-- dump date 20140619_153941 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443149000001 potential frameshift: common BLAST hit: gi|378769744|ref|YP_005169477.1| chromosomal replication initiator protein DnaA 443149000002 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 443149000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000004 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443149000005 Walker A motif; other site 443149000006 ATP binding site [chemical binding]; other site 443149000007 Walker B motif; other site 443149000008 arginine finger; other site 443149000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443149000010 DnaA box-binding interface [nucleotide binding]; other site 443149000011 DNA polymerase III subunit beta; Validated; Region: PRK07761 443149000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443149000013 putative DNA binding surface [nucleotide binding]; other site 443149000014 dimer interface [polypeptide binding]; other site 443149000015 beta-clamp/clamp loader binding surface; other site 443149000016 beta-clamp/translesion DNA polymerase binding surface; other site 443149000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000018 Q-loop/lid; other site 443149000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000020 ABC transporter signature motif; other site 443149000021 Walker B; other site 443149000022 D-loop; other site 443149000023 H-loop/switch region; other site 443149000024 hypothetical protein; Provisional; Region: PRK03195 443149000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443149000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149000027 Mg2+ binding site [ion binding]; other site 443149000028 G-X-G motif; other site 443149000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443149000030 anchoring element; other site 443149000031 dimer interface [polypeptide binding]; other site 443149000032 ATP binding site [chemical binding]; other site 443149000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443149000034 active site 443149000035 putative metal-binding site [ion binding]; other site 443149000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443149000037 DNA gyrase subunit A; Validated; Region: PRK05560 443149000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443149000039 CAP-like domain; other site 443149000040 active site 443149000041 primary dimer interface [polypeptide binding]; other site 443149000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443149000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443149000049 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 443149000050 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443149000051 active site 443149000052 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149000053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149000054 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149000055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443149000056 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443149000057 glutamine binding [chemical binding]; other site 443149000058 catalytic triad [active] 443149000059 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149000060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149000061 active site 443149000062 ATP binding site [chemical binding]; other site 443149000063 substrate binding site [chemical binding]; other site 443149000064 activation loop (A-loop); other site 443149000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 443149000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149000070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149000071 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149000072 active site 443149000073 ATP binding site [chemical binding]; other site 443149000074 substrate binding site [chemical binding]; other site 443149000075 activation loop (A-loop); other site 443149000076 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149000077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149000078 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 443149000079 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443149000080 active site 443149000081 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149000082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149000083 phosphopeptide binding site; other site 443149000084 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443149000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149000086 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149000087 phosphopeptide binding site; other site 443149000088 Nitronate monooxygenase; Region: NMO; pfam03060 443149000089 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149000090 FMN binding site [chemical binding]; other site 443149000091 substrate binding site [chemical binding]; other site 443149000092 putative catalytic residue [active] 443149000093 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149000094 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149000095 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149000096 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149000097 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149000098 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 443149000099 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 443149000100 potential frameshift: common BLAST hit: gi|383305971|ref|YP_005358782.1| 8-amino-7-oxononanoate synthase 443149000101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 443149000102 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 443149000103 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 443149000104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149000105 catalytic residue [active] 443149000106 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443149000107 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443149000108 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149000109 acyl-activating enzyme (AAE) consensus motif; other site 443149000110 active site 443149000111 TIGR03084 family protein; Region: TIGR03084 443149000112 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149000113 Wyosine base formation; Region: Wyosine_form; pfam08608 443149000114 H+ Antiporter protein; Region: 2A0121; TIGR00900 443149000115 hypothetical protein; Validated; Region: PRK00228 443149000116 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149000117 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443149000118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000119 active site 443149000120 HIGH motif; other site 443149000121 nucleotide binding site [chemical binding]; other site 443149000122 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443149000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000124 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149000125 active site 443149000126 KMSKS motif; other site 443149000127 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443149000128 tRNA binding surface [nucleotide binding]; other site 443149000129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149000130 MarR family; Region: MarR; pfam01047 443149000131 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149000132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149000133 DNA-binding site [nucleotide binding]; DNA binding site 443149000134 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 443149000135 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149000136 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149000137 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 443149000138 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 443149000139 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149000140 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149000141 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149000142 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443149000143 Transglycosylase; Region: Transgly; pfam00912 443149000144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149000145 Predicted integral membrane protein [Function unknown]; Region: COG5650 443149000146 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443149000147 conserved cys residue [active] 443149000148 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443149000149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443149000150 dimer interface [polypeptide binding]; other site 443149000151 ssDNA binding site [nucleotide binding]; other site 443149000152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443149000153 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443149000154 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443149000155 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443149000156 replicative DNA helicase; Validated; Region: PRK07773 443149000157 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443149000158 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443149000159 Walker A motif; other site 443149000160 ATP binding site [chemical binding]; other site 443149000161 Walker B motif; other site 443149000162 DNA binding loops [nucleotide binding] 443149000163 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149000164 protein-splicing catalytic site; other site 443149000165 thioester formation/cholesterol transfer; other site 443149000166 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149000167 protein-splicing catalytic site; other site 443149000168 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149000169 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 443149000170 ADP-ribose binding site [chemical binding]; other site 443149000171 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 443149000172 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 443149000173 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149000174 FAD binding domain; Region: FAD_binding_4; pfam01565 443149000175 Berberine and berberine like; Region: BBE; pfam08031 443149000176 hypothetical protein; Provisional; Region: PRK12438 443149000177 hypothetical protein; Validated; Region: PRK00068 443149000178 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149000179 homotetrameric interface [polypeptide binding]; other site 443149000180 putative active site [active] 443149000181 metal binding site [ion binding]; metal-binding site 443149000182 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 443149000183 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 443149000184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000186 short chain dehydrogenase; Provisional; Region: PRK06197 443149000187 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443149000188 putative NAD(P) binding site [chemical binding]; other site 443149000189 active site 443149000190 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443149000191 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443149000192 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 443149000193 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443149000194 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443149000195 dimer interface [polypeptide binding]; other site 443149000196 active site 443149000197 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443149000198 folate binding site [chemical binding]; other site 443149000199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149000200 active site 443149000201 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443149000202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149000203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149000204 homodimer interface [polypeptide binding]; other site 443149000205 catalytic residue [active] 443149000206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000209 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443149000210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149000211 dimerization interface [polypeptide binding]; other site 443149000212 putative DNA binding site [nucleotide binding]; other site 443149000213 putative Zn2+ binding site [ion binding]; other site 443149000214 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 443149000215 hydrogenase 4 subunit B; Validated; Region: PRK06521 443149000216 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149000217 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443149000218 NADH dehydrogenase; Region: NADHdh; cl00469 443149000219 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 443149000220 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149000221 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 443149000222 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 443149000223 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 443149000224 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 443149000225 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 443149000226 putative hydrophobic ligand binding site [chemical binding]; other site 443149000227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000228 S-adenosylmethionine binding site [chemical binding]; other site 443149000229 Predicted membrane protein [Function unknown]; Region: COG3305 443149000230 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443149000231 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 443149000232 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149000233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000234 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149000235 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149000236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149000237 active site 443149000238 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000239 PPE family; Region: PPE; pfam00823 443149000240 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443149000241 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 443149000242 FcoT-like thioesterase domain; Region: FcoT; pfam10862 443149000243 acyl-CoA synthetase; Validated; Region: PRK05857 443149000244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000245 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 443149000246 acyl-activating enzyme (AAE) consensus motif; other site 443149000247 acyl-activating enzyme (AAE) consensus motif; other site 443149000248 AMP binding site [chemical binding]; other site 443149000249 active site 443149000250 CoA binding site [chemical binding]; other site 443149000251 AMP-binding enzyme; Region: AMP-binding; pfam00501 443149000252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000253 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000254 acyl-activating enzyme (AAE) consensus motif; other site 443149000255 acyl-activating enzyme (AAE) consensus motif; other site 443149000256 active site 443149000257 AMP binding site [chemical binding]; other site 443149000258 CoA binding site [chemical binding]; other site 443149000259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149000260 Condensation domain; Region: Condensation; pfam00668 443149000261 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149000262 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149000263 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149000264 acyl-activating enzyme (AAE) consensus motif; other site 443149000265 AMP binding site [chemical binding]; other site 443149000266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149000267 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443149000268 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443149000269 putative NAD(P) binding site [chemical binding]; other site 443149000270 active site 443149000271 putative substrate binding site [chemical binding]; other site 443149000272 Predicted membrane protein [Function unknown]; Region: COG3336 443149000273 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149000274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443149000275 metal-binding site [ion binding] 443149000276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000277 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149000278 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 443149000279 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443149000280 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443149000281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149000282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149000283 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443149000284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149000285 motif II; other site 443149000286 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149000287 PE family; Region: PE; pfam00934 443149000288 Rhomboid family; Region: Rhomboid; pfam01694 443149000289 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149000290 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443149000291 active site 443149000292 catalytic triad [active] 443149000293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149000294 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443149000295 NADP-binding site; other site 443149000296 homotetramer interface [polypeptide binding]; other site 443149000297 substrate binding site [chemical binding]; other site 443149000298 homodimer interface [polypeptide binding]; other site 443149000299 active site 443149000300 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443149000301 dimer interface [polypeptide binding]; other site 443149000302 active site 443149000303 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 443149000304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149000305 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149000306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149000307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149000308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149000309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443149000310 dimerization interface [polypeptide binding]; other site 443149000311 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 443149000312 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149000313 PYR/PP interface [polypeptide binding]; other site 443149000314 dimer interface [polypeptide binding]; other site 443149000315 TPP binding site [chemical binding]; other site 443149000316 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149000317 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443149000318 TPP-binding site; other site 443149000319 dimer interface [polypeptide binding]; other site 443149000320 acyl-CoA synthetase; Validated; Region: PRK05852 443149000321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000322 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 443149000323 acyl-activating enzyme (AAE) consensus motif; other site 443149000324 acyl-activating enzyme (AAE) consensus motif; other site 443149000325 putative AMP binding site [chemical binding]; other site 443149000326 putative active site [active] 443149000327 putative CoA binding site [chemical binding]; other site 443149000328 potential frameshift: common BLAST hit: gi|383306052|ref|YP_005358863.1| elongation factor G 443149000329 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443149000330 elongation factor G; Reviewed; Region: PRK12740 443149000331 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443149000332 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443149000333 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 443149000334 G1 box; other site 443149000335 putative GEF interaction site [polypeptide binding]; other site 443149000336 GTP/Mg2+ binding site [chemical binding]; other site 443149000337 Switch I region; other site 443149000338 G2 box; other site 443149000339 G3 box; other site 443149000340 Switch II region; other site 443149000341 G4 box; other site 443149000342 G5 box; other site 443149000343 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 443149000344 PE family; Region: PE; pfam00934 443149000345 potential frameshift: common BLAST hit: gi|253797044|ref|YP_003030045.1| serine protease pepA 443149000346 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149000347 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149000348 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149000349 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149000350 trehalose synthase; Region: treS_nterm; TIGR02456 443149000351 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443149000352 active site 443149000353 catalytic site [active] 443149000354 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 443149000355 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443149000356 Predicted membrane protein [Function unknown]; Region: COG3619 443149000357 Predicted esterase [General function prediction only]; Region: COG0627 443149000358 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443149000359 putative active site [active] 443149000360 putative catalytic site [active] 443149000361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000363 active site 443149000364 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443149000365 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149000366 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 443149000367 Coenzyme A binding pocket [chemical binding]; other site 443149000368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000371 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149000372 Cytochrome P450; Region: p450; cl12078 443149000373 methionine sulfoxide reductase A; Provisional; Region: PRK14054 443149000374 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000375 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443149000376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149000377 NAD(P) binding site [chemical binding]; other site 443149000378 active site 443149000379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149000380 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 443149000381 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443149000382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149000383 minor groove reading motif; other site 443149000384 helix-hairpin-helix signature motif; other site 443149000385 active site 443149000386 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 443149000387 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 443149000388 Cl- selectivity filter; other site 443149000389 Cl- binding residues [ion binding]; other site 443149000390 pore gating glutamate residue; other site 443149000391 dimer interface [polypeptide binding]; other site 443149000392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000394 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000395 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000396 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000397 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000398 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 443149000399 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 443149000400 NAD(P) binding site [chemical binding]; other site 443149000401 catalytic residues [active] 443149000402 short chain dehydrogenase; Provisional; Region: PRK07791 443149000403 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443149000404 NAD binding site [chemical binding]; other site 443149000405 homodimer interface [polypeptide binding]; other site 443149000406 active site 443149000407 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149000408 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443149000409 NAD(P) binding site [chemical binding]; other site 443149000410 PE family; Region: PE; pfam00934 443149000411 PE-PPE domain; Region: PE-PPE; pfam08237 443149000412 PE-PPE domain; Region: PE-PPE; pfam08237 443149000413 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 443149000414 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 443149000415 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443149000416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000417 active site 443149000418 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443149000419 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 443149000420 ligand binding site [chemical binding]; other site 443149000421 homodimer interface [polypeptide binding]; other site 443149000422 NAD(P) binding site [chemical binding]; other site 443149000423 trimer interface B [polypeptide binding]; other site 443149000424 trimer interface A [polypeptide binding]; other site 443149000425 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 443149000426 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 443149000427 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 443149000428 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 443149000429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000431 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 443149000432 PE family; Region: PE; pfam00934 443149000433 PE-PPE domain; Region: PE-PPE; pfam08237 443149000434 PE family; Region: PE; pfam00934 443149000435 PE-PPE domain; Region: PE-PPE; pfam08237 443149000436 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149000437 FAD binding domain; Region: FAD_binding_4; pfam01565 443149000438 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443149000439 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149000440 NAD(P) binding site [chemical binding]; other site 443149000441 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149000442 active site 443149000443 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149000444 putative hydrophobic ligand binding site [chemical binding]; other site 443149000445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443149000446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149000447 DNA-binding site [nucleotide binding]; DNA binding site 443149000448 FCD domain; Region: FCD; pfam07729 443149000449 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 443149000450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000451 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149000452 acyl-activating enzyme (AAE) consensus motif; other site 443149000453 acyl-activating enzyme (AAE) consensus motif; other site 443149000454 putative AMP binding site [chemical binding]; other site 443149000455 putative active site [active] 443149000456 putative CoA binding site [chemical binding]; other site 443149000457 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149000458 Permease; Region: Permease; pfam02405 443149000459 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149000460 Permease; Region: Permease; pfam02405 443149000461 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000462 mce related protein; Region: MCE; pfam02470 443149000463 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149000464 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000465 mce related protein; Region: MCE; pfam02470 443149000466 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149000467 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000468 mce related protein; Region: MCE; pfam02470 443149000469 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000470 mce related protein; Region: MCE; pfam02470 443149000471 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000472 mce related protein; Region: MCE; pfam02470 443149000473 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149000474 mce related protein; Region: MCE; pfam02470 443149000475 RDD family; Region: RDD; pfam06271 443149000476 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 443149000477 Predicted membrane protein [Function unknown]; Region: COG1511 443149000478 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443149000479 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443149000480 Pirin-related protein [General function prediction only]; Region: COG1741 443149000481 Pirin; Region: Pirin; pfam02678 443149000482 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443149000483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149000484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149000485 DNA binding residues [nucleotide binding] 443149000486 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000487 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443149000488 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149000489 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 443149000490 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 443149000491 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443149000492 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443149000493 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443149000494 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443149000495 SPW repeat; Region: SPW; pfam03779 443149000496 SPW repeat; Region: SPW; pfam03779 443149000497 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443149000498 6-phosphogluconate dehydratase; Region: edd; TIGR01196 443149000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149000500 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443149000501 putative substrate translocation pore; other site 443149000502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149000503 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149000504 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149000505 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149000506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149000507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000508 Walker A/P-loop; other site 443149000509 ATP binding site [chemical binding]; other site 