-- dump date 20140619_154225 -- class Genbank::misc_feature -- table misc_feature_note -- id note 707235000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 707235000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235000003 Walker A motif; other site 707235000004 ATP binding site [chemical binding]; other site 707235000005 Walker B motif; other site 707235000006 arginine finger; other site 707235000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 707235000008 DnaA box-binding interface [nucleotide binding]; other site 707235000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 707235000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 707235000011 putative DNA binding surface [nucleotide binding]; other site 707235000012 dimer interface [polypeptide binding]; other site 707235000013 beta-clamp/clamp loader binding surface; other site 707235000014 beta-clamp/translesion DNA polymerase binding surface; other site 707235000015 recF protein; Region: recf; TIGR00611 707235000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 707235000017 Walker A/P-loop; other site 707235000018 ATP binding site [chemical binding]; other site 707235000019 Q-loop/lid; other site 707235000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235000021 ABC transporter signature motif; other site 707235000022 Walker B; other site 707235000023 D-loop; other site 707235000024 H-loop/switch region; other site 707235000025 hypothetical protein; Provisional; Region: PRK03195 707235000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 707235000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235000028 Mg2+ binding site [ion binding]; other site 707235000029 G-X-G motif; other site 707235000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 707235000031 anchoring element; other site 707235000032 dimer interface [polypeptide binding]; other site 707235000033 ATP binding site [chemical binding]; other site 707235000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 707235000035 active site 707235000036 putative metal-binding site [ion binding]; other site 707235000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 707235000038 DNA gyrase subunit A; Validated; Region: PRK05560 707235000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 707235000040 CAP-like domain; other site 707235000041 active site 707235000042 primary dimer interface [polypeptide binding]; other site 707235000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707235000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 707235000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 707235000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 707235000052 active site 707235000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 707235000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 707235000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 707235000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 707235000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 707235000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 707235000059 glutamine binding [chemical binding]; other site 707235000060 catalytic triad [active] 707235000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235000063 active site 707235000064 ATP binding site [chemical binding]; other site 707235000065 substrate binding site [chemical binding]; other site 707235000066 activation loop (A-loop); other site 707235000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 707235000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 707235000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 707235000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 707235000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 707235000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235000074 active site 707235000075 ATP binding site [chemical binding]; other site 707235000076 substrate binding site [chemical binding]; other site 707235000077 activation loop (A-loop); other site 707235000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 707235000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 707235000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 707235000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 707235000082 active site 707235000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235000085 phosphopeptide binding site; other site 707235000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 707235000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235000089 phosphopeptide binding site; other site 707235000090 Nitronate monooxygenase; Region: NMO; pfam03060 707235000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 707235000092 FMN binding site [chemical binding]; other site 707235000093 substrate binding site [chemical binding]; other site 707235000094 putative catalytic residue [active] 707235000095 Transcription factor WhiB; Region: Whib; pfam02467 707235000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235000098 non-specific DNA binding site [nucleotide binding]; other site 707235000099 salt bridge; other site 707235000100 sequence-specific DNA binding site [nucleotide binding]; other site 707235000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707235000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 707235000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 707235000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 707235000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 707235000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 707235000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 707235000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 707235000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 707235000110 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 707235000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235000112 catalytic residue [active] 707235000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 707235000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 707235000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 707235000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235000117 acyl-activating enzyme (AAE) consensus motif; other site 707235000118 active site 707235000119 TIGR03084 family protein; Region: TIGR03084 707235000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 707235000121 Wyosine base formation; Region: Wyosine_form; pfam08608 707235000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 707235000123 hypothetical protein; Validated; Region: PRK00228 707235000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 707235000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 707235000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235000127 active site 707235000128 HIGH motif; other site 707235000129 nucleotide binding site [chemical binding]; other site 707235000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 707235000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235000133 active site 707235000134 KMSKS motif; other site 707235000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 707235000136 tRNA binding surface [nucleotide binding]; other site 707235000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235000138 MarR family; Region: MarR; pfam01047 707235000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 707235000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235000141 DNA-binding site [nucleotide binding]; DNA binding site 707235000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 707235000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 707235000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 707235000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 707235000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 707235000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 707235000150 Transglycosylase; Region: Transgly; pfam00912 707235000151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 707235000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 707235000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 707235000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 707235000155 conserved cys residue [active] 707235000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 707235000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 707235000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 707235000159 dimer interface [polypeptide binding]; other site 707235000160 ssDNA binding site [nucleotide binding]; other site 707235000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 707235000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 707235000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 707235000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 707235000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 707235000166 replicative DNA helicase; Validated; Region: PRK07773 707235000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 707235000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 707235000169 Walker A motif; other site 707235000170 ATP binding site [chemical binding]; other site 707235000171 Walker B motif; other site 707235000172 DNA binding loops [nucleotide binding] 707235000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 707235000174 protein-splicing catalytic site; other site 707235000175 thioester formation/cholesterol transfer; other site 707235000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 707235000177 protein-splicing catalytic site; other site 707235000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 707235000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 707235000180 ADP-ribose binding site [chemical binding]; other site 707235000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 707235000182 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 707235000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 707235000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235000185 FAD binding domain; Region: FAD_binding_4; pfam01565 707235000186 Berberine and berberine like; Region: BBE; pfam08031 707235000187 hypothetical protein; Provisional; Region: PRK12438 707235000188 hypothetical protein; Validated; Region: PRK00068 707235000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 707235000190 homotetrameric interface [polypeptide binding]; other site 707235000191 putative active site [active] 707235000192 metal binding site [ion binding]; metal-binding site 707235000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 707235000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 707235000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000197 short chain dehydrogenase; Provisional; Region: PRK06197 707235000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 707235000199 putative NAD(P) binding site [chemical binding]; other site 707235000200 active site 707235000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 707235000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 707235000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 707235000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 707235000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 707235000206 dimer interface [polypeptide binding]; other site 707235000207 active site 707235000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 707235000209 folate binding site [chemical binding]; other site 707235000210 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 707235000211 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 707235000212 putative NTP binding site [chemical binding]; other site 707235000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 707235000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 707235000215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707235000216 Walker A/P-loop; other site 707235000217 ATP binding site [chemical binding]; other site 707235000218 Q-loop/lid; other site 707235000219 ABC transporter signature motif; other site 707235000220 Walker B; other site 707235000221 D-loop; other site 707235000222 H-loop/switch region; other site 707235000223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235000224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235000225 ligand binding site [chemical binding]; other site 707235000226 flexible hinge region; other site 707235000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 707235000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 707235000229 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 707235000230 active site 707235000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 707235000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235000234 homodimer interface [polypeptide binding]; other site 707235000235 catalytic residue [active] 707235000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 707235000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235000241 dimerization interface [polypeptide binding]; other site 707235000242 putative DNA binding site [nucleotide binding]; other site 707235000243 putative Zn2+ binding site [ion binding]; other site 707235000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 707235000245 hydrogenase 4 subunit B; Validated; Region: PRK06521 707235000246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 707235000247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 707235000248 NADH dehydrogenase; Region: NADHdh; cl00469 707235000249 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 707235000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 707235000251 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 707235000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 707235000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 707235000254 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 707235000255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 707235000256 putative hydrophobic ligand binding site [chemical binding]; other site 707235000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000258 S-adenosylmethionine binding site [chemical binding]; other site 707235000259 Predicted membrane protein [Function unknown]; Region: COG3305 707235000260 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 707235000261 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 707235000262 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 707235000263 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 707235000264 metal-binding site [ion binding] 707235000265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235000266 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235000267 Predicted integral membrane protein [Function unknown]; Region: COG5660 707235000268 Putative zinc-finger; Region: zf-HC2; pfam13490 707235000269 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235000270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235000271 active site 707235000272 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235000273 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000274 PPE family; Region: PPE; pfam00823 707235000275 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 707235000276 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 707235000277 FcoT-like thioesterase domain; Region: FcoT; pfam10862 707235000278 acyl-CoA synthetase; Validated; Region: PRK05857 707235000279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000280 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 707235000281 acyl-activating enzyme (AAE) consensus motif; other site 707235000282 acyl-activating enzyme (AAE) consensus motif; other site 707235000283 AMP binding site [chemical binding]; other site 707235000284 active site 707235000285 CoA binding site [chemical binding]; other site 707235000286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235000287 AMP-binding enzyme; Region: AMP-binding; pfam00501 707235000288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000290 acyl-activating enzyme (AAE) consensus motif; other site 707235000291 acyl-activating enzyme (AAE) consensus motif; other site 707235000292 active site 707235000293 AMP binding site [chemical binding]; other site 707235000294 CoA binding site [chemical binding]; other site 707235000295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235000296 Condensation domain; Region: Condensation; pfam00668 707235000297 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235000298 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 707235000299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 707235000300 acyl-activating enzyme (AAE) consensus motif; other site 707235000301 AMP binding site [chemical binding]; other site 707235000302 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235000303 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 707235000304 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 707235000305 putative NAD(P) binding site [chemical binding]; other site 707235000306 active site 707235000307 putative substrate binding site [chemical binding]; other site 707235000308 Predicted membrane protein [Function unknown]; Region: COG3336 707235000309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 707235000310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 707235000311 metal-binding site [ion binding] 707235000312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235000313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235000314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235000315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235000316 ligand binding site [chemical binding]; other site 707235000317 flexible hinge region; other site 707235000318 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 707235000319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 707235000320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 707235000321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 707235000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235000323 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 707235000324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235000325 motif II; other site 707235000326 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 707235000327 PE family; Region: PE; pfam00934 707235000328 Rhomboid family; Region: Rhomboid; pfam01694 707235000329 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 707235000330 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 707235000331 active site 707235000332 catalytic triad [active] 707235000333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235000334 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 707235000335 NADP-binding site; other site 707235000336 homotetramer interface [polypeptide binding]; other site 707235000337 substrate binding site [chemical binding]; other site 707235000338 homodimer interface [polypeptide binding]; other site 707235000339 active site 707235000340 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 707235000341 dimer interface [polypeptide binding]; other site 707235000342 active site 707235000343 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 707235000344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235000345 active site 707235000346 motif I; other site 707235000347 motif II; other site 707235000348 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 707235000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 707235000350 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 707235000351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 707235000352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 707235000353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 707235000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 707235000355 dimerization interface [polypeptide binding]; other site 707235000356 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 707235000357 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 707235000358 PYR/PP interface [polypeptide binding]; other site 707235000359 dimer interface [polypeptide binding]; other site 707235000360 TPP binding site [chemical binding]; other site 707235000361 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 707235000362 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 707235000363 TPP-binding site; other site 707235000364 dimer interface [polypeptide binding]; other site 707235000365 acyl-CoA synthetase; Validated; Region: PRK05852 707235000366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000367 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 707235000368 acyl-activating enzyme (AAE) consensus motif; other site 707235000369 acyl-activating enzyme (AAE) consensus motif; other site 707235000370 putative AMP binding site [chemical binding]; other site 707235000371 putative active site [active] 707235000372 putative CoA binding site [chemical binding]; other site 707235000373 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 707235000374 elongation factor G; Reviewed; Region: PRK12740 707235000375 G1 box; other site 707235000376 putative GEF interaction site [polypeptide binding]; other site 707235000377 GTP/Mg2+ binding site [chemical binding]; other site 707235000378 Switch I region; other site 707235000379 G2 box; other site 707235000380 G3 box; other site 707235000381 Switch II region; other site 707235000382 G4 box; other site 707235000383 G5 box; other site 707235000384 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 707235000385 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 707235000386 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 707235000387 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 707235000388 PE family; Region: PE; pfam00934 707235000389 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 707235000390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707235000391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 707235000392 trehalose synthase; Region: treS_nterm; TIGR02456 707235000393 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 707235000394 active site 707235000395 catalytic site [active] 707235000396 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 707235000397 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 707235000398 Predicted membrane protein [Function unknown]; Region: COG3619 707235000399 Predicted esterase [General function prediction only]; Region: COG0627 707235000400 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 707235000401 putative active site [active] 707235000402 putative catalytic site [active] 707235000403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235000404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235000405 active site 707235000406 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 707235000407 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235000408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 707235000409 Coenzyme A binding pocket [chemical binding]; other site 707235000410 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235000411 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 707235000412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000414 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235000415 Cytochrome P450; Region: p450; cl12078 707235000416 methionine sulfoxide reductase A; Provisional; Region: PRK14054 707235000417 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235000418 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 707235000419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235000420 NAD(P) binding site [chemical binding]; other site 707235000421 active site 707235000422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 707235000423 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 707235000424 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 707235000425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707235000426 minor groove reading motif; other site 707235000427 helix-hairpin-helix signature motif; other site 707235000428 active site 707235000429 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 707235000430 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 707235000431 Cl- selectivity filter; other site 707235000432 Cl- binding residues [ion binding]; other site 707235000433 pore gating glutamate residue; other site 707235000434 dimer interface [polypeptide binding]; other site 707235000435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000437 Leucine carboxyl methyltransferase; Region: LCM; cl01306 707235000438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235000439 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235000440 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 707235000441 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 707235000442 NAD(P) binding site [chemical binding]; other site 707235000443 catalytic residues [active] 707235000444 short chain dehydrogenase; Provisional; Region: PRK07791 707235000445 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 707235000446 NAD binding site [chemical binding]; other site 707235000447 homodimer interface [polypeptide binding]; other site 707235000448 active site 707235000449 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 707235000450 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 707235000451 NAD(P) binding site [chemical binding]; other site 707235000452 PE family; Region: PE; pfam00934 707235000453 PE-PPE domain; Region: PE-PPE; pfam08237 707235000454 PE-PPE domain; Region: PE-PPE; pfam08237 707235000455 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 707235000456 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 707235000457 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 707235000458 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 707235000459 FAD binding site [chemical binding]; other site 707235000460 substrate binding site [chemical binding]; other site 707235000461 catalytic base [active] 707235000462 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 707235000463 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 707235000464 ligand binding site [chemical binding]; other site 707235000465 homodimer interface [polypeptide binding]; other site 707235000466 NAD(P) binding site [chemical binding]; other site 707235000467 trimer interface B [polypeptide binding]; other site 707235000468 trimer interface A [polypeptide binding]; other site 707235000469 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 707235000470 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 707235000471 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 707235000472 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 707235000473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000475 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 707235000476 PE family; Region: PE; pfam00934 707235000477 PE-PPE domain; Region: PE-PPE; pfam08237 707235000478 PE family; Region: PE; pfam00934 707235000479 PE-PPE domain; Region: PE-PPE; pfam08237 707235000480 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 707235000481 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 707235000482 NAD(P) binding site [chemical binding]; other site 707235000483 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 707235000484 active site 707235000485 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 707235000486 putative hydrophobic ligand binding site [chemical binding]; other site 707235000487 Transcriptional regulators [Transcription]; Region: GntR; COG1802 707235000488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235000489 DNA-binding site [nucleotide binding]; DNA binding site 707235000490 FCD domain; Region: FCD; pfam07729 707235000491 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 707235000492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000493 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 707235000494 acyl-activating enzyme (AAE) consensus motif; other site 707235000495 acyl-activating enzyme (AAE) consensus motif; other site 707235000496 putative AMP binding site [chemical binding]; other site 707235000497 putative active site [active] 707235000498 putative CoA binding site [chemical binding]; other site 707235000499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235000500 Permease; Region: Permease; pfam02405 707235000501 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235000502 Permease; Region: Permease; pfam02405 707235000503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000504 mce related protein; Region: MCE; pfam02470 707235000505 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000507 mce related protein; Region: MCE; pfam02470 707235000508 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235000509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000510 mce related protein; Region: MCE; pfam02470 707235000511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000512 mce related protein; Region: MCE; pfam02470 707235000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000514 mce related protein; Region: MCE; pfam02470 707235000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235000516 mce related protein; Region: MCE; pfam02470 707235000517 RDD family; Region: RDD; pfam06271 707235000518 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 707235000519 Predicted membrane protein [Function unknown]; Region: COG1511 707235000520 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 707235000521 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 707235000522 Pirin-related protein [General function prediction only]; Region: COG1741 707235000523 Pirin; Region: Pirin; pfam02678 707235000524 RNA polymerase factor sigma-70; Validated; Region: PRK08241 707235000525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235000526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235000527 DNA binding residues [nucleotide binding] 707235000528 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235000529 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 707235000530 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235000531 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 707235000532 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 707235000533 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 707235000534 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 707235000535 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 707235000536 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 707235000537 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 707235000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000539 S-adenosylmethionine binding site [chemical binding]; other site 707235000540 SPW repeat; Region: SPW; pfam03779 707235000541 SPW repeat; Region: SPW; pfam03779 707235000542 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 707235000543 6-phosphogluconate dehydratase; Region: edd; TIGR01196 707235000544 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 707235000545 putative homodimer interface [polypeptide binding]; other site 707235000546 putative homotetramer interface [polypeptide binding]; other site 707235000547 putative allosteric switch controlling residues; other site 707235000548 putative metal binding site [ion binding]; other site 707235000549 putative homodimer-homodimer interface [polypeptide binding]; other site 707235000550 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 707235000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235000552 putative substrate translocation pore; other site 707235000553 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 707235000554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 707235000555 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 707235000556 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 707235000557 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 707235000558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235000559 Walker A/P-loop; other site 707235000560 ATP binding site [chemical binding]; other site 707235000561 Q-loop/lid; other site 707235000562 ABC transporter signature motif; other site 707235000563 Walker B; other site 707235000564 D-loop; other site 707235000565 H-loop/switch region; other site 707235000566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 707235000567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235000568 Walker A/P-loop; other site 707235000569 ATP binding site [chemical binding]; other site 707235000570 Q-loop/lid; other site 707235000571 ABC transporter signature motif; other site 707235000572 Walker B; other site 707235000573 D-loop; other site 707235000574 H-loop/switch region; other site 707235000575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235000576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235000577 dimerization interface [polypeptide binding]; other site 707235000578 DNA binding residues [nucleotide binding] 707235000579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000581 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 707235000582 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 707235000583 putative [Fe4-S4] binding site [ion binding]; other site 707235000584 putative molybdopterin cofactor binding site [chemical binding]; other site 707235000585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235000586 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 707235000587 putative molybdopterin cofactor binding site; other site 707235000588 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 707235000589 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 707235000590 active site 707235000591 Zn binding site [ion binding]; other site 707235000592 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235000593 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 707235000594 Predicted integral membrane protein [Function unknown]; Region: COG0392 707235000595 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 707235000596 Domain of unknown function DUF20; Region: UPF0118; pfam01594 707235000597 MMPL family; Region: MMPL; pfam03176 707235000598 MMPL family; Region: MMPL; pfam03176 707235000599 LabA_like proteins; Region: LabA_like; cd06167 707235000600 putative metal binding site [ion binding]; other site 707235000601 Putative methyltransferase; Region: Methyltransf_4; pfam02390 707235000602 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 707235000603 active site 707235000604 substrate-binding site [chemical binding]; other site 707235000605 metal-binding site [ion binding] 707235000606 GTP binding site [chemical binding]; other site 707235000607 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 707235000608 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 707235000609 active site 707235000610 (T/H)XGH motif; other site 707235000611 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 707235000612 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 707235000613 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 707235000614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235000615 FeS/SAM binding site; other site 707235000616 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 707235000617 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000618 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 707235000619 acyl-activating enzyme (AAE) consensus motif; other site 707235000620 acyl-activating enzyme (AAE) consensus motif; other site 707235000621 putative AMP binding site [chemical binding]; other site 707235000622 putative active site [active] 707235000623 putative CoA binding site [chemical binding]; other site 707235000624 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235000625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235000626 active site 707235000627 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 707235000628 putative active site [active] 707235000629 putative catalytic site [active] 707235000630 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 707235000631 active site 2 [active] 707235000632 active site 1 [active] 707235000633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235000634 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235000635 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 707235000636 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 707235000637 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 707235000638 Moco binding site; other site 707235000639 metal coordination site [ion binding]; other site 707235000640 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235000641 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235000642 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235000643 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235000644 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 707235000645 enoyl-CoA hydratase; Provisional; Region: PRK08252 707235000646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235000647 substrate binding site [chemical binding]; other site 707235000648 oxyanion hole (OAH) forming residues; other site 707235000649 trimer interface [polypeptide binding]; other site 707235000650 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 707235000651 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 707235000652 NAD binding site [chemical binding]; other site 707235000653 catalytic residues [active] 707235000654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000655 S-adenosylmethionine binding site [chemical binding]; other site 707235000656 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 707235000657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 707235000658 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 707235000659 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 707235000660 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235000661 putative active site [active] 707235000662 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 707235000663 active site 707235000664 substrate binding pocket [chemical binding]; other site 707235000665 homodimer interaction site [polypeptide binding]; other site 707235000666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235000667 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 707235000668 active site 707235000669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000671 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 707235000672 active site 707235000673 diiron metal binding site [ion binding]; other site 707235000674 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 707235000675 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 707235000676 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 707235000677 NAD(P) binding site [chemical binding]; other site 707235000678 catalytic residues [active] 707235000679 Lipase maturation factor; Region: LMF1; pfam06762 707235000680 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 707235000681 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 707235000682 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 707235000683 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 707235000684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000686 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235000687 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 707235000688 MaoC like domain; Region: MaoC_dehydratas; pfam01575 707235000689 active site 2 [active] 707235000690 active site 1 [active] 707235000691 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 707235000692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235000693 NAD(P) binding site [chemical binding]; other site 707235000694 active site 707235000695 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 707235000696 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235000697 dimer interface [polypeptide binding]; other site 707235000698 active site 707235000699 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 707235000700 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 707235000701 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 707235000702 FAD binding site [chemical binding]; other site 707235000703 substrate binding site [chemical binding]; other site 707235000704 catalytic residues [active] 707235000705 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 707235000706 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 707235000707 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 707235000708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235000709 catalytic loop [active] 707235000710 iron binding site [ion binding]; other site 707235000711 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 707235000712 L-aspartate oxidase; Provisional; Region: PRK06175 707235000713 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 707235000714 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 707235000715 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 707235000716 putative dimer interface [polypeptide binding]; other site 707235000717 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 707235000718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235000719 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 707235000720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 707235000721 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 707235000722 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 707235000723 homotrimer interface [polypeptide binding]; other site 707235000724 Walker A motif; other site 707235000725 GTP binding site [chemical binding]; other site 707235000726 Walker B motif; other site 707235000727 cobyric acid synthase; Provisional; Region: PRK00784 707235000728 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 707235000729 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 707235000730 catalytic triad [active] 707235000731 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000732 PPE family; Region: PPE; pfam00823 707235000733 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 707235000734 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 707235000735 putative active site [active] 707235000736 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 707235000737 putative active site [active] 707235000738 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 707235000739 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 707235000740 active site 707235000741 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 707235000742 DNA binding site [nucleotide binding] 707235000743 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 707235000744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235000745 Coenzyme A binding pocket [chemical binding]; other site 707235000746 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 707235000747 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 707235000748 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 707235000749 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 707235000750 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 707235000751 intersubunit interface [polypeptide binding]; other site 707235000752 5-oxoprolinase; Region: PLN02666 707235000753 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 707235000754 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 707235000755 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 707235000756 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 707235000757 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 707235000758 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 707235000759 nucleotide binding site [chemical binding]; other site 707235000760 acyl-CoA synthetase; Validated; Region: PRK07788 707235000761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235000763 active site 707235000764 CoA binding site [chemical binding]; other site 707235000765 AMP binding site [chemical binding]; other site 707235000766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235000767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235000768 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 707235000769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235000770 FAD binding site [chemical binding]; other site 707235000771 substrate binding site [chemical binding]; other site 707235000772 catalytic base [active] 707235000773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000776 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 707235000777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235000778 Zn binding site [ion binding]; other site 707235000779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 707235000780 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235000781 putative active site [active] 707235000782 PE family; Region: PE; pfam00934 707235000783 PE family; Region: PE; pfam00934 707235000784 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000785 PPE family; Region: PPE; pfam00823 707235000786 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000787 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235000788 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235000789 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 707235000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235000791 Walker A motif; other site 707235000792 ATP binding site [chemical binding]; other site 707235000793 Walker B motif; other site 707235000794 arginine finger; other site 707235000795 Protein of unknown function (DUF690); Region: DUF690; pfam05108 707235000796 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 707235000797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235000798 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 707235000799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235000800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235000801 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000802 PPE family; Region: PPE; pfam00823 707235000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235000804 EspG family; Region: ESX-1_EspG; pfam14011 707235000805 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 707235000806 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235000807 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 707235000808 active site 707235000809 catalytic residues [active] 707235000810 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 707235000811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235000812 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 707235000813 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 707235000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000815 S-adenosylmethionine binding site [chemical binding]; other site 707235000816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 707235000817 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 707235000818 Sulfatase; Region: Sulfatase; cl17466 707235000819 PE family; Region: PE; pfam00934 707235000820 hypothetical protein; Region: PHA01748 707235000821 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235000822 putative active site [active] 707235000823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000825 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 707235000826 protochlorophyllide reductase; Region: PLN00015 707235000827 putative NAD(P) binding site [chemical binding]; other site 707235000828 active site 707235000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000830 PPE family; Region: PPE; pfam00823 707235000831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000837 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000843 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 707235000844 putative FMN binding site [chemical binding]; other site 707235000845 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 707235000846 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 707235000847 active site 707235000848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 707235000849 SnoaL-like domain; Region: SnoaL_4; pfam13577 707235000850 SnoaL-like domain; Region: SnoaL_3; pfam13474 707235000851 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 707235000852 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235000853 nucleotide binding site [chemical binding]; other site 707235000854 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 707235000855 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 707235000856 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 707235000857 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 707235000858 active site 707235000859 catalytic residues [active] 707235000860 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 707235000861 Muconolactone delta-isomerase; Region: MIase; cl01992 707235000862 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 707235000863 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 707235000864 putative active site [active] 707235000865 catalytic site [active] 707235000866 putative metal binding site [ion binding]; other site 707235000867 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 707235000868 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 707235000869 putative substrate binding pocket [chemical binding]; other site 707235000870 AC domain interface; other site 707235000871 catalytic triad [active] 707235000872 AB domain interface; other site 707235000873 interchain disulfide; other site 707235000874 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 707235000875 trimer interface [polypeptide binding]; other site 707235000876 active site 707235000877 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 707235000878 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 707235000879 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 707235000880 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 707235000881 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 707235000882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235000883 dimerization interface [polypeptide binding]; other site 707235000884 putative DNA binding site [nucleotide binding]; other site 707235000885 putative Zn2+ binding site [ion binding]; other site 707235000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 707235000887 active site residue [active] 707235000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235000890 Cytochrome P450; Region: p450; cl12078 707235000891 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 707235000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000893 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 707235000894 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235000895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235000896 S-adenosylmethionine binding site [chemical binding]; other site 707235000897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235000898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235000899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 707235000900 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235000901 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 707235000902 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235000903 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 707235000904 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 707235000905 substrate binding site; other site 707235000906 tetramer interface; other site 707235000907 PE family; Region: PE; pfam00934 707235000908 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235000909 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235000910 active site 707235000911 aminotransferase AlaT; Validated; Region: PRK09265 707235000912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235000913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235000914 homodimer interface [polypeptide binding]; other site 707235000915 catalytic residue [active] 707235000916 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 707235000917 4Fe-4S binding domain; Region: Fer4; pfam00037 707235000918 Cysteine-rich domain; Region: CCG; pfam02754 707235000919 Cysteine-rich domain; Region: CCG; pfam02754 707235000920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235000921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235000922 DNA binding residues [nucleotide binding] 707235000923 dimerization interface [polypeptide binding]; other site 707235000924 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 707235000925 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 707235000926 G1 box; other site 707235000927 GTP/Mg2+ binding site [chemical binding]; other site 707235000928 G2 box; other site 707235000929 Switch I region; other site 707235000930 G3 box; other site 707235000931 Switch II region; other site 707235000932 G4 box; other site 707235000933 G5 box; other site 707235000934 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 707235000935 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 707235000936 G1 box; other site 707235000937 GTP/Mg2+ binding site [chemical binding]; other site 707235000938 G2 box; other site 707235000939 Switch I region; other site 707235000940 G3 box; other site 707235000941 Switch II region; other site 707235000942 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 707235000943 active site 707235000944 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 707235000945 TIGR04255 family protein; Region: sporadTIGR04255 707235000946 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 707235000947 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 707235000948 nucleotide binding site [chemical binding]; other site 707235000949 NEF interaction site [polypeptide binding]; other site 707235000950 SBD interface [polypeptide binding]; other site 707235000951 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 707235000952 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 707235000953 dimer interface [polypeptide binding]; other site 707235000954 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 707235000955 chaperone protein DnaJ; Provisional; Region: PRK14279 707235000956 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 707235000957 HSP70 interaction site [polypeptide binding]; other site 707235000958 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 707235000959 Zn binding sites [ion binding]; other site 707235000960 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 707235000961 dimer interface [polypeptide binding]; other site 707235000962 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 707235000963 DNA binding residues [nucleotide binding] 707235000964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 707235000965 putative dimer interface [polypeptide binding]; other site 707235000966 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000967 PPE family; Region: PPE; pfam00823 707235000968 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235000969 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235000972 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 707235000973 CoenzymeA binding site [chemical binding]; other site 707235000974 subunit interaction site [polypeptide binding]; other site 707235000975 PHB binding site; other site 707235000976 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 707235000977 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 707235000978 GDP-binding site [chemical binding]; other site 707235000979 ACT binding site; other site 707235000980 IMP binding site; other site 707235000981 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 707235000982 Peptidase family M50; Region: Peptidase_M50; pfam02163 707235000983 active site 707235000984 putative substrate binding region [chemical binding]; other site 707235000985 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 707235000986 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 707235000987 MgtE intracellular N domain; Region: MgtE_N; pfam03448 707235000988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 707235000989 Divalent cation transporter; Region: MgtE; pfam01769 707235000990 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 707235000991 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 707235000992 active site 707235000993 intersubunit interface [polypeptide binding]; other site 707235000994 zinc binding site [ion binding]; other site 707235000995 Na+ binding site [ion binding]; other site 707235000996 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 707235000997 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 707235000998 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 707235000999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 707235001000 AAA domain; Region: AAA_33; pfam13671 707235001001 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 707235001002 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 707235001003 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 707235001004 putative hydrophobic ligand binding site [chemical binding]; other site 707235001005 MoxR-like ATPases [General function prediction only]; Region: COG0714 707235001006 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 707235001007 Ligand binding site; other site 707235001008 metal-binding site 707235001009 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 707235001010 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 707235001011 XdhC Rossmann domain; Region: XdhC_C; pfam13478 707235001012 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 707235001013 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 707235001014 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 707235001015 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 707235001016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235001017 catalytic loop [active] 707235001018 iron binding site [ion binding]; other site 707235001019 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 707235001020 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 707235001021 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 707235001022 Uncharacterized conserved protein [Function unknown]; Region: COG3360 707235001023 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 707235001024 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 707235001025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235001026 active site 707235001027 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 707235001028 Clp amino terminal domain; Region: Clp_N; pfam02861 707235001029 Clp amino terminal domain; Region: Clp_N; pfam02861 707235001030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235001031 Walker A motif; other site 707235001032 ATP binding site [chemical binding]; other site 707235001033 Walker B motif; other site 707235001034 arginine finger; other site 707235001035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235001036 Walker A motif; other site 707235001037 ATP binding site [chemical binding]; other site 707235001038 Walker B motif; other site 707235001039 arginine finger; other site 707235001040 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 707235001041 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 707235001042 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 707235001043 heme-binding site [chemical binding]; other site 707235001044 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 707235001045 FAD binding pocket [chemical binding]; other site 707235001046 FAD binding motif [chemical binding]; other site 707235001047 phosphate binding motif [ion binding]; other site 707235001048 beta-alpha-beta structure motif; other site 707235001049 NAD binding pocket [chemical binding]; other site 707235001050 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235001051 cyclase homology domain; Region: CHD; cd07302 707235001052 nucleotidyl binding site; other site 707235001053 metal binding site [ion binding]; metal-binding site 707235001054 dimer interface [polypeptide binding]; other site 707235001055 Predicted ATPase [General function prediction only]; Region: COG3903 707235001056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 707235001057 Walker A motif; other site 707235001058 ATP binding site [chemical binding]; other site 707235001059 Walker B motif; other site 707235001060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235001061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235001062 DNA binding residues [nucleotide binding] 707235001063 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235001064 PPE family; Region: PPE; pfam00823 707235001065 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 707235001066 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 707235001067 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235001068 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 707235001069 active site residue [active] 707235001070 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 707235001071 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 707235001072 homodimer interface [polypeptide binding]; other site 707235001073 substrate-cofactor binding pocket; other site 707235001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235001075 catalytic residue [active] 707235001076 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 707235001077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235001078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235001079 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235001080 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235001081 active site 707235001082 PLD-like domain; Region: PLDc_2; pfam13091 707235001083 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235001084 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235001085 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 707235001086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235001087 FAD binding site [chemical binding]; other site 707235001088 substrate binding pocket [chemical binding]; other site 707235001089 catalytic base [active] 707235001090 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 707235001091 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235001092 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 707235001093 acyl-CoA synthetase; Validated; Region: PRK05850 707235001094 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235001095 acyl-activating enzyme (AAE) consensus motif; other site 707235001096 active site 707235001097 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 707235001098 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235001099 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 707235001100 active site 707235001101 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235001102 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235001103 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235001104 Thioesterase; Region: PKS_TE; smart00824 707235001105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 707235001106 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 707235001107 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 707235001108 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235001109 phosphate acetyltransferase; Reviewed; Region: PRK05632 707235001110 DRTGG domain; Region: DRTGG; pfam07085 707235001111 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 707235001112 propionate/acetate kinase; Provisional; Region: PRK12379 707235001113 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 707235001114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235001115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235001116 active site 707235001117 ATP binding site [chemical binding]; other site 707235001118 substrate binding site [chemical binding]; other site 707235001119 activation loop (A-loop); other site 707235001120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 707235001121 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 707235001122 substrate binding pocket [chemical binding]; other site 707235001123 membrane-bound complex binding site; other site 707235001124 hinge residues; other site 707235001125 NUDIX domain; Region: NUDIX; pfam00293 707235001126 nudix motif; other site 707235001127 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 707235001128 thiamine phosphate binding site [chemical binding]; other site 707235001129 active site 707235001130 pyrophosphate binding site [ion binding]; other site 707235001131 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 707235001132 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 707235001133 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 707235001134 thiS-thiF/thiG interaction site; other site 707235001135 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 707235001136 ThiS interaction site; other site 707235001137 putative active site [active] 707235001138 tetramer interface [polypeptide binding]; other site 707235001139 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 707235001140 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 707235001141 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 707235001142 PA/protease or protease-like domain interface [polypeptide binding]; other site 707235001143 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 707235001144 active site 707235001145 metal binding site [ion binding]; metal-binding site 707235001146 Predicted metalloprotease [General function prediction only]; Region: COG2321 707235001147 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 707235001148 Zn binding site [ion binding]; other site 707235001149 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 707235001150 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 707235001151 dimer interface [polypeptide binding]; other site 707235001152 substrate binding site [chemical binding]; other site 707235001153 ATP binding site [chemical binding]; other site 707235001154 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 707235001155 ThiC-associated domain; Region: ThiC-associated; pfam13667 707235001156 ThiC family; Region: ThiC; pfam01964 707235001157 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235001158 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 707235001159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235001160 motif II; other site 707235001161 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 707235001162 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 707235001163 putative catalytic site [active] 707235001164 putative phosphate binding site [ion binding]; other site 707235001165 active site 707235001166 metal binding site A [ion binding]; metal-binding site 707235001167 DNA binding site [nucleotide binding] 707235001168 putative AP binding site [nucleotide binding]; other site 707235001169 putative metal binding site B [ion binding]; other site 707235001170 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 707235001171 active site 707235001172 catalytic residues [active] 707235001173 metal binding site [ion binding]; metal-binding site 707235001174 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 707235001175 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 707235001176 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 707235001177 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 707235001178 E-class dimer interface [polypeptide binding]; other site 707235001179 P-class dimer interface [polypeptide binding]; other site 707235001180 active site 707235001181 Cu2+ binding site [ion binding]; other site 707235001182 Zn2+ binding site [ion binding]; other site 707235001183 carboxylate-amine ligase; Provisional; Region: PRK13517 707235001184 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 707235001185 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 707235001186 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 707235001187 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 707235001188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235001189 Walker A motif; other site 707235001190 ATP binding site [chemical binding]; other site 707235001191 Walker B motif; other site 707235001192 arginine finger; other site 707235001193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235001194 Walker A motif; other site 707235001195 ATP binding site [chemical binding]; other site 707235001196 Walker B motif; other site 707235001197 arginine finger; other site 707235001198 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 707235001199 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 707235001200 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 707235001201 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 707235001202 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 707235001203 dimer interface [polypeptide binding]; other site 707235001204 putative functional site; other site 707235001205 putative MPT binding site; other site 707235001206 short chain dehydrogenase; Provisional; Region: PRK06197 707235001207 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 707235001208 putative NAD(P) binding site [chemical binding]; other site 707235001209 active site 707235001210 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 707235001211 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 707235001212 ring oligomerisation interface [polypeptide binding]; other site 707235001213 ATP/Mg binding site [chemical binding]; other site 707235001214 stacking interactions; other site 707235001215 hinge regions; other site 707235001216 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235001217 PPE family; Region: PPE; pfam00823 707235001218 Protein of unknown function (DUF664); Region: DUF664; pfam04978 707235001219 DinB superfamily; Region: DinB_2; pfam12867 707235001220 putative anti-sigmaE protein; Provisional; Region: PRK13920 707235001221 Anti-sigma-K factor rskA; Region: RskA; pfam10099 707235001222 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 707235001223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235001224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235001225 DNA binding residues [nucleotide binding] 707235001226 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 707235001227 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001229 S-adenosylmethionine binding site [chemical binding]; other site 707235001230 Uncharacterized conserved protein [Function unknown]; Region: COG3496 707235001231 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 707235001232 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 707235001233 dimer interface [polypeptide binding]; other site 707235001234 Transport protein; Region: actII; TIGR00833 707235001235 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 707235001236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235001237 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235001238 PPE family; Region: PPE; pfam00823 707235001239 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235001240 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 707235001241 enoyl-CoA hydratase; Provisional; Region: PRK12478 707235001242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235001243 substrate binding site [chemical binding]; other site 707235001244 oxyanion hole (OAH) forming residues; other site 707235001245 trimer interface [polypeptide binding]; other site 707235001246 PemK-like protein; Region: PemK; pfam02452 707235001247 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 707235001248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235001249 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 707235001250 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 707235001251 NAD(P) binding site [chemical binding]; other site 707235001252 catalytic residues [active] 707235001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 707235001254 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 707235001255 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 707235001256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235001257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707235001258 Uncharacterized conserved protein [Function unknown]; Region: COG2128 707235001259 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 707235001260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235001261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235001262 non-specific DNA binding site [nucleotide binding]; other site 707235001263 salt bridge; other site 707235001264 sequence-specific DNA binding site [nucleotide binding]; other site 707235001265 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 707235001266 Domain of unknown function (DUF955); Region: DUF955; pfam06114 707235001267 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 707235001268 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 707235001269 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 707235001270 active site 707235001271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 707235001272 active site 2 [active] 707235001273 isocitrate lyase; Provisional; Region: PRK15063 707235001274 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 707235001275 oligomerization interface [polypeptide binding]; other site 707235001276 active site 707235001277 metal binding site [ion binding]; metal-binding site 707235001278 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 707235001279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 707235001280 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 707235001281 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001283 S-adenosylmethionine binding site [chemical binding]; other site 707235001284 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001287 S-adenosylmethionine binding site [chemical binding]; other site 707235001288 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 707235001289 UbiA prenyltransferase family; Region: UbiA; pfam01040 707235001290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235001292 Predicted membrane protein [Function unknown]; Region: COG2733 707235001293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235001294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235001295 non-specific DNA binding site [nucleotide binding]; other site 707235001296 salt bridge; other site 707235001297 sequence-specific DNA binding site [nucleotide binding]; other site 707235001298 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 707235001299 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 707235001300 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 707235001301 intersubunit interface [polypeptide binding]; other site 707235001302 active site 707235001303 catalytic residue [active] 707235001304 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 707235001305 Predicted amidohydrolase [General function prediction only]; Region: COG0388 707235001306 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 707235001307 putative active site [active] 707235001308 catalytic triad [active] 707235001309 putative dimer interface [polypeptide binding]; other site 707235001310 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 707235001311 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 707235001312 FAD binding domain; Region: FAD_binding_4; pfam01565 707235001313 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 707235001314 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 707235001315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 707235001316 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 707235001317 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 707235001318 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 707235001319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235001320 NAD(P) binding site [chemical binding]; other site 707235001321 active site 707235001322 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 707235001323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235001324 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 707235001325 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 707235001326 putative ADP-binding pocket [chemical binding]; other site 707235001327 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 707235001328 L-lysine exporter; Region: 2a75; TIGR00948 707235001329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235001330 catalytic core [active] 707235001331 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 707235001332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235001333 dimer interface [polypeptide binding]; other site 707235001334 phosphorylation site [posttranslational modification] 707235001335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235001336 ATP binding site [chemical binding]; other site 707235001337 Mg2+ binding site [ion binding]; other site 707235001338 G-X-G motif; other site 707235001339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235001340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235001341 active site 707235001342 phosphorylation site [posttranslational modification] 707235001343 intermolecular recognition site; other site 707235001344 dimerization interface [polypeptide binding]; other site 707235001345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235001346 DNA binding site [nucleotide binding] 707235001347 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 707235001348 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 707235001349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 707235001350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235001351 DNA-binding site [nucleotide binding]; DNA binding site 707235001352 FCD domain; Region: FCD; pfam07729 707235001353 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 707235001354 exopolyphosphatase; Region: exo_poly_only; TIGR03706 707235001355 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 707235001356 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 707235001357 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 707235001358 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 707235001359 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 707235001360 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 707235001361 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 707235001362 DNA binding domain, excisionase family; Region: excise; TIGR01764 707235001363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235001364 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 707235001365 putative NAD(P) binding site [chemical binding]; other site 707235001366 active site 707235001367 putative substrate binding site [chemical binding]; other site 707235001368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235001369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 707235001370 putative acyl-acceptor binding pocket; other site 707235001371 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001374 S-adenosylmethionine binding site [chemical binding]; other site 707235001375 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 707235001376 active site 707235001377 catalytic site [active] 707235001378 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 707235001379 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 707235001380 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 707235001381 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235001382 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 707235001383 glutamyl-tRNA reductase; Region: hemA; TIGR01035 707235001384 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 707235001385 tRNA; other site 707235001386 putative tRNA binding site [nucleotide binding]; other site 707235001387 putative NADP binding site [chemical binding]; other site 707235001388 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 707235001389 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 707235001390 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 707235001391 domain interfaces; other site 707235001392 active site 707235001393 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 707235001394 active site 707235001395 homodimer interface [polypeptide binding]; other site 707235001396 SAM binding site [chemical binding]; other site 707235001397 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 707235001398 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 707235001399 active site 707235001400 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 707235001401 dimer interface [polypeptide binding]; other site 707235001402 active site 707235001403 Schiff base residues; other site 707235001404 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235001405 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235001406 active site 707235001407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235001408 anti sigma factor interaction site; other site 707235001409 regulatory phosphorylation site [posttranslational modification]; other site 707235001410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 707235001411 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 707235001412 active site 707235001413 catalytic triad [active] 707235001414 oxyanion hole [active] 707235001415 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 707235001416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235001418 