carboxyl methyltransferase; Region: LCM; cl01306 83332002034 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332002035 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332002036 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 83332002037 intersubunit interface [polypeptide binding]; other site 83332002038 active site 83332002039 Zn2+ binding site [ion binding]; other site 83332002040 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 83332002041 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 83332002042 NAD binding site [chemical binding]; other site 83332002043 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 83332002044 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332002045 nucleotide binding site [chemical binding]; other site 83332002046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332002047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002048 Coenzyme A binding pocket [chemical binding]; other site 83332002049 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332002050 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 83332002051 SecY translocase; Region: SecY; pfam00344 83332002052 adenylate kinase; Reviewed; Region: adk; PRK00279 83332002053 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 83332002054 AMP-binding site [chemical binding]; other site 83332002055 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 83332002056 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 83332002057 active site 83332002058 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 83332002059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332002060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332002061 DNA binding residues [nucleotide binding] 83332002062 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 83332002063 Putative zinc-finger; Region: zf-HC2; pfam13490 83332002064 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332002065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332002066 putative DNA binding site [nucleotide binding]; other site 83332002067 putative Zn2+ binding site [ion binding]; other site 83332002068 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332002069 TIGR03086 family protein; Region: TIGR03086 83332002070 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 83332002071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332002072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332002073 PE family; Region: PE; pfam00934 83332002074 Helix-turn-helix domain; Region: HTH_17; pfam12728 83332002075 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 83332002076 PE family; Region: PE; pfam00934 83332002077 PE family; Region: PE; pfam00934 83332002078 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332002079 putative active site [active] 83332002080 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 83332002081 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 83332002082 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 83332002083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002085 active site 83332002086 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 83332002087 tetrameric interface [polypeptide binding]; other site 83332002088 NAD binding site [chemical binding]; other site 83332002089 catalytic residues [active] 83332002090 PE family; Region: PE; pfam00934 83332002091 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 83332002092 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002093 PPE family; Region: PPE; pfam00823 83332002094 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002095 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002096 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002097 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002098 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002099 Helix-turn-helix domain; Region: HTH_28; pfam13518 83332002100 Winged helix-turn helix; Region: HTH_29; pfam13551 83332002101 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 83332002102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002104 active site 83332002105 phosphorylation site [posttranslational modification] 83332002106 intermolecular recognition site; other site 83332002107 dimerization interface [polypeptide binding]; other site 83332002108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002109 DNA binding site [nucleotide binding] 83332002110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002112 dimerization interface [polypeptide binding]; other site 83332002113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002114 dimer interface [polypeptide binding]; other site 83332002115 phosphorylation site [posttranslational modification] 83332002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002117 ATP binding site [chemical binding]; other site 83332002118 Mg2+ binding site [ion binding]; other site 83332002119 G-X-G motif; other site 83332002120 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 83332002121 nucleotide binding site/active site [active] 83332002122 HIT family signature motif; other site 83332002123 catalytic residue [active] 83332002124 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 83332002125 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 83332002126 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332002127 NAD binding site [chemical binding]; other site 83332002128 catalytic Zn binding site [ion binding]; other site 83332002129 substrate binding site [chemical binding]; other site 83332002130 structural Zn binding site [ion binding]; other site 83332002131 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 83332002132 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332002133 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002134 short chain dehydrogenase; Provisional; Region: PRK07775 83332002135 classical (c) SDRs; Region: SDR_c; cd05233 83332002136 NAD(P) binding site [chemical binding]; other site 83332002137 active site 83332002138 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332002141 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 83332002142 NAD binding site [chemical binding]; other site 83332002143 catalytic residues [active] 83332002144 short chain dehydrogenase; Provisional; Region: PRK07774 83332002145 classical (c) SDRs; Region: SDR_c; cd05233 83332002146 NAD(P) binding site [chemical binding]; other site 83332002147 active site 83332002148 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 83332002149 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 83332002150 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 83332002151 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 83332002152 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 83332002153 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 83332002154 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 83332002155 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 83332002156 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 83332002157 Predicted esterase [General function prediction only]; Region: COG0627 83332002158 S-formylglutathione hydrolase; Region: PLN02442 83332002159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 83332002160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332002161 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 83332002162 adenylosuccinate lyase; Region: purB; TIGR00928 83332002163 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 83332002164 tetramer interface [polypeptide binding]; other site 83332002165 active site 83332002166 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332002167 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 83332002168 ATP binding site [chemical binding]; other site 83332002169 active site 83332002170 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 83332002171 substrate binding site [chemical binding]; other site 83332002172 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 83332002173 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 83332002174 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 83332002175 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332002176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002177 putative substrate translocation pore; other site 83332002178 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 83332002179 putative active site [active] 83332002180 putative Zn binding site [ion binding]; other site 83332002181 Predicted oxidoreductase [General function prediction only]; Region: COG3573 83332002182 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 83332002183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 83332002184 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 83332002185 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 83332002186 putative active site [active] 83332002187 catalytic triad [active] 83332002188 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 83332002189 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332002190 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332002191 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 83332002192 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332002193 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332002194 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 83332002195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332002196 DNA-binding site [nucleotide binding]; DNA binding site 83332002197 UTRA domain; Region: UTRA; pfam07702 83332002198 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332002199 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 83332002200 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 83332002201 NAD binding site [chemical binding]; other site 83332002202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332002203 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 83332002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332002205 Transposase; Region: HTH_Tnp_1; cl17663 83332002206 putative transposase OrfB; Reviewed; Region: PHA02517 83332002207 HTH-like domain; Region: HTH_21; pfam13276 83332002208 Integrase core domain; Region: rve; pfam00665 83332002209 Integrase core domain; Region: rve_3; pfam13683 83332002210 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332002211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332002212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332002213 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 83332002214 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 83332002215 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 83332002216 active site 83332002217 metal binding site [ion binding]; metal-binding site 83332002218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 83332002219 active site 83332002220 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 83332002221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332002222 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 83332002223 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 83332002224 dimerization interface [polypeptide binding]; other site 83332002225 ATP binding site [chemical binding]; other site 83332002226 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 83332002227 dimerization interface [polypeptide binding]; other site 83332002228 ATP binding site [chemical binding]; other site 83332002229 CAAX protease self-immunity; Region: Abi; pfam02517 83332002230 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332002231 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 83332002232 active site 83332002233 metal binding site [ion binding]; metal-binding site 83332002234 hexamer interface [polypeptide binding]; other site 83332002235 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 83332002236 amidophosphoribosyltransferase; Provisional; Region: PRK07847 83332002237 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 83332002238 active site 83332002239 tetramer interface [polypeptide binding]; other site 83332002240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332002241 active site 83332002242 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 83332002243 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 83332002244 dimerization interface [polypeptide binding]; other site 83332002245 putative ATP binding site [chemical binding]; other site 83332002246 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 83332002247 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 83332002248 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 83332002249 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 83332002250 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 83332002251 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 83332002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002253 catalytic residue [active] 83332002254 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 83332002255 heme-binding site [chemical binding]; other site 83332002256 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 83332002257 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332002258 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332002259 active site residue [active] 83332002260 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332002261 active site residue [active] 83332002262 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332002263 catalytic residues [active] 83332002264 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332002265 DNA-binding response regulator CreB; Provisional; Region: PRK11083 83332002266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002267 DNA binding site [nucleotide binding] 83332002268 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 83332002269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002270 Coenzyme A binding pocket [chemical binding]; other site 83332002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002272 Coenzyme A binding pocket [chemical binding]; other site 83332002273 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 83332002274 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 83332002275 Walker A/P-loop; other site 83332002276 ATP binding site [chemical binding]; other site 83332002277 Q-loop/lid; other site 83332002278 ABC transporter signature motif; other site 83332002279 Walker B; other site 83332002280 D-loop; other site 83332002281 H-loop/switch region; other site 83332002282 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 83332002283 PhoU domain; Region: PhoU; pfam01895 83332002284 PhoU domain; Region: PhoU; pfam01895 83332002285 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 83332002286 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332002287 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 83332002288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 83332002289 FMN binding site [chemical binding]; other site 83332002290 active site 83332002291 catalytic residues [active] 83332002292 substrate binding site [chemical binding]; other site 83332002293 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 83332002294 homodimer interface [polypeptide binding]; other site 83332002295 putative substrate binding pocket [chemical binding]; other site 83332002296 diiron center [ion binding]; other site 83332002297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002298 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 83332002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332002300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332002301 dimerization interface [polypeptide binding]; other site 83332002302 putative DNA binding site [nucleotide binding]; other site 83332002303 putative Zn2+ binding site [ion binding]; other site 83332002304 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 83332002305 active site 83332002306 Zn binding site [ion binding]; other site 83332002307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332002308 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 83332002309 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332002310 TIGR04255 family protein; Region: sporadTIGR04255 83332002311 PE family; Region: PE; pfam00934 83332002312 PE family; Region: PE; pfam00934 83332002313 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332002314 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 83332002315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 83332002316 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 83332002317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332002318 S-adenosylmethionine binding site [chemical binding]; other site 83332002319 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 83332002320 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332002321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332002323 putative substrate translocation pore; other site 83332002324 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 83332002325 tetramer interface [polypeptide binding]; other site 83332002326 TPP-binding site [chemical binding]; other site 83332002327 heterodimer interface [polypeptide binding]; other site 83332002328 phosphorylation loop region [posttranslational modification] 83332002329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332002330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002331 active site 83332002332 phosphorylation site [posttranslational modification] 83332002333 intermolecular recognition site; other site 83332002334 dimerization interface [polypeptide binding]; other site 83332002335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332002336 DNA binding residues [nucleotide binding] 83332002337 dimerization interface [polypeptide binding]; other site 83332002338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002340 ATP binding site [chemical binding]; other site 83332002341 Mg2+ binding site [ion binding]; other site 83332002342 G-X-G motif; other site 83332002343 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 83332002344 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 83332002345 putative Domain 2 interface [polypeptide binding]; other site 83332002346 putative Domain 3 interface [polypeptide binding]; other site 83332002347 trinuclear Cu binding site [ion binding]; other site 83332002348 The second cupredoxin domain of CopA copper resistance protein like family; Region: CuRO_2_CopA_like_1; cd13870 83332002349 putative Domain 1 interface [polypeptide binding]; other site 83332002350 putative Domain 3 interface [polypeptide binding]; other site 83332002351 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 83332002352 putative Domain 2 interface [polypeptide binding]; other site 83332002353 Type 1 (T1) Cu binding site [ion binding]; other site 83332002354 putative Domain 1 interface [polypeptide binding]; other site 83332002355 trinuclear Cu binding site [ion binding]; other site 83332002356 cysteine synthase; Region: PLN02565 83332002357 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332002358 dimer interface [polypeptide binding]; other site 83332002359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002360 catalytic residue [active] 83332002361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002362 multidrug resistance protein MdtH; Provisional; Region: PRK11646 83332002363 putative substrate translocation pore; other site 83332002364 hypothetical protein; Provisional; Region: PRK06194 83332002365 classical (c) SDRs; Region: SDR_c; cd05233 83332002366 NAD(P) binding site [chemical binding]; other site 83332002367 active site 83332002368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332002369 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 83332002370 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 83332002371 dimer interface [polypeptide binding]; other site 83332002372 PYR/PP interface [polypeptide binding]; other site 83332002373 TPP binding site [chemical binding]; other site 83332002374 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332002375 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 83332002376 TPP-binding site [chemical binding]; other site 83332002377 dimer interface [polypeptide binding]; other site 83332002378 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002379 putative hydrophobic ligand binding site [chemical binding]; other site 83332002380 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332002381 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002382 putative hydrophobic ligand binding site [chemical binding]; other site 83332002383 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332002384 putative hydrophobic ligand binding site [chemical binding]; other site 83332002385 aminotransferase; Validated; Region: PRK07777 83332002386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332002387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332002388 homodimer interface [polypeptide binding]; other site 83332002389 catalytic residue [active] 83332002390 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 83332002391 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332002392 dimer interface [polypeptide binding]; other site 83332002393 active site 83332002394 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 83332002395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002396 substrate binding site [chemical binding]; other site 83332002397 oxyanion hole (OAH) forming residues; other site 83332002398 trimer interface [polypeptide binding]; other site 83332002399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332002400 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332002401 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 83332002402 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332002403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332002404 ATP binding site [chemical binding]; other site 83332002405 putative Mg++ binding site [ion binding]; other site 83332002406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332002407 nucleotide binding region [chemical binding]; other site 83332002408 ATP-binding site [chemical binding]; other site 83332002409 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 83332002410 WYL domain; Region: WYL; pfam13280 83332002411 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332002412 trimer interface [polypeptide binding]; other site 83332002413 dimer interface [polypeptide binding]; other site 83332002414 putative active site [active] 83332002415 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 83332002416 MPT binding site; other site 83332002417 trimer interface [polypeptide binding]; other site 83332002418 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332002419 MoaE homodimer interface [polypeptide binding]; other site 83332002420 MoaD interaction [polypeptide binding]; other site 83332002421 active site residues [active] 83332002422 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332002423 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332002424 MoaE interaction surface [polypeptide binding]; other site 83332002425 MoeB interaction surface [polypeptide binding]; other site 83332002426 thiocarboxylated glycine; other site 83332002427 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 83332002428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332002429 FeS/SAM binding site; other site 83332002430 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 83332002431 hypothetical protein; Provisional; Region: PRK11770 83332002432 Domain of unknown function (DUF307); Region: DUF307; pfam03733 83332002433 Domain of unknown function (DUF307); Region: DUF307; pfam03733 83332002434 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 83332002435 DNA-binding site [nucleotide binding]; DNA binding site 83332002436 RNA-binding motif; other site 83332002437 PE family; Region: PE; pfam00934 83332002438 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002440 active site 83332002441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 83332002442 FIST N domain; Region: FIST; pfam08495 83332002443 FIST C domain; Region: FIST_C; pfam10442 83332002444 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 83332002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332002446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332002447 putative substrate translocation pore; other site 83332002448 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 83332002449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002450 PPE family; Region: PPE; pfam00823 83332002451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002452 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002453 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332002454 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 83332002455 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332002456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332002457 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332002458 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332002459 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 83332002460 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 83332002461 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 83332002462 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332002463 catalytic residue [active] 83332002464 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 83332002465 Ferredoxin [Energy production and conversion]; Region: COG1146 83332002466 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 83332002467 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 83332002468 ferredoxin-NADP+ reductase; Region: PLN02852 83332002469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332002470 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 83332002471 putative dimer interface [polypeptide binding]; other site 83332002472 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 83332002473 putative catalytic site [active] 83332002474 putative phosphate binding site [ion binding]; other site 83332002475 putative metal binding site [ion binding]; other site 83332002476 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 83332002477 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 83332002478 dimer interface [polypeptide binding]; other site 83332002479 active site 83332002480 citrylCoA binding site [chemical binding]; other site 83332002481 oxalacetate/citrate binding site [chemical binding]; other site 83332002482 coenzyme A binding site [chemical binding]; other site 83332002483 catalytic triad [active] 83332002484 Predicted ATPase [General function prediction only]; Region: COG3903 83332002485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332002486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332002487 DNA binding residues [nucleotide binding] 83332002488 dimerization interface [polypeptide binding]; other site 83332002489 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332002490 cyclase homology domain; Region: CHD; cd07302 83332002491 nucleotidyl binding site; other site 83332002492 metal binding site [ion binding]; metal-binding site 83332002493 dimer interface [polypeptide binding]; other site 83332002494 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332002495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332002496 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332002497 Predicted ATPase [General function prediction only]; Region: COG3903 83332002498 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332002499 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332002500 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 83332002501 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 83332002502 dimer interface [polypeptide binding]; other site 83332002503 active site 83332002504 citrylCoA binding site [chemical binding]; other site 83332002505 NADH binding [chemical binding]; other site 83332002506 cationic pore residues; other site 83332002507 oxalacetate/citrate binding site [chemical binding]; other site 83332002508 coenzyme A binding site [chemical binding]; other site 83332002509 catalytic triad [active] 83332002510 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332002511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332002512 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 83332002513 BON domain; Region: BON; pfam04972 83332002514 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 83332002515 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 83332002516 ligand binding site [chemical binding]; other site 83332002517 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 83332002518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002520 dimerization interface [polypeptide binding]; other site 83332002521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002522 dimer interface [polypeptide binding]; other site 83332002523 phosphorylation site [posttranslational modification] 83332002524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002525 ATP binding site [chemical binding]; other site 83332002526 Mg2+ binding site [ion binding]; other site 83332002527 G-X-G motif; other site 83332002528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002530 active site 83332002531 phosphorylation site [posttranslational modification] 83332002532 intermolecular recognition site; other site 83332002533 dimerization interface [polypeptide binding]; other site 83332002534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002535 DNA binding site [nucleotide binding] 83332002536 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 83332002537 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 83332002538 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 83332002539 enoyl-CoA hydratase; Provisional; Region: PRK07854 83332002540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002541 substrate binding site [chemical binding]; other site 83332002542 oxyanion hole (OAH) forming residues; other site 83332002543 trimer interface [polypeptide binding]; other site 83332002544 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332002545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332002546 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 83332002547 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332002548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002549 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 83332002550 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332002551 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 83332002552 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332002553 hydrophobic ligand binding site; other site 83332002554 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332002555 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 83332002556 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 83332002557 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 83332002558 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332002559 active site 83332002560 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002561 PPE family; Region: PPE; pfam00823 83332002562 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332002563 PE family; Region: PE; pfam00934 83332002564 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 83332002565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 83332002566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002567 Coenzyme A binding pocket [chemical binding]; other site 83332002568 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332002569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332002570 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332002571 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332002572 catalytic residues [active] 83332002573 catalytic nucleophile [active] 83332002574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332002575 Probable transposase; Region: OrfB_IS605; pfam01385 83332002576 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 83332002577 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 83332002578 putative active site pocket [active] 83332002579 dimerization interface [polypeptide binding]; other site 83332002580 putative catalytic residue [active] 83332002581 Phage-related replication protein [General function prediction only]; Region: COG4195 83332002582 manganese transport protein MntH; Reviewed; Region: PRK00701 83332002583 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 83332002584 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 83332002585 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 83332002586 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 83332002587 short chain dehydrogenase; Provisional; Region: PRK07814 83332002588 classical (c) SDRs; Region: SDR_c; cd05233 83332002589 NAD(P) binding site [chemical binding]; other site 83332002590 active site 83332002591 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 83332002592 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 83332002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002594 dimer interface [polypeptide binding]; other site 83332002595 conserved gate region; other site 83332002596 putative PBP binding loops; other site 83332002597 ABC-ATPase subunit interface; other site 83332002598 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 83332002599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002600 dimer interface [polypeptide binding]; other site 83332002601 conserved gate region; other site 83332002602 putative PBP binding loops; other site 83332002603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 83332002604 ABC-ATPase subunit interface; other site 83332002605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332002606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332002607 active site 83332002608 ATP binding site [chemical binding]; other site 83332002609 substrate binding site [chemical binding]; other site 83332002610 activation loop (A-loop); other site 83332002611 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002612 SdiA-regulated; Region: SdiA-regulated; cl19046 83332002613 putative active site [active] 83332002614 NHL repeat; Region: NHL; pfam01436 83332002615 NHL repeat; Region: NHL; pfam01436 83332002616 NHL repeat; Region: NHL; pfam01436 83332002617 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 83332002618 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 83332002619 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 83332002620 Walker A/P-loop; other site 83332002621 ATP binding site [chemical binding]; other site 83332002622 Q-loop/lid; other site 83332002623 ABC transporter signature motif; other site 83332002624 Walker B; other site 83332002625 D-loop; other site 83332002626 H-loop/switch region; other site 83332002627 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 83332002628 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 83332002629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002630 dimer interface [polypeptide binding]; other site 83332002631 conserved gate region; other site 83332002632 putative PBP binding loops; other site 83332002633 ABC-ATPase subunit interface; other site 83332002634 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 83332002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332002636 dimer interface [polypeptide binding]; other site 83332002637 conserved gate region; other site 83332002638 putative PBP binding loops; other site 83332002639 ABC-ATPase subunit interface; other site 83332002640 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 83332002641 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 83332002642 putative DNA binding site [nucleotide binding]; other site 83332002643 putative homodimer interface [polypeptide binding]; other site 83332002644 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 83332002645 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 83332002646 nucleotide binding site [chemical binding]; other site 83332002647 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 83332002648 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 83332002649 active site 83332002650 DNA binding site [nucleotide binding] 83332002651 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 83332002652 DNA binding site [nucleotide binding] 83332002653 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 83332002654 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 83332002655 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332002656 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332002657 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332002658 anti sigma factor interaction site; other site 83332002659 regulatory phosphorylation site [posttranslational modification]; other site 83332002660 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332002661 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332002662 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332002663 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332002664 short chain dehydrogenase; Provisional; Region: PRK07024 83332002665 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 83332002666 putative NAD(P) binding site [chemical binding]; other site 83332002667 active site 83332002668 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 83332002669 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 83332002670 active site 83332002671 dimer interface [polypeptide binding]; other site 83332002672 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 83332002673 dimer interface [polypeptide binding]; other site 83332002674 active site 83332002675 Rv0947c, (MTCY10D7.27), len: 76 aa. Probable mycolyl transferase pseudogene, similar to part of P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) (fibronectin-binding protein C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 213, E(): 2e-08,(69.6% identity in 46 aa overlap). 83332002676 hypothetical protein; Provisional; Region: PRK07857 83332002677 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 83332002678 Part of AAA domain; Region: AAA_19; pfam13245 83332002679 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 83332002680 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332002681 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332002682 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 83332002683 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 83332002684 CoA-ligase; Region: Ligase_CoA; pfam00549 83332002685 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 83332002686 CoA binding domain; Region: CoA_binding; smart00881 83332002687 CoA-ligase; Region: Ligase_CoA; pfam00549 83332002688 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332002689 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 83332002690 active site 83332002691 substrate binding site [chemical binding]; other site 83332002692 cosubstrate binding site; other site 83332002693 catalytic site [active] 83332002694 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 83332002695 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 83332002696 purine monophosphate binding site [chemical binding]; other site 83332002697 dimer interface [polypeptide binding]; other site 83332002698 putative catalytic residues [active] 83332002699 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; pfam01808 83332002700 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 83332002701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 83332002702 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 83332002703 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 83332002704 metal ion-dependent adhesion site (MIDAS); other site 83332002705 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332002706 homotetrameric interface [polypeptide binding]; other site 83332002707 putative active site [active] 83332002708 metal binding site [ion binding]; metal-binding site 83332002709 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332002710 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332002711 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 83332002712 putative homodimer interface [polypeptide binding]; other site 83332002713 putative homotetramer interface [polypeptide binding]; other site 83332002714 allosteric switch controlling residues; other site 83332002715 putative metal binding site [ion binding]; other site 83332002716 putative homodimer-homodimer interface [polypeptide binding]; other site 83332002717 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332002718 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332002719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002720 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332002721 enoyl-CoA hydratase; Provisional; Region: PRK07827 83332002722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332002723 substrate binding site [chemical binding]; other site 83332002724 oxyanion hole (OAH) forming residues; other site 83332002725 trimer interface [polypeptide binding]; other site 83332002726 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002727 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332002728 active site 83332002729 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332002730 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332002731 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332002732 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332002733 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332002734 carboxyltransferase (CT) interaction site; other site 83332002735 biotinylation site [posttranslational modification]; other site 83332002736 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332002737 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332002738 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332002739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332002740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332002741 active site 83332002742 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 83332002743 PE family; Region: PE; pfam00934 83332002744 PE family; Region: PE; pfam00934 83332002745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002746 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002747 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002748 PE family; Region: PE; pfam00934 83332002749 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002750 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002751 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002752 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 83332002753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002755 active site 83332002756 phosphorylation site [posttranslational modification] 83332002757 intermolecular recognition site; other site 83332002758 dimerization interface [polypeptide binding]; other site 83332002759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002760 DNA binding site [nucleotide binding] 83332002761 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 83332002762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332002763 dimerization interface [polypeptide binding]; other site 83332002764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002765 dimer interface [polypeptide binding]; other site 83332002766 phosphorylation site [posttranslational modification] 83332002767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002768 ATP binding site [chemical binding]; other site 83332002769 Mg2+ binding site [ion binding]; other site 83332002770 G-X-G motif; other site 83332002771 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332002772 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 83332002773 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 83332002774 MPT binding site; other site 83332002775 trimer interface [polypeptide binding]; other site 83332002776 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 83332002777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332002778 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332002779 Walker A/P-loop; other site 83332002780 ATP binding site [chemical binding]; other site 83332002781 Q-loop/lid; other site 83332002782 ABC transporter signature motif; other site 83332002783 Walker B; other site 83332002784 D-loop; other site 83332002785 H-loop/switch region; other site 83332002786 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 83332002787 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332002788 FtsX-like permease family; Region: FtsX; pfam02687 83332002789 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332002790 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 83332002791 FtsX-like permease family; Region: FtsX; pfam02687 83332002792 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 83332002793 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332002794 substrate binding pocket [chemical binding]; other site 83332002795 chain length determination region; other site 83332002796 substrate-Mg2+ binding site; other site 83332002797 catalytic residues [active] 83332002798 aspartate-rich region 1; other site 83332002799 active site lid residues [active] 83332002800 aspartate-rich region 2; other site 83332002801 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 83332002802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 83332002803 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 83332002804 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 83332002805 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 83332002806 active site 83332002807 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 83332002808 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 83332002809 dimer interface [polypeptide binding]; other site 83332002810 putative functional site; other site 83332002811 putative MPT binding site; other site 83332002812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332002813 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 83332002814 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332002815 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332002816 ligand binding site [chemical binding]; other site 83332002817 flexible hinge region; other site 83332002818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332002819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332002820 Coenzyme A binding pocket [chemical binding]; other site 83332002821 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 83332002822 arginine deiminase; Provisional; Region: PRK01388 83332002823 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 83332002824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 83332002825 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 83332002826 putative SAM binding site [chemical binding]; other site 83332002827 putative homodimer interface [polypeptide binding]; other site 83332002828 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 83332002829 chorismate binding enzyme; Region: Chorismate_bind; cl10555 83332002830 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 83332002831 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 83332002832 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 83332002833 active site 83332002834 HIGH motif; other site 83332002835 KMSKS motif; other site 83332002836 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 83332002837 tRNA binding surface [nucleotide binding]; other site 83332002838 anticodon binding site; other site 83332002839 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 83332002840 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 83332002841 active site 83332002842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 83332002843 Domain of unknown function (DUF348); Region: DUF348; pfam03990 83332002844 Domain of unknown function (DUF348); Region: DUF348; pfam03990 83332002845 Domain of unknown function (DUF348); Region: DUF348; pfam03990 83332002846 G5 domain; Region: G5; pfam07501 83332002847 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332002848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332002849 S-adenosylmethionine binding site [chemical binding]; other site 83332002850 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 83332002851 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 83332002852 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 83332002853 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 83332002854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332002855 acyl-activating enzyme (AAE) consensus motif; other site 83332002856 AMP binding site [chemical binding]; other site 83332002857 active site 83332002858 CoA binding site [chemical binding]; other site 83332002859 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 83332002860 putative active site [active] 83332002861 catalytic residue [active] 83332002862 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 83332002863 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 83332002864 5S rRNA interface [nucleotide binding]; other site 83332002865 CTC domain interface [polypeptide binding]; other site 83332002866 L16 interface [polypeptide binding]; other site 83332002867 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 83332002868 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 83332002869 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 83332002870 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 83332002871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332002872 active site 83332002873 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 83332002874 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 83332002875 Substrate binding site; other site 83332002876 Mg++ binding site; other site 83332002877 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 83332002878 active site 83332002879 substrate binding site [chemical binding]; other site 83332002880 CoA binding site [chemical binding]; other site 83332002881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332002882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332002883 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 83332002884 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 83332002885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332002886 ATP binding site [chemical binding]; other site 83332002887 putative Mg++ binding site [ion binding]; other site 83332002888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332002889 nucleotide binding region [chemical binding]; other site 83332002890 ATP-binding site [chemical binding]; other site 83332002891 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 83332002892 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 83332002893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 83332002894 homodimer interface [polypeptide binding]; other site 83332002895 metal binding site [ion binding]; metal-binding site 83332002896 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 83332002897 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 83332002898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 83332002899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 83332002900 enolase; Provisional; Region: eno; PRK00077 83332002901 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 83332002902 dimer interface [polypeptide binding]; other site 83332002903 metal binding site [ion binding]; metal-binding site 83332002904 substrate binding pocket [chemical binding]; other site 83332002905 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 83332002906 Uncharacterized conserved protein [Function unknown]; Region: COG1507 83332002907 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 83332002908 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 83332002909 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 83332002910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002911 active site 83332002912 phosphorylation site [posttranslational modification] 83332002913 intermolecular recognition site; other site 83332002914 dimerization interface [polypeptide binding]; other site 83332002915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002916 DNA binding site [nucleotide binding] 83332002917 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 83332002918 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 83332002919 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 83332002920 Ligand Binding Site [chemical binding]; other site 83332002921 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 83332002922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002923 dimer interface [polypeptide binding]; other site 83332002924 phosphorylation site [posttranslational modification] 83332002925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002926 ATP binding site [chemical binding]; other site 83332002927 Mg2+ binding site [ion binding]; other site 83332002928 G-X-G motif; other site 83332002929 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 83332002930 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 83332002931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332002932 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 83332002933 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 83332002934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332002935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332002936 dimer interface [polypeptide binding]; other site 83332002937 phosphorylation site [posttranslational modification] 83332002938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332002939 ATP binding site [chemical binding]; other site 83332002940 Mg2+ binding site [ion binding]; other site 83332002941 G-X-G motif; other site 83332002942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332002943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332002944 active site 83332002945 phosphorylation site [posttranslational modification] 83332002946 intermolecular recognition site; other site 83332002947 dimerization interface [polypeptide binding]; other site 83332002948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332002949 DNA binding site [nucleotide binding] 83332002950 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332002951 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 83332002952 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332002953 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332002954 Transposase domain (DUF772); Region: DUF772; pfam05598 83332002955 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332002956 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332002957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332002958 PPE family; Region: PPE; pfam00823 83332002959 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332002960 PE family; Region: PE; pfam00934 83332002961 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332002962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 83332002963 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 83332002964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 83332002965 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 83332002966 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332002967 Predicted transcriptional regulator [Transcription]; Region: COG5340 83332002968 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332002969 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 83332002970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332002971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332002972 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332002973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 83332002974 putative DNA binding site [nucleotide binding]; other site 83332002975 putative Zn2+ binding site [ion binding]; other site 83332002976 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 83332002977 classical (c) SDRs; Region: SDR_c; cd05233 83332002978 NAD(P) binding site [chemical binding]; other site 83332002979 active site 83332002980 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 83332002981 Helix-turn-helix domain; Region: HTH_17; pfam12728 83332002982 mobile mystery protein B; Region: mob_myst_B; TIGR02613 83332002983 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 83332002984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332002985 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332002986 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 83332002987 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 83332002988 dimer interface [polypeptide binding]; other site 83332002989 acyl-activating enzyme (AAE) consensus motif; other site 83332002990 putative active site [active] 83332002991 AMP binding site [chemical binding]; other site 83332002992 putative CoA binding site [chemical binding]; other site 83332002993 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 83332002994 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 83332002995 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 83332002996 hydrophobic ligand binding site; other site 83332002997 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 83332002998 putative active site [active] 83332002999 putative dimer interface [polypeptide binding]; other site 83332003000 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332003001 Patatin-like phospholipase; Region: Patatin; pfam01734 83332003002 active site 83332003003 nucleophile elbow; other site 83332003004 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332003005 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 83332003006 active site 83332003007 nucleophile elbow; other site 83332003008 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 83332003009 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 83332003010 active site residue [active] 83332003011 PE family; Region: PE; pfam00934 83332003012 PE family; Region: PE; pfam00934 83332003013 Predicted membrane protein [Function unknown]; Region: COG4425 83332003014 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 83332003015 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 83332003016 enoyl-CoA hydratase; Provisional; Region: PRK05862 83332003017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003018 substrate binding site [chemical binding]; other site 83332003019 oxyanion hole (OAH) forming residues; other site 83332003020 trimer interface [polypeptide binding]; other site 83332003021 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 83332003022 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 83332003023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003024 substrate binding site [chemical binding]; other site 83332003025 oxyanion hole (OAH) forming residues; other site 83332003026 trimer interface [polypeptide binding]; other site 83332003027 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 83332003028 Predicted membrane protein [Function unknown]; Region: COG4760 83332003029 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332003030 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332003031 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 83332003032 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332003033 dimer interface [polypeptide binding]; other site 83332003034 active site 83332003035 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 83332003036 active site 83332003037 catalytic triad [active] 83332003038 oxyanion hole [active] 83332003039 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332003040 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332003041 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 83332003042 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332003043 dimer interface [polypeptide binding]; other site 83332003044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003045 catalytic residue [active] 83332003046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 83332003047 RDD family; Region: RDD; pfam06271 83332003048 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332003049 homodimer interface [polypeptide binding]; other site 83332003050 substrate-cofactor binding pocket; other site 83332003051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003052 catalytic residue [active] 83332003053 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 83332003054 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 83332003055 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 83332003056 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 83332003057 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 83332003058 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 83332003059 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 83332003060 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 83332003061 catalytic residues [active] 83332003062 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 83332003063 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 83332003064 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 83332003065 active site 83332003066 dimer interface [polypeptide binding]; other site 83332003067 PE family; Region: PE; pfam00934 83332003068 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 83332003069 dimer interface [polypeptide binding]; other site 83332003070 PE family; Region: PE; pfam00934 83332003071 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 83332003072 PE family; Region: PE; pfam00934 83332003073 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 83332003074 ATP-binding site [chemical binding]; other site 83332003075 CoA-binding site [chemical binding]; other site 83332003076 Mg2+-binding site [ion binding]; other site 83332003077 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 83332003078 dimer interface [polypeptide binding]; other site 83332003079 active site 83332003080 glycine-pyridoxal phosphate binding site [chemical binding]; other site 83332003081 folate binding site [chemical binding]; other site 83332003082 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 83332003083 dinuclear metal binding motif [ion binding]; other site 83332003084 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 83332003085 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 83332003086 putative active site [active] 83332003087 PhoH-like protein; Region: PhoH; pfam02562 83332003088 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 83332003089 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 83332003090 NodB motif; other site 83332003091 active site 83332003092 catalytic site [active] 83332003093 metal binding site [ion binding]; metal-binding site 83332003094 fumarate hydratase; Reviewed; Region: fumC; PRK00485 83332003095 Class II fumarases; Region: Fumarase_classII; cd01362 83332003096 active site 83332003097 tetramer interface [polypeptide binding]; other site 83332003098 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 83332003099 putative active site [active] 83332003100 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 83332003101 Domain of unknown function DUF20; Region: UPF0118; pfam01594 83332003102 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332003103 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 83332003104 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332003105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 83332003106 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332003107 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 83332003108 putative NAD(P) binding site [chemical binding]; other site 83332003109 active site 83332003110 putative substrate binding site [chemical binding]; other site 83332003111 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 83332003112 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 83332003113 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 83332003114 generic binding surface II; other site 83332003115 generic binding surface I; other site 83332003116 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332003117 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 83332003118 Fe-S cluster binding site [ion binding]; other site 83332003119 substrate binding site [chemical binding]; other site 83332003120 catalytic site [active] 83332003121 Yip1 domain; Region: Yip1; pfam04893 83332003122 GTP-binding protein YchF; Reviewed; Region: PRK09601 83332003123 YchF GTPase; Region: YchF; cd01900 83332003124 G1 box; other site 83332003125 GTP/Mg2+ binding site [chemical binding]; other site 83332003126 Switch I region; other site 83332003127 G2 box; other site 83332003128 Switch II region; other site 83332003129 G3 box; other site 83332003130 G4 box; other site 83332003131 G5 box; other site 83332003132 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 83332003133 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 83332003134 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332003135 putative active site [active] 83332003136 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332003137 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003138 cyclase homology domain; Region: CHD; cd07302 83332003139 nucleotidyl binding site; other site 83332003140 metal binding site [ion binding]; metal-binding site 83332003141 dimer interface [polypeptide binding]; other site 83332003142 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 83332003143 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 83332003144 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 83332003145 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 83332003146 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 83332003147 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 83332003148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332003149 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332003150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332003151 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332003152 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332003153 pyruvate phosphate dikinase; Provisional; Region: PRK05878 83332003154 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 83332003155 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 83332003156 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332003157 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332003158 active site 83332003159 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332003160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332003161 non-specific DNA binding site [nucleotide binding]; other site 83332003162 salt bridge; other site 83332003163 sequence-specific DNA binding site [nucleotide binding]; other site 83332003164 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 83332003165 Domain of unknown function (DUF955); Region: DUF955; pfam06114 83332003166 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 83332003167 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 83332003168 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 83332003169 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 83332003170 dimer interface [polypeptide binding]; other site 83332003171 active site 83332003172 citrylCoA binding site [chemical binding]; other site 83332003173 oxalacetate/citrate binding site [chemical binding]; other site 83332003174 coenzyme A binding site [chemical binding]; other site 83332003175 catalytic triad [active] 83332003176 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 83332003177 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 83332003178 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 83332003179 THF binding site; other site 83332003180 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 83332003181 substrate binding site [chemical binding]; other site 83332003182 THF binding site; other site 83332003183 zinc-binding site [ion binding]; other site 83332003184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003185 PPE family; Region: PPE; pfam00823 83332003186 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003187 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003188 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003189 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003190 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003191 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332003192 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 83332003193 active site 83332003194 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332003195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003196 substrate binding site [chemical binding]; other site 83332003197 oxyanion hole (OAH) forming residues; other site 83332003198 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 83332003199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332003200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332003201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332003202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 83332003203 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 83332003204 enoyl-CoA hydratase; Provisional; Region: PRK06688 83332003205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003206 substrate binding site [chemical binding]; other site 83332003207 trimer interface [polypeptide binding]; other site 83332003208 oxyanion hole (OAH) forming residues; other site 83332003209 enoyl-CoA hydratase; Provisional; Region: PRK06688 83332003210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332003211 substrate binding site [chemical binding]; other site 83332003212 oxyanion hole (OAH) forming residues; other site 83332003213 trimer interface [polypeptide binding]; other site 83332003214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332003215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 83332003216 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 83332003217 NAD binding site [chemical binding]; other site 83332003218 homodimer interface [polypeptide binding]; other site 83332003219 homotetramer interface [polypeptide binding]; other site 83332003220 active site 83332003221 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332003222 MMPL family; Region: MMPL; cl14618 83332003223 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332003224 MMPL family; Region: MMPL; cl14618 83332003225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003226 S-adenosylmethionine binding site [chemical binding]; other site 83332003227 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332003228 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332003229 active site 83332003230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 83332003231 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 83332003232 Rv1150, (MTCI65.17), len: 183 aa. Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis is element (308 aa), FASTA scores: opt: 959,E(): 0, (99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. 83332003233 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 83332003234 NAD+ binding site [chemical binding]; other site 83332003235 substrate binding site [chemical binding]; other site 83332003236 Zn binding site [ion binding]; other site 83332003237 Predicted transcriptional regulators [Transcription]; Region: COG1725 83332003238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 83332003239 DNA-binding site [nucleotide binding]; DNA binding site 83332003240 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332003241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 83332003242 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332003243 uncharacterized HhH-GPD family protein; Region: TIGR03252 83332003244 minor groove reading motif; other site 83332003245 helix-hairpin-helix signature motif; other site 83332003246 Transcription factor IIA, alpha/beta subunit; Region: TFIIA; pfam03153 83332003247 mannosyltransferase; Provisional; Region: pimE; PRK13375 83332003248 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 83332003249 aromatic arch; other site 83332003250 DCoH dimer interaction site [polypeptide binding]; other site 83332003251 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 83332003252 DCoH tetramer interaction site [polypeptide binding]; other site 83332003253 substrate binding site [chemical binding]; other site 83332003254 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 83332003255 active site 83332003256 8-oxo-dGMP binding site [chemical binding]; other site 83332003257 nudix motif; other site 83332003258 metal binding site [ion binding]; metal-binding site 83332003259 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 83332003260 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 83332003261 [4Fe-4S] binding site [ion binding]; other site 83332003262 molybdopterin cofactor binding site [chemical binding]; other site 83332003263 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 83332003264 molybdopterin cofactor binding site; other site 83332003265 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 83332003266 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 83332003267 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 83332003268 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 83332003269 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 83332003270 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 83332003271 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 83332003272 G1 box; other site 83332003273 putative GEF interaction site [polypeptide binding]; other site 83332003274 GTP/Mg2+ binding site [chemical binding]; other site 83332003275 Switch I region; other site 83332003276 G2 box; other site 83332003277 G3 box; other site 83332003278 Switch II region; other site 83332003279 G4 box; other site 83332003280 G5 box; other site 83332003281 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 83332003282 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 83332003283 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332003284 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 83332003285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332003286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003287 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003288 PPE family; Region: PPE; pfam00823 83332003289 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003290 PE family; Region: PE; pfam00934 83332003291 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 83332003292 PE family; Region: PE; pfam00934 83332003293 FO synthase; Reviewed; Region: fbiC; PRK09234 83332003294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332003295 FeS/SAM binding site; other site 83332003296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332003297 FeS/SAM binding site; other site 83332003298 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 83332003299 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 83332003300 active site 83332003301 FMN binding site [chemical binding]; other site 83332003302 2,4-decadienoyl-CoA binding site; other site 83332003303 catalytic residue [active] 83332003304 4Fe-4S cluster binding site [ion binding]; other site 83332003305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332003306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332003307 Predicted transcriptional regulators [Transcription]; Region: COG1695 83332003308 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 83332003309 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 83332003310 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 83332003311 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 83332003312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332003313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003314 homodimer interface [polypeptide binding]; other site 83332003315 catalytic residue [active] 83332003316 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332003317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 83332003318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332003319 ATP-binding site [chemical binding]; other site 83332003320 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332003321 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332003322 active site 83332003323 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332003324 Acyl transferase domain; Region: Acyl_transf_1; cl08282 83332003325 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332003326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003327 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332003328 Enoylreductase; Region: PKS_ER; smart00829 83332003329 NAD(P) binding site [chemical binding]; other site 83332003330 short chain dehydrogenase; Region: adh_short; pfam00106 83332003331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003332 NAD(P) binding site [chemical binding]; other site 83332003333 active site 83332003334 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332003335 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332003336 Condensation domain; Region: Condensation; cl19241 83332003337 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332003338 MMPL family; Region: MMPL; pfam03176 83332003339 MMPL family; Region: MMPL; pfam03176 83332003340 PE-PPE domain; Region: PE-PPE; pfam08237 83332003341 acyl-CoA synthetase; Validated; Region: PRK05850 83332003342 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332003343 acyl-activating enzyme (AAE) consensus motif; other site 83332003344 active site 83332003345 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332003346 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332003347 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 83332003348 Glutamate binding site [chemical binding]; other site 83332003349 NAD binding site [chemical binding]; other site 83332003350 catalytic residues [active] 83332003351 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 83332003352 Proline dehydrogenase; Region: Pro_dh; pfam01619 83332003353 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 83332003354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332003355 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 83332003356 DNA binding residues [nucleotide binding] 83332003357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332003358 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332003359 catalytic site [active] 83332003360 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332003361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332003362 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332003363 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332003364 PGAP1-like protein; Region: PGAP1; pfam07819 83332003365 acyl-CoA synthetase; Validated; Region: PRK07787 83332003366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332003367 acyl-activating enzyme (AAE) consensus motif; other site 83332003368 AMP binding site [chemical binding]; other site 83332003369 active site 83332003370 CoA binding site [chemical binding]; other site 83332003371 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332003372 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332003373 PE family; Region: PE; pfam00934 83332003374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003375 PPE family; Region: PPE; pfam00823 83332003376 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003377 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332003378 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332003379 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332003380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332003381 metabolite-proton symporter; Region: 2A0106; TIGR00883 83332003382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003383 putative substrate translocation pore; other site 83332003384 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 83332003385 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 83332003386 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 83332003387 putative trimer interface [polypeptide binding]; other site 83332003388 putative CoA binding site [chemical binding]; other site 83332003389 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 83332003390 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 83332003391 metal binding site [ion binding]; metal-binding site 83332003392 putative dimer interface [polypeptide binding]; other site 83332003393 AAA ATPase domain; Region: AAA_16; pfam13191 83332003394 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 83332003395 TIGR00730 family protein; Region: TIGR00730 83332003396 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 83332003397 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 83332003398 acyl-activating enzyme (AAE) consensus motif; other site 83332003399 putative AMP binding site [chemical binding]; other site 83332003400 putative active site [active] 83332003401 putative CoA binding site [chemical binding]; other site 83332003402 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 83332003403 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 83332003404 substrate binding pocket [chemical binding]; other site 83332003405 dimer interface [polypeptide binding]; other site 83332003406 inhibitor binding site; inhibition site 83332003407 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 83332003408 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332003409 DivIVA domain; Region: DivI1A_domain; TIGR03544 83332003410 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 83332003411 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 83332003412 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 83332003413 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332003414 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 83332003415 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 83332003416 ligand binding site; other site 83332003417 oligomer interface; other site 83332003418 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 83332003419 dimer interface [polypeptide binding]; other site 83332003420 N-terminal domain interface [polypeptide binding]; other site 83332003421 sulfate 1 binding site; other site 83332003422 PE family; Region: PE; pfam00934 83332003423 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 83332003424 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332003425 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 83332003426 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332003427 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 83332003428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332003429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332003430 Walker A/P-loop; other site 83332003431 ATP binding site [chemical binding]; other site 83332003432 Q-loop/lid; other site 83332003433 ABC transporter signature motif; other site 83332003434 Walker B; other site 83332003435 D-loop; other site 83332003436 H-loop/switch region; other site 83332003437 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 83332003438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332003440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003441 S-adenosylmethionine binding site [chemical binding]; other site 83332003442 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 83332003443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332003444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332003445 DNA binding residues [nucleotide binding] 83332003446 chaperone protein DnaJ; Provisional; Region: PRK10767 83332003447 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332003448 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 83332003449 protein binding site [polypeptide binding]; other site 83332003450 sec-independent translocase; Provisional; Region: PRK03100 83332003451 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 83332003452 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 83332003453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332003454 Predicted membrane protein [Function unknown]; Region: COG3428 83332003455 Bacterial PH domain; Region: bPH_2; pfam03703 83332003456 Bacterial PH domain; Region: bPH_2; cl01348 83332003457 Uncharacterized conserved protein [Function unknown]; Region: COG3402 83332003458 Domain of unknown function DUF59; Region: DUF59; cl00941 83332003459 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 83332003460 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 83332003461 Walker A motif; other site 83332003462 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 83332003463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 83332003464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 83332003465 catalytic residue [active] 83332003466 Predicted membrane protein [Function unknown]; Region: COG4420 83332003467 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 83332003468 MgtE intracellular N domain; Region: MgtE_N; smart00924 83332003469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 83332003470 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 83332003471 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 83332003472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332003473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332003474 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 83332003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003476 dimer interface [polypeptide binding]; other site 83332003477 conserved gate region; other site 83332003478 putative PBP binding loops; other site 83332003479 ABC-ATPase subunit interface; other site 83332003480 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332003481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003482 dimer interface [polypeptide binding]; other site 83332003483 conserved gate region; other site 83332003484 putative PBP binding loops; other site 83332003485 ABC-ATPase subunit interface; other site 83332003486 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 83332003487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332003488 Walker A/P-loop; other site 83332003489 ATP binding site [chemical binding]; other site 83332003490 Q-loop/lid; other site 83332003491 ABC transporter signature motif; other site 83332003492 Walker B; other site 83332003493 D-loop; other site 83332003494 H-loop/switch region; other site 83332003495 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 83332003496 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 83332003497 oligomer interface [polypeptide binding]; other site 83332003498 metal binding site [ion binding]; metal-binding site 83332003499 metal binding site [ion binding]; metal-binding site 83332003500 putative Cl binding site [ion binding]; other site 83332003501 basic sphincter; other site 83332003502 hydrophobic gate; other site 83332003503 periplasmic entrance; other site 83332003504 malate dehydrogenase; Provisional; Region: PRK05442 83332003505 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 83332003506 NAD(P) binding site [chemical binding]; other site 83332003507 dimer interface [polypeptide binding]; other site 83332003508 malate binding site [chemical binding]; other site 83332003509 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332003510 PE family; Region: PE; pfam00934 83332003511 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 83332003512 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332003513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003514 NAD(P) binding site [chemical binding]; other site 83332003515 active site 83332003516 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 83332003517 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332003518 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 83332003519 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332003520 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 83332003521 TPP-binding site [chemical binding]; other site 83332003522 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 83332003523 dimer interface [polypeptide binding]; other site 83332003524 PYR/PP interface [polypeptide binding]; other site 83332003525 TPP binding site [chemical binding]; other site 83332003526 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003528 putative substrate translocation pore; other site 83332003529 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 83332003530 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 83332003531 RNase_H superfamily; Region: RNase_H_2; pfam13482 83332003532 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 83332003533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332003534 ATP binding site [chemical binding]; other site 83332003535 putative Mg++ binding site [ion binding]; other site 83332003536 AAA domain; Region: AAA_12; pfam13087 83332003537 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332003538 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 83332003539 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 83332003540 ATP binding site [chemical binding]; other site 83332003541 Mg++ binding site [ion binding]; other site 83332003542 motif III; other site 83332003543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332003544 nucleotide binding region [chemical binding]; other site 83332003545 ATP-binding site [chemical binding]; other site 83332003546 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 83332003547 putative RNA binding site [nucleotide binding]; other site 83332003548 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332003549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332003550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003551 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332003552 FAD binding domain; Region: FAD_binding_4; pfam01565 83332003553 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 83332003554 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 83332003555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332003556 H+ Antiporter protein; Region: 2A0121; TIGR00900 83332003557 putative substrate translocation pore; other site 83332003558 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 83332003559 Fe-S cluster binding site [ion binding]; other site 83332003560 DNA binding site [nucleotide binding] 83332003561 active site 83332003562 hypothetical protein; Validated; Region: PRK05868 83332003563 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 83332003564 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332003565 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 83332003566 HIT family signature motif; other site 83332003567 catalytic residue [active] 83332003568 amidase; Provisional; Region: PRK12470 83332003569 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003570 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cd07556 83332003571 nucleotidyl binding site; other site 83332003572 metal binding site [ion binding]; metal-binding site 83332003573 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332003574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332003575 active site 83332003576 ATP binding site [chemical binding]; other site 83332003577 substrate binding site [chemical binding]; other site 83332003578 activation loop (A-loop); other site 83332003579 Rubella capsid protein; Region: Rubella_Capsid; pfam05750 83332003580 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332003581 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 83332003582 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 83332003583 DNA binding site [nucleotide binding] 83332003584 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332003585 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332003586 phosphopeptide binding site; other site 83332003587 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 83332003588 putative active site [active] 83332003589 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 83332003590 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332003591 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332003592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332003593 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 83332003594 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 83332003595 Walker A/P-loop; other site 83332003596 ATP binding site [chemical binding]; other site 83332003597 Q-loop/lid; other site 83332003598 ABC transporter signature motif; other site 83332003599 Walker B; other site 83332003600 D-loop; other site 83332003601 H-loop/switch region; other site 83332003602 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332003603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332003604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003605 Walker A/P-loop; other site 83332003606 ATP binding site [chemical binding]; other site 83332003607 Q-loop/lid; other site 83332003608 ABC transporter signature motif; other site 83332003609 Walker B; other site 83332003610 D-loop; other site 83332003611 H-loop/switch region; other site 83332003612 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332003613 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332003614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332003615 catalytic core [active] 83332003616 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 83332003617 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 83332003618 active site 83332003619 metal binding site [ion binding]; metal-binding site 83332003620 DNA binding site [nucleotide binding] 83332003621 AAA domain; Region: AAA_23; pfam13476 83332003622 Walker A/P-loop; other site 83332003623 ATP binding site [chemical binding]; other site 83332003624 AAA domain; Region: AAA_27; pfam13514 83332003625 choline dehydrogenase; Validated; Region: PRK02106 83332003626 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 83332003627 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332003628 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332003629 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 83332003630 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 83332003631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332003632 Walker A/P-loop; other site 83332003633 ATP binding site [chemical binding]; other site 83332003634 Q-loop/lid; other site 83332003635 ABC transporter signature motif; other site 83332003636 Walker B; other site 83332003637 D-loop; other site 83332003638 H-loop/switch region; other site 83332003639 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332003640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332003641 Walker A/P-loop; other site 83332003642 ATP binding site [chemical binding]; other site 83332003643 Q-loop/lid; other site 83332003644 ABC transporter signature motif; other site 83332003645 Walker B; other site 83332003646 D-loop; other site 83332003647 H-loop/switch region; other site 83332003648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332003649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 83332003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003651 dimer interface [polypeptide binding]; other site 83332003652 conserved gate region; other site 83332003653 putative PBP binding loops; other site 83332003654 ABC-ATPase subunit interface; other site 83332003655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 83332003656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332003657 dimer interface [polypeptide binding]; other site 83332003658 conserved gate region; other site 83332003659 putative PBP binding loops; other site 83332003660 ABC-ATPase subunit interface; other site 83332003661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 83332003662 active site clefts [active] 83332003663 zinc binding site [ion binding]; other site 83332003664 dimer interface [polypeptide binding]; other site 83332003665 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 83332003666 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 83332003667 Active Sites [active] 83332003668 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 83332003669 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 83332003670 CysD dimerization site [polypeptide binding]; other site 83332003671 G1 box; other site 83332003672 putative GEF interaction site [polypeptide binding]; other site 83332003673 GTP/Mg2+ binding site [chemical binding]; other site 83332003674 Switch I region; other site 83332003675 G2 box; other site 83332003676 G3 box; other site 83332003677 Switch II region; other site 83332003678 G4 box; other site 83332003679 G5 box; other site 83332003680 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 83332003681 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 83332003682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003683 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 83332003684 Walker A/P-loop; other site 83332003685 ligand-binding site [chemical binding]; other site 83332003686 ATP binding site [chemical binding]; other site 83332003687 Predicted transcriptional regulator [Transcription]; Region: COG1959 83332003688 Rrf2 family protein; Region: rrf2_super; TIGR00738 83332003689 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003690 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 83332003691 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003692 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 83332003693 Putative esterase; Region: Esterase; pfam00756 83332003694 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 83332003695 Predicted membrane protein [Function unknown]; Region: COG4325 83332003696 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 83332003697 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332003698 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 83332003699 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 83332003700 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 83332003701 active site 83332003702 HIGH motif; other site 83332003703 KMSK motif region; other site 83332003704 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 83332003705 tRNA binding surface [nucleotide binding]; other site 83332003706 anticodon binding site; other site 83332003707 diaminopimelate decarboxylase; Region: lysA; TIGR01048 83332003708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 83332003709 active site 83332003710 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332003711 substrate binding site [chemical binding]; other site 83332003712 catalytic residues [active] 83332003713 dimer interface [polypeptide binding]; other site 83332003714 homoserine dehydrogenase; Provisional; Region: PRK06349 83332003715 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 83332003716 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 83332003717 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 83332003718 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 83332003719 homodimer interface [polypeptide binding]; other site 83332003720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003721 catalytic residue [active] 83332003722 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 83332003723 transcription termination factor Rho; Provisional; Region: PRK12678 83332003724 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 83332003725 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 83332003726 RNA binding site [nucleotide binding]; other site 83332003727 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 83332003728 multimer interface [polypeptide binding]; other site 83332003729 Walker A motif; other site 83332003730 ATP binding site [chemical binding]; other site 83332003731 Walker B motif; other site 83332003732 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 83332003733 peptide chain release factor 1; Validated; Region: prfA; PRK00591 83332003734 This domain is found in peptide chain release factors; Region: PCRF; smart00937 83332003735 RF-1 domain; Region: RF-1; pfam00472 83332003736 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 83332003737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332003738 S-adenosylmethionine binding site [chemical binding]; other site 83332003739 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 83332003740 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 83332003741 Mg++ binding site [ion binding]; other site 83332003742 putative catalytic motif [active] 83332003743 substrate binding site [chemical binding]; other site 83332003744 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 83332003745 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 83332003746 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 83332003747 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 83332003748 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 83332003749 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 83332003750 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 83332003751 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 83332003752 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 83332003753 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 83332003754 beta subunit interaction interface [polypeptide binding]; other site 83332003755 Walker A motif; other site 83332003756 ATP binding site [chemical binding]; other site 83332003757 Walker B motif; other site 83332003758 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 83332003759 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 83332003760 core domain interface [polypeptide binding]; other site 83332003761 delta subunit interface [polypeptide binding]; other site 83332003762 epsilon subunit interface [polypeptide binding]; other site 83332003763 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 83332003764 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 83332003765 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 83332003766 alpha subunit interaction interface [polypeptide binding]; other site 83332003767 Walker A motif; other site 83332003768 ATP binding site [chemical binding]; other site 83332003769 Walker B motif; other site 83332003770 inhibitor binding site; inhibition site 83332003771 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 83332003772 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 83332003773 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 83332003774 gamma subunit interface [polypeptide binding]; other site 83332003775 epsilon subunit interface [polypeptide binding]; other site 83332003776 LBP interface [polypeptide binding]; other site 83332003777 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 83332003778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332003779 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 83332003780 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 83332003781 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332003782 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 83332003783 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 83332003784 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 83332003785 hinge; other site 83332003786 active site 83332003787 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 83332003788 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 83332003789 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 83332003790 DNA binding site [nucleotide binding] 83332003791 active site 83332003792 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 83332003793 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 83332003794 AlkA N-terminal domain; Region: AlkA_N; pfam06029 83332003795 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 83332003796 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332003797 minor groove reading motif; other site 83332003798 helix-hairpin-helix signature motif; other site 83332003799 substrate binding pocket [chemical binding]; other site 83332003800 active site 83332003801 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 83332003802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332003803 dimerization interface [polypeptide binding]; other site 83332003804 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003805 cyclase homology domain; Region: CHD; cd07302 83332003806 nucleotidyl binding site; other site 83332003807 metal binding site [ion binding]; metal-binding site 83332003808 dimer interface [polypeptide binding]; other site 83332003809 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 83332003810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332003811 dimerization interface [polypeptide binding]; other site 83332003812 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003813 cyclase homology domain; Region: CHD; cd07302 83332003814 nucleotidyl binding site; other site 83332003815 metal binding site [ion binding]; metal-binding site 83332003816 dimer interface [polypeptide binding]; other site 83332003817 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 83332003818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332003819 dimerization interface [polypeptide binding]; other site 83332003820 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003821 cyclase homology domain; Region: CHD; cd07302 83332003822 nucleotidyl binding site; other site 83332003823 metal binding site [ion binding]; metal-binding site 83332003824 dimer interface [polypeptide binding]; other site 83332003825 hypothetical protein; Provisional; Region: PRK03298 83332003826 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 83332003827 dimer interface [polypeptide binding]; other site 83332003828 substrate binding site [chemical binding]; other site 83332003829 metal binding site [ion binding]; metal-binding site 83332003830 putative acyltransferase; Provisional; Region: PRK05790 83332003831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332003832 dimer interface [polypeptide binding]; other site 83332003833 active site 83332003834 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 83332003835 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 83332003836 Tetratricopeptide repeat; Region: TPR_20; pfam14561 83332003837 PE family; Region: PE; pfam00934 83332003838 glycogen branching enzyme; Provisional; Region: PRK05402 83332003839 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 83332003840 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 83332003841 active site 83332003842 catalytic site [active] 83332003843 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 83332003844 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 83332003845 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 83332003846 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 83332003847 active site 83332003848 homodimer interface [polypeptide binding]; other site 83332003849 catalytic site [active] 83332003850 acceptor binding site [chemical binding]; other site 83332003851 Glucan phosphorylase [Carbohydrate transport and metabolism]; Region: GlgP; COG0058 83332003852 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 83332003853 putative homodimer interface [polypeptide binding]; other site 83332003854 putative active site pocket [active] 83332003855 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 83332003856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 83332003857 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 83332003858 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 83332003859 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 83332003860 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 83332003861 active site 83332003862 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 83332003863 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 83332003864 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 83332003865 putative active site pocket [active] 83332003866 cleavage site 83332003867 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 83332003868 MPN+ (JAMM) motif; other site 83332003869 Zinc-binding site [ion binding]; other site 83332003870 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332003871 MoaE interaction surface [polypeptide binding]; other site 83332003872 MoeB interaction surface [polypeptide binding]; other site 83332003873 thiocarboxylated glycine; other site 83332003874 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332003875 dimer interface [polypeptide binding]; other site 83332003876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332003877 catalytic residue [active] 83332003878 Rhomboid family; Region: Rhomboid; pfam01694 83332003879 glutamate racemase; Provisional; Region: PRK00865 83332003880 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 83332003881 ribonuclease PH; Reviewed; Region: rph; PRK00173 83332003882 Ribonuclease PH; Region: RNase_PH_bact; cd11362 83332003883 hexamer interface [polypeptide binding]; other site 83332003884 active site 83332003885 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 83332003886 active site 83332003887 dimerization interface [polypeptide binding]; other site 83332003888 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 83332003889 Glucitol operon activator [Transcription]; Region: GutM; COG4578 83332003890 acyl carrier protein; Validated; Region: PRK05883 83332003891 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 83332003892 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332003893 acyl-activating enzyme (AAE) consensus motif; other site 83332003894 active site 83332003895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332003896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332003897 active site 83332003898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 83332003899 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 83332003900 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 83332003901 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 83332003902 FAD binding pocket [chemical binding]; other site 83332003903 FAD binding motif [chemical binding]; other site 83332003904 phosphate binding motif [ion binding]; other site 83332003905 NAD binding pocket [chemical binding]; other site 83332003906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332003907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003908 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 83332003909 Walker A/P-loop; other site 83332003910 ATP binding site [chemical binding]; other site 83332003911 Q-loop/lid; other site 83332003912 ABC transporter signature motif; other site 83332003913 Walker B; other site 83332003914 D-loop; other site 83332003915 H-loop/switch region; other site 83332003916 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 83332003917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332003918 Walker A/P-loop; other site 83332003919 ATP binding site [chemical binding]; other site 83332003920 Q-loop/lid; other site 83332003921 ABC transporter signature motif; other site 83332003922 Walker B; other site 83332003923 D-loop; other site 83332003924 H-loop/switch region; other site 83332003925 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 83332003926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332003927 NAD(P) binding site [chemical binding]; other site 83332003928 active site 83332003929 tetracycline repressor protein TetR; Provisional; Region: PRK13756 83332003930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332003931 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 83332003932 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 83332003933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 83332003934 metal binding site [ion binding]; metal-binding site 83332003935 active site 83332003936 I-site; other site 83332003937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 83332003938 hypothetical protein; Provisional; Region: PRK07877 83332003939 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 83332003940 ATP binding site [chemical binding]; other site 83332003941 substrate interface [chemical binding]; other site 83332003942 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 83332003943 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332003944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 83332003945 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003946 cyclase homology domain; Region: CHD; cd07302 83332003947 nucleotidyl binding site; other site 83332003948 metal binding site [ion binding]; metal-binding site 83332003949 dimer interface [polypeptide binding]; other site 83332003950 Predicted ATPase [General function prediction only]; Region: COG3903 83332003951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332003952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332003953 DNA binding residues [nucleotide binding] 83332003954 dimerization interface [polypeptide binding]; other site 83332003955 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332003956 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 83332003957 metal binding site [ion binding]; metal-binding site 83332003958 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332003959 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332003960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332003961 PPE family; Region: PPE; pfam00823 83332003962 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332003963 PAS domain S-box; Region: sensory_box; TIGR00229 83332003964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 83332003965 putative active site [active] 83332003966 heme pocket [chemical binding]; other site 83332003967 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 83332003968 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 83332003969 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 83332003970 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332003971 anti sigma factor interaction site; other site 83332003972 regulatory phosphorylation site [posttranslational modification]; other site 83332003973 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332003974 anti sigma factor interaction site; other site 83332003975 regulatory phosphorylation site [posttranslational modification]; other site 83332003976 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 83332003977 synthetase active site [active] 83332003978 NTP binding site [chemical binding]; other site 83332003979 metal binding site [ion binding]; metal-binding site 83332003980 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332003981 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332003982 putative transposase OrfB; Reviewed; Region: PHA02517 83332003983 HTH-like domain; Region: HTH_21; pfam13276 83332003984 Integrase core domain; Region: rve; pfam00665 83332003985 Integrase core domain; Region: rve_3; pfam13683 83332003986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332003987 Transposase; Region: HTH_Tnp_1; cl17663 83332003988 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 83332003989 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 83332003990 putative di-iron ligands [ion binding]; other site 83332003991 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332003992 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332003993 malonyl-CoA binding site [chemical binding]; other site 83332003994 dimer interface [polypeptide binding]; other site 83332003995 active site 83332003996 product binding site; other site 83332003997 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 83332003998 uncharacterized domain; Region: TIGR00702 83332003999 Uncharacterized conserved protein [Function unknown]; Region: COG3482 83332004000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004001 S-adenosylmethionine binding site [chemical binding]; other site 83332004002 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332004004 active site 83332004005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332004006 active site 83332004007 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 83332004008 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 83332004009 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 83332004010 dihydroorotase; Validated; Region: pyrC; PRK09357 83332004011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332004012 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 83332004013 active site 83332004014 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 83332004015 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 83332004016 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 83332004017 catalytic site [active] 83332004018 subunit interface [polypeptide binding]; other site 83332004019 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 83332004020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332004021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332004022 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 83332004023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332004024 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332004025 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 83332004026 IMP binding site; other site 83332004027 dimer interface [polypeptide binding]; other site 83332004028 interdomain contacts; other site 83332004029 partial ornithine binding site; other site 83332004030 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 83332004031 active site 83332004032 dimer interface [polypeptide binding]; other site 83332004033 PE family; Region: PE; pfam00934 83332004034 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332004035 PPE family; Region: PPE; pfam00823 83332004036 Guanylate kinase; Region: Guanylate_kin; pfam00625 83332004037 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 83332004038 catalytic site [active] 83332004039 G-X2-G-X-G-K; other site 83332004040 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 83332004041 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 83332004042 Flavoprotein; Region: Flavoprotein; cl19190 83332004043 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 83332004044 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 83332004045 S-adenosylmethionine synthetase; Validated; Region: PRK05250 83332004046 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 83332004047 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 83332004048 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332004049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332004050 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332004051 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332004052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332004053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332004054 PE family; Region: PE; pfam00934 83332004055 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332004056 oligomeric interface; other site 83332004057 putative active site [active] 83332004058 homodimer interface [polypeptide binding]; other site 83332004059 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332004060 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332004061 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332004062 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332004063 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332004064 Predicted membrane protein [Function unknown]; Region: COG3714 83332004065 primosome assembly protein PriA; Provisional; Region: PRK14873 83332004066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332004067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004068 S-adenosylmethionine binding site [chemical binding]; other site 83332004069 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332004070 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004072 S-adenosylmethionine binding site [chemical binding]; other site 83332004073 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 83332004074 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 83332004075 putative active site [active] 83332004076 substrate binding site [chemical binding]; other site 83332004077 putative cosubstrate binding site; other site 83332004078 catalytic site [active] 83332004079 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 83332004080 substrate binding site [chemical binding]; other site 83332004081 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 83332004082 putative RNA binding site [nucleotide binding]; other site 83332004083 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 83332004084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004085 S-adenosylmethionine binding site [chemical binding]; other site 83332004086 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 83332004087 substrate binding site [chemical binding]; other site 83332004088 hexamer interface [polypeptide binding]; other site 83332004089 metal binding site [ion binding]; metal-binding site 83332004090 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 83332004091 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 83332004092 catalytic motif [active] 83332004093 Zn binding site [ion binding]; other site 83332004094 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 83332004095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332004096 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 83332004097 putative substrate translocation pore; other site 83332004098 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332004099 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 83332004100 Lumazine binding domain; Region: Lum_binding; pfam00677 83332004101 Lumazine binding domain; Region: Lum_binding; pfam00677 83332004102 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332004103 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 83332004104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 83332004105 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332004106 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 83332004107 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 83332004108 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 83332004109 dimerization interface [polypeptide binding]; other site 83332004110 active site 83332004111 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 83332004112 homopentamer interface [polypeptide binding]; other site 83332004113 active site 83332004114 Bacterial PH domain; Region: bPH_6; pfam10756 83332004115 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332004116 Ricin-type beta-trefoil; Region: RICIN; smart00458 83332004117 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 83332004118 putative sugar binding sites [chemical binding]; other site 83332004119 Q-X-W motif; other site 83332004120 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 83332004121 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 83332004122 GIY-YIG motif/motif A; other site 83332004123 active site 83332004124 catalytic site [active] 83332004125 putative DNA binding site [nucleotide binding]; other site 83332004126 metal binding site [ion binding]; metal-binding site 83332004127 UvrB/uvrC motif; Region: UVR; pfam02151 83332004128 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 83332004129 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 83332004130 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 83332004131 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 83332004132 phosphate binding site [ion binding]; other site 83332004133 putative substrate binding pocket [chemical binding]; other site 83332004134 dimer interface [polypeptide binding]; other site 83332004135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 83332004136 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 83332004137 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 83332004138 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 83332004139 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332004140 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332004141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332004142 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332004143 acyl-CoA synthetase; Provisional; Region: PRK13382 83332004144 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 83332004145 acyl-activating enzyme (AAE) consensus motif; other site 83332004146 putative AMP binding site [chemical binding]; other site 83332004147 putative active site [active] 83332004148 putative CoA binding site [chemical binding]; other site 83332004149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332004150 putative acyl-acceptor binding pocket; other site 83332004151 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332004152 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332004153 PE family; Region: PE; pfam00934 83332004154 PE-PPE domain; Region: PE-PPE; pfam08237 83332004155 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 83332004156 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332004157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332004158 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 83332004159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332004160 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332004161 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 83332004162 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 83332004163 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 83332004164 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 83332004165 substrate binding site [chemical binding]; other site 83332004166 hinge regions; other site 83332004167 ADP binding site [chemical binding]; other site 83332004168 catalytic site [active] 83332004169 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 83332004170 substrate binding site [chemical binding]; other site 83332004171 dimer interface [polypeptide binding]; other site 83332004172 catalytic triad [active] 83332004173 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332004174 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 83332004175 PE family; Region: PE; pfam00934 83332004176 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 83332004177 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 83332004178 molybdopterin cofactor binding site [chemical binding]; other site 83332004179 substrate binding site [chemical binding]; other site 83332004180 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 83332004181 molybdopterin cofactor binding site; other site 83332004182 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 83332004183 hydrophobic ligand binding site; other site 83332004184 Proteins of 100 residues with WXG; Region: WXG100; cl02005 83332004185 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 83332004186 putative active site [active] 83332004187 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 83332004188 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 83332004189 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 83332004190 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 83332004191 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 83332004192 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 83332004193 putative active site [active] 83332004194 catalytic residue [active] 83332004195 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 83332004196 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 83332004197 TPP-binding site [chemical binding]; other site 83332004198 dimer interface [polypeptide binding]; other site 83332004199 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332004200 PYR/PP interface [polypeptide binding]; other site 83332004201 dimer interface [polypeptide binding]; other site 83332004202 TPP binding site [chemical binding]; other site 83332004203 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332004204 PE family; Region: PE; pfam00934 83332004205 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 83332004206 putative active site [active] 83332004207 PE family; Region: PE; pfam00934 83332004208 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332004209 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332004210 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 83332004211 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 83332004212 NADP binding site [chemical binding]; other site 83332004213 dimer interface [polypeptide binding]; other site 83332004214 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 83332004215 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332004216 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332004217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332004218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332004219 Walker A/P-loop; other site 83332004220 ATP binding site [chemical binding]; other site 83332004221 Q-loop/lid; other site 83332004222 ABC transporter signature motif; other site 83332004223 Walker B; other site 83332004224 D-loop; other site 83332004225 H-loop/switch region; other site 83332004226 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 83332004227 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332004228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332004229 putative DNA binding site [nucleotide binding]; other site 83332004230 putative Zn2+ binding site [ion binding]; other site 83332004231 Transcriptional regulator PadR-like family; Region: PadR; cl17335 83332004232 Uncharacterized protein family (UPF0051); Region: UPF0051; cl19515 83332004233 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332004234 protein-splicing catalytic site; other site 83332004235 thioester formation/cholesterol transfer; other site 83332004236 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 83332004237 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 83332004238 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332004239 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 83332004240 protein-splicing catalytic site; other site 83332004241 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 83332004242 FeS assembly protein SufD; Region: sufD; TIGR01981 83332004243 FeS assembly ATPase SufC; Region: sufC; TIGR01978 83332004244 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 83332004245 Walker A/P-loop; other site 83332004246 ATP binding site [chemical binding]; other site 83332004247 Q-loop/lid; other site 83332004248 ABC transporter signature motif; other site 83332004249 Walker B; other site 83332004250 D-loop; other site 83332004251 H-loop/switch region; other site 83332004252 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 83332004253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332004254 catalytic residue [active] 83332004255 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 83332004256 trimerization site [polypeptide binding]; other site 83332004257 active site 83332004258 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 83332004259 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 83332004260 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 83332004261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332004262 active site 83332004263 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 83332004264 PE family; Region: PE; pfam00934 83332004265 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 83332004266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332004267 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332004268 catalytic residues [active] 83332004269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332004270 catalytic residues [active] 83332004271 enoyl-CoA hydratase; Provisional; Region: PRK05864 83332004272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332004273 substrate binding site [chemical binding]; other site 83332004274 oxyanion hole (OAH) forming residues; other site 83332004275 trimer interface [polypeptide binding]; other site 83332004276 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 83332004277 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004278 ABC transporter; Region: ABC_tran_2; pfam12848 83332004279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004282 aconitate hydratase; Validated; Region: PRK09277 83332004283 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 83332004284 substrate binding site [chemical binding]; other site 83332004285 ligand binding site [chemical binding]; other site 83332004286 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 83332004287 substrate binding site [chemical binding]; other site 83332004288 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 83332004289 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004290 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004291 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004292 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004293 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332004294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332004295 Walker A motif; other site 83332004296 ATP binding site [chemical binding]; other site 83332004297 Walker B motif; other site 83332004298 arginine finger; other site 83332004299 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332004300 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332004301 hypothetical protein; Provisional; Region: PRK13685 83332004302 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 83332004303 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 83332004304 metal ion-dependent adhesion site (MIDAS); other site 83332004305 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 83332004306 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 83332004307 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 83332004308 NAD(P) binding site [chemical binding]; other site 83332004309 homotetramer interface [polypeptide binding]; other site 83332004310 homodimer interface [polypeptide binding]; other site 83332004311 active site 83332004312 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 83332004313 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 83332004314 NAD binding site [chemical binding]; other site 83332004315 homotetramer interface [polypeptide binding]; other site 83332004316 homodimer interface [polypeptide binding]; other site 83332004317 substrate binding site [chemical binding]; other site 83332004318 active site 83332004319 ferrochelatase; Reviewed; Region: hemH; PRK00035 83332004320 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 83332004321 C-terminal domain interface [polypeptide binding]; other site 83332004322 active site 83332004323 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 83332004324 active site 83332004325 N-terminal domain interface [polypeptide binding]; other site 83332004326 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 83332004327 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 83332004328 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 83332004329 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 83332004330 DoxX-like family; Region: DoxX_2; pfam13564 83332004331 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 83332004332 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332004333 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 83332004334 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 83332004335 heterodimer interface [polypeptide binding]; other site 83332004336 substrate interaction site [chemical binding]; other site 83332004337 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 83332004338 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 83332004339 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 83332004340 active site 83332004341 substrate binding site [chemical binding]; other site 83332004342 coenzyme B12 binding site [chemical binding]; other site 83332004343 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 83332004344 B12 binding site [chemical binding]; other site 83332004345 cobalt ligand [ion binding]; other site 83332004346 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332004347 