443149000510 Q-loop/lid; other site 443149000511 ABC transporter signature motif; other site 443149000512 Walker B; other site 443149000513 D-loop; other site 443149000514 H-loop/switch region; other site 443149000515 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149000516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149000517 Walker A/P-loop; other site 443149000518 ATP binding site [chemical binding]; other site 443149000519 Q-loop/lid; other site 443149000520 ABC transporter signature motif; other site 443149000521 Walker B; other site 443149000522 D-loop; other site 443149000523 H-loop/switch region; other site 443149000524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149000525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149000526 dimerization interface [polypeptide binding]; other site 443149000527 DNA binding residues [nucleotide binding] 443149000528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000530 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443149000531 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443149000532 putative [Fe4-S4] binding site [ion binding]; other site 443149000533 putative molybdopterin cofactor binding site [chemical binding]; other site 443149000534 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149000535 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443149000536 putative molybdopterin cofactor binding site; other site 443149000537 potential frameshift: common BLAST hit: gi|378769943|ref|YP_005169676.1| putative zinc metalloprotease 443149000538 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 443149000539 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443149000540 active site 443149000541 Zn binding site [ion binding]; other site 443149000542 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149000543 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 443149000544 Predicted integral membrane protein [Function unknown]; Region: COG0392 443149000545 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443149000546 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443149000547 MMPL family; Region: MMPL; pfam03176 443149000548 MMPL family; Region: MMPL; pfam03176 443149000549 LabA_like proteins; Region: LabA_like; cd06167 443149000550 putative metal binding site [ion binding]; other site 443149000551 Putative methyltransferase; Region: Methyltransf_4; pfam02390 443149000552 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443149000553 active site 443149000554 substrate-binding site [chemical binding]; other site 443149000555 metal-binding site [ion binding] 443149000556 GTP binding site [chemical binding]; other site 443149000557 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 443149000558 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 443149000559 active site 443149000560 (T/H)XGH motif; other site 443149000561 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 443149000562 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 443149000563 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 443149000564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149000565 FeS/SAM binding site; other site 443149000566 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 443149000567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000568 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149000569 acyl-activating enzyme (AAE) consensus motif; other site 443149000570 acyl-activating enzyme (AAE) consensus motif; other site 443149000571 putative AMP binding site [chemical binding]; other site 443149000572 putative active site [active] 443149000573 putative CoA binding site [chemical binding]; other site 443149000574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000575 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000576 active site 443149000577 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443149000578 putative active site [active] 443149000579 putative catalytic site [active] 443149000580 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149000581 active site 2 [active] 443149000582 active site 1 [active] 443149000583 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149000584 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149000585 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443149000586 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 443149000587 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443149000588 Moco binding site; other site 443149000589 metal coordination site [ion binding]; other site 443149000590 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149000591 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149000592 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149000593 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149000594 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149000595 enoyl-CoA hydratase; Provisional; Region: PRK08252 443149000596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149000597 substrate binding site [chemical binding]; other site 443149000598 oxyanion hole (OAH) forming residues; other site 443149000599 trimer interface [polypeptide binding]; other site 443149000600 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 443149000601 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149000602 NAD binding site [chemical binding]; other site 443149000603 catalytic residues [active] 443149000604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000605 S-adenosylmethionine binding site [chemical binding]; other site 443149000606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149000607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149000608 potential frameshift: common BLAST hit: gi|378769971|ref|YP_005169704.1| transmembrane protein 443149000609 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 443149000610 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149000611 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 443149000612 active site 443149000613 substrate binding pocket [chemical binding]; other site 443149000614 homodimer interaction site [polypeptide binding]; other site 443149000615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000616 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149000617 active site 443149000618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000620 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 443149000621 active site 443149000622 diiron metal binding site [ion binding]; other site 443149000623 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443149000624 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 443149000625 NAD(P) binding site [chemical binding]; other site 443149000626 catalytic residues [active] 443149000627 Lipase maturation factor; Region: LMF1; pfam06762 443149000628 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 443149000629 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443149000630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443149000631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000633 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149000634 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149000635 MaoC like domain; Region: MaoC_dehydratas; pfam01575 443149000636 active site 2 [active] 443149000637 active site 1 [active] 443149000638 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 443149000639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149000640 NAD(P) binding site [chemical binding]; other site 443149000641 active site 443149000642 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 443149000643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149000644 dimer interface [polypeptide binding]; other site 443149000645 active site 443149000646 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443149000647 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443149000648 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 443149000649 FAD binding site [chemical binding]; other site 443149000650 substrate binding site [chemical binding]; other site 443149000651 catalytic residues [active] 443149000652 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443149000653 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149000654 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 443149000655 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149000656 catalytic loop [active] 443149000657 iron binding site [ion binding]; other site 443149000658 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 443149000659 L-aspartate oxidase; Provisional; Region: PRK06175 443149000660 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149000661 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443149000662 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443149000663 putative dimer interface [polypeptide binding]; other site 443149000664 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 443149000665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149000666 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 443149000667 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149000668 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 443149000669 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443149000670 homotrimer interface [polypeptide binding]; other site 443149000671 Walker A motif; other site 443149000672 GTP binding site [chemical binding]; other site 443149000673 Walker B motif; other site 443149000674 cobyric acid synthase; Provisional; Region: PRK00784 443149000675 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 443149000676 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443149000677 catalytic triad [active] 443149000678 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000679 PPE family; Region: PPE; pfam00823 443149000680 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443149000681 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443149000682 putative active site [active] 443149000683 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443149000684 putative active site [active] 443149000685 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 443149000686 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443149000687 active site 443149000688 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 443149000689 DNA binding site [nucleotide binding] 443149000690 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149000691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149000692 Coenzyme A binding pocket [chemical binding]; other site 443149000693 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 443149000694 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 443149000695 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 443149000696 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443149000697 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443149000698 intersubunit interface [polypeptide binding]; other site 443149000699 5-oxoprolinase; Region: PLN02666 443149000700 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 443149000701 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 443149000702 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 443149000703 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149000704 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443149000705 nucleotide binding site [chemical binding]; other site 443149000706 acyl-CoA synthetase; Validated; Region: PRK07788 443149000707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149000709 active site 443149000710 CoA binding site [chemical binding]; other site 443149000711 AMP binding site [chemical binding]; other site 443149000712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149000714 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149000715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149000716 FAD binding site [chemical binding]; other site 443149000717 substrate binding site [chemical binding]; other site 443149000718 catalytic base [active] 443149000719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149000723 PE family; Region: PE; pfam00934 443149000724 PE family; Region: PE; pfam00934 443149000725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000726 PPE family; Region: PPE; pfam00823 443149000727 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000728 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149000729 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149000730 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149000731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000732 Walker A motif; other site 443149000733 ATP binding site [chemical binding]; other site 443149000734 Walker B motif; other site 443149000735 arginine finger; other site 443149000736 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149000737 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149000738 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000739 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149000740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000741 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149000742 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000743 PPE family; Region: PPE; pfam00823 443149000744 EspG family; Region: ESX-1_EspG; pfam14011 443149000745 potential frameshift: common BLAST hit: gi|148821488|ref|YP_001286242.1| transmembrane protein 443149000746 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 443149000747 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 443149000748 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149000749 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149000750 active site 443149000751 catalytic residues [active] 443149000752 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149000753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149000754 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 443149000755 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 443149000756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000757 S-adenosylmethionine binding site [chemical binding]; other site 443149000758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 443149000759 Sulfatase; Region: Sulfatase; cl17466 443149000760 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149000761 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149000762 putative active site [active] 443149000763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000765 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 443149000766 protochlorophyllide reductase; Region: PLN00015 443149000767 putative NAD(P) binding site [chemical binding]; other site 443149000768 active site 443149000769 potential frameshift: common BLAST hit: gi|375294513|ref|YP_005098780.1| PPE family protein 443149000770 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000771 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000772 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000773 potential frameshift: common BLAST hit: gi|375294513|ref|YP_005098780.1| PPE family protein 443149000774 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000775 PPE family; Region: PPE; pfam00823 443149000776 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000777 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000778 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000779 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000780 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000781 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000782 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000783 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000784 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 443149000785 putative FMN binding site [chemical binding]; other site 443149000786 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443149000787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443149000788 active site 443149000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 443149000790 SnoaL-like domain; Region: SnoaL_4; pfam13577 443149000791 SnoaL-like domain; Region: SnoaL_3; pfam13474 443149000792 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443149000793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149000794 nucleotide binding site [chemical binding]; other site 443149000795 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 443149000796 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149000797 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 443149000798 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 443149000799 active site 443149000800 catalytic residues [active] 443149000801 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 443149000802 Muconolactone delta-isomerase; Region: MIase; cl01992 443149000803 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 443149000804 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149000805 putative active site [active] 443149000806 putative metal binding site [ion binding]; other site 443149000807 catalytic site [active] 443149000808 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 443149000809 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 443149000810 putative substrate binding pocket [chemical binding]; other site 443149000811 AC domain interface; other site 443149000812 catalytic triad [active] 443149000813 AB domain interface; other site 443149000814 interchain disulfide; other site 443149000815 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443149000816 trimer interface [polypeptide binding]; other site 443149000817 active site 443149000818 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443149000819 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149000820 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443149000821 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443149000822 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 443149000823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149000824 dimerization interface [polypeptide binding]; other site 443149000825 putative DNA binding site [nucleotide binding]; other site 443149000826 putative Zn2+ binding site [ion binding]; other site 443149000827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149000828 active site residue [active] 443149000829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000830 S-adenosylmethionine binding site [chemical binding]; other site 443149000831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149000832 Cytochrome P450; Region: p450; cl12078 443149000833 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443149000834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000835 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443149000836 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149000837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149000838 S-adenosylmethionine binding site [chemical binding]; other site 443149000839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149000840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149000841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443149000842 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149000843 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149000844 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149000845 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443149000846 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443149000847 substrate binding site; other site 443149000848 tetramer interface; other site 443149000849 PE family; Region: PE; pfam00934 443149000850 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149000851 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149000852 active site 443149000853 aminotransferase AlaT; Validated; Region: PRK09265 443149000854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149000855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149000856 homodimer interface [polypeptide binding]; other site 443149000857 catalytic residue [active] 443149000858 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443149000859 4Fe-4S binding domain; Region: Fer4; pfam00037 443149000860 Cysteine-rich domain; Region: CCG; pfam02754 443149000861 Cysteine-rich domain; Region: CCG; pfam02754 443149000862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149000863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149000864 DNA binding residues [nucleotide binding] 443149000865 dimerization interface [polypeptide binding]; other site 443149000866 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443149000867 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149000868 G1 box; other site 443149000869 GTP/Mg2+ binding site [chemical binding]; other site 443149000870 G2 box; other site 443149000871 Switch I region; other site 443149000872 G3 box; other site 443149000873 Switch II region; other site 443149000874 G4 box; other site 443149000875 G5 box; other site 443149000876 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 443149000877 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149000878 G1 box; other site 443149000879 GTP/Mg2+ binding site [chemical binding]; other site 443149000880 G2 box; other site 443149000881 Switch I region; other site 443149000882 G3 box; other site 443149000883 Switch II region; other site 443149000884 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 443149000885 active site 443149000886 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149000887 TIGR04255 family protein; Region: sporadTIGR04255 443149000888 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443149000889 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 443149000890 nucleotide binding site [chemical binding]; other site 443149000891 NEF interaction site [polypeptide binding]; other site 443149000892 SBD interface [polypeptide binding]; other site 443149000893 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 443149000894 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443149000895 dimer interface [polypeptide binding]; other site 443149000896 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443149000897 chaperone protein DnaJ; Provisional; Region: PRK14279 443149000898 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443149000899 HSP70 interaction site [polypeptide binding]; other site 443149000900 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443149000901 Zn binding sites [ion binding]; other site 443149000902 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443149000903 dimer interface [polypeptide binding]; other site 443149000904 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 443149000905 DNA binding residues [nucleotide binding] 443149000906 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149000907 putative dimer interface [polypeptide binding]; other site 443149000908 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000909 PPE family; Region: PPE; pfam00823 443149000910 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000911 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000912 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000913 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149000914 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149000915 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149000916 CoenzymeA binding site [chemical binding]; other site 443149000917 subunit interaction site [polypeptide binding]; other site 443149000918 PHB binding site; other site 443149000919 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443149000920 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443149000921 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 443149000922 Peptidase family M50; Region: Peptidase_M50; pfam02163 443149000923 active site 443149000924 putative substrate binding region [chemical binding]; other site 443149000925 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443149000926 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443149000927 MgtE intracellular N domain; Region: MgtE_N; pfam03448 443149000928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443149000929 Divalent cation transporter; Region: MgtE; pfam01769 443149000930 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443149000931 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 443149000932 active site 443149000933 intersubunit interface [polypeptide binding]; other site 443149000934 zinc binding site [ion binding]; other site 443149000935 Na+ binding site [ion binding]; other site 443149000936 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443149000937 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443149000938 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 443149000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 443149000940 AAA domain; Region: AAA_33; pfam13671 443149000941 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 443149000942 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443149000943 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443149000944 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 443149000945 putative hydrophobic ligand binding site [chemical binding]; other site 443149000946 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149000947 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443149000948 Ligand binding site; other site 443149000949 metal-binding site 443149000950 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443149000951 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149000952 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443149000953 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 443149000954 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 443149000955 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443149000956 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 443149000957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149000958 catalytic loop [active] 443149000959 iron binding site [ion binding]; other site 443149000960 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443149000961 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 443149000962 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 443149000963 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149000964 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 443149000965 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443149000966 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443149000967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149000968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149000969 LysR substrate binding domain; Region: LysR_substrate; pfam03466 443149000970 dimerization interface [polypeptide binding]; other site 443149000971 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149000972 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149000973 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149000974 active site 443149000975 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443149000976 Clp amino terminal domain; Region: Clp_N; pfam02861 443149000977 Clp amino terminal domain; Region: Clp_N; pfam02861 443149000978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000979 Walker A motif; other site 443149000980 ATP binding site [chemical binding]; other site 443149000981 Walker B motif; other site 443149000982 arginine finger; other site 443149000983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149000984 Walker A motif; other site 443149000985 ATP binding site [chemical binding]; other site 443149000986 Walker B motif; other site 443149000987 arginine finger; other site 443149000988 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443149000989 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 443149000990 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 443149000991 heme-binding site [chemical binding]; other site 443149000992 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 443149000993 FAD binding pocket [chemical binding]; other site 443149000994 FAD binding motif [chemical binding]; other site 443149000995 phosphate binding motif [ion binding]; other site 443149000996 beta-alpha-beta structure motif; other site 443149000997 NAD binding pocket [chemical binding]; other site 443149000998 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149000999 cyclase homology domain; Region: CHD; cd07302 443149001000 nucleotidyl binding site; other site 443149001001 metal binding site [ion binding]; metal-binding site 443149001002 dimer interface [polypeptide binding]; other site 443149001003 Predicted ATPase [General function prediction only]; Region: COG3903 443149001004 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149001005 Walker A motif; other site 443149001006 ATP binding site [chemical binding]; other site 443149001007 Walker B motif; other site 443149001008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149001009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149001010 DNA binding residues [nucleotide binding] 443149001011 PPE family; Region: PPE; pfam00823 443149001012 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001013 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 443149001014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149001015 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 443149001016 active site residue [active] 443149001017 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 443149001018 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149001019 homodimer interface [polypeptide binding]; other site 443149001020 substrate-cofactor binding pocket; other