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 707235001419 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235001420 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 707235001421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235001422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235001423 catalytic residue [active] 707235001424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235001425 catalytic core [active] 707235001426 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 707235001427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235001428 catalytic residues [active] 707235001429 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 707235001430 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 707235001431 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 707235001432 ResB-like family; Region: ResB; pfam05140 707235001433 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 707235001434 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235001435 AAA domain; Region: AAA_31; pfam13614 707235001436 P-loop; other site 707235001437 Magnesium ion binding site [ion binding]; other site 707235001438 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 707235001439 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 707235001440 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 707235001441 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 707235001442 dimer interface [polypeptide binding]; other site 707235001443 active site 707235001444 CoA binding pocket [chemical binding]; other site 707235001445 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 707235001446 UbiA prenyltransferase family; Region: UbiA; pfam01040 707235001447 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 707235001448 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235001449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235001450 NAD(P) binding site [chemical binding]; other site 707235001451 active site 707235001452 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 707235001453 Ligand binding site; other site 707235001454 Putative Catalytic site; other site 707235001455 DXD motif; other site 707235001456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 707235001457 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 707235001458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235001459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235001460 acyl-activating enzyme (AAE) consensus motif; other site 707235001461 acyl-activating enzyme (AAE) consensus motif; other site 707235001462 AMP binding site [chemical binding]; other site 707235001463 active site 707235001464 CoA binding site [chemical binding]; other site 707235001465 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 707235001466 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 707235001467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235001468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 707235001469 active site 707235001470 short chain dehydrogenase; Provisional; Region: PRK05866 707235001471 classical (c) SDRs; Region: SDR_c; cd05233 707235001472 NAD(P) binding site [chemical binding]; other site 707235001473 active site 707235001474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235001475 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 707235001476 substrate binding site [chemical binding]; other site 707235001477 oxyanion hole (OAH) forming residues; other site 707235001478 trimer interface [polypeptide binding]; other site 707235001479 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 707235001480 putative active site [active] 707235001481 homotetrameric interface [polypeptide binding]; other site 707235001482 metal binding site [ion binding]; metal-binding site 707235001483 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 707235001484 acyl-CoA synthetase; Validated; Region: PRK06188 707235001485 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 707235001486 putative active site [active] 707235001487 putative CoA binding site [chemical binding]; other site 707235001488 putative AMP binding site [chemical binding]; other site 707235001489 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 707235001490 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 707235001491 active site 707235001492 O-succinylbenzoate synthase; Provisional; Region: PRK02901 707235001493 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 707235001494 active site 707235001495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235001496 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 707235001497 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235001498 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 707235001499 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 707235001500 dimer interface [polypeptide binding]; other site 707235001501 tetramer interface [polypeptide binding]; other site 707235001502 PYR/PP interface [polypeptide binding]; other site 707235001503 TPP binding site [chemical binding]; other site 707235001504 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 707235001505 TPP-binding site; other site 707235001506 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 707235001507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 707235001508 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 707235001509 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 707235001510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001511 S-adenosylmethionine binding site [chemical binding]; other site 707235001512 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235001513 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235001514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001515 S-adenosylmethionine binding site [chemical binding]; other site 707235001516 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 707235001517 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 707235001518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707235001519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707235001520 substrate binding pocket [chemical binding]; other site 707235001521 chain length determination region; other site 707235001522 substrate-Mg2+ binding site; other site 707235001523 catalytic residues [active] 707235001524 aspartate-rich region 1; other site 707235001525 active site lid residues [active] 707235001526 aspartate-rich region 2; other site 707235001527 heat shock protein HtpX; Provisional; Region: PRK03072 707235001528 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 707235001529 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 707235001530 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 707235001531 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235001532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235001533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 707235001534 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 707235001535 O-methyltransferase; Region: Methyltransf_2; pfam00891 707235001536 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235001537 Cytochrome P450; Region: p450; cl12078 707235001538 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 707235001539 ATP cone domain; Region: ATP-cone; pfam03477 707235001540 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 707235001541 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 707235001542 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 707235001543 active site 707235001544 dimer interface [polypeptide binding]; other site 707235001545 effector binding site; other site 707235001546 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 707235001547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235001548 active site 707235001549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235001550 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 707235001551 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 707235001552 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 707235001553 active site 707235001554 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 707235001555 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 707235001556 putative active site [active] 707235001557 putative metal binding site [ion binding]; other site 707235001558 hypothetical protein; Provisional; Region: PRK07588 707235001559 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 707235001560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235001561 dimerization interface [polypeptide binding]; other site 707235001562 putative DNA binding site [nucleotide binding]; other site 707235001563 putative Zn2+ binding site [ion binding]; other site 707235001564 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 707235001565 putative hydrophobic ligand binding site [chemical binding]; other site 707235001566 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235001567 TIGR03086 family protein; Region: TIGR03086 707235001568 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 707235001569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235001570 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 707235001571 PE family; Region: PE; pfam00934 707235001572 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 707235001573 Uncharacterized conserved protein [Function unknown]; Region: COG1656 707235001574 Protein of unknown function DUF82; Region: DUF82; pfam01927 707235001575 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235001576 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235001577 putative active site [active] 707235001578 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 707235001579 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 707235001580 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 707235001581 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 707235001582 Transcriptional regulators [Transcription]; Region: FadR; COG2186 707235001583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235001584 DNA-binding site [nucleotide binding]; DNA binding site 707235001585 FCD domain; Region: FCD; pfam07729 707235001586 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235001587 Permease; Region: Permease; pfam02405 707235001588 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235001589 Permease; Region: Permease; pfam02405 707235001590 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235001591 mce related protein; Region: MCE; pfam02470 707235001592 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235001593 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 707235001594 mce related protein; Region: MCE; pfam02470 707235001595 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235001596 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235001597 mce related protein; Region: MCE; pfam02470 707235001598 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235001599 mce related protein; Region: MCE; pfam02470 707235001600 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235001601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235001602 mce related protein; Region: MCE; pfam02470 707235001603 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235001604 mce related protein; Region: MCE; pfam02470 707235001605 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 707235001606 oligomeric interface; other site 707235001607 putative active site [active] 707235001608 homodimer interface [polypeptide binding]; other site 707235001609 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235001610 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 707235001611 AAA domain; Region: AAA_14; pfam13173 707235001612 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 707235001613 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 707235001614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235001615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235001616 ATP binding site [chemical binding]; other site 707235001617 Mg2+ binding site [ion binding]; other site 707235001618 G-X-G motif; other site 707235001619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235001620 dimerization interface [polypeptide binding]; other site 707235001621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235001622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235001623 active site 707235001624 phosphorylation site [posttranslational modification] 707235001625 intermolecular recognition site; other site 707235001626 dimerization interface [polypeptide binding]; other site 707235001627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235001628 DNA binding site [nucleotide binding] 707235001629 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 707235001630 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 707235001631 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235001632 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 707235001633 catalytic residues [active] 707235001634 catalytic nucleophile [active] 707235001635 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 707235001636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235001637 Probable transposase; Region: OrfB_IS605; pfam01385 707235001638 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 707235001639 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 707235001640 putative active site [active] 707235001641 SEC-C motif; Region: SEC-C; pfam02810 707235001642 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 707235001643 putative active site [active] 707235001644 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 707235001645 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 707235001646 nucleotide binding site/active site [active] 707235001647 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 707235001648 galactokinase; Provisional; Region: PRK00555 707235001649 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 707235001650 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235001651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 707235001652 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 707235001653 putative active site [active] 707235001654 Uncharacterized conserved protein [Function unknown]; Region: COG0398 707235001655 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 707235001656 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235001657 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 707235001658 oligomeric interface; other site 707235001659 putative active site [active] 707235001660 homodimer interface [polypeptide binding]; other site 707235001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 707235001662 FIST N domain; Region: FIST; pfam08495 707235001663 FIST C domain; Region: FIST_C; pfam10442 707235001664 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 707235001665 AAA domain; Region: AAA_30; pfam13604 707235001666 Family description; Region: UvrD_C_2; pfam13538 707235001667 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 707235001668 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 707235001669 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 707235001670 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 707235001671 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235001672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235001673 substrate binding site [chemical binding]; other site 707235001674 oxyanion hole (OAH) forming residues; other site 707235001675 trimer interface [polypeptide binding]; other site 707235001676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 707235001677 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235001678 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 707235001679 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 707235001680 active site 707235001681 catalytic site [active] 707235001682 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 707235001683 active site 707235001684 catalytic site [active] 707235001685 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 707235001686 active site 707235001687 catalytic site [active] 707235001688 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 707235001689 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 707235001690 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 707235001691 putative homodimer interface [polypeptide binding]; other site 707235001692 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 707235001693 heterodimer interface [polypeptide binding]; other site 707235001694 homodimer interface [polypeptide binding]; other site 707235001695 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 707235001696 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 707235001697 23S rRNA interface [nucleotide binding]; other site 707235001698 L7/L12 interface [polypeptide binding]; other site 707235001699 putative thiostrepton binding site; other site 707235001700 L25 interface [polypeptide binding]; other site 707235001701 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 707235001702 mRNA/rRNA interface [nucleotide binding]; other site 707235001703 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001705 S-adenosylmethionine binding site [chemical binding]; other site 707235001706 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001709 S-adenosylmethionine binding site [chemical binding]; other site 707235001710 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001713 S-adenosylmethionine binding site [chemical binding]; other site 707235001714 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235001717 S-adenosylmethionine binding site [chemical binding]; other site 707235001718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235001719 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235001720 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 707235001721 ABC1 family; Region: ABC1; cl17513 707235001722 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 707235001723 active site 707235001724 catalytic site [active] 707235001725 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 707235001726 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 707235001727 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 707235001728 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 707235001729 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235001730 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 707235001731 23S rRNA interface [nucleotide binding]; other site 707235001732 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 707235001733 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 707235001734 core dimer interface [polypeptide binding]; other site 707235001735 peripheral dimer interface [polypeptide binding]; other site 707235001736 L10 interface [polypeptide binding]; other site 707235001737 L11 interface [polypeptide binding]; other site 707235001738 putative EF-Tu interaction site [polypeptide binding]; other site 707235001739 putative EF-G interaction site [polypeptide binding]; other site 707235001740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235001741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235001742 WHG domain; Region: WHG; pfam13305 707235001743 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 707235001744 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 707235001745 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 707235001746 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 707235001747 Walker A/P-loop; other site 707235001748 ATP binding site [chemical binding]; other site 707235001749 Q-loop/lid; other site 707235001750 ABC transporter signature motif; other site 707235001751 Walker B; other site 707235001752 D-loop; other site 707235001753 H-loop/switch region; other site 707235001754 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 707235001755 putative active site [active] 707235001756 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235001757 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 707235001758 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235001759 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 707235001760 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 707235001761 Sulfatase; Region: Sulfatase; pfam00884 707235001762 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 707235001763 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 707235001764 putative active site [active] 707235001765 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 707235001766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 707235001767 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 707235001768 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 707235001769 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 707235001770 RPB10 interaction site [polypeptide binding]; other site 707235001771 RPB1 interaction site [polypeptide binding]; other site 707235001772 RPB11 interaction site [polypeptide binding]; other site 707235001773 RPB3 interaction site [polypeptide binding]; other site 707235001774 RPB12 interaction site [polypeptide binding]; other site 707235001775 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 707235001776 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 707235001777 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 707235001778 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 707235001779 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 707235001780 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 707235001781 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 707235001782 G-loop; other site 707235001783 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 707235001784 DNA binding site [nucleotide binding] 707235001785 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 707235001786 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 707235001787 endonuclease IV; Provisional; Region: PRK01060 707235001788 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 707235001789 AP (apurinic/apyrimidinic) site pocket; other site 707235001790 Metal-binding active site; metal-binding site 707235001791 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 707235001792 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 707235001793 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 707235001794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235001795 active site 707235001796 enoyl-CoA hydratase; Provisional; Region: PRK12478 707235001797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235001798 substrate binding site [chemical binding]; other site 707235001799 oxyanion hole (OAH) forming residues; other site 707235001800 trimer interface [polypeptide binding]; other site 707235001801 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 707235001802 PaaX-like protein; Region: PaaX; pfam07848 707235001803 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 707235001804 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235001805 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235001806 substrate binding site [chemical binding]; other site 707235001807 oxyanion hole (OAH) forming residues; other site 707235001808 trimer interface [polypeptide binding]; other site 707235001809 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235001810 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 707235001811 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 707235001812 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 707235001813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235001814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235001815 WHG domain; Region: WHG; pfam13305 707235001816 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 707235001817 S17 interaction site [polypeptide binding]; other site 707235001818 S8 interaction site; other site 707235001819 16S rRNA interaction site [nucleotide binding]; other site 707235001820 streptomycin interaction site [chemical binding]; other site 707235001821 23S rRNA interaction site [nucleotide binding]; other site 707235001822 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 707235001823 30S ribosomal protein S7; Validated; Region: PRK05302 707235001824 elongation factor G; Reviewed; Region: PRK00007 707235001825 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 707235001826 G1 box; other site 707235001827 putative GEF interaction site [polypeptide binding]; other site 707235001828 GTP/Mg2+ binding site [chemical binding]; other site 707235001829 Switch I region; other site 707235001830 G2 box; other site 707235001831 G3 box; other site 707235001832 Switch II region; other site 707235001833 G4 box; other site 707235001834 G5 box; other site 707235001835 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 707235001836 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 707235001837 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 707235001838 elongation factor Tu; Reviewed; Region: PRK00049 707235001839 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 707235001840 G1 box; other site 707235001841 GEF interaction site [polypeptide binding]; other site 707235001842 GTP/Mg2+ binding site [chemical binding]; other site 707235001843 Switch I region; other site 707235001844 G2 box; other site 707235001845 G3 box; other site 707235001846 Switch II region; other site 707235001847 G4 box; other site 707235001848 G5 box; other site 707235001849 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 707235001850 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 707235001851 Antibiotic Binding Site [chemical binding]; other site 707235001852 Short C-terminal domain; Region: SHOCT; pfam09851 707235001853 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 707235001854 classical (c) SDRs; Region: SDR_c; cd05233 707235001855 NAD(P) binding site [chemical binding]; other site 707235001856 active site 707235001857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 707235001858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235001859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 707235001860 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 707235001861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235001862 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 707235001863 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 707235001864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235001865 FeS/SAM binding site; other site 707235001866 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 707235001867 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 707235001868 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235001869 phosphate binding site [ion binding]; other site 707235001870 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 707235001871 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 707235001872 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 707235001873 Probable Catalytic site; other site 707235001874 metal-binding site 707235001875 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 707235001876 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 707235001877 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 707235001878 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 707235001879 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 707235001880 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 707235001881 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 707235001882 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 707235001883 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 707235001884 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 707235001885 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 707235001886 putative translocon binding site; other site 707235001887 protein-rRNA interface [nucleotide binding]; other site 707235001888 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 707235001889 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 707235001890 G-X-X-G motif; other site 707235001891 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 707235001892 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 707235001893 23S rRNA interface [nucleotide binding]; other site 707235001894 5S rRNA interface [nucleotide binding]; other site 707235001895 putative antibiotic binding site [chemical binding]; other site 707235001896 L25 interface [polypeptide binding]; other site 707235001897 L27 interface [polypeptide binding]; other site 707235001898 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 707235001899 putative translocon interaction site; other site 707235001900 23S rRNA interface [nucleotide binding]; other site 707235001901 signal recognition particle (SRP54) interaction site; other site 707235001902 L23 interface [polypeptide binding]; other site 707235001903 trigger factor interaction site; other site 707235001904 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 707235001905 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 707235001906 Sulfatase; Region: Sulfatase; pfam00884 707235001907 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 707235001908 Uncharacterized conserved protein [Function unknown]; Region: COG1262 707235001909 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 707235001910 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 707235001911 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 707235001912 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 707235001913 RNA binding site [nucleotide binding]; other site 707235001914 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 707235001915 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 707235001916 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 707235001917 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 707235001918 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 707235001919 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 707235001920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 707235001921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 707235001922 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 707235001923 5S rRNA interface [nucleotide binding]; other site 707235001924 23S rRNA interface [nucleotide binding]; other site 707235001925 L5 interface [polypeptide binding]; other site 707235001926 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 707235001927 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 707235001928 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 707235001929 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 707235001930 23S rRNA binding site [nucleotide binding]; other site 707235001931 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 707235001932 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 707235001933 tandem repeat interface [polypeptide binding]; other site 707235001934 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 707235001935 oligomer interface [polypeptide binding]; other site 707235001936 active site residues [active] 707235001937 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 707235001938 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 707235001939 tandem repeat interface [polypeptide binding]; other site 707235001940 oligomer interface [polypeptide binding]; other site 707235001941 active site residues [active] 707235001942 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235001943 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235001944 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235001945 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235001946 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 707235001947 intersubunit interface [polypeptide binding]; other site 707235001948 active site 707235001949 Zn2+ binding site [ion binding]; other site 707235001950 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 707235001951 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 707235001952 NAD binding site [chemical binding]; other site 707235001953 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 707235001954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235001955 nucleotide binding site [chemical binding]; other site 707235001956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 707235001957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235001958 Coenzyme A binding pocket [chemical binding]; other site 707235001959 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235001960 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235001961 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 707235001962 SecY translocase; Region: SecY; pfam00344 707235001963 adenylate kinase; Reviewed; Region: adk; PRK00279 707235001964 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 707235001965 AMP-binding site [chemical binding]; other site 707235001966 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 707235001967 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 707235001968 active site 707235001969 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 707235001970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235001971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235001972 DNA binding residues [nucleotide binding] 707235001973 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 707235001974 Putative zinc-finger; Region: zf-HC2; pfam13490 707235001975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235001976 MarR family; Region: MarR; pfam01047 707235001977 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235001978 TIGR03086 family protein; Region: TIGR03086 707235001979 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 707235001980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 707235001981 Transposase; Region: DDE_Tnp_ISL3; pfam01610 707235001982 Helix-turn-helix domain; Region: HTH_17; pfam12728 707235001983 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 707235001984 PE family; Region: PE; pfam00934 707235001985 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235001986 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235001987 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 707235001988 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 707235001989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235001990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235001991 active site 707235001992 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 707235001993 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 707235001994 tetrameric interface [polypeptide binding]; other site 707235001995 NAD binding site [chemical binding]; other site 707235001996 catalytic residues [active] 707235001997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235001998 catalytic core [active] 707235001999 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235002000 PPE family; Region: PPE; pfam00823 707235002001 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235002002 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235002003 Helix-turn-helix domain; Region: HTH_28; pfam13518 707235002004 Winged helix-turn helix; Region: HTH_29; pfam13551 707235002005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235002006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002007 active site 707235002008 phosphorylation site [posttranslational modification] 707235002009 intermolecular recognition site; other site 707235002010 dimerization interface [polypeptide binding]; other site 707235002011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002012 DNA binding site [nucleotide binding] 707235002013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235002014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235002015 dimerization interface [polypeptide binding]; other site 707235002016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235002017 dimer interface [polypeptide binding]; other site 707235002018 phosphorylation site [posttranslational modification] 707235002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235002020 ATP binding site [chemical binding]; other site 707235002021 Mg2+ binding site [ion binding]; other site 707235002022 G-X-G motif; other site 707235002023 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 707235002024 nucleotide binding site/active site [active] 707235002025 HIT family signature motif; other site 707235002026 catalytic residue [active] 707235002027 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 707235002028 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 707235002029 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 707235002030 NAD binding site [chemical binding]; other site 707235002031 catalytic Zn binding site [ion binding]; other site 707235002032 substrate binding site [chemical binding]; other site 707235002033 structural Zn binding site [ion binding]; other site 707235002034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 707235002035 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 707235002036 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 707235002037 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235002038 Cytochrome P450; Region: p450; cl12078 707235002039 short chain dehydrogenase; Provisional; Region: PRK07775 707235002040 classical (c) SDRs; Region: SDR_c; cd05233 707235002041 NAD(P) binding site [chemical binding]; other site 707235002042 active site 707235002043 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235002044 Cytochrome P450; Region: p450; cl12078 707235002045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235002046 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 707235002047 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 707235002048 NAD binding site [chemical binding]; other site 707235002049 catalytic residues [active] 707235002050 short chain dehydrogenase; Provisional; Region: PRK07774 707235002051 classical (c) SDRs; Region: SDR_c; cd05233 707235002052 NAD(P) binding site [chemical binding]; other site 707235002053 active site 707235002054 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 707235002055 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 707235002056 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 707235002057 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 707235002058 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 707235002059 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 707235002060 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 707235002061 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 707235002062 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 707235002063 Predicted esterase [General function prediction only]; Region: COG0627 707235002064 S-formylglutathione hydrolase; Region: PLN02442 707235002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 707235002066 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 707235002067 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 707235002068 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 707235002069 tetramer interface [polypeptide binding]; other site 707235002070 active site 707235002071 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235002072 Cytochrome P450; Region: p450; cl12078 707235002073 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 707235002074 ATP binding site [chemical binding]; other site 707235002075 active site 707235002076 substrate binding site [chemical binding]; other site 707235002077 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 707235002078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235002079 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235002081 putative substrate translocation pore; other site 707235002082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235002083 Predicted deacetylase [General function prediction only]; Region: COG3233 707235002084 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 707235002085 putative active site [active] 707235002086 putative Zn binding site [ion binding]; other site 707235002087 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 707235002088 FAD binding domain; Region: FAD_binding_2; pfam00890 707235002089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 707235002090 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 707235002091 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 707235002092 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 707235002093 putative active site [active] 707235002094 catalytic triad [active] 707235002095 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 707235002096 Transglutaminase/protease-like homologues; Region: TGc; smart00460 707235002097 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235002098 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 707235002099 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 707235002100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235002101 DNA-binding site [nucleotide binding]; DNA binding site 707235002102 UTRA domain; Region: UTRA; pfam07702 707235002103 Uncharacterized conserved protein [Function unknown]; Region: COG1359 707235002104 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 707235002105 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 707235002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235002107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707235002108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 707235002109 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235002110 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 707235002111 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 707235002112 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 707235002113 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 707235002114 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 707235002115 active site 707235002116 metal binding site [ion binding]; metal-binding site 707235002117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 707235002118 active site 707235002119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235002120 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 707235002121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 707235002122 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 707235002123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 707235002124 dimerization interface [polypeptide binding]; other site 707235002125 ATP binding site [chemical binding]; other site 707235002126 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 707235002127 dimerization interface [polypeptide binding]; other site 707235002128 ATP binding site [chemical binding]; other site 707235002129 CAAX protease self-immunity; Region: Abi; pfam02517 707235002130 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 707235002131 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 707235002132 active site 707235002133 metal binding site [ion binding]; metal-binding site 707235002134 hexamer interface [polypeptide binding]; other site 707235002135 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 707235002136 amidophosphoribosyltransferase; Provisional; Region: PRK07847 707235002137 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 707235002138 active site 707235002139 tetramer interface [polypeptide binding]; other site 707235002140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235002141 active site 707235002142 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 707235002143 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 707235002144 dimerization interface [polypeptide binding]; other site 707235002145 putative ATP binding site [chemical binding]; other site 707235002146 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 707235002147 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 707235002148 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 707235002149 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 707235002150 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 707235002151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235002152 catalytic residue [active] 707235002153 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 707235002154 heme-binding site [chemical binding]; other site 707235002155 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 707235002156 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 707235002157 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 707235002158 active site residue [active] 707235002159 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 707235002160 active site residue [active] 707235002161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 707235002162 catalytic residues [active] 707235002163 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 707235002164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235002165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002166 DNA binding site [nucleotide binding] 707235002167 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 707235002168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235002169 Coenzyme A binding pocket [chemical binding]; other site 707235002170 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 707235002171 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 707235002172 Walker A/P-loop; other site 707235002173 ATP binding site [chemical binding]; other site 707235002174 Q-loop/lid; other site 707235002175 ABC transporter signature motif; other site 707235002176 Walker B; other site 707235002177 D-loop; other site 707235002178 H-loop/switch region; other site 707235002179 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 707235002180 PhoU domain; Region: PhoU; pfam01895 707235002181 PhoU domain; Region: PhoU; pfam01895 707235002182 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 707235002183 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 707235002184 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 707235002185 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 707235002186 FMN binding site [chemical binding]; other site 707235002187 active site 707235002188 catalytic residues [active] 707235002189 substrate binding site [chemical binding]; other site 707235002190 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 707235002191 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 707235002192 homodimer interface [polypeptide binding]; other site 707235002193 putative substrate binding pocket [chemical binding]; other site 707235002194 diiron center [ion binding]; other site 707235002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 707235002196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235002197 dimerization interface [polypeptide binding]; other site 707235002198 putative DNA binding site [nucleotide binding]; other site 707235002199 putative Zn2+ binding site [ion binding]; other site 707235002200 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 707235002201 dimer interface [polypeptide binding]; other site 707235002202 catalytic motif [active] 707235002203 nucleoside/Zn binding site; other site 707235002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235002205 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235002206 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235002207 TIGR04255 family protein; Region: sporadTIGR04255 707235002208 PE family; Region: PE; pfam00934 707235002209 PE family; Region: PE; pfam00934 707235002210 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235002211 putative transposase OrfB; Reviewed; Region: PHA02517 707235002212 HTH-like domain; Region: HTH_21; pfam13276 707235002213 Integrase core domain; Region: rve; pfam00665 707235002214 Integrase core domain; Region: rve_3; pfam13683 707235002215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235002216 Transposase; Region: HTH_Tnp_1; cl17663 707235002217 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 707235002218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 707235002219 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 707235002220 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 707235002221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235002222 S-adenosylmethionine binding site [chemical binding]; other site 707235002223 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 707235002224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235002225 putative substrate translocation pore; other site 707235002226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235002227 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 707235002228 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 707235002229 tetramer interface [polypeptide binding]; other site 707235002230 TPP-binding site [chemical binding]; other site 707235002231 heterodimer interface [polypeptide binding]; other site 707235002232 phosphorylation loop region [posttranslational modification] 707235002233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235002234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002235 active site 707235002236 phosphorylation site [posttranslational modification] 707235002237 intermolecular recognition site; other site 707235002238 dimerization interface [polypeptide binding]; other site 707235002239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235002240 DNA binding residues [nucleotide binding] 707235002241 dimerization interface [polypeptide binding]; other site 707235002242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 707235002243 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 707235002244 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 707235002245 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 707235002246 Multicopper oxidase; Region: Cu-oxidase; pfam00394 707235002247 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 707235002248 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 707235002249 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 707235002250 dimer interface [polypeptide binding]; other site 707235002251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235002252 catalytic residue [active] 707235002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235002254 multidrug resistance protein MdtH; Provisional; Region: PRK11646 707235002255 putative substrate translocation pore; other site 707235002256 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 707235002257 short chain dehydrogenase; Provisional; Region: PRK05876 707235002258 classical (c) SDRs; Region: SDR_c; cd05233 707235002259 NAD(P) binding site [chemical binding]; other site 707235002260 active site 707235002261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235002262 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 707235002263 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 707235002264 dimer interface [polypeptide binding]; other site 707235002265 PYR/PP interface [polypeptide binding]; other site 707235002266 TPP binding site [chemical binding]; other site 707235002267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 707235002268 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 707235002269 TPP-binding site [chemical binding]; other site 707235002270 dimer interface [polypeptide binding]; other site 707235002271 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 707235002272 putative hydrophobic ligand binding site [chemical binding]; other site 707235002273 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 707235002274 CoA-transferase family III; Region: CoA_transf_3; pfam02515 707235002275 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 707235002276 putative hydrophobic ligand binding site [chemical binding]; other site 707235002277 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 707235002278 putative hydrophobic ligand binding site [chemical binding]; other site 707235002279 aminotransferase; Validated; Region: PRK07777 707235002280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235002281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235002282 homodimer interface [polypeptide binding]; other site 707235002283 catalytic residue [active] 707235002284 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 707235002285 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235002286 dimer interface [polypeptide binding]; other site 707235002287 active site 707235002288 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 707235002289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235002290 substrate binding site [chemical binding]; other site 707235002291 oxyanion hole (OAH) forming residues; other site 707235002292 trimer interface [polypeptide binding]; other site 707235002293 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 707235002294 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 707235002295 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 707235002296 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 707235002297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235002298 ATP binding site [chemical binding]; other site 707235002299 putative Mg++ binding site [ion binding]; other site 707235002300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235002301 nucleotide binding region [chemical binding]; other site 707235002302 ATP-binding site [chemical binding]; other site 707235002303 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 707235002304 WYL domain; Region: WYL; pfam13280 707235002305 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 707235002306 trimer interface [polypeptide binding]; other site 707235002307 dimer interface [polypeptide binding]; other site 707235002308 putative active site [active] 707235002309 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 707235002310 MPT binding site; other site 707235002311 trimer interface [polypeptide binding]; other site 707235002312 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 707235002313 MoaE homodimer interface [polypeptide binding]; other site 707235002314 MoaD interaction [polypeptide binding]; other site 707235002315 active site residues [active] 707235002316 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 707235002317 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 707235002318 MoaE interaction surface [polypeptide binding]; other site 707235002319 MoeB interaction surface [polypeptide binding]; other site 707235002320 thiocarboxylated glycine; other site 707235002321 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 707235002322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235002323 FeS/SAM binding site; other site 707235002324 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 707235002325 hypothetical protein; Provisional; Region: PRK11770 707235002326 Domain of unknown function (DUF307); Region: DUF307; pfam03733 707235002327 Domain of unknown function (DUF307); Region: DUF307; pfam03733 707235002328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 707235002329 DNA-binding site [nucleotide binding]; DNA binding site 707235002330 RNA-binding motif; other site 707235002331 PE family; Region: PE; pfam00934 707235002332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235002333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235002334 active site 707235002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 707235002336 FIST N domain; Region: FIST; pfam08495 707235002337 FIST C domain; Region: FIST_C; pfam10442 707235002338 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 707235002339 H+ Antiporter protein; Region: 2A0121; TIGR00900 707235002340 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 707235002341 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235002342 PPE family; Region: PPE; pfam00823 707235002343 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235002344 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235002345 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 707235002346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235002347 MarR family; Region: MarR; pfam01047 707235002348 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 707235002349 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 707235002350 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 707235002351 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 707235002352 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 707235002353 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 707235002354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235002355 catalytic residue [active] 707235002356 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 707235002357 Ferredoxin [Energy production and conversion]; Region: COG1146 707235002358 4Fe-4S binding domain; Region: Fer4; pfam00037 707235002359 ferredoxin-NADP+ reductase; Region: PLN02852 707235002360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235002361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 707235002362 putative dimer interface [polypeptide binding]; other site 707235002363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235002364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 707235002365 putative catalytic site [active] 707235002366 putative phosphate binding site [ion binding]; other site 707235002367 putative metal binding site [ion binding]; other site 707235002368 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 707235002369 dimer interface [polypeptide binding]; other site 707235002370 Citrate synthase; Region: Citrate_synt; pfam00285 707235002371 active site 707235002372 citrylCoA binding site [chemical binding]; other site 707235002373 oxalacetate/citrate binding site [chemical binding]; other site 707235002374 coenzyme A binding site [chemical binding]; other site 707235002375 catalytic triad [active] 707235002376 Predicted ATPase [General function prediction only]; Region: COG3903 707235002377 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235002378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235002379 DNA binding residues [nucleotide binding] 707235002380 dimerization interface [polypeptide binding]; other site 707235002381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235002382 cyclase homology domain; Region: CHD; cd07302 707235002383 nucleotidyl binding site; other site 707235002384 metal binding site [ion binding]; metal-binding site 707235002385 dimer interface [polypeptide binding]; other site 707235002386 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235002387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235002388 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235002389 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235002390 AAA ATPase domain; Region: AAA_16; pfam13191 707235002391 Predicted ATPase [General function prediction only]; Region: COG3903 707235002392 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235002393 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235002394 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 707235002395 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 707235002396 dimer interface [polypeptide binding]; other site 707235002397 active site 707235002398 citrylCoA binding site [chemical binding]; other site 707235002399 NADH binding [chemical binding]; other site 707235002400 cationic pore residues; other site 707235002401 oxalacetate/citrate binding site [chemical binding]; other site 707235002402 coenzyme A binding site [chemical binding]; other site 707235002403 catalytic triad [active] 707235002404 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 707235002405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235002406 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 707235002407 BON domain; Region: BON; pfam04972 707235002408 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 707235002409 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 707235002410 ligand binding site [chemical binding]; other site 707235002411 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 707235002412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235002413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235002414 dimerization interface [polypeptide binding]; other site 707235002415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235002416 dimer interface [polypeptide binding]; other site 707235002417 phosphorylation site [posttranslational modification] 707235002418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235002419 Mg2+ binding site [ion binding]; other site 707235002420 G-X-G motif; other site 707235002421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235002422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002423 active site 707235002424 phosphorylation site [posttranslational modification] 707235002425 intermolecular recognition site; other site 707235002426 dimerization interface [polypeptide binding]; other site 707235002427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002428 DNA binding site [nucleotide binding] 707235002429 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 707235002430 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 707235002431 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235002432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235002433 substrate binding site [chemical binding]; other site 707235002434 oxyanion hole (OAH) forming residues; other site 707235002435 trimer interface [polypeptide binding]; other site 707235002436 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 707235002437 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 707235002438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235002439 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235002440 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 707235002441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 707235002442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235002443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235002444 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 707235002445 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 707235002446 hydrophobic ligand binding site; other site 707235002447 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 707235002448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235002449 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 707235002450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235002451 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 707235002452 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 707235002453 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 707235002454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235002455 active site 707235002456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235002457 PPE family; Region: PPE; pfam00823 707235002458 PE family; Region: PE; pfam00934 707235002459 BCCT family transporter; Region: BCCT; pfam02028 707235002460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 707235002461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235002462 Coenzyme A binding pocket [chemical binding]; other site 707235002463 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235002464 MULE transposase domain; Region: MULE; pfam10551 707235002465 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235002466 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 707235002467 catalytic residues [active] 707235002468 catalytic nucleophile [active] 707235002469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235002470 Probable transposase; Region: OrfB_IS605; pfam01385 707235002471 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 707235002472 putative active site pocket [active] 707235002473 dimerization interface [polypeptide binding]; other site 707235002474 putative catalytic residue [active] 707235002475 Phage-related replication protein [General function prediction only]; Region: COG4195 707235002476 manganese transport protein MntH; Reviewed; Region: PRK00701 707235002477 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 707235002478 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 707235002479 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 707235002480 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 707235002481 short chain dehydrogenase; Provisional; Region: PRK07814 707235002482 classical (c) SDRs; Region: SDR_c; cd05233 707235002483 NAD(P) binding site [chemical binding]; other site 707235002484 active site 707235002485 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 707235002486 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 707235002487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235002488 dimer interface [polypeptide binding]; other site 707235002489 conserved gate region; other site 707235002490 putative PBP binding loops; other site 707235002491 ABC-ATPase subunit interface; other site 707235002492 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 707235002493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235002494 dimer interface [polypeptide binding]; other site 707235002495 conserved gate region; other site 707235002496 putative PBP binding loops; other site 707235002497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 707235002498 ABC-ATPase subunit interface; other site 707235002499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235002500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235002501 active site 707235002502 ATP binding site [chemical binding]; other site 707235002503 substrate binding site [chemical binding]; other site 707235002504 activation loop (A-loop); other site 707235002505 Uncharacterized conserved protein [Function unknown]; Region: COG3391 707235002506 NHL repeat; Region: NHL; pfam01436 707235002507 NHL repeat; Region: NHL; pfam01436 707235002508 NHL repeat; Region: NHL; pfam01436 707235002509 NHL repeat; Region: NHL; pfam01436 707235002510 NHL repeat; Region: NHL; pfam01436 707235002511 PBP superfamily domain; Region: PBP_like_2; cl17296 707235002512 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 707235002513 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 707235002514 Walker A/P-loop; other site 707235002515 ATP binding site [chemical binding]; other site 707235002516 Q-loop/lid; other site 707235002517 ABC transporter signature motif; other site 707235002518 Walker B; other site 707235002519 D-loop; other site 707235002520 H-loop/switch region; other site 707235002521 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 707235002522 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 707235002523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235002524 dimer interface [polypeptide binding]; other site 707235002525 conserved gate region; other site 707235002526 putative PBP binding loops; other site 707235002527 ABC-ATPase subunit interface; other site 707235002528 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 707235002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235002530 dimer interface [polypeptide binding]; other site 707235002531 conserved gate region; other site 707235002532 putative PBP binding loops; other site 707235002533 ABC-ATPase subunit interface; other site 707235002534 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 707235002535 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 707235002536 putative DNA binding site [nucleotide binding]; other site 707235002537 putative homodimer interface [polypeptide binding]; other site 707235002538 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 707235002539 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 707235002540 nucleotide binding site [chemical binding]; other site 707235002541 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 707235002542 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 707235002543 active site 707235002544 DNA binding site [nucleotide binding] 707235002545 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 707235002546 DNA binding site [nucleotide binding] 707235002547 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 707235002548 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 707235002549 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 707235002550 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 707235002551 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235002552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235002553 anti sigma factor interaction site; other site 707235002554 regulatory phosphorylation site [posttranslational modification]; other site 707235002555 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235002556 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 707235002557 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 707235002558 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 707235002559 short chain dehydrogenase; Provisional; Region: PRK08251 707235002560 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 707235002561 putative NAD(P) binding site [chemical binding]; other site 707235002562 active site 707235002563 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 707235002564 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 707235002565 active site 707235002566 dimer interface [polypeptide binding]; other site 707235002567 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 707235002568 dimer interface [polypeptide binding]; other site 707235002569 active site 707235002570 hypothetical protein; Provisional; Region: PRK07857 707235002571 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 707235002572 Part of AAA domain; Region: AAA_19; pfam13245 707235002573 Family description; Region: UvrD_C_2; pfam13538 707235002574 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 707235002575 Peptidase family M23; Region: Peptidase_M23; pfam01551 707235002576 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 707235002577 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 707235002578 CoA-ligase; Region: Ligase_CoA; pfam00549 707235002579 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 707235002580 CoA binding domain; Region: CoA_binding; smart00881 707235002581 CoA-ligase; Region: Ligase_CoA; pfam00549 707235002582 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 707235002583 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235002584 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 707235002585 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 707235002586 active site 707235002587 substrate binding site [chemical binding]; other site 707235002588 cosubstrate binding site; other site 707235002589 catalytic site [active] 707235002590 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 707235002591 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 707235002592 purine monophosphate binding site [chemical binding]; other site 707235002593 dimer interface [polypeptide binding]; other site 707235002594 putative catalytic residues [active] 707235002595 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 707235002596 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 707235002597 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 707235002598 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 707235002599 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 707235002600 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 707235002601 metal ion-dependent adhesion site (MIDAS); other site 707235002602 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 707235002603 homotetrameric interface [polypeptide binding]; other site 707235002604 putative active site [active] 707235002605 metal binding site [ion binding]; metal-binding site 707235002606 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 707235002607 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 707235002608 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 707235002609 putative homodimer interface [polypeptide binding]; other site 707235002610 putative homotetramer interface [polypeptide binding]; other site 707235002611 allosteric switch controlling residues; other site 707235002612 putative metal binding site [ion binding]; other site 707235002613 putative homodimer-homodimer interface [polypeptide binding]; other site 707235002614 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 707235002615 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 707235002616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235002617 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235002618 enoyl-CoA hydratase; Provisional; Region: PRK07827 707235002619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235002620 substrate binding site [chemical binding]; other site 707235002621 oxyanion hole (OAH) forming residues; other site 707235002622 trimer interface [polypeptide binding]; other site 707235002623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235002624 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 707235002625 active site 707235002626 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 707235002627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235002628 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235002629 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 707235002630 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707235002631 carboxyltransferase (CT) interaction site; other site 707235002632 biotinylation site [posttranslational modification]; other site 707235002633 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 707235002634 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 707235002635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235002636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235002637 active site 707235002638 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 707235002639 PE family; Region: PE; pfam00934 707235002640 PE family; Region: PE; pfam00934 707235002641 Uncharacterized conserved protein [Function unknown]; Region: COG3391 707235002642 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 707235002643 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 707235002644 PE family; Region: PE; pfam00934 707235002645 Uncharacterized conserved protein [Function unknown]; Region: COG3391 707235002646 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 707235002647 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 707235002648 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 707235002649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235002650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002651 active site 707235002652 phosphorylation site [posttranslational modification] 707235002653 intermolecular recognition site; other site 707235002654 dimerization interface [polypeptide binding]; other site 707235002655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002656 DNA binding site [nucleotide binding] 707235002657 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 707235002658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235002659 dimerization interface [polypeptide binding]; other site 707235002660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235002661 dimer interface [polypeptide binding]; other site 707235002662 phosphorylation site [posttranslational modification] 707235002663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235002664 ATP binding site [chemical binding]; other site 707235002665 Mg2+ binding site [ion binding]; other site 707235002666 G-X-G motif; other site 707235002667 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 707235002668 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707235002669 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 707235002670 MPT binding site; other site 707235002671 trimer interface [polypeptide binding]; other site 707235002672 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 707235002673 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 707235002674 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707235002675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 707235002676 Walker A/P-loop; other site 707235002677 ATP binding site [chemical binding]; other site 707235002678 Q-loop/lid; other site 707235002679 ABC transporter signature motif; other site 707235002680 Walker B; other site 707235002681 D-loop; other site 707235002682 H-loop/switch region; other site 707235002683 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 707235002684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 707235002685 FtsX-like permease family; Region: FtsX; pfam02687 707235002686 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 707235002687 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 707235002688 FtsX-like permease family; Region: FtsX; pfam02687 707235002689 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 707235002690 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707235002691 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707235002692 substrate binding pocket [chemical binding]; other site 707235002693 chain length determination region; other site 707235002694 substrate-Mg2+ binding site; other site 707235002695 catalytic residues [active] 707235002696 aspartate-rich region 1; other site 707235002697 active site lid residues [active] 707235002698 aspartate-rich region 2; other site 707235002699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 707235002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 707235002701 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 707235002702 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 707235002703 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 707235002704 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 707235002705 active site 707235002706 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 707235002707 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 707235002708 dimer interface [polypeptide binding]; other site 707235002709 putative functional site; other site 707235002710 putative MPT binding site; other site 707235002711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 707235002712 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 707235002713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235002714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235002715 ligand binding site [chemical binding]; other site 707235002716 flexible hinge region; other site 707235002717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 707235002718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235002719 Coenzyme A binding pocket [chemical binding]; other site 707235002720 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 707235002721 arginine deiminase; Provisional; Region: PRK01388 707235002722 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 707235002723 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 707235002724 Predicted methyltransferases [General function prediction only]; Region: COG0313 707235002725 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 707235002726 putative SAM binding site [chemical binding]; other site 707235002727 putative homodimer interface [polypeptide binding]; other site 707235002728 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 707235002729 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 707235002730 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 707235002731 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 707235002732 active site 707235002733 HIGH motif; other site 707235002734 KMSKS motif; other site 707235002735 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 707235002736 tRNA binding surface [nucleotide binding]; other site 707235002737 anticodon binding site; other site 707235002738 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 707235002739 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 707235002740 active site 707235002741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 707235002742 Domain of unknown function (DUF348); Region: DUF348; pfam03990 707235002743 Domain of unknown function (DUF348); Region: DUF348; pfam03990 707235002744 G5 domain; Region: G5; pfam07501 707235002745 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 707235002746 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 707235002747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235002748 S-adenosylmethionine binding site [chemical binding]; other site 707235002749 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 707235002750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235002751 acyl-activating enzyme (AAE) consensus motif; other site 707235002752 AMP binding site [chemical binding]; other site 707235002753 active site 707235002754 CoA binding site [chemical binding]; other site 707235002755 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 707235002756 putative active site [active] 707235002757 catalytic residue [active] 707235002758 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 707235002759 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 707235002760 5S rRNA interface [nucleotide binding]; other site 707235002761 CTC domain interface [polypeptide binding]; other site 707235002762 L16 interface [polypeptide binding]; other site 707235002763 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 707235002764 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 707235002765 