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 83332004348 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 83332004349 Walker A; other site 83332004350 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332004351 G4 box; other site 83332004352 G5 box; other site 83332004353 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332004354 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004356 S-adenosylmethionine binding site [chemical binding]; other site 83332004357 Uncharacterized conserved protein [Function unknown]; Region: COG3360 83332004358 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 83332004359 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 83332004360 Ligand binding site; other site 83332004361 Putative Catalytic site; other site 83332004362 DXD motif; other site 83332004363 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 83332004364 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 83332004365 active site 83332004366 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332004367 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332004368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332004369 catalytic residue [active] 83332004370 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 83332004371 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 83332004372 putative trimer interface [polypeptide binding]; other site 83332004373 putative CoA binding site [chemical binding]; other site 83332004374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004375 S-adenosylmethionine binding site [chemical binding]; other site 83332004376 WbqC-like protein family; Region: WbqC; pfam08889 83332004377 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 83332004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004380 S-adenosylmethionine binding site [chemical binding]; other site 83332004381 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 83332004382 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 83332004383 NADP-binding site; other site 83332004384 homotetramer interface [polypeptide binding]; other site 83332004385 substrate binding site [chemical binding]; other site 83332004386 homodimer interface [polypeptide binding]; other site 83332004387 active site 83332004388 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 83332004389 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 83332004390 NADP binding site [chemical binding]; other site 83332004391 active site 83332004392 putative substrate binding site [chemical binding]; other site 83332004393 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332004394 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 83332004395 metal-binding site 83332004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004397 S-adenosylmethionine binding site [chemical binding]; other site 83332004398 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332004400 active site 83332004401 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332004402 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004403 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 83332004404 active site 83332004405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332004406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332004407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332004408 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332004409 active site 83332004410 acyl-CoA synthetase; Validated; Region: PRK05850 83332004411 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332004412 acyl-activating enzyme (AAE) consensus motif; other site 83332004413 active site 83332004414 Transport protein; Region: actII; TIGR00833 83332004415 MMPL family; Region: MMPL; pfam03176 83332004416 MMPL family; Region: MMPL; pfam03176 83332004417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004418 S-adenosylmethionine binding site [chemical binding]; other site 83332004419 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332004420 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332004421 homodimer interface [polypeptide binding]; other site 83332004422 active site 83332004423 TDP-binding site; other site 83332004424 acceptor substrate-binding pocket; other site 83332004425 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332004426 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 83332004427 Probable Catalytic site; other site 83332004428 metal-binding site 83332004429 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332004430 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332004431 homodimer interface [polypeptide binding]; other site 83332004432 active site 83332004433 TDP-binding site; other site 83332004434 acceptor substrate-binding pocket; other site 83332004435 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004436 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004437 active site 83332004438 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332004439 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332004440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004441 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004442 Enoylreductase; Region: PKS_ER; smart00829 83332004443 NAD(P) binding site [chemical binding]; other site 83332004444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004445 short chain dehydrogenase; Region: adh_short; pfam00106 83332004446 NAD(P) binding site [chemical binding]; other site 83332004447 active site 83332004448 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004449 acyl-CoA synthetase; Validated; Region: PRK05850 83332004450 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332004451 acyl-activating enzyme (AAE) consensus motif; other site 83332004452 active site 83332004453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332004454 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 83332004455 NAD(P) binding site [chemical binding]; other site 83332004456 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332004457 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 83332004458 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332004459 CoenzymeA binding site [chemical binding]; other site 83332004460 subunit interaction site [polypeptide binding]; other site 83332004461 PHB binding site; other site 83332004462 Nitronate monooxygenase; Region: NMO; pfam03060 83332004463 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332004464 FMN binding site [chemical binding]; other site 83332004465 substrate binding site [chemical binding]; other site 83332004466 putative catalytic residue [active] 83332004467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004469 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 83332004470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 83332004471 active site 83332004472 HIGH motif; other site 83332004473 nucleotide binding site [chemical binding]; other site 83332004474 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 83332004475 active site 83332004476 KMSKS motif; other site 83332004477 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 83332004478 tRNA binding surface [nucleotide binding]; other site 83332004479 anticodon binding site; other site 83332004480 DNA polymerase IV; Provisional; Region: PRK03348 83332004481 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 83332004482 active site 83332004483 DNA binding site [nucleotide binding] 83332004484 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 83332004485 active site 83332004486 homodimer interface [polypeptide binding]; other site 83332004487 homotetramer interface [polypeptide binding]; other site 83332004488 lipoprotein signal peptidase; Provisional; Region: PRK14764 83332004489 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 83332004490 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 83332004491 active site 83332004492 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 83332004493 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 83332004494 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 83332004495 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 83332004496 apolar tunnel; other site 83332004497 heme binding site [chemical binding]; other site 83332004498 dimerization interface [polypeptide binding]; other site 83332004499 short chain dehydrogenase; Provisional; Region: PRK05866 83332004500 classical (c) SDRs; Region: SDR_c; cd05233 83332004501 NAD(P) binding site [chemical binding]; other site 83332004502 active site 83332004503 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332004504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004505 NAD(P) binding site [chemical binding]; other site 83332004506 active site 83332004507 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332004508 hydrophobic ligand binding site; other site 83332004509 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 83332004510 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 83332004511 active site 83332004512 PHP Thumb interface [polypeptide binding]; other site 83332004513 metal binding site [ion binding]; metal-binding site 83332004514 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 83332004515 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 83332004516 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 83332004517 generic binding surface II; other site 83332004518 generic binding surface I; other site 83332004519 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332004520 PPE family; Region: PPE; pfam00823 83332004521 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004522 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004523 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004524 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004525 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004526 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332004527 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332004528 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332004529 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 83332004530 acyl-activating enzyme (AAE) consensus motif; other site 83332004531 putative AMP binding site [chemical binding]; other site 83332004532 putative active site [active] 83332004533 putative CoA binding site [chemical binding]; other site 83332004534 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 83332004535 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 83332004536 putative acyl-acceptor binding pocket; other site 83332004537 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 83332004538 L-aspartate oxidase; Provisional; Region: PRK06175 83332004539 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332004540 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 83332004541 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 83332004542 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 83332004543 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 83332004544 D-subunit interface [polypeptide binding]; other site 83332004545 Iron-sulfur protein interface; other site 83332004546 proximal quinone binding site [chemical binding]; other site 83332004547 distal quinone binding site [chemical binding]; other site 83332004548 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 83332004549 Iron-sulfur protein interface; other site 83332004550 proximal quinone binding site [chemical binding]; other site 83332004551 C-subunit interface; other site 83332004552 distal quinone binding site; other site 83332004553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004555 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332004556 MMPL family; Region: MMPL; pfam03176 83332004557 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332004558 threonine dehydratase; Validated; Region: PRK08639 83332004559 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 83332004560 tetramer interface [polypeptide binding]; other site 83332004561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004562 catalytic residue [active] 83332004563 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 83332004564 putative Ile/Val binding site [chemical binding]; other site 83332004565 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332004566 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332004567 putative active site [active] 83332004568 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 83332004569 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 83332004570 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 83332004571 catalytic site [active] 83332004572 active site 83332004573 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 83332004574 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 83332004575 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 83332004576 active site 83332004577 catalytic site [active] 83332004578 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 83332004579 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 83332004580 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 83332004581 active site 83332004582 catalytic site [active] 83332004583 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 83332004584 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332004585 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332004586 hypothetical protein; Provisional; Region: PHA03160 83332004587 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332004588 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332004589 inhibitor-cofactor binding pocket; inhibition site 83332004590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004591 catalytic residue [active] 83332004592 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 83332004593 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 83332004594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332004595 catalytic residue [active] 83332004596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332004597 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 83332004598 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 83332004599 Phage head maturation protease [General function prediction only]; Region: COG3740 83332004600 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 83332004601 Phage associated DNA primase [General function prediction only]; Region: COG3378 83332004602 D5 N terminal like; Region: D5_N; smart00885 83332004603 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 83332004604 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 83332004605 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 83332004606 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 83332004607 catalytic residues [active] 83332004608 catalytic nucleophile [active] 83332004609 Recombinase; Region: Recombinase; pfam07508 83332004610 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 83332004611 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004612 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332004613 active site 83332004614 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332004615 biotin synthase; Validated; Region: PRK06256 83332004616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332004617 FeS/SAM binding site; other site 83332004618 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 83332004619 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 83332004620 Secretory lipase; Region: LIP; pfam03583 83332004621 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 83332004622 nudix motif; other site 83332004623 quinolinate synthetase; Provisional; Region: PRK09375 83332004624 L-aspartate oxidase; Provisional; Region: PRK07804 83332004625 L-aspartate oxidase; Provisional; Region: PRK06175 83332004626 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332004627 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 83332004628 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 83332004629 dimerization interface [polypeptide binding]; other site 83332004630 active site 83332004631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332004632 S-adenosylmethionine binding site [chemical binding]; other site 83332004633 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 83332004634 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 83332004635 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 83332004636 NAD binding site [chemical binding]; other site 83332004637 dimerization interface [polypeptide binding]; other site 83332004638 product binding site; other site 83332004639 substrate binding site [chemical binding]; other site 83332004640 zinc binding site [ion binding]; other site 83332004641 catalytic residues [active] 83332004642 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 83332004643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332004644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004645 homodimer interface [polypeptide binding]; other site 83332004646 catalytic residue [active] 83332004647 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 83332004648 putative active site pocket [active] 83332004649 4-fold oligomerization interface [polypeptide binding]; other site 83332004650 metal binding residues [ion binding]; metal-binding site 83332004651 3-fold/trimer interface [polypeptide binding]; other site 83332004652 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 83332004653 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 83332004654 putative active site [active] 83332004655 oxyanion strand; other site 83332004656 catalytic triad [active] 83332004657 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 83332004658 catalytic residues [active] 83332004659 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 83332004660 active site 83332004661 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 83332004662 substrate binding site [chemical binding]; other site 83332004663 glutamase interaction surface [polypeptide binding]; other site 83332004664 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 83332004665 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 83332004666 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 83332004667 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332004668 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 83332004669 catalytic triad [active] 83332004670 anthranilate synthase component I; Provisional; Region: PRK13571 83332004671 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 83332004672 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332004673 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 83332004674 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 83332004675 active site 83332004676 ribulose/triose binding site [chemical binding]; other site 83332004677 phosphate binding site [ion binding]; other site 83332004678 substrate (anthranilate) binding pocket [chemical binding]; other site 83332004679 product (indole) binding pocket [chemical binding]; other site 83332004680 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 83332004681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004682 catalytic residue [active] 83332004683 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 83332004684 substrate binding site [chemical binding]; other site 83332004685 active site 83332004686 catalytic residues [active] 83332004687 heterodimer interface [polypeptide binding]; other site 83332004688 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 83332004689 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 83332004690 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 83332004691 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 83332004692 pyruvate kinase; Provisional; Region: PRK06247 83332004693 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 83332004694 domain interfaces; other site 83332004695 active site 83332004696 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 83332004697 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 83332004698 active site 83332004699 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 83332004700 catalytic triad [active] 83332004701 dimer interface [polypeptide binding]; other site 83332004702 Uncharacterized conserved protein [Function unknown]; Region: COG2898 83332004703 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 83332004704 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 83332004705 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 83332004706 Walker A/P-loop; other site 83332004707 ATP binding site [chemical binding]; other site 83332004708 Q-loop/lid; other site 83332004709 ABC transporter signature motif; other site 83332004710 Walker B; other site 83332004711 D-loop; other site 83332004712 H-loop/switch region; other site 83332004713 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 83332004714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 83332004715 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 83332004716 Walker A/P-loop; other site 83332004717 ATP binding site [chemical binding]; other site 83332004718 Q-loop/lid; other site 83332004719 ABC transporter signature motif; other site 83332004720 Walker B; other site 83332004721 D-loop; other site 83332004722 H-loop/switch region; other site 83332004723 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 83332004724 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 83332004725 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 83332004726 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 83332004727 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 83332004728 cyclase homology domain; Region: CHD; cd07302 83332004729 nucleotidyl binding site; other site 83332004730 metal binding site [ion binding]; metal-binding site 83332004731 dimer interface [polypeptide binding]; other site 83332004732 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 83332004733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332004734 active site 83332004735 phosphorylation site [posttranslational modification] 83332004736 intermolecular recognition site; other site 83332004737 dimerization interface [polypeptide binding]; other site 83332004738 ANTAR domain; Region: ANTAR; pfam03861 83332004739 lipid-transfer protein; Provisional; Region: PRK06059 83332004740 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332004741 active site 83332004742 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332004743 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 83332004744 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332004745 DNA polymerase I; Provisional; Region: PRK05755 83332004746 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 83332004747 active site 83332004748 metal binding site 1 [ion binding]; metal-binding site 83332004749 putative 5' ssDNA interaction site; other site 83332004750 metal binding site 3; metal-binding site 83332004751 metal binding site 2 [ion binding]; metal-binding site 83332004752 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 83332004753 putative DNA binding site [nucleotide binding]; other site 83332004754 putative metal binding site [ion binding]; other site 83332004755 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 83332004756 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 83332004757 active site 83332004758 DNA binding site [nucleotide binding] 83332004759 catalytic site [active] 83332004760 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 83332004761 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 83332004762 RNA binding site [nucleotide binding]; other site 83332004763 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 83332004764 RNA binding site [nucleotide binding]; other site 83332004765 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 83332004766 RNA binding site [nucleotide binding]; other site 83332004767 S1 RNA binding domain; Region: S1; pfam00575 83332004768 RNA binding site [nucleotide binding]; other site 83332004769 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 83332004770 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 83332004771 CoA-binding site [chemical binding]; other site 83332004772 ATP-binding [chemical binding]; other site 83332004773 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 83332004774 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 83332004775 excinuclease ABC subunit B; Provisional; Region: PRK05298 83332004776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332004778 Walker A/P-loop; other site 83332004779 ATP binding site [chemical binding]; other site 83332004780 ATP binding site [chemical binding]; other site 83332004781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332004782 nucleotide binding region [chemical binding]; other site 83332004783 ATP-binding site [chemical binding]; other site 83332004784 Ultra-violet resistance protein B; Region: UvrB; pfam12344 83332004785 UvrB/uvrC motif; Region: UVR; pfam02151 83332004786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332004787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332004788 putative substrate translocation pore; other site 83332004789 Predicted membrane protein [Function unknown]; Region: COG5305 83332004790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332004791 Ligand Binding Site [chemical binding]; other site 83332004792 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332004793 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 83332004794 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 83332004795 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 83332004796 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 83332004797 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 83332004798 Predicted esterase [General function prediction only]; Region: COG0627 83332004799 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 83332004800 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 83332004801 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 83332004802 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 83332004803 dimer interface [polypeptide binding]; other site 83332004804 putative anticodon binding site; other site 83332004805 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332004806 motif 1; other site 83332004807 dimer interface [polypeptide binding]; other site 83332004808 active site 83332004809 motif 2; other site 83332004810 motif 3; other site 83332004811 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 83332004812 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 83332004813 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 83332004814 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 83332004815 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 83332004816 23S rRNA binding site [nucleotide binding]; other site 83332004817 L21 binding site [polypeptide binding]; other site 83332004818 L13 binding site [polypeptide binding]; other site 83332004819 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332004820 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 83332004821 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332004823 PE family; Region: PE; pfam00934 83332004824 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332004825 cyclase homology domain; Region: CHD; cd07302 83332004826 nucleotidyl binding site; other site 83332004827 metal binding site [ion binding]; metal-binding site 83332004828 dimer interface [polypeptide binding]; other site 83332004829 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 83332004830 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 83332004831 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 83332004832 dimer interface [polypeptide binding]; other site 83332004833 motif 1; other site 83332004834 active site 83332004835 motif 2; other site 83332004836 motif 3; other site 83332004837 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 83332004838 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 83332004839 putative tRNA-binding site [nucleotide binding]; other site 83332004840 B3/4 domain; Region: B3_4; pfam03483 83332004841 tRNA synthetase B5 domain; Region: B5; smart00874 83332004842 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 83332004843 dimer interface [polypeptide binding]; other site 83332004844 motif 1; other site 83332004845 motif 3; other site 83332004846 motif 2; other site 83332004847 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 83332004848 PE family; Region: PE; pfam00934 83332004849 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 83332004850 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 83332004851 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 83332004852 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 83332004853 heterotetramer interface [polypeptide binding]; other site 83332004854 active site pocket [active] 83332004855 cleavage site 83332004856 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 83332004857 feedback inhibition sensing region; other site 83332004858 homohexameric interface [polypeptide binding]; other site 83332004859 nucleotide binding site [chemical binding]; other site 83332004860 N-acetyl-L-glutamate binding site [chemical binding]; other site 83332004861 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332004862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332004863 inhibitor-cofactor binding pocket; inhibition site 83332004864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332004865 catalytic residue [active] 83332004866 ornithine carbamoyltransferase; Provisional; Region: PRK00779 83332004867 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 83332004868 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 83332004869 arginine repressor; Provisional; Region: PRK03341 83332004870 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 83332004871 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 83332004872 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 83332004873 ANP binding site [chemical binding]; other site 83332004874 Substrate Binding Site II [chemical binding]; other site 83332004875 Substrate Binding Site I [chemical binding]; other site 83332004876 argininosuccinate lyase; Region: argH; TIGR00838 83332004877 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 83332004878 active sites [active] 83332004879 tetramer interface [polypeptide binding]; other site 83332004880 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332004881 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332004882 malonyl-CoA binding site [chemical binding]; other site 83332004883 dimer interface [polypeptide binding]; other site 83332004884 active site 83332004885 product binding site; other site 83332004886 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004887 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004888 active site 83332004889 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004890 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332004891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004892 Enoylreductase; Region: PKS_ER; smart00829 83332004893 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004894 NAD(P) binding site [chemical binding]; other site 83332004895 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332004896 short chain dehydrogenase; Region: adh_short; pfam00106 83332004897 putative NADP binding site [chemical binding]; other site 83332004898 active site 83332004899 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004900 Erythronolide synthase docking; Region: Docking; pfam08990 83332004901 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332004902 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004903 active site 83332004904 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004905 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332004906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332004907 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332004908 Enoylreductase; Region: PKS_ER; smart00829 83332004909 NAD(P) binding site [chemical binding]; other site 83332004910 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332004911 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332004912 short chain dehydrogenase; Region: adh_short; pfam00106 83332004913 putative NADP binding site [chemical binding]; other site 83332004914 active site 83332004915 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004916 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332004917 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332004918 active site 83332004919 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332004920 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332004921 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 83332004922 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 83332004923 malonyl-CoA binding site [chemical binding]; other site 83332004924 dimer interface [polypeptide binding]; other site 83332004925 active site 83332004926 product binding site; other site 83332004927 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332004928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004929 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 83332004930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004931 ABC transporter signature motif; other site 83332004932 Walker B; other site 83332004933 D-loop; other site 83332004934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332004935 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 83332004936 ABC transporter; Region: ABC_tran_2; pfam12848 83332004937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332004938 Walker A/P-loop; other site 83332004939 ATP binding site [chemical binding]; other site 83332004940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 83332004941 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 83332004942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332004943 putative substrate translocation pore; other site 83332004944 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332004945 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332004946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332004947 dimerization interface [polypeptide binding]; other site 83332004948 putative DNA binding site [nucleotide binding]; other site 83332004949 putative Zn2+ binding site [ion binding]; other site 83332004950 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 83332004951 active site residue [active] 83332004952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332004953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332004954 ligand binding site [chemical binding]; other site 83332004955 flexible hinge region; other site 83332004956 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 83332004957 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 83332004958 putative catalytic residues [active] 83332004959 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 83332004960 catalytic residues [active] 83332004961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332004962 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332004963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332004964 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 83332004965 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 83332004966 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 83332004967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332004968 FeS/SAM binding site; other site 83332004969 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 83332004970 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 83332004971 acyl-CoA synthetase; Validated; Region: PRK07868 83332004972 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 83332004973 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332004974 acyl-activating enzyme (AAE) consensus motif; other site 83332004975 AMP binding site [chemical binding]; other site 83332004976 active site 83332004977 CoA binding site [chemical binding]; other site 83332004978 Uncharacterized conserved protein [Function unknown]; Region: COG2835 83332004979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332004980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332004981 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332004982 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332004983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332004984 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 83332004985 Walker A/P-loop; other site 83332004986 ATP binding site [chemical binding]; other site 83332004987 Q-loop/lid; other site 83332004988 ABC transporter signature motif; other site 83332004989 Walker B; other site 83332004990 D-loop; other site 83332004991 H-loop/switch region; other site 83332004992 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 83332004993 active site 83332004994 DNA binding site [nucleotide binding] 83332004995 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 83332004996 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 83332004997 active site 83332004998 HIGH motif; other site 83332004999 dimer interface [polypeptide binding]; other site 83332005000 KMSKS motif; other site 83332005001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332005002 RNA binding surface [nucleotide binding]; other site 83332005003 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005004 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 83332005005 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 83332005006 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 83332005007 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 83332005008 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 83332005009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332005010 RNA binding surface [nucleotide binding]; other site 83332005011 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 83332005012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005013 S-adenosylmethionine binding site [chemical binding]; other site 83332005014 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 83332005015 DNA repair protein RecN; Region: recN; TIGR00634 83332005016 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 83332005017 Walker A/P-loop; other site 83332005018 ATP binding site [chemical binding]; other site 83332005019 Q-loop/lid; other site 83332005020 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 83332005021 ABC transporter signature motif; other site 83332005022 Walker B; other site 83332005023 D-loop; other site 83332005024 H-loop/switch region; other site 83332005025 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 83332005026 Thiamine pyrophosphokinase; Region: TPK; cd07995 83332005027 active site 83332005028 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 83332005029 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 83332005030 CTP synthetase; Validated; Region: pyrG; PRK05380 83332005031 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 83332005032 Catalytic site [active] 83332005033 active site 83332005034 UTP binding site [chemical binding]; other site 83332005035 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 83332005036 active site 83332005037 putative oxyanion hole; other site 83332005038 catalytic triad [active] 83332005039 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 83332005040 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 83332005041 dimer interface [polypeptide binding]; other site 83332005042 ADP-ribose binding site [chemical binding]; other site 83332005043 active site 83332005044 nudix motif; other site 83332005045 metal binding site [ion binding]; metal-binding site 83332005046 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 83332005047 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 83332005048 active site 83332005049 Int/Topo IB signature motif; other site 83332005050 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005052 active site 83332005053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005054 S-adenosylmethionine binding site [chemical binding]; other site 83332005055 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 83332005056 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005057 PPE family; Region: PPE; pfam00823 83332005058 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005059 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005060 PPE family; Region: PPE; pfam00823 83332005061 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005062 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 83332005063 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332005064 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332005065 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 83332005066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332005067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332005068 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332005069 P-loop; other site 83332005070 Magnesium ion binding site [ion binding]; other site 83332005071 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 83332005072 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 83332005073 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 83332005074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332005075 RNA binding surface [nucleotide binding]; other site 83332005076 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 83332005077 active site 83332005078 cytidylate kinase; Provisional; Region: cmk; PRK00023 83332005079 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 83332005080 CMP-binding site; other site 83332005081 The sites determining sugar specificity; other site 83332005082 GTP-binding protein Der; Reviewed; Region: PRK03003 83332005083 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 83332005084 G1 box; other site 83332005085 GTP/Mg2+ binding site [chemical binding]; other site 83332005086 Switch I region; other site 83332005087 G2 box; other site 83332005088 Switch II region; other site 83332005089 G3 box; other site 83332005090 G4 box; other site 83332005091 G5 box; other site 83332005092 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 83332005093 G1 box; other site 83332005094 GTP/Mg2+ binding site [chemical binding]; other site 83332005095 Switch I region; other site 83332005096 G2 box; other site 83332005097 G3 box; other site 83332005098 Switch II region; other site 83332005099 G4 box; other site 83332005100 G5 box; other site 83332005101 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 83332005102 short chain dehydrogenase; Provisional; Region: PRK07060 83332005103 classical (c) SDRs; Region: SDR_c; cd05233 83332005104 NAD(P) binding site [chemical binding]; other site 83332005105 active site 83332005106 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 83332005107 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 83332005108 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 83332005109 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 83332005110 Cupin domain; Region: Cupin_2; cl17218 83332005111 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 83332005112 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332005113 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 83332005114 putative switch regulator; other site 83332005115 non-specific DNA interactions [nucleotide binding]; other site 83332005116 DNA binding site [nucleotide binding] 83332005117 sequence specific DNA binding site [nucleotide binding]; other site 83332005118 putative cAMP binding site [chemical binding]; other site 83332005119 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332005120 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 83332005121 putative active site [active] 83332005122 homotetrameric interface [polypeptide binding]; other site 83332005123 metal binding site [ion binding]; metal-binding site 83332005124 biotin carboxylase-like protein; Validated; Region: PRK06524 83332005125 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332005126 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332005127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005128 dimerization interface [polypeptide binding]; other site 83332005129 putative DNA binding site [nucleotide binding]; other site 83332005130 putative Zn2+ binding site [ion binding]; other site 83332005131 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332005132 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005133 Berberine and berberine like; Region: BBE; pfam08031 83332005134 TIGR03086 family protein; Region: TIGR03086 83332005135 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332005136 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332005137 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332005138 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 83332005139 NAD(P) binding site [chemical binding]; other site 83332005140 catalytic residues [active] 83332005141 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 83332005142 putative catalytic residue [active] 83332005143 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 83332005144 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332005145 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 83332005146 gating phenylalanine in ion channel; other site 83332005147 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 83332005148 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332005149 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 83332005150 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 83332005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005152 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 83332005153 putative substrate translocation pore; other site 83332005154 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 83332005155 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332005156 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 83332005157 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332005158 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 83332005159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332005160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 83332005161 putative active site [active] 83332005162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332005163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332005164 active site 83332005165 ATP binding site [chemical binding]; other site 83332005166 substrate binding site [chemical binding]; other site 83332005167 activation loop (A-loop); other site 83332005168 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 83332005169 Thioredoxin; Region: Thioredoxin_4; cl17273 83332005170 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 83332005171 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 83332005172 active site 83332005173 metal binding site [ion binding]; metal-binding site 83332005174 nudix motif; other site 83332005175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332005176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332005177 active site 83332005178 ATP binding site [chemical binding]; other site 83332005179 substrate binding site [chemical binding]; other site 83332005180 activation loop (A-loop); other site 83332005181 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005182 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005183 phosphopeptide binding site; other site 83332005184 Proline-rich; Region: Pro-rich; pfam15240 83332005185 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005186 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005187 phosphopeptide binding site; other site 83332005188 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 83332005189 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 83332005190 Walker A/P-loop; other site 83332005191 ATP binding site [chemical binding]; other site 83332005192 Q-loop/lid; other site 83332005193 ABC transporter signature motif; other site 83332005194 Walker B; other site 83332005195 D-loop; other site 83332005196 H-loop/switch region; other site 83332005197 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 83332005198 acyl-CoA synthetase; Provisional; Region: PRK13388 83332005199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332005200 acyl-activating enzyme (AAE) consensus motif; other site 83332005201 AMP binding site [chemical binding]; other site 83332005202 active site 83332005203 CoA binding site [chemical binding]; other site 83332005204 hypothetical protein; Provisional; Region: PRK06185 83332005205 FAD binding domain; Region: FAD_binding_3; pfam01494 83332005206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 83332005207 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005208 PPE family; Region: PPE; pfam00823 83332005209 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005210 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005211 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005212 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005213 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005214 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 83332005215 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332005216 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332005217 putative transposase OrfB; Reviewed; Region: PHA02517 83332005218 HTH-like domain; Region: HTH_21; pfam13276 83332005219 Integrase core domain; Region: rve; pfam00665 83332005220 Integrase core domain; Region: rve_3; pfam13683 83332005221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332005222 Transposase; Region: HTH_Tnp_1; cl17663 83332005223 Cutinase; Region: Cutinase; pfam01083 83332005224 PE family; Region: PE; pfam00934 83332005225 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332005226 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332005227 Uncharacterized conserved protein [Function unknown]; Region: COG0393 83332005228 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 83332005229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332005230 Transposase; Region: HTH_Tnp_1; cl17663 83332005231 putative transposase OrfB; Reviewed; Region: PHA02517 83332005232 HTH-like domain; Region: HTH_21; pfam13276 83332005233 Integrase core domain; Region: rve; pfam00665 83332005234 Integrase core domain; Region: rve_3; pfam13683 83332005235 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005237 active site 83332005238 Integrase core domain; Region: rve; pfam00665 83332005239 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 83332005240 putative homodimer interface [polypeptide binding]; other site 83332005241 putative homotetramer interface [polypeptide binding]; other site 83332005242 putative allosteric switch controlling residues; other site 83332005243 putative metal binding site [ion binding]; other site 83332005244 putative homodimer-homodimer interface [polypeptide binding]; other site 83332005245 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 83332005246 PE family; Region: PE; pfam00934 83332005247 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 83332005248 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 83332005249 dimer interface [polypeptide binding]; other site 83332005250 active site 83332005251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332005252 substrate binding site [chemical binding]; other site 83332005253 catalytic residue [active] 83332005254 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 83332005255 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 83332005256 metal binding site [ion binding]; metal-binding site 83332005257 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 83332005258 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005259 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 83332005260 ANTAR domain; Region: ANTAR; pfam03861 83332005261 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 83332005262 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332005263 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332005264 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332005265 FAD binding domain; Region: FAD_binding_4; pfam01565 83332005266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005267 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 83332005268 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005269 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 83332005270 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 83332005271 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 83332005272 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332005273 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332005274 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332005275 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332005276 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332005277 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332005278 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005279 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332005280 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005281 PPE family; Region: PPE; pfam00823 83332005282 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005283 PE family; Region: PE; pfam00934 83332005284 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005285 PPE family; Region: PPE; pfam00823 83332005286 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005287 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005288 PPE family; Region: PPE; pfam00823 83332005289 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005290 PE family; Region: PE; pfam00934 83332005291 Rv1792, (MTV049.14), len: 98 aa. EsxM, ESAT-6 like protein (see Gey Van Pittius et al., 2001), member of Mycobacterium tuberculosis QILSS family of proteins with Rv1038c, Rv1197, Rv3620c and Rv2347c. Has in-frame stop codon at 18074, no error could be found to account for this. Identical (apart from stop codon) to P96363|Rv1038c|MTCY10G2.11 putative ESAT-6 like protein 2 (98 aa), FASTA scores: opt: 389, E(): 5.8e-26, (100.0% identity in 58 aa overlap). Similar protein present in Mycobacterium leprae e.g. Q49946|MLCB1701.06C|AL049191 putative ESAT-6 like protein X (95 aa), FASTA scores: opt: 343, E(): 1.6e-17, (57.6% identity in 92 aa overlap). Seems to belong to the ESAT6 family. 83332005292 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332005293 EspG family; Region: ESX-1_EspG; pfam14011 83332005294 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332005295 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332005296 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332005297 catalytic residues [active] 83332005298 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 83332005299 active site 83332005300 catalytic residues [active] 83332005301 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332005302 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332005303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 83332005304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332005305 Walker A motif; other site 83332005306 ATP binding site [chemical binding]; other site 83332005307 Walker B motif; other site 83332005308 arginine finger; other site 83332005309 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005310 PPE family; Region: PPE; pfam00823 83332005311 PE-PPE domain; Region: PE-PPE; pfam08237 83332005312 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005313 PPE family; Region: PPE; pfam00823 83332005314 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005315 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005316 PPE family; Region: PPE; pfam00823 83332005317 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005318 PE family; Region: PE; pfam00934 83332005319 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005320 PE family; Region: PE; pfam00934 83332005321 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005322 PPE family; Region: PPE; pfam00823 83332005323 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005324 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005325 PPE family; Region: PPE; pfam00823 83332005326 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005327 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005328 PPE family; Region: PPE; pfam00823 83332005329 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332005330 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005331 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 83332005332 MgtC family; Region: MgtC; pfam02308 83332005333 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332005334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332005335 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 83332005336 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 83332005337 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 83332005338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005340 hypothetical protein; Validated; Region: PRK07121 83332005341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332005342 PE family; Region: PE; pfam00934 83332005343 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 83332005344 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 83332005345 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 83332005346 hypothetical protein; Provisional; Region: PRK05858 83332005347 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332005348 PYR/PP interface [polypeptide binding]; other site 83332005349 dimer interface [polypeptide binding]; other site 83332005350 TPP binding site [chemical binding]; other site 83332005351 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332005352 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 83332005353 TPP-binding site; other site 83332005354 dimer interface [polypeptide binding]; other site 83332005355 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 83332005356 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 83332005357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332005358 nucleotide binding region [chemical binding]; other site 83332005359 ATP-binding site [chemical binding]; other site 83332005360 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 83332005361 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332005362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332005363 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 83332005364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 83332005365 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 83332005366 lipoyl attachment site [posttranslational modification]; other site 83332005367 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332005368 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332005369 phosphopeptide binding site; other site 83332005370 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 83332005371 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 83332005372 DNA binding residues [nucleotide binding] 83332005373 Bifunctional nuclease; Region: DNase-RNase; pfam02577 83332005374 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 83332005375 DNA binding residues [nucleotide binding] 83332005376 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 83332005377 putative dimer interface [polypeptide binding]; other site 83332005378 glycine dehydrogenase; Provisional; Region: PRK05367 83332005379 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 83332005380 tetramer interface [polypeptide binding]; other site 83332005381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332005382 catalytic residue [active] 83332005383 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 83332005384 tetramer interface [polypeptide binding]; other site 83332005385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332005386 catalytic residue [active] 83332005387 haloalkane dehalogenase; Provisional; Region: PRK03204 83332005388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332005389 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 83332005390 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 83332005391 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 83332005392 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 83332005393 metal ion-dependent adhesion site (MIDAS); other site 83332005394 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 83332005395 active site 83332005396 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332005397 putative active site [active] 83332005398 PE family; Region: PE; pfam00934 83332005399 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332005400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332005401 FOG: CBS domain [General function prediction only]; Region: COG0517 83332005402 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 83332005403 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332005404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332005405 Transporter associated domain; Region: CorC_HlyC; smart01091 83332005406 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 83332005407 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 83332005408 active site 83332005409 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 83332005410 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 83332005411 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 83332005412 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 83332005413 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 83332005414 Predicted transcriptional regulator [Transcription]; Region: COG3682 83332005415 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 83332005416 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 83332005417 CoenzymeA binding site [chemical binding]; other site 83332005418 subunit interaction site [polypeptide binding]; other site 83332005419 PHB binding site; other site 83332005420 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 83332005421 alpha-gamma subunit interface [polypeptide binding]; other site 83332005422 beta-gamma subunit interface [polypeptide binding]; other site 83332005423 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 83332005424 gamma-beta subunit interface [polypeptide binding]; other site 83332005425 alpha-beta subunit interface [polypeptide binding]; other site 83332005426 urease subunit alpha; Reviewed; Region: ureC; PRK13206 83332005427 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 83332005428 subunit interactions [polypeptide binding]; other site 83332005429 active site 83332005430 flap region; other site 83332005431 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 83332005432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332005433 UreD urease accessory protein; Region: UreD; cl00530 83332005434 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 83332005435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332005436 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 83332005437 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332005438 classical (c) SDRs; Region: SDR_c; cd05233 83332005439 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 83332005440 NAD(P) binding site [chemical binding]; other site 83332005441 active site 83332005442 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 83332005443 sulfate transport protein; Provisional; Region: cysT; CHL00187 83332005444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005445 dimer interface [polypeptide binding]; other site 83332005446 conserved gate region; other site 83332005447 putative PBP binding loops; other site 83332005448 ABC-ATPase subunit interface; other site 83332005449 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 83332005450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332005451 Walker A/P-loop; other site 83332005452 ATP binding site [chemical binding]; other site 83332005453 Q-loop/lid; other site 83332005454 ABC transporter signature motif; other site 83332005455 Walker B; other site 83332005456 D-loop; other site 83332005457 H-loop/switch region; other site 83332005458 TOBE domain; Region: TOBE; pfam03459 83332005459 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 83332005460 Predicted membrane protein [Function unknown]; Region: COG2261 83332005461 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 83332005462 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 83332005463 putative NAD(P) binding site [chemical binding]; other site 83332005464 putative substrate binding site [chemical binding]; other site 83332005465 catalytic Zn binding site [ion binding]; other site 83332005466 structural Zn binding site [ion binding]; other site 83332005467 CAAX protease self-immunity; Region: Abi; pfam02517 83332005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 83332005469 MOSC domain; Region: MOSC; pfam03473 83332005470 short chain dehydrogenase; Provisional; Region: PRK07825 83332005471 classical (c) SDRs; Region: SDR_c; cd05233 83332005472 NAD(P) binding site [chemical binding]; other site 83332005473 active site 83332005474 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332005475 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332005476 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 83332005477 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332005478 active site 83332005479 hypothetical protein; Provisional; Region: PRK12320 83332005480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332005481 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 83332005482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332005483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332005484 Reductase C-terminal; Region: Reductase_C; pfam14759 83332005485 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 83332005486 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332005487 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 83332005488 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 83332005489 active site 83332005490 substrate binding site [chemical binding]; other site 83332005491 FMN binding site [chemical binding]; other site 83332005492 putative catalytic residues [active] 83332005493 Uncharacterized conserved protein [Function unknown]; Region: COG5579 83332005494 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332005495 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 83332005496 Ferritin-like domain; Region: Ferritin; pfam00210 83332005497 heme binding site [chemical binding]; other site 83332005498 ferroxidase pore; other site 83332005499 ferroxidase diiron center [ion binding]; other site 83332005500 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 83332005501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005502 putative substrate translocation pore; other site 83332005503 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 83332005504 23S rRNA interface [nucleotide binding]; other site 83332005505 L3 interface [polypeptide binding]; other site 83332005506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 83332005507 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332005508 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332005509 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332005510 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332005511 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 83332005512 short chain dehydrogenase; Provisional; Region: PRK08267 83332005513 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 83332005514 putative NAD(P) binding site [chemical binding]; other site 83332005515 active site 83332005516 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332005517 hydrophobic ligand binding site; other site 83332005518 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332005519 chorismate mutase; Provisional; Region: PRK09269 83332005520 chorismate mutase, putative; Region: CM_mono2; TIGR01806 83332005521 Predicted esterase [General function prediction only]; Region: COG0627 83332005522 