site 443149001021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149001022 catalytic residue [active] 443149001023 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443149001024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149001025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001026 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149001027 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149001028 active site 443149001029 PLD-like domain; Region: PLDc_2; pfam13091 443149001030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149001031 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149001032 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 443149001033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149001034 FAD binding site [chemical binding]; other site 443149001035 substrate binding pocket [chemical binding]; other site 443149001036 catalytic base [active] 443149001037 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443149001038 potential frameshift: common BLAST hit: gi|375294607|ref|YP_005098874.1| transmembrane transporter mmpL1 443149001039 MMPL family; Region: MMPL; pfam03176 443149001040 MMPL family; Region: MMPL; pfam03176 443149001041 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001042 acyl-CoA synthetase; Validated; Region: PRK05850 443149001043 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149001044 acyl-activating enzyme (AAE) consensus motif; other site 443149001045 active site 443149001046 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149001047 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149001048 active site 443149001049 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149001050 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149001051 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149001052 Thioesterase; Region: PKS_TE; smart00824 443149001053 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 443149001054 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443149001055 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149001056 phosphate acetyltransferase; Reviewed; Region: PRK05632 443149001057 DRTGG domain; Region: DRTGG; pfam07085 443149001058 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443149001059 propionate/acetate kinase; Provisional; Region: PRK12379 443149001060 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443149001061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149001062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149001063 active site 443149001064 ATP binding site [chemical binding]; other site 443149001065 substrate binding site [chemical binding]; other site 443149001066 activation loop (A-loop); other site 443149001067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443149001068 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443149001069 substrate binding pocket [chemical binding]; other site 443149001070 membrane-bound complex binding site; other site 443149001071 hinge residues; other site 443149001072 NUDIX domain; Region: NUDIX; pfam00293 443149001073 nudix motif; other site 443149001074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443149001075 thiamine phosphate binding site [chemical binding]; other site 443149001076 active site 443149001077 pyrophosphate binding site [ion binding]; other site 443149001078 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443149001079 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443149001080 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443149001081 ThiS interaction site; other site 443149001082 putative active site [active] 443149001083 tetramer interface [polypeptide binding]; other site 443149001084 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443149001085 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443149001086 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 443149001087 PA/protease or protease-like domain interface [polypeptide binding]; other site 443149001088 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 443149001089 active site 443149001090 metal binding site [ion binding]; metal-binding site 443149001091 Predicted metalloprotease [General function prediction only]; Region: COG2321 443149001092 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 443149001093 Zn binding site [ion binding]; other site 443149001094 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149001095 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443149001096 dimer interface [polypeptide binding]; other site 443149001097 substrate binding site [chemical binding]; other site 443149001098 ATP binding site [chemical binding]; other site 443149001099 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 443149001100 ThiC-associated domain; Region: ThiC-associated; pfam13667 443149001101 ThiC family; Region: ThiC; pfam01964 443149001102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149001103 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 443149001104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149001105 motif II; other site 443149001106 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149001107 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443149001108 putative catalytic site [active] 443149001109 putative phosphate binding site [ion binding]; other site 443149001110 active site 443149001111 metal binding site A [ion binding]; metal-binding site 443149001112 DNA binding site [nucleotide binding] 443149001113 putative AP binding site [nucleotide binding]; other site 443149001114 putative metal binding site B [ion binding]; other site 443149001115 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443149001116 active site 443149001117 catalytic residues [active] 443149001118 metal binding site [ion binding]; metal-binding site 443149001119 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149001120 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 443149001121 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443149001122 E-class dimer interface [polypeptide binding]; other site 443149001123 P-class dimer interface [polypeptide binding]; other site 443149001124 active site 443149001125 Cu2+ binding site [ion binding]; other site 443149001126 Zn2+ binding site [ion binding]; other site 443149001127 carboxylate-amine ligase; Provisional; Region: PRK13517 443149001128 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443149001129 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 443149001130 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 443149001131 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 443149001132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001133 Walker A motif; other site 443149001134 ATP binding site [chemical binding]; other site 443149001135 Walker B motif; other site 443149001136 arginine finger; other site 443149001137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149001138 Walker A motif; other site 443149001139 ATP binding site [chemical binding]; other site 443149001140 Walker B motif; other site 443149001141 arginine finger; other site 443149001142 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443149001143 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443149001144 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 443149001145 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443149001146 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443149001147 dimer interface [polypeptide binding]; other site 443149001148 putative functional site; other site 443149001149 putative MPT binding site; other site 443149001150 short chain dehydrogenase; Provisional; Region: PRK06197 443149001151 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443149001152 putative NAD(P) binding site [chemical binding]; other site 443149001153 active site 443149001154 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443149001155 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443149001156 ring oligomerisation interface [polypeptide binding]; other site 443149001157 ATP/Mg binding site [chemical binding]; other site 443149001158 stacking interactions; other site 443149001159 hinge regions; other site 443149001160 potential frameshift: common BLAST hit: gi|383306357|ref|YP_005359168.1| PPE family protein 443149001161 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001162 PPE family; Region: PPE; pfam00823 443149001163 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443149001164 DinB superfamily; Region: DinB_2; pfam12867 443149001165 putative anti-sigmaE protein; Provisional; Region: PRK13920 443149001166 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443149001167 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443149001168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149001169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149001170 DNA binding residues [nucleotide binding] 443149001171 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 443149001172 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001174 S-adenosylmethionine binding site [chemical binding]; other site 443149001175 Uncharacterized conserved protein [Function unknown]; Region: COG3496 443149001176 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443149001177 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 443149001178 dimer interface [polypeptide binding]; other site 443149001179 Transport protein; Region: actII; TIGR00833 443149001180 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001182 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001183 PPE family; Region: PPE; pfam00823 443149001184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001185 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 443149001186 enoyl-CoA hydratase; Provisional; Region: PRK12478 443149001187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001188 substrate binding site [chemical binding]; other site 443149001189 oxyanion hole (OAH) forming residues; other site 443149001190 trimer interface [polypeptide binding]; other site 443149001191 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443149001192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149001193 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 443149001194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149001195 NAD(P) binding site [chemical binding]; other site 443149001196 catalytic residues [active] 443149001197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 443149001198 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 443149001199 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 443149001200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001201 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149001202 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149001203 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443149001204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149001205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149001206 non-specific DNA binding site [nucleotide binding]; other site 443149001207 salt bridge; other site 443149001208 sequence-specific DNA binding site [nucleotide binding]; other site 443149001209 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443149001210 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443149001211 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443149001212 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443149001213 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149001214 active site 443149001215 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149001216 active site 2 [active] 443149001217 isocitrate lyase; Provisional; Region: PRK15063 443149001218 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 443149001219 oligomerization interface [polypeptide binding]; other site 443149001220 active site 443149001221 metal binding site [ion binding]; metal-binding site 443149001222 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443149001223 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149001224 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149001225 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001227 S-adenosylmethionine binding site [chemical binding]; other site 443149001228 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001231 S-adenosylmethionine binding site [chemical binding]; other site 443149001232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001234 Predicted membrane protein [Function unknown]; Region: COG2733 443149001235 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149001236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149001237 non-specific DNA binding site [nucleotide binding]; other site 443149001238 salt bridge; other site 443149001239 sequence-specific DNA binding site [nucleotide binding]; other site 443149001240 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443149001241 intersubunit interface [polypeptide binding]; other site 443149001242 active site 443149001243 catalytic residue [active] 443149001244 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149001245 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443149001246 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 443149001247 active site 443149001248 catalytic triad [active] 443149001249 dimer interface [polypeptide binding]; other site 443149001250 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443149001251 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443149001252 FAD binding domain; Region: FAD_binding_4; pfam01565 443149001253 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443149001254 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149001256 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443149001257 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149001258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149001259 NAD(P) binding site [chemical binding]; other site 443149001260 active site 443149001261 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149001262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001263 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 443149001264 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443149001265 putative ADP-binding pocket [chemical binding]; other site 443149001266 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 443149001267 L-lysine exporter; Region: 2a75; TIGR00948 443149001268 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443149001269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149001270 dimer interface [polypeptide binding]; other site 443149001271 phosphorylation site [posttranslational modification] 443149001272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149001273 ATP binding site [chemical binding]; other site 443149001274 Mg2+ binding site [ion binding]; other site 443149001275 G-X-G motif; other site 443149001276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149001277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149001278 active site 443149001279 phosphorylation site [posttranslational modification] 443149001280 intermolecular recognition site; other site 443149001281 dimerization interface [polypeptide binding]; other site 443149001282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149001283 DNA binding site [nucleotide binding] 443149001284 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 443149001285 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149001286 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149001287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149001288 DNA-binding site [nucleotide binding]; DNA binding site 443149001289 FCD domain; Region: FCD; pfam07729 443149001290 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443149001291 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443149001292 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443149001293 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443149001294 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443149001295 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 443149001296 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443149001297 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443149001298 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443149001299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149001300 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 443149001301 putative NAD(P) binding site [chemical binding]; other site 443149001302 active site 443149001303 putative substrate binding site [chemical binding]; other site 443149001304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149001305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149001306 putative acyl-acceptor binding pocket; other site 443149001307 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001310 S-adenosylmethionine binding site [chemical binding]; other site 443149001311 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001312 active site 443149001313 catalytic site [active] 443149001314 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149001315 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443149001316 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001317 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149001318 glutamyl-tRNA reductase; Region: hemA; TIGR01035 443149001319 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443149001320 tRNA; other site 443149001321 putative tRNA binding site [nucleotide binding]; other site 443149001322 putative NADP binding site [chemical binding]; other site 443149001323 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443149001324 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443149001325 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 443149001326 domain interfaces; other site 443149001327 active site 443149001328 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 443149001329 active site 443149001330 homodimer interface [polypeptide binding]; other site 443149001331 SAM binding site [chemical binding]; other site 443149001332 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443149001333 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443149001334 active site 443149001335 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443149001336 dimer interface [polypeptide binding]; other site 443149001337 active site 443149001338 Schiff base residues; other site 443149001339 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149001340 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149001341 active site 443149001342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149001343 anti sigma factor interaction site; other site 443149001344 regulatory phosphorylation site [posttranslational modification]; other site 443149001345 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149001346 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443149001347 active site 443149001348 catalytic triad [active] 443149001349 oxyanion hole [active] 443149001350 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 443149001351 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149001352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001353 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149001354 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149001355 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443149001356 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149001357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149001358 catalytic residue [active] 443149001359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149001360 catalytic core [active] 443149001361 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443149001362 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149001363 catalytic residues [active] 443149001364 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149001365 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443149001366 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443149001367 ResB-like family; Region: ResB; pfam05140 443149001368 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443149001369 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149001370 AAA domain; Region: AAA_31; pfam13614 443149001371 P-loop; other site 443149001372 Magnesium ion binding site [ion binding]; other site 443149001373 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443149001374 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443149001375 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 443149001376 UbiA prenyltransferase family; Region: UbiA; pfam01040 443149001377 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 443149001378 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149001379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149001380 NAD(P) binding site [chemical binding]; other site 443149001381 active site 443149001382 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149001383 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443149001384 Ligand binding site; other site 443149001385 Putative Catalytic site; other site 443149001386 DXD motif; other site 443149001387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 443149001388 potential frameshift: common BLAST hit: gi|383306455|ref|YP_005359266.1| O-succinylbenzoic acid--CoA ligase 443149001389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149001390 CoA binding site [chemical binding]; other site 443149001391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149001392 active site 443149001393 CoA binding site [chemical binding]; other site 443149001394 AMP binding site [chemical binding]; other site 443149001395 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443149001396 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149001397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149001398 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443149001399 active site 443149001400 short chain dehydrogenase; Provisional; Region: PRK05866 443149001401 classical (c) SDRs; Region: SDR_c; cd05233 443149001402 NAD(P) binding site [chemical binding]; other site 443149001403 active site 443149001404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001405 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443149001406 substrate binding site [chemical binding]; other site 443149001407 oxyanion hole (OAH) forming residues; other site 443149001408 trimer interface [polypeptide binding]; other site 443149001409 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149001410 putative active site [active] 443149001411 homotetrameric interface [polypeptide binding]; other site 443149001412 metal binding site [ion binding]; metal-binding site 443149001413 acyl-CoA synthetase; Validated; Region: PRK06188 443149001414 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149001415 putative active site [active] 443149001416 putative CoA binding site [chemical binding]; other site 443149001417 putative AMP binding site [chemical binding]; other site 443149001418 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443149001419 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 443149001420 active site 443149001421 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443149001422 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443149001423 active site 443149001424 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149001425 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443149001426 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149001427 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443149001428 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443149001429 dimer interface [polypeptide binding]; other site 443149001430 tetramer interface [polypeptide binding]; other site 443149001431 PYR/PP interface [polypeptide binding]; other site 443149001432 TPP binding site [chemical binding]; other site 443149001433 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443149001434 TPP-binding site; other site 443149001435 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 443149001436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149001437 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443149001438 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443149001439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001440 S-adenosylmethionine binding site [chemical binding]; other site 443149001441 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149001442 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149001443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001444 S-adenosylmethionine binding site [chemical binding]; other site 443149001445 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 443149001446 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149001447 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149001448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149001449 substrate binding pocket [chemical binding]; other site 443149001450 chain length determination region; other site 443149001451 substrate-Mg2+ binding site; other site 443149001452 catalytic residues [active] 443149001453 aspartate-rich region 1; other site 443149001454 active site lid residues [active] 443149001455 aspartate-rich region 2; other site 443149001456 heat shock protein HtpX; Provisional; Region: PRK03072 443149001457 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 443149001458 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443149001459 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443149001460 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149001461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149001462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443149001463 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443149001464 O-methyltransferase; Region: Methyltransf_2; pfam00891 443149001465 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149001466 Cytochrome P450; Region: p450; cl12078 443149001467 ATP cone domain; Region: ATP-cone; pfam03477 443149001468 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 443149001469 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 443149001470 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 443149001471 active site 443149001472 dimer interface [polypeptide binding]; other site 443149001473 effector binding site; other site 443149001474 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443149001475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149001476 active site 443149001477 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149001478 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149001479 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 443149001480 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443149001481 active site 443149001482 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 443149001483 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443149001484 putative active site [active] 443149001485 putative metal binding site [ion binding]; other site 443149001486 hypothetical protein; Provisional; Region: PRK07588 443149001487 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149001488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149001489 dimerization interface [polypeptide binding]; other site 443149001490 putative DNA binding site [nucleotide binding]; other site 443149001491 putative Zn2+ binding site [ion binding]; other site 443149001492 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443149001493 putative hydrophobic ligand binding site [chemical binding]; other site 443149001494 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149001495 TIGR03086 family protein; Region: TIGR03086 443149001496 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149001497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149001498 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149001499 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 443149001500 Uncharacterized conserved protein [Function unknown]; Region: COG1656 443149001501 Protein of unknown function DUF82; Region: DUF82; pfam01927 443149001502 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149001503 putative active site [active] 443149001504 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149001505 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 443149001506 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 443149001507 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 443149001508 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149001509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149001510 DNA-binding site [nucleotide binding]; DNA binding site 443149001511 FCD domain; Region: FCD; pfam07729 443149001512 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149001513 Permease; Region: Permease; pfam02405 443149001514 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149001515 Permease; Region: Permease; pfam02405 443149001516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001517 mce related protein; Region: MCE; pfam02470 443149001518 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001519 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443149001520 mce related protein; Region: MCE; pfam02470 443149001521 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001522 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001523 mce related protein; Region: MCE; pfam02470 443149001524 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001525 mce related protein; Region: MCE; pfam02470 443149001526 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149001527 