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 707235002766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235002767 active site 707235002768 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 707235002769 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 707235002770 Substrate binding site; other site 707235002771 Mg++ binding site; other site 707235002772 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 707235002773 active site 707235002774 substrate binding site [chemical binding]; other site 707235002775 CoA binding site [chemical binding]; other site 707235002776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235002777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235002778 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 707235002779 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 707235002780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235002781 ATP binding site [chemical binding]; other site 707235002782 putative Mg++ binding site [ion binding]; other site 707235002783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235002784 nucleotide binding region [chemical binding]; other site 707235002785 ATP-binding site [chemical binding]; other site 707235002786 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 707235002787 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 707235002788 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 707235002789 homodimer interface [polypeptide binding]; other site 707235002790 metal binding site [ion binding]; metal-binding site 707235002791 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 707235002792 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 707235002793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 707235002794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 707235002795 enolase; Provisional; Region: eno; PRK00077 707235002796 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 707235002797 dimer interface [polypeptide binding]; other site 707235002798 metal binding site [ion binding]; metal-binding site 707235002799 substrate binding pocket [chemical binding]; other site 707235002800 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 707235002801 Septum formation initiator; Region: DivIC; pfam04977 707235002802 Uncharacterized conserved protein [Function unknown]; Region: COG1507 707235002803 exopolyphosphatase; Region: exo_poly_only; TIGR03706 707235002804 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 707235002805 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 707235002806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002807 active site 707235002808 phosphorylation site [posttranslational modification] 707235002809 intermolecular recognition site; other site 707235002810 dimerization interface [polypeptide binding]; other site 707235002811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002812 DNA binding site [nucleotide binding] 707235002813 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 707235002814 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 707235002815 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 707235002816 Ligand Binding Site [chemical binding]; other site 707235002817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235002818 dimer interface [polypeptide binding]; other site 707235002819 phosphorylation site [posttranslational modification] 707235002820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235002821 ATP binding site [chemical binding]; other site 707235002822 Mg2+ binding site [ion binding]; other site 707235002823 G-X-G motif; other site 707235002824 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 707235002825 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 707235002826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235002827 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235002828 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 707235002829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235002830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235002831 dimer interface [polypeptide binding]; other site 707235002832 phosphorylation site [posttranslational modification] 707235002833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235002834 ATP binding site [chemical binding]; other site 707235002835 Mg2+ binding site [ion binding]; other site 707235002836 G-X-G motif; other site 707235002837 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235002838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235002839 active site 707235002840 phosphorylation site [posttranslational modification] 707235002841 intermolecular recognition site; other site 707235002842 dimerization interface [polypeptide binding]; other site 707235002843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235002844 DNA binding site [nucleotide binding] 707235002845 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 707235002846 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 707235002847 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 707235002848 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235002849 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 707235002850 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235002851 PPE family; Region: PPE; pfam00823 707235002852 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235002853 PE family; Region: PE; pfam00934 707235002854 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235002855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 707235002856 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 707235002857 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 707235002858 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 707235002859 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707235002860 Predicted transcriptional regulator [Transcription]; Region: COG5340 707235002861 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235002862 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 707235002863 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235002864 MULE transposase domain; Region: MULE; pfam10551 707235002865 Transcriptional regulators [Transcription]; Region: MarR; COG1846 707235002866 MarR family; Region: MarR_2; pfam12802 707235002867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235002868 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235002869 NAD(P) binding site [chemical binding]; other site 707235002870 active site 707235002871 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 707235002872 Helix-turn-helix domain; Region: HTH_17; pfam12728 707235002873 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235002874 Domain of unknown function (DUF427); Region: DUF427; cl00998 707235002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 707235002876 Uncharacterized conserved protein [Function unknown]; Region: COG3391 707235002877 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 707235002878 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 707235002879 dimer interface [polypeptide binding]; other site 707235002880 acyl-activating enzyme (AAE) consensus motif; other site 707235002881 putative active site [active] 707235002882 AMP binding site [chemical binding]; other site 707235002883 putative CoA binding site [chemical binding]; other site 707235002884 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 707235002885 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 707235002886 hydrophobic ligand binding site; other site 707235002887 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 707235002888 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 707235002889 putative active site [active] 707235002890 putative dimer interface [polypeptide binding]; other site 707235002891 Patatin-like phospholipase; Region: Patatin; pfam01734 707235002892 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 707235002893 nucleophile elbow; other site 707235002894 hypothetical protein; Provisional; Region: PRK10279 707235002895 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 707235002896 active site 707235002897 nucleophile elbow; other site 707235002898 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 707235002899 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 707235002900 active site residue [active] 707235002901 PE family; Region: PE; pfam00934 707235002902 PE family; Region: PE; pfam00934 707235002903 Predicted membrane protein [Function unknown]; Region: COG4425 707235002904 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 707235002905 enoyl-CoA hydratase; Provisional; Region: PRK05862 707235002906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235002907 substrate binding site [chemical binding]; other site 707235002908 oxyanion hole (OAH) forming residues; other site 707235002909 trimer interface [polypeptide binding]; other site 707235002910 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 707235002911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235002912 substrate binding site [chemical binding]; other site 707235002913 oxyanion hole (OAH) forming residues; other site 707235002914 trimer interface [polypeptide binding]; other site 707235002915 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 707235002916 Predicted membrane protein [Function unknown]; Region: COG4760 707235002917 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235002918 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 707235002919 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 707235002920 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235002921 dimer interface [polypeptide binding]; other site 707235002922 active site 707235002923 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 707235002924 active site 707235002925 catalytic triad [active] 707235002926 oxyanion hole [active] 707235002927 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 707235002928 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 707235002929 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 707235002930 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 707235002931 dimer interface [polypeptide binding]; other site 707235002932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235002933 catalytic residue [active] 707235002934 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 707235002935 RDD family; Region: RDD; pfam06271 707235002936 cystathionine gamma-synthase; Provisional; Region: PRK07811 707235002937 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 707235002938 homodimer interface [polypeptide binding]; other site 707235002939 substrate-cofactor binding pocket; other site 707235002940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235002941 catalytic residue [active] 707235002942 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 707235002943 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 707235002944 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 707235002945 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 707235002946 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 707235002947 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 707235002948 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 707235002949 catalytic residues [active] 707235002950 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 707235002951 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 707235002952 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 707235002953 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 707235002954 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 707235002955 catalytic residue [active] 707235002956 putative FPP diphosphate binding site; other site 707235002957 putative FPP binding hydrophobic cleft; other site 707235002958 dimer interface [polypeptide binding]; other site 707235002959 putative IPP diphosphate binding site; other site 707235002960 PE family; Region: PE; pfam00934 707235002961 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 707235002962 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 707235002963 putative IPP diphosphate binding site; other site 707235002964 PE family; Region: PE; pfam00934 707235002965 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 707235002966 PE family; Region: PE; pfam00934 707235002967 pantothenate kinase; Provisional; Region: PRK05439 707235002968 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 707235002969 ATP-binding site [chemical binding]; other site 707235002970 CoA-binding site [chemical binding]; other site 707235002971 Mg2+-binding site [ion binding]; other site 707235002972 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 707235002973 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 707235002974 dimer interface [polypeptide binding]; other site 707235002975 active site 707235002976 glycine-pyridoxal phosphate binding site [chemical binding]; other site 707235002977 folate binding site [chemical binding]; other site 707235002978 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 707235002979 dinuclear metal binding motif [ion binding]; other site 707235002980 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 707235002981 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 707235002982 putative active site [active] 707235002983 PhoH-like protein; Region: PhoH; pfam02562 707235002984 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 707235002985 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 707235002986 NodB motif; other site 707235002987 active site 707235002988 catalytic site [active] 707235002989 metal binding site [ion binding]; metal-binding site 707235002990 fumarate hydratase; Reviewed; Region: fumC; PRK00485 707235002991 Class II fumarases; Region: Fumarase_classII; cd01362 707235002992 active site 707235002993 tetramer interface [polypeptide binding]; other site 707235002994 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 707235002995 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 707235002996 putative active site [active] 707235002997 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 707235002998 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 707235002999 Domain of unknown function DUF20; Region: UPF0118; pfam01594 707235003000 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235003001 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 707235003002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235003003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235003004 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 707235003005 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 707235003006 putative NAD(P) binding site [chemical binding]; other site 707235003007 active site 707235003008 putative substrate binding site [chemical binding]; other site 707235003009 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 707235003010 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 707235003011 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 707235003012 generic binding surface II; other site 707235003013 generic binding surface I; other site 707235003014 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 707235003015 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 707235003016 Yip1 domain; Region: Yip1; pfam04893 707235003017 GTP-binding protein YchF; Reviewed; Region: PRK09601 707235003018 YchF GTPase; Region: YchF; cd01900 707235003019 G1 box; other site 707235003020 GTP/Mg2+ binding site [chemical binding]; other site 707235003021 Switch I region; other site 707235003022 G2 box; other site 707235003023 Switch II region; other site 707235003024 G3 box; other site 707235003025 G4 box; other site 707235003026 G5 box; other site 707235003027 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 707235003028 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 707235003029 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 707235003030 putative active site [active] 707235003031 Uncharacterized conserved protein [Function unknown]; Region: COG1359 707235003032 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003033 cyclase homology domain; Region: CHD; cd07302 707235003034 nucleotidyl binding site; other site 707235003035 metal binding site [ion binding]; metal-binding site 707235003036 dimer interface [polypeptide binding]; other site 707235003037 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 707235003038 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 707235003039 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 707235003040 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 707235003041 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 707235003042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235003043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235003044 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235003045 pyruvate phosphate dikinase; Provisional; Region: PRK05878 707235003046 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 707235003047 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 707235003048 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235003049 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235003050 active site 707235003051 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235003052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235003053 non-specific DNA binding site [nucleotide binding]; other site 707235003054 salt bridge; other site 707235003055 sequence-specific DNA binding site [nucleotide binding]; other site 707235003056 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 707235003057 Domain of unknown function (DUF955); Region: DUF955; pfam06114 707235003058 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 707235003059 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 707235003060 citrate synthase; Provisional; Region: PRK14033 707235003061 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 707235003062 oxalacetate binding site [chemical binding]; other site 707235003063 citrylCoA binding site [chemical binding]; other site 707235003064 coenzyme A binding site [chemical binding]; other site 707235003065 catalytic triad [active] 707235003066 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 707235003067 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 707235003068 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 707235003069 THF binding site; other site 707235003070 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 707235003071 substrate binding site [chemical binding]; other site 707235003072 THF binding site; other site 707235003073 zinc-binding site [ion binding]; other site 707235003074 PPE family; Region: PPE; pfam00823 707235003075 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 707235003076 active site 707235003077 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235003078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235003079 substrate binding site [chemical binding]; other site 707235003080 oxyanion hole (OAH) forming residues; other site 707235003081 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 707235003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 707235003083 CAAX protease self-immunity; Region: Abi; pfam02517 707235003084 enoyl-CoA hydratase; Provisional; Region: PRK06688 707235003085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 707235003086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235003087 trimer interface [polypeptide binding]; other site 707235003088 enoyl-CoA hydratase; Provisional; Region: PRK06688 707235003089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235003090 substrate binding site [chemical binding]; other site 707235003091 oxyanion hole (OAH) forming residues; other site 707235003092 trimer interface [polypeptide binding]; other site 707235003093 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 707235003094 CoA-transferase family III; Region: CoA_transf_3; pfam02515 707235003095 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 707235003096 NAD binding site [chemical binding]; other site 707235003097 homodimer interface [polypeptide binding]; other site 707235003098 homotetramer interface [polypeptide binding]; other site 707235003099 active site 707235003100 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235003101 MMPL family; Region: MMPL; pfam03176 707235003102 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235003103 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235003104 active site 707235003105 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 707235003106 NAD-dependent deacetylase; Provisional; Region: PRK00481 707235003107 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 707235003108 NAD+ binding site [chemical binding]; other site 707235003109 substrate binding site [chemical binding]; other site 707235003110 Zn binding site [ion binding]; other site 707235003111 Predicted transcriptional regulators [Transcription]; Region: COG1725 707235003112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235003113 DNA-binding site [nucleotide binding]; DNA binding site 707235003114 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235003115 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 707235003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 707235003117 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 707235003118 uncharacterized HhH-GPD family protein; Region: TIGR03252 707235003119 minor groove reading motif; other site 707235003120 helix-hairpin-helix signature motif; other site 707235003121 mannosyltransferase; Provisional; Region: pimE; PRK13375 707235003122 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 707235003123 aromatic arch; other site 707235003124 DCoH dimer interaction site [polypeptide binding]; other site 707235003125 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 707235003126 DCoH tetramer interaction site [polypeptide binding]; other site 707235003127 substrate binding site [chemical binding]; other site 707235003128 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 707235003129 active site 707235003130 8-oxo-dGMP binding site [chemical binding]; other site 707235003131 nudix motif; other site 707235003132 metal binding site [ion binding]; metal-binding site 707235003133 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 707235003134 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 707235003135 [4Fe-4S] binding site [ion binding]; other site 707235003136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235003137 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235003138 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235003139 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 707235003140 molybdopterin cofactor binding site; other site 707235003141 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 707235003142 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 707235003143 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 707235003144 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 707235003145 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 707235003146 G1 box; other site 707235003147 putative GEF interaction site [polypeptide binding]; other site 707235003148 GTP/Mg2+ binding site [chemical binding]; other site 707235003149 Switch I region; other site 707235003150 G2 box; other site 707235003151 G3 box; other site 707235003152 Switch II region; other site 707235003153 G4 box; other site 707235003154 G5 box; other site 707235003155 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 707235003156 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 707235003157 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 707235003158 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 707235003159 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 707235003160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235003161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235003162 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235003163 PPE family; Region: PPE; pfam00823 707235003164 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235003165 PE family; Region: PE; pfam00934 707235003166 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 707235003167 PE family; Region: PE; pfam00934 707235003168 FO synthase; Reviewed; Region: fbiC; PRK09234 707235003169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235003170 FeS/SAM binding site; other site 707235003171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235003172 FeS/SAM binding site; other site 707235003173 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 707235003174 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 707235003175 active site 707235003176 FMN binding site [chemical binding]; other site 707235003177 2,4-decadienoyl-CoA binding site; other site 707235003178 catalytic residue [active] 707235003179 4Fe-4S cluster binding site [ion binding]; other site 707235003180 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 707235003181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235003182 Predicted transcriptional regulators [Transcription]; Region: COG1695 707235003183 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 707235003184 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 707235003185 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 707235003186 4Fe-4S binding domain; Region: Fer4; pfam00037 707235003187 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 707235003188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235003190 homodimer interface [polypeptide binding]; other site 707235003191 catalytic residue [active] 707235003192 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 707235003193 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 707235003194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 707235003195 ATP binding site [chemical binding]; other site 707235003196 putative Mg++ binding site [ion binding]; other site 707235003197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 707235003198 ATP-binding site [chemical binding]; other site 707235003199 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235003200 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235003201 active site 707235003202 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235003203 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235003204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235003205 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235003206 Enoylreductase; Region: PKS_ER; smart00829 707235003207 NAD(P) binding site [chemical binding]; other site 707235003208 KR domain; Region: KR; pfam08659 707235003209 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235003210 putative NADP binding site [chemical binding]; other site 707235003211 active site 707235003212 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235003213 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235003214 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235003215 PE-PPE domain; Region: PE-PPE; pfam08237 707235003216 acyl-CoA synthetase; Validated; Region: PRK05850 707235003217 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235003218 acyl-activating enzyme (AAE) consensus motif; other site 707235003219 active site 707235003220 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235003221 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 707235003222 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 707235003223 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 707235003224 Glutamate binding site [chemical binding]; other site 707235003225 NAD binding site [chemical binding]; other site 707235003226 catalytic residues [active] 707235003227 Proline dehydrogenase; Region: Pro_dh; pfam01619 707235003228 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 707235003229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235003230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235003231 DNA binding residues [nucleotide binding] 707235003232 haloalkane dehalogenase; Provisional; Region: PRK03204 707235003233 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 707235003234 catalytic site [active] 707235003235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235003236 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 707235003237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235003238 PGAP1-like protein; Region: PGAP1; pfam07819 707235003239 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235003240 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 707235003241 PE family; Region: PE; pfam00934 707235003242 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235003243 PPE family; Region: PPE; pfam00823 707235003244 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235003245 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 707235003246 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235003247 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235003248 MULE transposase domain; Region: MULE; pfam10551 707235003249 metabolite-proton symporter; Region: 2A0106; TIGR00883 707235003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235003251 putative substrate translocation pore; other site 707235003252 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 707235003253 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 707235003254 putative trimer interface [polypeptide binding]; other site 707235003255 putative CoA binding site [chemical binding]; other site 707235003256 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 707235003257 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 707235003258 metal binding site [ion binding]; metal-binding site 707235003259 putative dimer interface [polypeptide binding]; other site 707235003260 TIGR00730 family protein; Region: TIGR00730 707235003261 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 707235003262 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 707235003263 acyl-activating enzyme (AAE) consensus motif; other site 707235003264 putative AMP binding site [chemical binding]; other site 707235003265 putative active site [active] 707235003266 putative CoA binding site [chemical binding]; other site 707235003267 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 707235003268 dihydropteroate synthase; Region: DHPS; TIGR01496 707235003269 substrate binding pocket [chemical binding]; other site 707235003270 dimer interface [polypeptide binding]; other site 707235003271 inhibitor binding site; inhibition site 707235003272 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 707235003273 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 707235003274 DivIVA domain; Region: DivI1A_domain; TIGR03544 707235003275 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 707235003276 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 707235003277 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 707235003278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 707235003279 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 707235003280 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 707235003281 ligand binding site; other site 707235003282 oligomer interface; other site 707235003283 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 707235003284 dimer interface [polypeptide binding]; other site 707235003285 N-terminal domain interface [polypeptide binding]; other site 707235003286 sulfate 1 binding site; other site 707235003287 PE family; Region: PE; pfam00934 707235003288 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 707235003289 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 707235003290 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 707235003291 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 707235003292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 707235003293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 707235003294 Walker A/P-loop; other site 707235003295 ATP binding site [chemical binding]; other site 707235003296 Q-loop/lid; other site 707235003297 ABC transporter signature motif; other site 707235003298 Walker B; other site 707235003299 D-loop; other site 707235003300 H-loop/switch region; other site 707235003301 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 707235003302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235003303 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 707235003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235003305 S-adenosylmethionine binding site [chemical binding]; other site 707235003306 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 707235003307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235003308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235003309 DNA binding residues [nucleotide binding] 707235003310 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 707235003311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707235003312 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 707235003313 protein binding site [polypeptide binding]; other site 707235003314 sec-independent translocase; Provisional; Region: PRK03100 707235003315 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 707235003316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235003317 active site 707235003318 motif I; other site 707235003319 motif II; other site 707235003320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235003321 Predicted membrane protein [Function unknown]; Region: COG3428 707235003322 Bacterial PH domain; Region: DUF304; pfam03703 707235003323 Uncharacterized conserved protein [Function unknown]; Region: COG3402 707235003324 Domain of unknown function DUF59; Region: DUF59; cl00941 707235003325 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 707235003326 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 707235003327 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 707235003328 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 707235003329 N-acetyl-D-glucosamine binding site [chemical binding]; other site 707235003330 catalytic residue [active] 707235003331 Predicted membrane protein [Function unknown]; Region: COG4420 707235003332 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 707235003333 MgtE intracellular N domain; Region: MgtE_N; smart00924 707235003334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 707235003335 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 707235003336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 707235003337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 707235003338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235003339 dimer interface [polypeptide binding]; other site 707235003340 conserved gate region; other site 707235003341 putative PBP binding loops; other site 707235003342 ABC-ATPase subunit interface; other site 707235003343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 707235003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235003345 dimer interface [polypeptide binding]; other site 707235003346 conserved gate region; other site 707235003347 ABC-ATPase subunit interface; other site 707235003348 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 707235003349 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 707235003350 Walker A/P-loop; other site 707235003351 ATP binding site [chemical binding]; other site 707235003352 Q-loop/lid; other site 707235003353 ABC transporter signature motif; other site 707235003354 Walker B; other site 707235003355 D-loop; other site 707235003356 H-loop/switch region; other site 707235003357 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 707235003358 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 707235003359 oligomer interface [polypeptide binding]; other site 707235003360 metal binding site [ion binding]; metal-binding site 707235003361 metal binding site [ion binding]; metal-binding site 707235003362 putative Cl binding site [ion binding]; other site 707235003363 basic sphincter; other site 707235003364 hydrophobic gate; other site 707235003365 periplasmic entrance; other site 707235003366 malate dehydrogenase; Provisional; Region: PRK05442 707235003367 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 707235003368 NAD(P) binding site [chemical binding]; other site 707235003369 dimer interface [polypeptide binding]; other site 707235003370 malate binding site [chemical binding]; other site 707235003371 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235003372 PE family; Region: PE; pfam00934 707235003373 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 707235003374 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 707235003375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235003376 NAD(P) binding site [chemical binding]; other site 707235003377 active site 707235003378 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 707235003379 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 707235003380 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 707235003381 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707235003382 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 707235003383 TPP-binding site [chemical binding]; other site 707235003384 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 707235003385 dimer interface [polypeptide binding]; other site 707235003386 PYR/PP interface [polypeptide binding]; other site 707235003387 TPP binding site [chemical binding]; other site 707235003388 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235003389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235003390 putative substrate translocation pore; other site 707235003391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235003392 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 707235003393 RNase_H superfamily; Region: RNase_H_2; pfam13482 707235003394 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 707235003395 Part of AAA domain; Region: AAA_19; pfam13245 707235003396 AAA domain; Region: AAA_12; pfam13087 707235003397 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 707235003398 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 707235003399 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 707235003400 ATP binding site [chemical binding]; other site 707235003401 Mg++ binding site [ion binding]; other site 707235003402 motif III; other site 707235003403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235003404 nucleotide binding region [chemical binding]; other site 707235003405 ATP-binding site [chemical binding]; other site 707235003406 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 707235003407 putative RNA binding site [nucleotide binding]; other site 707235003408 Acyltransferase family; Region: Acyl_transf_3; pfam01757 707235003409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235003410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235003411 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235003412 FAD binding domain; Region: FAD_binding_4; pfam01565 707235003413 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 707235003414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235003415 H+ Antiporter protein; Region: 2A0121; TIGR00900 707235003416 putative substrate translocation pore; other site 707235003417 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 707235003418 Fe-S cluster binding site [ion binding]; other site 707235003419 DNA binding site [nucleotide binding] 707235003420 active site 707235003421 hypothetical protein; Validated; Region: PRK05868 707235003422 hypothetical protein; Provisional; Region: PRK07236 707235003423 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 707235003424 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235003425 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 707235003426 HIT family signature motif; other site 707235003427 catalytic residue [active] 707235003428 amidase; Provisional; Region: PRK12470 707235003429 Amidase; Region: Amidase; pfam01425 707235003430 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003431 cyclase homology domain; Region: CHD; cd07302 707235003432 nucleotidyl binding site; other site 707235003433 metal binding site [ion binding]; metal-binding site 707235003434 dimer interface [polypeptide binding]; other site 707235003435 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235003436 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235003437 active site 707235003438 ATP binding site [chemical binding]; other site 707235003439 substrate binding site [chemical binding]; other site 707235003440 activation loop (A-loop); other site 707235003441 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235003442 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 707235003443 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 707235003444 DNA binding site [nucleotide binding] 707235003445 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235003446 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235003447 phosphopeptide binding site; other site 707235003448 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 707235003449 putative active site [active] 707235003450 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 707235003451 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 707235003452 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235003453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 707235003454 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 707235003455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 707235003456 Walker A/P-loop; other site 707235003457 ATP binding site [chemical binding]; other site 707235003458 Q-loop/lid; other site 707235003459 ABC transporter signature motif; other site 707235003460 Walker B; other site 707235003461 D-loop; other site 707235003462 H-loop/switch region; other site 707235003463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 707235003464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 707235003465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235003466 Walker A/P-loop; other site 707235003467 ATP binding site [chemical binding]; other site 707235003468 Q-loop/lid; other site 707235003469 ABC transporter signature motif; other site 707235003470 Walker B; other site 707235003471 D-loop; other site 707235003472 H-loop/switch region; other site 707235003473 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 707235003474 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 707235003475 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235003476 catalytic core [active] 707235003477 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 707235003478 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 707235003479 active site 707235003480 metal binding site [ion binding]; metal-binding site 707235003481 DNA binding site [nucleotide binding] 707235003482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235003483 Walker A/P-loop; other site 707235003484 ATP binding site [chemical binding]; other site 707235003485 choline dehydrogenase; Validated; Region: PRK02106 707235003486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235003487 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 707235003488 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 707235003489 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 707235003490 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 707235003491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707235003492 Walker A/P-loop; other site 707235003493 ATP binding site [chemical binding]; other site 707235003494 Q-loop/lid; other site 707235003495 ABC transporter signature motif; other site 707235003496 Walker B; other site 707235003497 D-loop; other site 707235003498 H-loop/switch region; other site 707235003499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 707235003500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707235003501 Walker A/P-loop; other site 707235003502 ATP binding site [chemical binding]; other site 707235003503 Q-loop/lid; other site 707235003504 ABC transporter signature motif; other site 707235003505 Walker B; other site 707235003506 D-loop; other site 707235003507 H-loop/switch region; other site 707235003508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 707235003509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 707235003510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235003511 dimer interface [polypeptide binding]; other site 707235003512 conserved gate region; other site 707235003513 putative PBP binding loops; other site 707235003514 ABC-ATPase subunit interface; other site 707235003515 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 707235003516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235003517 dimer interface [polypeptide binding]; other site 707235003518 conserved gate region; other site 707235003519 putative PBP binding loops; other site 707235003520 ABC-ATPase subunit interface; other site 707235003521 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 707235003522 active site clefts [active] 707235003523 zinc binding site [ion binding]; other site 707235003524 dimer interface [polypeptide binding]; other site 707235003525 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 707235003526 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 707235003527 Active Sites [active] 707235003528 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 707235003529 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 707235003530 CysD dimerization site [polypeptide binding]; other site 707235003531 G1 box; other site 707235003532 putative GEF interaction site [polypeptide binding]; other site 707235003533 GTP/Mg2+ binding site [chemical binding]; other site 707235003534 Switch I region; other site 707235003535 G2 box; other site 707235003536 G3 box; other site 707235003537 Switch II region; other site 707235003538 G4 box; other site 707235003539 G5 box; other site 707235003540 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 707235003541 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 707235003542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235003543 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 707235003544 Walker A/P-loop; other site 707235003545 ligand-binding site [chemical binding]; other site 707235003546 ATP binding site [chemical binding]; other site 707235003547 Rrf2 family protein; Region: rrf2_super; TIGR00738 707235003548 Transcriptional regulator; Region: Rrf2; pfam02082 707235003549 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707235003550 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 707235003551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707235003552 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707235003553 Putative esterase; Region: Esterase; pfam00756 707235003554 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 707235003555 Predicted membrane protein [Function unknown]; Region: COG4325 707235003556 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 707235003557 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235003558 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 707235003559 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 707235003560 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 707235003561 active site 707235003562 HIGH motif; other site 707235003563 KMSK motif region; other site 707235003564 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 707235003565 tRNA binding surface [nucleotide binding]; other site 707235003566 anticodon binding site; other site 707235003567 diaminopimelate decarboxylase; Region: lysA; TIGR01048 707235003568 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 707235003569 active site 707235003570 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 707235003571 substrate binding site [chemical binding]; other site 707235003572 catalytic residues [active] 707235003573 dimer interface [polypeptide binding]; other site 707235003574 homoserine dehydrogenase; Provisional; Region: PRK06349 707235003575 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 707235003576 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 707235003577 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 707235003578 threonine synthase; Reviewed; Region: PRK06721 707235003579 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 707235003580 homodimer interface [polypeptide binding]; other site 707235003581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235003582 catalytic residue [active] 707235003583 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 707235003584 transcription termination factor Rho; Provisional; Region: PRK12678 707235003585 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 707235003586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 707235003587 RNA binding site [nucleotide binding]; other site 707235003588 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 707235003589 multimer interface [polypeptide binding]; other site 707235003590 Walker A motif; other site 707235003591 ATP binding site [chemical binding]; other site 707235003592 Walker B motif; other site 707235003593 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 707235003594 peptide chain release factor 1; Region: prfA; TIGR00019 707235003595 This domain is found in peptide chain release factors; Region: PCRF; smart00937 707235003596 RF-1 domain; Region: RF-1; pfam00472 707235003597 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 707235003598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235003599 S-adenosylmethionine binding site [chemical binding]; other site 707235003600 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 707235003601 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 707235003602 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 707235003603 Mg++ binding site [ion binding]; other site 707235003604 putative catalytic motif [active] 707235003605 substrate binding site [chemical binding]; other site 707235003606 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 707235003607 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 707235003608 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 707235003609 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 707235003610 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 707235003611 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 707235003612 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 707235003613 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 707235003614 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 707235003615 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707235003616 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 707235003617 Walker A motif; other site 707235003618 ATP binding site [chemical binding]; other site 707235003619 Walker B motif; other site 707235003620 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 707235003621 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 707235003622 core domain interface [polypeptide binding]; other site 707235003623 delta subunit interface [polypeptide binding]; other site 707235003624 epsilon subunit interface [polypeptide binding]; other site 707235003625 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 707235003626 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707235003627 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 707235003628 alpha subunit interaction interface [polypeptide binding]; other site 707235003629 Walker A motif; other site 707235003630 ATP binding site [chemical binding]; other site 707235003631 Walker B motif; other site 707235003632 inhibitor binding site; inhibition site 707235003633 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 707235003634 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 707235003635 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 707235003636 gamma subunit interface [polypeptide binding]; other site 707235003637 epsilon subunit interface [polypeptide binding]; other site 707235003638 LBP interface [polypeptide binding]; other site 707235003639 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 707235003640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 707235003641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 707235003642 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 707235003643 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 707235003644 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 707235003645 hinge; other site 707235003646 active site 707235003647 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 707235003648 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 707235003649 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 707235003650 DNA binding site [nucleotide binding] 707235003651 active site 707235003652 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 707235003653 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 707235003654 AlkA N-terminal domain; Region: AlkA_N; pfam06029 707235003655 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 707235003656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707235003657 minor groove reading motif; other site 707235003658 helix-hairpin-helix signature motif; other site 707235003659 substrate binding pocket [chemical binding]; other site 707235003660 active site 707235003661 HAMP domain; Region: HAMP; pfam00672 707235003662 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003663 cyclase homology domain; Region: CHD; cd07302 707235003664 nucleotidyl binding site; other site 707235003665 metal binding site [ion binding]; metal-binding site 707235003666 dimer interface [polypeptide binding]; other site 707235003667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235003668 dimerization interface [polypeptide binding]; other site 707235003669 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003670 cyclase homology domain; Region: CHD; cd07302 707235003671 nucleotidyl binding site; other site 707235003672 metal binding site [ion binding]; metal-binding site 707235003673 dimer interface [polypeptide binding]; other site 707235003674 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 707235003675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235003676 dimerization interface [polypeptide binding]; other site 707235003677 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003678 cyclase homology domain; Region: CHD; cd07302 707235003679 nucleotidyl binding site; other site 707235003680 metal binding site [ion binding]; metal-binding site 707235003681 dimer interface [polypeptide binding]; other site 707235003682 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 707235003683 hypothetical protein; Provisional; Region: PRK03298 707235003684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235003685 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 707235003686 dimer interface [polypeptide binding]; other site 707235003687 substrate binding site [chemical binding]; other site 707235003688 metal binding site [ion binding]; metal-binding site 707235003689 putative acyltransferase; Provisional; Region: PRK05790 707235003690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235003691 dimer interface [polypeptide binding]; other site 707235003692 active site 707235003693 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 707235003694 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 707235003695 PE family; Region: PE; pfam00934 707235003696 glycogen branching enzyme; Provisional; Region: PRK05402 707235003697 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 707235003698 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 707235003699 active site 707235003700 catalytic site [active] 707235003701 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 707235003702 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 707235003703 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 707235003704 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 707235003705 active site 707235003706 homodimer interface [polypeptide binding]; other site 707235003707 catalytic site [active] 707235003708 acceptor binding site [chemical binding]; other site 707235003709 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 707235003710 putative homodimer interface [polypeptide binding]; other site 707235003711 putative active site pocket [active] 707235003712 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 707235003713 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 707235003714 DEAD/DEAH box helicase; Region: DEAD; pfam00270 707235003715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 707235003716 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 707235003717 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 707235003718 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 707235003719 active site 707235003720 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 707235003721 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 707235003722 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 707235003723 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 707235003724 putative active site pocket [active] 707235003725 cleavage site 707235003726 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 707235003727 MPN+ (JAMM) motif; other site 707235003728 Zinc-binding site [ion binding]; other site 707235003729 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 707235003730 MoaE interaction surface [polypeptide binding]; other site 707235003731 MoeB interaction surface [polypeptide binding]; other site 707235003732 thiocarboxylated glycine; other site 707235003733 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 707235003734 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 707235003735 dimer interface [polypeptide binding]; other site 707235003736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235003737 catalytic residue [active] 707235003738 Rhomboid family; Region: Rhomboid; pfam01694 707235003739 glutamate racemase; Provisional; Region: PRK00865 707235003740 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 707235003741 ribonuclease PH; Reviewed; Region: rph; PRK00173 707235003742 Ribonuclease PH; Region: RNase_PH_bact; cd11362 707235003743 hexamer interface [polypeptide binding]; other site 707235003744 active site 707235003745 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 707235003746 active site 707235003747 dimerization interface [polypeptide binding]; other site 707235003748 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 707235003749 Glucitol operon activator [Transcription]; Region: GutM; COG4578 707235003750 acyl carrier protein; Validated; Region: PRK05883 707235003751 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 707235003752 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235003753 acyl-activating enzyme (AAE) consensus motif; other site 707235003754 active site 707235003755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235003756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235003757 active site 707235003758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 707235003759 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 707235003760 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 707235003761 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 707235003762 FAD binding pocket [chemical binding]; other site 707235003763 FAD binding motif [chemical binding]; other site 707235003764 phosphate binding motif [ion binding]; other site 707235003765 NAD binding pocket [chemical binding]; other site 707235003766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235003767 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 707235003768 Walker A/P-loop; other site 707235003769 ATP binding site [chemical binding]; other site 707235003770 Q-loop/lid; other site 707235003771 ABC transporter signature motif; other site 707235003772 Walker B; other site 707235003773 D-loop; other site 707235003774 H-loop/switch region; other site 707235003775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235003776 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707235003777 Walker A/P-loop; other site 707235003778 ATP binding site [chemical binding]; other site 707235003779 Q-loop/lid; other site 707235003780 ABC transporter signature motif; other site 707235003781 Walker B; other site 707235003782 D-loop; other site 707235003783 H-loop/switch region; other site 707235003784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 707235003785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235003786 NAD(P) binding site [chemical binding]; other site 707235003787 active site 707235003788 tetracycline repressor protein TetR; Provisional; Region: PRK13756 707235003789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235003790 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 707235003791 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 707235003792 GAF domain; Region: GAF; pfam01590 707235003793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 707235003794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 707235003795 metal binding site [ion binding]; metal-binding site 707235003796 active site 707235003797 I-site; other site 707235003798 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 707235003799 hypothetical protein; Provisional; Region: PRK07877 707235003800 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 707235003801 ATP binding site [chemical binding]; other site 707235003802 substrate interface [chemical binding]; other site 707235003803 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 707235003804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 707235003805 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003806 cyclase homology domain; Region: CHD; cd07302 707235003807 nucleotidyl binding site; other site 707235003808 dimer interface [polypeptide binding]; other site 707235003809 metal binding site [ion binding]; metal-binding site 707235003810 Predicted ATPase [General function prediction only]; Region: COG3903 707235003811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235003812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235003813 DNA binding residues [nucleotide binding] 707235003814 dimerization interface [polypeptide binding]; other site 707235003815 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235003816 cyclase homology domain; Region: CHD; cd07302 707235003817 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 707235003818 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235003819 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235003820 PPE family; Region: PPE; pfam00823 707235003821 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235003822 PAS fold; Region: PAS_4; pfam08448 707235003823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 707235003824 putative active site [active] 707235003825 heme pocket [chemical binding]; other site 707235003826 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 707235003827 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 707235003828 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 707235003829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 707235003830 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235003831 anti sigma factor interaction site; other site 707235003832 regulatory phosphorylation site [posttranslational modification]; other site 707235003833 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235003834 anti sigma factor interaction site; other site 707235003835 regulatory phosphorylation site [posttranslational modification]; other site 707235003836 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 707235003837 synthetase active site [active] 707235003838 NTP binding site [chemical binding]; other site 707235003839 metal binding site [ion binding]; metal-binding site 707235003840 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235003841 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235003842 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 707235003843 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 707235003844 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 707235003845 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 707235003846 putative di-iron ligands [ion binding]; other site 707235003847 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 707235003848 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 707235003849 malonyl-CoA binding site [chemical binding]; other site 707235003850 dimer interface [polypeptide binding]; other site 707235003851 active site 707235003852 product binding site; other site 707235003853 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 707235003854 uncharacterized domain; Region: TIGR00702 707235003855 YcaO-like family; Region: YcaO; pfam02624 707235003856 Uncharacterized conserved protein [Function unknown]; Region: COG3482 707235003857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235003858 S-adenosylmethionine binding site [chemical binding]; other site 707235003859 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235003860 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235003861 active site 707235003862 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 707235003863 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 707235003864 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 707235003865 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 707235003866 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 707235003867 dihydroorotase; Validated; Region: pyrC; PRK09357 707235003868 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 707235003869 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 707235003870 active site 707235003871 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 707235003872 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 707235003873 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 707235003874 catalytic site [active] 707235003875 subunit interface [polypeptide binding]; other site 707235003876 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 707235003877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235003878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235003879 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 707235003880 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235003881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235003882 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 707235003883 IMP binding site; other site 707235003884 dimer interface [polypeptide binding]; other site 707235003885 interdomain contacts; other site 707235003886 partial ornithine binding site; other site 707235003887 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 707235003888 active site 707235003889 dimer interface [polypeptide binding]; other site 707235003890 PE family; Region: PE; pfam00934 707235003891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235003892 PPE family; Region: PPE; pfam00823 707235003893 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 707235003894 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 707235003895 catalytic site [active] 707235003896 G-X2-G-X-G-K; other site 707235003897 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 707235003898 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 707235003899 Flavoprotein; Region: Flavoprotein; pfam02441 707235003900 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 707235003901 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 707235003902 S-adenosylmethionine synthetase; Validated; Region: PRK05250 707235003903 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 707235003904 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 707235003905 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235003906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235003907 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235003908 Cytochrome P450; Region: p450; cl12078 707235003909 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 707235003910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 707235003911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 707235003912 PE family; Region: PE; pfam00934 707235003913 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 707235003914 oligomeric interface; other site 707235003915 putative active site [active] 707235003916 homodimer interface [polypeptide binding]; other site 707235003917 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235003918 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235003919 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235003920 substrate binding pocket [chemical binding]; other site 707235003921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235003922 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235003923 substrate binding pocket [chemical binding]; other site 707235003924 Predicted membrane protein [Function unknown]; Region: COG3714 707235003925 primosome assembly protein PriA; Provisional; Region: PRK14873 707235003926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235003927 S-adenosylmethionine binding site [chemical binding]; other site 707235003928 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235003929 MarR family; Region: MarR; pfam01047 707235003930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235003931 S-adenosylmethionine binding site [chemical binding]; other site 707235003932 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 707235003933 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 707235003934 putative active site [active] 707235003935 substrate binding site [chemical binding]; other site 707235003936 putative cosubstrate binding site; other site 707235003937 catalytic site [active] 707235003938 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 707235003939 substrate binding site [chemical binding]; other site 707235003940 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 707235003941 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 707235003942 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 707235003943 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 707235003944 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 707235003945 substrate binding site [chemical binding]; other site 707235003946 hexamer interface [polypeptide binding]; other site 707235003947 metal binding site [ion binding]; metal-binding site 707235003948 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 707235003949 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 707235003950 catalytic motif [active] 707235003951 Zn binding site [ion binding]; other site 707235003952 RibD C-terminal domain; Region: RibD_C; pfam01872 707235003953 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235003954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235003955 putative substrate translocation pore; other site 707235003956 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 707235003957 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 707235003958 Lumazine binding domain; Region: Lum_binding; pfam00677 707235003959 Lumazine binding domain; Region: Lum_binding; pfam00677 707235003960 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 707235003961 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 707235003962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 707235003963 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 707235003964 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 707235003965 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 707235003966 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 707235003967 dimerization interface [polypeptide binding]; other site 707235003968 active site 707235003969 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 707235003970 homopentamer interface [polypeptide binding]; other site 707235003971 active site 707235003972 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 707235003973 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235003974 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 707235003975 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 707235003976 putative sugar binding sites [chemical binding]; other site 707235003977 Q-X-W motif; other site 707235003978 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 707235003979 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 707235003980 GIY-YIG motif/motif A; other site 707235003981 active site 707235003982 catalytic site [active] 707235003983 putative DNA binding site [nucleotide binding]; other site 707235003984 metal binding site [ion binding]; metal-binding site 707235003985 UvrB/uvrC motif; Region: UVR; pfam02151 707235003986 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 707235003987 Helix-hairpin-helix motif; Region: HHH; pfam00633 707235003988 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 707235003989 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 707235003990 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 707235003991 phosphate binding site [ion binding]; other site 707235003992 putative substrate binding pocket [chemical binding]; other site 707235003993 dimer interface [polypeptide binding]; other site 707235003994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 707235003995 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 707235003996 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235003997 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235003998 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235003999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235004000 acyl-CoA synthetase; Provisional; Region: PRK13382 707235004001 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 707235004002 acyl-activating enzyme (AAE) consensus motif; other site 707235004003 putative AMP binding site [chemical binding]; other site 707235004004 putative active site [active] 707235004005 putative CoA binding site [chemical binding]; other site 707235004006 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235004007 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 707235004008 putative acyl-acceptor binding pocket; other site 707235004009 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235004010 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 707235004011 PE family; Region: PE; pfam00934 707235004012 PE-PPE domain; Region: PE-PPE; pfam08237 707235004013 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 707235004014 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 707235004015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235004016 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 707235004017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 707235004018 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 707235004019 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 707235004020 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 707235004021 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 707235004022 Phosphoglycerate kinase; Region: PGK; pfam00162 707235004023 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 707235004024 substrate binding site [chemical binding]; other site 707235004025 hinge regions; other site 707235004026 ADP binding site [chemical binding]; other site 707235004027 catalytic site [active] 707235004028 triosephosphate isomerase; Provisional; Region: PRK14567 707235004029 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 707235004030 substrate binding site [chemical binding]; other site 707235004031 dimer interface [polypeptide binding]; other site 707235004032 catalytic triad [active] 707235004033 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235004034 Preprotein translocase SecG subunit; Region: SecG; cl09123 707235004035 PE family; Region: PE; pfam00934 707235004036 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 707235004037 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 707235004038 molybdopterin cofactor binding site [chemical binding]; other site 707235004039 substrate binding site [chemical binding]; other site 707235004040 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 707235004041 molybdopterin cofactor binding site; other site 707235004042 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 707235004043 hydrophobic ligand binding site; other site 707235004044 Proteins of 100 residues with WXG; Region: WXG100; cl02005 707235004045 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 707235004046 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 707235004047 putative active site [active] 707235004048 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 707235004049 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 707235004050 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 707235004051 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 707235004052 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 707235004053 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 707235004054 putative active site [active] 707235004055 transaldolase; Provisional; Region: PRK03903 707235004056 catalytic residue [active] 707235004057 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 707235004058 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 707235004059 TPP-binding site [chemical binding]; other site 707235004060 dimer interface [polypeptide binding]; other site 707235004061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 707235004062 PYR/PP interface [polypeptide binding]; other site 707235004063 dimer interface [polypeptide binding]; other site 707235004064 TPP binding site [chemical binding]; other site 707235004065 PE family; Region: PE; pfam00934 707235004066 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 707235004067 UbiA prenyltransferase family; Region: UbiA; pfam01040 707235004068 PE family; Region: PE; pfam00934 707235004069 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235004070 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 707235004071 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 707235004072 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 707235004073 NADP binding site [chemical binding]; other site 707235004074 dimer interface [polypeptide binding]; other site 707235004075 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 707235004076 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 707235004077 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 707235004078 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 707235004079 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 707235004080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 707235004081 Walker A/P-loop; other site 707235004082 ATP binding site [chemical binding]; other site 707235004083 Q-loop/lid; other site 707235004084 ABC transporter signature motif; other site 707235004085 Walker B; other site 707235004086 D-loop; other site 707235004087 H-loop/switch region; other site 707235004088 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 707235004089 Predicted transcriptional regulator [Transcription]; Region: COG2345 707235004090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235004091 putative DNA binding site [nucleotide binding]; other site 707235004092 putative Zn2+ binding site [ion binding]; other site 707235004093 Transcriptional regulator PadR-like family; Region: PadR; cl17335 707235004094 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 707235004095 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 707235004096 protein-splicing catalytic site; other site 707235004097 thioester formation/cholesterol transfer; other site 707235004098 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 707235004099 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 707235004100 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 707235004101 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 707235004102 FeS assembly protein SufD; Region: sufD; TIGR01981 707235004103 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 707235004104 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 707235004105 Walker A/P-loop; other site 707235004106 ATP binding site [chemical binding]; other site 707235004107 Q-loop/lid; other site 707235004108 ABC transporter signature motif; other site 707235004109 Walker B; other site 707235004110 D-loop; other site 707235004111 H-loop/switch region; other site 707235004112 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 707235004113 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 707235004114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235004115 catalytic residue [active] 707235004116 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 707235004117 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 707235004118 trimerization site [polypeptide binding]; other site 707235004119 active site 707235004120 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 707235004121 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 707235004122 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 707235004123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235004124 active site 707235004125 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 