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 83332005523 Leucine carboxyl methyltransferase; Region: LCM; cl01306 83332005524 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332005525 Uncharacterized conserved protein [Function unknown]; Region: COG2353 83332005526 Nitronate monooxygenase; Region: NMO; pfam03060 83332005527 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332005528 FMN binding site [chemical binding]; other site 83332005529 substrate binding site [chemical binding]; other site 83332005530 putative catalytic residue [active] 83332005531 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 83332005532 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332005533 catalytic Zn binding site [ion binding]; other site 83332005534 NAD(P) binding site [chemical binding]; other site 83332005535 structural Zn binding site [ion binding]; other site 83332005536 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332005537 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 83332005538 putative active site [active] 83332005539 dimerization interface [polypeptide binding]; other site 83332005540 putative tRNAtyr binding site [nucleotide binding]; other site 83332005541 Domain of unknown function DUF77; Region: DUF77; pfam01910 83332005542 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 83332005543 putative ADP-ribose binding site [chemical binding]; other site 83332005544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332005545 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332005546 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332005547 cyclase homology domain; Region: CHD; cd07302 83332005548 nucleotidyl binding site; other site 83332005549 metal binding site [ion binding]; metal-binding site 83332005550 dimer interface [polypeptide binding]; other site 83332005551 competence damage-inducible protein A; Provisional; Region: PRK00549 83332005552 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 83332005553 putative MPT binding site; other site 83332005554 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 83332005555 putative sialic acid transporter; Region: 2A0112; TIGR00891 83332005556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332005557 putative substrate translocation pore; other site 83332005558 Predicted membrane protein [Function unknown]; Region: COG1950 83332005559 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332005560 anti sigma factor interaction site; other site 83332005561 regulatory phosphorylation site [posttranslational modification]; other site 83332005562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332005563 FAD dependent oxidoreductase; Region: DAO; pfam01266 83332005564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332005565 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 83332005566 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 83332005567 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 83332005568 dimer interface [polypeptide binding]; other site 83332005569 active site 83332005570 heme binding site [chemical binding]; other site 83332005571 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 83332005572 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 83332005573 metal binding site 2 [ion binding]; metal-binding site 83332005574 putative DNA binding helix; other site 83332005575 metal binding site 1 [ion binding]; metal-binding site 83332005576 dimer interface [polypeptide binding]; other site 83332005577 structural Zn2+ binding site [ion binding]; other site 83332005578 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332005579 substrate binding site [chemical binding]; other site 83332005580 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332005581 substrate binding site [chemical binding]; other site 83332005582 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332005583 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 83332005584 putative NAD(P) binding site [chemical binding]; other site 83332005585 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332005586 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 83332005587 tetramer interface [polypeptide binding]; other site 83332005588 active site 83332005589 Mg2+/Mn2+ binding site [ion binding]; other site 83332005590 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 83332005591 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005592 PPE family; Region: PPE; pfam00823 83332005593 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005594 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005595 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005596 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005597 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005598 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005599 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005600 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005601 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005602 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005603 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005604 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332005605 PPE family; Region: PPE; pfam00823 83332005606 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005607 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005608 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005609 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332005610 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332005611 putative hydrophobic ligand binding site [chemical binding]; other site 83332005612 protein interface [polypeptide binding]; other site 83332005613 gate; other site 83332005614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 83332005615 putative acyl-acceptor binding pocket; other site 83332005616 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 83332005617 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 83332005618 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 83332005619 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332005620 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 83332005621 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332005622 acyl-activating enzyme (AAE) consensus motif; other site 83332005623 active site 83332005624 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 83332005625 Uncharacterized conserved protein [Function unknown]; Region: COG3361 83332005626 short chain dehydrogenase; Provisional; Region: PRK05867 83332005627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005628 NAD(P) binding site [chemical binding]; other site 83332005629 active site 83332005630 TIGR03085 family protein; Region: TIGR03085 83332005631 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332005632 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 83332005633 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332005634 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 83332005635 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 83332005636 conserved cys residue [active] 83332005637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332005638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332005639 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 83332005640 dimer interface [polypeptide binding]; other site 83332005641 catalytic triad [active] 83332005642 peroxidatic and resolving cysteines [active] 83332005643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332005644 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332005645 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332005646 active site 83332005647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332005648 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332005649 FAD binding site [chemical binding]; other site 83332005650 substrate binding site [chemical binding]; other site 83332005651 catalytic base [active] 83332005652 enoyl-CoA hydratase; Provisional; Region: PRK08290 83332005653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332005654 substrate binding site [chemical binding]; other site 83332005655 oxyanion hole (OAH) forming residues; other site 83332005656 trimer interface [polypeptide binding]; other site 83332005657 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 83332005658 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 83332005659 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332005660 catalytic loop [active] 83332005661 iron binding site [ion binding]; other site 83332005662 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 83332005663 FAD binding pocket [chemical binding]; other site 83332005664 FAD binding motif [chemical binding]; other site 83332005665 phosphate binding motif [ion binding]; other site 83332005666 beta-alpha-beta structure motif; other site 83332005667 NAD binding pocket [chemical binding]; other site 83332005668 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 83332005669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332005670 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332005671 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332005672 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 83332005673 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 83332005674 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 83332005675 dimerization interface [polypeptide binding]; other site 83332005676 active site 83332005677 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 83332005678 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 83332005679 putative NAD(P) binding site [chemical binding]; other site 83332005680 homodimer interface [polypeptide binding]; other site 83332005681 active site 83332005682 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332005683 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 83332005684 SEC-C motif; Region: SEC-C; cl19389 83332005685 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005686 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005687 active site 83332005688 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 83332005689 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 83332005690 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 83332005691 YjzC-like protein; Region: YjzC; pfam14168 83332005692 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 83332005693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005694 non-specific DNA binding site [nucleotide binding]; other site 83332005695 salt bridge; other site 83332005696 sequence-specific DNA binding site [nucleotide binding]; other site 83332005697 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 83332005698 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 83332005699 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332005700 putative active site [active] 83332005701 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332005702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332005705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332005706 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332005707 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332005708 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005709 mce related protein; Region: MCE; pfam02470 83332005710 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332005711 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005712 mce related protein; Region: MCE; pfam02470 83332005713 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005714 mce related protein; Region: MCE; pfam02470 83332005715 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005716 mce related protein; Region: MCE; pfam02470 83332005717 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 83332005718 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005719 mce related protein; Region: MCE; pfam02470 83332005720 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332005721 mce related protein; Region: MCE; pfam02470 83332005722 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332005723 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 83332005724 YacP-like NYN domain; Region: NYN_YacP; cl01491 83332005725 Peptidase family M48; Region: Peptidase_M48; pfam01435 83332005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005727 S-adenosylmethionine binding site [chemical binding]; other site 83332005728 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332005729 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 83332005730 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 83332005731 dimer interface [polypeptide binding]; other site 83332005732 putative radical transfer pathway; other site 83332005733 diiron center [ion binding]; other site 83332005734 tyrosyl radical; other site 83332005735 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332005736 putative active site [active] 83332005737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 83332005738 PE family; Region: PE; pfam00934 83332005739 Cutinase; Region: Cutinase; pfam01083 83332005740 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 83332005741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332005742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 83332005743 dimerization interface [polypeptide binding]; other site 83332005744 Lysine efflux permease [General function prediction only]; Region: COG1279 83332005745 Cellulose binding domain; Region: CBM_2; pfam00553 83332005746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005747 S-adenosylmethionine binding site [chemical binding]; other site 83332005748 Uncharacterized conserved protein [Function unknown]; Region: COG5654 83332005749 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 83332005750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005751 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332005752 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332005753 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 83332005754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332005755 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 83332005756 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332005757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005758 dimerization interface [polypeptide binding]; other site 83332005759 putative DNA binding site [nucleotide binding]; other site 83332005760 putative Zn2+ binding site [ion binding]; other site 83332005761 Hemerythrin-like domain; Region: Hr-like; cd12108 83332005762 Fe binding site [ion binding]; other site 83332005763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005764 Ligand Binding Site [chemical binding]; other site 83332005765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005766 Ligand Binding Site [chemical binding]; other site 83332005767 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 83332005768 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 83332005769 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332005770 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 83332005771 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332005772 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 83332005773 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 83332005774 tetramer interface [polypeptide binding]; other site 83332005775 active site 83332005776 Mg2+/Mn2+ binding site [ion binding]; other site 83332005777 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332005778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332005779 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 83332005780 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 83332005781 homotetramer interface [polypeptide binding]; other site 83332005782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 83332005783 NAD binding site [chemical binding]; other site 83332005784 homodimer interface [polypeptide binding]; other site 83332005785 active site 83332005786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005787 S-adenosylmethionine binding site [chemical binding]; other site 83332005788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 83332005789 Predicted kinase [General function prediction only]; Region: COG0645 83332005790 AAA domain; Region: AAA_33; pfam13671 83332005791 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005792 Ligand Binding Site [chemical binding]; other site 83332005793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005794 Ligand Binding Site [chemical binding]; other site 83332005795 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 83332005796 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 83332005797 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 83332005798 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 83332005799 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 83332005800 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 83332005801 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 83332005802 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 83332005803 Ferredoxin [Energy production and conversion]; Region: COG1146 83332005804 4Fe-4S binding domain; Region: Fer4; pfam00037 83332005805 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 83332005806 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332005807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332005808 Walker A motif; other site 83332005809 ATP binding site [chemical binding]; other site 83332005810 Walker B motif; other site 83332005811 arginine finger; other site 83332005812 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 83332005813 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332005814 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332005815 putative active site [active] 83332005816 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332005817 MarR family; Region: MarR_2; pfam12802 83332005818 Phage envelope protein [General function prediction only]; Region: COG5562 83332005819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332005820 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332005821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332005822 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332005823 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332005824 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332005825 active site 83332005826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332005828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005829 non-specific DNA binding site [nucleotide binding]; other site 83332005830 salt bridge; other site 83332005831 sequence-specific DNA binding site [nucleotide binding]; other site 83332005832 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 83332005833 Uncharacterized conserved protein [Function unknown]; Region: COG2442 83332005834 Predicted helicase [General function prediction only]; Region: COG4889 83332005835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332005836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332005837 non-specific DNA binding site [nucleotide binding]; other site 83332005838 salt bridge; other site 83332005839 sequence-specific DNA binding site [nucleotide binding]; other site 83332005840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 83332005841 Rv2023A, len: 152 aa. Hypothetical unknown protein (pseudogene), equivalent to the C-terminus of Q8VJS0|MT2080 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (225 aa), FASTA scores: opt: 1028, E(): 3.6e-66,(99.342% identity in 152 aa overlap) and C-terminus of Mb2047c hypothetical protein from Mycobacterium bovis (225 aa). And N-terminal part equivalent to the C-terminus of Q9XB17 hypothetical 15.5 kDa protein from Mycobacterium bovis BCG (131 aa), FASTA scores: opt: 409, E(): 4.2e-22,(98.276% identity in 58 aa overlap). Note that a deletion of DNA (RvD1 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below). 83332005842 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 83332005843 DEAD-like helicases superfamily; Region: DEXDc; smart00487 83332005844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332005845 ATP binding site [chemical binding]; other site 83332005846 putative Mg++ binding site [ion binding]; other site 83332005847 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 83332005848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005849 Ligand Binding Site [chemical binding]; other site 83332005850 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005851 Ligand Binding Site [chemical binding]; other site 83332005852 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 83332005853 GAF domain; Region: GAF_3; pfam13492 83332005854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 83332005855 Histidine kinase; Region: HisKA_3; pfam07730 83332005856 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332005857 Ligand Binding Site [chemical binding]; other site 83332005858 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 83332005859 putative substrate binding site [chemical binding]; other site 83332005860 putative ATP binding site [chemical binding]; other site 83332005861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332005862 active site 83332005863 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 83332005864 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 83332005865 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 83332005866 putative dimer interface [polypeptide binding]; other site 83332005867 Nitroreductase family; Region: Nitroreductase; pfam00881 83332005868 dimer interface [polypeptide binding]; other site 83332005869 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 83332005870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332005871 putative DNA binding site [nucleotide binding]; other site 83332005872 dimerization interface [polypeptide binding]; other site 83332005873 putative Zn2+ binding site [ion binding]; other site 83332005874 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 83332005875 putative hydrophobic ligand binding site [chemical binding]; other site 83332005876 CLM binding site; other site 83332005877 L1 loop; other site 83332005878 DNA binding site [nucleotide binding] 83332005879 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332005880 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332005881 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 83332005882 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332005883 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 83332005884 active site 83332005885 nucleophile elbow; other site 83332005886 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 83332005887 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 83332005888 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332005889 Walker A/P-loop; other site 83332005890 ATP binding site [chemical binding]; other site 83332005891 Q-loop/lid; other site 83332005892 ABC transporter signature motif; other site 83332005893 Walker B; other site 83332005894 D-loop; other site 83332005895 H-loop/switch region; other site 83332005896 TOBE domain; Region: TOBE_2; pfam08402 83332005897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332005898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005899 dimer interface [polypeptide binding]; other site 83332005900 conserved gate region; other site 83332005901 putative PBP binding loops; other site 83332005902 ABC-ATPase subunit interface; other site 83332005903 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 83332005904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332005905 dimer interface [polypeptide binding]; other site 83332005906 conserved gate region; other site 83332005907 putative PBP binding loops; other site 83332005908 ABC-ATPase subunit interface; other site 83332005909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332005910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332005911 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 83332005912 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 83332005913 catalytic triad [active] 83332005914 metal binding site [ion binding]; metal-binding site 83332005915 conserved cis-peptide bond; other site 83332005916 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 83332005917 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 83332005918 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332005919 substrate binding pocket [chemical binding]; other site 83332005920 catalytic triad [active] 83332005921 hypothetical protein; Provisional; Region: PRK05865 83332005922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005923 NAD(P) binding site [chemical binding]; other site 83332005924 active site 83332005925 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 83332005926 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332005927 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332005928 active site 83332005929 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332005930 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332005931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005932 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332005933 Enoylreductase; Region: PKS_ER; smart00829 83332005934 NAD(P) binding site [chemical binding]; other site 83332005935 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332005936 short chain dehydrogenase; Region: adh_short; pfam00106 83332005937 putative NADP binding site [chemical binding]; other site 83332005938 active site 83332005939 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332005940 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332005941 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332005942 active site 83332005943 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332005944 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332005945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332005946 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332005947 Enoylreductase; Region: PKS_ER; smart00829 83332005948 NAD(P) binding site [chemical binding]; other site 83332005949 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332005950 short chain dehydrogenase; Region: adh_short; pfam00106 83332005951 putative NADP binding site [chemical binding]; other site 83332005952 active site 83332005953 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332005954 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 83332005955 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332005956 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 83332005957 putative active site [active] 83332005958 catalytic triad [active] 83332005959 putative dimer interface [polypeptide binding]; other site 83332005960 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 83332005961 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 83332005962 Ligand binding site; other site 83332005963 Putative Catalytic site; other site 83332005964 DXD motif; other site 83332005965 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 83332005966 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 83332005967 active site 83332005968 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 83332005969 Dienelactone hydrolase family; Region: DLH; pfam01738 83332005970 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332005971 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 83332005972 30S ribosomal protein S18; Provisional; Region: PRK13401 83332005973 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 83332005974 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 83332005975 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 83332005976 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 83332005977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 83332005978 intersubunit interface [polypeptide binding]; other site 83332005979 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 83332005980 ABC-ATPase subunit interface; other site 83332005981 putative PBP binding regions; other site 83332005982 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 83332005983 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 83332005984 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 83332005985 PemK-like protein; Region: PemK; pfam02452 83332005986 precorrin-3B synthase; Region: CobG; TIGR02435 83332005987 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332005988 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 83332005989 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 83332005990 active site 83332005991 SAM binding site [chemical binding]; other site 83332005992 homodimer interface [polypeptide binding]; other site 83332005993 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 83332005994 active site 83332005995 SAM binding site [chemical binding]; other site 83332005996 homodimer interface [polypeptide binding]; other site 83332005997 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332005998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332005999 S-adenosylmethionine binding site [chemical binding]; other site 83332006000 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 83332006001 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 83332006002 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 83332006003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332006004 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 83332006005 DNA binding residues [nucleotide binding] 83332006006 precorrin-6x reductase; Region: precor6x_red; TIGR00715 83332006007 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 83332006008 active site 83332006009 SAM binding site [chemical binding]; other site 83332006010 homodimer interface [polypeptide binding]; other site 83332006011 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 83332006012 active site 83332006013 putative homodimer interface [polypeptide binding]; other site 83332006014 SAM binding site [chemical binding]; other site 83332006015 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 83332006016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332006017 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332006018 NAD(P) binding site [chemical binding]; other site 83332006019 active site 83332006020 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332006021 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 83332006022 putative active site [active] 83332006023 catalytic site [active] 83332006024 putative metal binding site [ion binding]; other site 83332006025 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 83332006026 ligand binding surface [chemical binding]; other site 83332006027 Translocation protein Sec62; Region: Sec62; cl02170 83332006028 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 83332006029 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332006030 putative transposase OrfB; Reviewed; Region: PHA02517 83332006031 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332006032 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332006033 active site 83332006034 ATP binding site [chemical binding]; other site 83332006035 substrate binding site [chemical binding]; other site 83332006036 activation loop (A-loop); other site 83332006037 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332006038 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 83332006039 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 83332006040 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 83332006041 active site 83332006042 5'-3' exonuclease; Region: 53EXOc; smart00475 83332006043 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 83332006044 active site 83332006045 metal binding site 1 [ion binding]; metal-binding site 83332006046 putative 5' ssDNA interaction site; other site 83332006047 metal binding site 3; metal-binding site 83332006048 metal binding site 2 [ion binding]; metal-binding site 83332006049 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 83332006050 putative DNA binding site [nucleotide binding]; other site 83332006051 putative metal binding site [ion binding]; other site 83332006052 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332006053 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 83332006054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332006055 ATP binding site [chemical binding]; other site 83332006056 putative Mg++ binding site [ion binding]; other site 83332006057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332006058 nucleotide binding region [chemical binding]; other site 83332006059 ATP-binding site [chemical binding]; other site 83332006060 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 83332006061 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 83332006062 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 83332006063 Predicted transcriptional regulator [Transcription]; Region: COG2378 83332006064 WYL domain; Region: WYL; pfam13280 83332006065 Predicted transcriptional regulator [Transcription]; Region: COG2378 83332006066 WYL domain; Region: WYL; pfam13280 83332006067 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 83332006068 Rv2098c, (MTCY49.38c), len: 434 aa. PE_PGRS36,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Frameshifted near N-terminus (see Rv2099c|PE21). 83332006069 Rv2099c, (MTCY49.39c), len: 58 aa. PE21, Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002); 5'-end of Rv2098c|PE_PGRS36|MTCY49.38c, then frameshifts. Sequence has been checked, no errors found. 83332006070 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332006071 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332006072 active site 83332006073 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 83332006074 SNF2 Helicase protein; Region: DUF3670; pfam12419 83332006075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332006076 ATP binding site [chemical binding]; other site 83332006077 putative Mg++ binding site [ion binding]; other site 83332006078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332006079 nucleotide binding region [chemical binding]; other site 83332006080 ATP-binding site [chemical binding]; other site 83332006081 Uncharacterized conserved protein [Function unknown]; Region: COG4279 83332006082 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332006083 putative active site [active] 83332006084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006085 Transposase; Region: HTH_Tnp_1; cl17663 83332006086 putative transposase OrfB; Reviewed; Region: PHA02517 83332006087 HTH-like domain; Region: HTH_21; pfam13276 83332006088 Integrase core domain; Region: rve; pfam00665 83332006089 Integrase core domain; Region: rve_3; pfam13683 83332006090 PE family; Region: PE; pfam00934 83332006091 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006092 PPE family; Region: PPE; pfam00823 83332006093 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 83332006094 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 83332006095 active site 83332006096 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 83332006097 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 83332006098 active site 83332006099 Pup-like protein; Region: Pup; pfam05639 83332006100 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 83332006101 proteasome ATPase; Region: pup_AAA; TIGR03689 83332006102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332006103 Walker A motif; other site 83332006104 ATP binding site [chemical binding]; other site 83332006105 Walker B motif; other site 83332006106 arginine finger; other site 83332006107 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 83332006108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 83332006109 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 83332006110 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 83332006111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332006112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332006113 S-adenosylmethionine binding site [chemical binding]; other site 83332006114 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332006115 Predicted membrane protein [Function unknown]; Region: COG3918 83332006116 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 83332006117 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 83332006118 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 83332006119 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 83332006120 homodimer interface [polypeptide binding]; other site 83332006121 putative metal binding site [ion binding]; other site 83332006122 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006123 PPE family; Region: PPE; pfam00823 83332006124 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 83332006125 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 83332006126 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 83332006127 substrate binding pocket [chemical binding]; other site 83332006128 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 83332006129 B12 binding site [chemical binding]; other site 83332006130 cobalt ligand [ion binding]; other site 83332006131 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 83332006132 PAC2 family; Region: PAC2; pfam09754 83332006133 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 83332006134 short chain dehydrogenase; Provisional; Region: PRK05872 83332006135 classical (c) SDRs; Region: SDR_c; cd05233 83332006136 NAD(P) binding site [chemical binding]; other site 83332006137 active site 83332006138 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 83332006139 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 83332006140 active site 83332006141 HIGH motif; other site 83332006142 KMSKS motif; other site 83332006143 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 83332006144 putative tRNA binding surface [nucleotide binding]; other site 83332006145 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 83332006146 active site 83332006147 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332006148 conserved hypothetical protein; Region: TIGR03843 83332006149 conserved hypothetical protein; Region: TIGR03847 83332006150 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006151 catalytic core [active] 83332006152 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 83332006153 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 83332006154 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 83332006155 quinone interaction residues [chemical binding]; other site 83332006156 active site 83332006157 catalytic residues [active] 83332006158 FMN binding site [chemical binding]; other site 83332006159 substrate binding site [chemical binding]; other site 83332006160 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 83332006161 substrate binding site [chemical binding]; other site 83332006162 hypothetical protein; Provisional; Region: PRK07906 83332006163 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 83332006164 putative metal binding site [ion binding]; other site 83332006165 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 83332006166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 83332006167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332006168 active site 83332006169 DivIVA protein; Region: DivIVA; pfam05103 83332006170 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 83332006171 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 83332006172 Predicted integral membrane protein [Function unknown]; Region: COG0762 83332006173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 83332006174 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 83332006175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332006176 catalytic residue [active] 83332006177 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 83332006178 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 83332006179 nucleotide binding site [chemical binding]; other site 83332006180 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 83332006181 SulA interaction site; other site 83332006182 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 83332006183 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 83332006184 Cell division protein FtsQ; Region: FtsQ; pfam03799 83332006185 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 83332006186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 83332006187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006189 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 83332006190 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 83332006191 active site 83332006192 homodimer interface [polypeptide binding]; other site 83332006193 cell division protein FtsW; Region: ftsW; TIGR02614 83332006194 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 83332006195 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006196 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006197 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 83332006198 Mg++ binding site [ion binding]; other site 83332006199 putative catalytic motif [active] 83332006200 putative substrate binding site [chemical binding]; other site 83332006201 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 83332006202 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 83332006203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006205 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 83332006206 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 83332006207 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332006208 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332006209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332006210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332006211 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332006212 PE family; Region: PE; pfam00934 83332006213 GAGA binding protein-like family; Region: GAGA_bind; pfam06217 83332006214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332006215 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 83332006216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332006217 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 83332006218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 83332006219 MraZ protein; Region: MraZ; pfam02381 83332006220 MraZ protein; Region: MraZ; pfam02381 83332006221 putative transposase OrfB; Reviewed; Region: PHA02517 83332006222 HTH-like domain; Region: HTH_21; pfam13276 83332006223 Integrase core domain; Region: rve; pfam00665 83332006224 Integrase core domain; Region: rve_3; pfam13683 83332006225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006226 Transposase; Region: HTH_Tnp_1; cl17663 83332006227 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 83332006228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 83332006229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 83332006230 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 83332006231 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332006232 substrate binding pocket [chemical binding]; other site 83332006233 chain length determination region; other site 83332006234 substrate-Mg2+ binding site; other site 83332006235 catalytic residues [active] 83332006236 aspartate-rich region 1; other site 83332006237 active site lid residues [active] 83332006238 aspartate-rich region 2; other site 83332006239 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 83332006240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332006241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332006242 active site 83332006243 ATP binding site [chemical binding]; other site 83332006244 substrate binding site [chemical binding]; other site 83332006245 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 83332006246 substrate binding site [chemical binding]; other site 83332006247 activation loop (A-loop); other site 83332006248 activation loop (A-loop); other site 83332006249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332006250 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332006251 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 83332006252 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 83332006253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332006254 putative acyl-acceptor binding pocket; other site 83332006255 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332006256 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 83332006257 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 83332006258 putative hydrophobic ligand binding site [chemical binding]; other site 83332006259 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332006260 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 83332006261 acyl-activating enzyme (AAE) consensus motif; other site 83332006262 putative AMP binding site [chemical binding]; other site 83332006263 putative active site [active] 83332006264 putative CoA binding site [chemical binding]; other site 83332006265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332006266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332006267 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 83332006268 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 83332006269 NlpC/P60 family; Region: NLPC_P60; pfam00877 83332006270 hypothetical protein; Validated; Region: PRK07883 83332006271 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 83332006272 active site 83332006273 catalytic site [active] 83332006274 substrate binding site [chemical binding]; other site 83332006275 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 83332006276 GIY-YIG motif/motif A; other site 83332006277 active site 83332006278 catalytic site [active] 83332006279 putative DNA binding site [nucleotide binding]; other site 83332006280 metal binding site [ion binding]; metal-binding site 83332006281 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 83332006282 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 83332006283 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 83332006284 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 83332006285 Subunit I/III interface [polypeptide binding]; other site 83332006286 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 83332006287 cytochrome c-550; Provisional; Region: psbV; cl17239 83332006288 Cytochrome c; Region: Cytochrom_C; pfam00034 83332006289 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 83332006290 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 83332006291 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 83332006292 iron-sulfur cluster [ion binding]; other site 83332006293 [2Fe-2S] cluster binding site [ion binding]; other site 83332006294 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 83332006295 heme bH binding site [chemical binding]; other site 83332006296 Qi binding site; other site 83332006297 intrachain domain interface; other site 83332006298 heme bL binding site [chemical binding]; other site 83332006299 interchain domain interface [polypeptide binding]; other site 83332006300 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 83332006301 Qo binding site; other site 83332006302 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 83332006303 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 83332006304 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 83332006305 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 83332006306 Cupredoxin superfamily; Region: Cupredoxin; cl19115 83332006307 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 83332006308 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 83332006309 dimer interface [polypeptide binding]; other site 83332006310 active site 83332006311 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 83332006312 Ligand Binding Site [chemical binding]; other site 83332006313 Molecular Tunnel; other site 83332006314 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 83332006315 substrate binding site [chemical binding]; other site 83332006316 ATP binding site [chemical binding]; other site 83332006317 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 83332006318 Glycerate kinase family; Region: Gly_kinase; pfam02595 83332006319 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 83332006320 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 83332006321 putative dimer interface [polypeptide binding]; other site 83332006322 active site pocket [active] 83332006323 putative cataytic base [active] 83332006324 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 83332006325 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 83332006326 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 83332006327 homodimer interface [polypeptide binding]; other site 83332006328 substrate-cofactor binding pocket; other site 83332006329 catalytic residue [active] 83332006330 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 83332006331 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 83332006332 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 83332006333 cyclase homology domain; Region: CHD; cd07302 83332006334 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332006335 nucleotidyl binding site; other site 83332006336 metal binding site [ion binding]; metal-binding site 83332006337 dimer interface [polypeptide binding]; other site 83332006338 multifunctional aminopeptidase A; Provisional; Region: PRK00913 83332006339 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 83332006340 interface (dimer of trimers) [polypeptide binding]; other site 83332006341 Substrate-binding/catalytic site; other site 83332006342 Zn-binding sites [ion binding]; other site 83332006343 short chain dehydrogenase; Validated; Region: PRK05855 83332006344 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332006345 classical (c) SDRs; Region: SDR_c; cd05233 83332006346 NAD(P) binding site [chemical binding]; other site 83332006347 active site 83332006348 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 83332006349 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332006350 E3 interaction surface; other site 83332006351 lipoyl attachment site [posttranslational modification]; other site 83332006352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332006353 E3 interaction surface; other site 83332006354 lipoyl attachment site [posttranslational modification]; other site 83332006355 e3 binding domain; Region: E3_binding; pfam02817 83332006356 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332006357 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 83332006358 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 83332006359 putative NAD(P) binding site [chemical binding]; other site 83332006360 putative active site [active] 83332006361 lipoate-protein ligase B; Provisional; Region: PRK14345 83332006362 lipoyl synthase; Provisional; Region: PRK05481 83332006363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332006364 FeS/SAM binding site; other site 83332006365 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 83332006366 RDD family; Region: RDD; pfam06271 83332006367 glutamine synthetase, type I; Region: GlnA; TIGR00653 83332006368 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332006369 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332006370 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 83332006371 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332006372 metal binding triad; other site 83332006373 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332006374 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332006375 metal binding triad; other site 83332006376 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332006377 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332006378 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332006379 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332006380 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Region: ACP_syn_III; cl19161 83332006381 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 83332006382 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332006383 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 83332006384 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332006385 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332006386 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332006387 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 83332006388 oligomerization interface [polypeptide binding]; other site 83332006389 active site 83332006390 metal binding site [ion binding]; metal-binding site 83332006391 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 83332006392 putative active site; other site 83332006393 putative metal binding residues [ion binding]; other site 83332006394 signature motif; other site 83332006395 putative triphosphate binding site [ion binding]; other site 83332006396 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 83332006397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 83332006398 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 83332006399 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 83332006400 RNA/DNA hybrid binding site [nucleotide binding]; other site 83332006401 active site 83332006402 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006403 catalytic core [active] 83332006404 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 83332006405 Putative zinc ribbon domain; Region: DUF164; pfam02591 83332006406 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 83332006407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 83332006408 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 83332006409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332006410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006411 homodimer interface [polypeptide binding]; other site 83332006412 catalytic residue [active] 83332006413 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 83332006414 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 83332006415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332006416 active site 83332006417 motif I; other site 83332006418 motif II; other site 83332006419 Low molecular weight phosphatase family; Region: LMWPc; cd00115 83332006420 active site 83332006421 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 83332006422 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 83332006423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 83332006424 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332006425 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 83332006426 dimer interface [polypeptide binding]; other site 83332006427 catalytic triad [active] 83332006428 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 83332006429 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 83332006430 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 83332006431 dimer interface [polypeptide binding]; other site 83332006432 TPP-binding site [chemical binding]; other site 83332006433 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 83332006434 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332006435 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332006436 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332006437 acyl carrier protein; Provisional; Region: acpP; PRK00982 83332006438 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 83332006439 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 83332006440 dimer interface [polypeptide binding]; other site 83332006441 active site 83332006442 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 83332006443 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 83332006444 dimer interface [polypeptide binding]; other site 83332006445 active site 83332006446 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332006447 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332006448 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332006449 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332006450 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332006451 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 83332006452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332006453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332006454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332006455 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332006456 FAD binding domain; Region: FAD_binding_4; pfam01565 83332006457 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 83332006458 diacylglycerol kinase; Reviewed; Region: PRK11914 83332006459 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 83332006460 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 83332006461 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332006462 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332006463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332006464 S-adenosylmethionine binding site [chemical binding]; other site 83332006465 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 83332006466 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332006467 NAD binding site [chemical binding]; other site 83332006468 catalytic Zn binding site [ion binding]; other site 83332006469 substrate binding site [chemical binding]; other site 83332006470 structural Zn binding site [ion binding]; other site 83332006471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332006472 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 83332006473 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332006474 active site 83332006475 dimer interface [polypeptide binding]; other site 83332006476 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 83332006477 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 83332006478 catalytic triad [active] 83332006479 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332006480 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 83332006481 putative NAD(P) binding site [chemical binding]; other site 83332006482 active site 83332006483 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 83332006484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 83332006485 nucleotide binding site [chemical binding]; other site 83332006486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006487 putative substrate translocation pore; other site 83332006488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332006489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006490 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 83332006491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006492 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 83332006493 dimerization interface [polypeptide binding]; other site 83332006494 ATP binding site [chemical binding]; other site 83332006495 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 83332006496 Septum formation; Region: Septum_form; pfam13845 83332006497 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 83332006498 Predicted membrane protein [Function unknown]; Region: COG2149 83332006499 Domain of unknown function (DUF202); Region: DUF202; pfam02656 83332006500 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332006501 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 83332006502 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332006503 putative active site [active] 83332006504 catalytic site [active] 83332006505 putative metal binding site [ion binding]; other site 83332006506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006507 Transposase; Region: HTH_Tnp_1; cl17663 83332006508 putative transposase OrfB; Reviewed; Region: PHA02517 83332006509 HTH-like domain; Region: HTH_21; pfam13276 83332006510 Integrase core domain; Region: rve; pfam00665 83332006511 Integrase core domain; Region: rve_3; pfam13683 83332006512 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332006513 FAD binding domain; Region: FAD_binding_4; pfam01565 83332006514 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 83332006515 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 83332006516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 83332006517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 83332006518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 83332006519 dimerization interface [polypeptide binding]; other site 83332006520 Mediator of RNA pol II transcription subunit 19; Region: Med19; pfam10278 83332006521 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332006522 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 83332006523 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332006524 Secretory lipase; Region: LIP; pfam03583 83332006525 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332006526 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332006527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 83332006528 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 83332006529 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 83332006530 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 83332006531 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332006532 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332006533 active site residue [active] 83332006534 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332006535 active site residue [active] 83332006536 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 83332006537 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 83332006538 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 83332006539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332006540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006541 homodimer interface [polypeptide binding]; other site 83332006542 catalytic residue [active] 83332006543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 83332006544 haloalkane dehalogenase; Provisional; Region: PRK00870 83332006545 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332006546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 83332006547 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 83332006548 active site 83332006549 catalytic tetrad [active] 83332006550 heat shock protein 90; Provisional; Region: PRK05218 83332006551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332006552 ATP binding site [chemical binding]; other site 83332006553 Mg2+ binding site [ion binding]; other site 83332006554 G-X-G motif; other site 83332006555 Hsp90 protein; Region: HSP90; pfam00183 83332006556 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332006557 Cutinase; Region: Cutinase; pfam01083 83332006558 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 83332006559 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332006560 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 83332006561 Condensation domain; Region: Condensation; cl19241 83332006562 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332006563 Uncharacterized conserved protein [Function unknown]; Region: COG0398 83332006564 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332006565 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332006566 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332006567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 83332006568 Uncharacterized conserved protein [Function unknown]; Region: COG2442 83332006569 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 83332006570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332006571 DNA binding site [nucleotide binding] 83332006572 active site 83332006573 Int/Topo IB signature motif; other site 83332006574 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332006575 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 83332006576 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332006577 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 83332006578 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 83332006579 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 83332006580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006581 dimer interface [polypeptide binding]; other site 83332006582 putative PBP binding loops; other site 83332006583 ABC-ATPase subunit interface; other site 83332006584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332006585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006586 dimer interface [polypeptide binding]; other site 83332006587 conserved gate region; other site 83332006588 putative PBP binding loops; other site 83332006589 ABC-ATPase subunit interface; other site 83332006590 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332006591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 83332006592 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332006593 Ligand Binding Site [chemical binding]; other site 83332006594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332006595 Ligand Binding Site [chemical binding]; other site 83332006596 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 83332006597 amino acid transporter; Region: 2A0306; TIGR00909 83332006598 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 83332006599 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 83332006600 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332006601 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332006602 catalytic residue [active] 83332006603 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332006604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332006605 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 83332006606 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 83332006607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332006608 putative DNA binding site [nucleotide binding]; other site 83332006609 putative Zn2+ binding site [ion binding]; other site 83332006610 AsnC family; Region: AsnC_trans_reg; pfam01037 83332006611 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 83332006612 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 83332006613 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 83332006614 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 83332006615 Walker A/P-loop; other site 83332006616 ATP binding site [chemical binding]; other site 83332006617 Q-loop/lid; other site 83332006618 ABC transporter signature motif; other site 83332006619 Walker B; other site 83332006620 D-loop; other site 83332006621 H-loop/switch region; other site 83332006622 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 83332006623 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 83332006624 Walker A/P-loop; other site 83332006625 ATP binding site [chemical binding]; other site 83332006626 Q-loop/lid; other site 83332006627 ABC transporter signature motif; other site 83332006628 Walker B; other site 83332006629 D-loop; other site 83332006630 H-loop/switch region; other site 83332006631 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332006632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 83332006633 PE family; Region: PE; pfam00934 83332006634 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 83332006635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006636 putative substrate translocation pore; other site 83332006637 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332006638 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 83332006639 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 83332006640 conserved FAD binding motif [chemical binding]; other site 83332006641 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 83332006642 malate dehydrogenase; Provisional; Region: PRK13529 83332006643 Malic enzyme, N-terminal domain; Region: malic; pfam00390 83332006644 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 83332006645 NAD(P) binding site [chemical binding]; other site 83332006646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332006647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332006648 putative substrate translocation pore; other site 83332006649 cysteine synthase; Region: PLN02565 83332006650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 