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001528 mce related protein; Region: MCE; pfam02470 443149001529 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149001530 mce related protein; Region: MCE; pfam02470 443149001531 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149001532 oligomeric interface; other site 443149001533 putative active site [active] 443149001534 homodimer interface [polypeptide binding]; other site 443149001535 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149001536 AAA domain; Region: AAA_14; pfam13173 443149001537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149001538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149001539 ATP binding site [chemical binding]; other site 443149001540 Mg2+ binding site [ion binding]; other site 443149001541 G-X-G motif; other site 443149001542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149001543 dimerization interface [polypeptide binding]; other site 443149001544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149001545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149001546 active site 443149001547 phosphorylation site [posttranslational modification] 443149001548 intermolecular recognition site; other site 443149001549 dimerization interface [polypeptide binding]; other site 443149001550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149001551 DNA binding site [nucleotide binding] 443149001552 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149001553 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149001554 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149001555 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149001556 catalytic residues [active] 443149001557 catalytic nucleophile [active] 443149001558 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149001559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149001560 Probable transposase; Region: OrfB_IS605; pfam01385 443149001561 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149001562 putative active site [active] 443149001563 SEC-C motif; Region: SEC-C; pfam02810 443149001564 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 443149001565 putative active site [active] 443149001566 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 443149001567 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443149001568 nucleotide binding site/active site [active] 443149001569 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443149001570 galactokinase; Provisional; Region: PRK00555 443149001571 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 443149001572 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149001573 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149001574 putative active site [active] 443149001575 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443149001576 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443149001577 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149001578 oligomeric interface; other site 443149001579 putative active site [active] 443149001580 homodimer interface [polypeptide binding]; other site 443149001581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443149001582 FIST N domain; Region: FIST; pfam08495 443149001583 FIST C domain; Region: FIST_C; pfam10442 443149001584 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 443149001585 AAA domain; Region: AAA_30; pfam13604 443149001586 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443149001587 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443149001588 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 443149001589 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443149001590 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149001591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001592 substrate binding site [chemical binding]; other site 443149001593 oxyanion hole (OAH) forming residues; other site 443149001594 trimer interface [polypeptide binding]; other site 443149001595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149001596 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001597 active site 443149001598 catalytic site [active] 443149001599 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 443149001600 active site 443149001601 catalytic site [active] 443149001602 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149001603 active site 443149001604 catalytic site [active] 443149001605 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443149001606 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443149001607 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443149001608 putative homodimer interface [polypeptide binding]; other site 443149001609 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443149001610 heterodimer interface [polypeptide binding]; other site 443149001611 homodimer interface [polypeptide binding]; other site 443149001612 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443149001613 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443149001614 23S rRNA interface [nucleotide binding]; other site 443149001615 L7/L12 interface [polypeptide binding]; other site 443149001616 putative thiostrepton binding site; other site 443149001617 L25 interface [polypeptide binding]; other site 443149001618 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443149001619 mRNA/rRNA interface [nucleotide binding]; other site 443149001620 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001622 S-adenosylmethionine binding site [chemical binding]; other site 443149001623 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001626 S-adenosylmethionine binding site [chemical binding]; other site 443149001627 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001630 S-adenosylmethionine binding site [chemical binding]; other site 443149001631 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149001632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149001634 S-adenosylmethionine binding site [chemical binding]; other site 443149001635 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149001636 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 443149001637 ABC1 family; Region: ABC1; cl17513 443149001638 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 443149001639 active site 443149001640 catalytic site [active] 443149001641 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 443149001642 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 443149001643 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 443149001644 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149001645 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001646 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443149001647 23S rRNA interface [nucleotide binding]; other site 443149001648 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443149001649 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443149001650 core dimer interface [polypeptide binding]; other site 443149001651 peripheral dimer interface [polypeptide binding]; other site 443149001652 L10 interface [polypeptide binding]; other site 443149001653 L11 interface [polypeptide binding]; other site 443149001654 putative EF-Tu interaction site [polypeptide binding]; other site 443149001655 putative EF-G interaction site [polypeptide binding]; other site 443149001656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001658 WHG domain; Region: WHG; pfam13305 443149001659 potential frameshift: common BLAST hit: gi|378770409|ref|YP_005170142.1| putative dioxygenase 443149001660 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 443149001661 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 443149001662 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443149001663 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 443149001664 Walker A/P-loop; other site 443149001665 ATP binding site [chemical binding]; other site 443149001666 Q-loop/lid; other site 443149001667 ABC transporter signature motif; other site 443149001668 Walker B; other site 443149001669 D-loop; other site 443149001670 H-loop/switch region; other site 443149001671 CAAX protease self-immunity; Region: Abi; cl00558 443149001672 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 443149001673 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149001674 Sulfatase; Region: Sulfatase; pfam00884 443149001675 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443149001676 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149001677 putative active site [active] 443149001678 potential frameshift: common BLAST hit: gi|375294884|ref|YP_005099151.1| DNA-directed RNA polymerase subunit beta rpoB 443149001679 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 443149001680 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443149001681 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 443149001682 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443149001683 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443149001684 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 443149001685 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443149001686 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443149001687 RPB10 interaction site [polypeptide binding]; other site 443149001688 RPB1 interaction site [polypeptide binding]; other site 443149001689 RPB11 interaction site [polypeptide binding]; other site 443149001690 RPB3 interaction site [polypeptide binding]; other site 443149001691 RPB12 interaction site [polypeptide binding]; other site 443149001692 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443149001693 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443149001694 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443149001695 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443149001696 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443149001697 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443149001698 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443149001699 G-loop; other site 443149001700 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443149001701 DNA binding site [nucleotide binding] 443149001702 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443149001703 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 443149001704 endonuclease IV; Provisional; Region: PRK01060 443149001705 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443149001706 AP (apurinic/apyrimidinic) site pocket; other site 443149001707 DNA interaction; other site 443149001708 Metal-binding active site; metal-binding site 443149001709 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443149001710 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 443149001711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149001712 active site 443149001713 enoyl-CoA hydratase; Provisional; Region: PRK12478 443149001714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001715 substrate binding site [chemical binding]; other site 443149001716 oxyanion hole (OAH) forming residues; other site 443149001717 trimer interface [polypeptide binding]; other site 443149001718 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 443149001719 PaaX-like protein; Region: PaaX; pfam07848 443149001720 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 443149001721 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149001722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149001723 substrate binding site [chemical binding]; other site 443149001724 oxyanion hole (OAH) forming residues; other site 443149001725 trimer interface [polypeptide binding]; other site 443149001726 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149001727 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149001728 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149001729 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 443149001730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001732 WHG domain; Region: WHG; pfam13305 443149001733 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443149001734 S17 interaction site [polypeptide binding]; other site 443149001735 S8 interaction site; other site 443149001736 16S rRNA interaction site [nucleotide binding]; other site 443149001737 streptomycin interaction site [chemical binding]; other site 443149001738 23S rRNA interaction site [nucleotide binding]; other site 443149001739 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443149001740 30S ribosomal protein S7; Validated; Region: PRK05302 443149001741 elongation factor G; Reviewed; Region: PRK00007 443149001742 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443149001743 G1 box; other site 443149001744 putative GEF interaction site [polypeptide binding]; other site 443149001745 GTP/Mg2+ binding site [chemical binding]; other site 443149001746 Switch I region; other site 443149001747 G2 box; other site 443149001748 G3 box; other site 443149001749 Switch II region; other site 443149001750 G4 box; other site 443149001751 G5 box; other site 443149001752 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443149001753 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443149001754 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443149001755 elongation factor Tu; Reviewed; Region: PRK00049 443149001756 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443149001757 G1 box; other site 443149001758 GEF interaction site [polypeptide binding]; other site 443149001759 GTP/Mg2+ binding site [chemical binding]; other site 443149001760 Switch I region; other site 443149001761 G2 box; other site 443149001762 G3 box; other site 443149001763 Switch II region; other site 443149001764 G4 box; other site 443149001765 G5 box; other site 443149001766 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443149001767 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443149001768 Antibiotic Binding Site [chemical binding]; other site 443149001769 Short C-terminal domain; Region: SHOCT; pfam09851 443149001770 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 443149001771 classical (c) SDRs; Region: SDR_c; cd05233 443149001772 NAD(P) binding site [chemical binding]; other site 443149001773 active site 443149001774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443149001775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149001776 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 443149001777 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443149001778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149001779 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 443149001780 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 443149001781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149001782 FeS/SAM binding site; other site 443149001783 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 443149001784 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443149001785 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149001786 phosphate binding site [ion binding]; other site 443149001787 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 443149001788 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 443149001789 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149001790 Probable Catalytic site; other site 443149001791 metal-binding site 443149001792 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 443149001793 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149001794 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443149001795 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443149001796 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443149001797 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443149001798 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443149001799 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443149001800 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443149001801 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443149001802 putative translocon binding site; other site 443149001803 protein-rRNA interface [nucleotide binding]; other site 443149001804 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443149001805 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443149001806 G-X-X-G motif; other site 443149001807 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443149001808 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443149001809 23S rRNA interface [nucleotide binding]; other site 443149001810 5S rRNA interface [nucleotide binding]; other site 443149001811 putative antibiotic binding site [chemical binding]; other site 443149001812 L25 interface [polypeptide binding]; other site 443149001813 L27 interface [polypeptide binding]; other site 443149001814 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443149001815 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149001816 Sulfatase; Region: Sulfatase; pfam00884 443149001817 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 443149001818 Uncharacterized conserved protein [Function unknown]; Region: COG1262 443149001819 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443149001820 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443149001821 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443149001822 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443149001823 RNA binding site [nucleotide binding]; other site 443149001824 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443149001825 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443149001826 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443149001827 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443149001828 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443149001829 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443149001830 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443149001831 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443149001832 5S rRNA interface [nucleotide binding]; other site 443149001833 23S rRNA interface [nucleotide binding]; other site 443149001834 L5 interface [polypeptide binding]; other site 443149001835 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443149001836 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443149001837 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443149001838 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443149001839 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 443149001840 tandem repeat interface [polypeptide binding]; other site 443149001841 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443149001842 oligomer interface [polypeptide binding]; other site 443149001843 active site residues [active] 443149001844 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 443149001845 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443149001846 tandem repeat interface [polypeptide binding]; other site 443149001847 oligomer interface [polypeptide binding]; other site 443149001848 active site residues [active] 443149001849 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001850 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001851 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001852 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001853 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 443149001854 intersubunit interface [polypeptide binding]; other site 443149001855 active site 443149001856 Zn2+ binding site [ion binding]; other site 443149001857 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443149001858 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443149001859 NAD binding site [chemical binding]; other site 443149001860 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443149001861 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149001862 nucleotide binding site [chemical binding]; other site 443149001863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149001864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149001865 Coenzyme A binding pocket [chemical binding]; other site 443149001866 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149001867 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149001868 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443149001869 SecY translocase; Region: SecY; pfam00344 443149001870 adenylate kinase; Reviewed; Region: adk; PRK00279 443149001871 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443149001872 AMP-binding site [chemical binding]; other site 443149001873 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443149001874 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443149001875 active site 443149001876 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443149001877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149001878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149001879 DNA binding residues [nucleotide binding] 443149001880 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 443149001881 Putative zinc-finger; Region: zf-HC2; pfam13490 443149001882 MarR family; Region: MarR; pfam01047 443149001883 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149001884 TIGR03086 family protein; Region: TIGR03086 443149001885 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 443149001886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149001887 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149001888 Helix-turn-helix domain; Region: HTH_17; pfam12728 443149001889 PE family; Region: PE; pfam00934 443149001890 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149001891 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149001892 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 443149001893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149001894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149001895 active site 443149001896 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443149001897 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443149001898 tetrameric interface [polypeptide binding]; other site 443149001899 NAD binding site [chemical binding]; other site 443149001900 catalytic residues [active] 443149001901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149001902 catalytic core [active] 443149001903 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149001904 PPE family; Region: PPE; pfam00823 443149001905 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149001906 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149001907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149001908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149001909 active site 443149001910 phosphorylation site [posttranslational modification] 443149001911 intermolecular recognition site; other site 443149001912 dimerization interface [polypeptide binding]; other site 443149001913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149001914 DNA binding site [nucleotide binding] 443149001915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149001916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149001917 dimerization interface [polypeptide binding]; other site 443149001918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149001919 dimer interface [polypeptide binding]; other site 443149001920 phosphorylation site [posttranslational modification] 443149001921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149001922 ATP binding site [chemical binding]; other site 443149001923 Mg2+ binding site [ion binding]; other site 443149001924 G-X-G motif; other site 443149001925 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 443149001926 nucleotide binding site/active site [active] 443149001927 HIT family signature motif; other site 443149001928 catalytic residue [active] 443149001929 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443149001930 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443149001931 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149001932 NAD binding site [chemical binding]; other site 443149001933 catalytic Zn binding site [ion binding]; other site 443149001934 substrate binding site [chemical binding]; other site 443149001935 structural Zn binding site [ion binding]; other site 443149001936 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443149001937 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149001938 Cytochrome P450; Region: p450; cl12078 443149001939 short chain dehydrogenase; Provisional; Region: PRK07775 443149001940 classical (c) SDRs; Region: SDR_c; cd05233 443149001941 NAD(P) binding site [chemical binding]; other site 443149001942 active site 443149001943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149001944 Cytochrome P450; Region: p450; cl12078 443149001945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149001946 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 443149001947 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 443149001948 NAD binding site [chemical binding]; other site 443149001949 catalytic residues [active] 443149001950 short chain dehydrogenase; Provisional; Region: PRK07774 443149001951 classical (c) SDRs; Region: SDR_c; cd05233 443149001952 NAD(P) binding site [chemical binding]; other site 443149001953 active site 443149001954 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149001955 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 443149001956 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443149001957 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443149001958 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443149001959 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443149001960 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443149001961 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443149001962 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443149001963 Predicted esterase [General function prediction only]; Region: COG0627 443149001964 S-formylglutathione hydrolase; Region: PLN02442 443149001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443149001966 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 443149001967 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 443149001968 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 443149001969 tetramer interface [polypeptide binding]; other site 443149001970 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149001971 Cytochrome P450; Region: p450; cl12078 443149001972 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443149001973 ATP binding site [chemical binding]; other site 443149001974 active site 443149001975 substrate binding site [chemical binding]; other site 443149001976 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443149001977 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149001978 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149001979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149001980 putative substrate translocation pore; other site 443149001981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149001982 Predicted deacetylase [General function prediction only]; Region: COG3233 443149001983 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 443149001984 putative active site [active] 443149001985 putative Zn binding site [ion binding]; other site 443149001986 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443149001987 FAD binding domain; Region: FAD_binding_2; pfam00890 443149001988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149001989 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 443149001990 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443149001991 putative active site [active] 443149001992 catalytic triad [active] 443149001993 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149001994 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443149001995 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149001996 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443149001997 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149001998 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443149001999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149002000 DNA-binding site [nucleotide binding]; DNA binding site 443149002001 UTRA domain; Region: UTRA; pfam07702 443149002002 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149002003 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443149002004 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 443149002005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149002006 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149002007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149002008 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149002009 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149002010 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 443149002011 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 443149002012 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 443149002013 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 443149002014 active site 443149002015 metal binding site [ion binding]; metal-binding site 443149002016 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443149002017 active site 443149002018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002019 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443149002020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149002021 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443149002022 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443149002023 dimerization interface [polypeptide binding]; other site 443149002024 ATP binding site [chemical binding]; other site 443149002025 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443149002026 dimerization interface [polypeptide binding]; other site 443149002027 ATP binding site [chemical binding]; other site 443149002028 CAAX protease self-immunity; Region: Abi; pfam02517 443149002029 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 443149002030 amidophosphoribosyltransferase; Provisional; Region: PRK07847 443149002031 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443149002032 active site 443149002033 tetramer interface [polypeptide binding]; other site 443149002034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149002035 active site 443149002036 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 443149002037 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443149002038 dimerization interface [polypeptide binding]; other site 443149002039 putative ATP binding site [chemical binding]; other site 443149002040 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443149002041 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443149002042 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 443149002043 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 443149002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002045 catalytic residue [active] 443149002046 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443149002047 heme-binding site [chemical binding]; other site 443149002048 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443149002049 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149002050 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149002051 active site residue [active] 443149002052 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149002053 active site residue [active] 443149002054 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149002055 catalytic residues [active] 443149002056 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149002057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002059 DNA binding site [nucleotide binding] 443149002060 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443149002061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002062 Coenzyme A binding pocket [chemical binding]; other site 443149002063 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443149002064 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443149002065 Walker A/P-loop; other site 443149002066 ATP binding site [chemical binding]; other site 443149002067 Q-loop/lid; other site 443149002068 ABC transporter signature motif; other site 443149002069 Walker B; other site 443149002070 D-loop; other site 443149002071 H-loop/switch region; other site 443149002072 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443149002073 PhoU domain; Region: PhoU; pfam01895 443149002074 PhoU domain; Region: PhoU; pfam01895 443149002075 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 443149002076 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149002077 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443149002078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443149002079 FMN binding site [chemical binding]; other site 443149002080 active site 443149002081 catalytic residues [active] 443149002082 substrate binding site [chemical binding]; other site 443149002083 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 443149002084 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 443149002085 homodimer interface [polypeptide binding]; other site 443149002086 putative substrate binding pocket [chemical binding]; other site 443149002087 diiron center [ion binding]; other site 443149002088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149002089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149002090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149002091 dimerization interface [polypeptide binding]; other site 443149002092 putative DNA binding site [nucleotide binding]; other site 443149002093 putative Zn2+ binding site [ion binding]; other site 443149002094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443149002095 dimer interface [polypeptide binding]; other site 443149002096 catalytic motif [active] 443149002097 nucleoside/Zn binding site; other site 443149002098 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149002099 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149002100 TIGR04255 family protein; Region: sporadTIGR04255 443149002101 PE family; Region: PE; pfam00934 443149002102 PE family; Region: PE; pfam00934 443149002103 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149002104 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 443149002105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 443149002106 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 443149002107 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 443149002108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002109 S-adenosylmethionine binding site [chemical binding]; other site 443149002110 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 443149002111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002112 putative substrate translocation pore; other site 443149002113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149002114 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443149002115 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443149002116 tetramer interface [polypeptide binding]; other site 443149002117 TPP-binding site [chemical binding]; other site 443149002118 heterodimer interface [polypeptide binding]; other site 443149002119 phosphorylation loop region [posttranslational modification] 443149002120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002122 active site 443149002123 phosphorylation site [posttranslational modification] 443149002124 intermolecular recognition site; other site 443149002125 dimerization interface [polypeptide binding]; other site 443149002126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149002127 DNA binding residues [nucleotide binding] 443149002128 dimerization interface [polypeptide binding]; other site 443149002129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149002130 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443149002131 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443149002132 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 443149002133 Multicopper oxidase; Region: Cu-oxidase; pfam00394 443149002134 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 443149002135 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149002136 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149002137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002138 catalytic residue [active] 443149002139 dimer interface [polypeptide binding]; other site 443149002140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149002141 multidrug resistance protein MdtH; Provisional; Region: PRK11646 443149002142 putative substrate translocation pore; other site 443149002143 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 443149002144 short chain dehydrogenase; Provisional; Region: PRK05876 443149002145 classical (c) SDRs; Region: SDR_c; cd05233 443149002146 NAD(P) binding site [chemical binding]; other site 443149002147 active site 443149002148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149002149 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 443149002150 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 443149002151 dimer interface [polypeptide binding]; other site 443149002152 PYR/PP interface [polypeptide binding]; other site 443149002153 TPP binding site [chemical binding]; other site 443149002154 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149002155 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 443149002156 TPP-binding site [chemical binding]; other site 443149002157 dimer interface [polypeptide binding]; other site 443149002158 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002159 putative hydrophobic ligand binding site [chemical binding]; other site 443149002160 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149002161 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149002162 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002163 putative hydrophobic ligand binding site [chemical binding]; other site 443149002164 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149002165 putative hydrophobic ligand binding site [chemical binding]; other site 443149002166 aminotransferase; Validated; Region: PRK07777 443149002167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002169 homodimer interface [polypeptide binding]; other site 443149002170 catalytic residue [active] 443149002171 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443149002172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149002173 dimer interface [polypeptide binding]; other site 443149002174 active site 443149002175 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443149002176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002177 substrate binding site [chemical binding]; other site 443149002178 oxyanion hole (OAH) forming residues; other site 443149002179 trimer interface [polypeptide binding]; other site 443149002180 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149002181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149002182 potential frameshift: common BLAST hit: gi|375297350|ref|YP_005101617.1| DNA helicase ercc3 443149002183 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149002184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149002185 nucleotide binding region [chemical binding]; other site 443149002186 ATP-binding site [chemical binding]; other site 443149002187 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443149002188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149002189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149002190 ATP binding site [chemical binding]; other site 443149002191 putative Mg++ binding site [ion binding]; other site 443149002192 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443149002193 WYL domain; Region: WYL; pfam13280 443149002194 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149002195 trimer interface [polypeptide binding]; other site 443149002196 dimer interface [polypeptide binding]; other site 443149002197 putative active site [active] 443149002198 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443149002199 MPT binding site; other site 443149002200 trimer interface [polypeptide binding]; other site 443149002201 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149002202 MoaE homodimer interface [polypeptide binding]; other site 443149002203 MoaD interaction [polypeptide binding]; other site 443149002204 active site residues [active] 443149002205 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149002206 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443149002207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149002208 FeS/SAM binding site; other site 443149002209 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149002210 hypothetical protein; Provisional; Region: PRK11770 443149002211 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443149002212 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443149002213 PE family; Region: PE; pfam00934 443149002214 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149002215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002216 active site 443149002217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 443149002218 FIST N domain; Region: FIST; pfam08495 443149002219 FIST C domain; Region: FIST_C; pfam10442 443149002220 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 443149002221 H+ Antiporter protein; Region: 2A0121; TIGR00900 443149002222 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443149002223 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002224 PPE family; Region: PPE; pfam00823 443149002225 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002226 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002227 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149002228 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149002229 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443149002230 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 443149002231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149002232 catalytic residue [active] 443149002233 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 443149002234 Ferredoxin [Energy production and conversion]; Region: COG1146 443149002235 4Fe-4S binding domain; Region: Fer4; pfam00037 443149002236 ferredoxin-NADP+ reductase; Region: PLN02852 443149002237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149002238 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443149002239 putative dimer interface [polypeptide binding]; other site 443149002240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002241 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443149002242 putative catalytic site [active] 443149002243 putative phosphate binding site [ion binding]; other site 443149002244 putative metal binding site [ion binding]; other site 443149002245 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 443149002246 dimer interface [polypeptide binding]; other site 443149002247 Citrate synthase; Region: Citrate_synt; pfam00285 443149002248 active site 443149002249 citrylCoA binding site [chemical binding]; other site 443149002250 oxalacetate/citrate binding site [chemical binding]; other site 443149002251 coenzyme A binding site [chemical binding]; other site 443149002252 catalytic triad [active] 443149002253 Predicted ATPase [General function prediction only]; Region: COG3903 443149002254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149002255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149002256 DNA binding residues [nucleotide binding] 443149002257 dimerization interface [polypeptide binding]; other site 443149002258 cyclase homology domain; Region: CHD; cd07302 443149002259 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149002260 nucleotidyl binding site; other site 443149002261 metal binding site [ion binding]; metal-binding site 443149002262 dimer interface [polypeptide binding]; other site 443149002263 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149002264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149002265 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149002266 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149002267 AAA ATPase domain; Region: AAA_16; pfam13191 443149002268 Predicted ATPase [General function prediction only]; Region: COG3903 443149002269 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149002270 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149002271 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443149002272 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 443149002273 dimer interface [polypeptide binding]; other site 443149002274 active site 443149002275 citrylCoA binding site [chemical binding]; other site 443149002276 NADH binding [chemical binding]; other site 443149002277 cationic pore residues; other site 443149002278 oxalacetate/citrate binding site [chemical binding]; other site 443149002279 coenzyme A binding site [chemical binding]; other site 443149002280 catalytic triad [active] 443149002281 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149002282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149002283 BON domain; Region: BON; pfam04972 443149002284 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 443149002285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 443149002286 ligand binding site [chemical binding]; other site 443149002287 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 443149002288 potential frameshift: common BLAST hit: gi|383306793|ref|YP_005359604.1| sensor histidine kinase 443149002289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149002290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149002291 dimerization interface [polypeptide binding]; other site 443149002292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002293 dimer interface [polypeptide binding]; other site 443149002294 phosphorylation site [posttranslational modification] 443149002295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002296 Mg2+ binding site [ion binding]; other site 443149002297 G-X-G motif; other site 443149002298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002300 active site 443149002301 phosphorylation site [posttranslational modification] 443149002302 intermolecular recognition site; other site 443149002303 dimerization interface [polypeptide binding]; other site 443149002304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002305 DNA binding site [nucleotide binding] 443149002306 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 443149002307 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 443149002308 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149002309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002310 substrate binding site [chemical binding]; other site 443149002311 oxyanion hole (OAH) forming residues; other site 443149002312 trimer interface [polypeptide binding]; other site 443149002313 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149002314 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 443149002315 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149002316 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149002317 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 443149002318 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149002319 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002320 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002321 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149002322 hydrophobic ligand binding site; other site 443149002323 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149002324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002325 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443149002326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149002327 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443149002328 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 443149002329 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 443149002330 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149002331 active site 443149002332 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002333 PPE family; Region: PPE; pfam00823 443149002334 BCCT family transporter; Region: BCCT; pfam02028 443149002335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002336 Coenzyme A binding pocket [chemical binding]; other site 443149002337 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149002338 MULE transposase domain; Region: MULE; pfam10551 443149002339 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149002340 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149002341 catalytic residues [active] 443149002342 catalytic nucleophile [active] 443149002343 potential frameshift: common BLAST hit: gi|383306812|ref|YP_005359623.1| putative transposase 443149002344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149002345 Probable transposase; Region: OrfB_IS605; pfam01385 443149002346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149002347 Probable transposase; Region: OrfB_IS605; pfam01385 443149002348 Protein of unknown function (DUF867); Region: DUF867; cl01713 443149002349 manganese transport protein MntH; Reviewed; Region: PRK00701 443149002350 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 443149002351 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443149002352 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443149002353 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443149002354 short chain dehydrogenase; Provisional; Region: PRK07814 443149002355 classical (c) SDRs; Region: SDR_c; cd05233 443149002356 NAD(P) binding site [chemical binding]; other site 443149002357 active site 443149002358 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443149002359 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443149002360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002361 dimer interface [polypeptide binding]; other site 443149002362 conserved gate region; other site 443149002363 putative PBP binding loops; other site 443149002364 ABC-ATPase subunit interface; other site 443149002365 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443149002366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002367 dimer interface [polypeptide binding]; other site 443149002368 conserved gate region; other site 443149002369 putative PBP binding loops; other site 443149002370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443149002371 ABC-ATPase subunit interface; other site 443149002372 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149002373 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149002374 active site 443149002375 ATP binding site [chemical binding]; other site 443149002376 substrate binding site [chemical binding]; other site 443149002377 activation loop (A-loop); other site 443149002378 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002379 NHL repeat; Region: NHL; pfam01436 443149002380 NHL repeat; Region: NHL; pfam01436 443149002381 NHL repeat; Region: NHL; pfam01436 443149002382 NHL repeat; Region: NHL; pfam01436 443149002383 NHL repeat; Region: NHL; pfam01436 443149002384 PBP superfamily domain; Region: PBP_like_2; cl17296 443149002385 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 443149002386 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443149002387 Walker A/P-loop; other site 443149002388 ATP binding site [chemical binding]; other site 443149002389 Q-loop/lid; other site 443149002390 ABC transporter signature motif; other site 443149002391 Walker B; other site 443149002392 D-loop; other site 443149002393 H-loop/switch region; other site 443149002394 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 443149002395 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443149002396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002397 dimer interface [polypeptide binding]; other site 443149002398 conserved gate region; other site 443149002399 putative PBP binding loops; other site 443149002400 ABC-ATPase subunit interface; other site 443149002401 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443149002402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149002403 dimer interface [polypeptide binding]; other site 443149002404 conserved gate region; other site 443149002405 putative PBP binding loops; other site 443149002406 ABC-ATPase subunit interface; other site 443149002407 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443149002408 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443149002409 putative DNA binding site [nucleotide binding]; other site 443149002410 putative homodimer interface [polypeptide binding]; other site 443149002411 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443149002412 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443149002413 nucleotide binding site [chemical binding]; other site 443149002414 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 443149002415 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443149002416 active site 443149002417 DNA binding site [nucleotide binding] 443149002418 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443149002419 DNA binding site [nucleotide binding] 443149002420 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443149002421 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443149002422 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149002423 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149002424 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149002425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149002426 anti sigma factor interaction site; other site 443149002427 regulatory phosphorylation site [posttranslational modification]; other site 443149002428 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149002429 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149002430 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149002431 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149002432 short chain dehydrogenase; Provisional; Region: PRK08251 443149002433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149002434 NAD(P) binding site [chemical binding]; other site 443149002435 active site 443149002436 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 443149002437 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443149002438 active site 443149002439 dimer interface [polypeptide binding]; other site 443149002440 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443149002441 dimer interface [polypeptide binding]; other site 443149002442 active site 443149002443 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443149002444 Part of AAA domain; Region: AAA_19; pfam13245 443149002445 Family description; Region: UvrD_C_2; pfam13538 443149002446 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443149002447 Peptidase family M23; Region: Peptidase_M23; pfam01551 443149002448 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443149002449 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443149002450 CoA-ligase; Region: Ligase_CoA; pfam00549 443149002451 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443149002452 CoA binding domain; Region: CoA_binding; smart00881 443149002453 CoA-ligase; Region: Ligase_CoA; pfam00549 443149002454 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149002455 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149002456 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443149002457 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443149002458 active site 443149002459 cosubstrate binding site; other site 443149002460 substrate binding site [chemical binding]; other site 443149002461 catalytic site [active] 443149002462 potential frameshift: common BLAST hit: gi|383306843|ref|YP_005359654.1| bifunctional phosphoribosylaminoimidazolecarboxamide 443149002463 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443149002464 purine monophosphate binding site [chemical binding]; other site 443149002465 dimer interface [polypeptide binding]; other site 443149002466 putative catalytic residues [active] 443149002467 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443149002468 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443149002469 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 443149002470 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443149002471 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 443149002472 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149002473 metal ion-dependent adhesion site (MIDAS); other site 443149002474 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149002475 homotetrameric interface [polypeptide binding]; other site 443149002476 putative active site [active] 443149002477 metal binding site [ion binding]; metal-binding site 443149002478 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149002479 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149002480 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 443149002481 putative homodimer interface [polypeptide binding]; other site 443149002482 putative homotetramer interface [polypeptide binding]; other site 443149002483 allosteric switch controlling residues; other site 443149002484 putative metal binding site [ion binding]; other site 443149002485 putative homodimer-homodimer interface [polypeptide binding]; other site 443149002486 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443149002487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002488 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002489 enoyl-CoA hydratase; Provisional; Region: PRK07827 443149002490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002491 substrate binding site [chemical binding]; other site 443149002492 oxyanion hole (OAH) forming residues; other site 443149002493 trimer interface [polypeptide binding]; other site 443149002494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002495 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149002496 active site 443149002497 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149002498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149002499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149002500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149002501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149002502 carboxyltransferase (CT) interaction site; other site 443149002503 biotinylation site [posttranslational modification]; other site 443149002504 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149002505 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149002506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149002507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149002508 active site 443149002509 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 443149002510 PE family; Region: PE; pfam00934 443149002511 PE family; Region: PE; pfam00934 443149002512 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002513 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002514 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002515 PE family; Region: PE; pfam00934 443149002516 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002517 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002518 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002519 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 443149002520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002522 active