707235004126 PE family; Region: PE; pfam00934 707235004127 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 707235004128 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235004129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 707235004130 catalytic residues [active] 707235004131 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 707235004132 catalytic residues [active] 707235004133 enoyl-CoA hydratase; Provisional; Region: PRK05864 707235004134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235004135 substrate binding site [chemical binding]; other site 707235004136 oxyanion hole (OAH) forming residues; other site 707235004137 trimer interface [polypeptide binding]; other site 707235004138 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 707235004139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235004140 Walker A/P-loop; other site 707235004141 ATP binding site [chemical binding]; other site 707235004142 Q-loop/lid; other site 707235004143 ABC transporter signature motif; other site 707235004144 Walker B; other site 707235004145 D-loop; other site 707235004146 H-loop/switch region; other site 707235004147 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235004148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235004149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235004150 aconitate hydratase; Validated; Region: PRK09277 707235004151 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 707235004152 substrate binding site [chemical binding]; other site 707235004153 ligand binding site [chemical binding]; other site 707235004154 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 707235004155 substrate binding site [chemical binding]; other site 707235004156 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707235004157 NlpC/P60 family; Region: NLPC_P60; pfam00877 707235004158 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707235004159 NlpC/P60 family; Region: NLPC_P60; pfam00877 707235004160 MoxR-like ATPases [General function prediction only]; Region: COG0714 707235004161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235004162 Walker A motif; other site 707235004163 ATP binding site [chemical binding]; other site 707235004164 Walker B motif; other site 707235004165 arginine finger; other site 707235004166 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 707235004167 Protein of unknown function DUF58; Region: DUF58; pfam01882 707235004168 hypothetical protein; Provisional; Region: PRK13685 707235004169 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 707235004170 metal ion-dependent adhesion site (MIDAS); other site 707235004171 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235004172 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 707235004173 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 707235004174 NAD(P) binding site [chemical binding]; other site 707235004175 homotetramer interface [polypeptide binding]; other site 707235004176 homodimer interface [polypeptide binding]; other site 707235004177 active site 707235004178 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 707235004179 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 707235004180 NAD binding site [chemical binding]; other site 707235004181 homotetramer interface [polypeptide binding]; other site 707235004182 homodimer interface [polypeptide binding]; other site 707235004183 substrate binding site [chemical binding]; other site 707235004184 active site 707235004185 ferrochelatase; Reviewed; Region: hemH; PRK00035 707235004186 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 707235004187 C-terminal domain interface [polypeptide binding]; other site 707235004188 active site 707235004189 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 707235004190 active site 707235004191 N-terminal domain interface [polypeptide binding]; other site 707235004192 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 707235004193 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 707235004194 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 707235004195 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 707235004196 Uncharacterized conserved protein [Function unknown]; Region: COG0398 707235004197 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 707235004198 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 707235004199 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 707235004200 heterodimer interface [polypeptide binding]; other site 707235004201 substrate interaction site [chemical binding]; other site 707235004202 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 707235004203 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 707235004204 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 707235004205 active site 707235004206 substrate binding site [chemical binding]; other site 707235004207 coenzyme B12 binding site [chemical binding]; other site 707235004208 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 707235004209 B12 binding site [chemical binding]; other site 707235004210 cobalt ligand [ion binding]; other site 707235004211 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235004212 membrane ATPase/protein kinase; Provisional; Region: PRK09435 707235004213 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 707235004214 Walker A; other site 707235004215 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235004216 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235004217 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235004218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004219 S-adenosylmethionine binding site [chemical binding]; other site 707235004220 Uncharacterized conserved protein [Function unknown]; Region: COG3360 707235004221 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 707235004222 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 707235004223 Ligand binding site; other site 707235004224 Putative Catalytic site; other site 707235004225 DXD motif; other site 707235004226 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 707235004227 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 707235004228 active site 707235004229 potential frameshift: common BLAST hit: gi|378771270|ref|YP_005171003.1| TDP-4-oxo-6-deoxy-D-glucose transaminase 707235004230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235004231 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 707235004232 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 707235004233 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 707235004234 inhibitor-cofactor binding pocket; inhibition site 707235004235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004236 catalytic residue [active] 707235004237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235004238 Transposase; Region: HTH_Tnp_1; cl17663 707235004239 putative transposase OrfB; Reviewed; Region: PHA02517 707235004240 HTH-like domain; Region: HTH_21; pfam13276 707235004241 Integrase core domain; Region: rve; pfam00665 707235004242 Integrase core domain; Region: rve_3; pfam13683 707235004243 Methyltransferase domain; Region: Methyltransf_12; pfam08242 707235004244 S-adenosylmethionine binding site [chemical binding]; other site 707235004245 WbqC-like protein family; Region: WbqC; pfam08889 707235004246 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 707235004247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004249 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235004250 Methyltransferase domain; Region: Methyltransf_12; pfam08242 707235004251 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 707235004252 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 707235004253 NADP-binding site; other site 707235004254 homotetramer interface [polypeptide binding]; other site 707235004255 substrate binding site [chemical binding]; other site 707235004256 homodimer interface [polypeptide binding]; other site 707235004257 active site 707235004258 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 707235004259 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 707235004260 NADP binding site [chemical binding]; other site 707235004261 active site 707235004262 putative substrate binding site [chemical binding]; other site 707235004263 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 707235004264 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 707235004265 metal-binding site 707235004266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004267 S-adenosylmethionine binding site [chemical binding]; other site 707235004268 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 707235004269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707235004270 active site 707235004271 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 707235004272 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 707235004273 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 707235004274 active site 707235004275 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 707235004276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235004277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707235004278 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 707235004279 active site 707235004280 acyl-CoA synthetase; Validated; Region: PRK05850 707235004281 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235004282 acyl-activating enzyme (AAE) consensus motif; other site 707235004283 active site 707235004284 Transport protein; Region: actII; TIGR00833 707235004285 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004287 S-adenosylmethionine binding site [chemical binding]; other site 707235004288 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 707235004289 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 707235004290 homodimer interface [polypeptide binding]; other site 707235004291 active site 707235004292 TDP-binding site; other site 707235004293 acceptor substrate-binding pocket; other site 707235004294 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 707235004295 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 707235004296 Probable Catalytic site; other site 707235004297 metal-binding site 707235004298 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 707235004299 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 707235004300 homodimer interface [polypeptide binding]; other site 707235004301 active site 707235004302 TDP-binding site; other site 707235004303 acceptor substrate-binding pocket; other site 707235004304 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235004305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235004306 active site 707235004307 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 707235004308 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235004309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004310 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235004311 Enoylreductase; Region: PKS_ER; smart00829 707235004312 NAD(P) binding site [chemical binding]; other site 707235004313 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235004314 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235004315 putative NADP binding site [chemical binding]; other site 707235004316 active site 707235004317 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235004318 acyl-CoA synthetase; Validated; Region: PRK05850 707235004319 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235004320 acyl-activating enzyme (AAE) consensus motif; other site 707235004321 active site 707235004322 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 707235004323 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 707235004324 NAD(P) binding site [chemical binding]; other site 707235004325 Uncharacterized conserved protein [Function unknown]; Region: COG2128 707235004326 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 707235004327 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 707235004328 CoenzymeA binding site [chemical binding]; other site 707235004329 subunit interaction site [polypeptide binding]; other site 707235004330 PHB binding site; other site 707235004331 Nitronate monooxygenase; Region: NMO; pfam03060 707235004332 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 707235004333 FMN binding site [chemical binding]; other site 707235004334 substrate binding site [chemical binding]; other site 707235004335 putative catalytic residue [active] 707235004336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235004337 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 707235004338 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 707235004339 HIGH motif; other site 707235004340 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 707235004341 active site 707235004342 KMSKS motif; other site 707235004343 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 707235004344 tRNA binding surface [nucleotide binding]; other site 707235004345 anticodon binding site; other site 707235004346 DNA polymerase IV; Provisional; Region: PRK03348 707235004347 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 707235004348 active site 707235004349 DNA binding site [nucleotide binding] 707235004350 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 707235004351 active site 707235004352 homodimer interface [polypeptide binding]; other site 707235004353 homotetramer interface [polypeptide binding]; other site 707235004354 lipoprotein signal peptidase; Provisional; Region: PRK14764 707235004355 lipoprotein signal peptidase; Provisional; Region: PRK14787 707235004356 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 707235004357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 707235004358 active site 707235004359 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 707235004360 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 707235004361 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 707235004362 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 707235004363 apolar tunnel; other site 707235004364 heme binding site [chemical binding]; other site 707235004365 dimerization interface [polypeptide binding]; other site 707235004366 short chain dehydrogenase; Provisional; Region: PRK05866 707235004367 classical (c) SDRs; Region: SDR_c; cd05233 707235004368 NAD(P) binding site [chemical binding]; other site 707235004369 active site 707235004370 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 707235004371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004372 NAD(P) binding site [chemical binding]; other site 707235004373 active site 707235004374 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 707235004375 hydrophobic ligand binding site; other site 707235004376 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 707235004377 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 707235004378 active site 707235004379 PHP Thumb interface [polypeptide binding]; other site 707235004380 metal binding site [ion binding]; metal-binding site 707235004381 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 707235004382 generic binding surface II; other site 707235004383 generic binding surface I; other site 707235004384 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235004385 PPE family; Region: PPE; pfam00823 707235004386 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235004387 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235004388 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 707235004389 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 707235004390 acyl-activating enzyme (AAE) consensus motif; other site 707235004391 putative AMP binding site [chemical binding]; other site 707235004392 putative active site [active] 707235004393 putative CoA binding site [chemical binding]; other site 707235004394 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 707235004395 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 707235004396 putative acyl-acceptor binding pocket; other site 707235004397 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 707235004398 L-aspartate oxidase; Provisional; Region: PRK06175 707235004399 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 707235004400 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 707235004401 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 707235004402 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 707235004403 D-subunit interface [polypeptide binding]; other site 707235004404 Iron-sulfur protein interface; other site 707235004405 proximal quinone binding site [chemical binding]; other site 707235004406 distal quinone binding site [chemical binding]; other site 707235004407 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 707235004408 Iron-sulfur protein interface; other site 707235004409 proximal quinone binding site [chemical binding]; other site 707235004410 C-subunit interface; other site 707235004411 distal quinone binding site; other site 707235004412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235004413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235004414 MMPL family; Region: MMPL; pfam03176 707235004415 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235004416 threonine dehydratase; Validated; Region: PRK08639 707235004417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 707235004418 tetramer interface [polypeptide binding]; other site 707235004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004420 catalytic residue [active] 707235004421 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 707235004422 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235004423 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235004424 putative active site [active] 707235004425 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 707235004426 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 707235004427 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 707235004428 catalytic site [active] 707235004429 active site 707235004430 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 707235004431 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 707235004432 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 707235004433 active site 707235004434 catalytic site [active] 707235004435 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 707235004436 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 707235004437 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 707235004438 active site 707235004439 catalytic site [active] 707235004440 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 707235004441 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707235004442 NlpC/P60 family; Region: NLPC_P60; pfam00877 707235004443 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 707235004444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707235004445 inhibitor-cofactor binding pocket; inhibition site 707235004446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004447 catalytic residue [active] 707235004448 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 707235004449 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 707235004450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235004451 catalytic residue [active] 707235004452 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 707235004453 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 707235004454 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235004455 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235004456 active site 707235004457 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235004458 biotin synthase; Validated; Region: PRK06256 707235004459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235004460 FeS/SAM binding site; other site 707235004461 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 707235004462 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 707235004463 Secretory lipase; Region: LIP; pfam03583 707235004464 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 707235004465 nudix motif; other site 707235004466 quinolinate synthetase; Provisional; Region: PRK09375 707235004467 L-aspartate oxidase; Provisional; Region: PRK07804 707235004468 L-aspartate oxidase; Provisional; Region: PRK06175 707235004469 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 707235004470 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 707235004471 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 707235004472 dimerization interface [polypeptide binding]; other site 707235004473 active site 707235004474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004475 S-adenosylmethionine binding site [chemical binding]; other site 707235004476 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 707235004477 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 707235004478 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 707235004479 NAD binding site [chemical binding]; other site 707235004480 dimerization interface [polypeptide binding]; other site 707235004481 product binding site; other site 707235004482 substrate binding site [chemical binding]; other site 707235004483 zinc binding site [ion binding]; other site 707235004484 catalytic residues [active] 707235004485 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 707235004486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235004487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004488 homodimer interface [polypeptide binding]; other site 707235004489 catalytic residue [active] 707235004490 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 707235004491 4-fold oligomerization interface [polypeptide binding]; other site 707235004492 putative active site pocket [active] 707235004493 metal binding residues [ion binding]; metal-binding site 707235004494 3-fold/trimer interface [polypeptide binding]; other site 707235004495 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 707235004496 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 707235004497 putative active site [active] 707235004498 oxyanion strand; other site 707235004499 catalytic triad [active] 707235004500 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 707235004501 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 707235004502 catalytic residues [active] 707235004503 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 707235004504 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 707235004505 active site 707235004506 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 707235004507 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 707235004508 substrate binding site [chemical binding]; other site 707235004509 glutamase interaction surface [polypeptide binding]; other site 707235004510 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 707235004511 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 707235004512 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 707235004513 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 707235004514 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 707235004515 catalytic triad [active] 707235004516 anthranilate synthase component I; Provisional; Region: PRK13571 707235004517 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 707235004518 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 707235004519 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 707235004520 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 707235004521 active site 707235004522 ribulose/triose binding site [chemical binding]; other site 707235004523 phosphate binding site [ion binding]; other site 707235004524 substrate (anthranilate) binding pocket [chemical binding]; other site 707235004525 product (indole) binding pocket [chemical binding]; other site 707235004526 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 707235004527 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 707235004528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004529 catalytic residue [active] 707235004530 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 707235004531 substrate binding site [chemical binding]; other site 707235004532 active site 707235004533 catalytic residues [active] 707235004534 heterodimer interface [polypeptide binding]; other site 707235004535 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 707235004536 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 707235004537 TM2 domain; Region: TM2; pfam05154 707235004538 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 707235004539 pyruvate kinase; Provisional; Region: PRK06247 707235004540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 707235004541 domain interfaces; other site 707235004542 active site 707235004543 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 707235004544 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 707235004545 active site 707235004546 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 707235004547 catalytic triad [active] 707235004548 dimer interface [polypeptide binding]; other site 707235004549 Uncharacterized conserved protein [Function unknown]; Region: COG2898 707235004550 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 707235004551 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 707235004552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235004553 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 707235004554 Walker A/P-loop; other site 707235004555 Walker A/P-loop; other site 707235004556 ATP binding site [chemical binding]; other site 707235004557 ATP binding site [chemical binding]; other site 707235004558 Q-loop/lid; other site 707235004559 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 707235004560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235004561 Walker A/P-loop; other site 707235004562 ATP binding site [chemical binding]; other site 707235004563 Q-loop/lid; other site 707235004564 ABC transporter signature motif; other site 707235004565 Walker B; other site 707235004566 D-loop; other site 707235004567 H-loop/switch region; other site 707235004568 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 707235004569 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 707235004570 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 707235004571 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 707235004572 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 707235004573 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 707235004574 cyclase homology domain; Region: CHD; cd07302 707235004575 nucleotidyl binding site; other site 707235004576 metal binding site [ion binding]; metal-binding site 707235004577 dimer interface [polypeptide binding]; other site 707235004578 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 707235004579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235004580 active site 707235004581 phosphorylation site [posttranslational modification] 707235004582 intermolecular recognition site; other site 707235004583 dimerization interface [polypeptide binding]; other site 707235004584 ANTAR domain; Region: ANTAR; pfam03861 707235004585 lipid-transfer protein; Provisional; Region: PRK06059 707235004586 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235004587 active site 707235004588 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 707235004589 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 707235004590 DUF35 OB-fold domain; Region: DUF35; pfam01796 707235004591 DNA polymerase I; Provisional; Region: PRK05755 707235004592 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 707235004593 active site 707235004594 metal binding site 1 [ion binding]; metal-binding site 707235004595 putative 5' ssDNA interaction site; other site 707235004596 metal binding site 3; metal-binding site 707235004597 metal binding site 2 [ion binding]; metal-binding site 707235004598 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 707235004599 putative DNA binding site [nucleotide binding]; other site 707235004600 putative metal binding site [ion binding]; other site 707235004601 3'-5' exonuclease; Region: 35EXOc; smart00474 707235004602 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 707235004603 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 707235004604 active site 707235004605 DNA binding site [nucleotide binding] 707235004606 catalytic site [active] 707235004607 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 707235004608 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 707235004609 RNA binding site [nucleotide binding]; other site 707235004610 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 707235004611 RNA binding site [nucleotide binding]; other site 707235004612 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 707235004613 RNA binding site [nucleotide binding]; other site 707235004614 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 707235004615 RNA binding site [nucleotide binding]; other site 707235004616 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 707235004617 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 707235004618 CoA-binding site [chemical binding]; other site 707235004619 ATP-binding [chemical binding]; other site 707235004620 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 707235004621 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 707235004622 excinuclease ABC subunit B; Provisional; Region: PRK05298 707235004623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235004624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235004625 nucleotide binding region [chemical binding]; other site 707235004626 ATP-binding site [chemical binding]; other site 707235004627 Ultra-violet resistance protein B; Region: UvrB; pfam12344 707235004628 UvrB/uvrC motif; Region: UVR; pfam02151 707235004629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235004630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235004631 putative substrate translocation pore; other site 707235004632 Predicted membrane protein [Function unknown]; Region: COG5305 707235004633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235004634 Ligand Binding Site [chemical binding]; other site 707235004635 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 707235004636 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 707235004637 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 707235004638 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 707235004639 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 707235004640 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 707235004641 Predicted esterase [General function prediction only]; Region: COG0627 707235004642 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 707235004643 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 707235004644 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 707235004645 dimer interface [polypeptide binding]; other site 707235004646 putative anticodon binding site; other site 707235004647 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707235004648 motif 1; other site 707235004649 dimer interface [polypeptide binding]; other site 707235004650 active site 707235004651 motif 2; other site 707235004652 motif 3; other site 707235004653 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 707235004654 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 707235004655 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 707235004656 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 707235004657 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 707235004658 23S rRNA binding site [nucleotide binding]; other site 707235004659 L21 binding site [polypeptide binding]; other site 707235004660 L13 binding site [polypeptide binding]; other site 707235004661 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 707235004662 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 707235004663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 707235004664 PE family; Region: PE; pfam00934 707235004665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235004666 cyclase homology domain; Region: CHD; cd07302 707235004667 nucleotidyl binding site; other site 707235004668 metal binding site [ion binding]; metal-binding site 707235004669 dimer interface [polypeptide binding]; other site 707235004670 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 707235004671 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 707235004672 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 707235004673 dimer interface [polypeptide binding]; other site 707235004674 motif 1; other site 707235004675 active site 707235004676 motif 2; other site 707235004677 motif 3; other site 707235004678 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 707235004679 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 707235004680 putative tRNA-binding site [nucleotide binding]; other site 707235004681 B3/4 domain; Region: B3_4; pfam03483 707235004682 tRNA synthetase B5 domain; Region: B5; smart00874 707235004683 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 707235004684 dimer interface [polypeptide binding]; other site 707235004685 motif 1; other site 707235004686 motif 3; other site 707235004687 motif 2; other site 707235004688 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 707235004689 PE family; Region: PE; pfam00934 707235004690 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 707235004691 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 707235004692 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 707235004693 heterotetramer interface [polypeptide binding]; other site 707235004694 active site pocket [active] 707235004695 cleavage site 707235004696 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 707235004697 feedback inhibition sensing region; other site 707235004698 homohexameric interface [polypeptide binding]; other site 707235004699 nucleotide binding site [chemical binding]; other site 707235004700 N-acetyl-L-glutamate binding site [chemical binding]; other site 707235004701 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 707235004702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707235004703 inhibitor-cofactor binding pocket; inhibition site 707235004704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235004705 catalytic residue [active] 707235004706 ornithine carbamoyltransferase; Provisional; Region: PRK00779 707235004707 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 707235004708 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 707235004709 arginine repressor; Provisional; Region: PRK03341 707235004710 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 707235004711 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 707235004712 argininosuccinate synthase; Provisional; Region: PRK13820 707235004713 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 707235004714 ANP binding site [chemical binding]; other site 707235004715 Substrate Binding Site II [chemical binding]; other site 707235004716 Substrate Binding Site I [chemical binding]; other site 707235004717 argininosuccinate lyase; Provisional; Region: PRK00855 707235004718 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 707235004719 active sites [active] 707235004720 tetramer interface [polypeptide binding]; other site 707235004721 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 707235004722 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 707235004723 malonyl-CoA binding site [chemical binding]; other site 707235004724 dimer interface [polypeptide binding]; other site 707235004725 active site 707235004726 product binding site; other site 707235004727 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235004728 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235004729 active site 707235004730 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235004731 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235004732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004733 Enoylreductase; Region: PKS_ER; smart00829 707235004734 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235004735 NAD(P) binding site [chemical binding]; other site 707235004736 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 707235004737 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235004738 putative NADP binding site [chemical binding]; other site 707235004739 active site 707235004740 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235004741 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235004742 active site 707235004743 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235004744 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235004745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235004746 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235004747 Enoylreductase; Region: PKS_ER; smart00829 707235004748 NAD(P) binding site [chemical binding]; other site 707235004749 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 707235004750 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 707235004751 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235004752 putative NADP binding site [chemical binding]; other site 707235004753 active site 707235004754 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235004755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235004756 Transposase; Region: HTH_Tnp_1; cl17663 707235004757 putative transposase OrfB; Reviewed; Region: PHA02517 707235004758 HTH-like domain; Region: HTH_21; pfam13276 707235004759 Integrase core domain; Region: rve; pfam00665 707235004760 Integrase core domain; Region: rve_3; pfam13683 707235004761 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 707235004762 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 707235004763 malonyl-CoA binding site [chemical binding]; other site 707235004764 dimer interface [polypeptide binding]; other site 707235004765 active site 707235004766 product binding site; other site 707235004767 Cytochrome P450; Region: p450; cl12078 707235004768 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235004769 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 707235004770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235004771 ABC transporter; Region: ABC_tran_2; pfam12848 707235004772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 707235004774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235004775 putative substrate translocation pore; other site 707235004776 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 707235004777 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 707235004778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235004779 dimerization interface [polypeptide binding]; other site 707235004780 putative DNA binding site [nucleotide binding]; other site 707235004781 putative Zn2+ binding site [ion binding]; other site 707235004782 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 707235004783 active site residue [active] 707235004784 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235004785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235004786 ligand binding site [chemical binding]; other site 707235004787 flexible hinge region; other site 707235004788 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 707235004789 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 707235004790 putative catalytic residues [active] 707235004791 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 707235004792 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235004793 catalytic residues [active] 707235004794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235004795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235004796 active site 707235004797 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 707235004798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 707235004799 substrate binding pocket [chemical binding]; other site 707235004800 membrane-bound complex binding site; other site 707235004801 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 707235004802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235004803 FeS/SAM binding site; other site 707235004804 DivIVA protein; Region: DivIVA; pfam05103 707235004805 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 707235004806 acyl-CoA synthetase; Validated; Region: PRK07868 707235004807 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 707235004808 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235004809 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235004810 acyl-activating enzyme (AAE) consensus motif; other site 707235004811 AMP binding site [chemical binding]; other site 707235004812 active site 707235004813 CoA binding site [chemical binding]; other site 707235004814 Uncharacterized conserved protein [Function unknown]; Region: COG2835 707235004815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235004816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235004817 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 707235004818 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 707235004819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 707235004820 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 707235004821 Walker A/P-loop; other site 707235004822 ATP binding site [chemical binding]; other site 707235004823 Q-loop/lid; other site 707235004824 ABC transporter signature motif; other site 707235004825 Walker B; other site 707235004826 D-loop; other site 707235004827 H-loop/switch region; other site 707235004828 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 707235004829 active site 707235004830 DNA binding site [nucleotide binding] 707235004831 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 707235004832 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 707235004833 active site 707235004834 HIGH motif; other site 707235004835 dimer interface [polypeptide binding]; other site 707235004836 KMSKS motif; other site 707235004837 S4 RNA-binding domain; Region: S4; smart00363 707235004838 RNA binding surface [nucleotide binding]; other site 707235004839 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235004840 Tetratrico peptide repeat; Region: TPR_5; pfam12688 707235004841 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 707235004842 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 707235004843 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 707235004844 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 707235004845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707235004846 RNA binding surface [nucleotide binding]; other site 707235004847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004848 S-adenosylmethionine binding site [chemical binding]; other site 707235004849 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 707235004850 ATP-NAD kinase; Region: NAD_kinase; pfam01513 707235004851 DNA repair protein RecN; Region: recN; TIGR00634 707235004852 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 707235004853 Walker A/P-loop; other site 707235004854 ATP binding site [chemical binding]; other site 707235004855 Q-loop/lid; other site 707235004856 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 707235004857 ABC transporter signature motif; other site 707235004858 Walker B; other site 707235004859 D-loop; other site 707235004860 H-loop/switch region; other site 707235004861 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 707235004862 Thiamine pyrophosphokinase; Region: TPK; cl08415 707235004863 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 707235004864 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 707235004865 CTP synthetase; Validated; Region: pyrG; PRK05380 707235004866 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 707235004867 Catalytic site [active] 707235004868 active site 707235004869 UTP binding site [chemical binding]; other site 707235004870 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 707235004871 active site 707235004872 putative oxyanion hole; other site 707235004873 catalytic triad [active] 707235004874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 707235004875 dimer interface [polypeptide binding]; other site 707235004876 ADP-ribose binding site [chemical binding]; other site 707235004877 active site 707235004878 nudix motif; other site 707235004879 metal binding site [ion binding]; metal-binding site 707235004880 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 707235004881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235004882 active site 707235004883 DNA binding site [nucleotide binding] 707235004884 Int/Topo IB signature motif; other site 707235004885 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235004886 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235004887 active site 707235004888 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 707235004889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235004890 S-adenosylmethionine binding site [chemical binding]; other site 707235004891 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 707235004892 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235004893 PPE family; Region: PPE; pfam00823 707235004894 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235004895 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235004896 PPE family; Region: PPE; pfam00823 707235004897 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235004898 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 707235004899 Sulfate transporter family; Region: Sulfate_transp; pfam00916 707235004900 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 707235004901 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 707235004902 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235004903 P-loop; other site 707235004904 Magnesium ion binding site [ion binding]; other site 707235004905 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235004906 Magnesium ion binding site [ion binding]; other site 707235004907 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 707235004908 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 707235004909 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 707235004910 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707235004911 RNA binding surface [nucleotide binding]; other site 707235004912 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 707235004913 active site 707235004914 cytidylate kinase; Provisional; Region: cmk; PRK00023 707235004915 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 707235004916 CMP-binding site; other site 707235004917 The sites determining sugar specificity; other site 707235004918 GTP-binding protein Der; Reviewed; Region: PRK03003 707235004919 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 707235004920 GTP/Mg2+ binding site [chemical binding]; other site 707235004921 Switch I region; other site 707235004922 G2 box; other site 707235004923 Switch II region; other site 707235004924 G3 box; other site 707235004925 G4 box; other site 707235004926 G5 box; other site 707235004927 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 707235004928 G1 box; other site 707235004929 GTP/Mg2+ binding site [chemical binding]; other site 707235004930 Switch I region; other site 707235004931 G2 box; other site 707235004932 G3 box; other site 707235004933 Switch II region; other site 707235004934 G4 box; other site 707235004935 G5 box; other site 707235004936 short chain dehydrogenase; Provisional; Region: PRK07060 707235004937 classical (c) SDRs; Region: SDR_c; cd05233 707235004938 NAD(P) binding site [chemical binding]; other site 707235004939 active site 707235004940 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 707235004941 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 707235004942 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 707235004943 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 707235004944 Cupin domain; Region: Cupin_2; cl17218 707235004945 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 707235004946 Transcriptional regulator [Transcription]; Region: IclR; COG1414 707235004947 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 707235004948 putative switch regulator; other site 707235004949 non-specific DNA interactions [nucleotide binding]; other site 707235004950 DNA binding site [nucleotide binding] 707235004951 sequence specific DNA binding site [nucleotide binding]; other site 707235004952 putative cAMP binding site [chemical binding]; other site 707235004953 Bacterial transcriptional regulator; Region: IclR; pfam01614 707235004954 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 707235004955 putative active site [active] 707235004956 homotetrameric interface [polypeptide binding]; other site 707235004957 metal binding site [ion binding]; metal-binding site 707235004958 biotin carboxylase-like protein; Validated; Region: PRK06524 707235004959 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235004960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235004961 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235004962 Predicted transcriptional regulators [Transcription]; Region: COG1733 707235004963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235004964 dimerization interface [polypeptide binding]; other site 707235004965 putative DNA binding site [nucleotide binding]; other site 707235004966 putative Zn2+ binding site [ion binding]; other site 707235004967 Predicted transcriptional regulators [Transcription]; Region: COG1733 707235004968 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235004969 FAD binding domain; Region: FAD_binding_4; pfam01565 707235004970 Berberine and berberine like; Region: BBE; pfam08031 707235004971 TIGR03086 family protein; Region: TIGR03086 707235004972 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235004973 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235004974 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235004975 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235004976 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235004977 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 707235004978 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 707235004979 NAD(P) binding site [chemical binding]; other site 707235004980 catalytic residues [active] 707235004981 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 707235004982 putative catalytic residue [active] 707235004983 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 707235004984 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707235004985 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 707235004986 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 707235004987 gating phenylalanine in ion channel; other site 707235004988 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 707235004989 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235004990 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 707235004991 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 707235004992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235004993 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 707235004994 putative substrate translocation pore; other site 707235004995 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 707235004996 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 707235004997 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 707235004998 Sulfate transporter family; Region: Sulfate_transp; pfam00916 707235004999 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 707235005000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 707235005001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 707235005002 putative active site [active] 707235005003 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 707235005004 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235005005 active site 707235005006 ATP binding site [chemical binding]; other site 707235005007 substrate binding site [chemical binding]; other site 707235005008 activation loop (A-loop); other site 707235005009 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 707235005010 Thioredoxin; Region: Thioredoxin_4; cl17273 707235005011 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 707235005012 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 707235005013 active site 707235005014 metal binding site [ion binding]; metal-binding site 707235005015 nudix motif; other site 707235005016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235005017 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235005018 active site 707235005019 ATP binding site [chemical binding]; other site 707235005020 substrate binding site [chemical binding]; other site 707235005021 activation loop (A-loop); other site 707235005022 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235005023 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235005024 phosphopeptide binding site; other site 707235005025 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235005026 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235005027 phosphopeptide binding site; other site 707235005028 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 707235005029 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 707235005030 Walker A/P-loop; other site 707235005031 ATP binding site [chemical binding]; other site 707235005032 Q-loop/lid; other site 707235005033 ABC transporter signature motif; other site 707235005034 Walker B; other site 707235005035 D-loop; other site 707235005036 H-loop/switch region; other site 707235005037 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 707235005038 acyl-CoA synthetase; Provisional; Region: PRK13388 707235005039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235005040 acyl-activating enzyme (AAE) consensus motif; other site 707235005041 AMP binding site [chemical binding]; other site 707235005042 active site 707235005043 CoA binding site [chemical binding]; other site 707235005044 hypothetical protein; Provisional; Region: PRK06185 707235005045 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 707235005046 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 707235005047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 707235005048 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005049 PPE family; Region: PPE; pfam00823 707235005050 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005051 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005052 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 707235005053 putative transposase OrfB; Reviewed; Region: PHA02517 707235005054 HTH-like domain; Region: HTH_21; pfam13276 707235005055 Integrase core domain; Region: rve; pfam00665 707235005056 Integrase core domain; Region: rve_3; pfam13683 707235005057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235005058 Transposase; Region: HTH_Tnp_1; cl17663 707235005059 Cutinase; Region: Cutinase; pfam01083 707235005060 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235005061 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235005062 Uncharacterized conserved protein [Function unknown]; Region: COG0393 707235005063 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 707235005064 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235005065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235005066 active site 707235005067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235005068 Transposase; Region: HTH_Tnp_1; cl17663 707235005069 putative transposase OrfB; Reviewed; Region: PHA02517 707235005070 HTH-like domain; Region: HTH_21; pfam13276 707235005071 Integrase core domain; Region: rve; pfam00665 707235005072 Integrase core domain; Region: rve_3; pfam13683 707235005073 Integrase core domain; Region: rve; pfam00665 707235005074 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 707235005075 putative homotetramer interface [polypeptide binding]; other site 707235005076 putative homodimer interface [polypeptide binding]; other site 707235005077 putative allosteric switch controlling residues; other site 707235005078 putative metal binding site [ion binding]; other site 707235005079 putative homodimer-homodimer interface [polypeptide binding]; other site 707235005080 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 707235005081 PE family; Region: PE; pfam00934 707235005082 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 707235005083 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 707235005084 dimer interface [polypeptide binding]; other site 707235005085 active site 707235005086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 707235005087 substrate binding site [chemical binding]; other site 707235005088 catalytic residue [active] 707235005089 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 707235005090 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 707235005091 metal binding site [ion binding]; metal-binding site 707235005092 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 707235005093 FAD binding domain; Region: FAD_binding_4; pfam01565 707235005094 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 707235005095 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 707235005096 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 707235005097 Transcriptional regulator [Transcription]; Region: IclR; COG1414 707235005098 Bacterial transcriptional regulator; Region: IclR; pfam01614 707235005099 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235005100 FAD binding domain; Region: FAD_binding_4; pfam01565 707235005101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235005102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235005103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235005104 Cytochrome P450; Region: p450; cl12078 707235005105 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 707235005106 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 707235005107 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 707235005108 Protein of unknown function (DUF690); Region: DUF690; pfam05108 707235005109 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 707235005110 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235005111 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 707235005112 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235005113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235005114 Cytochrome P450; Region: p450; cl12078 707235005115 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 707235005116 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005117 PPE family; Region: PPE; pfam00823 707235005118 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235005119 PE family; Region: PE; pfam00934 707235005120 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005121 PPE family; Region: PPE; pfam00823 707235005122 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235005123 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005124 PPE family; Region: PPE; pfam00823 707235005125 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235005126 PE family; Region: PE; pfam00934 707235005127 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235005128 EspG family; Region: ESX-1_EspG; pfam14011 707235005129 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 707235005130 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235005131 catalytic residues [active] 707235005132 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 707235005133 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 707235005134 active site 707235005135 catalytic residues [active] 707235005136 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 707235005137 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 707235005138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235005139 Walker A motif; other site 707235005140 ATP binding site [chemical binding]; other site 707235005141 Walker B motif; other site 707235005142 arginine finger; other site 707235005143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235005144 Transposase; Region: HTH_Tnp_1; cl17663 707235005145 putative transposase OrfB; Reviewed; Region: PHA02517 707235005146 HTH-like domain; Region: HTH_21; pfam13276 707235005147 Integrase core domain; Region: rve; pfam00665 707235005148 Integrase core domain; Region: rve_3; pfam13683 707235005149 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005150 PPE family; Region: PPE; pfam00823 707235005151 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005152 PPE family; Region: PPE; pfam00823 707235005153 PE family; Region: PE; pfam00934 707235005154 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235005155 PE family; Region: PE; pfam00934 707235005156 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005157 PPE family; Region: PPE; pfam00823 707235005158 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005159 PPE family; Region: PPE; pfam00823 707235005160 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005161 PPE family; Region: PPE; pfam00823 707235005162 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235005163 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235005164 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 707235005165 MgtC family; Region: MgtC; pfam02308 707235005166 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 707235005167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235005168 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 707235005169 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 707235005170 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 707235005171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235005172 hypothetical protein; Validated; Region: PRK07121 707235005173 PE family; Region: PE; pfam00934 707235005174 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 707235005175 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 707235005176 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 707235005177 hypothetical protein; Provisional; Region: PRK05858 707235005178 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 707235005179 PYR/PP interface [polypeptide binding]; other site 707235005180 dimer interface [polypeptide binding]; other site 707235005181 TPP binding site [chemical binding]; other site 707235005182 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 707235005183 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 707235005184 TPP-binding site; other site 707235005185 dimer interface [polypeptide binding]; other site 707235005186 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 707235005187 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 707235005188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 707235005189 nucleotide binding region [chemical binding]; other site 707235005190 ATP-binding site [chemical binding]; other site 707235005191 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 707235005192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 707235005193 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 707235005194 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 707235005195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 707235005196 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 707235005197 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 707235005198 lipoyl attachment site [posttranslational modification]; other site 707235005199 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235005200 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235005201 phosphopeptide binding site; other site 707235005202 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 707235005203 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 707235005204 DNA binding residues [nucleotide binding] 707235005205 Bifunctional nuclease; Region: DNase-RNase; pfam02577 707235005206 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 707235005207 DNA binding residues [nucleotide binding] 707235005208 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 707235005209 putative dimer interface [polypeptide binding]; other site 707235005210 glycine dehydrogenase; Provisional; Region: PRK05367 707235005211 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 707235005212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235005213 tetramer interface [polypeptide binding]; other site 707235005214 catalytic residue [active] 707235005215 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 707235005216 tetramer interface [polypeptide binding]; other site 707235005217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235005218 catalytic residue [active] 707235005219 haloalkane dehalogenase; Provisional; Region: PRK03204 707235005220 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235005221 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 707235005222 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 707235005223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 707235005224 metal ion-dependent adhesion site (MIDAS); other site 707235005225 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 707235005226 active site 707235005227 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235005228 putative active site [active] 707235005229 Domain of unknown function DUF21; Region: DUF21; pfam01595 707235005230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707235005231 FOG: CBS domain [General function prediction only]; Region: COG0517 707235005232 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 707235005233 Domain of unknown function DUF21; Region: DUF21; pfam01595 707235005234 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707235005235 Transporter associated domain; Region: CorC_HlyC; smart01091 707235005236 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 707235005237 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235005238 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 707235005239 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 707235005240 active site 707235005241 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 707235005242 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 707235005243 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 707235005244 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 707235005245 Predicted transcriptional regulator [Transcription]; Region: COG3682 707235005246 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 707235005247 CoenzymeA binding site [chemical binding]; other site 707235005248 subunit interaction site [polypeptide binding]; other site 707235005249 PHB binding site; other site 707235005250 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 707235005251 alpha-gamma subunit interface [polypeptide binding]; other site 707235005252 beta-gamma subunit interface [polypeptide binding]; other site 707235005253 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 707235005254 gamma-beta subunit interface [polypeptide binding]; other site 707235005255 alpha-beta subunit interface [polypeptide binding]; other site 707235005256 urease subunit alpha; Reviewed; Region: ureC; PRK13206 707235005257 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 707235005258 subunit interactions [polypeptide binding]; other site 707235005259 active site 707235005260 flap region; other site 707235005261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 707235005262 UreD urease accessory protein; Region: UreD; cl00530 707235005263 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 707235005264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235005265 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 707235005266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235005267 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235005268 classical (c) SDRs; Region: SDR_c; cd05233 707235005269 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 707235005270 NAD(P) binding site [chemical binding]; other site 707235005271 active site 707235005272 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 707235005273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 707235005274 sulfate transport protein; Provisional; Region: cysT; CHL00187 707235005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235005276 dimer interface [polypeptide binding]; other site 707235005277 conserved gate region; other site 707235005278 putative PBP binding loops; other site 707235005279 ABC-ATPase subunit interface; other site 707235005280 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 707235005281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235005282 Walker A/P-loop; other site 707235005283 ATP binding site [chemical binding]; other site 707235005284 Q-loop/lid; other site 707235005285 ABC transporter signature motif; other site 707235005286 Walker B; other site 707235005287 D-loop; other site 707235005288 H-loop/switch region; other site 707235005289 TOBE domain; Region: TOBE; pfam03459 707235005290 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 707235005291 Predicted membrane protein [Function unknown]; Region: COG2261 707235005292 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 707235005293 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 707235005294 putative NAD(P) binding site [chemical binding]; other site 707235005295 putative substrate binding site [chemical binding]; other site 707235005296 catalytic Zn binding site [ion binding]; other site 707235005297 structural Zn binding site [ion binding]; other site 707235005298 CAAX protease self-immunity; Region: Abi; pfam02517 707235005299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 707235005300 MOSC domain; Region: MOSC; pfam03473 707235005301 short chain dehydrogenase; Provisional; Region: PRK07825 707235005302 classical (c) SDRs; Region: SDR_c; cd05233 707235005303 NAD(P) binding site [chemical binding]; other site 707235005304 active site 707235005305 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 707235005306 CoA-transferase family III; Region: CoA_transf_3; pfam02515 707235005307 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 707235005308 CoA-transferase family III; Region: CoA_transf_3; pfam02515 707235005309 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 707235005310 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235005311 active site 707235005312 hypothetical protein; Provisional; Region: PRK12320 707235005313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005314 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 707235005315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235005316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235005317 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235005318 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 707235005319 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 707235005320 active site 707235005321 substrate binding site [chemical binding]; other site 707235005322 FMN binding site [chemical binding]; other site 707235005323 putative catalytic residues [active] 707235005324 Uncharacterized conserved protein [Function unknown]; Region: COG5579 707235005325 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 707235005326 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 707235005327 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 707235005328 heme binding site [chemical binding]; other site 707235005329 ferroxidase pore; other site 707235005330 ferroxidase diiron center [ion binding]; other site 707235005331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235005332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235005333 putative substrate translocation pore; other site 707235005334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235005335 putative substrate translocation pore; other site 707235005336 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 707235005337 23S rRNA interface [nucleotide binding]; other site 707235005338 L3 interface [polypeptide binding]; other site 707235005339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235005340 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 707235005341 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 707235005342 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 707235005343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235005344 Cytochrome P450; Region: p450; cl12078 707235005345 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 707235005346 short chain dehydrogenase; Provisional; Region: PRK08267 707235005347 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 707235005348 putative NAD(P) binding site [chemical binding]; other site 707235005349 active site 707235005350 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 707235005351 hydrophobic ligand binding site; other site 707235005352 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 707235005353 chorismate mutase; Provisional; Region: PRK09269 707235005354 chorismate mutase, putative; Region: CM_mono2; TIGR01806 707235005355 Putative esterase; Region: Esterase; pfam00756 707235005356 Leucine carboxyl methyltransferase; Region: LCM; cl01306 707235005357 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235005358 Leucine carboxyl methyltransferase; Region: LCM; cl01306 707235005359 Uncharacterized conserved protein [Function unknown]; Region: COG2353 707235005360 Nitronate monooxygenase; Region: NMO; pfam03060 707235005361 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 707235005362 FMN binding site [chemical binding]; other site 707235005363 substrate binding site [chemical binding]; other site 707235005364 putative catalytic residue [active] 707235005365 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 707235005366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 707235005367 catalytic Zn binding site [ion binding]; other site 707235005368 NAD(P) binding site [chemical binding]; other site 707235005369 structural Zn binding site [ion binding]; other site 707235005370 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235005371 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235005372 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 707235005373 putative active site [active] 707235005374 dimerization interface [polypeptide binding]; other site 707235005375 putative tRNAtyr binding site [nucleotide binding]; other site 707235005376 Domain of unknown function DUF77; Region: DUF77; pfam01910 707235005377 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 707235005378 putative ADP-ribose binding site [chemical binding]; other site 707235005379 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235005380 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235005381 cyclase homology domain; Region: CHD; cd07302 707235005382 nucleotidyl binding site; other site 707235005383 metal binding site [ion binding]; metal-binding site 707235005384 dimer interface [polypeptide binding]; other site 707235005385 competence damage-inducible protein A; Provisional; Region: PRK00549 707235005386 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 707235005387 putative MPT binding site; other site 707235005388 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 707235005389 putative sialic acid transporter; Region: 2A0112; TIGR00891 707235005390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235005391 putative substrate translocation pore; other site 707235005392 Predicted membrane protein [Function unknown]; Region: COG1950 707235005393 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235005394 anti sigma factor interaction site; other site 707235005395 regulatory phosphorylation site [posttranslational modification]; other site 707235005396 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 707235005397 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 707235005398 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 707235005399 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 707235005400 dimer interface [polypeptide binding]; other site 707235005401 active site 707235005402 heme binding site [chemical binding]; other site 707235005403 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 707235005404 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 707235005405 metal binding site 2 [ion binding]; metal-binding site 707235005406 putative DNA binding helix; other site 707235005407 metal binding site 1 [ion binding]; metal-binding site 707235005408 dimer interface [polypeptide binding]; other site 707235005409 structural Zn2+ binding site [ion binding]; other site 707235005410 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 707235005411 substrate binding site [chemical binding]; other site 707235005412 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 707235005413 substrate binding site [chemical binding]; other site 707235005414 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 707235005415 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 707235005416 putative NAD(P) binding site [chemical binding]; other site 707235005417 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 707235005418 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 707235005419 tetramer interface [polypeptide binding]; other site 707235005420 active site 707235005421 Mg2+/Mn2+ binding site [ion binding]; other site 707235005422 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 707235005423 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005424 PPE family; Region: PPE; pfam00823 707235005425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005426 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005427 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005428 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005429 PPE family; Region: PPE; pfam00823 707235005430 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005431 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235005432 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 707235005433 putative hydrophobic ligand binding site [chemical binding]; other site 707235005434 protein interface [polypeptide binding]; other site 707235005435 gate; other site 707235005436 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235005437 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 707235005438 putative acyl-acceptor binding pocket; other site 707235005439 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 707235005440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235005441 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235005442 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235005443 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235005444 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 707235005445 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235005446 acyl-activating enzyme (AAE) consensus motif; other site 707235005447 active site 707235005448 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 707235005449 Uncharacterized conserved protein [Function unknown]; Region: COG3361 707235005450 short chain dehydrogenase; Provisional; Region: PRK05867 707235005451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005452 NAD(P) binding site [chemical binding]; other site 707235005453 active site 707235005454 TIGR03085 family protein; Region: TIGR03085 707235005455 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 707235005456 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 707235005457 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 707235005458 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 707235005459 conserved cys residue [active] 707235005460 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 707235005461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 707235005462 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 707235005463 dimer interface [polypeptide binding]; other site 707235005464 catalytic triad [active] 707235005465 peroxidatic and resolving cysteines [active] 707235005466 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235005467 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 707235005468 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 707235005469 active site 707235005470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235005471 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 707235005472 FAD binding site [chemical binding]; other site 707235005473 substrate binding site [chemical binding]; other site 707235005474 catalytic base [active] 707235005475 enoyl-CoA hydratase; Provisional; Region: PRK08290 707235005476 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235005477 substrate binding site [chemical binding]; other site 707235005478 oxyanion hole (OAH) forming residues; other site 707235005479 trimer interface [polypeptide binding]; other site 707235005480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235005481 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 707235005482 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 707235005483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235005484 catalytic loop [active] 707235005485 iron binding site [ion binding]; other site 707235005486 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 707235005487 FAD binding pocket [chemical binding]; other site 707235005488 FAD binding motif [chemical binding]; other site 707235005489 phosphate binding motif [ion binding]; other site 707235005490 beta-alpha-beta structure motif; other site 707235005491 NAD binding pocket [chemical