83332006651 dimer interface [polypeptide binding]; other site 83332006652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332006653 catalytic residue [active] 83332006654 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 83332006655 serine O-acetyltransferase; Region: cysE; TIGR01172 83332006656 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 83332006657 trimer interface [polypeptide binding]; other site 83332006658 active site 83332006659 substrate binding site [chemical binding]; other site 83332006660 CoA binding site [chemical binding]; other site 83332006661 Nitroreductase family; Region: Nitroreductase; pfam00881 83332006662 hypothetical protein; Validated; Region: PRK08223 83332006663 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 83332006664 ATP binding site [chemical binding]; other site 83332006665 substrate interface [chemical binding]; other site 83332006666 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332006667 MMPL family; Region: MMPL; pfam03176 83332006668 MMPL family; Region: MMPL; pfam03176 83332006669 PE family; Region: PE; pfam00934 83332006670 DNA primase; Validated; Region: dnaG; PRK05667 83332006671 CHC2 zinc finger; Region: zf-CHC2; pfam01807 83332006672 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 83332006673 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 83332006674 active site 83332006675 metal binding site [ion binding]; metal-binding site 83332006676 interdomain interaction site; other site 83332006677 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 83332006678 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 83332006679 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 83332006680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332006681 Zn2+ binding site [ion binding]; other site 83332006682 Mg2+ binding site [ion binding]; other site 83332006683 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 83332006684 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 83332006685 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332006686 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332006687 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006688 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006689 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006690 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006691 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 83332006692 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332006693 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006694 PPE family; Region: PPE; pfam00823 83332006695 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332006696 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006697 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006698 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006699 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006700 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332006702 Transposase; Region: HTH_Tnp_1; cl17663 83332006703 putative transposase OrfB; Reviewed; Region: PHA02517 83332006704 HTH-like domain; Region: HTH_21; pfam13276 83332006705 Integrase core domain; Region: rve; pfam00665 83332006706 Integrase core domain; Region: rve_3; pfam13683 83332006707 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006708 PPE family; Region: PPE; pfam00823 83332006709 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006710 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006711 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006712 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006713 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006714 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006715 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006716 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332006717 glycyl-tRNA synthetase; Provisional; Region: PRK04173 83332006718 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 83332006719 dimer interface [polypeptide binding]; other site 83332006720 motif 1; other site 83332006721 active site 83332006722 motif 2; other site 83332006723 motif 3; other site 83332006724 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 83332006725 anticodon binding site; other site 83332006726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332006727 dimerization interface [polypeptide binding]; other site 83332006728 putative DNA binding site [nucleotide binding]; other site 83332006729 putative Zn2+ binding site [ion binding]; other site 83332006730 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 83332006731 metal binding site 2 [ion binding]; metal-binding site 83332006732 putative DNA binding helix; other site 83332006733 metal binding site 1 [ion binding]; metal-binding site 83332006734 dimer interface [polypeptide binding]; other site 83332006735 structural Zn2+ binding site [ion binding]; other site 83332006736 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 83332006737 active site 83332006738 dimer interface [polypeptide binding]; other site 83332006739 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 83332006740 Recombination protein O N terminal; Region: RecO_N; pfam11967 83332006741 Recombination protein O C terminal; Region: RecO_C; pfam02565 83332006742 amidase; Provisional; Region: PRK06061 83332006743 GTPase Era; Reviewed; Region: era; PRK00089 83332006744 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 83332006745 G1 box; other site 83332006746 GTP/Mg2+ binding site [chemical binding]; other site 83332006747 Switch I region; other site 83332006748 G2 box; other site 83332006749 Switch II region; other site 83332006750 G3 box; other site 83332006751 G4 box; other site 83332006752 G5 box; other site 83332006753 KH domain; Region: KH_2; pfam07650 83332006754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 83332006755 Domain of unknown function DUF21; Region: DUF21; pfam01595 83332006756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 83332006757 Transporter associated domain; Region: CorC_HlyC; smart01091 83332006758 metal-binding heat shock protein; Provisional; Region: PRK00016 83332006759 K homology RNA-binding domain; Region: KH; smart00322 83332006760 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 83332006761 PhoH-like protein; Region: PhoH; pfam02562 83332006762 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 83332006763 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 83332006764 PE family; Region: PE; pfam00934 83332006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 83332006766 chaperone protein DnaJ; Provisional; Region: PRK14278 83332006767 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 83332006768 HSP70 interaction site [polypeptide binding]; other site 83332006769 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 83332006770 Zn binding sites [ion binding]; other site 83332006771 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 83332006772 dimer interface [polypeptide binding]; other site 83332006773 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 83332006774 HrcA protein C terminal domain; Region: HrcA; pfam01628 83332006775 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332006776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 83332006777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332006778 Condensation domain; Region: Condensation; pfam00668 83332006779 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006780 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332006781 acyl-activating enzyme (AAE) consensus motif; other site 83332006782 AMP binding site [chemical binding]; other site 83332006783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006784 Condensation domain; Region: Condensation; cl19241 83332006785 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 83332006786 Condensation domain; Region: Condensation; cl19241 83332006787 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006788 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332006789 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 83332006790 acyl-activating enzyme (AAE) consensus motif; other site 83332006791 AMP binding site [chemical binding]; other site 83332006792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006793 Condensation domain; Region: Condensation; cl19241 83332006794 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 83332006795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332006796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006797 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332006798 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332006799 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332006800 NADP binding site [chemical binding]; other site 83332006801 active site 83332006802 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332006803 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332006804 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332006805 active site 83332006806 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 83332006807 Condensation domain; Region: Condensation; cl19241 83332006808 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332006809 Nonribosomal peptide synthase; Region: NRPS; pfam08415 83332006810 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 83332006811 acyl-activating enzyme (AAE) consensus motif; other site 83332006812 AMP binding site [chemical binding]; other site 83332006813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332006814 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 83332006815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332006816 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 83332006817 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 83332006818 acyl-activating enzyme (AAE) consensus motif; other site 83332006819 active site 83332006820 AMP binding site [chemical binding]; other site 83332006821 substrate binding site [chemical binding]; other site 83332006822 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332006823 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332006824 salicylate synthase MbtI; Reviewed; Region: PRK07912 83332006825 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332006826 Predicted permease [General function prediction only]; Region: COG3329 83332006827 coproporphyrinogen III oxidase; Validated; Region: PRK05628 83332006828 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 83332006829 HemN C-terminal domain; Region: HemN_C; pfam06969 83332006830 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332006831 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 83332006832 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332006833 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 83332006834 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 83332006835 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 83332006836 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 83332006837 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 83332006838 Active Sites [active] 83332006839 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 83332006840 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 83332006841 putative active site [active] 83332006842 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 83332006843 putative active site [active] 83332006844 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 83332006845 OPT oligopeptide transporter protein; Region: OPT; cl14607 83332006846 PE family; Region: PE; pfam00934 83332006847 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 83332006848 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 83332006849 Walker A/P-loop; other site 83332006850 ATP binding site [chemical binding]; other site 83332006851 Q-loop/lid; other site 83332006852 ABC transporter signature motif; other site 83332006853 Walker B; other site 83332006854 D-loop; other site 83332006855 H-loop/switch region; other site 83332006856 TOBE domain; Region: TOBE; pfam03459 83332006857 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 83332006858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006859 dimer interface [polypeptide binding]; other site 83332006860 conserved gate region; other site 83332006861 putative PBP binding loops; other site 83332006862 ABC-ATPase subunit interface; other site 83332006863 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 83332006864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332006865 dimer interface [polypeptide binding]; other site 83332006866 conserved gate region; other site 83332006867 putative PBP binding loops; other site 83332006868 ABC-ATPase subunit interface; other site 83332006869 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 83332006870 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 83332006871 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 83332006872 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332006873 GTP-binding protein LepA; Provisional; Region: PRK05433 83332006874 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 83332006875 G1 box; other site 83332006876 putative GEF interaction site [polypeptide binding]; other site 83332006877 GTP/Mg2+ binding site [chemical binding]; other site 83332006878 Switch I region; other site 83332006879 G2 box; other site 83332006880 G3 box; other site 83332006881 Switch II region; other site 83332006882 G4 box; other site 83332006883 G5 box; other site 83332006884 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 83332006885 Elongation Factor G, domain II; Region: EFG_II; pfam14492 83332006886 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 83332006887 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 83332006888 PemK-like protein; Region: PemK; pfam02452 83332006889 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 83332006890 FOG: CBS domain [General function prediction only]; Region: COG0517 83332006891 ribonuclease Z; Reviewed; Region: PRK00055 83332006892 PE family; Region: PE; pfam00934 83332006893 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332006894 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332006895 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332006896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 83332006897 Uncharacterized conserved protein [Function unknown]; Region: COG2308 83332006898 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 83332006899 hypothetical protein; Reviewed; Region: PRK07914 83332006900 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 83332006901 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 83332006902 Competence protein; Region: Competence; pfam03772 83332006903 comEA protein; Region: comE; TIGR01259 83332006904 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 83332006905 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 83332006906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332006907 Coenzyme A binding pocket [chemical binding]; other site 83332006908 Sterol carrier protein domain; Region: SCP2_2; pfam13530 83332006909 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 83332006910 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 83332006911 active site 83332006912 catalytic triad [active] 83332006913 oxyanion hole [active] 83332006914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332006915 catalytic core [active] 83332006916 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 83332006917 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 83332006918 active site 83332006919 (T/H)XGH motif; other site 83332006920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332006921 S-adenosylmethionine binding site [chemical binding]; other site 83332006922 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332006923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332006924 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332006925 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 83332006926 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 83332006927 metal ion-dependent adhesion site (MIDAS); other site 83332006928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 83332006929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332006930 Walker A motif; other site 83332006931 ATP binding site [chemical binding]; other site 83332006932 Walker B motif; other site 83332006933 arginine finger; other site 83332006934 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 83332006935 putative catalytic cysteine [active] 83332006936 Rv2427A, Pseudogene oxyR', inactivated by multiple mutations; identical to sequence in u16243 (see Deretic et al., 1995). 83332006937 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332006938 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 83332006939 dimer interface [polypeptide binding]; other site 83332006940 decamer (pentamer of dimers) interface [polypeptide binding]; other site 83332006941 catalytic triad [active] 83332006942 peroxidatic and resolving cysteines [active] 83332006943 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 83332006944 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 83332006945 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332006946 PPE family; Region: PPE; pfam00823 83332006947 PE family; Region: PE; pfam00934 83332006948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 83332006949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 83332006950 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332006951 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332006952 ligand binding site [chemical binding]; other site 83332006953 flexible hinge region; other site 83332006954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332006955 dimerization interface [polypeptide binding]; other site 83332006956 Heme NO binding associated; Region: HNOBA; pfam07701 83332006957 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 83332006958 cyclase homology domain; Region: CHD; cd07302 83332006959 nucleotidyl binding site; other site 83332006960 metal binding site [ion binding]; metal-binding site 83332006961 dimer interface [polypeptide binding]; other site 83332006962 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 83332006963 substrate binding site [chemical binding]; other site 83332006964 dimer interface [polypeptide binding]; other site 83332006965 ATP binding site [chemical binding]; other site 83332006966 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332006967 NAD synthetase; Reviewed; Region: nadE; PRK02628 83332006968 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 83332006969 multimer interface [polypeptide binding]; other site 83332006970 active site 83332006971 catalytic triad [active] 83332006972 protein interface 1 [polypeptide binding]; other site 83332006973 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 83332006974 homodimer interface [polypeptide binding]; other site 83332006975 NAD binding pocket [chemical binding]; other site 83332006976 ATP binding pocket [chemical binding]; other site 83332006977 Mg binding site [ion binding]; other site 83332006978 active-site loop [active] 83332006979 glutamate 5-kinase; Region: proB; TIGR01027 83332006980 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 83332006981 nucleotide binding site [chemical binding]; other site 83332006982 homotetrameric interface [polypeptide binding]; other site 83332006983 putative phosphate binding site [ion binding]; other site 83332006984 putative allosteric binding site; other site 83332006985 PUA domain; Region: PUA; pfam01472 83332006986 GTPase CgtA; Reviewed; Region: obgE; PRK12296 83332006987 GTP1/OBG; Region: GTP1_OBG; pfam01018 83332006988 Obg GTPase; Region: Obg; cd01898 83332006989 G1 box; other site 83332006990 GTP/Mg2+ binding site [chemical binding]; other site 83332006991 Switch I region; other site 83332006992 G2 box; other site 83332006993 G3 box; other site 83332006994 Switch II region; other site 83332006995 G4 box; other site 83332006996 G5 box; other site 83332006997 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 83332006998 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 83332006999 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 83332007000 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 83332007001 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 83332007002 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 83332007003 homodimer interface [polypeptide binding]; other site 83332007004 oligonucleotide binding site [chemical binding]; other site 83332007005 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 83332007006 Nucleoside diphosphate kinase; Region: NDK; pfam00334 83332007007 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 83332007008 active site 83332007009 multimer interface [polypeptide binding]; other site 83332007010 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 83332007011 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 83332007012 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332007013 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 83332007014 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 83332007015 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 83332007016 active site 83332007017 HIGH motif; other site 83332007018 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 83332007019 KMSKS motif; other site 83332007020 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 83332007021 tRNA binding surface [nucleotide binding]; other site 83332007022 anticodon binding site; other site 83332007023 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 83332007024 Uncharacterized conserved protein [Function unknown]; Region: COG3268 83332007025 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 83332007026 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 83332007027 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 83332007028 GTP binding site; other site 83332007029 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 83332007030 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 83332007031 TPP-binding site [chemical binding]; other site 83332007032 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 83332007033 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 83332007034 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 83332007035 dimer interface [polypeptide binding]; other site 83332007036 PYR/PP interface [polypeptide binding]; other site 83332007037 TPP binding site [chemical binding]; other site 83332007038 substrate binding site [chemical binding]; other site 83332007039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332007040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332007041 putative substrate translocation pore; other site 83332007042 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 83332007043 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 83332007044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007045 Walker A motif; other site 83332007046 ATP binding site [chemical binding]; other site 83332007047 Walker B motif; other site 83332007048 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 83332007049 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 83332007050 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 83332007051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332007052 putative substrate translocation pore; other site 83332007053 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 83332007054 oligomer interface [polypeptide binding]; other site 83332007055 active site residues [active] 83332007056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 83332007057 oligomer interface [polypeptide binding]; other site 83332007058 active site residues [active] 83332007059 trigger factor; Provisional; Region: tig; PRK01490 83332007060 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 83332007061 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 83332007062 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 83332007063 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332007064 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332007065 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 83332007066 putative DNA binding site [nucleotide binding]; other site 83332007067 catalytic residue [active] 83332007068 putative H2TH interface [polypeptide binding]; other site 83332007069 putative catalytic residues [active] 83332007070 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332007071 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332007072 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 83332007073 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 83332007074 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 83332007075 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 83332007076 Zn binding site [ion binding]; other site 83332007077 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 83332007078 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332007079 active site 83332007080 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 83332007081 apolar tunnel; other site 83332007082 heme binding site [chemical binding]; other site 83332007083 dimerization interface [polypeptide binding]; other site 83332007084 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 83332007085 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 83332007086 active site 83332007087 catalytic site [active] 83332007088 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 83332007089 active site 83332007090 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 83332007091 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 83332007092 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 83332007093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332007094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332007095 Walker A/P-loop; other site 83332007096 ATP binding site [chemical binding]; other site 83332007097 Q-loop/lid; other site 83332007098 ABC transporter signature motif; other site 83332007099 ABC transporter; Region: ABC_tran_2; pfam12848 83332007100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 83332007101 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 83332007102 dimer interface [polypeptide binding]; other site 83332007103 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 83332007104 ssDNA binding site [nucleotide binding]; other site 83332007105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 83332007106 putative transposase OrfB; Reviewed; Region: PHA02517 83332007107 HTH-like domain; Region: HTH_21; pfam13276 83332007108 Integrase core domain; Region: rve; pfam00665 83332007109 Integrase core domain; Region: rve_3; pfam13683 83332007110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332007111 Transposase; Region: HTH_Tnp_1; cl17663 83332007112 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 83332007113 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 83332007114 putative acyl-acceptor binding pocket; other site 83332007115 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 83332007116 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 83332007117 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332007118 putative acyl-acceptor binding pocket; other site 83332007119 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332007120 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332007121 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332007122 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 83332007123 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332007124 enoyl-CoA hydratase; Provisional; Region: PRK05870 83332007125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332007126 substrate binding site [chemical binding]; other site 83332007127 oxyanion hole (OAH) forming residues; other site 83332007128 trimer interface [polypeptide binding]; other site 83332007129 PE family; Region: PE; pfam00934 83332007130 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332007131 cyclase homology domain; Region: CHD; cd07302 83332007132 nucleotidyl binding site; other site 83332007133 metal binding site [ion binding]; metal-binding site 83332007134 dimer interface [polypeptide binding]; other site 83332007135 Predicted ATPase [General function prediction only]; Region: COG3903 83332007136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332007137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332007138 DNA binding residues [nucleotide binding] 83332007139 dimerization interface [polypeptide binding]; other site 83332007140 PE family; Region: PE; pfam00934 83332007141 TIGR00725 family protein; Region: TIGR00725 83332007142 thymidylate synthase; Provisional; Region: thyA; PRK00956 83332007143 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332007144 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 83332007145 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 83332007146 E3 interaction surface; other site 83332007147 lipoyl attachment site [posttranslational modification]; other site 83332007148 e3 binding domain; Region: E3_binding; pfam02817 83332007149 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 83332007150 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 83332007151 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 83332007152 alpha subunit interface [polypeptide binding]; other site 83332007153 TPP binding site [chemical binding]; other site 83332007154 heterodimer interface [polypeptide binding]; other site 83332007155 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332007156 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 83332007157 tetramer interface [polypeptide binding]; other site 83332007158 TPP-binding site [chemical binding]; other site 83332007159 heterodimer interface [polypeptide binding]; other site 83332007160 phosphorylation loop region [posttranslational modification] 83332007161 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 83332007162 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 83332007163 putative active site [active] 83332007164 putative catalytic site [active] 83332007165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007167 active site 83332007168 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332007169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332007170 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 83332007171 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332007172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332007173 carboxyltransferase (CT) interaction site; other site 83332007174 biotinylation site [posttranslational modification]; other site 83332007175 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 83332007176 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332007177 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332007178 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 83332007179 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 83332007180 AMP-binding domain protein; Validated; Region: PRK08315 83332007181 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 83332007182 acyl-activating enzyme (AAE) consensus motif; other site 83332007183 putative AMP binding site [chemical binding]; other site 83332007184 putative active site [active] 83332007185 putative CoA binding site [chemical binding]; other site 83332007186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332007187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332007188 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 83332007189 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332007190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332007191 NAD(P) binding site [chemical binding]; other site 83332007192 active site 83332007193 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 83332007194 Domain of unknown function DUF87; Region: DUF87; cl19135 83332007195 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 83332007196 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 83332007197 catalytic site [active] 83332007198 putative active site [active] 83332007199 putative substrate binding site [chemical binding]; other site 83332007200 dimer interface [polypeptide binding]; other site 83332007201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332007202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332007203 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 83332007204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332007205 non-specific DNA binding site [nucleotide binding]; other site 83332007206 salt bridge; other site 83332007207 sequence-specific DNA binding site [nucleotide binding]; other site 83332007208 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 83332007209 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 83332007210 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cd13430 83332007211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 83332007212 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 83332007213 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 83332007214 PE family; Region: PE; pfam00934 83332007215 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 83332007216 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 83332007217 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 83332007218 catalytic triad [active] 83332007219 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 83332007220 hypothetical protein; Provisional; Region: PRK08201 83332007221 active site 83332007222 metal binding site [ion binding]; metal-binding site 83332007223 dimer interface [polypeptide binding]; other site 83332007224 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 83332007225 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332007226 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 83332007227 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332007228 phosphate binding site [ion binding]; other site 83332007229 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 83332007230 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 83332007231 putative active site [active] 83332007232 putative catalytic site [active] 83332007233 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 83332007234 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 83332007235 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 83332007236 putative NAD(P) binding site [chemical binding]; other site 83332007237 active site 83332007238 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 83332007239 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 83332007240 active site 83332007241 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 83332007242 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 83332007243 putative active site [active] 83332007244 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 83332007245 Mrr N-terminal domain; Region: Mrr_N; pfam14338 83332007246 Restriction endonuclease; Region: Mrr_cat; pfam04471 83332007247 ERCC4 domain; Region: ERCC4; pfam02732 83332007248 Lsr2; Region: Lsr2; pfam11774 83332007249 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332007250 putative active site [active] 83332007251 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 83332007252 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332007253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332007254 catalytic residue [active] 83332007255 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 83332007256 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 83332007257 putative RNA binding site [nucleotide binding]; other site 83332007258 elongation factor P; Validated; Region: PRK00529 83332007259 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 83332007260 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 83332007261 RNA binding site [nucleotide binding]; other site 83332007262 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 83332007263 RNA binding site [nucleotide binding]; other site 83332007264 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 83332007265 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 83332007266 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 83332007267 active site 83332007268 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 83332007269 trimer interface [polypeptide binding]; other site 83332007270 active site 83332007271 dimer interface [polypeptide binding]; other site 83332007272 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 83332007273 active site 83332007274 dimer interface [polypeptide binding]; other site 83332007275 metal binding site [ion binding]; metal-binding site 83332007276 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 83332007277 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 83332007278 ADP binding site [chemical binding]; other site 83332007279 magnesium binding site [ion binding]; other site 83332007280 putative shikimate binding site; other site 83332007281 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 83332007282 Tetramer interface [polypeptide binding]; other site 83332007283 active site 83332007284 FMN-binding site [chemical binding]; other site 83332007285 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332007286 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 83332007287 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332007288 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332007289 putative active site [active] 83332007290 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007291 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 83332007292 oligomeric interface; other site 83332007293 putative active site [active] 83332007294 homodimer interface [polypeptide binding]; other site 83332007295 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 83332007296 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 83332007297 putative active site [active] 83332007298 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007299 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 83332007300 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 83332007301 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 83332007302 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 83332007303 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 83332007304 NAD(P) binding site [chemical binding]; other site 83332007305 shikimate binding site; other site 83332007306 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 83332007307 dimerization interface [polypeptide binding]; other site 83332007308 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 83332007309 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 83332007310 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 83332007311 motif 1; other site 83332007312 active site 83332007313 motif 2; other site 83332007314 motif 3; other site 83332007315 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 83332007316 DHHA1 domain; Region: DHHA1; pfam02272 83332007317 Uncharacterized conserved protein [Function unknown]; Region: COG0432 83332007318 recombination factor protein RarA; Reviewed; Region: PRK13342 83332007319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007320 Walker A motif; other site 83332007321 ATP binding site [chemical binding]; other site 83332007322 Walker B motif; other site 83332007323 arginine finger; other site 83332007324 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 83332007325 Predicted integral membrane protein [Function unknown]; Region: COG5473 83332007326 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 83332007327 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 83332007328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 83332007329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 83332007330 FtsX-like permease family; Region: FtsX; pfam02687 83332007331 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 83332007332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 83332007333 Walker A/P-loop; other site 83332007334 ATP binding site [chemical binding]; other site 83332007335 Q-loop/lid; other site 83332007336 ABC transporter signature motif; other site 83332007337 Walker B; other site 83332007338 D-loop; other site 83332007339 H-loop/switch region; other site 83332007340 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332007341 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332007342 ligand binding site [chemical binding]; other site 83332007343 flexible hinge region; other site 83332007344 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332007345 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332007346 ligand binding site [chemical binding]; other site 83332007347 flexible hinge region; other site 83332007348 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332007349 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 83332007350 active site 83332007351 nucleophile elbow; other site 83332007352 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332007353 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332007354 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 83332007355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 83332007356 Uncharacterized conserved protein [Function unknown]; Region: COG2308 83332007357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 83332007358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 83332007359 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 83332007360 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 83332007361 Transglutaminase/protease-like homologues; Region: TGc; smart00460 83332007362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 83332007363 Predicted membrane protein [Function unknown]; Region: COG4129 83332007364 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 83332007365 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 83332007366 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 83332007367 dimer interface [polypeptide binding]; other site 83332007368 anticodon binding site; other site 83332007369 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 83332007370 homodimer interface [polypeptide binding]; other site 83332007371 motif 1; other site 83332007372 active site 83332007373 motif 2; other site 83332007374 GAD domain; Region: GAD; pfam02938 83332007375 motif 3; other site 83332007376 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 83332007377 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 83332007378 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 83332007379 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332007380 putative hydrophobic ligand binding site [chemical binding]; other site 83332007381 protein interface [polypeptide binding]; other site 83332007382 gate; other site 83332007383 Predicted metalloprotease [General function prediction only]; Region: COG2321 83332007384 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332007385 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 83332007386 active site 83332007387 metal binding site [ion binding]; metal-binding site 83332007388 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 83332007389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332007390 FeS/SAM binding site; other site 83332007391 haloalkane dehalogenase; Provisional; Region: PRK03592 83332007392 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 83332007393 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 83332007394 dimer interface [polypeptide binding]; other site 83332007395 motif 1; other site 83332007396 active site 83332007397 motif 2; other site 83332007398 motif 3; other site 83332007399 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 83332007400 anticodon binding site; other site 83332007401 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 83332007402 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 83332007403 active site 83332007404 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 83332007405 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332007406 Zn2+ binding site [ion binding]; other site 83332007407 Mg2+ binding site [ion binding]; other site 83332007408 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 83332007409 synthetase active site [active] 83332007410 NTP binding site [chemical binding]; other site 83332007411 metal binding site [ion binding]; metal-binding site 83332007412 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 83332007413 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 83332007414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332007415 active site 83332007416 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 83332007417 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 83332007418 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 83332007419 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 83332007420 Protein export membrane protein; Region: SecD_SecF; pfam02355 83332007421 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 83332007422 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 83332007423 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 83332007424 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 83332007425 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332007426 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332007427 inhibitor-cofactor binding pocket; inhibition site 83332007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332007429 catalytic residue [active] 83332007430 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 83332007431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332007432 acyl-activating enzyme (AAE) consensus motif; other site 83332007433 AMP binding site [chemical binding]; other site 83332007434 active site 83332007435 CoA binding site [chemical binding]; other site 83332007436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332007437 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 83332007438 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 83332007439 putative NAD(P) binding site [chemical binding]; other site 83332007440 active site 83332007441 putative substrate binding site [chemical binding]; other site 83332007442 PE family; Region: PE; pfam00934 83332007443 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 83332007444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332007445 Walker A motif; other site 83332007446 ATP binding site [chemical binding]; other site 83332007447 Walker B motif; other site 83332007448 arginine finger; other site 83332007449 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 83332007450 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 83332007451 RuvA N terminal domain; Region: RuvA_N; pfam01330 83332007452 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 83332007453 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 83332007454 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 83332007455 active site 83332007456 putative DNA-binding cleft [nucleotide binding]; other site 83332007457 dimer interface [polypeptide binding]; other site 83332007458 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 83332007459 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332007460 putative active site [active] 83332007461 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 83332007462 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 83332007463 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 83332007464 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 83332007465 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 83332007466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007467 S-adenosylmethionine binding site [chemical binding]; other site 83332007468 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 83332007469 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332007470 hypothetical protein; Validated; Region: PRK00110 83332007471 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 83332007472 predicted active site [active] 83332007473 catalytic triad [active] 83332007474 acyl-CoA thioesterase II; Region: tesB; TIGR00189 83332007475 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 83332007476 active site 83332007477 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 83332007478 catalytic triad [active] 83332007479 dimer interface [polypeptide binding]; other site 83332007480 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 83332007481 active site 83332007482 multimer interface [polypeptide binding]; other site 83332007483 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 83332007484 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 83332007485 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 83332007486 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 83332007487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007488 PPE family; Region: PPE; pfam00823 83332007489 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332007490 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332007491 PE-PPE domain; Region: PE-PPE; pfam08237 83332007492 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 83332007493 nudix motif; other site 83332007494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332007495 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332007496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 83332007497 putative acyl-acceptor binding pocket; other site 83332007498 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332007499 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 83332007500 nucleotide binding site/active site [active] 83332007501 HIT family signature motif; other site 83332007502 catalytic residue [active] 83332007503 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 83332007504 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 83332007505 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 83332007506 active site 83332007507 dimer interface [polypeptide binding]; other site 83332007508 motif 1; other site 83332007509 motif 2; other site 83332007510 motif 3; other site 83332007511 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 83332007512 anticodon binding site; other site 83332007513 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332007514 phosphate binding site [ion binding]; other site 83332007515 PE family; Region: PE; pfam00934 83332007516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 83332007517 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332007518 Helix-turn-helix domain; Region: HTH_20; pfam12840 83332007519 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 83332007520 Predicted transcriptional regulator [Transcription]; Region: COG2345 83332007521 Helix-turn-helix domain; Region: HTH_20; pfam12840 83332007522 putative DNA binding site [nucleotide binding]; other site 83332007523 putative Zn2+ binding site [ion binding]; other site 83332007524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007525 S-adenosylmethionine binding site [chemical binding]; other site 83332007526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007527 Ligand Binding Site [chemical binding]; other site 83332007528 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007529 Ligand Binding Site [chemical binding]; other site 83332007530 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007531 Ligand Binding Site [chemical binding]; other site 83332007532 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332007533 Ligand Binding Site [chemical binding]; other site 83332007534 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 83332007535 Peptidase family M50; Region: Peptidase_M50; pfam02163 83332007536 active site 83332007537 putative substrate binding region [chemical binding]; other site 83332007538 FOG: CBS domain [General function prediction only]; Region: COG0517 83332007539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 83332007540 FOG: CBS domain [General function prediction only]; Region: COG0517 83332007541 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 83332007542 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332007543 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 83332007544 eRF1 domain 3; Region: eRF1_3; pfam03465 83332007545 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 83332007546 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 83332007547 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 83332007548 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 83332007549 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 83332007550 Fe binding site [ion binding]; other site 83332007551 PE family; Region: PE; pfam00934 83332007552 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 83332007553 P-loop motif; other site 83332007554 ATP binding site [chemical binding]; other site 83332007555 Chloramphenicol (Cm) binding site [chemical binding]; other site 83332007556 catalytic residue [active] 83332007557 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 83332007558 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332007559 anti sigma factor interaction site; other site 83332007560 regulatory phosphorylation site [posttranslational modification]; other site 83332007561 hypothetical protein; Provisional; Region: PRK02237 83332007562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007563 dimerization interface [polypeptide binding]; other site 83332007564 putative DNA binding site [nucleotide binding]; other site 83332007565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332007566 putative Zn2+ binding site [ion binding]; other site 83332007567 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 83332007568 putative metal binding site [ion binding]; other site 83332007569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007570 dimerization interface [polypeptide binding]; other site 83332007571 putative DNA binding site [nucleotide binding]; other site 83332007572 putative Zn2+ binding site [ion binding]; other site 83332007573 arsenical-resistance protein; Region: acr3; TIGR00832 83332007574 Low molecular weight phosphatase family; Region: LMWPc; cd00115 83332007575 active site 83332007576 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 83332007577 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332007578 active site 83332007579 DNA binding site [nucleotide binding] 83332007580 Int/Topo IB signature motif; other site 83332007581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332007582 Transposase; Region: HTH_Tnp_1; cl17663 83332007583 putative transposase OrfB; Reviewed; Region: PHA02517 83332007584 HTH-like domain; Region: HTH_21; pfam13276 83332007585 Integrase core domain; Region: rve; pfam00665 83332007586 Integrase core domain; Region: rve_3; pfam13683 83332007587 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 83332007588 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 83332007589 Phage head maturation protease [General function prediction only]; Region: COG3740 83332007590 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 83332007591 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 83332007592 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 83332007593 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332007594 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 83332007595 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 83332007596 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 83332007597 active site 83332007598 catalytic residues [active] 83332007599 DNA binding site [nucleotide binding] 83332007600 Int/Topo IB signature motif; other site 83332007601 Transposase, Mutator family; Region: Transposase_mut; cl19537 83332007602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332007603 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 83332007604 Clp amino terminal domain; Region: Clp_N; pfam02861 83332007605 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 83332007606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007607 Coenzyme A binding pocket [chemical binding]; other site 83332007608 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 83332007609 hypothetical protein; Provisional; Region: PRK14059 83332007610 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332007611 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332007612 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332007613 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 83332007614 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 83332007615 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332007616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007617 S-adenosylmethionine binding site [chemical binding]; other site 83332007618 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 83332007619 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 83332007620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332007621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332007622 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 83332007623 substrate binding site [chemical binding]; other site 83332007624 active site 83332007625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332007626 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 83332007627 substrate binding site [chemical binding]; other site 83332007628 oxyanion hole (OAH) forming residues; other site 83332007629 trimer interface [polypeptide binding]; other site 83332007630 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 83332007631 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 83332007632 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 83332007633 catalytic site [active] 83332007634 putative active site [active] 83332007635 putative substrate binding site [chemical binding]; other site 83332007636 Helicase and RNase D C-terminal; Region: HRDC; smart00341 83332007637 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 83332007638 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 83332007639 TPP-binding site; other site 83332007640 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332007641 PYR/PP interface [polypeptide binding]; other site 83332007642 dimer interface [polypeptide binding]; other site 83332007643 TPP binding site [chemical binding]; other site 83332007644 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332007645 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 83332007646 FOG: CBS domain [General function prediction only]; Region: COG0517 83332007647 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 83332007648 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 83332007649 transmembrane helices; other site 83332007650 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 83332007651 transmembrane helices; other site 83332007652 Citrate transporter; Region: CitMHS; pfam03600 83332007653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 83332007654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 83332007655 Walker A/P-loop; other site 83332007656 ATP binding site [chemical binding]; other site 83332007657 Q-loop/lid; other site 83332007658 ABC transporter signature motif; other site 83332007659 Walker B; other site 83332007660 D-loop; other site 83332007661 H-loop/switch region; other site 83332007662 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 83332007663 TRAM domain; Region: TRAM; cl01282 83332007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332007665 S-adenosylmethionine binding site [chemical binding]; other site 83332007666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332007667 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 83332007668 K+ potassium transporter; Region: K_trans; cl15781 83332007669 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 83332007670 TrkA-N domain; Region: TrkA_N; pfam02254 83332007671 TrkA-C domain; Region: TrkA_C; pfam02080 83332007672 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 83332007673 TrkA-N domain; Region: TrkA_N; pfam02254 83332007674 TrkA-C domain; Region: TrkA_C; pfam02080 83332007675 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 83332007676 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 83332007677 generic binding surface II; other site 83332007678 ssDNA binding site; other site 83332007679 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 83332007680 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 83332007681 trimer interface [polypeptide binding]; other site 83332007682 active site 83332007683 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 83332007684 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 83332007685 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332007686 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 83332007687 active site 83332007688 dimerization interface [polypeptide binding]; other site 83332007689 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 83332007690 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 83332007691 nucleotide binding site [chemical binding]; other site 83332007692 RNA polymerase sigma factor; Provisional; Region: PRK05901 83332007693 Merozoite surface antigen 2c; Region: MSA-2c; pfam12238 83332007694 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 83332007695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332007696 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332007697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332007698 DNA binding residues [nucleotide binding] 83332007699 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 83332007700 homotrimer interaction site [polypeptide binding]; other site 83332007701 putative active site [active] 83332007702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 83332007703 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 83332007704 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 83332007705 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 83332007706 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 83332007707 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 83332007708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332007709 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332007710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332007711 DNA binding residues [nucleotide binding] 83332007712 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 83332007713 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 83332007714 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 83332007715 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 83332007716 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 83332007717 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 83332007718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332007719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332007720 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 83332007721 PAC2 family; Region: PAC2; pfam09754 83332007722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332007723 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332007724 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 83332007725 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 83332007726 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 83332007727 heme-binding site [chemical binding]; other site 83332007728 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 83332007729 ATP cone domain; Region: ATP-cone; pfam03477 83332007730 LysM domain; Region: LysM; pfam01476 83332007731 LexA repressor; Validated; Region: PRK00215 83332007732 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 83332007733 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 83332007734 Catalytic site [active] 83332007735 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 83332007736 LGFP repeat; Region: LGFP; pfam08310 83332007737 LGFP repeat; Region: LGFP; pfam08310 83332007738 LGFP repeat; Region: LGFP; pfam08310 83332007739 LGFP repeat; Region: LGFP; pfam08310 83332007740 LGFP repeat; Region: LGFP; pfam08310 83332007741 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 83332007742 Integral membrane protein TerC family; Region: TerC; cl10468 83332007743 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007744 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007745 active site 83332007746 GTPases [General function prediction only]; Region: HflX; COG2262 83332007747 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 83332007748 HflX GTPase family; Region: HflX; cd01878 83332007749 G1 box; other site 83332007750 GTP/Mg2+ binding site [chemical binding]; other site 83332007751 Switch I region; other site 83332007752 G2 box; other site 83332007753 G3 box; other site 83332007754 Switch II region; other site 83332007755 G4 box; other site 83332007756 G5 box; other site 83332007757 diaminopimelate epimerase; Region: DapF; TIGR00652 83332007758 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 83332007759 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 83332007760 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 83332007761 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 83332007762 active site 83332007763 metal binding site [ion binding]; metal-binding site 83332007764 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007765 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007766 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 83332007767 Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499 83332007768 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 83332007769 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 83332007770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332007771 FeS/SAM binding site; other site 83332007772 TRAM domain; Region: TRAM; cl01282 83332007773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332007774 FeS/SAM binding site; other site 83332007775 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 83332007776 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 83332007777 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 83332007778 hexamer interface [polypeptide binding]; other site 83332007779 Walker A motif; other site 83332007780 ATP binding site [chemical binding]; other site 83332007781 Walker B motif; other site 83332007782 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 83332007783 protein-splicing catalytic site; other site 83332007784 thioester formation/cholesterol transfer; other site 83332007785 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 83332007786 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 83332007787 recA bacterial DNA recombination protein; Region: RecA; cl19152 83332007788 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 83332007789 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 83332007790 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332007791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 83332007792 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 83332007793 PE family; Region: PE; pfam00934 83332007794 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 83332007795 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 83332007796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332007797 non-specific DNA binding site [nucleotide binding]; other site 83332007798 salt bridge; other site 83332007799 sequence-specific DNA binding site [nucleotide binding]; other site 83332007800 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 83332007801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007802 Coenzyme A binding pocket [chemical binding]; other site 83332007803 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 83332007804 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 83332007805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332007806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 83332007807 Uncharacterized conserved protein [Function unknown]; Region: COG1359 83332007808 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 