site 443149002523 phosphorylation site [posttranslational modification] 443149002524 intermolecular recognition site; other site 443149002525 dimerization interface [polypeptide binding]; other site 443149002526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002527 DNA binding site [nucleotide binding] 443149002528 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443149002529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149002530 dimerization interface [polypeptide binding]; other site 443149002531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002532 dimer interface [polypeptide binding]; other site 443149002533 phosphorylation site [posttranslational modification] 443149002534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002535 ATP binding site [chemical binding]; other site 443149002536 Mg2+ binding site [ion binding]; other site 443149002537 G-X-G motif; other site 443149002538 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 443149002539 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149002540 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443149002541 MPT binding site; other site 443149002542 trimer interface [polypeptide binding]; other site 443149002543 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443149002544 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 443149002545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149002546 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443149002547 Walker A/P-loop; other site 443149002548 ATP binding site [chemical binding]; other site 443149002549 Q-loop/lid; other site 443149002550 ABC transporter signature motif; other site 443149002551 Walker B; other site 443149002552 D-loop; other site 443149002553 H-loop/switch region; other site 443149002554 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443149002555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149002556 FtsX-like permease family; Region: FtsX; pfam02687 443149002557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149002558 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443149002559 FtsX-like permease family; Region: FtsX; pfam02687 443149002560 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 443149002561 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149002562 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149002563 substrate binding pocket [chemical binding]; other site 443149002564 chain length determination region; other site 443149002565 substrate-Mg2+ binding site; other site 443149002566 catalytic residues [active] 443149002567 aspartate-rich region 1; other site 443149002568 active site lid residues [active] 443149002569 aspartate-rich region 2; other site 443149002570 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 443149002571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 443149002572 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 443149002573 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443149002574 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 443149002575 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 443149002576 active site 443149002577 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443149002578 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443149002579 dimer interface [polypeptide binding]; other site 443149002580 putative functional site; other site 443149002581 putative MPT binding site; other site 443149002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149002583 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443149002584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002585 S-adenosylmethionine binding site [chemical binding]; other site 443149002586 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149002587 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149002588 ligand binding site [chemical binding]; other site 443149002589 flexible hinge region; other site 443149002590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149002591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149002592 Coenzyme A binding pocket [chemical binding]; other site 443149002593 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 443149002594 arginine deiminase; Provisional; Region: PRK01388 443149002595 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 443149002596 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443149002597 Predicted methyltransferases [General function prediction only]; Region: COG0313 443149002598 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443149002599 putative SAM binding site [chemical binding]; other site 443149002600 putative homodimer interface [polypeptide binding]; other site 443149002601 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 443149002602 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 443149002603 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443149002604 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443149002605 active site 443149002606 HIGH motif; other site 443149002607 KMSKS motif; other site 443149002608 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443149002609 tRNA binding surface [nucleotide binding]; other site 443149002610 anticodon binding site; other site 443149002611 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 443149002612 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443149002613 active site 443149002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 443149002615 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443149002616 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443149002617 G5 domain; Region: G5; pfam07501 443149002618 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149002619 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443149002620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149002621 S-adenosylmethionine binding site [chemical binding]; other site 443149002622 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443149002623 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 443149002624 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443149002625 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 443149002626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149002627 acyl-activating enzyme (AAE) consensus motif; other site 443149002628 AMP binding site [chemical binding]; other site 443149002629 active site 443149002630 CoA binding site [chemical binding]; other site 443149002631 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443149002632 putative active site [active] 443149002633 catalytic residue [active] 443149002634 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443149002635 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 443149002636 5S rRNA interface [nucleotide binding]; other site 443149002637 CTC domain interface [polypeptide binding]; other site 443149002638 L16 interface [polypeptide binding]; other site 443149002639 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443149002640 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443149002641 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443149002642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149002643 active site 443149002644 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443149002645 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443149002646 Substrate binding site; other site 443149002647 Mg++ binding site; other site 443149002648 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443149002649 active site 443149002650 substrate binding site [chemical binding]; other site 443149002651 CoA binding site [chemical binding]; other site 443149002652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149002653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149002654 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443149002655 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443149002656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149002657 ATP binding site [chemical binding]; other site 443149002658 putative Mg++ binding site [ion binding]; other site 443149002659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149002660 nucleotide binding region [chemical binding]; other site 443149002661 ATP-binding site [chemical binding]; other site 443149002662 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443149002663 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 443149002664 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443149002665 homodimer interface [polypeptide binding]; other site 443149002666 metal binding site [ion binding]; metal-binding site 443149002667 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 443149002668 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443149002669 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149002670 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149002671 enolase; Provisional; Region: eno; PRK00077 443149002672 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443149002673 dimer interface [polypeptide binding]; other site 443149002674 metal binding site [ion binding]; metal-binding site 443149002675 substrate binding pocket [chemical binding]; other site 443149002676 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 443149002677 Septum formation initiator; Region: DivIC; pfam04977 443149002678 Uncharacterized conserved protein [Function unknown]; Region: COG1507 443149002679 exopolyphosphatase; Region: exo_poly_only; TIGR03706 443149002680 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 443149002681 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443149002682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002683 active site 443149002684 phosphorylation site [posttranslational modification] 443149002685 intermolecular recognition site; other site 443149002686 dimerization interface [polypeptide binding]; other site 443149002687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002688 DNA binding site [nucleotide binding] 443149002689 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 443149002690 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 443149002691 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 443149002692 Ligand Binding Site [chemical binding]; other site 443149002693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002694 dimer interface [polypeptide binding]; other site 443149002695 phosphorylation site [posttranslational modification] 443149002696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002697 ATP binding site [chemical binding]; other site 443149002698 Mg2+ binding site [ion binding]; other site 443149002699 G-X-G motif; other site 443149002700 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 443149002701 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 443149002702 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149002703 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149002704 K+-transporting ATPase, c chain; Region: KdpC; cl00944 443149002705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149002706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149002707 dimer interface [polypeptide binding]; other site 443149002708 phosphorylation site [posttranslational modification] 443149002709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149002710 ATP binding site [chemical binding]; other site 443149002711 Mg2+ binding site [ion binding]; other site 443149002712 G-X-G motif; other site 443149002713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149002714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149002715 active site 443149002716 phosphorylation site [posttranslational modification] 443149002717 intermolecular recognition site; other site 443149002718 dimerization interface [polypeptide binding]; other site 443149002719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149002720 DNA binding site [nucleotide binding] 443149002721 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149002722 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443149002723 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149002724 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002725 PPE family; Region: PPE; pfam00823 443149002726 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149002727 PE family; Region: PE; pfam00934 443149002728 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149002729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443149002730 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443149002731 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443149002732 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149002733 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149002734 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149002735 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149002736 MULE transposase domain; Region: MULE; pfam10551 443149002737 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149002738 MarR family; Region: MarR_2; pfam12802 443149002739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149002740 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149002741 NAD(P) binding site [chemical binding]; other site 443149002742 active site 443149002743 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443149002744 Helix-turn-helix domain; Region: HTH_17; pfam12728 443149002745 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149002746 Domain of unknown function (DUF427); Region: DUF427; cl00998 443149002747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149002748 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149002749 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443149002750 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 443149002751 dimer interface [polypeptide binding]; other site 443149002752 acyl-activating enzyme (AAE) consensus motif; other site 443149002753 putative active site [active] 443149002754 AMP binding site [chemical binding]; other site 443149002755 putative CoA binding site [chemical binding]; other site 443149002756 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 443149002757 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443149002758 hydrophobic ligand binding site; other site 443149002759 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 443149002760 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443149002761 putative active site [active] 443149002762 putative dimer interface [polypeptide binding]; other site 443149002763 Patatin-like phospholipase; Region: Patatin; pfam01734 443149002764 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149002765 nucleophile elbow; other site 443149002766 hypothetical protein; Provisional; Region: PRK10279 443149002767 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 443149002768 active site 443149002769 nucleophile elbow; other site 443149002770 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 443149002771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443149002772 active site residue [active] 443149002773 PE family; Region: PE; pfam00934 443149002774 PE family; Region: PE; pfam00934 443149002775 Predicted membrane protein [Function unknown]; Region: COG4425 443149002776 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443149002777 enoyl-CoA hydratase; Provisional; Region: PRK05862 443149002778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002779 substrate binding site [chemical binding]; other site 443149002780 oxyanion hole (OAH) forming residues; other site 443149002781 trimer interface [polypeptide binding]; other site 443149002782 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 443149002783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002784 substrate binding site [chemical binding]; other site 443149002785 oxyanion hole (OAH) forming residues; other site 443149002786 trimer interface [polypeptide binding]; other site 443149002787 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 443149002788 Predicted membrane protein [Function unknown]; Region: COG4760 443149002789 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149002790 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149002791 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 443149002792 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149002793 dimer interface [polypeptide binding]; other site 443149002794 active site 443149002795 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443149002796 active site 443149002797 catalytic triad [active] 443149002798 oxyanion hole [active] 443149002799 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149002800 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149002801 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443149002802 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149002803 dimer interface [polypeptide binding]; other site 443149002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002805 catalytic residue [active] 443149002806 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443149002807 RDD family; Region: RDD; pfam06271 443149002808 cystathionine gamma-synthase; Provisional; Region: PRK07811 443149002809 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149002810 homodimer interface [polypeptide binding]; other site 443149002811 substrate-cofactor binding pocket; other site 443149002812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149002813 catalytic residue [active] 443149002814 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443149002815 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443149002816 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443149002817 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443149002818 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 443149002819 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443149002820 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443149002821 catalytic residues [active] 443149002822 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 443149002823 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 443149002824 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 443149002825 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443149002826 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443149002827 catalytic residue [active] 443149002828 putative FPP diphosphate binding site; other site 443149002829 putative FPP binding hydrophobic cleft; other site 443149002830 dimer interface [polypeptide binding]; other site 443149002831 putative IPP diphosphate binding site; other site 443149002832 PE family; Region: PE; pfam00934 443149002833 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443149002834 putative IPP diphosphate binding site; other site 443149002835 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 443149002836 PE family; Region: PE; pfam00934 443149002837 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 443149002838 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 443149002839 ATP-binding site [chemical binding]; other site 443149002840 CoA-binding site [chemical binding]; other site 443149002841 Mg2+-binding site [ion binding]; other site 443149002842 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443149002843 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443149002844 dimer interface [polypeptide binding]; other site 443149002845 active site 443149002846 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443149002847 folate binding site [chemical binding]; other site 443149002848 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443149002849 dinuclear metal binding motif [ion binding]; other site 443149002850 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443149002851 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443149002852 putative active site [active] 443149002853 PhoH-like protein; Region: PhoH; pfam02562 443149002854 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443149002855 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 443149002856 NodB motif; other site 443149002857 active site 443149002858 metal binding site [ion binding]; metal-binding site 443149002859 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 443149002860 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443149002861 Class II fumarases; Region: Fumarase_classII; cd01362 443149002862 active site 443149002863 tetramer interface [polypeptide binding]; other site 443149002864 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443149002865 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 443149002866 putative active site [active] 443149002867 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443149002868 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443149002869 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443149002870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149002871 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443149002872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149002873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149002874 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 443149002875 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 443149002876 putative NAD(P) binding site [chemical binding]; other site 443149002877 active site 443149002878 putative substrate binding site [chemical binding]; other site 443149002879 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 443149002880 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443149002881 generic binding surface II; other site 443149002882 generic binding surface I; other site 443149002883 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443149002884 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443149002885 Yip1 domain; Region: Yip1; pfam04893 443149002886 GTP-binding protein YchF; Reviewed; Region: PRK09601 443149002887 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149002888 G3 box; other site 443149002889 Switch II region; other site 443149002890 GTP/Mg2+ binding site [chemical binding]; other site 443149002891 G4 box; other site 443149002892 G5 box; other site 443149002893 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 443149002894 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443149002895 putative active site [active] 443149002896 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149002897 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149002898 cyclase homology domain; Region: CHD; cd07302 443149002899 nucleotidyl binding site; other site 443149002900 metal binding site [ion binding]; metal-binding site 443149002901 dimer interface [polypeptide binding]; other site 443149002902 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 443149002903 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443149002904 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443149002905 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149002906 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 443149002907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149002908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149002909 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149002910 pyruvate phosphate dikinase; Provisional; Region: PRK05878 443149002911 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443149002912 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 443149002913 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149002914 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149002915 active site 443149002916 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149002917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149002918 sequence-specific DNA binding site [nucleotide binding]; other site 443149002919 salt bridge; other site 443149002920 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443149002921 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443149002922 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443149002923 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 443149002924 citrate synthase; Provisional; Region: PRK14033 443149002925 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 443149002926 oxalacetate binding site [chemical binding]; other site 443149002927 citrylCoA binding site [chemical binding]; other site 443149002928 coenzyme A binding site [chemical binding]; other site 443149002929 catalytic triad [active] 443149002930 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443149002931 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443149002932 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443149002933 THF binding site; other site 443149002934 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443149002935 substrate binding site [chemical binding]; other site 443149002936 THF binding site; other site 443149002937 zinc-binding site [ion binding]; other site 443149002938 putative transposase OrfB; Reviewed; Region: PHA02517 443149002939 HTH-like domain; Region: HTH_21; pfam13276 443149002940 Integrase core domain; Region: rve; pfam00665 443149002941 Integrase core domain; Region: rve_3; pfam13683 443149002942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149002943 Transposase; Region: HTH_Tnp_1; cl17663 443149002944 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149002945 PPE family; Region: PPE; pfam00823 443149002946 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149002947 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 443149002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 443149002949 CAAX protease self-immunity; Region: Abi; pfam02517 443149002950 enoyl-CoA hydratase; Provisional; Region: PRK06688 443149002951 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443149002952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002953 trimer interface [polypeptide binding]; other site 443149002954 enoyl-CoA hydratase; Provisional; Region: PRK06688 443149002955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149002956 substrate binding site [chemical binding]; other site 443149002957 oxyanion hole (OAH) forming residues; other site 443149002958 trimer interface [polypeptide binding]; other site 443149002959 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149002960 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149002961 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 443149002962 NAD binding site [chemical binding]; other site 443149002963 homodimer interface [polypeptide binding]; other site 443149002964 homotetramer interface [polypeptide binding]; other site 443149002965 active site 443149002966 MMPL family; Region: MMPL; pfam03176 443149002967 MMPL family; Region: MMPL; pfam03176 443149002968 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149002969 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149002970 active site 443149002971 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 443149002972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 443149002973 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 443149002974 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 443149002975 NAD-dependent deacetylase; Provisional; Region: PRK00481 443149002976 NAD+ binding site [chemical binding]; other site 443149002977 substrate binding site [chemical binding]; other site 443149002978 Zn binding site [ion binding]; other site 443149002979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149002980 DNA-binding site [nucleotide binding]; DNA binding site 443149002981 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149002982 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 443149002983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 443149002984 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149002985 uncharacterized HhH-GPD family protein; Region: TIGR03252 443149002986 minor groove reading motif; other site 443149002987 helix-hairpin-helix signature motif; other site 443149002988 mannosyltransferase; Provisional; Region: pimE; PRK13375 443149002989 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443149002990 active site 443149002991 8-oxo-dGMP binding site [chemical binding]; other site 443149002992 nudix motif; other site 443149002993 metal binding site [ion binding]; metal-binding site 443149002994 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443149002995 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443149002996 [4Fe-4S] binding site [ion binding]; other site 443149002997 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149002998 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149002999 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003000 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443149003001 molybdopterin cofactor binding site; other site 443149003002 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443149003003 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 443149003004 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443149003005 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 443149003006 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443149003007 G1 box; other site 443149003008 putative GEF interaction site [polypeptide binding]; other site 443149003009 GTP/Mg2+ binding site [chemical binding]; other site 443149003010 Switch I region; other site 443149003011 G2 box; other site 443149003012 G3 box; other site 443149003013 Switch II region; other site 443149003014 G4 box; other site 443149003015 G5 box; other site 443149003016 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443149003017 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443149003018 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149003019 