binding]; other site 707235005492 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235005493 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235005494 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 707235005495 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 707235005496 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 707235005497 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 707235005498 dimerization interface [polypeptide binding]; other site 707235005499 active site 707235005500 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 707235005501 putative NAD(P) binding site [chemical binding]; other site 707235005502 active site 707235005503 homodimer interface [polypeptide binding]; other site 707235005504 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235005505 SEC-C motif; Region: SEC-C; pfam02810 707235005506 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235005507 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235005508 active site 707235005509 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 707235005510 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 707235005511 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 707235005512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235005513 non-specific DNA binding site [nucleotide binding]; other site 707235005514 salt bridge; other site 707235005515 sequence-specific DNA binding site [nucleotide binding]; other site 707235005516 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 707235005517 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 707235005518 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 707235005519 putative active site [active] 707235005520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235005521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235005522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235005523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235005524 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235005525 Permease; Region: Permease; pfam02405 707235005526 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235005527 Permease; Region: Permease; pfam02405 707235005528 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005529 mce related protein; Region: MCE; pfam02470 707235005530 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235005531 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005532 mce related protein; Region: MCE; pfam02470 707235005533 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005534 mce related protein; Region: MCE; pfam02470 707235005535 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005536 mce related protein; Region: MCE; pfam02470 707235005537 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005538 mce related protein; Region: MCE; pfam02470 707235005539 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235005540 mce related protein; Region: MCE; pfam02470 707235005541 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235005542 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 707235005543 YacP-like NYN domain; Region: NYN_YacP; cl01491 707235005544 Peptidase family M48; Region: Peptidase_M48; pfam01435 707235005545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235005546 S-adenosylmethionine binding site [chemical binding]; other site 707235005547 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 707235005548 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 707235005549 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 707235005550 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 707235005551 dimer interface [polypeptide binding]; other site 707235005552 putative radical transfer pathway; other site 707235005553 diiron center [ion binding]; other site 707235005554 tyrosyl radical; other site 707235005555 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 707235005556 putative active site [active] 707235005557 PE family; Region: PE; pfam00934 707235005558 Cutinase; Region: Cutinase; pfam01083 707235005559 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 707235005560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 707235005561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 707235005562 dimerization interface [polypeptide binding]; other site 707235005563 Lysine efflux permease [General function prediction only]; Region: COG1279 707235005564 Cellulose binding domain; Region: CBM_2; pfam00553 707235005565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235005566 S-adenosylmethionine binding site [chemical binding]; other site 707235005567 Uncharacterized conserved protein [Function unknown]; Region: COG5654 707235005568 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 707235005569 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 707235005570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005571 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235005572 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 707235005573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235005574 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 707235005575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235005576 dimerization interface [polypeptide binding]; other site 707235005577 putative DNA binding site [nucleotide binding]; other site 707235005578 putative Zn2+ binding site [ion binding]; other site 707235005579 Hemerythrin-like domain; Region: Hr-like; cd12108 707235005580 Fe binding site [ion binding]; other site 707235005581 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005582 Ligand Binding Site [chemical binding]; other site 707235005583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005584 Ligand Binding Site [chemical binding]; other site 707235005585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 707235005586 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 707235005587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235005588 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 707235005589 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235005590 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 707235005591 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 707235005592 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 707235005593 tetramer interface [polypeptide binding]; other site 707235005594 active site 707235005595 Mg2+/Mn2+ binding site [ion binding]; other site 707235005596 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 707235005597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235005598 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 707235005599 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 707235005600 homotetramer interface [polypeptide binding]; other site 707235005601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 707235005602 NAD binding site [chemical binding]; other site 707235005603 homodimer interface [polypeptide binding]; other site 707235005604 active site 707235005605 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235005606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235005607 S-adenosylmethionine binding site [chemical binding]; other site 707235005608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 707235005609 Predicted kinase [General function prediction only]; Region: COG0645 707235005610 AAA domain; Region: AAA_17; pfam13207 707235005611 Universal stress protein family; Region: Usp; pfam00582 707235005612 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005613 Ligand Binding Site [chemical binding]; other site 707235005614 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 707235005615 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 707235005616 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 707235005617 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 707235005618 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 707235005619 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 707235005620 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 707235005621 Ferredoxin [Energy production and conversion]; Region: COG1146 707235005622 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 707235005623 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 707235005624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235005625 Walker A motif; other site 707235005626 ATP binding site [chemical binding]; other site 707235005627 Walker B motif; other site 707235005628 arginine finger; other site 707235005629 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235005630 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235005631 putative active site [active] 707235005632 Transcriptional regulators [Transcription]; Region: MarR; COG1846 707235005633 MarR family; Region: MarR_2; pfam12802 707235005634 Phage envelope protein [General function prediction only]; Region: COG5562 707235005635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 707235005636 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235005637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 707235005638 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 707235005639 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235005640 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235005641 active site 707235005642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235005643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235005644 non-specific DNA binding site [nucleotide binding]; other site 707235005645 salt bridge; other site 707235005646 sequence-specific DNA binding site [nucleotide binding]; other site 707235005647 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 707235005648 Uncharacterized conserved protein [Function unknown]; Region: COG2442 707235005649 Predicted helicase [General function prediction only]; Region: COG4889 707235005650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235005651 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 707235005652 non-specific DNA binding site [nucleotide binding]; other site 707235005653 salt bridge; other site 707235005654 sequence-specific DNA binding site [nucleotide binding]; other site 707235005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 707235005656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235005657 Transposase; Region: HTH_Tnp_1; cl17663 707235005658 putative transposase OrfB; Reviewed; Region: PHA02517 707235005659 HTH-like domain; Region: HTH_21; pfam13276 707235005660 Integrase core domain; Region: rve; pfam00665 707235005661 Integrase core domain; Region: rve_3; pfam13683 707235005662 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 707235005663 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 707235005664 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005665 Ligand Binding Site [chemical binding]; other site 707235005666 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005667 Ligand Binding Site [chemical binding]; other site 707235005668 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 707235005669 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 707235005670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 707235005671 Histidine kinase; Region: HisKA_3; pfam07730 707235005672 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235005673 Ligand Binding Site [chemical binding]; other site 707235005674 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 707235005675 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 707235005676 putative substrate binding site [chemical binding]; other site 707235005677 putative ATP binding site [chemical binding]; other site 707235005678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235005679 active site 707235005680 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 707235005681 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 707235005682 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 707235005683 putative dimer interface [polypeptide binding]; other site 707235005684 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 707235005685 dimer interface [polypeptide binding]; other site 707235005686 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 707235005687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235005688 putative DNA binding site [nucleotide binding]; other site 707235005689 dimerization interface [polypeptide binding]; other site 707235005690 putative Zn2+ binding site [ion binding]; other site 707235005691 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 707235005692 putative hydrophobic ligand binding site [chemical binding]; other site 707235005693 CLM binding site; other site 707235005694 L1 loop; other site 707235005695 DNA binding site [nucleotide binding] 707235005696 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235005697 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 707235005698 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 707235005699 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 707235005700 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 707235005701 nucleophile elbow; other site 707235005702 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 707235005703 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 707235005704 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 707235005705 Walker A/P-loop; other site 707235005706 ATP binding site [chemical binding]; other site 707235005707 Q-loop/lid; other site 707235005708 ABC transporter signature motif; other site 707235005709 Walker B; other site 707235005710 D-loop; other site 707235005711 H-loop/switch region; other site 707235005712 TOBE domain; Region: TOBE_2; pfam08402 707235005713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 707235005714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235005715 dimer interface [polypeptide binding]; other site 707235005716 conserved gate region; other site 707235005717 putative PBP binding loops; other site 707235005718 ABC-ATPase subunit interface; other site 707235005719 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 707235005720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235005721 dimer interface [polypeptide binding]; other site 707235005722 conserved gate region; other site 707235005723 putative PBP binding loops; other site 707235005724 ABC-ATPase subunit interface; other site 707235005725 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 707235005726 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 707235005727 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 707235005728 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 707235005729 Isochorismatase family; Region: Isochorismatase; pfam00857 707235005730 catalytic triad [active] 707235005731 metal binding site [ion binding]; metal-binding site 707235005732 conserved cis-peptide bond; other site 707235005733 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 707235005734 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 707235005735 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235005736 substrate binding pocket [chemical binding]; other site 707235005737 catalytic triad [active] 707235005738 hypothetical protein; Provisional; Region: PRK05865 707235005739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005740 NAD(P) binding site [chemical binding]; other site 707235005741 active site 707235005742 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 707235005743 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235005744 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235005745 active site 707235005746 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235005747 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235005748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005749 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235005750 Enoylreductase; Region: PKS_ER; smart00829 707235005751 NAD(P) binding site [chemical binding]; other site 707235005752 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 707235005753 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235005754 putative NADP binding site [chemical binding]; other site 707235005755 active site 707235005756 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235005757 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235005758 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235005759 active site 707235005760 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235005761 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235005762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005763 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235005764 Enoylreductase; Region: PKS_ER; smart00829 707235005765 NAD(P) binding site [chemical binding]; other site 707235005766 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 707235005767 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235005768 putative NADP binding site [chemical binding]; other site 707235005769 active site 707235005770 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235005771 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 707235005772 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 707235005773 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 707235005774 putative active site [active] 707235005775 catalytic triad [active] 707235005776 putative dimer interface [polypeptide binding]; other site 707235005777 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 707235005778 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 707235005779 Ligand binding site; other site 707235005780 Putative Catalytic site; other site 707235005781 DXD motif; other site 707235005782 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 707235005783 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 707235005784 active site 707235005785 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 707235005786 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 707235005787 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 707235005788 30S ribosomal protein S18; Provisional; Region: PRK13401 707235005789 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 707235005790 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 707235005791 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 707235005792 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 707235005793 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 707235005794 intersubunit interface [polypeptide binding]; other site 707235005795 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 707235005796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 707235005797 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 707235005798 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 707235005799 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 707235005800 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 707235005801 precorrin-3B synthase; Region: CobG; TIGR02435 707235005802 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 707235005803 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 707235005804 Precorrin-8X methylmutase; Region: CbiC; pfam02570 707235005805 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 707235005806 active site 707235005807 SAM binding site [chemical binding]; other site 707235005808 homodimer interface [polypeptide binding]; other site 707235005809 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 707235005810 active site 707235005811 SAM binding site [chemical binding]; other site 707235005812 homodimer interface [polypeptide binding]; other site 707235005813 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235005814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235005815 S-adenosylmethionine binding site [chemical binding]; other site 707235005816 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 707235005817 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 707235005818 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 707235005819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235005820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235005821 DNA binding residues [nucleotide binding] 707235005822 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 707235005823 precorrin-6x reductase; Region: precor6x_red; TIGR00715 707235005824 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 707235005825 active site 707235005826 SAM binding site [chemical binding]; other site 707235005827 homodimer interface [polypeptide binding]; other site 707235005828 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 707235005829 active site 707235005830 putative homodimer interface [polypeptide binding]; other site 707235005831 SAM binding site [chemical binding]; other site 707235005832 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 707235005833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235005834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235005835 NAD(P) binding site [chemical binding]; other site 707235005836 active site 707235005837 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 707235005838 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 707235005839 putative active site [active] 707235005840 catalytic site [active] 707235005841 putative metal binding site [ion binding]; other site 707235005842 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 707235005843 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 707235005844 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 707235005845 putative transposase OrfB; Reviewed; Region: PHA02517 707235005846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235005847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235005848 active site 707235005849 ATP binding site [chemical binding]; other site 707235005850 substrate binding site [chemical binding]; other site 707235005851 activation loop (A-loop); other site 707235005852 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235005853 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 707235005854 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 707235005855 active site 707235005856 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 707235005857 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 707235005858 active site 707235005859 metal binding site 1 [ion binding]; metal-binding site 707235005860 putative 5' ssDNA interaction site; other site 707235005861 metal binding site 3; metal-binding site 707235005862 metal binding site 2 [ion binding]; metal-binding site 707235005863 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 707235005864 putative DNA binding site [nucleotide binding]; other site 707235005865 putative metal binding site [ion binding]; other site 707235005866 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 707235005867 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 707235005868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235005869 ATP binding site [chemical binding]; other site 707235005870 putative Mg++ binding site [ion binding]; other site 707235005871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235005872 nucleotide binding region [chemical binding]; other site 707235005873 ATP-binding site [chemical binding]; other site 707235005874 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 707235005875 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 707235005876 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 707235005877 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 707235005878 Predicted transcriptional regulator [Transcription]; Region: COG2378 707235005879 WYL domain; Region: WYL; pfam13280 707235005880 Predicted transcriptional regulator [Transcription]; Region: COG2378 707235005881 WYL domain; Region: WYL; pfam13280 707235005882 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 707235005883 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235005884 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235005885 active site 707235005886 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 707235005887 SNF2 Helicase protein; Region: DUF3670; pfam12419 707235005888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235005889 ATP binding site [chemical binding]; other site 707235005890 putative Mg++ binding site [ion binding]; other site 707235005891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235005892 nucleotide binding region [chemical binding]; other site 707235005893 ATP-binding site [chemical binding]; other site 707235005894 Uncharacterized conserved protein [Function unknown]; Region: COG4279 707235005895 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235005896 putative active site [active] 707235005897 PE family; Region: PE; pfam00934 707235005898 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005899 PPE family; Region: PPE; pfam00823 707235005900 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 707235005901 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 707235005902 active site 707235005903 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 707235005904 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 707235005905 active site 707235005906 Pup-like protein; Region: Pup; pfam05639 707235005907 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 707235005908 proteasome ATPase; Region: pup_AAA; TIGR03689 707235005909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235005910 Walker A motif; other site 707235005911 ATP binding site [chemical binding]; other site 707235005912 Walker B motif; other site 707235005913 arginine finger; other site 707235005914 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 707235005915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 707235005916 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 707235005917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235005918 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 707235005919 Predicted membrane protein [Function unknown]; Region: COG3918 707235005920 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 707235005921 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 707235005922 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 707235005923 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 707235005924 homodimer interface [polypeptide binding]; other site 707235005925 putative metal binding site [ion binding]; other site 707235005926 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235005927 PPE family; Region: PPE; pfam00823 707235005928 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 707235005929 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 707235005930 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 707235005931 substrate binding pocket [chemical binding]; other site 707235005932 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 707235005933 B12 binding site [chemical binding]; other site 707235005934 cobalt ligand [ion binding]; other site 707235005935 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 707235005936 PAC2 family; Region: PAC2; pfam09754 707235005937 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 707235005938 short chain dehydrogenase; Provisional; Region: PRK05872 707235005939 classical (c) SDRs; Region: SDR_c; cd05233 707235005940 NAD(P) binding site [chemical binding]; other site 707235005941 active site 707235005942 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 707235005943 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 707235005944 active site 707235005945 HIGH motif; other site 707235005946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235005947 active site 707235005948 KMSKS motif; other site 707235005949 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 707235005950 putative tRNA binding surface [nucleotide binding]; other site 707235005951 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 707235005952 active site 707235005953 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235005954 conserved hypothetical protein; Region: TIGR03843 707235005955 conserved hypothetical protein; Region: TIGR03847 707235005956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235005957 catalytic core [active] 707235005958 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 707235005959 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 707235005960 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 707235005961 quinone interaction residues [chemical binding]; other site 707235005962 active site 707235005963 catalytic residues [active] 707235005964 FMN binding site [chemical binding]; other site 707235005965 substrate binding site [chemical binding]; other site 707235005966 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 707235005967 substrate binding site [chemical binding]; other site 707235005968 hypothetical protein; Provisional; Region: PRK07906 707235005969 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 707235005970 putative metal binding site [ion binding]; other site 707235005971 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 707235005972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235005973 active site 707235005974 DivIVA domain; Region: DivI1A_domain; TIGR03544 707235005975 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 707235005976 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 707235005977 Predicted integral membrane protein [Function unknown]; Region: COG0762 707235005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 707235005979 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 707235005980 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 707235005981 catalytic residue [active] 707235005982 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 707235005983 uncharacterized protein, YfiH family; Region: TIGR00726 707235005984 cell division protein FtsZ; Validated; Region: PRK09330 707235005985 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 707235005986 nucleotide binding site [chemical binding]; other site 707235005987 SulA interaction site; other site 707235005988 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 707235005989 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 707235005990 Cell division protein FtsQ; Region: FtsQ; pfam03799 707235005991 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 707235005992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 707235005993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707235005994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707235005995 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 707235005996 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 707235005997 active site 707235005998 homodimer interface [polypeptide binding]; other site 707235005999 cell division protein FtsW; Region: ftsW; TIGR02614 707235006000 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 707235006001 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707235006002 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707235006003 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 707235006004 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 707235006005 Mg++ binding site [ion binding]; other site 707235006006 putative catalytic motif [active] 707235006007 putative substrate binding site [chemical binding]; other site 707235006008 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 707235006009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707235006010 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707235006011 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 707235006012 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 707235006013 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707235006014 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707235006015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235006016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235006017 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 707235006018 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 707235006019 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235006020 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235006021 PE family; Region: PE; pfam00934 707235006022 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 707235006023 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 707235006024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 707235006025 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 707235006026 MraW methylase family; Region: Methyltransf_5; pfam01795 707235006027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 707235006028 MraZ protein; Region: MraZ; pfam02381 707235006029 MraZ protein; Region: MraZ; pfam02381 707235006030 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 707235006031 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 707235006032 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707235006033 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707235006034 substrate binding pocket [chemical binding]; other site 707235006035 chain length determination region; other site 707235006036 substrate-Mg2+ binding site; other site 707235006037 catalytic residues [active] 707235006038 aspartate-rich region 1; other site 707235006039 active site lid residues [active] 707235006040 aspartate-rich region 2; other site 707235006041 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 707235006042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235006043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235006044 active site 707235006045 ATP binding site [chemical binding]; other site 707235006046 substrate binding site [chemical binding]; other site 707235006047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 707235006048 substrate binding site [chemical binding]; other site 707235006049 activation loop (A-loop); other site 707235006050 activation loop (A-loop); other site 707235006051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 707235006052 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 707235006053 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 707235006054 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 707235006055 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235006056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235006057 putative acyl-acceptor binding pocket; other site 707235006058 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 707235006059 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 707235006060 DTAP/Switch II; other site 707235006061 Switch I; other site 707235006062 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 707235006063 putative hydrophobic ligand binding site [chemical binding]; other site 707235006064 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 707235006065 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 707235006066 acyl-activating enzyme (AAE) consensus motif; other site 707235006067 putative AMP binding site [chemical binding]; other site 707235006068 putative active site [active] 707235006069 putative CoA binding site [chemical binding]; other site 707235006070 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 707235006071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 707235006072 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 707235006073 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707235006074 NlpC/P60 family; Region: NLPC_P60; pfam00877 707235006075 hypothetical protein; Validated; Region: PRK07883 707235006076 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 707235006077 active site 707235006078 catalytic site [active] 707235006079 substrate binding site [chemical binding]; other site 707235006080 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 707235006081 GIY-YIG motif/motif A; other site 707235006082 active site 707235006083 catalytic site [active] 707235006084 putative DNA binding site [nucleotide binding]; other site 707235006085 metal binding site [ion binding]; metal-binding site 707235006086 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 707235006087 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 707235006088 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 707235006089 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 707235006090 Subunit I/III interface [polypeptide binding]; other site 707235006091 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 707235006092 Cytochrome c; Region: Cytochrom_C; pfam00034 707235006093 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 707235006094 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 707235006095 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 707235006096 iron-sulfur cluster [ion binding]; other site 707235006097 [2Fe-2S] cluster binding site [ion binding]; other site 707235006098 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 707235006099 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 707235006100 heme bH binding site [chemical binding]; other site 707235006101 intrachain domain interface; other site 707235006102 heme bL binding site [chemical binding]; other site 707235006103 interchain domain interface [polypeptide binding]; other site 707235006104 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 707235006105 Qo binding site; other site 707235006106 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 707235006107 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 707235006108 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 707235006109 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 707235006110 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 707235006111 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 707235006112 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 707235006113 dimer interface [polypeptide binding]; other site 707235006114 active site 707235006115 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 707235006116 Ligand Binding Site [chemical binding]; other site 707235006117 Molecular Tunnel; other site 707235006118 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 707235006119 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 707235006120 substrate binding site [chemical binding]; other site 707235006121 ATP binding site [chemical binding]; other site 707235006122 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 707235006123 Glycerate kinase family; Region: Gly_kinase; pfam02595 707235006124 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 707235006125 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 707235006126 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 707235006127 putative dimer interface [polypeptide binding]; other site 707235006128 active site pocket [active] 707235006129 putative cataytic base [active] 707235006130 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 707235006131 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 707235006132 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 707235006133 homodimer interface [polypeptide binding]; other site 707235006134 substrate-cofactor binding pocket; other site 707235006135 catalytic residue [active] 707235006136 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 707235006137 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 707235006138 cyclase homology domain; Region: CHD; cd07302 707235006139 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235006140 nucleotidyl binding site; other site 707235006141 metal binding site [ion binding]; metal-binding site 707235006142 dimer interface [polypeptide binding]; other site 707235006143 multifunctional aminopeptidase A; Provisional; Region: PRK00913 707235006144 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 707235006145 interface (dimer of trimers) [polypeptide binding]; other site 707235006146 Substrate-binding/catalytic site; other site 707235006147 Zn-binding sites [ion binding]; other site 707235006148 short chain dehydrogenase; Validated; Region: PRK05855 707235006149 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235006150 classical (c) SDRs; Region: SDR_c; cd05233 707235006151 NAD(P) binding site [chemical binding]; other site 707235006152 active site 707235006153 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 707235006154 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707235006155 E3 interaction surface; other site 707235006156 lipoyl attachment site [posttranslational modification]; other site 707235006157 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707235006158 E3 interaction surface; other site 707235006159 lipoyl attachment site [posttranslational modification]; other site 707235006160 e3 binding domain; Region: E3_binding; pfam02817 707235006161 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707235006162 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 707235006163 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 707235006164 putative NAD(P) binding site [chemical binding]; other site 707235006165 putative active site [active] 707235006166 lipoate-protein ligase B; Provisional; Region: PRK14345 707235006167 lipoyl synthase; Provisional; Region: PRK05481 707235006168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235006169 FeS/SAM binding site; other site 707235006170 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 707235006171 RDD family; Region: RDD; pfam06271 707235006172 glutamine synthetase, type I; Region: GlnA; TIGR00653 707235006173 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 707235006174 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 707235006175 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 707235006176 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 707235006177 metal binding triad; other site 707235006178 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 707235006179 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 707235006180 metal binding triad; other site 707235006181 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 707235006182 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 707235006183 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 707235006184 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 707235006185 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 707235006186 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235006187 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 707235006188 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235006189 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 707235006190 oligomerization interface [polypeptide binding]; other site 707235006191 active site 707235006192 metal binding site [ion binding]; metal-binding site 707235006193 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 707235006194 putative active site; other site 707235006195 putative metal binding residues [ion binding]; other site 707235006196 signature motif; other site 707235006197 putative triphosphate binding site [ion binding]; other site 707235006198 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 707235006199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 707235006200 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 707235006201 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 707235006202 RNA/DNA hybrid binding site [nucleotide binding]; other site 707235006203 active site 707235006204 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235006205 catalytic core [active] 707235006206 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 707235006207 Putative zinc ribbon domain; Region: DUF164; pfam02591 707235006208 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 707235006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 707235006210 Uncharacterized conserved protein [Function unknown]; Region: COG0327 707235006211 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 707235006212 hypothetical protein; Provisional; Region: PRK07908 707235006213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235006214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235006215 homodimer interface [polypeptide binding]; other site 707235006216 catalytic residue [active] 707235006217 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 707235006218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235006219 active site 707235006220 motif I; other site 707235006221 motif II; other site 707235006222 Low molecular weight phosphatase family; Region: LMWPc; cd00115 707235006223 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 707235006224 active site 707235006225 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 707235006226 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 707235006227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 707235006228 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 707235006229 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 707235006230 dimer interface [polypeptide binding]; other site 707235006231 catalytic triad [active] 707235006232 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 707235006233 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 707235006234 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 707235006235 dimer interface [polypeptide binding]; other site 707235006236 TPP-binding site [chemical binding]; other site 707235006237 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235006238 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 707235006239 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 707235006240 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235006241 acyl carrier protein; Provisional; Region: acpP; PRK00982 707235006242 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 707235006243 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 707235006244 dimer interface [polypeptide binding]; other site 707235006245 active site 707235006246 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 707235006247 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 707235006248 dimer interface [polypeptide binding]; other site 707235006249 active site 707235006250 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 707235006251 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 707235006252 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 707235006253 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235006254 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 707235006255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235006256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235006257 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235006258 FAD binding domain; Region: FAD_binding_4; pfam01565 707235006259 diacylglycerol kinase; Reviewed; Region: PRK11914 707235006260 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 707235006261 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 707235006262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235006263 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235006264 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235006265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235006266 S-adenosylmethionine binding site [chemical binding]; other site 707235006267 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 707235006268 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 707235006269 NAD binding site [chemical binding]; other site 707235006270 catalytic Zn binding site [ion binding]; other site 707235006271 substrate binding site [chemical binding]; other site 707235006272 structural Zn binding site [ion binding]; other site 707235006273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 707235006274 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 707235006275 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 707235006276 putative active site [active] 707235006277 catalytic triad [active] 707235006278 putative dimer interface [polypeptide binding]; other site 707235006279 short chain dehydrogenase; Provisional; Region: PRK05854 707235006280 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 707235006281 putative NAD(P) binding site [chemical binding]; other site 707235006282 active site 707235006283 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 707235006284 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235006285 nucleotide binding site [chemical binding]; other site 707235006286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235006287 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235006288 Cytochrome P450; Region: p450; cl12078 707235006289 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 707235006290 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235006291 Cytochrome P450; Region: p450; cl12078 707235006292 Septum formation; Region: Septum_form; pfam13845 707235006293 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 707235006294 Predicted membrane protein [Function unknown]; Region: COG2149 707235006295 Domain of unknown function (DUF202); Region: DUF202; pfam02656 707235006296 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235006297 Cytochrome P450; Region: p450; cl12078 707235006298 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 707235006299 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 707235006300 putative active site [active] 707235006301 catalytic site [active] 707235006302 putative metal binding site [ion binding]; other site 707235006303 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 707235006304 FAD binding domain; Region: FAD_binding_4; pfam01565 707235006305 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 707235006306 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 707235006307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 707235006308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 707235006309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 707235006310 dimerization interface [polypeptide binding]; other site 707235006311 putative transposase OrfB; Reviewed; Region: PHA02517 707235006312 HTH-like domain; Region: HTH_21; pfam13276 707235006313 Integrase core domain; Region: rve; pfam00665 707235006314 Integrase core domain; Region: rve_3; pfam13683 707235006315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235006316 Transposase; Region: HTH_Tnp_1; cl17663 707235006317 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235006318 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235006319 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235006320 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235006321 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235006322 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 707235006323 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 707235006324 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 707235006325 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 707235006326 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 707235006327 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 707235006328 active site residue [active] 707235006329 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 707235006330 active site residue [active] 707235006331 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 707235006332 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 707235006333 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 707235006334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235006335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235006336 homodimer interface [polypeptide binding]; other site 707235006337 catalytic residue [active] 707235006338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 707235006339 haloalkane dehalogenase; Provisional; Region: PRK00870 707235006340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 707235006341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 707235006342 active site 707235006343 catalytic tetrad [active] 707235006344 heat shock protein 90; Provisional; Region: PRK05218 707235006345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235006346 ATP binding site [chemical binding]; other site 707235006347 Mg2+ binding site [ion binding]; other site 707235006348 G-X-G motif; other site 707235006349 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 707235006350 Cutinase; Region: Cutinase; pfam01083 707235006351 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 707235006352 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 707235006353 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 707235006354 Uncharacterized conserved protein [Function unknown]; Region: COG0398 707235006355 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 707235006356 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 707235006357 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235006358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 707235006359 Uncharacterized conserved protein [Function unknown]; Region: COG2442 707235006360 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235006361 DNA binding site [nucleotide binding] 707235006362 active site 707235006363 Int/Topo IB signature motif; other site 707235006364 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 707235006365 DNA binding residues [nucleotide binding] 707235006366 Family description; Region: UvrD_C_2; pfam13538 707235006367 Uncharacterized conserved protein [Function unknown]; Region: COG2128 707235006368 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 707235006369 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 707235006370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235006371 putative PBP binding loops; other site 707235006372 ABC-ATPase subunit interface; other site 707235006373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 707235006374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235006375 dimer interface [polypeptide binding]; other site 707235006376 conserved gate region; other site 707235006377 putative PBP binding loops; other site 707235006378 ABC-ATPase subunit interface; other site 707235006379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 707235006380 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 707235006381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235006382 Ligand Binding Site [chemical binding]; other site 707235006383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235006384 Ligand Binding Site [chemical binding]; other site 707235006385 amino acid transporter; Region: 2A0306; TIGR00909 707235006386 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 707235006387 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 707235006388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235006389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235006390 catalytic residue [active] 707235006391 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235006392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235006393 Amidinotransferase; Region: Amidinotransf; pfam02274 707235006394 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 707235006395 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 707235006396 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 707235006397 putative DNA binding site [nucleotide binding]; other site 707235006398 putative Zn2+ binding site [ion binding]; other site 707235006399 AsnC family; Region: AsnC_trans_reg; pfam01037 707235006400 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 707235006401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 707235006402 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 707235006403 Walker A/P-loop; other site 707235006404 ATP binding site [chemical binding]; other site 707235006405 Q-loop/lid; other site 707235006406 ABC transporter signature motif; other site 707235006407 Walker B; other site 707235006408 D-loop; other site 707235006409 H-loop/switch region; other site 707235006410 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 707235006411 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 707235006412 Walker A/P-loop; other site 707235006413 ATP binding site [chemical binding]; other site 707235006414 Q-loop/lid; other site 707235006415 ABC transporter signature motif; other site 707235006416 Walker B; other site 707235006417 D-loop; other site 707235006418 H-loop/switch region; other site 707235006419 MarR family; Region: MarR; pfam01047 707235006420 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235006421 PE family; Region: PE; pfam00934 707235006422 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 707235006423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235006424 putative substrate translocation pore; other site 707235006425 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 707235006426 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 707235006427 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 707235006428 malate dehydrogenase; Provisional; Region: PRK13529 707235006429 Malic enzyme, N-terminal domain; Region: malic; pfam00390 707235006430 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 707235006431 NAD(P) binding site [chemical binding]; other site 707235006432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235006433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235006434 putative substrate translocation pore; other site 707235006435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235006436 putative substrate translocation pore; other site 707235006437 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 707235006438 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 707235006439 dimer interface [polypeptide binding]; other site 707235006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235006441 catalytic residue [active] 707235006442 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 707235006443 serine O-acetyltransferase; Region: cysE; TIGR01172 707235006444 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 707235006445 trimer interface [polypeptide binding]; other site 707235006446 active site 707235006447 substrate binding site [chemical binding]; other site 707235006448 CoA binding site [chemical binding]; other site 707235006449 hypothetical protein; Provisional; Region: PRK14851 707235006450 hypothetical protein; Validated; Region: PRK08223 707235006451 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 707235006452 ATP binding site [chemical binding]; other site 707235006453 substrate interface [chemical binding]; other site 707235006454 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235006455 PE family; Region: PE; pfam00934 707235006456 DNA primase; Validated; Region: dnaG; PRK05667 707235006457 CHC2 zinc finger; Region: zf-CHC2; pfam01807 707235006458 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 707235006459 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 707235006460 active site 707235006461 metal binding site [ion binding]; metal-binding site 707235006462 interdomain interaction site; other site 707235006463 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 707235006464 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 707235006465 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 707235006466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 707235006467 Zn2+ binding site [ion binding]; other site 707235006468 Mg2+ binding site [ion binding]; other site 707235006469 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 707235006470 Repair protein; Region: Repair_PSII; pfam04536 707235006471 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235006472 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 707235006473 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 707235006474 Phosphoesterase family; Region: Phosphoesterase; pfam04185 707235006475 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 707235006476 Phosphoesterase family; Region: Phosphoesterase; pfam04185 707235006477 putative transposase OrfB; Reviewed; Region: PHA02517 707235006478 HTH-like domain; Region: HTH_21; pfam13276 707235006479 Integrase core domain; Region: rve; pfam00665 707235006480 Integrase core domain; Region: rve_3; pfam13683 707235006481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235006482 Transposase; Region: HTH_Tnp_1; cl17663 707235006483 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235006484 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 707235006485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235006486 PPE family; Region: PPE; pfam00823 707235006487 PPE family; Region: PPE; pfam00823 707235006488 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235006489 PPE family; Region: PPE; pfam00823 707235006490 glycyl-tRNA synthetase; Provisional; Region: PRK04173 707235006491 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707235006492 motif 1; other site 707235006493 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 707235006494 active site 707235006495 motif 2; other site 707235006496 motif 3; other site 707235006497 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 707235006498 anticodon binding site; other site 707235006499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235006500 dimerization interface [polypeptide binding]; other site 707235006501 putative DNA binding site [nucleotide binding]; other site 707235006502 putative Zn2+ binding site [ion binding]; other site 707235006503 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 707235006504 metal binding site 2 [ion binding]; metal-binding site 707235006505 putative DNA binding helix; other site 707235006506 metal binding site 1 [ion binding]; metal-binding site 707235006507 dimer interface [polypeptide binding]; other site 707235006508 structural Zn2+ binding site [ion binding]; other site 707235006509 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 707235006510 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 707235006511 catalytic residue [active] 707235006512 putative FPP diphosphate binding site; other site 707235006513 putative FPP binding hydrophobic cleft; other site 707235006514 dimer interface [polypeptide binding]; other site 707235006515 putative IPP diphosphate binding site; other site 707235006516 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 707235006517 Recombination protein O N terminal; Region: RecO_N; pfam11967 707235006518 Recombination protein O C terminal; Region: RecO_C; pfam02565 707235006519 amidase; Provisional; Region: PRK06061 707235006520 Amidase; Region: Amidase; pfam01425 707235006521 GTPase Era; Reviewed; Region: era; PRK00089 707235006522 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 707235006523 G1 box; other site 707235006524 GTP/Mg2+ binding site [chemical binding]; other site 707235006525 Switch I region; other site 707235006526 G2 box; other site 707235006527 Switch II region; other site 707235006528 G3 box; other site 707235006529 G4 box; other site 707235006530 G5 box; other site 707235006531 KH domain; Region: KH_2; pfam07650 707235006532 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 707235006533 Domain of unknown function DUF21; Region: DUF21; pfam01595 707235006534 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707235006535 Transporter associated domain; Region: CorC_HlyC; smart01091 707235006536 metal-binding heat shock protein; Provisional; Region: PRK00016 707235006537 K homology RNA-binding domain; Region: KH; smart00322 707235006538 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 707235006539 PhoH-like protein; Region: PhoH; pfam02562 707235006540 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 707235006541 PE family; Region: PE; pfam00934 707235006542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 707235006543 RNA methyltransferase, RsmE family; Region: TIGR00046 707235006544 chaperone protein DnaJ; Provisional; Region: PRK14278 707235006545 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 707235006546 HSP70 interaction site [polypeptide binding]; other site 707235006547 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 707235006548 Zn binding sites [ion binding]; other site 707235006549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 707235006550 dimer interface [polypeptide binding]; other site 707235006551 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 707235006552 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235006553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 707235006554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235006555 Condensation domain; Region: Condensation; pfam00668 707235006556 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235006557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 707235006558 acyl-activating enzyme (AAE) consensus motif; other site 707235006559 AMP binding site [chemical binding]; other site 707235006560 Condensation domain; Region: Condensation; pfam00668 707235006561 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 707235006562 Condensation domain; Region: Condensation; pfam00668 707235006563 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235006564 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 707235006565 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 707235006566 acyl-activating enzyme (AAE) consensus motif; other site 707235006567 AMP binding site [chemical binding]; other site 707235006568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235006569 Condensation domain; Region: Condensation; pfam00668 707235006570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235006571 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 707235006572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235006573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235006574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235006575 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235006576 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 707235006577 NADP binding site [chemical binding]; other site 707235006578 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235006579 active site 707235006580 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235006581 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235006582 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 707235006583 active site 707235006584 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 707235006585 Condensation domain; Region: Condensation; pfam00668 707235006586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 707235006587 Nonribosomal peptide synthase; Region: NRPS; pfam08415 707235006588 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 707235006589 acyl-activating enzyme (AAE) consensus motif; other site 707235006590 AMP binding site [chemical binding]; other site 707235006591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235006592 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 707235006593 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 707235006594 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 707235006595 acyl-activating enzyme (AAE) consensus motif; other site 707235006596 active site 707235006597 AMP binding site [chemical binding]; other site 707235006598 substrate binding site [chemical binding]; other site 707235006599 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 707235006600 salicylate synthase MbtI; Reviewed; Region: PRK07912 707235006601 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 707235006602 Predicted permease [General function prediction only]; Region: COG3329 707235006603 coproporphyrinogen III oxidase; Validated; Region: PRK05628 707235006604 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 707235006605 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 707235006606 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 707235006607 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 707235006608 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 707235006609 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 707235006610 Active Sites [active] 707235006611 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 707235006612 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 707235006613 putative active site [active] 707235006614 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 707235006615 putative active site [active] 707235006616 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 707235006617 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 707235006618 Predicted membrane protein [Function unknown]; Region: COG1297 707235006619 putative oligopeptide transporter, OPT family; Region: TIGR00733 707235006620 PE family; Region: PE; pfam00934 707235006621 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 707235006622 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 707235006623 Walker A/P-loop; other site 707235006624 ATP binding site [chemical binding]; other site 707235006625 Q-loop/lid; other site 707235006626 ABC transporter signature motif; other site 707235006627 Walker B; other site 707235006628 D-loop; other site 707235006629 H-loop/switch region; other site 707235006630 sulfate transport protein; Provisional; Region: cysT; CHL00187 707235006631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235006632 dimer interface [polypeptide binding]; other site 707235006633 conserved gate region; other site 707235006634 putative PBP binding loops; other site 707235006635 ABC-ATPase subunit interface; other site 707235006636 sulfate transport protein; Provisional; Region: cysT; CHL00187 707235006637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235006638 dimer interface [polypeptide binding]; other site 707235006639 conserved gate region; other site 707235006640 putative PBP binding loops; other site 707235006641 ABC-ATPase subunit interface; other site 707235006642 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 707235006643 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 707235006644 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 707235006645 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 707235006646 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235006647 GTP-binding protein LepA; Provisional; Region: PRK05433 707235006648 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 707235006649 G1 box; other site 707235006650 putative GEF interaction site [polypeptide binding]; other site 707235006651 GTP/Mg2+ binding site [chemical binding]; other site 707235006652 Switch I region; other site 707235006653 G2 box; other site 707235006654 G3 box; other site 707235006655 Switch II region; other site 707235006656 G4 box; other site 707235006657 G5 box; other site 707235006658 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 707235006659 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 707235006660 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 707235006661 PemK-like protein; Region: PemK; pfam02452 707235006662 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 707235006663 FOG: CBS domain [General function prediction only]; Region: COG0517 707235006664 ribonuclease Z; Reviewed; Region: PRK00055 707235006665 PE family; Region: PE; pfam00934 707235006666 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 707235006667 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 707235006668 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 707235006669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 707235006670 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 707235006671 Uncharacterized conserved protein [Function unknown]; Region: COG2308 707235006672 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 707235006673 hypothetical protein; Reviewed; Region: PRK07914 707235006674 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 707235006675 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 707235006676 Competence protein; Region: Competence; pfam03772 707235006677 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 707235006678 Helix-hairpin-helix motif; Region: HHH; pfam00633 707235006679 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 707235006680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235006681 Coenzyme A binding pocket [chemical binding]; other site 707235006682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 707235006683 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 707235006684 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 707235006685 active site 707235006686 catalytic triad [active] 707235006687 oxyanion hole [active] 707235006688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235006689 catalytic core [active] 707235006690 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 707235006691 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 707235006692 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 707235006693 active site 707235006694 (T/H)XGH motif; other site 707235006695 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235006696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235006697 S-adenosylmethionine binding site [chemical binding]; other site 707235006698 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235006699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 707235006700 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 707235006701 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 707235006702 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 707235006703 metal ion-dependent adhesion site (MIDAS); other site 707235006704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 707235006705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235006706 Walker A motif; other site 707235006707 ATP binding site [chemical binding]; other site 707235006708 Walker B motif; other site 707235006709 arginine finger; other site 707235006710 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 707235006711 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 707235006712 putative catalytic cysteine [active] 707235006713 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 707235006714 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 707235006715 dimer interface [polypeptide binding]; other site 707235006716 decamer (pentamer of dimers) interface [polypeptide binding]; other site 707235006717 catalytic triad [active] 707235006718 peroxidatic and resolving cysteines [active] 707235006719 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 707235006720 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 707235006721 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235006722 PPE family; Region: PPE; pfam00823 707235006723 PE family; Region: PE; pfam00934 707235006724 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 707235006725 Mechanosensitive ion channel; Region: MS_channel; pfam00924 707235006726 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235006727 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235006728 ligand binding site [chemical binding]; other site 707235006729 flexible hinge region; other site 707235006730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235006731 dimerization interface [polypeptide binding]; other site 707235006732 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 707235006733 cyclase homology domain; Region: CHD; cd07302 707235006734 nucleotidyl binding site; other site 707235006735 metal binding site [ion binding]; metal-binding site 707235006736 dimer interface [polypeptide binding]; other site 707235006737 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 707235006738 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 707235006739 substrate binding site [chemical binding]; other site 707235006740 dimer interface [polypeptide binding]; other site 707235006741 ATP binding site [chemical binding]; other site 707235006742 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 707235006743 NAD synthetase; Reviewed; Region: nadE; PRK02628 707235006744 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 707235006745 multimer interface [polypeptide binding]; other site 707235006746 active site 707235006747 catalytic triad [active] 707235006748 protein interface 1 [polypeptide binding]; other site 707235006749 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 707235006750 homodimer interface [polypeptide binding]; other site 707235006751 NAD binding pocket [chemical binding]; other site 707235006752 ATP binding pocket [chemical binding]; other site 707235006753 Mg binding site [ion binding]; other site 707235006754 active-site loop [active] 707235006755 gamma-glutamyl kinase; Provisional; Region: PRK05429 707235006756 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 707235006757 nucleotide binding site [chemical binding]; other site 707235006758 homotetrameric interface [polypeptide binding]; other site 707235006759 putative phosphate binding site [ion binding]; other site 707235006760 putative allosteric binding site; other site 707235006761 PUA domain; Region: PUA; pfam01472 707235006762 GTPase CgtA; Reviewed; Region: obgE; PRK12296 707235006763 GTP1/OBG; Region: GTP1_OBG; pfam01018 707235006764 Obg GTPase; Region: Obg; cd01898 707235006765 G1 box; other site 707235006766 GTP/Mg2+ binding site [chemical binding]; other site 707235006767 Switch I region; other site 707235006768 G2 box; other site 707235006769 G3 box; other site 707235006770 Switch II region; other site 707235006771 G4 box; other site 707235006772 G5 box; other site 707235006773 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 707235006774 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 707235006775 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 707235006776 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 707235006777 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 707235006778 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 707235006779 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 707235006780 homodimer interface [polypeptide binding]; other site 707235006781 oligonucleotide binding site [chemical binding]; other site 707235006782 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 707235006783 active site 707235006784 multimer interface [polypeptide binding]; other site 707235006785 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 707235006786 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 707235006787 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707235006788 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 707235006789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235006790 active site 707235006791 HIGH motif; other site 707235006792 nucleotide binding site [chemical binding]; other site 707235006793 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 707235006794 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 707235006795 active site 707235006796 KMSKS motif; other site 707235006797 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 707235006798 tRNA binding surface [nucleotide binding]; other site 707235006799 anticodon binding site; other site 707235006800 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 707235006801 Uncharacterized conserved protein [Function unknown]; Region: COG3268 707235006802 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 707235006803 NAD(P) binding pocket [chemical binding]; other site 707235006804 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 707235006805 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 707235006806 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 707235006807 GTP binding site; other site 707235006808 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 707235006809 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 707235006810 TPP-binding site [chemical binding]; other site 707235006811 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 707235006812 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 707235006813 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 707235006814 dimer interface [polypeptide binding]; other site 707235006815 PYR/PP interface [polypeptide binding]; other site 707235006816 TPP binding site [chemical binding]; other site 707235006817 substrate binding site [chemical binding]; other site 707235006818 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 707235006819 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 707235006820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235006821 Walker A motif; other site 707235006822 ATP binding site [chemical binding]; other site 707235006823 Walker B motif; other site 707235006824 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 707235006825 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 707235006826 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 707235006827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235006828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235006829 putative substrate translocation pore; other site 707235006830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235006831 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 707235006832 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 707235006833 oligomer interface [polypeptide binding]; other site 707235006834 active site residues [active] 707235006835 Clp protease; Region: CLP_protease; pfam00574 707235006836 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 707235006837 oligomer interface [polypeptide binding]; other site 707235006838 active site residues [active] 