83332007809 classical (c) SDRs; Region: SDR_c; cd05233 83332007810 NAD(P) binding site [chemical binding]; other site 83332007811 active site 83332007812 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332007813 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 83332007814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332007815 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 83332007816 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 83332007817 dimer interface [polypeptide binding]; other site 83332007818 active site 83332007819 catalytic residue [active] 83332007820 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 83332007821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 83332007822 HsdM N-terminal domain; Region: HsdM_N; pfam12161 83332007823 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 83332007824 Methyltransferase domain; Region: Methyltransf_26; pfam13659 83332007825 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 83332007826 putative active site [active] 83332007827 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 83332007828 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 83332007829 putative active site [active] 83332007830 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 83332007831 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 83332007832 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 83332007833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 83332007834 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 83332007835 folate binding site [chemical binding]; other site 83332007836 NADP+ binding site [chemical binding]; other site 83332007837 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 83332007838 dimerization interface [polypeptide binding]; other site 83332007839 active site 83332007840 Dienelactone hydrolase family; Region: DLH; pfam01738 83332007841 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 83332007842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 83332007843 classical (c) SDRs; Region: SDR_c; cd05233 83332007844 NAD(P) binding site [chemical binding]; other site 83332007845 active site 83332007846 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007847 PPE family; Region: PPE; pfam00823 83332007848 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332007849 PE family; Region: PE; pfam00934 83332007850 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332007851 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332007852 PPE family; Region: PPE; pfam00823 83332007853 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332007854 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 83332007855 dihydrodipicolinate reductase; Provisional; Region: PRK00048 83332007856 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 83332007857 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 83332007858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332007859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332007860 Coenzyme A binding pocket [chemical binding]; other site 83332007861 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332007862 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 83332007863 FMN-binding pocket [chemical binding]; other site 83332007864 flavin binding motif; other site 83332007865 phosphate binding motif [ion binding]; other site 83332007866 beta-alpha-beta structure motif; other site 83332007867 NAD binding pocket [chemical binding]; other site 83332007868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332007869 catalytic loop [active] 83332007870 iron binding site [ion binding]; other site 83332007871 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 83332007872 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 83332007873 hydrophobic ligand binding site; other site 83332007874 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 83332007875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007876 putative DNA binding site [nucleotide binding]; other site 83332007877 putative Zn2+ binding site [ion binding]; other site 83332007878 AsnC family; Region: AsnC_trans_reg; pfam01037 83332007879 alanine dehydrogenase; Region: alaDH; TIGR00518 83332007880 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 83332007881 hexamer interface [polypeptide binding]; other site 83332007882 ligand binding site [chemical binding]; other site 83332007883 putative active site [active] 83332007884 NAD(P) binding site [chemical binding]; other site 83332007885 Nitronate monooxygenase; Region: NMO; pfam03060 83332007886 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332007887 FMN binding site [chemical binding]; other site 83332007888 substrate binding site [chemical binding]; other site 83332007889 putative catalytic residue [active] 83332007890 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 83332007891 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 83332007892 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 83332007893 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 83332007894 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 83332007895 oligomer interface [polypeptide binding]; other site 83332007896 RNA binding site [nucleotide binding]; other site 83332007897 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 83332007898 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 83332007899 RNase E interface [polypeptide binding]; other site 83332007900 trimer interface [polypeptide binding]; other site 83332007901 active site 83332007902 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 83332007903 putative nucleic acid binding region [nucleotide binding]; other site 83332007904 G-X-X-G motif; other site 83332007905 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 83332007906 RNA binding site [nucleotide binding]; other site 83332007907 domain interface; other site 83332007908 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 83332007909 16S/18S rRNA binding site [nucleotide binding]; other site 83332007910 S13e-L30e interaction site [polypeptide binding]; other site 83332007911 25S rRNA binding site [nucleotide binding]; other site 83332007912 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 83332007913 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 83332007914 active site 83332007915 Riboflavin kinase; Region: Flavokinase; pfam01687 83332007916 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332007917 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 83332007918 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 83332007919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332007920 putative DNA binding site [nucleotide binding]; other site 83332007921 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 83332007922 FeoA domain; Region: FeoA; pfam04023 83332007923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332007924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332007925 active site 83332007926 lipid-transfer protein; Provisional; Region: PRK08256 83332007927 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332007928 active site 83332007929 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332007930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332007931 Probable transposase; Region: OrfB_IS605; pfam01385 83332007932 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 83332007933 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332007934 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332007935 catalytic residues [active] 83332007936 catalytic nucleophile [active] 83332007937 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 83332007938 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 83332007939 RNA binding site [nucleotide binding]; other site 83332007940 active site 83332007941 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 83332007942 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 83332007943 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 83332007944 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 83332007945 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 83332007946 active site 83332007947 metal binding site [ion binding]; metal-binding site 83332007948 Uncharacterized conserved protein [Function unknown]; Region: COG4717 83332007949 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 83332007950 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 83332007951 Predicted acyl esterases [General function prediction only]; Region: COG2936 83332007952 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 83332007953 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 83332007954 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332007955 Uncharacterized conserved protein [Function unknown]; Region: COG5586 83332007956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 83332007957 Integrase core domain; Region: rve; pfam00665 83332007958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332007959 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332007960 Helix-turn-helix domain; Region: HTH_28; pfam13518 83332007961 Winged helix-turn helix; Region: HTH_29; pfam13551 83332007962 Homeodomain-like domain; Region: HTH_32; pfam13565 83332007963 Integrase core domain; Region: rve; pfam00665 83332007964 Integrase core domain; Region: rve_3; pfam13683 83332007965 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 83332007966 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 83332007967 AAA domain; Region: AAA_22; pfam13401 83332007968 putative transposase OrfB; Reviewed; Region: PHA02517 83332007969 HTH-like domain; Region: HTH_21; pfam13276 83332007970 Integrase core domain; Region: rve; pfam00665 83332007971 Integrase core domain; Region: rve_3; pfam13683 83332007972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332007973 Transposase; Region: HTH_Tnp_1; cl17663 83332007974 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 83332007975 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 83332007976 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 83332007977 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 83332007978 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 83332007979 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 83332007980 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 83332007981 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 83332007982 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 83332007983 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 83332007984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 83332007985 Uncharacterized conserved protein [Function unknown]; Region: COG2253 83332007986 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 83332007987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 83332007988 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 83332007989 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 83332007990 putative active site [active] 83332007991 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332007992 enoyl-CoA hydratase; Provisional; Region: PRK06190 83332007993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332007994 substrate binding site [chemical binding]; other site 83332007995 oxyanion hole (OAH) forming residues; other site 83332007996 trimer interface [polypeptide binding]; other site 83332007997 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 83332007998 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 83332007999 Walker A/P-loop; other site 83332008000 ATP binding site [chemical binding]; other site 83332008001 Q-loop/lid; other site 83332008002 ABC transporter signature motif; other site 83332008003 Walker B; other site 83332008004 D-loop; other site 83332008005 H-loop/switch region; other site 83332008006 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 83332008007 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 83332008008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 83332008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332008010 dimer interface [polypeptide binding]; other site 83332008011 conserved gate region; other site 83332008012 putative PBP binding loops; other site 83332008013 ABC-ATPase subunit interface; other site 83332008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332008015 dimer interface [polypeptide binding]; other site 83332008016 conserved gate region; other site 83332008017 putative PBP binding loops; other site 83332008018 ABC-ATPase subunit interface; other site 83332008019 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 83332008020 putative efflux protein, MATE family; Region: matE; TIGR00797 83332008021 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 83332008022 DHH family; Region: DHH; pfam01368 83332008023 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 83332008024 translation initiation factor IF-2; Validated; Region: infB; PRK05306 83332008025 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 83332008026 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 83332008027 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 83332008028 G1 box; other site 83332008029 putative GEF interaction site [polypeptide binding]; other site 83332008030 GTP/Mg2+ binding site [chemical binding]; other site 83332008031 Switch I region; other site 83332008032 G2 box; other site 83332008033 G3 box; other site 83332008034 Switch II region; other site 83332008035 G4 box; other site 83332008036 G5 box; other site 83332008037 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 83332008038 Translation-initiation factor 2; Region: IF-2; pfam11987 83332008039 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 83332008040 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 83332008041 putative RNA binding cleft [nucleotide binding]; other site 83332008042 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 83332008043 NusA N-terminal domain; Region: NusA_N; pfam08529 83332008044 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 83332008045 RNA binding site [nucleotide binding]; other site 83332008046 homodimer interface [polypeptide binding]; other site 83332008047 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 83332008048 G-X-X-G motif; other site 83332008049 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 83332008050 G-X-X-G motif; other site 83332008051 Sm and related proteins; Region: Sm_like; cl00259 83332008052 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 83332008053 putative oligomer interface [polypeptide binding]; other site 83332008054 putative RNA binding site [nucleotide binding]; other site 83332008055 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 83332008056 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 83332008057 dinuclear metal binding motif [ion binding]; other site 83332008058 prolyl-tRNA synthetase; Provisional; Region: PRK09194 83332008059 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 83332008060 dimer interface [polypeptide binding]; other site 83332008061 motif 1; other site 83332008062 active site 83332008063 motif 2; other site 83332008064 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332008065 putative deacylase active site [active] 83332008066 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 83332008067 anticodon binding site; other site 83332008068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332008069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332008070 putative substrate translocation pore; other site 83332008071 siroheme synthase; Provisional; Region: cysG; PRK10637 83332008072 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 83332008073 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 83332008074 active site 83332008075 SAM binding site [chemical binding]; other site 83332008076 homodimer interface [polypeptide binding]; other site 83332008077 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 83332008078 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332008079 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 83332008080 catalytic triad [active] 83332008081 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 83332008082 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 83332008083 homodimer interface [polypeptide binding]; other site 83332008084 Walker A motif; other site 83332008085 ATP binding site [chemical binding]; other site 83332008086 hydroxycobalamin binding site [chemical binding]; other site 83332008087 Walker B motif; other site 83332008088 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 83332008089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332008090 Walker A motif; other site 83332008091 ATP binding site [chemical binding]; other site 83332008092 Walker B motif; other site 83332008093 arginine finger; other site 83332008094 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 83332008095 metal ion-dependent adhesion site (MIDAS); other site 83332008096 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 83332008097 Predicted dehydrogenase [General function prediction only]; Region: COG0579 83332008098 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 83332008099 PE family; Region: PE; pfam00934 83332008100 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 83332008101 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332008102 mycothione reductase; Reviewed; Region: PRK07846 83332008103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332008104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332008105 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 83332008106 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 83332008107 short chain dehydrogenase; Provisional; Region: PRK06057 83332008108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008109 NAD(P) binding site [chemical binding]; other site 83332008110 active site 83332008111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 83332008112 NAD(P) binding site [chemical binding]; other site 83332008113 catalytic residues [active] 83332008114 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 83332008115 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 83332008116 catalytic triad [active] 83332008117 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 83332008118 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 83332008119 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 83332008120 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 83332008121 active site 83332008122 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 83332008123 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332008124 putative active site [active] 83332008125 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 83332008126 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 83332008127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 83332008128 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332008129 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 83332008130 Predicted acetyltransferase [General function prediction only]; Region: COG3393 83332008131 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 83332008132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332008133 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 83332008134 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 83332008135 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 83332008136 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 83332008137 active site 83332008138 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 83332008139 protein binding site [polypeptide binding]; other site 83332008140 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 83332008141 putative substrate binding region [chemical binding]; other site 83332008142 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 83332008143 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 83332008144 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 83332008145 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 83332008146 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 83332008147 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332008148 putative active site [active] 83332008149 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 83332008150 Fasciclin domain; Region: Fasciclin; pfam02469 83332008151 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332008152 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 83332008153 catalytic residues [active] 83332008154 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 83332008155 Fasciclin domain; Region: Fasciclin; pfam02469 83332008156 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 83332008157 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 83332008158 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 83332008159 catalytic residues [active] 83332008160 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 83332008161 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 83332008162 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 83332008163 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 83332008164 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 83332008165 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 83332008166 hinge region; other site 83332008167 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 83332008168 putative nucleotide binding site [chemical binding]; other site 83332008169 uridine monophosphate binding site [chemical binding]; other site 83332008170 homohexameric interface [polypeptide binding]; other site 83332008171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332008172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332008173 DNA binding site [nucleotide binding] 83332008174 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332008175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332008176 Probable transposase; Region: OrfB_IS605; pfam01385 83332008177 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 83332008178 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332008179 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 83332008180 catalytic residues [active] 83332008181 catalytic nucleophile [active] 83332008182 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 83332008183 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332008184 amidase; Provisional; Region: PRK07869 83332008185 elongation factor Ts; Provisional; Region: tsf; PRK09377 83332008186 UBA/TS-N domain; Region: UBA; pfam00627 83332008187 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 83332008188 rRNA interaction site [nucleotide binding]; other site 83332008189 S8 interaction site; other site 83332008190 putative laminin-1 binding site; other site 83332008191 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332008192 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332008193 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008194 PPE family; Region: PPE; pfam00823 83332008195 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332008196 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 83332008197 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 83332008198 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332008199 active site 83332008200 DNA binding site [nucleotide binding] 83332008201 Int/Topo IB signature motif; other site 83332008202 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 83332008203 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 83332008204 FAD binding pocket [chemical binding]; other site 83332008205 FAD binding motif [chemical binding]; other site 83332008206 phosphate binding motif [ion binding]; other site 83332008207 NAD binding pocket [chemical binding]; other site 83332008208 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 83332008209 DNA protecting protein DprA; Region: dprA; TIGR00732 83332008210 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 83332008211 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 83332008212 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 83332008213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 83332008214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332008215 Walker A motif; other site 83332008216 ATP binding site [chemical binding]; other site 83332008217 Walker B motif; other site 83332008218 arginine finger; other site 83332008219 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 83332008220 hypothetical protein; Reviewed; Region: PRK12497 83332008221 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 83332008222 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 83332008223 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 83332008224 putative molybdopterin cofactor binding site [chemical binding]; other site 83332008225 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 83332008226 putative molybdopterin cofactor binding site; other site 83332008227 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 83332008228 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 83332008229 RNA/DNA hybrid binding site [nucleotide binding]; other site 83332008230 active site 83332008231 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 83332008232 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 83332008233 Catalytic site [active] 83332008234 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 83332008235 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 83332008236 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 83332008237 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 83332008238 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 83332008239 RimM N-terminal domain; Region: RimM; pfam01782 83332008240 hypothetical protein; Provisional; Region: PRK02821 83332008241 G-X-X-G motif; other site 83332008242 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 83332008243 ribosomal protein S16; Region: S16; TIGR00002 83332008244 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 83332008245 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 83332008246 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 83332008247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008249 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 83332008250 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 83332008251 active site 83332008252 putative substrate binding pocket [chemical binding]; other site 83332008253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332008254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332008255 active site 83332008256 ATP binding site [chemical binding]; other site 83332008257 substrate binding site [chemical binding]; other site 83332008258 activation loop (A-loop); other site 83332008259 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 83332008260 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 83332008261 active site 83332008262 signal recognition particle protein; Provisional; Region: PRK10867 83332008263 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 83332008264 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 83332008265 P loop; other site 83332008266 GTP binding site [chemical binding]; other site 83332008267 Signal peptide binding domain; Region: SRP_SPB; pfam02978 83332008268 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 83332008269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332008270 ATP binding site [chemical binding]; other site 83332008271 putative Mg++ binding site [ion binding]; other site 83332008272 PII uridylyl-transferase; Provisional; Region: PRK03381 83332008273 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 83332008274 metal binding triad; other site 83332008275 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 83332008276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332008277 Zn2+ binding site [ion binding]; other site 83332008278 Mg2+ binding site [ion binding]; other site 83332008279 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 83332008280 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 83332008281 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 83332008282 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 83332008283 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 83332008284 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 83332008285 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 83332008286 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 83332008287 Walker A/P-loop; other site 83332008288 ATP binding site [chemical binding]; other site 83332008289 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 83332008290 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 83332008291 ABC transporter signature motif; other site 83332008292 Walker B; other site 83332008293 D-loop; other site 83332008294 H-loop/switch region; other site 83332008295 acylphosphatase; Provisional; Region: PRK14422 83332008296 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 83332008297 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 83332008298 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 83332008299 DNA binding site [nucleotide binding] 83332008300 catalytic residue [active] 83332008301 H2TH interface [polypeptide binding]; other site 83332008302 putative catalytic residues [active] 83332008303 turnover-facilitating residue; other site 83332008304 intercalation triad [nucleotide binding]; other site 83332008305 8OG recognition residue [nucleotide binding]; other site 83332008306 putative reading head residues; other site 83332008307 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332008308 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 83332008309 ribonuclease III; Reviewed; Region: rnc; PRK00102 83332008310 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 83332008311 dimerization interface [polypeptide binding]; other site 83332008312 active site 83332008313 metal binding site [ion binding]; metal-binding site 83332008314 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 83332008315 dsRNA binding site [nucleotide binding]; other site 83332008316 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 83332008317 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 83332008318 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 83332008319 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 83332008320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332008321 acyl-CoA synthetase; Validated; Region: PRK05850 83332008322 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008323 acyl-activating enzyme (AAE) consensus motif; other site 83332008324 active site 83332008325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332008326 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008327 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008328 active site 83332008329 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008330 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332008331 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332008332 NADP binding site [chemical binding]; other site 83332008333 short chain dehydrogenase; Region: adh_short; pfam00106 83332008334 active site 83332008335 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008336 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008337 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008338 active site 83332008339 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008340 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 83332008341 short chain dehydrogenase; Region: adh_short; pfam00106 83332008342 NADP binding site [chemical binding]; other site 83332008343 active site 83332008344 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008345 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008346 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008347 active site 83332008348 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008349 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332008350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008351 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008352 Enoylreductase; Region: PKS_ER; smart00829 83332008353 NAD(P) binding site [chemical binding]; other site 83332008354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008355 short chain dehydrogenase; Region: adh_short; pfam00106 83332008356 NAD(P) binding site [chemical binding]; other site 83332008357 active site 83332008358 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008359 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008361 active site 83332008362 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008363 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332008364 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332008365 putative NADP binding site [chemical binding]; other site 83332008366 short chain dehydrogenase; Region: adh_short; pfam00106 83332008367 active site 83332008368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008369 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008370 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008371 active site 83332008372 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332008374 Condensation domain; Region: Condensation; cl19241 83332008375 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 83332008376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008377 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 83332008378 Walker A/P-loop; other site 83332008379 ATP binding site [chemical binding]; other site 83332008380 Q-loop/lid; other site 83332008381 ABC transporter signature motif; other site 83332008382 Walker B; other site 83332008383 D-loop; other site 83332008384 H-loop/switch region; other site 83332008385 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332008386 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332008387 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 83332008388 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 83332008389 acyltransferase PapA5; Provisional; Region: PRK09294 83332008390 Condensation domain; Region: Condensation; cl19241 83332008391 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008392 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008393 active site 83332008394 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332008395 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332008396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008397 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008398 Enoylreductase; Region: PKS_ER; smart00829 83332008399 NAD(P) binding site [chemical binding]; other site 83332008400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008401 NAD(P) binding site [chemical binding]; other site 83332008402 short chain dehydrogenase; Region: adh_short; pfam00106 83332008403 active site 83332008404 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008405 acyl-CoA synthetase; Validated; Region: PRK05850 83332008406 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008407 acyl-activating enzyme (AAE) consensus motif; other site 83332008408 active site 83332008409 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332008410 MMPL family; Region: MMPL; pfam03176 83332008411 MMPL family; Region: MMPL; cl14618 83332008412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332008413 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 83332008414 DNA-binding interface [nucleotide binding]; DNA binding site 83332008415 Integrase core domain; Region: rve; pfam00665 83332008416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 83332008418 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 83332008419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332008420 ATP binding site [chemical binding]; other site 83332008421 Walker A motif; other site 83332008422 Walker B motif; other site 83332008423 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 83332008424 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332008425 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332008426 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332008427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008428 Enoylreductase; Region: PKS_ER; smart00829 83332008429 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332008430 NAD(P) binding site [chemical binding]; other site 83332008431 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 83332008432 short chain dehydrogenase; Region: adh_short; pfam00106 83332008433 putative NADP binding site [chemical binding]; other site 83332008434 active site 83332008435 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008436 Erythronolide synthase docking; Region: Docking; pfam08990 83332008437 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332008438 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 83332008439 active site 83332008440 acyl-CoA synthetase; Validated; Region: PRK06060 83332008441 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 83332008442 dimer interface [polypeptide binding]; other site 83332008443 acyl-activating enzyme (AAE) consensus motif; other site 83332008444 putative active site [active] 83332008445 putative AMP binding site [chemical binding]; other site 83332008446 putative CoA binding site [chemical binding]; other site 83332008447 chemical substrate binding site [chemical binding]; other site 83332008448 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332008449 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 83332008450 acyl-CoA synthetase; Validated; Region: PRK05850 83332008451 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332008452 acyl-activating enzyme (AAE) consensus motif; other site 83332008453 active site 83332008454 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332008455 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332008456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008457 S-adenosylmethionine binding site [chemical binding]; other site 83332008458 Uncharacterized conserved protein [Function unknown]; Region: COG3268 83332008459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008460 S-adenosylmethionine binding site [chemical binding]; other site 83332008461 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332008462 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 83332008463 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 83332008464 metal-binding site 83332008465 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332008466 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332008467 active site 83332008468 TDP-binding site; other site 83332008469 acceptor substrate-binding pocket; other site 83332008470 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 83332008471 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332008472 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 83332008473 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 83332008474 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 83332008475 active site 83332008476 TDP-binding site; other site 83332008477 acceptor substrate-binding pocket; other site 83332008478 Predicted permease; Region: DUF318; pfam03773 83332008479 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 83332008480 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 83332008481 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 83332008482 putative active site [active] 83332008483 putative substrate binding site [chemical binding]; other site 83332008484 putative cosubstrate binding site; other site 83332008485 catalytic site [active] 83332008486 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 83332008487 active site 83332008488 (T/H)XGH motif; other site 83332008489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008490 S-adenosylmethionine binding site [chemical binding]; other site 83332008491 pyruvate carboxylase; Reviewed; Region: PRK12999 83332008492 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332008493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332008494 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332008495 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 83332008496 active site 83332008497 catalytic residues [active] 83332008498 metal binding site [ion binding]; metal-binding site 83332008499 homodimer binding site [polypeptide binding]; other site 83332008500 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 83332008501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332008502 carboxyltransferase (CT) interaction site; other site 83332008503 biotinylation site [posttranslational modification]; other site 83332008504 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 83332008505 putative active site [active] 83332008506 redox center [active] 83332008507 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 83332008508 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 83332008509 catalytic residues [active] 83332008510 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332008511 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332008512 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 83332008513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 83332008514 active site 83332008515 catalytic tetrad [active] 83332008516 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 83332008517 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 83332008518 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 83332008519 generic binding surface II; other site 83332008520 ssDNA binding site; other site 83332008521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332008522 ATP binding site [chemical binding]; other site 83332008523 putative Mg++ binding site [ion binding]; other site 83332008524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332008525 nucleotide binding region [chemical binding]; other site 83332008526 ATP-binding site [chemical binding]; other site 83332008527 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 83332008528 DAK2 domain; Region: Dak2; cl03685 83332008529 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 83332008530 DAK2 domain; Region: Dak2; cl03685 83332008531 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 83332008532 ligand binding site [chemical binding]; other site 83332008533 active site 83332008534 UGI interface [polypeptide binding]; other site 83332008535 catalytic site [active] 83332008536 thiamine monophosphate kinase; Provisional; Region: PRK05731 83332008537 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 83332008538 ATP binding site [chemical binding]; other site 83332008539 dimerization interface [polypeptide binding]; other site 83332008540 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332008541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332008542 Probable transposase; Region: OrfB_IS605; pfam01385 83332008543 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 83332008544 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332008545 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 83332008546 catalytic residues [active] 83332008547 catalytic nucleophile [active] 83332008548 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 83332008549 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 83332008550 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 83332008551 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 83332008552 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 83332008553 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 83332008554 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 83332008555 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 83332008556 polyphosphate kinase; Provisional; Region: PRK05443 83332008557 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 83332008558 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 83332008559 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 83332008560 putative domain interface [polypeptide binding]; other site 83332008561 putative active site [active] 83332008562 catalytic site [active] 83332008563 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 83332008564 putative active site [active] 83332008565 catalytic site [active] 83332008566 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 83332008567 active site 83332008568 Ap6A binding site [chemical binding]; other site 83332008569 nudix motif; other site 83332008570 metal binding site [ion binding]; metal-binding site 83332008571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332008572 catalytic core [active] 83332008573 histone-like DNA-binding protein HU; Region: HU; cd13831 83332008574 dimer interface [polypeptide binding]; other site 83332008575 DNA binding site [nucleotide binding] 83332008576 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 83332008577 substrate binding site [chemical binding]; other site 83332008578 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 83332008579 substrate binding site [chemical binding]; other site 83332008580 ligand binding site [chemical binding]; other site 83332008581 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 83332008582 Transcriptional regulator [Transcription]; Region: IclR; COG1414 83332008583 Bacterial transcriptional regulator; Region: IclR; pfam01614 83332008584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008585 S-adenosylmethionine binding site [chemical binding]; other site 83332008586 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 83332008587 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 83332008588 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 83332008589 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 83332008590 active site 83332008591 HIGH motif; other site 83332008592 KMSKS motif; other site 83332008593 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 83332008594 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 83332008595 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 83332008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332008597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332008598 putative substrate translocation pore; other site 83332008599 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 83332008600 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 83332008601 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 83332008602 ligand binding site [chemical binding]; other site 83332008603 NAD binding site [chemical binding]; other site 83332008604 dimerization interface [polypeptide binding]; other site 83332008605 catalytic site [active] 83332008606 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 83332008607 putative L-serine binding site [chemical binding]; other site 83332008608 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332008609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332008610 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 83332008611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332008612 phosphorylation site [posttranslational modification] 83332008613 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332008614 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 83332008615 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 83332008616 ketol-acid reductoisomerase; Provisional; Region: PRK05479 83332008617 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 83332008618 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 83332008619 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 83332008620 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 83332008621 putative valine binding site [chemical binding]; other site 83332008622 dimer interface [polypeptide binding]; other site 83332008623 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 83332008624 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 83332008625 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332008626 PYR/PP interface [polypeptide binding]; other site 83332008627 dimer interface [polypeptide binding]; other site 83332008628 TPP binding site [chemical binding]; other site 83332008629 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332008630 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 83332008631 TPP-binding site [chemical binding]; other site 83332008632 dimer interface [polypeptide binding]; other site 83332008633 Bacterial PH domain; Region: bPH_6; pfam10756 83332008634 Predicted membrane protein [Function unknown]; Region: COG2259 83332008635 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 83332008636 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 83332008637 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 83332008638 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 83332008639 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 83332008640 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 83332008641 GatB domain; Region: GatB_Yqey; pfam02637 83332008642 6-phosphofructokinase; Provisional; Region: PRK03202 83332008643 active site 83332008644 ADP/pyrophosphate binding site [chemical binding]; other site 83332008645 dimerization interface [polypeptide binding]; other site 83332008646 allosteric effector site; other site 83332008647 fructose-1,6-bisphosphate binding site; other site 83332008648 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 83332008649 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 83332008650 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 83332008651 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 83332008652 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 83332008653 nucleotide binding pocket [chemical binding]; other site 83332008654 K-X-D-G motif; other site 83332008655 catalytic site [active] 83332008656 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 83332008657 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 83332008658 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 83332008659 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 83332008660 Dimer interface [polypeptide binding]; other site 83332008661 Cobalamin-independent synthase, Catalytic domain; Region: Meth_synt_2; pfam01717 83332008662 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332008663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332008664 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008665 PPE family; Region: PPE; pfam00823 83332008666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332008667 Rv3021c, (MTV012.35c), len: 358 aa. PPE47, Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent. Very similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 1714, E(): 6.6e-770, (78.3% identity in 355 aa overlap) and AAK47430|MT3101 (strongly in the N-terminal part) (310 aa),FASTA scores: opt: 897, E(): 4.5e-37, (66.95% identity in 227 aa overlap). 83332008668 Rv3022c, (MTV012.36c), len: 81 aa. PPE48, Member of M. tuberculosis PPE family with frameshift due to missing bp in codon 82. The ORF continues in downstream MTV012.35c. The sequence has been checked and no errors were detected. Identical to neigbouring ORF O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt: 526, E(): 6.2e-26, (100.0% identity in 81 aa overlap); and O69706|Rv739c|MTV025.087c (77 aa),FASTA scores: opt: 392, E(): 3.4e-18, (72.7% identity in 77 aa overlap). 83332008669 PE family; Region: PE; pfam00934 83332008670 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332008671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332008672 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 83332008673 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 83332008674 Ligand Binding Site [chemical binding]; other site 83332008675 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 83332008676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332008677 catalytic residue [active] 83332008678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332008679 putative acyl-acceptor binding pocket; other site 83332008680 Putative hemolysin [General function prediction only]; Region: COG3176 83332008681 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 83332008682 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 83332008683 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 83332008684 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 83332008685 Ligand binding site [chemical binding]; other site 83332008686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008687 S-adenosylmethionine binding site [chemical binding]; other site 83332008688 Uncharacterized conserved protein [Function unknown]; Region: COG1543 83332008689 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 83332008690 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 83332008691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 83332008692 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 83332008693 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332008694 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 83332008695 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 83332008696 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 83332008697 trimer interface [polypeptide binding]; other site 83332008698 active site 83332008699 substrate binding site [chemical binding]; other site 83332008700 CoA binding site [chemical binding]; other site 83332008701 FOG: WD40-like repeat [Function unknown]; Region: COG1520 83332008702 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 83332008703 active site 83332008704 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 83332008705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332008706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008707 S-adenosylmethionine binding site [chemical binding]; other site 83332008708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332008709 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 83332008710 substrate binding site [chemical binding]; other site 83332008711 oxyanion hole (OAH) forming residues; other site 83332008712 trimer interface [polypeptide binding]; other site 83332008713 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 83332008714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008715 Walker A/P-loop; other site 83332008716 ATP binding site [chemical binding]; other site 83332008717 Q-loop/lid; other site 83332008718 ABC transporter signature motif; other site 83332008719 Walker B; other site 83332008720 D-loop; other site 83332008721 H-loop/switch region; other site 83332008722 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 83332008723 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 83332008724 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 83332008725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332008726 motif II; other site 83332008727 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 83332008728 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 83332008729 D-pathway; other site 83332008730 Putative ubiquinol binding site [chemical binding]; other site 83332008731 Low-spin heme (heme b) binding site [chemical binding]; other site 83332008732 Putative water exit pathway; other site 83332008733 Binuclear center (heme o3/CuB) [ion binding]; other site 83332008734 K-pathway; other site 83332008735 Putative proton exit pathway; other site 83332008736 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 83332008737 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 83332008738 siderophore binding site; other site 83332008739 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 83332008740 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 83332008741 putative NAD(P) binding site [chemical binding]; other site 83332008742 putative substrate binding site [chemical binding]; other site 83332008743 catalytic Zn binding site [ion binding]; other site 83332008744 structural Zn binding site [ion binding]; other site 83332008745 dimer interface [polypeptide binding]; other site 83332008746 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 83332008747 chaperone protein DnaJ; Provisional; Region: PRK14289 83332008748 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 83332008749 dimer interface [polypeptide binding]; other site 83332008750 putative radical transfer pathway; other site 83332008751 diiron center [ion binding]; other site 83332008752 tyrosyl radical; other site 83332008753 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332008754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332008755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008757 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 83332008758 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 83332008759 Class I ribonucleotide reductase; Region: RNR_I; cd01679 83332008760 active site 83332008761 dimer interface [polypeptide binding]; other site 83332008762 catalytic residues [active] 83332008763 effector binding site; other site 83332008764 R2 peptide binding site; other site 83332008765 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 83332008766 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 83332008767 catalytic residues [active] 83332008768 Predicted flavoprotein [General function prediction only]; Region: COG0431 83332008769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008771 DNA polymerase IV; Validated; Region: PRK03352 83332008772 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 83332008773 active site 83332008774 DNA binding site [nucleotide binding] 83332008775 short chain dehydrogenase; Provisional; Region: PRK05650 83332008776 classical (c) SDRs; Region: SDR_c; cd05233 83332008777 NAD(P) binding site [chemical binding]; other site 83332008778 active site 83332008779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332008780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008781 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332008782 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332008783 DNA-binding site [nucleotide binding]; DNA binding site 83332008784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 83332008785 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 83332008786 Transcriptional regulators [Transcription]; Region: FadR; COG2186 83332008787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 83332008788 DNA-binding site [nucleotide binding]; DNA binding site 83332008789 FCD domain; Region: FCD; pfam07729 83332008790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008794 active site 83332008795 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 83332008796 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 83332008797 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 83332008798 active site 83332008799 DNA binding site [nucleotide binding] 83332008800 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 83332008801 DNA binding site [nucleotide binding] 83332008802 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 83332008803 Carbon starvation protein CstA; Region: CstA; pfam02554 83332008804 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 83332008805 Predicted membrane protein [Function unknown]; Region: COG2259 83332008806 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 83332008807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 83332008808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332008809 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332008810 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 83332008811 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 83332008812 active site 83332008813 substrate binding site [chemical binding]; other site 83332008814 metal binding site [ion binding]; metal-binding site 83332008815 camphor resistance protein CrcB; Provisional; Region: PRK14216 83332008816 camphor resistance protein CrcB; Provisional; Region: PRK14228 83332008817 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 83332008818 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 83332008819 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332008820 Uncharacterized conserved protein [Function unknown]; Region: COG3189 83332008821 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332008822 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332008823 active site 83332008824 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 83332008825 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 83332008826 putative hydrophobic ligand binding site [chemical binding]; other site 83332008827 protein interface [polypeptide binding]; other site 83332008828 gate; other site 83332008829 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332008830 Sulfatase; Region: Sulfatase; pfam00884 83332008831 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 83332008832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 83332008833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 83332008834 active site 83332008835 ATP binding site [chemical binding]; other site 83332008836 substrate binding site [chemical binding]; other site 83332008837 activation loop (A-loop); other site 83332008838 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 83332008839 AAA ATPase domain; Region: AAA_16; pfam13191 83332008840 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 83332008841 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332008842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332008843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332008844 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332008845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332008846 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 83332008847 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332008848 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 83332008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332008850 NAD(P) binding site [chemical binding]; other site 83332008851 active site 83332008852 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 83332008853 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 83332008854 NAD binding site [chemical binding]; other site 83332008855 catalytic Zn binding site [ion binding]; other site 83332008856 substrate binding site [chemical binding]; other site 83332008857 structural Zn binding site [ion binding]; other site 83332008858 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008859 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008860 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008861 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008862 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332008863 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 83332008864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332008865 acyl-activating enzyme (AAE) consensus motif; other site 83332008866 AMP binding site [chemical binding]; other site 83332008867 active site 83332008868 CoA binding site [chemical binding]; other site 83332008869 SPFH domain / Band 7 family; Region: Band_7; pfam01145 83332008870 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 83332008871 Patatin-like phospholipase; Region: Patatin; pfam01734 83332008872 nucleophile elbow; other site 83332008873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 83332008874 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 83332008875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332008876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332008877 active site 83332008878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332008879 dimerization interface [polypeptide binding]; other site 83332008880 putative DNA binding site [nucleotide binding]; other site 83332008881 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332008882 putative Zn2+ binding site [ion binding]; other site 83332008883 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 83332008884 PE family; Region: PE; pfam00934 83332008885 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332008886 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332008887 PemK-like protein; Region: PemK; pfam02452 83332008888 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332008889 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 83332008890 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332008891 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 83332008892 SmpB-tmRNA interface; other site 83332008893 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 83332008894 FtsX-like permease family; Region: FtsX; pfam02687 83332008895 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 83332008896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332008897 Walker A/P-loop; other site 83332008898 ATP binding site [chemical binding]; other site 83332008899 Q-loop/lid; other site 83332008900 ABC transporter signature motif; other site 83332008901 Walker B; other site 83332008902 D-loop; other site 83332008903 H-loop/switch region; other site 83332008904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 83332008905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 83332008906 peptide chain release factor 2; Validated; Region: prfB; PRK00578 83332008907 This domain is found in peptide chain release factors; Region: PCRF; smart00937 83332008908 RF-1 domain; Region: RF-1; pfam00472 83332008909 ferredoxin-NADP+ reductase; Region: PLN02852 83332008910 Bacterial protein of unknown function (DUF871); Region: DUF871; cl19843 83332008911 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332008912 FAD binding domain; Region: FAD_binding_4; pfam01565 83332008913 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 83332008914 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 83332008915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332008916 FeS/SAM binding site; other site 83332008917 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 83332008918 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 83332008919 aromatic arch; other site 83332008920 DCoH dimer interaction site [polypeptide binding]; other site 83332008921 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 83332008922 DCoH tetramer interaction site [polypeptide binding]; other site 83332008923 substrate binding site [chemical binding]; other site 83332008924 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332008925 trimer interface [polypeptide binding]; other site 83332008926 dimer interface [polypeptide binding]; other site 83332008927 putative active site [active] 83332008928 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332008929 MoaE interaction surface [polypeptide binding]; other site 83332008930 MoeB interaction surface [polypeptide binding]; other site 83332008931 thiocarboxylated glycine; other site 83332008932 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 83332008933 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 83332008934 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 83332008935 nucleoside/Zn binding site; other site 83332008936 dimer interface [polypeptide binding]; other site 83332008937 catalytic motif [active] 83332008938 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332008939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332008940 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 83332008941 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 83332008942 ATP binding site [chemical binding]; other site 83332008943 substrate interface [chemical binding]; other site 83332008944 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332008945 active site residue [active] 83332008946 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332008947 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332008948 active site residue [active] 83332008949 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332008950 active site residue [active] 83332008951 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 83332008952 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332008953 MoaE homodimer interface [polypeptide binding]; other site 83332008954 MoaD interaction [polypeptide binding]; other site 83332008955 active site residues [active] 83332008956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332008957 S-adenosylmethionine binding site [chemical binding]; other site 83332008958 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332008959 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 83332008960 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 83332008961 DNA binding site [nucleotide binding] 83332008962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008963 PPE family; Region: PPE; pfam00823 83332008964 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 83332008965 Rv3128c, (MTCY164.38c), len: 337 aa. Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 conserved hypothetical protein from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap). 83332008966 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 83332008967 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332008968 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332008969 Nitroreductase family; Region: Nitroreductase; pfam00881 83332008970 dimer interface [polypeptide binding]; other site 83332008971 Nitroreductase family; Region: Nitroreductase; pfam00881 83332008972 dimer interface [polypeptide binding]; other site 83332008973 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 83332008974 GAF domain; Region: GAF_3; pfam13492 83332008975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 83332008976 Histidine kinase; Region: HisKA_3; pfam07730 83332008977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332008978 ATP binding site [chemical binding]; other site 83332008979 Mg2+ binding site [ion binding]; other site 83332008980 G-X-G motif; other site 83332008981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 83332008982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332008983 active site 83332008984 phosphorylation site [posttranslational modification] 83332008985 intermolecular recognition site; other site 83332008986 dimerization interface [polypeptide binding]; other site 83332008987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 83332008988 DNA binding residues [nucleotide binding] 83332008989 dimerization interface [polypeptide binding]; other site 83332008990 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 83332008991 Ligand Binding Site [chemical binding]; other site 83332008992 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008993 PPE family; Region: PPE; pfam00823 83332008994 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332008995 PPE family; Region: PPE; pfam00823 83332008996 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332008997 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 83332008998 active site 83332008999 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 83332009000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332009001 FeS/SAM binding site; other site 83332009002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332009004 active site 83332009005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332009007 active site 83332009008 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 83332009009 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 83332009010 NAD(P) binding site [chemical binding]; other site 83332009011 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332009012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332009013 active site 83332009014 phosphorylation site [posttranslational modification] 83332009015 intermolecular recognition site; other site 83332009016 dimerization interface [polypeptide binding]; other site 83332009017 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009018 PPE family; Region: PPE; pfam00823 83332009019 NADH dehydrogenase subunit A; Validated; Region: PRK07928 83332009020 NADH dehydrogenase subunit B; Validated; Region: PRK06411 83332009021 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 83332009022 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 83332009023 NADH dehydrogenase subunit D; Validated; Region: PRK06075 83332009024 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 83332009025 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 83332009026 putative dimer interface [polypeptide binding]; other site 83332009027 [2Fe-2S] cluster binding site [ion binding]; other site 83332009028 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 83332009029 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 83332009030 SLBB domain; Region: SLBB; pfam10531 83332009031 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 83332009032 NADH dehydrogenase subunit G; Validated; Region: PRK07860 83332009033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332009034 catalytic loop [active] 83332009035 iron binding site [ion binding]; other site 83332009036 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 83332009037 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 83332009038 [4Fe-4S] binding site [ion binding]; other site 83332009039 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 83332009040 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 83332009041 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 83332009042 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 83332009043 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 83332009044 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 83332009045 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 83332009046 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 83332009047 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332009048 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 83332009049 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332009050 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 83332009051 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 83332009052 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009053 PPE family; Region: PPE; pfam00823 83332009054 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009055 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009056 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009057 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009058 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009059 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009060 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 83332009061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009062 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 83332009063 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 83332009064 [2Fe-2S] cluster binding site [ion binding]; other site 83332009065 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 83332009066 putative alpha subunit interface [polypeptide binding]; other site 83332009067 putative active site [active] 83332009068 putative substrate binding site [chemical binding]; other site 83332009069 Fe binding site [ion binding]; other site 83332009070 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332009071 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332009072 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332009073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332009074 Walker A motif; other site 83332009075 ATP binding site [chemical binding]; other site 83332009076 Walker B motif; other site 83332009077 arginine finger; other site 83332009078 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 83332009079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009081 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 83332009082 putative active site [active] 83332009083 putative substrate binding site [chemical binding]; other site 83332009084 ATP binding site [chemical binding]; other site 83332009085 Phosphotransferase enzyme family; Region: APH; pfam01636 83332009086 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 83332009087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332009088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332009090 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332009091 TAP-like protein; Region: Abhydrolase_4; pfam08386 83332009092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009094 short chain dehydrogenase; Validated; Region: PRK08264 83332009095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332009096 NAD(P) binding site [chemical binding]; other site 83332009097 active site 83332009098 amidase; Provisional; Region: PRK06170 83332009099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332009100 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332009101 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332009102 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332009103 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332009104 AAA domain; Region: AAA_14; pfam13173 83332009105 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 83332009106 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332009107 putative active site [active] 83332009108 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332009109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 83332009110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 83332009111 non-specific DNA binding site [nucleotide binding]; other site 83332009112 salt bridge; other site 83332009113 sequence-specific DNA binding site [nucleotide binding]; other site 83332009114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009115 Transposase; Region: HTH_Tnp_1; cl17663 83332009116 putative transposase OrfB; Reviewed; Region: PHA02517 83332009117 HTH-like domain; Region: HTH_21; pfam13276 83332009118 Integrase core domain; Region: rve; pfam00665 83332009119 Integrase core domain; Region: rve_3; pfam13683 83332009120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009121 Transposase; Region: HTH_Tnp_1; cl17663 83332009122 putative transposase OrfB; Reviewed; Region: PHA02517 83332009123 HTH-like domain; Region: HTH_21; pfam13276 83332009124 Integrase core domain; Region: rve; pfam00665 83332009125 Integrase core domain; Region: rve_3; pfam13683 83332009126 RES domain; Region: RES; pfam08808 83332009127 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 83332009128 Helix-turn-helix domain; Region: HTH_38; pfam13936 83332009129 Integrase core domain; Region: rve; pfam00665 83332009130 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 83332009131 hypothetical protein; Validated; Region: PRK00068 83332009132 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 83332009133 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 83332009134 Uncharacterized conserved protein [Function unknown]; Region: COG5282 83332009135 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 83332009136 ABC1 family; Region: ABC1; pfam03109 83332009137 Phosphotransferase enzyme family; Region: APH; pfam01636 83332009138 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 83332009139 active site 83332009140 ATP binding site [chemical binding]; other site 83332009141 Transcription factor WhiB; Region: Whib; pfam02467 83332009142 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 83332009143 Part of AAA domain; Region: AAA_19; pfam13245 83332009144 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 83332009145 HRDC domain; Region: HRDC; pfam00570 83332009146 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 83332009147 catalytic residues [active] 83332009148 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 83332009149 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 83332009150 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 83332009151 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 83332009152 putative NADH binding site [chemical binding]; other site 83332009153 putative active site [active] 83332009154 nudix motif; other site 83332009155 putative metal binding site [ion binding]; other site 83332009156 Ion channel; Region: Ion_trans_2; pfam07885 83332009157 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 83332009158 TrkA-N domain; Region: TrkA_N; pfam02254 83332009159 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 83332009160 Part of AAA domain; Region: AAA_19; pfam13245 83332009161 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332009162 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 83332009163 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 83332009164 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 83332009165 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 83332009166 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332009167 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332009168 catalytic site [active] 83332009169 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 83332009170 active site 83332009171 DNA binding site [nucleotide binding] 83332009172 TIGR02569 family protein; Region: TIGR02569_actnb 83332009173 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 83332009174 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 83332009175 ATP binding site [chemical binding]; other site 83332009176 substrate interface [chemical binding]; other site 83332009177 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 83332009178 active site residue [active] 83332009179 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 83332009180 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 83332009181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009183 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 83332009184 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 83332009185 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 83332009186 dinuclear metal binding motif [ion binding]; other site 83332009187 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 83332009188 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 83332009189 ATP binding site [chemical binding]; other site 83332009190 Mg++ binding site [ion binding]; other site 83332009191 motif III; other site 83332009192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332009193 nucleotide binding region [chemical binding]; other site 83332009194 ATP-binding site [chemical binding]; other site 83332009195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332009196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332009197 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332009198 P-loop; other site 83332009199 Magnesium ion binding site [ion binding]; other site 83332009200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332009201 catalytic core [active] 83332009202 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 83332009203 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 83332009204 Rv3216, (MTCY07D11.10c), len: 160 aa. Acetyltransferase (2.3.1.-), contains GNAT domain (Gcn5-related N-acetyltransferase. See Vetting et al. 2005), probably pseudogene as appears frameshifted due to 1bp insertion at position 3593438. Frameshift present in all sequenced tubercle bacilli. Start changed since first submission, extended by 50aa. Similar to many acetyltransferases e.g. Q9AB32|CC0402 acetyltransferase (GNAT family) from Caulobacter crescentus (159 aa), FASTA scores: opt: 325, E(): 3.8e-17, (45.65% identity in 103 aa overlap); P79081|ATS1 putative acetyltransferase ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa overlap). 83332009205 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 83332009206 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 83332009207 Transcription factor WhiB; Region: Whib; pfam02467 83332009208 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 83332009209 PAS domain S-box; Region: sensory_box; TIGR00229 83332009210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 83332009211 Histidine kinase; Region: HisKA_2; pfam07568 83332009212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009213 ATP binding site [chemical binding]; other site 83332009214 Mg2+ binding site [ion binding]; other site 83332009215 G-X-G motif; other site 83332009216 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332009217 carboxyltransferase (CT) interaction site; other site 83332009218 biotinylation site [posttranslational modification]; other site 83332009219 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 83332009220 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 83332009221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009222 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009223 DNA binding residues [nucleotide binding] 83332009224 short chain dehydrogenase; Provisional; Region: PRK08278 83332009225 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 83332009226 NAD(P) binding site [chemical binding]; other site 83332009227 homodimer interface [polypeptide binding]; other site 83332009228 active site 83332009229 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332009230 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 83332009231 putative deacylase active site [active] 83332009232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 83332009233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332009234 Coenzyme A binding pocket [chemical binding]; other site 83332009235 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 83332009236 Phosphotransferase enzyme family; Region: APH; pfam01636 83332009237 putative active site [active] 83332009238 putative substrate binding site [chemical binding]; other site 83332009239 ATP binding site [chemical binding]; other site 83332009240 Uncharacterized conserved protein [Function unknown]; Region: COG2135 83332009241 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 83332009242 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 83332009243 hinge; other site 83332009244 active site 83332009245 Predicted GTPases [General function prediction only]; Region: COG1162 83332009246 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 83332009247 GTPase/Zn-binding domain interface [polypeptide binding]; other site 83332009248 GTP/Mg2+ binding site [chemical binding]; other site 83332009249 G4 box; other site 83332009250 G5 box; other site 83332009251 G1 box; other site 83332009252 Switch I region; other site 83332009253 G2 box; other site 83332009254 G3 box; other site 83332009255 Switch II region; other site 83332009256 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 83332009257 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 83332009258 putative di-iron ligands [ion binding]; other site 83332009259 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 83332009260 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332009261 FAD binding pocket [chemical binding]; other site 83332009262 FAD binding motif [chemical binding]; other site 83332009263 phosphate binding motif [ion binding]; other site 83332009264 beta-alpha-beta structure motif; other site 83332009265 NAD binding pocket [chemical binding]; other site 83332009266 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332009267 catalytic loop [active] 83332009268 iron binding site [ion binding]; other site 83332009269 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 83332009270 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332009271 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332009272 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 83332009273 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 83332009274 TrkA-C domain; Region: TrkA_C; pfam02080 83332009275 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 83332009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332009277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332009278 putative substrate translocation pore; other site 83332009279 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332009280 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332009281 ligand binding site [chemical binding]; other site 83332009282 flexible hinge region; other site 83332009283 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332009284 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 83332009285 active site 83332009286 nucleophile elbow; other site 83332009287 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 83332009288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332009289 ATP binding site [chemical binding]; other site 83332009290 putative Mg++ binding site [ion binding]; other site 83332009291 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 83332009292 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 83332009293 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 83332009294 30S subunit binding site; other site 83332009295 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 83332009296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332009297 active site 83332009298 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 83332009299 lipoprotein LpqB; Provisional; Region: PRK13616 83332009300 Sporulation and spore germination; Region: Germane; pfam10646 83332009301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332009302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332009303 dimerization interface [polypeptide binding]; other site 83332009304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332009305 dimer interface [polypeptide binding]; other site 83332009306 phosphorylation site [posttranslational modification] 83332009307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009308 ATP binding site [chemical binding]; other site 83332009309 Mg2+ binding site [ion binding]; other site 83332009310 G-X-G motif; other site 83332009311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332009312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332009313 active site 83332009314 phosphorylation site [posttranslational modification] 83332009315 intermolecular recognition site; other site 83332009316 dimerization interface [polypeptide binding]; other site 83332009317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332009318 DNA binding site [nucleotide binding] 83332009319 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 83332009320 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 83332009321 TMP-binding site; other site 83332009322 ATP-binding site [chemical binding]; other site 83332009323 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 83332009324 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 83332009325 homotetramer interface [polypeptide binding]; other site 83332009326 ligand binding site [chemical binding]; other site 83332009327 catalytic site [active] 83332009328 NAD binding site [chemical binding]; other site 83332009329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009331 Rubredoxin [Energy production and conversion]; Region: COG1773 83332009332 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 83332009333 iron binding site [ion binding]; other site 83332009334 Rubredoxin [Energy production and conversion]; Region: COG1773 83332009335 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 83332009336 iron binding site [ion binding]; other site 83332009337 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 83332009338 Di-iron ligands [ion binding]; other site 83332009339 amino acid transporter; Region: 2A0306; TIGR00909 83332009340 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 83332009341 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 83332009342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009343 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 83332009344 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 83332009345 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 83332009346 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 83332009347 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 83332009348 active site 83332009349 substrate binding site [chemical binding]; other site 83332009350 metal binding site [ion binding]; metal-binding site 83332009351 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 83332009352 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 83332009353 Transcription factor WhiB; Region: Whib; pfam02467 83332009354 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 83332009355 phosphate binding site [ion binding]; other site 83332009356 dimer interface [polypeptide binding]; other site 83332009357 substrate binding site [chemical binding]; other site 83332009358 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 83332009359 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 83332009360 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 83332009361 putative FMN binding site [chemical binding]; other site 83332009362 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 83332009363 Methyltransferase domain; Region: Methyltransf_26; pfam13659 83332009364 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 83332009365 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 83332009366 active site 83332009367 Substrate binding site; other site 83332009368 Mg++ binding site; other site 83332009369 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 83332009370 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 83332009371 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 83332009372 Probable Catalytic site; other site 83332009373 metal-binding site 83332009374 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 83332009375 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 83332009376 NADP binding site [chemical binding]; other site 83332009377 active site 83332009378 putative substrate binding site [chemical binding]; other site 83332009379 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332009380 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332009381 TIGR03089 family protein; Region: TIGR03089 83332009382 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 83332009383 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332009384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332009385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009386 active site 83332009387 motif I; other site 83332009388 motif II; other site 83332009389 Cation efflux family; Region: Cation_efflux; cl00316 83332009390 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 83332009391 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 83332009392 Sulfate transporter family; Region: Sulfate_transp; pfam00916 83332009393 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 83332009394 active site clefts [active] 83332009395 zinc binding site [ion binding]; other site 83332009396 dimer interface [polypeptide binding]; other site 83332009397 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332009398 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 83332009399 FAD binding site [chemical binding]; other site 83332009400 homotetramer interface [polypeptide binding]; other site 83332009401 substrate binding pocket [chemical binding]; other site 83332009402 catalytic base [active] 83332009403 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 83332009404 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 83332009405 ATP-grasp domain; Region: ATP-grasp; pfam02222 83332009406 Predicted membrane protein [Function unknown]; Region: COG2246 83332009407 Bacterial PH domain; Region: bPH_2; pfam03703 83332009408 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 83332009409 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 83332009410 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 83332009411 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332009412 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332009413 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332009414 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 83332009415 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 83332009416 active site 83332009417 dimer interface [polypeptide binding]; other site 83332009418 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 83332009419 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 83332009420 active site residue [active] 83332009421 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 83332009422 active site residue [active] 83332009423 Fe-S metabolizm associated domain; Region: SufE; pfam02657 83332009424 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 83332009425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 83332009426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 83332009427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 83332009428 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 83332009429 carboxyltransferase (CT) interaction site; other site 83332009430 biotinylation site [posttranslational modification]; other site 83332009431 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 83332009432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009433 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 83332009434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009435 DNA binding residues [nucleotide binding] 83332009436 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 83332009437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332009438 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332009439 inhibitor-cofactor binding pocket; inhibition site 83332009440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009441 catalytic residue [active] 83332009442 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 83332009443 putative DNA binding site [nucleotide binding]; other site 83332009444 dimerization interface [polypeptide binding]; other site 83332009445 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 83332009446 putative Zn2+ binding site [ion binding]; other site 83332009447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 83332009448 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 83332009449 tetrameric interface [polypeptide binding]; other site 83332009450 NAD binding site [chemical binding]; other site 83332009451 catalytic residues [active] 83332009452 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 83332009453 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 83332009454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332009457 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 83332009458 ATP binding site [chemical binding]; other site 83332009459 putative Mg++ binding site [ion binding]; other site 83332009460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332009461 nucleotide binding region [chemical binding]; other site 83332009462 ATP-binding site [chemical binding]; other site 83332009463 DEAD/H associated; Region: DEAD_assoc; pfam08494 83332009464 Winged helix DNA-binding domain; Region: HTH_42; cl19833 83332009465 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 83332009466 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 83332009467 putative DNA binding site [nucleotide binding]; other site 83332009468 catalytic residue [active] 83332009469 putative H2TH interface [polypeptide binding]; other site 83332009470 putative catalytic residues [active] 83332009471 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 83332009472 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 83332009473 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 83332009474 Sulfatase; Region: Sulfatase; pfam00884 83332009475 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 83332009476 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 83332009477 probable active site [active] 83332009478 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 83332009479 PhoU domain; Region: PhoU; pfam01895 83332009480 PhoU domain; Region: PhoU; pfam01895 83332009481 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 83332009482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009483 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 83332009484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332009486 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 83332009487 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 83332009488 putative active site pocket [active] 83332009489 dimerization interface [polypeptide binding]; other site 83332009490 putative catalytic residue [active] 83332009491 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 83332009492 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 83332009493 metal binding site [ion binding]; metal-binding site 83332009494 putative dimer interface [polypeptide binding]; other site 83332009495 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 83332009496 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 83332009497 metal binding site [ion binding]; metal-binding site 83332009498 purine nucleoside phosphorylase; Provisional; Region: PRK08202 83332009499 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 83332009500 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 83332009501 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 83332009502 active site 83332009503 substrate binding site [chemical binding]; other site 83332009504 metal binding site [ion binding]; metal-binding site 83332009505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332009506 active site 83332009507 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 83332009508 Phosphoesterase family; Region: Phosphoesterase; pfam04185 83332009509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332009510 adenosine deaminase; Provisional; Region: PRK09358 83332009511 active site 83332009512 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 83332009513 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 83332009514 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 83332009515 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 83332009516 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 83332009517 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 83332009518 active site 83332009519 catalytic motif [active] 83332009520 Zn binding site [ion binding]; other site 83332009521 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 83332009522 putative Iron-sulfur protein interface [polypeptide binding]; other site 83332009523 putative proximal heme binding site [chemical binding]; other site 83332009524 putative SdhD-like interface [polypeptide binding]; other site 83332009525 putative distal heme binding site [chemical binding]; other site 83332009526 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 83332009527 putative Iron-sulfur protein interface [polypeptide binding]; other site 83332009528 putative proximal heme binding site [chemical binding]; other site 83332009529 putative SdhC-like subunit interface [polypeptide binding]; other site 83332009530 putative distal heme binding site [chemical binding]; other site 83332009531 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 83332009532 L-aspartate oxidase; Provisional; Region: PRK06175 83332009533 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 83332009534 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 83332009535 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 83332009536 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 83332009537 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 83332009538 putative active site [active] 83332009539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009540 S-adenosylmethionine binding site [chemical binding]; other site 83332009541 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 83332009542 MoaE interaction surface [polypeptide binding]; other site 83332009543 MoeB interaction surface [polypeptide binding]; other site 83332009544 thiocarboxylated glycine; other site 83332009545 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 83332009546 MoaE homodimer interface [polypeptide binding]; other site 83332009547 MoaD interaction [polypeptide binding]; other site 83332009548 active site residues [active] 83332009549 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 83332009550 trimer interface [polypeptide binding]; other site 83332009551 dimer interface [polypeptide binding]; other site 83332009552 putative active site [active] 83332009553 Rv3324A, len: 44 aa. Probable pseudogene moaB3,fragment of pterin-4-alpha-carbinolamine dehydratase,equivalent to C-terminus of MT3426|Q8VJ32 pterin-4-alpha-carbinolamine dehydratase from Mycobacterium tuberculosis strain CDC1551 (124 aa), FASTA scores: opt: 309, E(): 1.1e-20, (100.000% identity in 44 aa overlap),and C-terminus of Mb3354c|moaB3 probable pterin-4-alpha-carbinolamine dehydratase from Mycobacterium bovis (124 aa). Note that a deletion of DNA (RvD5 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below). 83332009554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009555 Transposase; Region: HTH_Tnp_1; cl17663 83332009556 putative transposase OrfB; Reviewed; Region: PHA02517 83332009557 HTH-like domain; Region: HTH_21; pfam13276 83332009558 Integrase core domain; Region: rve; pfam00665 83332009559 Integrase core domain; Region: rve_3; pfam13683 83332009560 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332009561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 83332009562 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 83332009563 Uncharacterized conserved protein [Function unknown]; Region: COG2128 83332009564 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 83332009565 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 83332009566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009567 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 83332009568 DNA binding residues [nucleotide binding] 83332009569 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332009570 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 83332009571 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 83332009572 inhibitor-cofactor binding pocket; inhibition site 83332009573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009574 catalytic residue [active] 83332009575 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 83332009576 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 83332009577 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 83332009578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332009579 putative substrate translocation pore; other site 83332009580 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 83332009581 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 83332009582 active site 83332009583 dimer interface [polypeptide binding]; other site 83332009584 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332009585 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 83332009586 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 83332009587 DNA binding residues [nucleotide binding] 83332009588 dimer interface [polypeptide binding]; other site 83332009589 metal binding site [ion binding]; metal-binding site 83332009590 inner membrane protein YhjD; Region: TIGR00766 83332009591 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 83332009592 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 83332009593 active site 83332009594 HIGH motif; other site 83332009595 dimer interface [polypeptide binding]; other site 83332009596 KMSKS motif; other site 83332009597 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332009598 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 83332009599 isocitrate dehydrogenase; Validated; Region: PRK08299 83332009600 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 83332009601 homodimer interface [polypeptide binding]; other site 83332009602 substrate-cofactor binding pocket; other site 83332009603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009604 catalytic residue [active] 83332009605 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 83332009606 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 83332009607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009608 S-adenosylmethionine binding site [chemical binding]; other site 83332009609 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009610 PPE family; Region: PPE; pfam00823 83332009611 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009612 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009613 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009614 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009615 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009616 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009617 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009618 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009619 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009620 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009621 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009622 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009623 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009624 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009625 PE family; Region: PE; pfam00934 83332009626 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 83332009627 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009628 PPE family; Region: PPE; pfam00823 83332009629 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009630 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009631 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009632 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009633 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009634 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009635 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009636 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009637 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009638 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009639 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009640 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009641 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009642 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009643 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009644 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009645 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009646 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009647 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009648 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009649 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009650 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009651 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009652 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332009653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332009654 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332009655 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009656 PPE family; Region: PPE; pfam00823 83332009657 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009658 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009659 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009660 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009661 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009662 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009663 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009664 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009665 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009666 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009667 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009668 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009669 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009670 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009671 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009672 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009673 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009674 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009675 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009676 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009677 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009678 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009679 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009680 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009681 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009682 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009683 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009684 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009685 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009686 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009687 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332009688 Berberine and berberine like; Region: BBE; pfam08031 83332009689 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332009690 Protein of unknown function (DUF732); Region: DUF732; pfam05305 83332009691 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 83332009692 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 83332009693 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 83332009694 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 83332009695 homodimer interface [polypeptide binding]; other site 83332009696 NADP binding site [chemical binding]; other site 83332009697 substrate binding site [chemical binding]; other site 83332009698 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 83332009699 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 83332009700 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 83332009701 active site 83332009702 FMN binding site [chemical binding]; other site 83332009703 substrate binding site [chemical binding]; other site 83332009704 putative catalytic residue [active] 83332009705 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332009706 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 83332009707 phosphopeptide binding site; other site 83332009708 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 83332009709 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 83332009710 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 83332009711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 83332009712 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 83332009713 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 83332009714 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 83332009715 G1 box; other site 83332009716 GTP/Mg2+ binding site [chemical binding]; other site 83332009717 G2 box; other site 83332009718 Switch I region; other site 83332009719 G3 box; other site 83332009720 Switch II region; other site 83332009721 G4 box; other site 83332009722 G5 box; other site 83332009723 Protein of unknown function (DUF742); Region: DUF742; pfam05331 83332009724 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 83332009725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332009726 HAMP domain; Region: HAMP; pfam00672 83332009727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332009728 ATP binding site [chemical binding]; other site 83332009729 Mg2+ binding site [ion binding]; other site 83332009730 G-X-G motif; other site 83332009731 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 83332009732 PE family; Region: PE; pfam00934 83332009733 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 83332009734 FMN binding site [chemical binding]; other site 83332009735 dimer interface [polypeptide binding]; other site 83332009736 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 83332009737 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 83332009738 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 83332009739 active site 83332009740 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 83332009741 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 83332009742 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 83332009743 generic binding surface II; other site 83332009744 generic binding surface I; other site 83332009745 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332009746 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332009747 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 83332009748 trehalose-phosphatase; Region: T6PP; TIGR00685 83332009749 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 83332009750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009751 active site 83332009752 motif I; other site 83332009753 motif II; other site 83332009754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332009755 substrate binding site [chemical binding]; other site 83332009756 oxyanion hole (OAH) forming residues; other site 83332009757 trimer interface [polypeptide binding]; other site 83332009758 enoyl-CoA hydratase; Provisional; Region: PRK06144 83332009759 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 83332009760 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 83332009761 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 83332009762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009763 motif II; other site 83332009764 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 83332009765 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 83332009766 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 83332009767 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 83332009768 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 83332009769 TPP-binding site [chemical binding]; other site 83332009770 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 83332009771 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 83332009772 PYR/PP interface [polypeptide binding]; other site 83332009773 dimer interface [polypeptide binding]; other site 83332009774 TPP binding site [chemical binding]; other site 83332009775 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 83332009776 putative transposase OrfB; Reviewed; Region: PHA02517 83332009777 HTH-like domain; Region: HTH_21; pfam13276 83332009778 Integrase core domain; Region: rve; pfam00665 83332009779 Integrase core domain; Region: rve_3; pfam13683 83332009780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332009781 Transposase; Region: HTH_Tnp_1; cl17663 83332009782 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 83332009783 Fe-S cluster binding site [ion binding]; other site 83332009784 substrate binding site [chemical binding]; other site 83332009785 catalytic site [active] 83332009786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332009787 substrate binding pocket [chemical binding]; other site 83332009788 chain length determination region; other site 83332009789 substrate-Mg2+ binding site; other site 83332009790 catalytic residues [active] 83332009791 aspartate-rich region 1; other site 83332009792 active site lid residues [active] 83332009793 aspartate-rich region 2; other site 83332009794 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332009795 putative active site [active] 83332009796 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332009797 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332009798 Transposase domain (DUF772); Region: DUF772; pfam05598 83332009799 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 83332009800 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 83332009801 PE family; Region: PE; pfam00934 83332009802 enoyl-CoA hydratase; Region: PLN02864 83332009803 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332009804 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 83332009805 dimer interaction site [polypeptide binding]; other site 83332009806 substrate-binding tunnel; other site 83332009807 active site 83332009808 catalytic site [active] 83332009809 substrate binding site [chemical binding]; other site 83332009810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332009811 short chain dehydrogenase; Provisional; Region: PRK07201 83332009812 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 83332009813 putative NAD(P) binding site [chemical binding]; other site 83332009814 active site 83332009815 putative substrate binding site [chemical binding]; other site 83332009816 classical (c) SDRs; Region: SDR_c; cd05233 83332009817 NAD(P) binding site [chemical binding]; other site 83332009818 active site 83332009819 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332009820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 83332009821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332009822 S-adenosylmethionine binding site [chemical binding]; other site 83332009823 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 83332009824 active site 83332009825 DNA Polymerase Y-family; Region: PolY_like; cd03468 83332009826 active site 83332009827 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 83332009828 DNA binding site [nucleotide binding] 83332009829 GMP synthase; Reviewed; Region: guaA; PRK00074 83332009830 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 83332009831 AMP/PPi binding site [chemical binding]; other site 83332009832 candidate oxyanion hole; other site 83332009833 catalytic triad [active] 83332009834 potential glutamine specificity residues [chemical binding]; other site 83332009835 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 83332009836 ATP Binding subdomain [chemical binding]; other site 83332009837 Ligand Binding sites [chemical binding]; other site 83332009838 Dimerization subdomain; other site 83332009839 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 83332009840 active site lid residues [active] 83332009841 substrate binding pocket [chemical binding]; other site 83332009842 catalytic residues [active] 83332009843 substrate-Mg2+ binding site; other site 83332009844 aspartate-rich region 1; other site 83332009845 aspartate-rich region 2; other site 83332009846 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 83332009847 substrate binding pocket [chemical binding]; other site 83332009848 chain length determination region; other site 83332009849 substrate-Mg2+ binding site; other site 83332009850 catalytic residues [active] 83332009851 aspartate-rich region 1; other site 83332009852 active site lid residues [active] 83332009853 aspartate-rich region 2; other site 83332009854 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332009855 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 83332009856 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 83332009857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332009858 motif II; other site 83332009859 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 83332009860 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 83332009861 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 83332009862 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 83332009863 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 83332009864 inhibitor-cofactor binding pocket; inhibition site 83332009865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009866 catalytic residue [active] 83332009867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 83332009868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009869 hypothetical protein; Provisional; Region: PRK07579 83332009870 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 83332009871 active site 83332009872 cosubstrate binding site; other site 83332009873 substrate binding site [chemical binding]; other site 83332009874 catalytic site [active] 83332009875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332009876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332009877 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 83332009878 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 83332009879 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 83332009880 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 83332009881 putative active site [active] 83332009882 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 83332009883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332009884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332009885 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 83332009886 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 83332009887 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 83332009888 phosphate binding site [ion binding]; other site 83332009889 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 83332009890 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 83332009891 active site 83332009892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 83332009893 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 83332009894 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332009895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 83332009896 DNA binding residues [nucleotide binding] 83332009897 tetratricopeptide repeat protein; Provisional; Region: PRK11788 83332009898 Transcription factor WhiB; Region: Whib; pfam02467 83332009899 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 83332009900 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 83332009901 ring oligomerisation interface [polypeptide binding]; other site 83332009902 ATP/Mg binding site [chemical binding]; other site 83332009903 stacking interactions; other site 83332009904 hinge regions; other site 83332009905 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 83332009906 oligomerisation interface [polypeptide binding]; other site 83332009907 mobile loop; other site 83332009908 roof hairpin; other site 83332009909 UGMP family protein; Validated; Region: PRK09604 83332009910 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 83332009911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 83332009912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 83332009913 Coenzyme A binding pocket [chemical binding]; other site 83332009914 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 83332009915 Glycoprotease family; Region: Peptidase_M22; pfam00814 83332009916 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 83332009917 alanine racemase; Reviewed; Region: alr; PRK00053 83332009918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 83332009919 active site 83332009920 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 83332009921 dimer interface [polypeptide binding]; other site 83332009922 substrate binding site [chemical binding]; other site 83332009923 catalytic residues [active] 83332009924 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009925 PPE family; Region: PPE; pfam00823 83332009926 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009927 PPE family; Region: PPE; pfam00823 83332009928 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 83332009929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332009930 Walker A motif; other site 83332009931 ATP binding site [chemical binding]; other site 83332009932 Walker B motif; other site 83332009933 arginine finger; other site 83332009934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332009935 Integrase core domain; Region: rve; pfam00665 83332009936 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332009937 PPE family; Region: PPE; pfam00823 83332009938 putative transposase OrfB; Reviewed; Region: PHA02517 83332009939 Integrase core domain; Region: rve; pfam00665 83332009940 Integrase core domain; Region: rve_3; pfam13683 83332009941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332009942 Transposase, Mutator family; Region: Transposase_mut; cl19537 83332009943 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 83332009944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332009945 catalytic residue [active] 83332009946 Uncharacterized conserved protein [Function unknown]; Region: COG0062 83332009947 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 83332009948 putative substrate binding site [chemical binding]; other site 83332009949 putative ATP binding site [chemical binding]; other site 83332009950 Domain of unknown function (DUF4436); Region: DUF4436; pfam14494 83332009951 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 83332009952 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 83332009953 glutaminase active site [active] 83332009954 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 83332009955 dimer interface [polypeptide binding]; other site 83332009956 active site 83332009957 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 83332009958 dimer interface [polypeptide binding]; other site 83332009959 active site 83332009960 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 83332009961 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332009962 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 83332009963 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 83332009964 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 83332009965 active site 83332009966 substrate binding site [chemical binding]; other site 83332009967 metal binding site [ion binding]; metal-binding site 83332009968 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 83332009969 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 83332009970 23S rRNA interface [nucleotide binding]; other site 83332009971 L3 interface [polypeptide binding]; other site 83332009972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332009973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332009974 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 83332009975 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332009976 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009977 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332009978 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009979 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332009980 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332009981 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332009982 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332009983 active site 83332009984 catalytic residues [active] 83332009985 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332009986 Cutinase; Region: Cutinase; pfam01083 83332009987 Cutinase; Region: Cutinase; pfam01083 83332009988 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 83332009989 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 83332009990 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 83332009991 active site 83332009992 dimerization interface 3.5A [polypeptide binding]; other site 83332009993 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 83332009994 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 83332009995 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 83332009996 alphaNTD - beta interaction site [polypeptide binding]; other site 83332009997 alphaNTD homodimer interface [polypeptide binding]; other site 83332009998 alphaNTD - beta' interaction site [polypeptide binding]; other site 83332009999 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 83332010000 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 83332010001 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 83332010002 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 83332010003 RNA binding surface [nucleotide binding]; other site 83332010004 30S ribosomal protein S11; Validated; Region: PRK05309 83332010005 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 83332010006 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 83332010007 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 83332010008 rRNA binding site [nucleotide binding]; other site 83332010009 predicted 30S ribosome binding site; other site 83332010010 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 83332010011 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 83332010012 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 83332010013 NAD binding site [chemical binding]; other site 83332010014 substrate binding site [chemical binding]; other site 83332010015 homodimer interface [polypeptide binding]; other site 83332010016 active site 83332010017 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 83332010018 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332010019 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332010020 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332010021 active site 83332010022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332010023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010024 NAD(P) binding site [chemical binding]; other site 83332010025 active site 83332010026 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 83332010027 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 83332010028 active site 83332010029 catalytic residues [active] 83332010030 metal binding site [ion binding]; metal-binding site 83332010031 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 83332010032 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332010033 PYR/PP interface [polypeptide binding]; other site 83332010034 dimer interface [polypeptide binding]; other site 83332010035 TPP binding site [chemical binding]; other site 83332010036 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 83332010037 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 83332010038 TPP-binding site [chemical binding]; other site 83332010039 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 83332010040 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 83332010041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332010042 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332010043 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 83332010045 Transposase; Region: HTH_Tnp_1; cl17663 83332010046 putative transposase OrfB; Reviewed; Region: PHA02517 83332010047 HTH-like domain; Region: HTH_21; pfam13276 83332010048 Integrase core domain; Region: rve; pfam00665 83332010049 Integrase core domain; Region: rve_3; pfam13683 83332010050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332010051 metabolite-proton symporter; Region: 2A0106; TIGR00883 83332010052 putative substrate translocation pore; other site 83332010053 PE family; Region: PE; pfam00934 83332010054 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010055 PPE family; Region: PPE; pfam00823 83332010056 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332010057 patatin-related protein; Region: TIGR03607 83332010058 Patatin-like phospholipase; Region: Patatin; pfam01734 83332010059 nucleophile elbow; other site 83332010060 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 83332010061 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332010062 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332010063 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 83332010064 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332010065 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 83332010066 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 83332010067 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332010068 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 83332010069 short chain dehydrogenase; Provisional; Region: PRK07774 83332010070 classical (c) SDRs; Region: SDR_c; cd05233 83332010071 NAD(P) binding site [chemical binding]; other site 83332010072 active site 83332010073 Predicted membrane protein [Function unknown]; Region: COG2259 83332010074 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 83332010075 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 83332010076 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 83332010077 Transcriptional regulators [Transcription]; Region: MarR; COG1846 83332010078 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 83332010079 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 83332010080 active site 83332010081 homotetramer interface [polypeptide binding]; other site 83332010082 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010083 mce related protein; Region: MCE; pfam02470 83332010084 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010085 mce related protein; Region: MCE; pfam02470 83332010086 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010087 mce related protein; Region: MCE; pfam02470 83332010088 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332010089 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010090 mce related protein; Region: MCE; pfam02470 83332010091 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010092 mce related