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443149003020 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443149003021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149003022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003023 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003024 PPE family; Region: PPE; pfam00823 443149003025 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003026 PE family; Region: PE; pfam00934 443149003027 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 443149003028 PE family; Region: PE; pfam00934 443149003029 FO synthase; Reviewed; Region: fbiC; PRK09234 443149003030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149003031 FeS/SAM binding site; other site 443149003032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149003033 FeS/SAM binding site; other site 443149003034 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443149003035 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443149003036 active site 443149003037 FMN binding site [chemical binding]; other site 443149003038 2,4-decadienoyl-CoA binding site; other site 443149003039 catalytic residue [active] 443149003040 4Fe-4S cluster binding site [ion binding]; other site 443149003041 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 443149003042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149003043 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149003044 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149003045 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443149003046 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 443149003047 4Fe-4S binding domain; Region: Fer4; pfam00037 443149003048 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 443149003049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149003050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003051 homodimer interface [polypeptide binding]; other site 443149003052 catalytic residue [active] 443149003053 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149003054 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443149003055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149003056 ATP binding site [chemical binding]; other site 443149003057 putative Mg++ binding site [ion binding]; other site 443149003058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443149003059 ATP-binding site [chemical binding]; other site 443149003060 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149003061 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149003062 active site 443149003063 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149003064 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149003065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003066 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149003067 Enoylreductase; Region: PKS_ER; smart00829 443149003068 NAD(P) binding site [chemical binding]; other site 443149003069 KR domain; Region: KR; pfam08659 443149003070 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149003071 putative NADP binding site [chemical binding]; other site 443149003072 active site 443149003073 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149003074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149003075 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149003076 PE-PPE domain; Region: PE-PPE; pfam08237 443149003077 acyl-CoA synthetase; Validated; Region: PRK05850 443149003078 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149003079 acyl-activating enzyme (AAE) consensus motif; other site 443149003080 active site 443149003081 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003082 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003083 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 443149003084 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 443149003085 Glutamate binding site [chemical binding]; other site 443149003086 NAD binding site [chemical binding]; other site 443149003087 catalytic residues [active] 443149003088 Proline dehydrogenase; Region: Pro_dh; pfam01619 443149003089 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443149003090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149003091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149003092 DNA binding residues [nucleotide binding] 443149003093 haloalkane dehalogenase; Provisional; Region: PRK03204 443149003094 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149003095 catalytic site [active] 443149003096 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149003097 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 443149003098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149003099 PGAP1-like protein; Region: PGAP1; pfam07819 443149003100 acyl-CoA synthetase; Validated; Region: PRK07787 443149003101 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149003102 acyl-activating enzyme (AAE) consensus motif; other site 443149003103 AMP binding site [chemical binding]; other site 443149003104 active site 443149003105 CoA binding site [chemical binding]; other site 443149003106 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003107 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003108 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003109 PPE family; Region: PPE; pfam00823 443149003110 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003111 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149003112 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149003113 MULE transposase domain; Region: MULE; pfam10551 443149003114 metabolite-proton symporter; Region: 2A0106; TIGR00883 443149003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003116 putative substrate translocation pore; other site 443149003117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443149003118 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443149003119 putative trimer interface [polypeptide binding]; other site 443149003120 putative CoA binding site [chemical binding]; other site 443149003121 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 443149003122 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443149003123 metal binding site [ion binding]; metal-binding site 443149003124 putative dimer interface [polypeptide binding]; other site 443149003125 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443149003126 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 443149003127 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 443149003128 acyl-activating enzyme (AAE) consensus motif; other site 443149003129 putative AMP binding site [chemical binding]; other site 443149003130 putative active site [active] 443149003131 putative CoA binding site [chemical binding]; other site 443149003132 dihydropteroate synthase; Region: DHPS; TIGR01496 443149003133 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443149003134 substrate binding pocket [chemical binding]; other site 443149003135 dimer interface [polypeptide binding]; other site 443149003136 inhibitor binding site; inhibition site 443149003137 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 443149003138 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149003139 DivIVA domain; Region: DivI1A_domain; TIGR03544 443149003140 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 443149003141 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443149003142 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149003143 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443149003144 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443149003145 ligand binding site; other site 443149003146 oligomer interface; other site 443149003147 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443149003148 dimer interface [polypeptide binding]; other site 443149003149 N-terminal domain interface [polypeptide binding]; other site 443149003150 sulfate 1 binding site; other site 443149003151 PE family; Region: PE; pfam00934 443149003152 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443149003153 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443149003154 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443149003155 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 443149003156 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149003157 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149003158 Walker A/P-loop; other site 443149003159 ATP binding site [chemical binding]; other site 443149003160 Q-loop/lid; other site 443149003161 ABC transporter signature motif; other site 443149003162 Walker B; other site 443149003163 D-loop; other site 443149003164 H-loop/switch region; other site 443149003165 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443149003166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003167 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443149003168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003169 S-adenosylmethionine binding site [chemical binding]; other site 443149003170 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 443149003171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149003172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149003173 DNA binding residues [nucleotide binding] 443149003174 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443149003175 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149003176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443149003177 protein binding site [polypeptide binding]; other site 443149003178 sec-independent translocase; Provisional; Region: PRK03100 443149003179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149003180 Predicted membrane protein [Function unknown]; Region: COG3428 443149003181 Bacterial PH domain; Region: DUF304; pfam03703 443149003182 Uncharacterized conserved protein [Function unknown]; Region: COG3402 443149003183 Domain of unknown function DUF59; Region: DUF59; cl00941 443149003184 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443149003185 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 443149003186 Walker A motif; other site 443149003187 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443149003188 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149003189 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149003190 catalytic residue [active] 443149003191 Predicted membrane protein [Function unknown]; Region: COG4420 443149003192 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443149003193 MgtE intracellular N domain; Region: MgtE_N; smart00924 443149003194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443149003195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443149003196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149003197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003198 dimer interface [polypeptide binding]; other site 443149003199 conserved gate region; other site 443149003200 putative PBP binding loops; other site 443149003201 ABC-ATPase subunit interface; other site 443149003202 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149003203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003204 dimer interface [polypeptide binding]; other site 443149003205 conserved gate region; other site 443149003206 ABC-ATPase subunit interface; other site 443149003207 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149003208 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149003209 Walker A/P-loop; other site 443149003210 ATP binding site [chemical binding]; other site 443149003211 Q-loop/lid; other site 443149003212 ABC transporter signature motif; other site 443149003213 Walker B; other site 443149003214 D-loop; other site 443149003215 H-loop/switch region; other site 443149003216 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443149003217 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 443149003218 oligomer interface [polypeptide binding]; other site 443149003219 metal binding site [ion binding]; metal-binding site 443149003220 metal binding site [ion binding]; metal-binding site 443149003221 putative Cl binding site [ion binding]; other site 443149003222 basic sphincter; other site 443149003223 hydrophobic gate; other site 443149003224 periplasmic entrance; other site 443149003225 malate dehydrogenase; Provisional; Region: PRK05442 443149003226 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 443149003227 NAD(P) binding site [chemical binding]; other site 443149003228 dimer interface [polypeptide binding]; other site 443149003229 malate binding site [chemical binding]; other site 443149003230 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149003231 PE family; Region: PE; pfam00934 443149003232 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 443149003233 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443149003234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003235 NAD(P) binding site [chemical binding]; other site 443149003236 active site 443149003237 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443149003238 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149003239 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443149003240 TPP-binding site [chemical binding]; other site 443149003241 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443149003242 dimer interface [polypeptide binding]; other site 443149003243 PYR/PP interface [polypeptide binding]; other site 443149003244 TPP binding site [chemical binding]; other site 443149003245 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 443149003246 RNase_H superfamily; Region: RNase_H_2; pfam13482 443149003247 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 443149003248 Part of AAA domain; Region: AAA_19; pfam13245 443149003249 AAA domain; Region: AAA_12; pfam13087 443149003250 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443149003251 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443149003252 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443149003253 ATP binding site [chemical binding]; other site 443149003254 Mg++ binding site [ion binding]; other site 443149003255 motif III; other site 443149003256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149003257 nucleotide binding region [chemical binding]; other site 443149003258 ATP-binding site [chemical binding]; other site 443149003259 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 443149003260 putative RNA binding site [nucleotide binding]; other site 443149003261 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443149003262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149003263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003264 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149003265 FAD binding domain; Region: FAD_binding_4; pfam01565 443149003266 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443149003267 potential frameshift: common BLAST hit: gi|383307132|ref|YP_005359943.1| membrane transporter 443149003268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 443149003269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003270 putative substrate translocation pore; other site 443149003271 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 443149003272 Fe-S cluster binding site [ion binding]; other site 443149003273 DNA binding site [nucleotide binding] 443149003274 active site 443149003275 hypothetical protein; Validated; Region: PRK05868 443149003276 hypothetical protein; Provisional; Region: PRK07236 443149003277 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149003278 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149003279 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443149003280 HIT family signature motif; other site 443149003281 catalytic residue [active] 443149003282 amidase; Provisional; Region: PRK12470 443149003283 Amidase; Region: Amidase; pfam01425 443149003284 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003285 cyclase homology domain; Region: CHD; cd07302 443149003286 nucleotidyl binding site; other site 443149003287 metal binding site [ion binding]; metal-binding site 443149003288 dimer interface [polypeptide binding]; other site 443149003289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149003290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149003291 active site 443149003292 ATP binding site [chemical binding]; other site 443149003293 substrate binding site [chemical binding]; other site 443149003294 activation loop (A-loop); other site 443149003295 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149003296 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149003297 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149003298 DNA binding site [nucleotide binding] 443149003299 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149003300 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149003301 phosphopeptide binding site; other site 443149003302 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 443149003303 putative active site [active] 443149003304 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149003305 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149003306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149003307 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 443149003308 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443149003309 Walker A/P-loop; other site 443149003310 ATP binding site [chemical binding]; other site 443149003311 Q-loop/lid; other site 443149003312 ABC transporter signature motif; other site 443149003313 Walker B; other site 443149003314 D-loop; other site 443149003315 H-loop/switch region; other site 443149003316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443149003317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443149003318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003319 Walker A/P-loop; other site 443149003320 ATP binding site [chemical binding]; other site 443149003321 Q-loop/lid; other site 443149003322 ABC transporter signature motif; other site 443149003323 Walker B; other site 443149003324 D-loop; other site 443149003325 H-loop/switch region; other site 443149003326 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149003327 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149003328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149003329 catalytic core [active] 443149003330 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 443149003331 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443149003332 active site 443149003333 metal binding site [ion binding]; metal-binding site 443149003334 DNA binding site [nucleotide binding] 443149003335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003336 Walker A/P-loop; other site 443149003337 ATP binding site [chemical binding]; other site 443149003338 choline dehydrogenase; Validated; Region: PRK02106 443149003339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149003340 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149003341 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149003342 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443149003343 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 443149003344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149003345 Walker A/P-loop; other site 443149003346 ATP binding site [chemical binding]; other site 443149003347 Q-loop/lid; other site 443149003348 ABC transporter signature motif; other site 443149003349 Walker B; other site 443149003350 D-loop; other site 443149003351 H-loop/switch region; other site 443149003352 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443149003353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149003354 Walker A/P-loop; other site 443149003355 ATP binding site [chemical binding]; other site 443149003356 Q-loop/lid; other site 443149003357 ABC transporter signature motif; other site 443149003358 Walker B; other site 443149003359 D-loop; other site 443149003360 H-loop/switch region; other site 443149003361 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443149003362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443149003363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003364 dimer interface [polypeptide binding]; other site 443149003365 conserved gate region; other site 443149003366 putative PBP binding loops; other site 443149003367 ABC-ATPase subunit interface; other site 443149003368 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 443149003369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149003370 dimer interface [polypeptide binding]; other site 443149003371 conserved gate region; other site 443149003372 putative PBP binding loops; other site 443149003373 ABC-ATPase subunit interface; other site 443149003374 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 443149003375 active site clefts [active] 443149003376 zinc binding site [ion binding]; other site 443149003377 dimer interface [polypeptide binding]; other site 443149003378 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443149003379 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443149003380 Active Sites [active] 443149003381 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 443149003382 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443149003383 CysD dimerization site [polypeptide binding]; other site 443149003384 G1 box; other site 443149003385 putative GEF interaction site [polypeptide binding]; other site 443149003386 GTP/Mg2+ binding site [chemical binding]; other site 443149003387 Switch I region; other site 443149003388 G2 box; other site 443149003389 G3 box; other site 443149003390 Switch II region; other site 443149003391 G4 box; other site 443149003392 G5 box; other site 443149003393 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443149003394 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443149003395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003396 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 443149003397 Walker A/P-loop; other site 443149003398 ligand-binding site [chemical binding]; other site 443149003399 ATP binding site [chemical binding]; other site 443149003400 Rrf2 family protein; Region: rrf2_super; TIGR00738 443149003401 Transcriptional regulator; Region: Rrf2; pfam02082 443149003402 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003403 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443149003404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443149003406 Putative esterase; Region: Esterase; pfam00756 443149003407 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 443149003408 Predicted membrane protein [Function unknown]; Region: COG4325 443149003409 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 443149003410 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149003411 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443149003412 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443149003413 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443149003414 active site 443149003415 HIGH motif; other site 443149003416 KMSK motif region; other site 443149003417 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 443149003418 tRNA binding surface [nucleotide binding]; other site 443149003419 anticodon binding site; other site 443149003420 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443149003421 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443149003422 active site 443149003423 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149003424 substrate binding site [chemical binding]; other site 443149003425 catalytic residues [active] 443149003426 dimer interface [polypeptide binding]; other site 443149003427 homoserine dehydrogenase; Provisional; Region: PRK06349 443149003428 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443149003429 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443149003430 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443149003431 threonine synthase; Reviewed; Region: PRK06721 443149003432 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443149003433 homodimer interface [polypeptide binding]; other site 443149003434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003435 catalytic residue [active] 443149003436 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 443149003437 transcription termination factor Rho; Provisional; Region: PRK12678 443149003438 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 443149003439 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443149003440 RNA binding site [nucleotide binding]; other site 443149003441 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443149003442 multimer interface [polypeptide binding]; other site 443149003443 Walker A motif; other site 443149003444 ATP binding site [chemical binding]; other site 443149003445 Walker B motif; other site 443149003446 peptide chain release factor 1; Region: prfA; TIGR00019 443149003447 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443149003448 RF-1 domain; Region: RF-1; pfam00472 443149003449 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443149003450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003451 S-adenosylmethionine binding site [chemical binding]; other site 443149003452 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443149003453 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443149003454 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443149003455 Mg++ binding site [ion binding]; other site 443149003456 putative catalytic motif [active] 443149003457 substrate binding site [chemical binding]; other site 443149003458 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 443149003459 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443149003460 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443149003461 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443149003462 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 443149003463 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443149003464 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 443149003465 potential frameshift: common BLAST hit: gi|378771071|ref|YP_005170804.1| ATP synthase subunit alpha 443149003466 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443149003467 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149003468 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149003469 Walker A motif; other site 443149003470 ATP binding site [chemical binding]; other site 443149003471 Walker B motif; other site 443149003472 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443149003473 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443149003474 core domain interface [polypeptide binding]; other site 443149003475 delta subunit interface [polypeptide binding]; other site 443149003476 epsilon subunit interface [polypeptide binding]; other site 443149003477 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443149003478 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443149003479 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443149003480 alpha subunit interaction interface [polypeptide binding]; other site 443149003481 Walker A motif; other site 443149003482 ATP binding site [chemical binding]; other site 443149003483 Walker B motif; other site 443149003484 inhibitor binding site; inhibition site 443149003485 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443149003486 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 443149003487 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443149003488 gamma subunit interface [polypeptide binding]; other site 443149003489 epsilon subunit interface [polypeptide binding]; other site 443149003490 LBP interface [polypeptide binding]; other site 443149003491 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 443149003492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149003493 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149003494 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 443149003495 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443149003496 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443149003497 hinge; other site 443149003498 active site 443149003499 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 443149003500 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443149003501 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443149003502 DNA binding site [nucleotide binding] 443149003503 active site 443149003504 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 443149003505 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 443149003506 AlkA N-terminal domain; Region: AlkA_N; pfam06029 443149003507 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443149003508 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149003509 minor groove reading motif; other site 443149003510 helix-hairpin-helix signature motif; other site 443149003511 substrate binding pocket [chemical binding]; other site 443149003512 active site 443149003513 HAMP domain; Region: HAMP; pfam00672 443149003514 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003515 cyclase homology domain; Region: CHD; cd07302 443149003516 nucleotidyl binding site; other site 443149003517 metal binding site [ion binding]; metal-binding site 443149003518 dimer interface [polypeptide binding]; other site 443149003519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003520 dimerization interface [polypeptide binding]; other site 443149003521 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003522 cyclase homology domain; Region: CHD; cd07302 443149003523 nucleotidyl binding site; other site 443149003524 metal binding site [ion binding]; metal-binding site 443149003525 dimer interface [polypeptide binding]; other site 