707235006839 trigger factor; Provisional; Region: tig; PRK01490 707235006840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 707235006841 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 707235006842 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235006843 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235006844 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 707235006845 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 707235006846 putative DNA binding site [nucleotide binding]; other site 707235006847 catalytic residue [active] 707235006848 putative H2TH interface [polypeptide binding]; other site 707235006849 putative catalytic residues [active] 707235006850 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 707235006851 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 707235006852 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 707235006853 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 707235006854 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 707235006855 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 707235006856 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 707235006857 Zn binding site [ion binding]; other site 707235006858 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 707235006859 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235006860 active site 707235006861 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 707235006862 apolar tunnel; other site 707235006863 heme binding site [chemical binding]; other site 707235006864 dimerization interface [polypeptide binding]; other site 707235006865 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 707235006866 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 707235006867 active site 707235006868 catalytic site [active] 707235006869 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 707235006870 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 707235006871 active site 707235006872 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 707235006873 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 707235006874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235006875 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235006876 ABC transporter; Region: ABC_tran_2; pfam12848 707235006877 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707235006878 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 707235006879 dimer interface [polypeptide binding]; other site 707235006880 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 707235006881 ssDNA binding site [nucleotide binding]; other site 707235006882 tetramer (dimer of dimers) interface [polypeptide binding]; other site 707235006883 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 707235006884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 707235006885 putative acyl-acceptor binding pocket; other site 707235006886 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 707235006887 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 707235006888 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235006889 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235006890 putative acyl-acceptor binding pocket; other site 707235006891 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235006892 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235006893 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 707235006894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235006895 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235006896 enoyl-CoA hydratase; Provisional; Region: PRK05870 707235006897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235006898 substrate binding site [chemical binding]; other site 707235006899 oxyanion hole (OAH) forming residues; other site 707235006900 trimer interface [polypeptide binding]; other site 707235006901 PE family; Region: PE; pfam00934 707235006902 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235006903 cyclase homology domain; Region: CHD; cd07302 707235006904 nucleotidyl binding site; other site 707235006905 metal binding site [ion binding]; metal-binding site 707235006906 dimer interface [polypeptide binding]; other site 707235006907 Predicted ATPase [General function prediction only]; Region: COG3903 707235006908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235006909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235006910 DNA binding residues [nucleotide binding] 707235006911 dimerization interface [polypeptide binding]; other site 707235006912 PE family; Region: PE; pfam00934 707235006913 TIGR00725 family protein; Region: TIGR00725 707235006914 thymidylate synthase; Provisional; Region: thyA; PRK00956 707235006915 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235006916 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 707235006917 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707235006918 E3 interaction surface; other site 707235006919 lipoyl attachment site [posttranslational modification]; other site 707235006920 e3 binding domain; Region: E3_binding; pfam02817 707235006921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707235006922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 707235006923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 707235006924 alpha subunit interface [polypeptide binding]; other site 707235006925 TPP binding site [chemical binding]; other site 707235006926 heterodimer interface [polypeptide binding]; other site 707235006927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707235006928 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 707235006929 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 707235006930 tetramer interface [polypeptide binding]; other site 707235006931 TPP-binding site [chemical binding]; other site 707235006932 heterodimer interface [polypeptide binding]; other site 707235006933 phosphorylation loop region [posttranslational modification] 707235006934 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 707235006935 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 707235006936 putative active site [active] 707235006937 putative catalytic site [active] 707235006938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235006939 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235006940 active site 707235006941 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 707235006942 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235006943 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 707235006944 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 707235006945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707235006946 carboxyltransferase (CT) interaction site; other site 707235006947 biotinylation site [posttranslational modification]; other site 707235006948 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 707235006949 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 707235006950 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 707235006951 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 707235006952 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 707235006953 AMP-binding domain protein; Validated; Region: PRK08315 707235006954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235006955 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 707235006956 acyl-activating enzyme (AAE) consensus motif; other site 707235006957 acyl-activating enzyme (AAE) consensus motif; other site 707235006958 putative AMP binding site [chemical binding]; other site 707235006959 putative active site [active] 707235006960 putative CoA binding site [chemical binding]; other site 707235006961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235006962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235006963 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 707235006964 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 707235006965 classical (c) SDRs; Region: SDR_c; cd05233 707235006966 NAD(P) binding site [chemical binding]; other site 707235006967 active site 707235006968 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 707235006969 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 707235006970 catalytic site [active] 707235006971 putative active site [active] 707235006972 putative substrate binding site [chemical binding]; other site 707235006973 dimer interface [polypeptide binding]; other site 707235006974 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235006975 MULE transposase domain; Region: MULE; pfam10551 707235006976 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 707235006977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235006978 non-specific DNA binding site [nucleotide binding]; other site 707235006979 salt bridge; other site 707235006980 sequence-specific DNA binding site [nucleotide binding]; other site 707235006981 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 707235006982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 707235006983 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 707235006984 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 707235006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 707235006986 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 707235006987 PE family; Region: PE; pfam00934 707235006988 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 707235006989 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 707235006990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235006991 catalytic triad [active] 707235006992 hypothetical protein; Provisional; Region: PRK07907 707235006993 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 707235006994 active site 707235006995 metal binding site [ion binding]; metal-binding site 707235006996 dimer interface [polypeptide binding]; other site 707235006997 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 707235006998 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 707235006999 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 707235007000 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235007001 phosphate binding site [ion binding]; other site 707235007002 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 707235007003 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 707235007004 putative active site [active] 707235007005 putative catalytic site [active] 707235007006 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 707235007007 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235007008 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 707235007009 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 707235007010 putative NAD(P) binding site [chemical binding]; other site 707235007011 active site 707235007012 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 707235007013 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 707235007014 active site 707235007015 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 707235007016 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235007017 putative active site [active] 707235007018 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 707235007019 Mrr N-terminal domain; Region: Mrr_N; pfam14338 707235007020 Restriction endonuclease; Region: Mrr_cat; pfam04471 707235007021 ERCC4 domain; Region: ERCC4; pfam02732 707235007022 Lsr2; Region: Lsr2; pfam11774 707235007023 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235007024 putative active site [active] 707235007025 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 707235007026 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235007027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235007028 catalytic residue [active] 707235007029 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 707235007030 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 707235007031 putative RNA binding site [nucleotide binding]; other site 707235007032 elongation factor P; Validated; Region: PRK00529 707235007033 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 707235007034 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 707235007035 RNA binding site [nucleotide binding]; other site 707235007036 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 707235007037 RNA binding site [nucleotide binding]; other site 707235007038 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 707235007039 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 707235007040 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 707235007041 active site 707235007042 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 707235007043 Dehydroquinase class II; Region: DHquinase_II; pfam01220 707235007044 trimer interface [polypeptide binding]; other site 707235007045 active site 707235007046 dimer interface [polypeptide binding]; other site 707235007047 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 707235007048 active site 707235007049 dimer interface [polypeptide binding]; other site 707235007050 metal binding site [ion binding]; metal-binding site 707235007051 shikimate kinase; Reviewed; Region: aroK; PRK00131 707235007052 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 707235007053 ADP binding site [chemical binding]; other site 707235007054 magnesium binding site [ion binding]; other site 707235007055 putative shikimate binding site; other site 707235007056 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 707235007057 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 707235007058 Tetramer interface [polypeptide binding]; other site 707235007059 active site 707235007060 FMN-binding site [chemical binding]; other site 707235007061 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 707235007062 digalactosyldiacylglycerol synthase; Region: PLN02846 707235007063 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235007064 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235007065 putative active site [active] 707235007066 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235007067 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 707235007068 oligomeric interface; other site 707235007069 putative active site [active] 707235007070 homodimer interface [polypeptide binding]; other site 707235007071 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 707235007072 putative active site [active] 707235007073 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235007074 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 707235007075 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 707235007076 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 707235007077 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 707235007078 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 707235007079 NAD(P) binding site [chemical binding]; other site 707235007080 shikimate binding site; other site 707235007081 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 707235007082 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 707235007083 dimerization interface [polypeptide binding]; other site 707235007084 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 707235007085 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 707235007086 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 707235007087 motif 1; other site 707235007088 active site 707235007089 motif 2; other site 707235007090 motif 3; other site 707235007091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 707235007092 DHHA1 domain; Region: DHHA1; pfam02272 707235007093 Uncharacterized conserved protein [Function unknown]; Region: COG0432 707235007094 recombination factor protein RarA; Reviewed; Region: PRK13342 707235007095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235007096 Walker A motif; other site 707235007097 ATP binding site [chemical binding]; other site 707235007098 Walker B motif; other site 707235007099 arginine finger; other site 707235007100 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 707235007101 Predicted integral membrane protein [Function unknown]; Region: COG5473 707235007102 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 707235007103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 707235007104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 707235007105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707235007106 Walker A/P-loop; other site 707235007107 ATP binding site [chemical binding]; other site 707235007108 Q-loop/lid; other site 707235007109 ABC transporter signature motif; other site 707235007110 Walker B; other site 707235007111 D-loop; other site 707235007112 H-loop/switch region; other site 707235007113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235007114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235007115 ligand binding site [chemical binding]; other site 707235007116 flexible hinge region; other site 707235007117 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235007118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235007119 ligand binding site [chemical binding]; other site 707235007120 flexible hinge region; other site 707235007121 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 707235007122 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 707235007123 active site 707235007124 nucleophile elbow; other site 707235007125 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 707235007126 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 707235007127 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 707235007128 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 707235007129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 707235007130 Uncharacterized conserved protein [Function unknown]; Region: COG2308 707235007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 707235007132 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 707235007133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 707235007134 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 707235007135 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 707235007136 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 707235007137 Transglutaminase/protease-like homologues; Region: TGc; smart00460 707235007138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 707235007139 Predicted membrane protein [Function unknown]; Region: COG4129 707235007140 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 707235007141 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 707235007142 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 707235007143 dimer interface [polypeptide binding]; other site 707235007144 anticodon binding site; other site 707235007145 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 707235007146 homodimer interface [polypeptide binding]; other site 707235007147 motif 1; other site 707235007148 active site 707235007149 motif 2; other site 707235007150 GAD domain; Region: GAD; pfam02938 707235007151 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707235007152 active site 707235007153 motif 3; other site 707235007154 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 707235007155 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 707235007156 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 707235007157 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 707235007158 putative hydrophobic ligand binding site [chemical binding]; other site 707235007159 protein interface [polypeptide binding]; other site 707235007160 gate; other site 707235007161 Predicted metalloprotease [General function prediction only]; Region: COG2321 707235007162 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 707235007163 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 707235007164 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 707235007165 active site 707235007166 metal binding site [ion binding]; metal-binding site 707235007167 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 707235007168 haloalkane dehalogenase; Provisional; Region: PRK03592 707235007169 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 707235007170 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 707235007171 dimer interface [polypeptide binding]; other site 707235007172 motif 1; other site 707235007173 active site 707235007174 motif 2; other site 707235007175 motif 3; other site 707235007176 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 707235007177 anticodon binding site; other site 707235007178 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 707235007179 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 707235007180 active site 707235007181 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 707235007182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 707235007183 Zn2+ binding site [ion binding]; other site 707235007184 Mg2+ binding site [ion binding]; other site 707235007185 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 707235007186 synthetase active site [active] 707235007187 NTP binding site [chemical binding]; other site 707235007188 metal binding site [ion binding]; metal-binding site 707235007189 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 707235007190 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 707235007191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235007192 active site 707235007193 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 707235007194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 707235007195 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 707235007196 Protein export membrane protein; Region: SecD_SecF; pfam02355 707235007197 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 707235007198 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 707235007199 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 707235007200 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 707235007201 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707235007202 inhibitor-cofactor binding pocket; inhibition site 707235007203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235007204 catalytic residue [active] 707235007205 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 707235007206 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235007207 acyl-activating enzyme (AAE) consensus motif; other site 707235007208 AMP binding site [chemical binding]; other site 707235007209 active site 707235007210 CoA binding site [chemical binding]; other site 707235007211 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 707235007212 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 707235007213 putative NAD(P) binding site [chemical binding]; other site 707235007214 active site 707235007215 putative substrate binding site [chemical binding]; other site 707235007216 PE family; Region: PE; pfam00934 707235007217 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 707235007218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235007219 Walker A motif; other site 707235007220 ATP binding site [chemical binding]; other site 707235007221 Walker B motif; other site 707235007222 arginine finger; other site 707235007223 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 707235007224 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 707235007225 RuvA N terminal domain; Region: RuvA_N; pfam01330 707235007226 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 707235007227 active site 707235007228 putative DNA-binding cleft [nucleotide binding]; other site 707235007229 dimer interface [polypeptide binding]; other site 707235007230 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 707235007231 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 707235007232 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235007233 putative active site [active] 707235007234 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 707235007235 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 707235007236 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 707235007237 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 707235007238 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 707235007239 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 707235007240 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 707235007241 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235007242 hypothetical protein; Validated; Region: PRK00110 707235007243 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 707235007244 predicted active site [active] 707235007245 catalytic triad [active] 707235007246 acyl-CoA thioesterase II; Region: tesB; TIGR00189 707235007247 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 707235007248 active site 707235007249 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 707235007250 catalytic triad [active] 707235007251 dimer interface [polypeptide binding]; other site 707235007252 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 707235007253 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 707235007254 active site 707235007255 multimer interface [polypeptide binding]; other site 707235007256 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 707235007257 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 707235007258 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 707235007259 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235007260 PPE family; Region: PPE; pfam00823 707235007261 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235007262 PE-PPE domain; Region: PE-PPE; pfam08237 707235007263 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 707235007264 nudix motif; other site 707235007265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 707235007266 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 707235007267 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 707235007268 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 707235007269 putative acyl-acceptor binding pocket; other site 707235007270 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 707235007271 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 707235007272 nucleotide binding site/active site [active] 707235007273 HIT family signature motif; other site 707235007274 catalytic residue [active] 707235007275 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 707235007276 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 707235007277 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 707235007278 active site 707235007279 dimer interface [polypeptide binding]; other site 707235007280 motif 1; other site 707235007281 motif 2; other site 707235007282 motif 3; other site 707235007283 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 707235007284 anticodon binding site; other site 707235007285 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235007286 phosphate binding site [ion binding]; other site 707235007287 PE family; Region: PE; pfam00934 707235007288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 707235007289 Predicted transcriptional regulator [Transcription]; Region: COG2345 707235007290 Helix-turn-helix domain; Region: HTH_20; pfam12840 707235007291 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 707235007292 Predicted transcriptional regulator [Transcription]; Region: COG2345 707235007293 Helix-turn-helix domain; Region: HTH_20; pfam12840 707235007294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235007295 S-adenosylmethionine binding site [chemical binding]; other site 707235007296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235007297 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235007298 Ligand Binding Site [chemical binding]; other site 707235007299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235007300 Ligand Binding Site [chemical binding]; other site 707235007301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235007302 Ligand Binding Site [chemical binding]; other site 707235007303 Universal stress protein family; Region: Usp; pfam00582 707235007304 Ligand Binding Site [chemical binding]; other site 707235007305 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 707235007306 active site 707235007307 Peptidase family M50; Region: Peptidase_M50; pfam02163 707235007308 putative substrate binding region [chemical binding]; other site 707235007309 FOG: CBS domain [General function prediction only]; Region: COG0517 707235007310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 707235007311 FOG: CBS domain [General function prediction only]; Region: COG0517 707235007312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 707235007313 peptide chain release factor 1; Provisional; Region: PRK04011 707235007314 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 707235007315 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 707235007316 hypothetical protein; Reviewed; Region: PRK09588 707235007317 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 707235007318 Hemerythrin-like domain; Region: Hr-like; cd12108 707235007319 Fe binding site [ion binding]; other site 707235007320 PE family; Region: PE; pfam00934 707235007321 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 707235007322 P-loop motif; other site 707235007323 ATP binding site [chemical binding]; other site 707235007324 Chloramphenicol (Cm) binding site [chemical binding]; other site 707235007325 catalytic residue [active] 707235007326 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 707235007327 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 707235007328 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235007329 anti sigma factor interaction site; other site 707235007330 regulatory phosphorylation site [posttranslational modification]; other site 707235007331 hypothetical protein; Provisional; Region: PRK02237 707235007332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235007333 Transcriptional regulators [Transcription]; Region: MarR; COG1846 707235007334 putative DNA binding site [nucleotide binding]; other site 707235007335 putative Zn2+ binding site [ion binding]; other site 707235007336 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 707235007337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 707235007338 putative metal binding site [ion binding]; other site 707235007339 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235007340 dimerization interface [polypeptide binding]; other site 707235007341 putative DNA binding site [nucleotide binding]; other site 707235007342 putative Zn2+ binding site [ion binding]; other site 707235007343 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 707235007344 arsenical-resistance protein; Region: acr3; TIGR00832 707235007345 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 707235007346 Low molecular weight phosphatase family; Region: LMWPc; cd00115 707235007347 active site 707235007348 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 707235007349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235007350 active site 707235007351 DNA binding site [nucleotide binding] 707235007352 Int/Topo IB signature motif; other site 707235007353 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 707235007354 Phage capsid family; Region: Phage_capsid; pfam05065 707235007355 Phage head maturation protease [General function prediction only]; Region: COG3740 707235007356 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 707235007357 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 707235007358 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 707235007359 DNA binding domain, excisionase family; Region: excise; TIGR01764 707235007360 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 707235007361 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 707235007362 active site 707235007363 catalytic residues [active] 707235007364 DNA binding site [nucleotide binding] 707235007365 Int/Topo IB signature motif; other site 707235007366 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235007367 MULE transposase domain; Region: MULE; pfam10551 707235007368 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 707235007369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 707235007370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235007371 Coenzyme A binding pocket [chemical binding]; other site 707235007372 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 707235007373 hypothetical protein; Provisional; Region: PRK14059 707235007374 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 707235007375 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235007376 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235007377 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 707235007378 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 707235007379 SelR domain; Region: SelR; pfam01641 707235007380 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235007381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235007382 S-adenosylmethionine binding site [chemical binding]; other site 707235007383 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 707235007384 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 707235007385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235007386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235007387 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 707235007388 substrate binding site [chemical binding]; other site 707235007389 active site 707235007390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235007391 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235007392 substrate binding site [chemical binding]; other site 707235007393 oxyanion hole (OAH) forming residues; other site 707235007394 trimer interface [polypeptide binding]; other site 707235007395 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 707235007396 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 707235007397 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 707235007398 catalytic site [active] 707235007399 putative active site [active] 707235007400 putative substrate binding site [chemical binding]; other site 707235007401 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 707235007402 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 707235007403 TPP-binding site; other site 707235007404 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 707235007405 PYR/PP interface [polypeptide binding]; other site 707235007406 dimer interface [polypeptide binding]; other site 707235007407 TPP binding site [chemical binding]; other site 707235007408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707235007409 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 707235007410 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 707235007411 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 707235007412 transmembrane helices; other site 707235007413 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 707235007414 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 707235007415 transmembrane helices; other site 707235007416 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 707235007417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 707235007418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 707235007419 Walker A/P-loop; other site 707235007420 ATP binding site [chemical binding]; other site 707235007421 Q-loop/lid; other site 707235007422 ABC transporter signature motif; other site 707235007423 Walker B; other site 707235007424 D-loop; other site 707235007425 H-loop/switch region; other site 707235007426 TRAM domain; Region: TRAM; cl01282 707235007427 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 707235007428 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 707235007429 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 707235007430 TrkA-N domain; Region: TrkA_N; pfam02254 707235007431 TrkA-C domain; Region: TrkA_C; pfam02080 707235007432 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 707235007433 TrkA-N domain; Region: TrkA_N; pfam02254 707235007434 TrkA-C domain; Region: TrkA_C; pfam02080 707235007435 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 707235007436 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 707235007437 generic binding surface II; other site 707235007438 ssDNA binding site; other site 707235007439 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 707235007440 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 707235007441 trimer interface [polypeptide binding]; other site 707235007442 active site 707235007443 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 707235007444 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 707235007445 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 707235007446 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 707235007447 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 707235007448 active site 707235007449 dimerization interface [polypeptide binding]; other site 707235007450 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 707235007451 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235007452 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 707235007453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235007454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 707235007455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235007456 DNA binding residues [nucleotide binding] 707235007457 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 707235007458 homotrimer interaction site [polypeptide binding]; other site 707235007459 putative active site [active] 707235007460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 707235007461 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 707235007462 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 707235007463 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 707235007464 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 707235007465 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 707235007466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235007467 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 707235007468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235007469 DNA binding residues [nucleotide binding] 707235007470 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 707235007471 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 707235007472 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 707235007473 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 707235007474 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 707235007475 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 707235007476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235007477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235007478 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707235007479 PAC2 family; Region: PAC2; pfam09754 707235007480 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235007481 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 707235007482 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 707235007483 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 707235007484 heme-binding site [chemical binding]; other site 707235007485 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 707235007486 ATP cone domain; Region: ATP-cone; pfam03477 707235007487 LysM domain; Region: LysM; pfam01476 707235007488 LexA repressor; Validated; Region: PRK00215 707235007489 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 707235007490 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 707235007491 Catalytic site [active] 707235007492 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 707235007493 LGFP repeat; Region: LGFP; pfam08310 707235007494 LGFP repeat; Region: LGFP; pfam08310 707235007495 LGFP repeat; Region: LGFP; pfam08310 707235007496 LGFP repeat; Region: LGFP; pfam08310 707235007497 LGFP repeat; Region: LGFP; pfam08310 707235007498 Integral membrane protein TerC family; Region: TerC; cl10468 707235007499 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235007500 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235007501 active site 707235007502 GTPases [General function prediction only]; Region: HflX; COG2262 707235007503 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 707235007504 HflX GTPase family; Region: HflX; cd01878 707235007505 G1 box; other site 707235007506 GTP/Mg2+ binding site [chemical binding]; other site 707235007507 Switch I region; other site 707235007508 G2 box; other site 707235007509 G3 box; other site 707235007510 Switch II region; other site 707235007511 G4 box; other site 707235007512 G5 box; other site 707235007513 diaminopimelate epimerase; Region: DapF; TIGR00652 707235007514 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 707235007515 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 707235007516 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 707235007517 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 707235007518 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 707235007519 active site 707235007520 metal binding site [ion binding]; metal-binding site 707235007521 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 707235007522 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 707235007523 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 707235007524 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 707235007525 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 707235007526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235007527 FeS/SAM binding site; other site 707235007528 TRAM domain; Region: TRAM; cl01282 707235007529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235007530 FeS/SAM binding site; other site 707235007531 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 707235007532 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 707235007533 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 707235007534 hexamer interface [polypeptide binding]; other site 707235007535 Walker A motif; other site 707235007536 ATP binding site [chemical binding]; other site 707235007537 Walker B motif; other site 707235007538 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 707235007539 protein-splicing catalytic site; other site 707235007540 thioester formation/cholesterol transfer; other site 707235007541 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 707235007542 recA bacterial DNA recombination protein; Region: RecA; cl17211 707235007543 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 707235007544 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 707235007545 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 707235007546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 707235007547 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 707235007548 PE family; Region: PE; pfam00934 707235007549 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 707235007550 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 707235007551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235007552 non-specific DNA binding site [nucleotide binding]; other site 707235007553 salt bridge; other site 707235007554 sequence-specific DNA binding site [nucleotide binding]; other site 707235007555 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 707235007556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235007557 Coenzyme A binding pocket [chemical binding]; other site 707235007558 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 707235007559 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235007560 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 707235007561 Uncharacterized conserved protein [Function unknown]; Region: COG1359 707235007562 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 707235007563 classical (c) SDRs; Region: SDR_c; cd05233 707235007564 NAD(P) binding site [chemical binding]; other site 707235007565 active site 707235007566 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235007567 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235007568 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 707235007569 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 707235007570 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 707235007571 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 707235007572 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 707235007573 dimer interface [polypeptide binding]; other site 707235007574 active site 707235007575 catalytic residue [active] 707235007576 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 707235007577 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 707235007578 HsdM N-terminal domain; Region: HsdM_N; pfam12161 707235007579 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 707235007580 Methyltransferase domain; Region: Methyltransf_26; pfam13659 707235007581 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 707235007582 putative active site [active] 707235007583 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 707235007584 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 707235007585 putative active site [active] 707235007586 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 707235007587 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 707235007588 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 707235007589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 707235007590 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 707235007591 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 707235007592 folate binding site [chemical binding]; other site 707235007593 NADP+ binding site [chemical binding]; other site 707235007594 thymidylate synthase; Reviewed; Region: thyA; PRK01827 707235007595 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 707235007596 dimerization interface [polypeptide binding]; other site 707235007597 active site 707235007598 Dienelactone hydrolase family; Region: DLH; pfam01738 707235007599 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 707235007600 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 707235007601 classical (c) SDRs; Region: SDR_c; cd05233 707235007602 NAD(P) binding site [chemical binding]; other site 707235007603 active site 707235007604 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235007605 PPE family; Region: PPE; pfam00823 707235007606 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235007607 PE family; Region: PE; pfam00934 707235007608 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235007609 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235007610 PPE family; Region: PPE; pfam00823 707235007611 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 707235007612 dihydrodipicolinate reductase; Provisional; Region: PRK00048 707235007613 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 707235007614 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 707235007615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 707235007616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235007617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 707235007618 Coenzyme A binding pocket [chemical binding]; other site 707235007619 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 707235007620 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 707235007621 FMN-binding pocket [chemical binding]; other site 707235007622 flavin binding motif; other site 707235007623 phosphate binding motif [ion binding]; other site 707235007624 beta-alpha-beta structure motif; other site 707235007625 NAD binding pocket [chemical binding]; other site 707235007626 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235007627 catalytic loop [active] 707235007628 iron binding site [ion binding]; other site 707235007629 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 707235007630 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 707235007631 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 707235007632 hydrophobic ligand binding site; other site 707235007633 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 707235007634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235007635 putative DNA binding site [nucleotide binding]; other site 707235007636 putative Zn2+ binding site [ion binding]; other site 707235007637 AsnC family; Region: AsnC_trans_reg; pfam01037 707235007638 alanine dehydrogenase; Region: alaDH; TIGR00518 707235007639 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 707235007640 hexamer interface [polypeptide binding]; other site 707235007641 ligand binding site [chemical binding]; other site 707235007642 putative active site [active] 707235007643 NAD(P) binding site [chemical binding]; other site 707235007644 Nitronate monooxygenase; Region: NMO; pfam03060 707235007645 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 707235007646 FMN binding site [chemical binding]; other site 707235007647 substrate binding site [chemical binding]; other site 707235007648 putative catalytic residue [active] 707235007649 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 707235007650 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 707235007651 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 707235007652 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 707235007653 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 707235007654 oligomer interface [polypeptide binding]; other site 707235007655 RNA binding site [nucleotide binding]; other site 707235007656 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 707235007657 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 707235007658 RNase E interface [polypeptide binding]; other site 707235007659 trimer interface [polypeptide binding]; other site 707235007660 active site 707235007661 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 707235007662 putative nucleic acid binding region [nucleotide binding]; other site 707235007663 G-X-X-G motif; other site 707235007664 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 707235007665 RNA binding site [nucleotide binding]; other site 707235007666 domain interface; other site 707235007667 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 707235007668 16S/18S rRNA binding site [nucleotide binding]; other site 707235007669 S13e-L30e interaction site [polypeptide binding]; other site 707235007670 25S rRNA binding site [nucleotide binding]; other site 707235007671 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 707235007672 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 707235007673 active site 707235007674 Riboflavin kinase; Region: Flavokinase; pfam01687 707235007675 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 707235007676 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 707235007677 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 707235007678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235007679 putative DNA binding site [nucleotide binding]; other site 707235007680 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 707235007681 FeoA domain; Region: FeoA; pfam04023 707235007682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235007683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235007684 active site 707235007685 lipid-transfer protein; Provisional; Region: PRK08256 707235007686 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235007687 active site 707235007688 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 707235007689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235007690 Probable transposase; Region: OrfB_IS605; pfam01385 707235007691 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235007692 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 707235007693 catalytic residues [active] 707235007694 catalytic nucleophile [active] 707235007695 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 707235007696 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 707235007697 RNA binding site [nucleotide binding]; other site 707235007698 active site 707235007699 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 707235007700 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 707235007701 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 707235007702 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 707235007703 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 707235007704 active site 707235007705 metal binding site [ion binding]; metal-binding site 707235007706 Uncharacterized conserved protein [Function unknown]; Region: COG4717 707235007707 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 707235007708 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 707235007709 Predicted acyl esterases [General function prediction only]; Region: COG2936 707235007710 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 707235007711 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 707235007712 Uncharacterized conserved protein [Function unknown]; Region: COG5586 707235007713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 707235007714 Integrase core domain; Region: rve; pfam00665 707235007715 putative transposase OrfB; Reviewed; Region: PHA02517 707235007716 HTH-like domain; Region: HTH_21; pfam13276 707235007717 Integrase core domain; Region: rve; pfam00665 707235007718 Integrase core domain; Region: rve_3; pfam13683 707235007719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235007720 Transposase; Region: HTH_Tnp_1; cl17663 707235007721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 707235007722 Transposase; Region: DDE_Tnp_ISL3; pfam01610 707235007723 Helix-turn-helix domain; Region: HTH_28; pfam13518 707235007724 Winged helix-turn helix; Region: HTH_29; pfam13551 707235007725 Integrase core domain; Region: rve; pfam00665 707235007726 Integrase core domain; Region: rve_3; pfam13683 707235007727 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 707235007728 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 707235007729 putative transposase OrfB; Reviewed; Region: PHA02517 707235007730 HTH-like domain; Region: HTH_21; pfam13276 707235007731 Integrase core domain; Region: rve; pfam00665 707235007732 Integrase core domain; Region: rve_3; pfam13683 707235007733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235007734 Transposase; Region: HTH_Tnp_1; cl17663 707235007735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235007736 Transposase; Region: HTH_Tnp_1; cl17663 707235007737 putative transposase OrfB; Reviewed; Region: PHA02517 707235007738 HTH-like domain; Region: HTH_21; pfam13276 707235007739 Integrase core domain; Region: rve; pfam00665 707235007740 Integrase core domain; Region: rve_3; pfam13683 707235007741 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 707235007742 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 707235007743 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 707235007744 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 707235007745 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 707235007746 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 707235007747 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 707235007748 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 707235007749 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 707235007750 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 707235007751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 707235007752 Uncharacterized conserved protein [Function unknown]; Region: COG2253 707235007753 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 707235007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 707235007755 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 707235007756 putative active site [active] 707235007757 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235007758 enoyl-CoA hydratase; Provisional; Region: PRK06190 707235007759 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235007760 substrate binding site [chemical binding]; other site 707235007761 oxyanion hole (OAH) forming residues; other site 707235007762 trimer interface [polypeptide binding]; other site 707235007763 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 707235007764 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 707235007765 Walker A/P-loop; other site 707235007766 ATP binding site [chemical binding]; other site 707235007767 Q-loop/lid; other site 707235007768 ABC transporter signature motif; other site 707235007769 Walker B; other site 707235007770 D-loop; other site 707235007771 H-loop/switch region; other site 707235007772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 707235007773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 707235007774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 707235007775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235007776 dimer interface [polypeptide binding]; other site 707235007777 conserved gate region; other site 707235007778 putative PBP binding loops; other site 707235007779 ABC-ATPase subunit interface; other site 707235007780 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 707235007781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235007782 dimer interface [polypeptide binding]; other site 707235007783 conserved gate region; other site 707235007784 putative PBP binding loops; other site 707235007785 ABC-ATPase subunit interface; other site 707235007786 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 707235007787 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 707235007788 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 707235007789 DHH family; Region: DHH; pfam01368 707235007790 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 707235007791 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 707235007792 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 707235007793 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 707235007794 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 707235007795 G1 box; other site 707235007796 putative GEF interaction site [polypeptide binding]; other site 707235007797 GTP/Mg2+ binding site [chemical binding]; other site 707235007798 Switch I region; other site 707235007799 G2 box; other site 707235007800 G3 box; other site 707235007801 Switch II region; other site 707235007802 G4 box; other site 707235007803 G5 box; other site 707235007804 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 707235007805 Translation-initiation factor 2; Region: IF-2; pfam11987 707235007806 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 707235007807 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 707235007808 putative RNA binding cleft [nucleotide binding]; other site 707235007809 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 707235007810 NusA N-terminal domain; Region: NusA_N; pfam08529 707235007811 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 707235007812 RNA binding site [nucleotide binding]; other site 707235007813 homodimer interface [polypeptide binding]; other site 707235007814 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 707235007815 G-X-X-G motif; other site 707235007816 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 707235007817 G-X-X-G motif; other site 707235007818 ribosome maturation protein RimP; Reviewed; Region: PRK00092 707235007819 Sm and related proteins; Region: Sm_like; cl00259 707235007820 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 707235007821 putative oligomer interface [polypeptide binding]; other site 707235007822 putative RNA binding site [nucleotide binding]; other site 707235007823 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 707235007824 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 707235007825 dinuclear metal binding motif [ion binding]; other site 707235007826 prolyl-tRNA synthetase; Provisional; Region: PRK09194 707235007827 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 707235007828 dimer interface [polypeptide binding]; other site 707235007829 motif 1; other site 707235007830 active site 707235007831 motif 2; other site 707235007832 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 707235007833 putative deacylase active site [active] 707235007834 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707235007835 active site 707235007836 motif 3; other site 707235007837 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 707235007838 anticodon binding site; other site 707235007839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235007840 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235007841 putative substrate translocation pore; other site 707235007842 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 707235007843 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 707235007844 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 707235007845 homodimer interface [polypeptide binding]; other site 707235007846 active site 707235007847 SAM binding site [chemical binding]; other site 707235007848 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 707235007849 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 707235007850 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 707235007851 catalytic triad [active] 707235007852 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 707235007853 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 707235007854 homodimer interface [polypeptide binding]; other site 707235007855 Walker A motif; other site 707235007856 ATP binding site [chemical binding]; other site 707235007857 hydroxycobalamin binding site [chemical binding]; other site 707235007858 Walker B motif; other site 707235007859 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 707235007860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235007861 Walker A motif; other site 707235007862 ATP binding site [chemical binding]; other site 707235007863 Walker B motif; other site 707235007864 arginine finger; other site 707235007865 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 707235007866 metal ion-dependent adhesion site (MIDAS); other site 707235007867 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 707235007868 malate:quinone oxidoreductase; Validated; Region: PRK05257 707235007869 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 707235007870 PE family; Region: PE; pfam00934 707235007871 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 707235007872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235007873 mycothione reductase; Reviewed; Region: PRK07846 707235007874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235007875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235007876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707235007877 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 707235007878 short chain dehydrogenase; Provisional; Region: PRK06057 707235007879 classical (c) SDRs; Region: SDR_c; cd05233 707235007880 NAD(P) binding site [chemical binding]; other site 707235007881 active site 707235007882 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 707235007883 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 707235007884 NAD(P) binding site [chemical binding]; other site 707235007885 catalytic residues [active] 707235007886 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 707235007887 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 707235007888 catalytic triad [active] 707235007889 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 707235007890 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 707235007891 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 707235007892 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 707235007893 active site 707235007894 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 707235007895 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 707235007896 putative active site [active] 707235007897 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 707235007898 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 707235007899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 707235007900 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 707235007901 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 707235007902 Predicted acetyltransferase [General function prediction only]; Region: COG3393 707235007903 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 707235007904 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 707235007905 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 707235007906 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 707235007907 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 707235007908 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 707235007909 active site 707235007910 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 707235007911 protein binding site [polypeptide binding]; other site 707235007912 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 707235007913 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 707235007914 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 707235007915 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 707235007916 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235007917 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235007918 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 707235007919 Fasciclin domain; Region: Fasciclin; pfam02469 707235007920 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 707235007921 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 707235007922 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 707235007923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235007924 catalytic residues [active] 707235007925 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 707235007926 Fasciclin domain; Region: Fasciclin; pfam02469 707235007927 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 707235007928 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 707235007929 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 707235007930 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235007931 catalytic residues [active] 707235007932 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 707235007933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235007934 FeS/SAM binding site; other site 707235007935 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 707235007936 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 707235007937 ribosome recycling factor; Reviewed; Region: frr; PRK00083 707235007938 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 707235007939 hinge region; other site 707235007940 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 707235007941 putative nucleotide binding site [chemical binding]; other site 707235007942 uridine monophosphate binding site [chemical binding]; other site 707235007943 homohexameric interface [polypeptide binding]; other site 707235007944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235007945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235007946 DNA binding site [nucleotide binding] 707235007947 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 707235007948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235007949 Probable transposase; Region: OrfB_IS605; pfam01385 707235007950 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235007951 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 707235007952 catalytic residues [active] 707235007953 catalytic nucleophile [active] 707235007954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 707235007955 MarR family; Region: MarR; pfam01047 707235007956 amidase; Provisional; Region: PRK07869 707235007957 Amidase; Region: Amidase; pfam01425 707235007958 elongation factor Ts; Provisional; Region: tsf; PRK09377 707235007959 UBA/TS-N domain; Region: UBA; pfam00627 707235007960 Elongation factor TS; Region: EF_TS; pfam00889 707235007961 Elongation factor TS; Region: EF_TS; pfam00889 707235007962 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 707235007963 rRNA interaction site [nucleotide binding]; other site 707235007964 S8 interaction site; other site 707235007965 putative laminin-1 binding site; other site 707235007966 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 707235007967 Peptidase family M23; Region: Peptidase_M23; pfam01551 707235007968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235007969 PPE family; Region: PPE; pfam00823 707235007970 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235007971 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 707235007972 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235007973 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 707235007974 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235007975 active site 707235007976 DNA binding site [nucleotide binding] 707235007977 Int/Topo IB signature motif; other site 707235007978 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 707235007979 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 707235007980 FAD binding pocket [chemical binding]; other site 707235007981 FAD binding motif [chemical binding]; other site 707235007982 phosphate binding motif [ion binding]; other site 707235007983 NAD binding pocket [chemical binding]; other site 707235007984 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 707235007985 DNA protecting protein DprA; Region: dprA; TIGR00732 707235007986 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 707235007987 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 707235007988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235007989 Walker A motif; other site 707235007990 ATP binding site [chemical binding]; other site 707235007991 Walker B motif; other site 707235007992 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 707235007993 hypothetical protein; Reviewed; Region: PRK12497 707235007994 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 707235007995 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 707235007996 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 707235007997 putative molybdopterin cofactor binding site [chemical binding]; other site 707235007998 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 707235007999 putative molybdopterin cofactor binding site; other site 707235008000 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 707235008001 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 707235008002 RNA/DNA hybrid binding site [nucleotide binding]; other site 707235008003 active site 707235008004 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 707235008005 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 707235008006 Catalytic site [active] 707235008007 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 707235008008 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 707235008009 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 707235008010 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 707235008011 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 707235008012 RimM N-terminal domain; Region: RimM; pfam01782 707235008013 hypothetical protein; Provisional; Region: PRK02821 707235008014 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 707235008015 G-X-X-G motif; other site 707235008016 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 707235008017 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 707235008018 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 707235008019 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 707235008020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008022 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 707235008023 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 707235008024 active site 707235008025 putative substrate binding pocket [chemical binding]; other site 707235008026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 707235008027 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235008028 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235008029 active site 707235008030 ATP binding site [chemical binding]; other site 707235008031 substrate binding site [chemical binding]; other site 707235008032 activation loop (A-loop); other site 707235008033 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 707235008034 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 707235008035 active site 707235008036 signal recognition particle protein; Provisional; Region: PRK10867 707235008037 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 707235008038 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 707235008039 P loop; other site 707235008040 GTP binding site [chemical binding]; other site 707235008041 Signal peptide binding domain; Region: SRP_SPB; pfam02978 707235008042 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 707235008043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 707235008044 ATP binding site [chemical binding]; other site 707235008045 putative Mg++ binding site [ion binding]; other site 707235008046 PII uridylyl-transferase; Provisional; Region: PRK03381 707235008047 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 707235008048 metal binding triad; other site 707235008049 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 707235008050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 707235008051 Zn2+ binding site [ion binding]; other site 707235008052 Mg2+ binding site [ion binding]; other site 707235008053 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 707235008054 Nitrogen regulatory protein P-II; Region: P-II; smart00938 707235008055 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 707235008056 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 707235008057 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 707235008058 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 707235008059 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 707235008060 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 707235008061 Walker A/P-loop; other site 707235008062 ATP binding site [chemical binding]; other site 707235008063 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 707235008064 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 707235008065 ABC transporter signature motif; other site 707235008066 Walker B; other site 707235008067 D-loop; other site 707235008068 H-loop/switch region; other site 707235008069 acylphosphatase; Provisional; Region: PRK14422 707235008070 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 707235008071 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 707235008072 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 707235008073 DNA binding site [nucleotide binding] 707235008074 catalytic residue [active] 707235008075 H2TH interface [polypeptide binding]; other site 707235008076 putative catalytic residues [active] 707235008077 turnover-facilitating residue; other site 707235008078 intercalation triad [nucleotide binding]; other site 707235008079 8OG recognition residue [nucleotide binding]; other site 707235008080 putative reading head residues; other site 707235008081 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 707235008082 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 707235008083 ribonuclease III; Reviewed; Region: rnc; PRK00102 707235008084 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 707235008085 dimerization interface [polypeptide binding]; other site 707235008086 active site 707235008087 metal binding site [ion binding]; metal-binding site 707235008088 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 707235008089 dsRNA binding site [nucleotide binding]; other site 707235008090 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 707235008091 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 707235008092 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 707235008093 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 707235008094 acyl-CoA synthetase; Validated; Region: PRK05850 707235008095 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235008096 acyl-activating enzyme (AAE) consensus motif; other site 707235008097 active site 707235008098 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235008099 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235008100 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008101 active site 707235008102 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 707235008103 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235008104 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 707235008105 NADP binding site [chemical binding]; other site 707235008106 KR domain; Region: KR; pfam08659 707235008107 active site 707235008108 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 707235008111 active site 707235008112 Acyl transferase domain; Region: Acyl_transf_1; cl08282 707235008113 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 707235008114 KR domain; Region: KR; pfam08659 707235008115 NADP binding site [chemical binding]; other site 707235008116 active site 707235008117 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008118 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235008119 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008120 active site 707235008121 Acyl transferase domain; Region: Acyl_transf_1; cl08282 707235008122 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235008123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235008124 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235008125 Enoylreductase; Region: PKS_ER; smart00829 707235008126 NAD(P) binding site [chemical binding]; other site 707235008127 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235008128 KR domain; Region: KR; pfam08659 707235008129 putative NADP binding site [chemical binding]; other site 707235008130 active site 707235008131 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008132 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235008133 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008134 active site 707235008135 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235008136 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235008137 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235008138 KR domain; Region: KR; pfam08659 707235008139 putative NADP binding site [chemical binding]; other site 707235008140 active site 707235008141 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008142 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235008143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008144 active site 707235008145 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235008146 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 707235008147 Condensation domain; Region: Condensation; pfam00668 707235008148 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 707235008149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235008150 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 707235008151 Walker A/P-loop; other site 707235008152 ATP binding site [chemical binding]; other site 707235008153 Q-loop/lid; other site 707235008154 ABC transporter signature motif; other site 707235008155 Walker B; other site 707235008156 D-loop; other site 707235008157 H-loop/switch region; other site 707235008158 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 707235008159 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 707235008160 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 707235008161 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 707235008162 acyltransferase PapA5; Provisional; Region: PRK09294 707235008163 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235008164 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008165 active site 707235008166 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 707235008167 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235008168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235008169 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235008170 Enoylreductase; Region: PKS_ER; smart00829 707235008171 NAD(P) binding site [chemical binding]; other site 707235008172 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235008173 KR domain; Region: KR; pfam08659 707235008174 putative NADP binding site [chemical binding]; other site 707235008175 active site 707235008176 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008177 acyl-CoA synthetase; Validated; Region: PRK05850 707235008178 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235008179 acyl-activating enzyme (AAE) consensus motif; other site 707235008180 active site 707235008181 MMPL family; Region: MMPL; pfam03176 707235008182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 707235008183 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 707235008184 Integrase core domain; Region: rve; pfam00665 707235008185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 707235008186 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 707235008187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235008188 ATP binding site [chemical binding]; other site 707235008189 Walker A motif; other site 707235008190 Walker B motif; other site 707235008191 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 707235008192 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235008193 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235008194 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235008195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235008196 Enoylreductase; Region: PKS_ER; smart00829 707235008197 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235008198 NAD(P) binding site [chemical binding]; other site 707235008199 