protein; Region: MCE; pfam02470 83332010093 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332010094 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 83332010095 mce related protein; Region: MCE; pfam02470 83332010096 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 83332010097 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332010098 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 83332010099 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 83332010100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010101 NAD(P) binding site [chemical binding]; other site 83332010102 active site 83332010103 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 83332010104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010105 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 83332010106 FAD binding site [chemical binding]; other site 83332010107 substrate binding site [chemical binding]; other site 83332010108 catalytic base [active] 83332010109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010110 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010111 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 83332010112 active site 83332010113 acyl-CoA synthetase; Validated; Region: PRK07867 83332010114 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 83332010115 acyl-activating enzyme (AAE) consensus motif; other site 83332010116 putative AMP binding site [chemical binding]; other site 83332010117 putative active site [active] 83332010118 putative CoA binding site [chemical binding]; other site 83332010119 PE family; Region: PE; pfam00934 83332010120 PE family; Region: PE; pfam00934 83332010121 hypothetical protein; Validated; Region: PRK07586 83332010122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 83332010123 PYR/PP interface [polypeptide binding]; other site 83332010124 dimer interface [polypeptide binding]; other site 83332010125 TPP binding site [chemical binding]; other site 83332010126 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 83332010127 TPP-binding site [chemical binding]; other site 83332010128 dimer interface [polypeptide binding]; other site 83332010129 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 83332010130 PE family; Region: PE; pfam00934 83332010131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332010132 CoA binding site [chemical binding]; other site 83332010133 PE family; Region: PE; pfam00934 83332010134 acyl-CoA synthetase; Validated; Region: PRK07798 83332010135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332010136 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 83332010137 acyl-activating enzyme (AAE) consensus motif; other site 83332010138 acyl-activating enzyme (AAE) consensus motif; other site 83332010139 putative AMP binding site [chemical binding]; other site 83332010140 putative active site [active] 83332010141 putative CoA binding site [chemical binding]; other site 83332010142 enoyl-CoA hydratase; Provisional; Region: PRK07799 83332010143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332010144 substrate binding site [chemical binding]; other site 83332010145 oxyanion hole (OAH) forming residues; other site 83332010146 trimer interface [polypeptide binding]; other site 83332010147 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332010148 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332010149 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 83332010150 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 83332010151 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 83332010152 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332010153 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332010154 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332010155 lipid-transfer protein; Provisional; Region: PRK07937 83332010156 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 83332010157 active site 83332010158 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 83332010159 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332010160 active site 83332010161 Uncharacterized conserved protein [Function unknown]; Region: COG3391 83332010162 NHL repeat; Region: NHL; pfam01436 83332010163 NHL repeat; Region: NHL; pfam01436 83332010164 NHL repeat; Region: NHL; pfam01436 83332010165 NHL repeat; Region: NHL; pfam01436 83332010166 NHL repeat; Region: NHL; pfam01436 83332010167 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 83332010168 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 83332010169 trimer interface [polypeptide binding]; other site 83332010170 putative metal binding site [ion binding]; other site 83332010171 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 83332010172 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 83332010173 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 83332010174 short chain dehydrogenase; Provisional; Region: PRK07890 83332010175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010176 NAD(P) binding site [chemical binding]; other site 83332010177 active site 83332010178 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010179 PPE family; Region: PPE; pfam00823 83332010180 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332010181 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010182 PPE family; Region: PPE; pfam00823 83332010183 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010184 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010185 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010186 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010187 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010188 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010189 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010190 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 83332010191 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 83332010192 active site 83332010193 catalytic residues [active] 83332010194 metal binding site [ion binding]; metal-binding site 83332010195 DmpG-like communication domain; Region: DmpG_comm; pfam07836 83332010196 acetaldehyde dehydrogenase; Validated; Region: PRK08300 83332010197 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 83332010198 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 83332010199 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 83332010200 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 83332010201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332010202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332010203 enoyl-CoA hydratase; Region: PLN02864 83332010204 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 83332010205 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 83332010206 dimer interaction site [polypeptide binding]; other site 83332010207 substrate-binding tunnel; other site 83332010208 active site 83332010209 catalytic site [active] 83332010210 substrate binding site [chemical binding]; other site 83332010211 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010212 PPE family; Region: PPE; pfam00823 83332010213 PE-PPE domain; Region: PE-PPE; pfam08237 83332010214 lipid-transfer protein; Provisional; Region: PRK07855 83332010215 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 83332010216 active site 83332010217 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 83332010218 putative active site [active] 83332010219 putative catalytic site [active] 83332010220 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 83332010221 active site 83332010222 catalytic site [active] 83332010223 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 83332010224 DUF35 OB-fold domain; Region: DUF35; pfam01796 83332010225 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010226 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010227 active site 83332010228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010229 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010231 active site 83332010232 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332010233 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 83332010234 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332010235 dimer interface [polypeptide binding]; other site 83332010236 active site 83332010237 Domain of unknown function (DUF385); Region: DUF385; pfam04075 83332010238 short chain dehydrogenase; Provisional; Region: PRK07791 83332010239 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 83332010240 homodimer interface [polypeptide binding]; other site 83332010241 NAD binding site [chemical binding]; other site 83332010242 active site 83332010243 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 83332010244 classical (c) SDRs; Region: SDR_c; cd05233 83332010245 NAD(P) binding site [chemical binding]; other site 83332010246 active site 83332010247 enoyl-CoA hydratase; Provisional; Region: PRK07938 83332010248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332010249 substrate binding site [chemical binding]; other site 83332010250 oxyanion hole (OAH) forming residues; other site 83332010251 trimer interface [polypeptide binding]; other site 83332010252 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 83332010253 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 83332010254 Nitronate monooxygenase; Region: NMO; pfam03060 83332010255 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 83332010256 FMN binding site [chemical binding]; other site 83332010257 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 83332010258 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 83332010259 putative di-iron ligands [ion binding]; other site 83332010260 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 83332010261 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 83332010262 FAD binding pocket [chemical binding]; other site 83332010263 FAD binding motif [chemical binding]; other site 83332010264 phosphate binding motif [ion binding]; other site 83332010265 beta-alpha-beta structure motif; other site 83332010266 NAD(p) ribose binding residues [chemical binding]; other site 83332010267 NAD binding pocket [chemical binding]; other site 83332010268 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 83332010269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332010270 catalytic loop [active] 83332010271 iron binding site [ion binding]; other site 83332010272 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 83332010273 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332010274 putative active site [active] 83332010275 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 83332010276 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 83332010277 dimer interface [polypeptide binding]; other site 83332010278 active site 83332010279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332010280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010281 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010282 PPE family; Region: PPE; pfam00823 83332010283 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010284 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010285 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 83332010286 short chain dehydrogenase; Provisional; Region: PRK07831 83332010287 classical (c) SDRs; Region: SDR_c; cd05233 83332010288 NAD(P) binding site [chemical binding]; other site 83332010289 active site 83332010290 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 83332010291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010292 active site 83332010293 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 83332010294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 83332010295 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 83332010296 acyl-activating enzyme (AAE) consensus motif; other site 83332010297 acyl-activating enzyme (AAE) consensus motif; other site 83332010298 putative AMP binding site [chemical binding]; other site 83332010299 putative active site [active] 83332010300 putative CoA binding site [chemical binding]; other site 83332010301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010302 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010303 active site 83332010304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010305 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 83332010306 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010307 active site 83332010308 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010310 active site 83332010311 aspartate aminotransferase; Provisional; Region: PRK05764 83332010312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332010313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332010314 homodimer interface [polypeptide binding]; other site 83332010315 catalytic residue [active] 83332010316 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 83332010317 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 83332010318 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 83332010319 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 83332010320 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 83332010321 active site 83332010322 Fe binding site [ion binding]; other site 83332010323 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 83332010324 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010326 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 83332010327 Flavin binding site [chemical binding]; other site 83332010328 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 83332010329 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 83332010330 FAD binding pocket [chemical binding]; other site 83332010331 FAD binding motif [chemical binding]; other site 83332010332 phosphate binding motif [ion binding]; other site 83332010333 beta-alpha-beta structure motif; other site 83332010334 NAD(p) ribose binding residues [chemical binding]; other site 83332010335 NAD binding pocket [chemical binding]; other site 83332010336 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 83332010337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 83332010338 catalytic loop [active] 83332010339 iron binding site [ion binding]; other site 83332010340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 83332010343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 83332010344 active site 83332010345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332010346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332010347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 83332010348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 83332010349 DNA binding site [nucleotide binding] 83332010350 domain linker motif; other site 83332010351 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 83332010352 putative dimerization interface [polypeptide binding]; other site 83332010353 putative ligand binding site [chemical binding]; other site 83332010354 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332010355 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332010356 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 83332010357 transmembrane helices; other site 83332010358 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 83332010359 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 83332010360 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 83332010361 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 83332010362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 83332010363 active site 83332010364 HIGH motif; other site 83332010365 KMSKS motif; other site 83332010366 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 83332010367 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 83332010368 homotrimer interaction site [polypeptide binding]; other site 83332010369 zinc binding site [ion binding]; other site 83332010370 CDP-binding sites; other site 83332010371 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 83332010372 substrate binding site; other site 83332010373 dimer interface; other site 83332010374 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 83332010375 DNA repair protein RadA; Provisional; Region: PRK11823 83332010376 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 83332010377 Walker A motif/ATP binding site; other site 83332010378 ATP binding site [chemical binding]; other site 83332010379 Walker B motif; other site 83332010380 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 83332010381 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 83332010382 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 83332010383 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 83332010384 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 83332010385 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 83332010386 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 83332010387 active site clefts [active] 83332010388 zinc binding site [ion binding]; other site 83332010389 dimer interface [polypeptide binding]; other site 83332010390 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 83332010391 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332010392 minor groove reading motif; other site 83332010393 helix-hairpin-helix signature motif; other site 83332010394 substrate binding pocket [chemical binding]; other site 83332010395 active site 83332010396 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 83332010397 PE family; Region: PE; pfam00934 83332010398 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332010400 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 83332010401 catalytic site [active] 83332010402 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 83332010403 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 83332010404 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 83332010405 Ami_2 domain; Region: Ami_2; smart00644 83332010406 amidase catalytic site [active] 83332010407 Zn binding residues [ion binding]; other site 83332010408 substrate binding site [chemical binding]; other site 83332010409 PE family; Region: PE; pfam00934 83332010410 Clp protease ATP binding subunit; Region: clpC; CHL00095 83332010411 Clp amino terminal domain; Region: Clp_N; pfam02861 83332010412 Clp amino terminal domain; Region: Clp_N; pfam02861 83332010413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010414 Walker A motif; other site 83332010415 ATP binding site [chemical binding]; other site 83332010416 Walker B motif; other site 83332010417 arginine finger; other site 83332010418 UvrB/uvrC motif; Region: UVR; pfam02151 83332010419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010420 Walker A motif; other site 83332010421 ATP binding site [chemical binding]; other site 83332010422 Walker B motif; other site 83332010423 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 83332010424 Lsr2; Region: Lsr2; pfam11774 83332010425 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 83332010426 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 83332010427 dimer interface [polypeptide binding]; other site 83332010428 putative anticodon binding site; other site 83332010429 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 83332010430 motif 1; other site 83332010431 dimer interface [polypeptide binding]; other site 83332010432 active site 83332010433 motif 2; other site 83332010434 motif 3; other site 83332010435 pantothenate kinase; Reviewed; Region: PRK13318 83332010436 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 83332010437 tetramerization interface [polypeptide binding]; other site 83332010438 active site 83332010439 Pantoate-beta-alanine ligase; Region: PanC; cd00560 83332010440 active site 83332010441 ATP-binding site [chemical binding]; other site 83332010442 pantoate-binding site; other site 83332010443 HXXH motif; other site 83332010444 Uncharacterized conserved protein [Function unknown]; Region: COG5495 83332010445 Rossmann-like domain; Region: Rossmann-like; pfam10727 83332010446 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 83332010447 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 83332010448 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 83332010449 catalytic center binding site [active] 83332010450 ATP binding site [chemical binding]; other site 83332010451 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 83332010452 homooctamer interface [polypeptide binding]; other site 83332010453 active site 83332010454 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 83332010455 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 83332010456 substrate binding pocket [chemical binding]; other site 83332010457 dimer interface [polypeptide binding]; other site 83332010458 inhibitor binding site; inhibition site 83332010459 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 83332010460 active site 83332010461 FtsH Extracellular; Region: FtsH_ext; pfam06480 83332010462 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 83332010463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010464 Walker A motif; other site 83332010465 ATP binding site [chemical binding]; other site 83332010466 Walker B motif; other site 83332010467 arginine finger; other site 83332010468 Peptidase family M41; Region: Peptidase_M41; pfam01434 83332010469 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 83332010470 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332010471 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 83332010472 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010473 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010474 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 83332010475 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332010476 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332010477 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010478 PPE family; Region: PPE; pfam00823 83332010479 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 83332010480 PE family; Region: PE; pfam00934 83332010481 Uncharacterized conserved protein [Function unknown]; Region: COG2968 83332010482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 83332010483 active site 83332010484 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 83332010485 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 83332010486 Ligand Binding Site [chemical binding]; other site 83332010487 TilS substrate binding domain; Region: TilS; pfam09179 83332010488 Uncharacterized conserved protein [Function unknown]; Region: COG5282 83332010489 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 83332010490 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 83332010491 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 83332010492 dimer interface [polypeptide binding]; other site 83332010493 substrate binding site [chemical binding]; other site 83332010494 metal binding sites [ion binding]; metal-binding site 83332010495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 83332010496 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332010497 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 83332010498 Ligand binding site; other site 83332010499 Putative Catalytic site; other site 83332010500 DXD motif; other site 83332010501 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 83332010502 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 83332010503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332010504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010505 NAD(P) binding site [chemical binding]; other site 83332010506 active site 83332010507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332010508 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 83332010509 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332010510 DNA-binding interface [nucleotide binding]; DNA binding site 83332010511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 83332010512 transposase; Provisional; Region: PRK06526 83332010513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010514 Walker B motif; other site 83332010515 Transposase, Mutator family; Region: Transposase_mut; pfam00872 83332010516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 83332010517 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 83332010518 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 83332010519 FIC domain binding interface [polypeptide binding]; other site 83332010520 DNA polymerase III subunit delta'; Validated; Region: PRK07940 83332010521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010522 Walker A motif; other site 83332010523 ATP binding site [chemical binding]; other site 83332010524 Walker B motif; other site 83332010525 arginine finger; other site 83332010526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332010527 dimerization interface [polypeptide binding]; other site 83332010528 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 83332010529 cyclase homology domain; Region: CHD; cd07302 83332010530 nucleotidyl binding site; other site 83332010531 metal binding site [ion binding]; metal-binding site 83332010532 dimer interface [polypeptide binding]; other site 83332010533 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 83332010534 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 83332010535 active site 83332010536 interdomain interaction site; other site 83332010537 putative metal-binding site [ion binding]; other site 83332010538 nucleotide binding site [chemical binding]; other site 83332010539 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 83332010540 domain I; other site 83332010541 DNA binding groove [nucleotide binding] 83332010542 phosphate binding site [ion binding]; other site 83332010543 domain II; other site 83332010544 domain III; other site 83332010545 nucleotide binding site [chemical binding]; other site 83332010546 catalytic site [active] 83332010547 domain IV; other site 83332010548 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 83332010549 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 83332010550 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 83332010551 DNA-binding site [nucleotide binding]; DNA binding site 83332010552 RNA-binding motif; other site 83332010553 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 83332010554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 83332010555 ATP binding site [chemical binding]; other site 83332010556 putative Mg++ binding site [ion binding]; other site 83332010557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 83332010558 nucleotide binding region [chemical binding]; other site 83332010559 ATP-binding site [chemical binding]; other site 83332010560 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 83332010561 PE family; Region: PE; pfam00934 83332010562 PE family; Region: PE; pfam00934 83332010563 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 83332010564 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 83332010565 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 83332010566 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 83332010567 Walker A motif; other site 83332010568 hexamer interface [polypeptide binding]; other site 83332010569 ATP binding site [chemical binding]; other site 83332010570 Walker B motif; other site 83332010571 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 83332010572 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 83332010573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332010574 motif II; other site 83332010575 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 83332010576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332010577 Walker A/P-loop; other site 83332010578 ATP binding site [chemical binding]; other site 83332010579 Q-loop/lid; other site 83332010580 ABC transporter signature motif; other site 83332010581 Walker B; other site 83332010582 D-loop; other site 83332010583 H-loop/switch region; other site 83332010584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332010585 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 83332010586 Walker A/P-loop; other site 83332010587 ATP binding site [chemical binding]; other site 83332010588 Q-loop/lid; other site 83332010589 ABC transporter signature motif; other site 83332010590 Walker B; other site 83332010591 D-loop; other site 83332010592 H-loop/switch region; other site 83332010593 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 83332010594 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 83332010595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010596 dimer interface [polypeptide binding]; other site 83332010597 conserved gate region; other site 83332010598 putative PBP binding loops; other site 83332010599 ABC-ATPase subunit interface; other site 83332010600 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 83332010601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010602 dimer interface [polypeptide binding]; other site 83332010603 conserved gate region; other site 83332010604 putative PBP binding loops; other site 83332010605 ABC-ATPase subunit interface; other site 83332010606 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 83332010607 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 83332010608 acetyl-CoA synthetase; Provisional; Region: PRK00174 83332010609 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 83332010610 active site 83332010611 CoA binding site [chemical binding]; other site 83332010612 acyl-activating enzyme (AAE) consensus motif; other site 83332010613 AMP binding site [chemical binding]; other site 83332010614 acetate binding site [chemical binding]; other site 83332010615 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332010616 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 83332010617 Putative lysophospholipase; Region: Hydrolase_4; cl19140 83332010618 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 83332010619 Colicin V production protein; Region: Colicin_V; pfam02674 83332010620 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 83332010621 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 83332010622 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 83332010623 putative active site [active] 83332010624 putative CoA binding site [chemical binding]; other site 83332010625 nudix motif; other site 83332010626 metal binding site [ion binding]; metal-binding site 83332010627 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 83332010628 catalytic residues [active] 83332010629 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 83332010630 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 83332010631 minor groove reading motif; other site 83332010632 helix-hairpin-helix signature motif; other site 83332010633 substrate binding pocket [chemical binding]; other site 83332010634 active site 83332010635 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 83332010636 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332010637 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332010638 ligand binding site [chemical binding]; other site 83332010639 flexible hinge region; other site 83332010640 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 83332010641 putative switch regulator; other site 83332010642 non-specific DNA interactions [nucleotide binding]; other site 83332010643 DNA binding site [nucleotide binding] 83332010644 sequence specific DNA binding site [nucleotide binding]; other site 83332010645 putative cAMP binding site [chemical binding]; other site 83332010646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332010647 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 83332010648 homotrimer interaction site [polypeptide binding]; other site 83332010649 putative active site [active] 83332010650 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 83332010651 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332010652 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332010653 P loop; other site 83332010654 Nucleotide binding site [chemical binding]; other site 83332010655 DTAP/Switch II; other site 83332010656 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 83332010657 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 83332010658 P loop; other site 83332010659 Nucleotide binding site [chemical binding]; other site 83332010660 DTAP/Switch II; other site 83332010661 Switch I; other site 83332010662 Transcription factor WhiB; Region: Whib; pfam02467 83332010663 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 83332010664 Transglycosylase; Region: Transgly; pfam00912 83332010665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 83332010666 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 83332010667 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 83332010668 putative active site [active] 83332010669 putative metal binding site [ion binding]; other site 83332010670 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 83332010671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010672 catalytic residue [active] 83332010673 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 83332010674 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 83332010675 anti sigma factor interaction site; other site 83332010676 regulatory phosphorylation site [posttranslational modification]; other site 83332010677 Uncharacterized conserved protein [Function unknown]; Region: COG1610 83332010678 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 83332010679 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 83332010680 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 83332010681 MoxR-like ATPases [General function prediction only]; Region: COG0714 83332010682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010683 Walker A motif; other site 83332010684 ATP binding site [chemical binding]; other site 83332010685 Walker B motif; other site 83332010686 arginine finger; other site 83332010687 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 83332010688 Protein of unknown function DUF58; Region: DUF58; pfam01882 83332010689 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 83332010690 Predicted membrane protein/domain [Function unknown]; Region: COG1714 83332010691 glycerol kinase; Provisional; Region: glpK; PRK00047 83332010692 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 83332010693 N- and C-terminal domain interface [polypeptide binding]; other site 83332010694 active site 83332010695 MgATP binding site [chemical binding]; other site 83332010696 catalytic site [active] 83332010697 metal binding site [ion binding]; metal-binding site 83332010698 putative homotetramer interface [polypeptide binding]; other site 83332010699 glycerol binding site [chemical binding]; other site 83332010700 homodimer interface [polypeptide binding]; other site 83332010701 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 83332010702 putative active site [active] 83332010703 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 83332010704 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 83332010705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010706 S-adenosylmethionine binding site [chemical binding]; other site 83332010707 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 83332010708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010709 catalytic residue [active] 83332010710 Uncharacterized conserved protein [Function unknown]; Region: COG4301 83332010711 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 83332010712 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 83332010713 putative active site [active] 83332010714 putative dimer interface [polypeptide binding]; other site 83332010715 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 83332010716 DinB superfamily; Region: DinB_2; pfam12867 83332010717 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 83332010718 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 83332010719 PknH-like extracellular domain; Region: PknH_C; pfam14032 83332010720 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 83332010721 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 83332010722 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 83332010723 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 83332010724 aspartate kinase; Reviewed; Region: PRK06635 83332010725 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 83332010726 putative nucleotide binding site [chemical binding]; other site 83332010727 putative catalytic residues [active] 83332010728 putative Mg ion binding site [ion binding]; other site 83332010729 putative aspartate binding site [chemical binding]; other site 83332010730 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 83332010731 putative allosteric regulatory site; other site 83332010732 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 83332010733 2-isopropylmalate synthase; Validated; Region: PRK03739 83332010734 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 83332010735 active site 83332010736 catalytic residues [active] 83332010737 metal binding site [ion binding]; metal-binding site 83332010738 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 83332010739 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 83332010740 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 83332010741 active site 83332010742 catalytic site [active] 83332010743 substrate binding site [chemical binding]; other site 83332010744 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 83332010745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 83332010746 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 83332010747 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 83332010748 catalytic triad [active] 83332010749 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 83332010750 putative active site [active] 83332010751 recombination protein RecR; Reviewed; Region: recR; PRK00076 83332010752 Helix-hairpin-helix motif; Region: HHH; pfam00633 83332010753 RecR protein; Region: RecR; pfam02132 83332010754 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 83332010755 putative active site [active] 83332010756 putative metal-binding site [ion binding]; other site 83332010757 tetramer interface [polypeptide binding]; other site 83332010758 hypothetical protein; Validated; Region: PRK00153 83332010759 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 83332010760 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 83332010761 active site 83332010762 metal binding site [ion binding]; metal-binding site 83332010763 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 83332010764 hydrophobic ligand binding site; other site 83332010765 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332010766 FAD binding domain; Region: FAD_binding_4; cl19922 83332010767 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 83332010768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010769 S-adenosylmethionine binding site [chemical binding]; other site 83332010770 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 83332010771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332010772 Walker A motif; other site 83332010773 ATP binding site [chemical binding]; other site 83332010774 Walker B motif; other site 83332010775 arginine finger; other site 83332010776 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 83332010777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 83332010778 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 83332010779 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010780 catalytic residue [active] 83332010781 Cutinase; Region: Cutinase; pfam01083 83332010782 Cutinase; Region: Cutinase; pfam01083 83332010783 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 83332010784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332010785 NAD(P) binding site [chemical binding]; other site 83332010786 active site 83332010787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 83332010788 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 83332010789 putative NAD(P) binding site [chemical binding]; other site 83332010790 catalytic Zn binding site [ion binding]; other site 83332010791 Uncharacterized conserved protein [Function unknown]; Region: COG3349 83332010792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332010793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 83332010794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 83332010795 putative substrate translocation pore; other site 83332010796 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 83332010797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 83332010798 ligand binding site [chemical binding]; other site 83332010799 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 83332010800 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 83332010801 active site 83332010802 nucleophile elbow; other site 83332010803 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 83332010804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 83332010805 FeS/SAM binding site; other site 83332010806 Methyltransferase domain; Region: Methyltransf_31; pfam13847 83332010807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332010808 S-adenosylmethionine binding site [chemical binding]; other site 83332010809 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 83332010810 nucleotide binding site [chemical binding]; other site 83332010811 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 83332010812 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 83332010813 active site 83332010814 DNA binding site [nucleotide binding] 83332010815 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 83332010816 DNA binding site [nucleotide binding] 83332010817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 83332010818 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 83332010819 nudix motif; other site 83332010820 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332010821 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332010822 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 83332010823 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 83332010824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332010825 Uncharacterized conserved protein [Function unknown]; Region: COG2966 83332010826 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 83332010827 Uncharacterized conserved protein [Function unknown]; Region: COG3610 83332010828 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010829 PPE family; Region: PPE; pfam00823 83332010830 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332010831 PPE family; Region: PPE; pfam00823 83332010832 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 83332010833 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 83332010834 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332010835 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332010836 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 83332010837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 83332010838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 83332010839 Soluble P-type ATPase [General function prediction only]; Region: COG4087 83332010840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 83332010841 dimerization interface [polypeptide binding]; other site 83332010842 putative DNA binding site [nucleotide binding]; other site 83332010843 putative Zn2+ binding site [ion binding]; other site 83332010844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 83332010845 PIN domain; Region: PIN_3; pfam13470 83332010846 DNA binding domain, excisionase family; Region: excise; TIGR01764 83332010847 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 83332010848 DNA binding site [nucleotide binding] 83332010849 active site 83332010850 Int/Topo IB signature motif; other site 83332010851 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 83332010852 nucleoside/Zn binding site; other site 83332010853 dimer interface [polypeptide binding]; other site 83332010854 catalytic motif [active] 83332010855 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 83332010856 prephenate dehydrogenase; Validated; Region: PRK06545 83332010857 prephenate dehydrogenase; Validated; Region: PRK08507 83332010858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 83332010859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010860 dimer interface [polypeptide binding]; other site 83332010861 conserved gate region; other site 83332010862 putative PBP binding loops; other site 83332010863 ABC-ATPase subunit interface; other site 83332010864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 83332010865 dimer interface [polypeptide binding]; other site 83332010866 conserved gate region; other site 83332010867 putative PBP binding loops; other site 83332010868 ABC-ATPase subunit interface; other site 83332010869 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 83332010870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 83332010871 Walker A/P-loop; other site 83332010872 ATP binding site [chemical binding]; other site 83332010873 Q-loop/lid; other site 83332010874 ABC transporter signature motif; other site 83332010875 Walker B; other site 83332010876 D-loop; other site 83332010877 H-loop/switch region; other site 83332010878 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 83332010879 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 83332010880 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 83332010881 Phosphotransferase enzyme family; Region: APH; pfam01636 83332010882 putative active site [active] 83332010883 putative substrate binding site [chemical binding]; other site 83332010884 ATP binding site [chemical binding]; other site 83332010885 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 83332010886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 83332010887 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 83332010888 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 83332010889 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 83332010890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 83332010891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 83332010892 dimerization interface [polypeptide binding]; other site 83332010893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 83332010894 dimer interface [polypeptide binding]; other site 83332010895 phosphorylation site [posttranslational modification] 83332010896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 83332010897 ATP binding site [chemical binding]; other site 83332010898 Mg2+ binding site [ion binding]; other site 83332010899 G-X-G motif; other site 83332010900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 83332010901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 83332010902 active site 83332010903 phosphorylation site [posttranslational modification] 83332010904 intermolecular recognition site; other site 83332010905 dimerization interface [polypeptide binding]; other site 83332010906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 83332010907 DNA binding site [nucleotide binding] 83332010908 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 83332010909 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 83332010910 SnoaL-like domain; Region: SnoaL_2; pfam12680 83332010911 putative aminotransferase; Provisional; Region: PRK03321 83332010912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 83332010913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 83332010914 homodimer interface [polypeptide binding]; other site 83332010915 catalytic residue [active] 83332010916 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 83332010917 TIGR03086 family protein; Region: TIGR03086 83332010918 enoyl-CoA hydratase; Provisional; Region: PRK06142 83332010919 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 83332010920 substrate binding site [chemical binding]; other site 83332010921 oxyanion hole (OAH) forming residues; other site 83332010922 trimer interface [polypeptide binding]; other site 83332010923 Beta-lactamase; Region: Beta-lactamase; pfam00144 83332010924 Domain of unknown function (DUF222); Region: DUF222; pfam02720 83332010925 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 83332010926 active site 83332010927 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 83332010928 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 83332010929 NAD(P) binding site [chemical binding]; other site 83332010930 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 83332010931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 83332010932 catalytic residue [active] 83332010933 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 83332010934 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 83332010935 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 83332010936 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 83332010937 Walker A/P-loop; other site 83332010938 ATP binding site [chemical binding]; other site 83332010939 Q-loop/lid; other site 83332010940 ABC transporter signature motif; other site 83332010941 Walker B; other site 83332010942 D-loop; other site 83332010943 H-loop/switch region; other site 83332010944 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332010945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332010946 active site 83332010947 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 83332010948 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 83332010949 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 83332010950 NAD binding site [chemical binding]; other site 83332010951 substrate binding site [chemical binding]; other site 83332010952 active site 83332010953 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 83332010954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332010955 active site 83332010956 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 83332010957 Peptidase family M23; Region: Peptidase_M23; pfam01551 83332010958 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 83332010959 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 83332010960 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 83332010961 Predicted membrane protein [Function unknown]; Region: COG2246 83332010962 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 83332010963 FAD binding domain; Region: FAD_binding_4; pfam01565 83332010964 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 83332010965 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 83332010966 classical (c) SDRs; Region: SDR_c; cd05233 83332010967 NAD(P) binding site [chemical binding]; other site 83332010968 active site 83332010969 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 83332010970 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 83332010971 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010972 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 83332010973 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010974 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 83332010975 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 83332010976 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 83332010977 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 83332010978 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 83332010979 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 83332010980 FAD binding site [chemical binding]; other site 83332010981 substrate binding site [chemical binding]; other site 83332010982 catalytic residues [active] 83332010983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 83332010984 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 83332010985 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 83332010986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 83332010987 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 83332010988 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 83332010989 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 83332010990 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332010991 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332010992 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332010993 active site 83332010994 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 83332010995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 83332010996 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 83332010997 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 83332010998 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332010999 acyl-activating enzyme (AAE) consensus motif; other site 83332011000 active site 83332011001 Cutinase; Region: Cutinase; pfam01083 83332011002 Predicted esterase [General function prediction only]; Region: COG0627 83332011003 Predicted esterase [General function prediction only]; Region: COG0627 83332011004 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 83332011005 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 83332011006 putative active site [active] 83332011007 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 83332011008 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 83332011009 active site 83332011010 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 83332011011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 83332011012 active site 83332011013 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 83332011014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332011015 UDP-galactopyranose mutase; Region: GLF; pfam03275 83332011016 poly-U binding splicing factor, half-pint family; Region: half-pint; TIGR01645 83332011017 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 83332011018 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 83332011019 amidase catalytic site [active] 83332011020 Zn binding residues [ion binding]; other site 83332011021 substrate binding site [chemical binding]; other site 83332011022 LGFP repeat; Region: LGFP; pfam08310 83332011023 PE family; Region: PE; pfam00934 83332011024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 83332011025 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 83332011026 active site 83332011027 motif I; other site 83332011028 motif II; other site 83332011029 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 83332011030 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332011031 putative acyl-acceptor binding pocket; other site 83332011032 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332011033 putative acyl-acceptor binding pocket; other site 83332011034 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 83332011035 putative acyl-acceptor binding pocket; other site 83332011036 Aminoglycoside phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: Aph; COG3231 83332011037 Phosphotransferase enzyme family; Region: APH; pfam01636 83332011038 active site 83332011039 ATP binding site [chemical binding]; other site 83332011040 substrate binding site [chemical binding]; other site 83332011041 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 83332011042 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 83332011043 iron-sulfur cluster [ion binding]; other site 83332011044 [2Fe-2S] cluster binding site [ion binding]; other site 83332011045 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 83332011046 Condensation domain; Region: Condensation; cl19241 83332011047 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 83332011048 PE-PPE domain; Region: PE-PPE; pfam08237 83332011049 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 83332011050 MMPL family; Region: MMPL; pfam03176 83332011051 MMPL family; Region: MMPL; pfam03176 83332011052 Condensation domain; Region: Condensation; cl19241 83332011053 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 83332011054 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 83332011055 active site 83332011056 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 83332011057 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 83332011058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 83332011059 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 83332011060 Enoylreductase; Region: PKS_ER; smart00829 83332011061 NAD(P) binding site [chemical binding]; other site 83332011062 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 83332011063 short chain dehydrogenase; Region: adh_short; pfam00106 83332011064 putative NADP binding site [chemical binding]; other site 83332011065 active site 83332011066 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 83332011067 acyl-CoA synthetase; Validated; Region: PRK05850 83332011068 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 83332011069 acyl-activating enzyme (AAE) consensus motif; other site 83332011070 active site 83332011071 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 83332011072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 83332011073 Probable transposase; Region: OrfB_IS605; pfam01385 83332011074 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 83332011075 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 83332011076 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 83332011077 catalytic residues [active] 83332011078 catalytic nucleophile [active] 83332011079 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 83332011080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332011081 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 83332011082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332011083 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 83332011084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 83332011085 S-adenosylmethionine binding site [chemical binding]; other site 83332011086 Cupin domain; Region: Cupin_2; cl17218 83332011087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 83332011088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 83332011089 seryl-tRNA synthetase; Provisional; Region: PRK05431 83332011090 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 83332011091 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 83332011092 dimer interface [polypeptide binding]; other site 83332011093 active site 83332011094 motif 1; other site 83332011095 motif 2; other site 83332011096 motif 3; other site 83332011097 Septum formation; Region: Septum_form; pfam13845 83332011098 Septum formation; Region: Septum_form; pfam13845 83332011099 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 83332011100 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 83332011101 catalytic core [active] 83332011102 prephenate dehydratase; Provisional; Region: PRK11898 83332011103 Prephenate dehydratase; Region: PDT; pfam00800 83332011104 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 83332011105 putative L-Phe binding site [chemical binding]; other site 83332011106 Transcriptional regulator [Transcription]; Region: LytR; COG1316 83332011107 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 83332011108 Ferritin-like domain; Region: Ferritin; pfam00210 83332011109 ferroxidase diiron center [ion binding]; other site 83332011110 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 83332011111 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 83332011112 putative active site [active] 83332011113 catalytic site [active] 83332011114 putative metal binding site [ion binding]; other site 83332011115 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 83332011116 Transposase; Region: DEDD_Tnp_IS110; pfam01548 83332011117 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 83332011118 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 83332011119 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 83332011120 Predicted membrane protein [Function unknown]; Region: COG2119 83332011121 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 83332011122 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 83332011123 Fimbrial protein; Region: Fimbrial; cl01416 83332011124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 83332011125 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 83332011126 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 83332011127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 83332011128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 83332011129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 83332011130 hypothetical protein; Provisional; Region: PRK07945 83332011131 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 83332011132 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 83332011133 active site 83332011134 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 83332011135 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 83332011136 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 83332011137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 83332011138 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 83332011139 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 83332011140 active site 83332011141 dimer interface [polypeptide binding]; other site 83332011142 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 83332011143 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 83332011144 active site 83332011145 FMN binding site [chemical binding]; other site 83332011146 substrate binding site [chemical binding]; other site 83332011147 3Fe-4S cluster binding site [ion binding]; other site 83332011148 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 83332011149 domain interface; other site 83332011150 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 83332011151 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332011152 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332011153 Transcription factor WhiB; Region: Whib; pfam02467 83332011154 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 83332011155 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 83332011156 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 83332011157 EspG family; Region: ESX-1_EspG; pfam14011 83332011158 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332011159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332011160 Walker A motif; other site 83332011161 ATP binding site [chemical binding]; other site 83332011162 Walker B motif; other site 83332011163 arginine finger; other site 83332011164 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332011165 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332011166 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011167 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332011168 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011169 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332011171 Walker A motif; other site 83332011172 ATP binding site [chemical binding]; other site 83332011173 PE family; Region: PE; pfam00934 83332011174 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 83332011175 PPE family; Region: PPE; pfam00823 83332011176 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 83332011177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332011178 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332011179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332011180 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332011181 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 83332011182 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 83332011183 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332011184 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332011185 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332011186 active site 83332011187 catalytic residues [active] 83332011188 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 83332011189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 83332011190 Walker A motif; other site 83332011191 ATP binding site [chemical binding]; other site 83332011192 Walker B motif; other site 83332011193 arginine finger; other site 83332011194 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 83332011195 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 83332011196 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 83332011197 active site 83332011198 catalytic residues [active] 83332011199 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 83332011200 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 83332011201 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 83332011202 EspG family; Region: ESX-1_EspG; pfam14011 83332011203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332011204 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 83332011205 PPE family; Region: PPE; pfam00823 83332011206 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 83332011207 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011208 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 83332011209 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011210 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 83332011211 Protein of unknown function (DUF690); Region: DUF690; pfam05108 83332011212 SLT domain proteins [General function prediction only]; Region: COG3953 83332011213 catalytic residue [active] 83332011214 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 83332011215 Immunity protein 37; Region: Imm37; pfam15598 83332011216 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 83332011217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 83332011218 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 83332011219 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 83332011220 active site 83332011221 NTP binding site [chemical binding]; other site 83332011222 metal binding triad [ion binding]; metal-binding site 83332011223 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 83332011224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 83332011225 Zn2+ binding site [ion binding]; other site 83332011226 Mg2+ binding site [ion binding]; other site 83332011227 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 83332011228 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 83332011229 active site 83332011230 Ap6A binding site [chemical binding]; other site 83332011231 nudix motif; other site 83332011232 metal binding site [ion binding]; metal-binding site 83332011233 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 83332011234 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 83332011235 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 83332011236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 83332011237 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 83332011238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 83332011239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 83332011240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 83332011241 catalytic residues [active] 83332011242 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 83332011243 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 83332011244 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 83332011245 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 83332011246 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 83332011247 active site 83332011248 metal binding site [ion binding]; metal-binding site 83332011249 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 83332011250 ParB-like nuclease domain; Region: ParBc; pfam02195 83332011251 KorB domain; Region: KorB; pfam08535 83332011252 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 83332011253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 83332011254 P-loop; other site 83332011255 Magnesium ion binding site [ion binding]; other site 83332011256 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 83332011257 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 83332011258 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 83332011259 G-X-X-G motif; other site 83332011260 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 83332011261 RxxxH motif; other site 83332011262 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 83332011263 Uncharacterized conserved protein [Function unknown]; Region: COG0759 83332011264 ribonuclease P; Reviewed; Region: rnpA; PRK00588 83332011265 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399