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 707235008200 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 707235008201 putative NADP binding site [chemical binding]; other site 707235008202 active site 707235008203 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008204 Erythronolide synthase docking; Region: Docking; pfam08990 707235008205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235008206 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 707235008207 active site 707235008208 acyl-CoA synthetase; Validated; Region: PRK06060 707235008209 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 707235008210 dimer interface [polypeptide binding]; other site 707235008211 acyl-activating enzyme (AAE) consensus motif; other site 707235008212 putative active site [active] 707235008213 putative AMP binding site [chemical binding]; other site 707235008214 putative CoA binding site [chemical binding]; other site 707235008215 chemical substrate binding site [chemical binding]; other site 707235008216 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235008217 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 707235008218 acyl-CoA synthetase; Validated; Region: PRK05850 707235008219 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235008220 acyl-activating enzyme (AAE) consensus motif; other site 707235008221 active site 707235008222 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 707235008223 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235008224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008225 S-adenosylmethionine binding site [chemical binding]; other site 707235008226 Uncharacterized conserved protein [Function unknown]; Region: COG3268 707235008227 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235008228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008229 S-adenosylmethionine binding site [chemical binding]; other site 707235008230 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 707235008231 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 707235008232 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 707235008233 metal-binding site 707235008234 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 707235008235 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 707235008236 active site 707235008237 TDP-binding site; other site 707235008238 acceptor substrate-binding pocket; other site 707235008239 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 707235008240 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 707235008241 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 707235008242 Predicted permease; Region: DUF318; pfam03773 707235008243 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 707235008244 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 707235008245 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 707235008246 putative active site [active] 707235008247 putative substrate binding site [chemical binding]; other site 707235008248 putative cosubstrate binding site; other site 707235008249 catalytic site [active] 707235008250 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 707235008251 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 707235008252 active site 707235008253 (T/H)XGH motif; other site 707235008254 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 707235008255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008256 S-adenosylmethionine binding site [chemical binding]; other site 707235008257 pyruvate carboxylase; Reviewed; Region: PRK12999 707235008258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235008259 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707235008260 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 707235008261 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 707235008262 active site 707235008263 catalytic residues [active] 707235008264 metal binding site [ion binding]; metal-binding site 707235008265 homodimer binding site [polypeptide binding]; other site 707235008266 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707235008267 carboxyltransferase (CT) interaction site; other site 707235008268 biotinylation site [posttranslational modification]; other site 707235008269 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 707235008270 putative active site [active] 707235008271 redox center [active] 707235008272 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 707235008273 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 707235008274 catalytic residues [active] 707235008275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 707235008276 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235008277 substrate binding pocket [chemical binding]; other site 707235008278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 707235008279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 707235008280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 707235008281 active site 707235008282 catalytic tetrad [active] 707235008283 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 707235008284 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 707235008285 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 707235008286 generic binding surface II; other site 707235008287 ssDNA binding site; other site 707235008288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235008289 ATP binding site [chemical binding]; other site 707235008290 putative Mg++ binding site [ion binding]; other site 707235008291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235008292 nucleotide binding region [chemical binding]; other site 707235008293 ATP-binding site [chemical binding]; other site 707235008294 potential frameshift: common BLAST hit: gi|340627964|ref|YP_004746416.1| dak2 domain-containing protein 707235008295 DAK2 domain; Region: Dak2; cl03685 707235008296 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 707235008297 DAK2 domain; Region: Dak2; cl03685 707235008298 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 707235008299 ligand binding site [chemical binding]; other site 707235008300 active site 707235008301 UGI interface [polypeptide binding]; other site 707235008302 catalytic site [active] 707235008303 thiamine monophosphate kinase; Provisional; Region: PRK05731 707235008304 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 707235008305 ATP binding site [chemical binding]; other site 707235008306 dimerization interface [polypeptide binding]; other site 707235008307 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 707235008308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235008309 Probable transposase; Region: OrfB_IS605; pfam01385 707235008310 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235008311 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 707235008312 catalytic residues [active] 707235008313 catalytic nucleophile [active] 707235008314 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 707235008315 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 707235008316 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 707235008317 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 707235008318 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 707235008319 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 707235008320 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 707235008321 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 707235008322 polyphosphate kinase; Provisional; Region: PRK05443 707235008323 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 707235008324 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 707235008325 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 707235008326 putative domain interface [polypeptide binding]; other site 707235008327 putative active site [active] 707235008328 catalytic site [active] 707235008329 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 707235008330 putative domain interface [polypeptide binding]; other site 707235008331 putative active site [active] 707235008332 catalytic site [active] 707235008333 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 707235008334 active site 707235008335 Ap6A binding site [chemical binding]; other site 707235008336 nudix motif; other site 707235008337 metal binding site [ion binding]; metal-binding site 707235008338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235008339 catalytic core [active] 707235008340 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 707235008341 IHF - DNA interface [nucleotide binding]; other site 707235008342 IHF dimer interface [polypeptide binding]; other site 707235008343 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 707235008344 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 707235008345 substrate binding site [chemical binding]; other site 707235008346 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 707235008347 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 707235008348 substrate binding site [chemical binding]; other site 707235008349 ligand binding site [chemical binding]; other site 707235008350 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 707235008351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 707235008352 Bacterial transcriptional regulator; Region: IclR; pfam01614 707235008353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008354 S-adenosylmethionine binding site [chemical binding]; other site 707235008355 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 707235008356 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 707235008357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 707235008358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235008359 active site 707235008360 HIGH motif; other site 707235008361 nucleotide binding site [chemical binding]; other site 707235008362 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 707235008363 active site 707235008364 KMSKS motif; other site 707235008365 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 707235008366 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 707235008367 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 707235008368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235008369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707235008370 putative substrate translocation pore; other site 707235008371 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 707235008372 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 707235008373 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 707235008374 ligand binding site [chemical binding]; other site 707235008375 NAD binding site [chemical binding]; other site 707235008376 dimerization interface [polypeptide binding]; other site 707235008377 catalytic site [active] 707235008378 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 707235008379 putative L-serine binding site [chemical binding]; other site 707235008380 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 707235008381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235008382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 707235008383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 707235008384 phosphorylation site [posttranslational modification] 707235008385 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 707235008386 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 707235008387 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 707235008388 ketol-acid reductoisomerase; Provisional; Region: PRK05479 707235008389 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 707235008390 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 707235008391 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 707235008392 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 707235008393 putative valine binding site [chemical binding]; other site 707235008394 dimer interface [polypeptide binding]; other site 707235008395 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 707235008396 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 707235008397 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 707235008398 PYR/PP interface [polypeptide binding]; other site 707235008399 dimer interface [polypeptide binding]; other site 707235008400 TPP binding site [chemical binding]; other site 707235008401 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 707235008402 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 707235008403 TPP-binding site [chemical binding]; other site 707235008404 dimer interface [polypeptide binding]; other site 707235008405 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 707235008406 Predicted membrane protein [Function unknown]; Region: COG2259 707235008407 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 707235008408 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 707235008409 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 707235008410 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 707235008411 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 707235008412 GatB domain; Region: GatB_Yqey; smart00845 707235008413 6-phosphofructokinase; Provisional; Region: PRK03202 707235008414 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 707235008415 active site 707235008416 ADP/pyrophosphate binding site [chemical binding]; other site 707235008417 dimerization interface [polypeptide binding]; other site 707235008418 allosteric effector site; other site 707235008419 fructose-1,6-bisphosphate binding site; other site 707235008420 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 707235008421 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 707235008422 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 707235008423 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 707235008424 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 707235008425 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 707235008426 nucleotide binding pocket [chemical binding]; other site 707235008427 K-X-D-G motif; other site 707235008428 catalytic site [active] 707235008429 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 707235008430 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 707235008431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 707235008432 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 707235008433 Dimer interface [polypeptide binding]; other site 707235008434 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 707235008435 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235008436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235008437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008438 PPE family; Region: PPE; pfam00823 707235008439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235008440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008441 PPE family; Region: PPE; pfam00823 707235008442 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235008443 MULE transposase domain; Region: MULE; pfam10551 707235008444 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 707235008445 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 707235008446 Ligand Binding Site [chemical binding]; other site 707235008447 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 707235008448 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 707235008449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235008450 catalytic residue [active] 707235008451 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235008452 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235008453 putative acyl-acceptor binding pocket; other site 707235008454 Putative hemolysin [General function prediction only]; Region: COG3176 707235008455 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 707235008456 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 707235008457 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 707235008458 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 707235008459 Ligand binding site [chemical binding]; other site 707235008460 Electron transfer flavoprotein domain; Region: ETF; pfam01012 707235008461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008462 S-adenosylmethionine binding site [chemical binding]; other site 707235008463 Uncharacterized conserved protein [Function unknown]; Region: COG1543 707235008464 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 707235008465 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 707235008466 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 707235008467 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 707235008468 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 707235008469 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 707235008470 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 707235008471 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 707235008472 trimer interface [polypeptide binding]; other site 707235008473 active site 707235008474 substrate binding site [chemical binding]; other site 707235008475 CoA binding site [chemical binding]; other site 707235008476 FOG: WD40-like repeat [Function unknown]; Region: COG1520 707235008477 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 707235008478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008479 S-adenosylmethionine binding site [chemical binding]; other site 707235008480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235008481 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 707235008482 substrate binding site [chemical binding]; other site 707235008483 oxyanion hole (OAH) forming residues; other site 707235008484 trimer interface [polypeptide binding]; other site 707235008485 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 707235008486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235008487 Walker A/P-loop; other site 707235008488 ATP binding site [chemical binding]; other site 707235008489 Q-loop/lid; other site 707235008490 ABC transporter signature motif; other site 707235008491 Walker B; other site 707235008492 D-loop; other site 707235008493 H-loop/switch region; other site 707235008494 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 707235008495 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 707235008496 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 707235008497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235008498 motif II; other site 707235008499 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 707235008500 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 707235008501 D-pathway; other site 707235008502 Putative ubiquinol binding site [chemical binding]; other site 707235008503 Low-spin heme (heme b) binding site [chemical binding]; other site 707235008504 Putative water exit pathway; other site 707235008505 Binuclear center (heme o3/CuB) [ion binding]; other site 707235008506 K-pathway; other site 707235008507 Putative proton exit pathway; other site 707235008508 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 707235008509 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 707235008510 siderophore binding site; other site 707235008511 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 707235008512 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 707235008513 putative NAD(P) binding site [chemical binding]; other site 707235008514 putative substrate binding site [chemical binding]; other site 707235008515 catalytic Zn binding site [ion binding]; other site 707235008516 structural Zn binding site [ion binding]; other site 707235008517 dimer interface [polypeptide binding]; other site 707235008518 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 707235008519 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 707235008520 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 707235008521 dimer interface [polypeptide binding]; other site 707235008522 putative radical transfer pathway; other site 707235008523 diiron center [ion binding]; other site 707235008524 tyrosyl radical; other site 707235008525 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235008526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235008527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008529 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 707235008530 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 707235008531 Class I ribonucleotide reductase; Region: RNR_I; cd01679 707235008532 active site 707235008533 dimer interface [polypeptide binding]; other site 707235008534 catalytic residues [active] 707235008535 effector binding site; other site 707235008536 R2 peptide binding site; other site 707235008537 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 707235008538 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 707235008539 catalytic residues [active] 707235008540 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 707235008541 Predicted flavoprotein [General function prediction only]; Region: COG0431 707235008542 DNA polymerase IV; Validated; Region: PRK03352 707235008543 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 707235008544 active site 707235008545 DNA binding site [nucleotide binding] 707235008546 short chain dehydrogenase; Provisional; Region: PRK07832 707235008547 classical (c) SDRs; Region: SDR_c; cd05233 707235008548 NAD(P) binding site [chemical binding]; other site 707235008549 active site 707235008550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008552 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235008553 Cytochrome P450; Region: p450; cl12078 707235008554 Transcriptional regulators [Transcription]; Region: FadR; COG2186 707235008555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235008556 DNA-binding site [nucleotide binding]; DNA binding site 707235008557 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 707235008558 Transcriptional regulators [Transcription]; Region: FadR; COG2186 707235008559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 707235008560 DNA-binding site [nucleotide binding]; DNA binding site 707235008561 FCD domain; Region: FCD; pfam07729 707235008562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235008563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235008564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235008565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235008566 active site 707235008567 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 707235008568 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 707235008569 active site 707235008570 DNA binding site [nucleotide binding] 707235008571 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 707235008572 DNA binding site [nucleotide binding] 707235008573 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 707235008574 Carbon starvation protein CstA; Region: CstA; pfam02554 707235008575 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 707235008576 Predicted membrane protein [Function unknown]; Region: COG2259 707235008577 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 707235008578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 707235008579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008580 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235008581 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 707235008582 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 707235008583 active site 707235008584 substrate binding site [chemical binding]; other site 707235008585 metal binding site [ion binding]; metal-binding site 707235008586 camphor resistance protein CrcB; Provisional; Region: PRK14216 707235008587 camphor resistance protein CrcB; Provisional; Region: PRK14228 707235008588 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 707235008589 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 707235008590 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 707235008591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235008592 Uncharacterized conserved protein [Function unknown]; Region: COG3189 707235008593 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235008594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235008595 active site 707235008596 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 707235008597 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 707235008598 putative hydrophobic ligand binding site [chemical binding]; other site 707235008599 protein interface [polypeptide binding]; other site 707235008600 gate; other site 707235008601 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 707235008602 Sulfatase; Region: Sulfatase; pfam00884 707235008603 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 707235008604 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235008605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707235008606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707235008607 active site 707235008608 ATP binding site [chemical binding]; other site 707235008609 substrate binding site [chemical binding]; other site 707235008610 activation loop (A-loop); other site 707235008611 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 707235008612 AAA ATPase domain; Region: AAA_16; pfam13191 707235008613 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 707235008614 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 707235008615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 707235008616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 707235008617 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235008618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235008619 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 707235008620 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235008621 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235008622 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235008623 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235008624 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 707235008625 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 707235008626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235008627 acyl-activating enzyme (AAE) consensus motif; other site 707235008628 AMP binding site [chemical binding]; other site 707235008629 active site 707235008630 CoA binding site [chemical binding]; other site 707235008631 SPFH domain / Band 7 family; Region: Band_7; pfam01145 707235008632 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 707235008633 Patatin-like phospholipase; Region: Patatin; pfam01734 707235008634 Protein of unknown function (DUF808); Region: DUF808; cl01002 707235008635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235008636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235008637 active site 707235008638 Predicted transcriptional regulators [Transcription]; Region: COG1733 707235008639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235008640 dimerization interface [polypeptide binding]; other site 707235008641 putative DNA binding site [nucleotide binding]; other site 707235008642 putative Zn2+ binding site [ion binding]; other site 707235008643 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 707235008644 PE family; Region: PE; pfam00934 707235008645 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235008646 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 707235008647 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235008648 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 707235008649 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 707235008650 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 707235008651 SmpB-tmRNA interface; other site 707235008652 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 707235008653 FtsX-like permease family; Region: FtsX; pfam02687 707235008654 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 707235008655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707235008656 Walker A/P-loop; other site 707235008657 ATP binding site [chemical binding]; other site 707235008658 Q-loop/lid; other site 707235008659 ABC transporter signature motif; other site 707235008660 Walker B; other site 707235008661 D-loop; other site 707235008662 H-loop/switch region; other site 707235008663 Mechanosensitive ion channel; Region: MS_channel; pfam00924 707235008664 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 707235008665 peptide chain release factor 2; Validated; Region: prfB; PRK00578 707235008666 This domain is found in peptide chain release factors; Region: PCRF; smart00937 707235008667 RF-1 domain; Region: RF-1; pfam00472 707235008668 ferredoxin-NADP+ reductase; Region: PLN02852 707235008669 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235008670 FAD binding domain; Region: FAD_binding_4; pfam01565 707235008671 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 707235008672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235008673 FeS/SAM binding site; other site 707235008674 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 707235008675 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 707235008676 aromatic arch; other site 707235008677 DCoH dimer interaction site [polypeptide binding]; other site 707235008678 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 707235008679 DCoH tetramer interaction site [polypeptide binding]; other site 707235008680 substrate binding site [chemical binding]; other site 707235008681 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 707235008682 trimer interface [polypeptide binding]; other site 707235008683 dimer interface [polypeptide binding]; other site 707235008684 putative active site [active] 707235008685 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 707235008686 MoaE interaction surface [polypeptide binding]; other site 707235008687 MoeB interaction surface [polypeptide binding]; other site 707235008688 thiocarboxylated glycine; other site 707235008689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235008690 Transposase; Region: HTH_Tnp_1; cl17663 707235008691 putative transposase OrfB; Reviewed; Region: PHA02517 707235008692 HTH-like domain; Region: HTH_21; pfam13276 707235008693 Integrase core domain; Region: rve; pfam00665 707235008694 Integrase core domain; Region: rve_3; pfam13683 707235008695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 707235008696 nucleoside/Zn binding site; other site 707235008697 dimer interface [polypeptide binding]; other site 707235008698 catalytic motif [active] 707235008699 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235008700 MULE transposase domain; Region: MULE; pfam10551 707235008701 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 707235008702 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 707235008703 ATP binding site [chemical binding]; other site 707235008704 substrate interface [chemical binding]; other site 707235008705 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 707235008706 active site residue [active] 707235008707 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 707235008708 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 707235008709 active site residue [active] 707235008710 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 707235008711 active site residue [active] 707235008712 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 707235008713 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 707235008714 MoaE homodimer interface [polypeptide binding]; other site 707235008715 MoaD interaction [polypeptide binding]; other site 707235008716 active site residues [active] 707235008717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235008718 S-adenosylmethionine binding site [chemical binding]; other site 707235008719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235008720 Cytochrome P450; Region: p450; cl12078 707235008721 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 707235008722 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 707235008723 DNA binding site [nucleotide binding] 707235008724 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008725 PPE family; Region: PPE; pfam00823 707235008726 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 707235008727 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 707235008728 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235008729 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235008730 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 707235008731 dimer interface [polypeptide binding]; other site 707235008732 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 707235008733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 707235008734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 707235008735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 707235008736 Histidine kinase; Region: HisKA_3; pfam07730 707235008737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235008738 ATP binding site [chemical binding]; other site 707235008739 Mg2+ binding site [ion binding]; other site 707235008740 G-X-G motif; other site 707235008741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 707235008742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235008743 active site 707235008744 phosphorylation site [posttranslational modification] 707235008745 intermolecular recognition site; other site 707235008746 dimerization interface [polypeptide binding]; other site 707235008747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 707235008748 DNA binding residues [nucleotide binding] 707235008749 dimerization interface [polypeptide binding]; other site 707235008750 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 707235008751 Ligand Binding Site [chemical binding]; other site 707235008752 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008753 PPE family; Region: PPE; pfam00823 707235008754 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008755 PPE family; Region: PPE; pfam00823 707235008756 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235008757 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 707235008758 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 707235008759 active site 707235008760 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 707235008761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235008762 FeS/SAM binding site; other site 707235008763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235008764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235008765 active site 707235008766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235008767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235008768 active site 707235008769 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 707235008770 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 707235008771 NAD(P) binding site [chemical binding]; other site 707235008772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235008773 active site 707235008774 phosphorylation site [posttranslational modification] 707235008775 intermolecular recognition site; other site 707235008776 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008777 PPE family; Region: PPE; pfam00823 707235008778 NADH dehydrogenase subunit A; Validated; Region: PRK07928 707235008779 NADH dehydrogenase subunit B; Validated; Region: PRK06411 707235008780 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 707235008781 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 707235008782 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 707235008783 NADH dehydrogenase subunit D; Validated; Region: PRK06075 707235008784 NADH dehydrogenase subunit E; Validated; Region: PRK07539 707235008785 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 707235008786 putative dimer interface [polypeptide binding]; other site 707235008787 [2Fe-2S] cluster binding site [ion binding]; other site 707235008788 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 707235008789 SLBB domain; Region: SLBB; pfam10531 707235008790 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 707235008791 NADH dehydrogenase subunit G; Validated; Region: PRK07860 707235008792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235008793 catalytic loop [active] 707235008794 iron binding site [ion binding]; other site 707235008795 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 707235008796 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 707235008797 [4Fe-4S] binding site [ion binding]; other site 707235008798 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 707235008799 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 707235008800 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 707235008801 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 707235008802 4Fe-4S binding domain; Region: Fer4; pfam00037 707235008803 4Fe-4S binding domain; Region: Fer4; pfam00037 707235008804 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 707235008805 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 707235008806 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 707235008807 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 707235008808 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 707235008809 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 707235008810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 707235008811 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 707235008812 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 707235008813 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235008814 PPE family; Region: PPE; pfam00823 707235008815 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 707235008816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008817 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 707235008818 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 707235008819 [2Fe-2S] cluster binding site [ion binding]; other site 707235008820 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 707235008821 putative alpha subunit interface [polypeptide binding]; other site 707235008822 putative active site [active] 707235008823 putative substrate binding site [chemical binding]; other site 707235008824 Fe binding site [ion binding]; other site 707235008825 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 707235008826 Protein of unknown function DUF58; Region: DUF58; pfam01882 707235008827 MoxR-like ATPases [General function prediction only]; Region: COG0714 707235008828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235008829 Walker A motif; other site 707235008830 ATP binding site [chemical binding]; other site 707235008831 Walker B motif; other site 707235008832 arginine finger; other site 707235008833 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 707235008834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008836 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 707235008837 putative active site [active] 707235008838 putative substrate binding site [chemical binding]; other site 707235008839 ATP binding site [chemical binding]; other site 707235008840 Phosphotransferase enzyme family; Region: APH; pfam01636 707235008841 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 707235008842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235008843 hydroxyglutarate oxidase; Provisional; Region: PRK11728 707235008844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235008845 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235008846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008848 short chain dehydrogenase; Validated; Region: PRK08264 707235008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235008850 NAD(P) binding site [chemical binding]; other site 707235008851 active site 707235008852 amidase; Provisional; Region: PRK06170 707235008853 Amidase; Region: Amidase; pfam01425 707235008854 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235008855 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235008856 TAP-like protein; Region: Abhydrolase_4; pfam08386 707235008857 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235008858 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 707235008859 AAA domain; Region: AAA_14; pfam13173 707235008860 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 707235008861 putative active site [active] 707235008862 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235008863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 707235008864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 707235008865 non-specific DNA binding site [nucleotide binding]; other site 707235008866 salt bridge; other site 707235008867 sequence-specific DNA binding site [nucleotide binding]; other site 707235008868 RES domain; Region: RES; pfam08808 707235008869 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 707235008870 Helix-turn-helix domain; Region: HTH_38; pfam13936 707235008871 Integrase core domain; Region: rve; pfam00665 707235008872 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 707235008873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235008874 hypothetical protein; Validated; Region: PRK00068 707235008875 Uncharacterized conserved protein [Function unknown]; Region: COG1615 707235008876 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 707235008877 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 707235008878 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 707235008879 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 707235008880 Uncharacterized conserved protein [Function unknown]; Region: COG5282 707235008881 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 707235008882 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 707235008883 ABC1 family; Region: ABC1; pfam03109 707235008884 Phosphotransferase enzyme family; Region: APH; pfam01636 707235008885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 707235008886 active site 707235008887 ATP binding site [chemical binding]; other site 707235008888 Transcription factor WhiB; Region: Whib; pfam02467 707235008889 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 707235008890 Part of AAA domain; Region: AAA_19; pfam13245 707235008891 Family description; Region: UvrD_C_2; pfam13538 707235008892 HRDC domain; Region: HRDC; pfam00570 707235008893 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 707235008894 catalytic residues [active] 707235008895 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 707235008896 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 707235008897 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 707235008898 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 707235008899 putative NADH binding site [chemical binding]; other site 707235008900 putative active site [active] 707235008901 nudix motif; other site 707235008902 putative metal binding site [ion binding]; other site 707235008903 Ion channel; Region: Ion_trans_2; pfam07885 707235008904 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 707235008905 TrkA-N domain; Region: TrkA_N; pfam02254 707235008906 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 707235008907 Part of AAA domain; Region: AAA_19; pfam13245 707235008908 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 707235008909 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 707235008910 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 707235008911 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 707235008912 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 707235008913 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 707235008914 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 707235008915 active site 707235008916 DNA binding site [nucleotide binding] 707235008917 TIGR02569 family protein; Region: TIGR02569_actnb 707235008918 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 707235008919 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 707235008920 ATP binding site [chemical binding]; other site 707235008921 substrate interface [chemical binding]; other site 707235008922 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 707235008923 active site residue [active] 707235008924 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 707235008925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235008926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235008927 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 707235008928 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 707235008929 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 707235008930 DEAD-like helicases superfamily; Region: DEXDc; smart00487 707235008931 ATP binding site [chemical binding]; other site 707235008932 Mg++ binding site [ion binding]; other site 707235008933 motif III; other site 707235008934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235008935 nucleotide binding region [chemical binding]; other site 707235008936 ATP-binding site [chemical binding]; other site 707235008937 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 707235008938 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235008939 P-loop; other site 707235008940 Magnesium ion binding site [ion binding]; other site 707235008941 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235008942 Magnesium ion binding site [ion binding]; other site 707235008943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235008944 catalytic core [active] 707235008945 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 707235008946 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 707235008947 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 707235008948 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 707235008949 Transcription factor WhiB; Region: Whib; pfam02467 707235008950 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 707235008951 PAS domain S-box; Region: sensory_box; TIGR00229 707235008952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 707235008953 Histidine kinase; Region: HisKA_2; pfam07568 707235008954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235008955 ATP binding site [chemical binding]; other site 707235008956 Mg2+ binding site [ion binding]; other site 707235008957 G-X-G motif; other site 707235008958 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707235008959 carboxyltransferase (CT) interaction site; other site 707235008960 biotinylation site [posttranslational modification]; other site 707235008961 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 707235008962 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 707235008963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235008964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235008965 DNA binding residues [nucleotide binding] 707235008966 short chain dehydrogenase; Provisional; Region: PRK08278 707235008967 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 707235008968 NAD(P) binding site [chemical binding]; other site 707235008969 homodimer interface [polypeptide binding]; other site 707235008970 active site 707235008971 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 707235008972 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 707235008973 putative deacylase active site [active] 707235008974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 707235008975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707235008976 Coenzyme A binding pocket [chemical binding]; other site 707235008977 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 707235008978 Phosphotransferase enzyme family; Region: APH; pfam01636 707235008979 putative active site [active] 707235008980 putative substrate binding site [chemical binding]; other site 707235008981 ATP binding site [chemical binding]; other site 707235008982 Uncharacterized conserved protein [Function unknown]; Region: COG2135 707235008983 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 707235008984 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 707235008985 hinge; other site 707235008986 active site 707235008987 Predicted GTPases [General function prediction only]; Region: COG1162 707235008988 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 707235008989 GTPase/Zn-binding domain interface [polypeptide binding]; other site 707235008990 GTP/Mg2+ binding site [chemical binding]; other site 707235008991 G4 box; other site 707235008992 G5 box; other site 707235008993 G1 box; other site 707235008994 Switch I region; other site 707235008995 G2 box; other site 707235008996 G3 box; other site 707235008997 Switch II region; other site 707235008998 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 707235008999 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 707235009000 putative di-iron ligands [ion binding]; other site 707235009001 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 707235009002 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 707235009003 FAD binding pocket [chemical binding]; other site 707235009004 FAD binding motif [chemical binding]; other site 707235009005 phosphate binding motif [ion binding]; other site 707235009006 beta-alpha-beta structure motif; other site 707235009007 NAD binding pocket [chemical binding]; other site 707235009008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235009009 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 707235009010 catalytic loop [active] 707235009011 iron binding site [ion binding]; other site 707235009012 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 707235009013 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235009014 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235009015 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 707235009016 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 707235009017 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 707235009018 TrkA-C domain; Region: TrkA_C; pfam02080 707235009019 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 707235009020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235009021 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235009022 putative substrate translocation pore; other site 707235009023 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235009024 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235009025 ligand binding site [chemical binding]; other site 707235009026 flexible hinge region; other site 707235009027 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 707235009028 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 707235009029 nucleophile elbow; other site 707235009030 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 707235009031 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 707235009032 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 707235009033 30S subunit binding site; other site 707235009034 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 707235009035 active site 707235009036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 707235009037 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 707235009038 lipoprotein LpqB; Provisional; Region: PRK13616 707235009039 Sporulation and spore germination; Region: Germane; pfam10646 707235009040 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 707235009041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235009042 dimerization interface [polypeptide binding]; other site 707235009043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235009044 dimer interface [polypeptide binding]; other site 707235009045 phosphorylation site [posttranslational modification] 707235009046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235009047 ATP binding site [chemical binding]; other site 707235009048 Mg2+ binding site [ion binding]; other site 707235009049 G-X-G motif; other site 707235009050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235009051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235009052 active site 707235009053 phosphorylation site [posttranslational modification] 707235009054 intermolecular recognition site; other site 707235009055 dimerization interface [polypeptide binding]; other site 707235009056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235009057 DNA binding site [nucleotide binding] 707235009058 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 707235009059 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 707235009060 TMP-binding site; other site 707235009061 ATP-binding site [chemical binding]; other site 707235009062 Adenosylhomocysteinase; Provisional; Region: PTZ00075 707235009063 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 707235009064 homotetramer interface [polypeptide binding]; other site 707235009065 ligand binding site [chemical binding]; other site 707235009066 catalytic site [active] 707235009067 NAD binding site [chemical binding]; other site 707235009068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235009069 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 707235009070 Rubredoxin [Energy production and conversion]; Region: COG1773 707235009071 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 707235009072 iron binding site [ion binding]; other site 707235009073 Rubredoxin [Energy production and conversion]; Region: COG1773 707235009074 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 707235009075 iron binding site [ion binding]; other site 707235009076 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 707235009077 Fatty acid desaturase; Region: FA_desaturase; pfam00487 707235009078 Di-iron ligands [ion binding]; other site 707235009079 amino acid transporter; Region: 2A0306; TIGR00909 707235009080 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 707235009081 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 707235009082 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 707235009083 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 707235009084 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 707235009085 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 707235009086 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 707235009087 active site 707235009088 substrate binding site [chemical binding]; other site 707235009089 metal binding site [ion binding]; metal-binding site 707235009090 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 707235009091 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 707235009092 Transcription factor WhiB; Region: Whib; pfam02467 707235009093 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 707235009094 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 707235009095 phosphate binding site [ion binding]; other site 707235009096 dimer interface [polypeptide binding]; other site 707235009097 substrate binding site [chemical binding]; other site 707235009098 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 707235009099 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 707235009100 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 707235009101 putative FMN binding site [chemical binding]; other site 707235009102 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 707235009103 Methyltransferase domain; Region: Methyltransf_26; pfam13659 707235009104 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 707235009105 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 707235009106 active site 707235009107 Substrate binding site; other site 707235009108 Mg++ binding site; other site 707235009109 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 707235009110 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 707235009111 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 707235009112 Probable Catalytic site; other site 707235009113 metal-binding site 707235009114 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 707235009115 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 707235009116 NADP binding site [chemical binding]; other site 707235009117 active site 707235009118 putative substrate binding site [chemical binding]; other site 707235009119 Transcriptional regulator [Transcription]; Region: LytR; COG1316 707235009120 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 707235009121 TIGR03089 family protein; Region: TIGR03089 707235009122 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 707235009123 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 707235009124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235009125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 707235009126 active site 707235009127 motif I; other site 707235009128 motif II; other site 707235009129 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 707235009130 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 707235009131 CoA-transferase family III; Region: CoA_transf_3; pfam02515 707235009132 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 707235009133 Sulfate transporter family; Region: Sulfate_transp; pfam00916 707235009134 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 707235009135 active site clefts [active] 707235009136 zinc binding site [ion binding]; other site 707235009137 dimer interface [polypeptide binding]; other site 707235009138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009139 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 707235009140 FAD binding site [chemical binding]; other site 707235009141 homotetramer interface [polypeptide binding]; other site 707235009142 substrate binding pocket [chemical binding]; other site 707235009143 catalytic base [active] 707235009144 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 707235009145 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 707235009146 ATP-grasp domain; Region: ATP-grasp; pfam02222 707235009147 Predicted membrane protein [Function unknown]; Region: COG2246 707235009148 GtrA-like protein; Region: GtrA; pfam04138 707235009149 Bacterial PH domain; Region: DUF304; pfam03703 707235009150 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 707235009151 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 707235009152 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 707235009153 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 707235009154 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 707235009155 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 707235009156 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 707235009157 Maf-like protein; Region: Maf; pfam02545 707235009158 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 707235009159 active site 707235009160 dimer interface [polypeptide binding]; other site 707235009161 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 707235009162 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 707235009163 active site residue [active] 707235009164 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 707235009165 active site residue [active] 707235009166 Fe-S metabolism associated domain; Region: SufE; pfam02657 707235009167 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 707235009168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707235009169 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 707235009170 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 707235009171 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707235009172 carboxyltransferase (CT) interaction site; other site 707235009173 biotinylation site [posttranslational modification]; other site 707235009174 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 707235009175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235009176 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 707235009177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 707235009178 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 707235009179 L-lysine aminotransferase; Provisional; Region: PRK08297 707235009180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707235009181 inhibitor-cofactor binding pocket; inhibition site 707235009182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009183 catalytic residue [active] 707235009184 putative DNA binding site [nucleotide binding]; other site 707235009185 dimerization interface [polypeptide binding]; other site 707235009186 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 707235009187 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 707235009188 putative Zn2+ binding site [ion binding]; other site 707235009189 AsnC family; Region: AsnC_trans_reg; pfam01037 707235009190 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 707235009191 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 707235009192 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 707235009193 tetrameric interface [polypeptide binding]; other site 707235009194 NAD binding site [chemical binding]; other site 707235009195 catalytic residues [active] 707235009196 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 707235009197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235009198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235009199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235009200 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 707235009201 ATP binding site [chemical binding]; other site 707235009202 putative Mg++ binding site [ion binding]; other site 707235009203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235009204 nucleotide binding region [chemical binding]; other site 707235009205 ATP-binding site [chemical binding]; other site 707235009206 DEAD/H associated; Region: DEAD_assoc; pfam08494 707235009207 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 707235009208 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 707235009209 putative DNA binding site [nucleotide binding]; other site 707235009210 catalytic residue [active] 707235009211 putative H2TH interface [polypeptide binding]; other site 707235009212 putative catalytic residues [active] 707235009213 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 707235009214 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 707235009215 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 707235009216 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 707235009217 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 707235009218 probable active site [active] 707235009219 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 707235009220 PhoU domain; Region: PhoU; pfam01895 707235009221 PhoU domain; Region: PhoU; pfam01895 707235009222 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 707235009223 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 707235009224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235009225 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707235009226 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 707235009227 putative active site pocket [active] 707235009228 dimerization interface [polypeptide binding]; other site 707235009229 putative catalytic residue [active] 707235009230 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 707235009231 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 707235009232 metal binding site [ion binding]; metal-binding site 707235009233 putative dimer interface [polypeptide binding]; other site 707235009234 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 707235009235 amidohydrolase; Region: amidohydrolases; TIGR01891 707235009236 metal binding site [ion binding]; metal-binding site 707235009237 purine nucleoside phosphorylase; Provisional; Region: PRK08202 707235009238 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 707235009239 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 707235009240 active site 707235009241 substrate binding site [chemical binding]; other site 707235009242 metal binding site [ion binding]; metal-binding site 707235009243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235009244 active site 707235009245 Phosphoesterase family; Region: Phosphoesterase; pfam04185 707235009246 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235009247 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 707235009248 adenosine deaminase; Provisional; Region: PRK09358 707235009249 active site 707235009250 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 707235009251 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 707235009252 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 707235009253 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 707235009254 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 707235009255 active site 707235009256 catalytic motif [active] 707235009257 Zn binding site [ion binding]; other site 707235009258 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 707235009259 putative Iron-sulfur protein interface [polypeptide binding]; other site 707235009260 putative proximal heme binding site [chemical binding]; other site 707235009261 putative SdhD-like interface [polypeptide binding]; other site 707235009262 putative distal heme binding site [chemical binding]; other site 707235009263 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 707235009264 putative Iron-sulfur protein interface [polypeptide binding]; other site 707235009265 putative proximal heme binding site [chemical binding]; other site 707235009266 putative SdhC-like subunit interface [polypeptide binding]; other site 707235009267 putative distal heme binding site [chemical binding]; other site 707235009268 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 707235009269 L-aspartate oxidase; Provisional; Region: PRK06175 707235009270 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 707235009271 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 707235009272 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 707235009273 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235009274 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 707235009275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235009276 S-adenosylmethionine binding site [chemical binding]; other site 707235009277 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 707235009278 MoaE interaction surface [polypeptide binding]; other site 707235009279 MoeB interaction surface [polypeptide binding]; other site 707235009280 thiocarboxylated glycine; other site 707235009281 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 707235009282 MoaE homodimer interface [polypeptide binding]; other site 707235009283 MoaD interaction [polypeptide binding]; other site 707235009284 active site residues [active] 707235009285 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 707235009286 trimer interface [polypeptide binding]; other site 707235009287 dimer interface [polypeptide binding]; other site 707235009288 putative active site [active] 707235009289 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 707235009290 aromatic arch; other site 707235009291 DCoH dimer interaction site [polypeptide binding]; other site 707235009292 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 707235009293 DCoH tetramer interaction site [polypeptide binding]; other site 707235009294 substrate binding site [chemical binding]; other site 707235009295 putative transposase OrfB; Reviewed; Region: PHA02517 707235009296 HTH-like domain; Region: HTH_21; pfam13276 707235009297 Integrase core domain; Region: rve; pfam00665 707235009298 Integrase core domain; Region: rve_3; pfam13683 707235009299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235009300 Transposase; Region: HTH_Tnp_1; cl17663 707235009301 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 707235009302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235009303 FeS/SAM binding site; other site 707235009304 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 707235009305 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 707235009306 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 707235009307 DNA binding site [nucleotide binding] 707235009308 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235009309 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235009310 phosphopeptide binding site; other site 707235009311 Condensation domain; Region: Condensation; pfam00668 707235009312 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235009313 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 707235009314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235009315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235009316 DNA binding residues [nucleotide binding] 707235009317 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235009318 hypothetical protein; Provisional; Region: PRK06541 707235009319 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707235009320 inhibitor-cofactor binding pocket; inhibition site 707235009321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009322 catalytic residue [active] 707235009323 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 707235009324 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 707235009325 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 707235009326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235009327 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 707235009328 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 707235009329 active site 707235009330 dimer interface [polypeptide binding]; other site 707235009331 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235009332 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 707235009333 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 707235009334 DNA binding residues [nucleotide binding] 707235009335 dimer interface [polypeptide binding]; other site 707235009336 metal binding site [ion binding]; metal-binding site 707235009337 inner membrane protein YhjD; Region: TIGR00766 707235009338 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 707235009339 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 707235009340 active site 707235009341 HIGH motif; other site 707235009342 dimer interface [polypeptide binding]; other site 707235009343 KMSKS motif; other site 707235009344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707235009345 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 707235009346 isocitrate dehydrogenase; Validated; Region: PRK08299 707235009347 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 707235009348 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 707235009349 homodimer interface [polypeptide binding]; other site 707235009350 substrate-cofactor binding pocket; other site 707235009351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009352 catalytic residue [active] 707235009353 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 707235009354 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 707235009355 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235009356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235009357 S-adenosylmethionine binding site [chemical binding]; other site 707235009358 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009359 PPE family; Region: PPE; pfam00823 707235009360 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009361 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009362 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009363 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009364 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009365 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009366 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009367 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009368 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009369 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009370 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009371 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009372 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009373 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009374 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009375 PE family; Region: PE; pfam00934 707235009376 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 707235009377 PPE family; Region: PPE; pfam00823 707235009378 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009379 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009380 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009381 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009382 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009383 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009384 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009385 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009386 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009387 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009388 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009389 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235009390 Transposase; Region: DDE_Tnp_ISL3; pfam01610 707235009391 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009392 PPE family; Region: PPE; pfam00823 707235009393 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009394 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009395 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009396 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009397 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009398 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009399 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009400 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009401 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009402 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009403 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009404 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009405 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009406 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009407 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009408 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009409 Berberine and berberine like; Region: BBE; pfam08031 707235009410 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235009411 Protein of unknown function (DUF732); Region: DUF732; pfam05305 707235009412 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 707235009413 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 707235009414 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 707235009415 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 707235009416 homodimer interface [polypeptide binding]; other site 707235009417 NADP binding site [chemical binding]; other site 707235009418 substrate binding site [chemical binding]; other site 707235009419 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 707235009420 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 707235009421 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 707235009422 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 707235009423 active site 707235009424 FMN binding site [chemical binding]; other site 707235009425 substrate binding site [chemical binding]; other site 707235009426 putative catalytic residue [active] 707235009427 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235009428 phosphate binding site [ion binding]; other site 707235009429 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235009430 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707235009431 phosphopeptide binding site; other site 707235009432 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 707235009433 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 707235009434 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 707235009435 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 707235009436 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 707235009437 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 707235009438 G1 box; other site 707235009439 GTP/Mg2+ binding site [chemical binding]; other site 707235009440 G2 box; other site 707235009441 Switch I region; other site 707235009442 G3 box; other site 707235009443 Switch II region; other site 707235009444 G4 box; other site 707235009445 G5 box; other site 707235009446 Protein of unknown function (DUF742); Region: DUF742; pfam05331 707235009447 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 707235009448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235009449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235009450 ATP binding site [chemical binding]; other site 707235009451 Mg2+ binding site [ion binding]; other site 707235009452 G-X-G motif; other site 707235009453 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 707235009454 PE family; Region: PE; pfam00934 707235009455 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 707235009456 FMN binding site [chemical binding]; other site 707235009457 dimer interface [polypeptide binding]; other site 707235009458 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 707235009459 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 707235009460 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 707235009461 active site 707235009462 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 707235009463 generic binding surface II; other site 707235009464 generic binding surface I; other site 707235009465 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235009466 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235009467 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 707235009468 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 707235009469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235009470 active site 707235009471 motif I; other site 707235009472 motif II; other site 707235009473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235009474 substrate binding site [chemical binding]; other site 707235009475 oxyanion hole (OAH) forming residues; other site 707235009476 trimer interface [polypeptide binding]; other site 707235009477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 707235009478 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 707235009479 Amidase; Region: Amidase; pfam01425 707235009480 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 707235009481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235009482 motif II; other site 707235009483 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 707235009484 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 707235009485 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 707235009486 TPP-binding site [chemical binding]; other site 707235009487 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 707235009488 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 707235009489 PYR/PP interface [polypeptide binding]; other site 707235009490 dimer interface [polypeptide binding]; other site 707235009491 TPP binding site [chemical binding]; other site 707235009492 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707235009493 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 707235009494 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 707235009495 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707235009496 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707235009497 substrate binding pocket [chemical binding]; other site 707235009498 chain length determination region; other site 707235009499 substrate-Mg2+ binding site; other site 707235009500 catalytic residues [active] 707235009501 aspartate-rich region 1; other site 707235009502 active site lid residues [active] 707235009503 aspartate-rich region 2; other site 707235009504 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 707235009505 putative active site [active] 707235009506 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235009507 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 707235009508 Transposase domain (DUF772); Region: DUF772; pfam05598 707235009509 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 707235009510 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 707235009511 PE family; Region: PE; pfam00934 707235009512 enoyl-CoA hydratase; Region: PLN02864 707235009513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 707235009514 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 707235009515 dimer interaction site [polypeptide binding]; other site 707235009516 substrate-binding tunnel; other site 707235009517 active site 707235009518 catalytic site [active] 707235009519 substrate binding site [chemical binding]; other site 707235009520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235009521 short chain dehydrogenase; Provisional; Region: PRK07201 707235009522 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 707235009523 putative NAD(P) binding site [chemical binding]; other site 707235009524 active site 707235009525 putative substrate binding site [chemical binding]; other site 707235009526 classical (c) SDRs; Region: SDR_c; cd05233 707235009527 NAD(P) binding site [chemical binding]; other site 707235009528 active site 707235009529 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235009530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235009531 S-adenosylmethionine binding site [chemical binding]; other site 707235009532 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 707235009533 active site 707235009534 DNA Polymerase Y-family; Region: PolY_like; cd03468 707235009535 DNA binding site [nucleotide binding] 707235009536 GMP synthase; Reviewed; Region: guaA; PRK00074 707235009537 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 707235009538 AMP/PPi binding site [chemical binding]; other site 707235009539 candidate oxyanion hole; other site 707235009540 catalytic triad [active] 707235009541 potential glutamine specificity residues [chemical binding]; other site 707235009542 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 707235009543 ATP Binding subdomain [chemical binding]; other site 707235009544 Ligand Binding sites [chemical binding]; other site 707235009545 Dimerization subdomain; other site 707235009546 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 707235009547 active site lid residues [active] 707235009548 substrate binding pocket [chemical binding]; other site 707235009549 catalytic residues [active] 707235009550 substrate-Mg2+ binding site; other site 707235009551 aspartate-rich region 1; other site 707235009552 aspartate-rich region 2; other site 707235009553 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707235009554 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707235009555 substrate binding pocket [chemical binding]; other site 707235009556 chain length determination region; other site 707235009557 substrate-Mg2+ binding site; other site 707235009558 catalytic residues [active] 707235009559 aspartate-rich region 1; other site 707235009560 active site lid residues [active] 707235009561 aspartate-rich region 2; other site 707235009562 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235009563 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235009564 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 707235009565 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 707235009566 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 707235009567 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 707235009568 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 707235009569 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 707235009570 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 707235009571 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 707235009572 inhibitor-cofactor binding pocket; inhibition site 707235009573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009574 catalytic residue [active] 707235009575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 707235009576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235009577 hypothetical protein; Provisional; Region: PRK07579 707235009578 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 707235009579 active site 707235009580 cosubstrate binding site; other site 707235009581 substrate binding site [chemical binding]; other site 707235009582 catalytic site [active] 707235009583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235009584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235009585 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 707235009586 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 707235009587 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 707235009588 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 707235009589 putative active site [active] 707235009590 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 707235009591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235009592 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 707235009593 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 707235009594 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235009595 phosphate binding site [ion binding]; other site 707235009596 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 707235009597 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 707235009598 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 707235009599 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 707235009600 active site 707235009601 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 707235009602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235009603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235009604 DNA binding residues [nucleotide binding] 707235009605 Transcription factor WhiB; Region: Whib; pfam02467 707235009606 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 707235009607 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 707235009608 ring oligomerisation interface [polypeptide binding]; other site 707235009609 ATP/Mg binding site [chemical binding]; other site 707235009610 stacking interactions; other site 707235009611 hinge regions; other site 707235009612 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 707235009613 oligomerisation interface [polypeptide binding]; other site 707235009614 mobile loop; other site 707235009615 roof hairpin; other site 707235009616 UGMP family protein; Validated; Region: PRK09604 707235009617 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 707235009618 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 707235009619 Coenzyme A binding pocket [chemical binding]; other site 707235009620 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 707235009621 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 707235009622 alanine racemase; Reviewed; Region: alr; PRK00053 707235009623 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 707235009624 active site 707235009625 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 707235009626 dimer interface [polypeptide binding]; other site 707235009627 substrate binding site [chemical binding]; other site 707235009628 catalytic residues [active] 707235009629 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009630 PPE family; Region: PPE; pfam00823 707235009631 Integrase core domain; Region: rve; pfam00665 707235009632 Integrase core domain; Region: rve_3; pfam13683 707235009633 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235009634 MULE transposase domain; Region: MULE; pfam10551 707235009635 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 707235009636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009637 catalytic residue [active] 707235009638 Uncharacterized conserved protein [Function unknown]; Region: COG0062 707235009639 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 707235009640 putative substrate binding site [chemical binding]; other site 707235009641 putative ATP binding site [chemical binding]; other site 707235009642 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 707235009643 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 707235009644 glutaminase active site [active] 707235009645 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 707235009646 dimer interface [polypeptide binding]; other site 707235009647 active site 707235009648 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 707235009649 dimer interface [polypeptide binding]; other site 707235009650 active site 707235009651 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 707235009652 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 707235009653 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 707235009654 active site 707235009655 substrate binding site [chemical binding]; other site 707235009656 metal binding site [ion binding]; metal-binding site 707235009657 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 707235009658 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 707235009659 23S rRNA interface [nucleotide binding]; other site 707235009660 L3 interface [polypeptide binding]; other site 707235009661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235009662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235009663 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 707235009664 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 707235009665 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235009666 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 707235009667 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235009668 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235009669 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 707235009670 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 707235009671 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235009672 active site 707235009673 catalytic residues [active] 707235009674 Protein of unknown function (DUF690); Region: DUF690; pfam05108 707235009675 Cutinase; Region: Cutinase; pfam01083 707235009676 Cutinase; Region: Cutinase; pfam01083 707235009677 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 707235009678 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 707235009679 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 707235009680 dimerization interface 3.5A [polypeptide binding]; other site 707235009681 active site 707235009682 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 707235009683 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 707235009684 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 707235009685 alphaNTD - beta interaction site [polypeptide binding]; other site 707235009686 alphaNTD homodimer interface [polypeptide binding]; other site 707235009687 alphaNTD - beta' interaction site [polypeptide binding]; other site 707235009688 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 707235009689 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 707235009690 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 707235009691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707235009692 RNA binding surface [nucleotide binding]; other site 707235009693 30S ribosomal protein S11; Validated; Region: PRK05309 707235009694 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 707235009695 30S ribosomal protein S13; Region: bact_S13; TIGR03631 707235009696 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 707235009697 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 707235009698 rRNA binding site [nucleotide binding]; other site 707235009699 predicted 30S ribosome binding site; other site 707235009700 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 707235009701 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 707235009702 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 707235009703 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 707235009704 NAD binding site [chemical binding]; other site 707235009705 substrate binding site [chemical binding]; other site 707235009706 homodimer interface [polypeptide binding]; other site 707235009707 active site 707235009708 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 707235009709 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235009710 Domain of unknown function (DUF222); Region: DUF222; pfam02720 707235009711 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 707235009712 active site 707235009713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235009714 extended (e) SDRs; Region: SDR_e; cd08946 707235009715 NAD(P) binding site [chemical binding]; other site 707235009716 active site 707235009717 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 707235009718 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 707235009719 active site 707235009720 catalytic residues [active] 707235009721 metal binding site [ion binding]; metal-binding site 707235009722 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 707235009723 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 707235009724 PYR/PP interface [polypeptide binding]; other site 707235009725 dimer interface [polypeptide binding]; other site 707235009726 TPP binding site [chemical binding]; other site 707235009727 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 707235009728 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 707235009729 TPP-binding site [chemical binding]; other site 707235009730 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 707235009731 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 707235009732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235009733 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 707235009734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235009735 metabolite-proton symporter; Region: 2A0106; TIGR00883 707235009736 putative substrate translocation pore; other site 707235009737 PE family; Region: PE; pfam00934 707235009738 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009739 PPE family; Region: PPE; pfam00823 707235009740 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235009741 patatin-related protein; Region: TIGR03607 707235009742 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235009743 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235009744 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 707235009745 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 707235009746 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 707235009747 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 707235009748 Transcriptional regulator [Transcription]; Region: LytR; COG1316 707235009749 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 707235009750 short chain dehydrogenase; Provisional; Region: PRK05875 707235009751 classical (c) SDRs; Region: SDR_c; cd05233 707235009752 NAD(P) binding site [chemical binding]; other site 707235009753 active site 707235009754 Predicted membrane protein [Function unknown]; Region: COG2259 707235009755 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 707235009756 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 707235009757 Predicted transcriptional regulators [Transcription]; Region: COG1695 707235009758 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 707235009759 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 707235009760 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 707235009761 active site 707235009762 homotetramer interface [polypeptide binding]; other site 707235009763 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009764 mce related protein; Region: MCE; pfam02470 707235009765 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009766 mce related protein; Region: MCE; pfam02470 707235009767 mce related protein; Region: MCE; pfam02470 707235009768 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009769 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235009770 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009771 mce related protein; Region: MCE; pfam02470 707235009772 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009773 mce related protein; Region: MCE; pfam02470 707235009774 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 707235009775 mce related protein; Region: MCE; pfam02470 707235009776 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 707235009777 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235009778 Permease; Region: Permease; pfam02405 707235009779 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 707235009780 Permease; Region: Permease; pfam02405 707235009781 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 707235009782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235009783 NAD(P) binding site [chemical binding]; other site 707235009784 active site 707235009785 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 707235009786 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 707235009787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009788 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 707235009789 FAD binding site [chemical binding]; other site 707235009790 substrate binding site [chemical binding]; other site 707235009791 catalytic base [active] 707235009792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009794 active site 707235009795 acyl-CoA synthetase; Validated; Region: PRK07867 707235009796 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 707235009797 acyl-activating enzyme (AAE) consensus motif; other site 707235009798 putative AMP binding site [chemical binding]; other site 707235009799 putative active site [active] 707235009800 putative CoA binding site [chemical binding]; other site 707235009801 PE family; Region: PE; pfam00934 707235009802 PE family; Region: PE; pfam00934 707235009803 hypothetical protein; Validated; Region: PRK07586 707235009804 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 707235009805 PYR/PP interface [polypeptide binding]; other site 707235009806 dimer interface [polypeptide binding]; other site 707235009807 TPP binding site [chemical binding]; other site 707235009808 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 707235009809 TPP-binding site [chemical binding]; other site 707235009810 dimer interface [polypeptide binding]; other site 707235009811 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 707235009812 PE family; Region: PE; pfam00934 707235009813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235009814 CoA binding site [chemical binding]; other site 707235009815 acyl-CoA synthetase; Validated; Region: PRK07798 707235009816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235009817 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 707235009818 acyl-activating enzyme (AAE) consensus motif; other site 707235009819 acyl-activating enzyme (AAE) consensus motif; other site 707235009820 putative AMP binding site [chemical binding]; other site 707235009821 putative active site [active] 707235009822 putative CoA binding site [chemical binding]; other site 707235009823 enoyl-CoA hydratase; Provisional; Region: PRK07799 707235009824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235009825 substrate binding site [chemical binding]; other site 707235009826 oxyanion hole (OAH) forming residues; other site 707235009827 trimer interface [polypeptide binding]; other site 707235009828 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235009829 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235009830 Cytochrome P450; Region: p450; cl12078 707235009831 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 707235009832 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 707235009833 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 707235009834 DUF35 OB-fold domain; Region: DUF35; pfam01796 707235009835 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 707235009836 DUF35 OB-fold domain; Region: DUF35; pfam01796 707235009837 lipid-transfer protein; Provisional; Region: PRK07937 707235009838 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235009839 active site 707235009840 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 707235009841 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235009842 active site 707235009843 NHL repeat; Region: NHL; pfam01436 707235009844 Uncharacterized conserved protein [Function unknown]; Region: COG3391 707235009845 NHL repeat; Region: NHL; pfam01436 707235009846 NHL repeat; Region: NHL; pfam01436 707235009847 NHL repeat; Region: NHL; pfam01436 707235009848 NHL repeat; Region: NHL; pfam01436 707235009849 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 707235009850 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 707235009851 trimer interface [polypeptide binding]; other site 707235009852 putative metal binding site [ion binding]; other site 707235009853 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 707235009854 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 707235009855 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 707235009856 short chain dehydrogenase; Provisional; Region: PRK07890 707235009857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235009858 NAD(P) binding site [chemical binding]; other site 707235009859 active site 707235009860 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009861 PPE family; Region: PPE; pfam00823 707235009862 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 707235009863 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009864 PPE family; Region: PPE; pfam00823 707235009865 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009866 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 707235009867 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 707235009868 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 707235009869 active site 707235009870 catalytic residues [active] 707235009871 metal binding site [ion binding]; metal-binding site 707235009872 DmpG-like communication domain; Region: DmpG_comm; pfam07836 707235009873 acetaldehyde dehydrogenase; Validated; Region: PRK08300 707235009874 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 707235009875 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 707235009876 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 707235009877 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 707235009878 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 707235009879 enoyl-CoA hydratase; Region: PLN02864 707235009880 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 707235009881 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 707235009882 dimer interaction site [polypeptide binding]; other site 707235009883 substrate-binding tunnel; other site 707235009884 active site 707235009885 catalytic site [active] 707235009886 substrate binding site [chemical binding]; other site 707235009887 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009888 PPE family; Region: PPE; pfam00823 707235009889 PE-PPE domain; Region: PE-PPE; pfam08237 707235009890 lipid-transfer protein; Provisional; Region: PRK07855 707235009891 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 707235009892 active site 707235009893 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 707235009894 putative active site [active] 707235009895 putative catalytic site [active] 707235009896 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 707235009897 active site 707235009898 catalytic site [active] 707235009899 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 707235009900 DUF35 OB-fold domain; Region: DUF35; pfam01796 707235009901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009903 active site 707235009904 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009905 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 707235009906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009907 active site 707235009908 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235009909 Cytochrome P450; Region: p450; cl12078 707235009910 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 707235009911 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235009912 dimer interface [polypeptide binding]; other site 707235009913 active site 707235009914 Domain of unknown function (DUF385); Region: DUF385; pfam04075 707235009915 short chain dehydrogenase; Provisional; Region: PRK07791 707235009916 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 707235009917 homodimer interface [polypeptide binding]; other site 707235009918 NAD binding site [chemical binding]; other site 707235009919 active site 707235009920 short chain dehydrogenase; Provisional; Region: PRK07856 707235009921 classical (c) SDRs; Region: SDR_c; cd05233 707235009922 NAD(P) binding site [chemical binding]; other site 707235009923 active site 707235009924 enoyl-CoA hydratase; Provisional; Region: PRK06495 707235009925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235009926 substrate binding site [chemical binding]; other site 707235009927 oxyanion hole (OAH) forming residues; other site 707235009928 trimer interface [polypeptide binding]; other site 707235009929 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 707235009930 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 707235009931 Nitronate monooxygenase; Region: NMO; pfam03060 707235009932 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 707235009933 FMN binding site [chemical binding]; other site 707235009934 substrate binding site [chemical binding]; other site 707235009935 putative catalytic residue [active] 707235009936 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 707235009937 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 707235009938 putative di-iron ligands [ion binding]; other site 707235009939 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 707235009940 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 707235009941 FAD binding pocket [chemical binding]; other site 707235009942 FAD binding motif [chemical binding]; other site 707235009943 phosphate binding motif [ion binding]; other site 707235009944 beta-alpha-beta structure motif; other site 707235009945 NAD(p) ribose binding residues [chemical binding]; other site 707235009946 NAD binding pocket [chemical binding]; other site 707235009947 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 707235009948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235009949 catalytic loop [active] 707235009950 iron binding site [ion binding]; other site 707235009951 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 707235009952 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 707235009953 putative active site [active] 707235009954 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 707235009955 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 707235009956 dimer interface [polypeptide binding]; other site 707235009957 active site 707235009958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235009959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235009960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235009961 PPE family; Region: PPE; pfam00823 707235009962 short chain dehydrogenase; Provisional; Region: PRK07831 707235009963 classical (c) SDRs; Region: SDR_c; cd05233 707235009964 NAD(P) binding site [chemical binding]; other site 707235009965 active site 707235009966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009968 active site 707235009969 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 707235009970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707235009971 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 707235009972 acyl-activating enzyme (AAE) consensus motif; other site 707235009973 putative AMP binding site [chemical binding]; other site 707235009974 putative active site [active] 707235009975 putative CoA binding site [chemical binding]; other site 707235009976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009978 active site 707235009979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009980 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 707235009981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009983 active site 707235009984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235009985 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 707235009986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235009987 active site 707235009988 aspartate aminotransferase; Provisional; Region: PRK05764 707235009989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235009990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235009991 homodimer interface [polypeptide binding]; other site 707235009992 catalytic residue [active] 707235009993 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 707235009994 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 707235009995 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 707235009996 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 707235009997 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 707235009998 active site 707235009999 Fe binding site [ion binding]; other site 707235010000 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 707235010001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235010002 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 707235010003 Flavin binding site [chemical binding]; other site 707235010004 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 707235010005 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 707235010006 FAD binding pocket [chemical binding]; other site 707235010007 FAD binding motif [chemical binding]; other site 707235010008 phosphate binding motif [ion binding]; other site 707235010009 beta-alpha-beta structure motif; other site 707235010010 NAD(p) ribose binding residues [chemical binding]; other site 707235010011 NAD binding pocket [chemical binding]; other site 707235010012 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 707235010013 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 707235010014 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707235010015 catalytic loop [active] 707235010016 iron binding site [ion binding]; other site 707235010017 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235010018 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235010019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 707235010020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235010021 active site 707235010022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235010023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235010024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 707235010025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 707235010026 DNA binding site [nucleotide binding] 707235010027 domain linker motif; other site 707235010028 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 707235010029 putative dimerization interface [polypeptide binding]; other site 707235010030 putative ligand binding site [chemical binding]; other site 707235010031 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235010032 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 707235010033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 707235010034 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 707235010035 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 707235010036 transmembrane helices; other site 707235010037 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 707235010038 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 707235010039 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 707235010040 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 707235010041 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 707235010042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707235010043 active site 707235010044 HIGH motif; other site 707235010045 nucleotide binding site [chemical binding]; other site 707235010046 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 707235010047 KMSKS motif; other site 707235010048 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 707235010049 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 707235010050 homotrimer interaction site [polypeptide binding]; other site 707235010051 zinc binding site [ion binding]; other site 707235010052 CDP-binding sites; other site 707235010053 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 707235010054 substrate binding site; other site 707235010055 dimer interface; other site 707235010056 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 707235010057 DNA repair protein RadA; Provisional; Region: PRK11823 707235010058 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 707235010059 Walker A motif/ATP binding site; other site 707235010060 ATP binding site [chemical binding]; other site 707235010061 Walker B motif; other site 707235010062 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 707235010063 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 707235010064 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 707235010065 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 707235010066 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 707235010067 active site clefts [active] 707235010068 zinc binding site [ion binding]; other site 707235010069 dimer interface [polypeptide binding]; other site 707235010070 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707235010071 endonuclease III; Region: ENDO3c; smart00478 707235010072 minor groove reading motif; other site 707235010073 helix-hairpin-helix signature motif; other site 707235010074 substrate binding pocket [chemical binding]; other site 707235010075 active site 707235010076 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 707235010077 PE family; Region: PE; pfam00934 707235010078 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235010079 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 707235010080 catalytic site [active] 707235010081 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 707235010082 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 707235010083 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 707235010084 Ami_2 domain; Region: Ami_2; smart00644 707235010085 amidase catalytic site [active] 707235010086 Zn binding residues [ion binding]; other site 707235010087 substrate binding site [chemical binding]; other site 707235010088 PE family; Region: PE; pfam00934 707235010089 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 707235010090 Clp amino terminal domain; Region: Clp_N; pfam02861 707235010091 Clp amino terminal domain; Region: Clp_N; pfam02861 707235010092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010093 Walker A motif; other site 707235010094 ATP binding site [chemical binding]; other site 707235010095 Walker B motif; other site 707235010096 arginine finger; other site 707235010097 UvrB/uvrC motif; Region: UVR; pfam02151 707235010098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010099 Walker A motif; other site 707235010100 ATP binding site [chemical binding]; other site 707235010101 Walker B motif; other site 707235010102 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 707235010103 Lsr2; Region: Lsr2; pfam11774 707235010104 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 707235010105 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 707235010106 dimer interface [polypeptide binding]; other site 707235010107 putative anticodon binding site; other site 707235010108 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707235010109 motif 1; other site 707235010110 dimer interface [polypeptide binding]; other site 707235010111 active site 707235010112 motif 2; other site 707235010113 motif 3; other site 707235010114 pantothenate kinase; Reviewed; Region: PRK13318 707235010115 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 707235010116 tetramerization interface [polypeptide binding]; other site 707235010117 active site 707235010118 Pantoate-beta-alanine ligase; Region: PanC; cd00560 707235010119 pantoate--beta-alanine ligase; Region: panC; TIGR00018 707235010120 active site 707235010121 ATP-binding site [chemical binding]; other site 707235010122 pantoate-binding site; other site 707235010123 HXXH motif; other site 707235010124 Rossmann-like domain; Region: Rossmann-like; pfam10727 707235010125 Uncharacterized conserved protein [Function unknown]; Region: COG5495 707235010126 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 707235010127 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 707235010128 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 707235010129 catalytic center binding site [active] 707235010130 ATP binding site [chemical binding]; other site 707235010131 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 707235010132 homooctamer interface [polypeptide binding]; other site 707235010133 active site 707235010134 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 707235010135 dihydropteroate synthase; Region: DHPS; TIGR01496 707235010136 substrate binding pocket [chemical binding]; other site 707235010137 dimer interface [polypeptide binding]; other site 707235010138 inhibitor binding site; inhibition site 707235010139 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 707235010140 homodecamer interface [polypeptide binding]; other site 707235010141 GTP cyclohydrolase I; Provisional; Region: PLN03044 707235010142 active site 707235010143 putative catalytic site residues [active] 707235010144 zinc binding site [ion binding]; other site 707235010145 GTP-CH-I/GFRP interaction surface; other site 707235010146 FtsH Extracellular; Region: FtsH_ext; pfam06480 707235010147 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 707235010148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010149 Walker A motif; other site 707235010150 ATP binding site [chemical binding]; other site 707235010151 Walker B motif; other site 707235010152 arginine finger; other site 707235010153 Peptidase family M41; Region: Peptidase_M41; pfam01434 707235010154 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 707235010155 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 707235010156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235010157 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707235010158 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 707235010159 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 707235010160 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235010161 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 707235010162 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235010163 PPE family; Region: PPE; pfam00823 707235010164 PE family; Region: PE; pfam00934 707235010165 Uncharacterized conserved protein [Function unknown]; Region: COG2968 707235010166 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 707235010167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 707235010168 active site 707235010169 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 707235010170 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 707235010171 Ligand Binding Site [chemical binding]; other site 707235010172 Uncharacterized conserved protein [Function unknown]; Region: COG5282 707235010173 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 707235010174 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 707235010175 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 707235010176 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 707235010177 dimer interface [polypeptide binding]; other site 707235010178 substrate binding site [chemical binding]; other site 707235010179 metal binding sites [ion binding]; metal-binding site 707235010180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 707235010181 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 707235010182 Ligand binding site; other site 707235010183 Putative Catalytic site; other site 707235010184 DXD motif; other site 707235010185 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 707235010186 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 707235010187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235010188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235010189 NAD(P) binding site [chemical binding]; other site 707235010190 active site 707235010191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 707235010192 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 707235010193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 707235010194 transposase; Provisional; Region: PRK06526 707235010195 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 707235010196 Walker B motif; other site 707235010197 putative transposase OrfB; Reviewed; Region: PHA02517 707235010198 HTH-like domain; Region: HTH_21; pfam13276 707235010199 Integrase core domain; Region: rve; pfam00665 707235010200 Integrase core domain; Region: rve_3; pfam13683 707235010201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 707235010202 Transposase; Region: HTH_Tnp_1; cl17663 707235010203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 707235010204 MULE transposase domain; Region: MULE; pfam10551 707235010205 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 707235010206 Fic/DOC family; Region: Fic; cl00960 707235010207 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 707235010208 DNA polymerase III subunit delta'; Validated; Region: PRK07940 707235010209 DNA polymerase III subunit delta'; Validated; Region: PRK08485 707235010210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 707235010211 dimerization interface [polypeptide binding]; other site 707235010212 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 707235010213 cyclase homology domain; Region: CHD; cd07302 707235010214 nucleotidyl binding site; other site 707235010215 metal binding site [ion binding]; metal-binding site 707235010216 dimer interface [polypeptide binding]; other site 707235010217 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 707235010218 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 707235010219 active site 707235010220 interdomain interaction site; other site 707235010221 putative metal-binding site [ion binding]; other site 707235010222 nucleotide binding site [chemical binding]; other site 707235010223 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 707235010224 domain I; other site 707235010225 phosphate binding site [ion binding]; other site 707235010226 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 707235010227 domain II; other site 707235010228 domain III; other site 707235010229 nucleotide binding site [chemical binding]; other site 707235010230 DNA binding groove [nucleotide binding] 707235010231 catalytic site [active] 707235010232 domain IV; other site 707235010233 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 707235010234 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 707235010235 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 707235010236 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 707235010237 DNA-binding site [nucleotide binding]; DNA binding site 707235010238 RNA-binding motif; other site 707235010239 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 707235010240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707235010241 ATP binding site [chemical binding]; other site 707235010242 putative Mg++ binding site [ion binding]; other site 707235010243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707235010244 nucleotide binding region [chemical binding]; other site 707235010245 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 707235010246 PE family; Region: PE; pfam00934 707235010247 PE family; Region: PE; pfam00934 707235010248 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 707235010249 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 707235010250 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 707235010251 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 707235010252 Walker A motif; other site 707235010253 hexamer interface [polypeptide binding]; other site 707235010254 ATP binding site [chemical binding]; other site 707235010255 Walker B motif; other site 707235010256 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 707235010257 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 707235010258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235010259 motif II; other site 707235010260 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 707235010261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707235010262 Walker A/P-loop; other site 707235010263 ATP binding site [chemical binding]; other site 707235010264 Q-loop/lid; other site 707235010265 ABC transporter signature motif; other site 707235010266 Walker B; other site 707235010267 D-loop; other site 707235010268 H-loop/switch region; other site 707235010269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707235010270 Walker A/P-loop; other site 707235010271 ATP binding site [chemical binding]; other site 707235010272 Q-loop/lid; other site 707235010273 ABC transporter signature motif; other site 707235010274 Walker B; other site 707235010275 D-loop; other site 707235010276 H-loop/switch region; other site 707235010277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 707235010278 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 707235010279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235010280 ABC-ATPase subunit interface; other site 707235010281 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 707235010282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235010283 dimer interface [polypeptide binding]; other site 707235010284 conserved gate region; other site 707235010285 ABC-ATPase subunit interface; other site 707235010286 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 707235010287 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 707235010288 acetyl-CoA synthetase; Provisional; Region: PRK00174 707235010289 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 707235010290 active site 707235010291 CoA binding site [chemical binding]; other site 707235010292 acyl-activating enzyme (AAE) consensus motif; other site 707235010293 AMP binding site [chemical binding]; other site 707235010294 acetate binding site [chemical binding]; other site 707235010295 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 707235010296 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 707235010297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707235010298 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 707235010299 putative active site [active] 707235010300 putative CoA binding site [chemical binding]; other site 707235010301 nudix motif; other site 707235010302 metal binding site [ion binding]; metal-binding site 707235010303 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 707235010304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235010305 catalytic residues [active] 707235010306 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 707235010307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707235010308 minor groove reading motif; other site 707235010309 helix-hairpin-helix signature motif; other site 707235010310 substrate binding pocket [chemical binding]; other site 707235010311 active site 707235010312 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 707235010313 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235010314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235010315 ligand binding site [chemical binding]; other site 707235010316 flexible hinge region; other site 707235010317 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 707235010318 putative switch regulator; other site 707235010319 non-specific DNA interactions [nucleotide binding]; other site 707235010320 DNA binding site [nucleotide binding] 707235010321 sequence specific DNA binding site [nucleotide binding]; other site 707235010322 putative cAMP binding site [chemical binding]; other site 707235010323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 707235010324 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 707235010325 homotrimer interaction site [polypeptide binding]; other site 707235010326 putative active site [active] 707235010327 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 707235010328 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 707235010329 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 707235010330 P loop; other site 707235010331 Nucleotide binding site [chemical binding]; other site 707235010332 DTAP/Switch II; other site 707235010333 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 707235010334 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 707235010335 DTAP/Switch II; other site 707235010336 Switch I; other site 707235010337 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 707235010338 Transcription factor WhiB; Region: Whib; pfam02467 707235010339 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 707235010340 Transglycosylase; Region: Transgly; pfam00912 707235010341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 707235010342 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 707235010343 phosphodiesterase YaeI; Provisional; Region: PRK11340 707235010344 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 707235010345 putative active site [active] 707235010346 putative metal binding site [ion binding]; other site 707235010347 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 707235010348 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 707235010349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235010350 catalytic residue [active] 707235010351 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 707235010352 Cytochrome P450; Region: p450; cl12078 707235010353 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707235010354 anti sigma factor interaction site; other site 707235010355 regulatory phosphorylation site [posttranslational modification]; other site 707235010356 Uncharacterized conserved protein [Function unknown]; Region: COG1610 707235010357 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 707235010358 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 707235010359 MoxR-like ATPases [General function prediction only]; Region: COG0714 707235010360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010361 Walker A motif; other site 707235010362 ATP binding site [chemical binding]; other site 707235010363 Walker B motif; other site 707235010364 arginine finger; other site 707235010365 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 707235010366 Protein of unknown function DUF58; Region: DUF58; pfam01882 707235010367 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 707235010368 Predicted membrane protein/domain [Function unknown]; Region: COG1714 707235010369 glycerol kinase; Provisional; Region: glpK; PRK00047 707235010370 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707235010371 nucleotide binding site [chemical binding]; other site 707235010372 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 707235010373 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 707235010374 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707235010375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235010376 S-adenosylmethionine binding site [chemical binding]; other site 707235010377 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235010378 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 707235010379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235010380 catalytic residue [active] 707235010381 Uncharacterized conserved protein [Function unknown]; Region: COG4301 707235010382 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 707235010383 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 707235010384 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 707235010385 putative active site [active] 707235010386 putative dimer interface [polypeptide binding]; other site 707235010387 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 707235010388 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 707235010389 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 707235010390 PknH-like extracellular domain; Region: PknH_C; pfam14032 707235010391 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 707235010392 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 707235010393 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 707235010394 aspartate kinase; Reviewed; Region: PRK06635 707235010395 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 707235010396 putative nucleotide binding site [chemical binding]; other site 707235010397 putative catalytic residues [active] 707235010398 putative Mg ion binding site [ion binding]; other site 707235010399 putative aspartate binding site [chemical binding]; other site 707235010400 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 707235010401 putative allosteric regulatory site; other site 707235010402 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 707235010403 putative allosteric regulatory residue; other site 707235010404 2-isopropylmalate synthase; Validated; Region: PRK03739 707235010405 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 707235010406 active site 707235010407 catalytic residues [active] 707235010408 metal binding site [ion binding]; metal-binding site 707235010409 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 707235010410 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 707235010411 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 707235010412 active site 707235010413 catalytic site [active] 707235010414 substrate binding site [chemical binding]; other site 707235010415 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 707235010416 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 707235010417 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 707235010418 catalytic triad [active] 707235010419 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 707235010420 putative active site [active] 707235010421 recombination protein RecR; Reviewed; Region: recR; PRK00076 707235010422 RecR protein; Region: RecR; pfam02132 707235010423 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 707235010424 putative active site [active] 707235010425 putative metal-binding site [ion binding]; other site 707235010426 tetramer interface [polypeptide binding]; other site 707235010427 hypothetical protein; Validated; Region: PRK00153 707235010428 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 707235010429 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 707235010430 active site 707235010431 metal binding site [ion binding]; metal-binding site 707235010432 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 707235010433 hydrophobic ligand binding site; other site 707235010434 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235010435 FAD binding domain; Region: FAD_binding_4; pfam01565 707235010436 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 707235010437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235010438 S-adenosylmethionine binding site [chemical binding]; other site 707235010439 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 707235010440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010441 Walker A motif; other site 707235010442 ATP binding site [chemical binding]; other site 707235010443 Walker B motif; other site 707235010444 arginine finger; other site 707235010445 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 707235010446 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 707235010447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707235010448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235010449 catalytic residue [active] 707235010450 Cutinase; Region: Cutinase; pfam01083 707235010451 Cutinase; Region: Cutinase; pfam01083 707235010452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235010453 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 707235010454 NAD(P) binding site [chemical binding]; other site 707235010455 active site 707235010456 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 707235010457 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 707235010458 putative NAD(P) binding site [chemical binding]; other site 707235010459 catalytic Zn binding site [ion binding]; other site 707235010460 Uncharacterized conserved protein [Function unknown]; Region: COG3349 707235010461 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 707235010462 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 707235010463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707235010464 putative substrate translocation pore; other site 707235010465 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707235010466 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707235010467 ligand binding site [chemical binding]; other site 707235010468 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 707235010469 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 707235010470 active site 707235010471 nucleophile elbow; other site 707235010472 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 707235010473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707235010474 FeS/SAM binding site; other site 707235010475 Methyltransferase domain; Region: Methyltransf_31; pfam13847 707235010476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235010477 S-adenosylmethionine binding site [chemical binding]; other site 707235010478 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 707235010479 nucleotide binding site [chemical binding]; other site 707235010480 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 707235010481 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 707235010482 active site 707235010483 DNA binding site [nucleotide binding] 707235010484 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 707235010485 DNA binding site [nucleotide binding] 707235010486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 707235010487 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 707235010488 nudix motif; other site 707235010489 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235010490 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235010491 Uncharacterized conserved protein [Function unknown]; Region: COG1839 707235010492 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 707235010493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 707235010494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 707235010495 Uncharacterized conserved protein [Function unknown]; Region: COG2966 707235010496 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 707235010497 Uncharacterized conserved protein [Function unknown]; Region: COG3610 707235010498 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235010499 PPE family; Region: PPE; pfam00823 707235010500 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235010501 PPE family; Region: PPE; pfam00823 707235010502 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 707235010503 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 707235010504 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235010505 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235010506 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 707235010507 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 707235010508 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707235010509 Soluble P-type ATPase [General function prediction only]; Region: COG4087 707235010510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 707235010511 dimerization interface [polypeptide binding]; other site 707235010512 putative DNA binding site [nucleotide binding]; other site 707235010513 putative Zn2+ binding site [ion binding]; other site 707235010514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 707235010515 DNA binding domain, excisionase family; Region: excise; TIGR01764 707235010516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707235010517 active site 707235010518 Int/Topo IB signature motif; other site 707235010519 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 707235010520 nucleoside/Zn binding site; other site 707235010521 dimer interface [polypeptide binding]; other site 707235010522 catalytic motif [active] 707235010523 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 707235010524 prephenate dehydrogenase; Validated; Region: PRK06545 707235010525 prephenate dehydrogenase; Validated; Region: PRK08507 707235010526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 707235010527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707235010528 ABC-ATPase subunit interface; other site 707235010529 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 707235010530 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 707235010531 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 707235010532 Walker A/P-loop; other site 707235010533 ATP binding site [chemical binding]; other site 707235010534 Q-loop/lid; other site 707235010535 ABC transporter signature motif; other site 707235010536 Walker B; other site 707235010537 D-loop; other site 707235010538 H-loop/switch region; other site 707235010539 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 707235010540 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 707235010541 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 707235010542 putative active site [active] 707235010543 putative substrate binding site [chemical binding]; other site 707235010544 ATP binding site [chemical binding]; other site 707235010545 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 707235010546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 707235010547 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 707235010548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 707235010549 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 707235010550 dimerization interface [polypeptide binding]; other site 707235010551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707235010552 dimer interface [polypeptide binding]; other site 707235010553 phosphorylation site [posttranslational modification] 707235010554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707235010555 ATP binding site [chemical binding]; other site 707235010556 Mg2+ binding site [ion binding]; other site 707235010557 G-X-G motif; other site 707235010558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707235010559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707235010560 active site 707235010561 phosphorylation site [posttranslational modification] 707235010562 intermolecular recognition site; other site 707235010563 dimerization interface [polypeptide binding]; other site 707235010564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707235010565 DNA binding site [nucleotide binding] 707235010566 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 707235010567 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235010568 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235010569 SnoaL-like domain; Region: SnoaL_2; pfam12680 707235010570 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 707235010571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707235010572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707235010573 homodimer interface [polypeptide binding]; other site 707235010574 catalytic residue [active] 707235010575 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 707235010576 TIGR03086 family protein; Region: TIGR03086 707235010577 enoyl-CoA hydratase; Provisional; Region: PRK06142 707235010578 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 707235010579 substrate binding site [chemical binding]; other site 707235010580 oxyanion hole (OAH) forming residues; other site 707235010581 trimer interface [polypeptide binding]; other site 707235010582 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 707235010583 Beta-lactamase; Region: Beta-lactamase; pfam00144 707235010584 potential protein location (hypothetical protein MTCTRI2_3854 [Mycobacterium tuberculosis CTRI-2]) that overlaps RNA (tRNA-S) 707235010585 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 707235010586 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 707235010587 NAD(P) binding site [chemical binding]; other site 707235010588 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 707235010589 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 707235010590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707235010591 catalytic residue [active] 707235010592 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 707235010593 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 707235010594 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 707235010595 Walker A/P-loop; other site 707235010596 ATP binding site [chemical binding]; other site 707235010597 Q-loop/lid; other site 707235010598 ABC transporter signature motif; other site 707235010599 Walker B; other site 707235010600 D-loop; other site 707235010601 H-loop/switch region; other site 707235010602 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 707235010603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707235010604 active site 707235010605 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 707235010606 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 707235010607 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 707235010608 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 707235010609 NAD binding site [chemical binding]; other site 707235010610 substrate binding site [chemical binding]; other site 707235010611 active site 707235010612 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 707235010613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707235010614 active site 707235010615 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 707235010616 Peptidase family M23; Region: Peptidase_M23; pfam01551 707235010617 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 707235010618 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 707235010619 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 707235010620 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 707235010621 Predicted membrane protein [Function unknown]; Region: COG2246 707235010622 GtrA-like protein; Region: GtrA; pfam04138 707235010623 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 707235010624 FAD binding domain; Region: FAD_binding_4; pfam01565 707235010625 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 707235010626 short chain dehydrogenase; Provisional; Region: PRK07904 707235010627 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 707235010628 NAD(P) binding site [chemical binding]; other site 707235010629 active site 707235010630 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 707235010631 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 707235010632 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 707235010633 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 707235010634 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 707235010635 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 707235010636 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 707235010637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 707235010638 FAD binding site [chemical binding]; other site 707235010639 substrate binding site [chemical binding]; other site 707235010640 catalytic residues [active] 707235010641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 707235010642 Transposase; Region: DDE_Tnp_ISL3; pfam01610 707235010643 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 707235010644 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 707235010645 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 707235010646 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235010647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235010648 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 707235010649 active site 707235010650 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707235010651 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235010652 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235010653 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 707235010654 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 707235010655 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235010656 acyl-activating enzyme (AAE) consensus motif; other site 707235010657 active site 707235010658 Cutinase; Region: Cutinase; pfam01083 707235010659 Predicted esterase [General function prediction only]; Region: COG0627 707235010660 Putative esterase; Region: Esterase; pfam00756 707235010661 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 707235010662 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 707235010663 active site 707235010664 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 707235010665 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707235010666 active site 707235010667 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 707235010668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235010669 UDP-galactopyranose mutase; Region: GLF; pfam03275 707235010670 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 707235010671 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 707235010672 amidase catalytic site [active] 707235010673 Zn binding residues [ion binding]; other site 707235010674 substrate binding site [chemical binding]; other site 707235010675 LGFP repeat; Region: LGFP; pfam08310 707235010676 PE family; Region: PE; pfam00934 707235010677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707235010678 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 707235010679 active site 707235010680 motif I; other site 707235010681 motif II; other site 707235010682 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 707235010683 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235010684 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235010685 putative acyl-acceptor binding pocket; other site 707235010686 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235010687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235010688 putative acyl-acceptor binding pocket; other site 707235010689 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707235010690 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707235010691 putative acyl-acceptor binding pocket; other site 707235010692 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 707235010693 Phosphotransferase enzyme family; Region: APH; pfam01636 707235010694 active site 707235010695 ATP binding site [chemical binding]; other site 707235010696 antibiotic binding site [chemical binding]; other site 707235010697 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 707235010698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 707235010699 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 707235010700 iron-sulfur cluster [ion binding]; other site 707235010701 [2Fe-2S] cluster binding site [ion binding]; other site 707235010702 Condensation domain; Region: Condensation; pfam00668 707235010703 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 707235010704 PE-PPE domain; Region: PE-PPE; pfam08237 707235010705 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 707235010706 Condensation domain; Region: Condensation; pfam00668 707235010707 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 707235010708 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 707235010709 active site 707235010710 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 707235010711 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 707235010712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 707235010713 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 707235010714 Enoylreductase; Region: PKS_ER; smart00829 707235010715 NAD(P) binding site [chemical binding]; other site 707235010716 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 707235010717 KR domain; Region: KR; pfam08659 707235010718 putative NADP binding site [chemical binding]; other site 707235010719 active site 707235010720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 707235010721 acyl-CoA synthetase; Validated; Region: PRK05850 707235010722 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 707235010723 acyl-activating enzyme (AAE) consensus motif; other site 707235010724 active site 707235010725 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 707235010726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 707235010727 Probable transposase; Region: OrfB_IS605; pfam01385 707235010728 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 707235010729 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 707235010730 catalytic residues [active] 707235010731 catalytic nucleophile [active] 707235010732 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 707235010733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235010734 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 707235010735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235010736 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 707235010737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707235010738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 707235010739 Cupin domain; Region: Cupin_2; cl17218 707235010740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 707235010741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 707235010742 seryl-tRNA synthetase; Provisional; Region: PRK05431 707235010743 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 707235010744 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 707235010745 dimer interface [polypeptide binding]; other site 707235010746 active site 707235010747 motif 1; other site 707235010748 motif 2; other site 707235010749 motif 3; other site 707235010750 Septum formation; Region: Septum_form; pfam13845 707235010751 Septum formation; Region: Septum_form; pfam13845 707235010752 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 707235010753 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707235010754 catalytic core [active] 707235010755 prephenate dehydratase; Provisional; Region: PRK11898 707235010756 Prephenate dehydratase; Region: PDT; pfam00800 707235010757 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 707235010758 putative L-Phe binding site [chemical binding]; other site 707235010759 Transcriptional regulator [Transcription]; Region: LytR; COG1316 707235010760 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 707235010761 Ferritin-like domain; Region: Ferritin; pfam00210 707235010762 ferroxidase diiron center [ion binding]; other site 707235010763 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 707235010764 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 707235010765 putative active site [active] 707235010766 catalytic site [active] 707235010767 putative metal binding site [ion binding]; other site 707235010768 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 707235010769 Transposase; Region: DEDD_Tnp_IS110; pfam01548 707235010770 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 707235010771 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 707235010772 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 707235010773 Predicted membrane protein [Function unknown]; Region: COG2119 707235010774 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 707235010775 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 707235010776 Fimbrial protein; Region: Fimbrial; cl01416 707235010777 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 707235010778 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 707235010779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 707235010780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 707235010781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 707235010782 hypothetical protein; Provisional; Region: PRK07945 707235010783 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 707235010784 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 707235010785 active site 707235010786 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 707235010787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707235010788 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 707235010789 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 707235010790 active site 707235010791 dimer interface [polypeptide binding]; other site 707235010792 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 707235010793 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 707235010794 active site 707235010795 FMN binding site [chemical binding]; other site 707235010796 substrate binding site [chemical binding]; other site 707235010797 3Fe-4S cluster binding site [ion binding]; other site 707235010798 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 707235010799 domain interface; other site 707235010800 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 707235010801 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707235010802 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 707235010803 EspG family; Region: ESX-1_EspG; pfam14011 707235010804 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 707235010805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010806 Walker A motif; other site 707235010807 ATP binding site [chemical binding]; other site 707235010808 Walker B motif; other site 707235010809 arginine finger; other site 707235010810 Protein of unknown function (DUF690); Region: DUF690; pfam05108 707235010811 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 707235010812 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010813 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 707235010814 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010815 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010816 PE family; Region: PE; pfam00934 707235010817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 707235010818 PPE family; Region: PPE; pfam00823 707235010819 Proteins of 100 residues with WXG; Region: WXG100; cl02005 707235010820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235010821 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 707235010822 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 707235010823 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 707235010824 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 707235010825 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235010826 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 707235010827 active site 707235010828 catalytic residues [active] 707235010829 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 707235010830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707235010831 Walker A motif; other site 707235010832 ATP binding site [chemical binding]; other site 707235010833 Walker B motif; other site 707235010834 arginine finger; other site 707235010835 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 707235010836 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235010837 catalytic residues [active] 707235010838 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 707235010839 active site 707235010840 catalytic residues [active] 707235010841 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 707235010842 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 707235010843 EspG family; Region: ESX-1_EspG; pfam14011 707235010844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235010845 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 707235010846 PPE family; Region: PPE; pfam00823 707235010847 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 707235010848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010849 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 707235010850 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010851 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707235010852 Protein of unknown function (DUF690); Region: DUF690; pfam05108 707235010853 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 707235010854 N-acetyl-D-glucosamine binding site [chemical binding]; other site 707235010855 catalytic residue [active] 707235010856 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 707235010857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 707235010858 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 707235010859 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 707235010860 active site 707235010861 NTP binding site [chemical binding]; other site 707235010862 metal binding triad [ion binding]; metal-binding site 707235010863 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 707235010864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 707235010865 Zn2+ binding site [ion binding]; other site 707235010866 Mg2+ binding site [ion binding]; other site 707235010867 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 707235010868 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 707235010869 active site 707235010870 Ap6A binding site [chemical binding]; other site 707235010871 nudix motif; other site 707235010872 metal binding site [ion binding]; metal-binding site 707235010873 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 707235010874 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 707235010875 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 707235010876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707235010877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707235010878 DNA binding residues [nucleotide binding] 707235010879 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 707235010880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707235010881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707235010882 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 707235010883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707235010884 catalytic residues [active] 707235010885 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 707235010886 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 707235010887 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 707235010888 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 707235010889 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 707235010890 active site 707235010891 metal binding site [ion binding]; metal-binding site 707235010892 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 707235010893 ParB-like nuclease domain; Region: ParB; smart00470 707235010894 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 707235010895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235010896 P-loop; other site 707235010897 Magnesium ion binding site [ion binding]; other site 707235010898 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 707235010899 Magnesium ion binding site [ion binding]; other site 707235010900 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 707235010901 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 707235010902 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 707235010903 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 707235010904 G-X-X-G motif; other site 707235010905 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 707235010906 RxxxH motif; other site 707235010907 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 707235010908 Uncharacterized conserved protein [Function unknown]; Region: COG0759 707235010909 ribonuclease P; Reviewed; Region: rnpA; PRK00588 707235010910 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399