443149003526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003527 dimerization interface [polypeptide binding]; other site 443149003528 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003529 cyclase homology domain; Region: CHD; cd07302 443149003530 nucleotidyl binding site; other site 443149003531 metal binding site [ion binding]; metal-binding site 443149003532 dimer interface [polypeptide binding]; other site 443149003533 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 443149003534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149003535 dimerization interface [polypeptide binding]; other site 443149003536 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003537 cyclase homology domain; Region: CHD; cd07302 443149003538 nucleotidyl binding site; other site 443149003539 metal binding site [ion binding]; metal-binding site 443149003540 dimer interface [polypeptide binding]; other site 443149003541 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 443149003542 hypothetical protein; Provisional; Region: PRK03298 443149003543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149003544 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443149003545 dimer interface [polypeptide binding]; other site 443149003546 substrate binding site [chemical binding]; other site 443149003547 metal binding site [ion binding]; metal-binding site 443149003548 putative acyltransferase; Provisional; Region: PRK05790 443149003549 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149003550 dimer interface [polypeptide binding]; other site 443149003551 active site 443149003552 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443149003553 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 443149003554 PE family; Region: PE; pfam00934 443149003555 glycogen branching enzyme; Provisional; Region: PRK05402 443149003556 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443149003557 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443149003558 active site 443149003559 catalytic site [active] 443149003560 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443149003561 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443149003562 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443149003563 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443149003564 active site 443149003565 homodimer interface [polypeptide binding]; other site 443149003566 catalytic site [active] 443149003567 acceptor binding site [chemical binding]; other site 443149003568 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443149003569 putative homodimer interface [polypeptide binding]; other site 443149003570 putative active site pocket [active] 443149003571 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443149003572 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443149003573 DEAD/DEAH box helicase; Region: DEAD; pfam00270 443149003574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443149003575 putative Mg++ binding site [ion binding]; other site 443149003576 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 443149003577 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443149003578 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443149003579 active site 443149003580 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443149003581 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443149003582 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443149003583 putative active site pocket [active] 443149003584 cleavage site 443149003585 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 443149003586 MPN+ (JAMM) motif; other site 443149003587 Zinc-binding site [ion binding]; other site 443149003588 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149003589 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149003590 dimer interface [polypeptide binding]; other site 443149003591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149003592 catalytic residue [active] 443149003593 Rhomboid family; Region: Rhomboid; cl11446 443149003594 glutamate racemase; Provisional; Region: PRK00865 443149003595 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443149003596 ribonuclease PH; Reviewed; Region: rph; PRK00173 443149003597 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443149003598 hexamer interface [polypeptide binding]; other site 443149003599 active site 443149003600 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443149003601 active site 443149003602 dimerization interface [polypeptide binding]; other site 443149003603 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443149003604 Glucitol operon activator [Transcription]; Region: GutM; COG4578 443149003605 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 443149003606 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149003607 acyl-activating enzyme (AAE) consensus motif; other site 443149003608 active site 443149003609 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149003610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149003611 active site 443149003612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 443149003613 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 443149003614 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443149003615 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443149003616 FAD binding pocket [chemical binding]; other site 443149003617 FAD binding motif [chemical binding]; other site 443149003618 phosphate binding motif [ion binding]; other site 443149003619 NAD binding pocket [chemical binding]; other site 443149003620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003621 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443149003622 Walker A/P-loop; other site 443149003623 ATP binding site [chemical binding]; other site 443149003624 Q-loop/lid; other site 443149003625 ABC transporter signature motif; other site 443149003626 Walker B; other site 443149003627 D-loop; other site 443149003628 H-loop/switch region; other site 443149003629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149003631 Walker A/P-loop; other site 443149003632 ATP binding site [chemical binding]; other site 443149003633 Q-loop/lid; other site 443149003634 ABC transporter signature motif; other site 443149003635 Walker B; other site 443149003636 D-loop; other site 443149003637 H-loop/switch region; other site 443149003638 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443149003639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149003640 NAD(P) binding site [chemical binding]; other site 443149003641 active site 443149003642 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443149003643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149003644 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443149003645 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149003646 GAF domain; Region: GAF; pfam01590 443149003647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 443149003648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 443149003649 metal binding site [ion binding]; metal-binding site 443149003650 active site 443149003651 I-site; other site 443149003652 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443149003653 hypothetical protein; Provisional; Region: PRK07877 443149003654 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443149003655 ATP binding site [chemical binding]; other site 443149003656 substrate interface [chemical binding]; other site 443149003657 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149003658 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 443149003659 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003660 cyclase homology domain; Region: CHD; cd07302 443149003661 nucleotidyl binding site; other site 443149003662 dimer interface [polypeptide binding]; other site 443149003663 metal binding site [ion binding]; metal-binding site 443149003664 AAA ATPase domain; Region: AAA_16; pfam13191 443149003665 Predicted ATPase [General function prediction only]; Region: COG3903 443149003666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149003667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149003668 DNA binding residues [nucleotide binding] 443149003669 dimerization interface [polypeptide binding]; other site 443149003670 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149003671 cyclase homology domain; Region: CHD; cd07302 443149003672 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443149003673 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149003674 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003675 PPE family; Region: PPE; pfam00823 443149003676 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149003677 PAS fold; Region: PAS_4; pfam08448 443149003678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443149003679 putative active site [active] 443149003680 heme pocket [chemical binding]; other site 443149003681 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443149003682 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443149003683 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443149003684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443149003685 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149003686 anti sigma factor interaction site; other site 443149003687 regulatory phosphorylation site [posttranslational modification]; other site 443149003688 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149003689 anti sigma factor interaction site; other site 443149003690 regulatory phosphorylation site [posttranslational modification]; other site 443149003691 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443149003692 synthetase active site [active] 443149003693 NTP binding site [chemical binding]; other site 443149003694 metal binding site [ion binding]; metal-binding site 443149003695 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149003696 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149003697 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149003698 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 443149003699 putative transposase OrfB; Reviewed; Region: PHA02517 443149003700 HTH-like domain; Region: HTH_21; pfam13276 443149003701 Integrase core domain; Region: rve; pfam00665 443149003702 Integrase core domain; Region: rve_3; pfam13683 443149003703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149003704 Transposase; Region: HTH_Tnp_1; cl17663 443149003705 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443149003706 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149003707 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149003708 malonyl-CoA binding site [chemical binding]; other site 443149003709 dimer interface [polypeptide binding]; other site 443149003710 active site 443149003711 product binding site; other site 443149003712 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443149003713 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443149003714 uncharacterized domain; Region: TIGR00702 443149003715 YcaO-like family; Region: YcaO; pfam02624 443149003716 Uncharacterized conserved protein [Function unknown]; Region: COG3482 443149003717 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149003718 active site 443149003719 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 443149003720 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443149003721 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443149003722 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443149003723 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443149003724 dihydroorotase; Validated; Region: pyrC; PRK09357 443149003725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149003726 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443149003727 active site 443149003728 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443149003729 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443149003730 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443149003731 catalytic site [active] 443149003732 subunit interface [polypeptide binding]; other site 443149003733 potential frameshift: common BLAST hit: gi|383307253|ref|YP_005360064.1| carbamoyl phosphate synthase large subunit 443149003734 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149003735 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 443149003736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149003737 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443149003738 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 443149003739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149003740 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149003741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149003742 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443149003743 IMP binding site; other site 443149003744 dimer interface [polypeptide binding]; other site 443149003745 interdomain contacts; other site 443149003746 partial ornithine binding site; other site 443149003747 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443149003748 active site 443149003749 dimer interface [polypeptide binding]; other site 443149003750 PE family; Region: PE; pfam00934 443149003751 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149003752 PPE family; Region: PPE; pfam00823 443149003753 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443149003754 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443149003755 catalytic site [active] 443149003756 G-X2-G-X-G-K; other site 443149003757 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 443149003758 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443149003759 Flavoprotein; Region: Flavoprotein; pfam02441 443149003760 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443149003761 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443149003762 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443149003763 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443149003764 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443149003765 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149003766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149003767 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149003768 Cytochrome P450; Region: p450; cl12078 443149003769 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149003770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149003771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149003772 PE family; Region: PE; pfam00934 443149003773 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149003774 oligomeric interface; other site 443149003775 putative active site [active] 443149003776 homodimer interface [polypeptide binding]; other site 443149003777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149003779 substrate binding pocket [chemical binding]; other site 443149003780 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149003781 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149003782 substrate binding pocket [chemical binding]; other site 443149003783 Predicted membrane protein [Function unknown]; Region: COG3714 443149003784 primosome assembly protein PriA; Provisional; Region: PRK14873 443149003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003786 S-adenosylmethionine binding site [chemical binding]; other site 443149003787 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149003788 MarR family; Region: MarR; pfam01047 443149003789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149003790 S-adenosylmethionine binding site [chemical binding]; other site 443149003791 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443149003792 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443149003793 putative active site [active] 443149003794 substrate binding site [chemical binding]; other site 443149003795 putative cosubstrate binding site; other site 443149003796 catalytic site [active] 443149003797 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443149003798 substrate binding site [chemical binding]; other site 443149003799 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 443149003800 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 443149003801 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 443149003802 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443149003803 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 443149003804 substrate binding site [chemical binding]; other site 443149003805 hexamer interface [polypeptide binding]; other site 443149003806 metal binding site [ion binding]; metal-binding site 443149003807 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443149003808 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443149003809 catalytic motif [active] 443149003810 Zn binding site [ion binding]; other site 443149003811 RibD C-terminal domain; Region: RibD_C; pfam01872 443149003812 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149003813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149003814 putative substrate translocation pore; other site 443149003815 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149003816 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443149003817 Lumazine binding domain; Region: Lum_binding; pfam00677 443149003818 Lumazine binding domain; Region: Lum_binding; pfam00677 443149003819 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149003820 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443149003821 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443149003822 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149003823 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443149003824 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443149003825 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443149003826 dimerization interface [polypeptide binding]; other site 443149003827 active site 443149003828 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443149003829 homopentamer interface [polypeptide binding]; other site 443149003830 active site 443149003831 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149003832 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149003833 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 443149003834 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 443149003835 putative sugar binding sites [chemical binding]; other site 443149003836 Q-X-W motif; other site 443149003837 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443149003838 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443149003839 active site 443149003840 GIY-YIG motif/motif A; other site 443149003841 catalytic site [active] 443149003842 putative DNA binding site [nucleotide binding]; other site 443149003843 metal binding site [ion binding]; metal-binding site 443149003844 UvrB/uvrC motif; Region: UVR; pfam02151 443149003845 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443149003846 Helix-hairpin-helix motif; Region: HHH; pfam00633 443149003847 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 443149003848 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 443149003849 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 443149003850 phosphate binding site [ion binding]; other site 443149003851 putative substrate binding pocket [chemical binding]; other site 443149003852 dimer interface [polypeptide binding]; other site 443149003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443149003854 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443149003855 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149003856 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149003857 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149003858 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149003859 acyl-CoA synthetase; Provisional; Region: PRK13382 443149003860 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 443149003861 acyl-activating enzyme (AAE) consensus motif; other site 443149003862 putative AMP binding site [chemical binding]; other site 443149003863 putative active site [active] 443149003864 putative CoA binding site [chemical binding]; other site 443149003865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149003866 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149003867 putative acyl-acceptor binding pocket; other site 443149003868 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003869 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003870 PE family; Region: PE; pfam00934 443149003871 PE-PPE domain; Region: PE-PPE; pfam08237 443149003872 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443149003873 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149003874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149003875 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149003876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149003877 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149003878 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443149003879 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 443149003880 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443149003881 Phosphoglycerate kinase; Region: PGK; pfam00162 443149003882 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443149003883 substrate binding site [chemical binding]; other site 443149003884 hinge regions; other site 443149003885 ADP binding site [chemical binding]; other site 443149003886 catalytic site [active] 443149003887 triosephosphate isomerase; Provisional; Region: PRK14567 443149003888 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443149003889 substrate binding site [chemical binding]; other site 443149003890 dimer interface [polypeptide binding]; other site 443149003891 catalytic triad [active] 443149003892 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149003893 PE family; Region: PE; pfam00934 443149003894 potential frameshift: common BLAST hit: gi|378771206|ref|YP_005170939.1| putative biotin sulfoxide reductase 443149003895 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003896 molybdopterin cofactor binding site; other site 443149003897 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149003898 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 443149003899 molybdopterin cofactor binding site; other site 443149003900 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443149003901 hydrophobic ligand binding site; other site 443149003902 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443149003903 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 443149003904 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443149003905 putative active site [active] 443149003906 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 443149003907 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 443149003908 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443149003909 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443149003910 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443149003911 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443149003912 putative active site [active] 443149003913 transaldolase; Provisional; Region: PRK03903 443149003914 catalytic residue [active] 443149003915 transketolase; Region: PLN02790 443149003916 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443149003917 TPP-binding site [chemical binding]; other site 443149003918 dimer interface [polypeptide binding]; other site 443149003919 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149003920 PYR/PP interface [polypeptide binding]; other site 443149003921 dimer interface [polypeptide binding]; other site 443149003922 TPP binding site [chemical binding]; other site 443149003923 PE family; Region: PE; pfam00934 443149003924 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 443149003925 UbiA prenyltransferase family; Region: UbiA; pfam01040 443149003926 PE family; Region: PE; pfam00934 443149003927 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149003928 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149003929 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443149003930 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443149003931 NADP binding site [chemical binding]; other site 443149003932 dimer interface [polypeptide binding]; other site 443149003933 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149003934 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 443149003935 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149003936 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149003937 Walker A/P-loop; other site 443149003938 ATP binding site [chemical binding]; other site 443149003939 Q-loop/lid; other site 443149003940 ABC transporter signature motif; other site 443149003941 Walker B; other site 443149003942 D-loop; other site 443149003943 H-loop/switch region; other site 443149003944 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443149003945 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 443149003946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 443149003947 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443149003948 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149003949 protein-splicing catalytic site; other site 443149003950 thioester formation/cholesterol transfer; other site 443149003951 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 443149003952 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443149003953 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443149003954 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 443149003955 FeS assembly protein SufD; Region: sufD; TIGR01981 443149003956 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 443149003957 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 443149003958 Walker A/P-loop; other site 443149003959 ATP binding site [chemical binding]; other site 443149003960 Q-loop/lid; other site 443149003961 ABC transporter signature motif; other site 443149003962 Walker B; other site 443149003963 D-loop; other site 443149003964 H-loop/switch region; other site 443149003965 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149003966 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443149003967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149003968 catalytic residue [active] 443149003969 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443149003970 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443149003971 trimerization site [polypeptide binding]; other site 443149003972 active site 443149003973 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 443149003974 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443149003975 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443149003976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149003977 active site 443149003978 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443149003979 PE family; Region: PE; pfam00934 443149003980 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443149003981 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149003982 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149003983 catalytic residues [active] 443149003984 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149003985 catalytic residues [active] 443149003986 enoyl-CoA hydratase; Provisional; Region: PRK05864 443149003987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149003988 substrate binding site [chemical binding]; other site 443149003989 oxyanion hole (OAH) forming residues; other site 443149003990 trimer interface [polypeptide binding]; other site 443149003991 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443149003992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149003993 Walker A/P-loop; other site 443149003994 ATP binding site [chemical binding]; other site 443149003995 Q-loop/lid; other site 443149003996 ABC transporter signature motif; other site 443149003997 Walker B; other site 443149003998 D-loop; other site 443149003999 H-loop/switch region; other site 443149004000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004003 aconitate hydratase; Validated; Region: PRK09277 443149004004 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443149004005 substrate binding site [chemical binding]; other site 443149004006 ligand binding site [chemical binding]; other site 443149004007 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443149004008 substrate binding site [chemical binding]; other site 443149004009 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004010 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004011 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004012 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004013 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149004014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149004015 Walker A motif; other site 443149004016 ATP binding site [chemical binding]; other site 443149004017 Walker B motif; other site 443149004018 arginine finger; other site 443149004019 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149004020 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149004021 hypothetical protein; Provisional; Region: PRK13685 443149004022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 443149004023 metal ion-dependent adhesion site (MIDAS); other site 443149004024 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149004025 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443149004026 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443149004027 NAD(P) binding site [chemical binding]; other site 443149004028 homotetramer interface [polypeptide binding]; other site 443149004029 homodimer interface [polypeptide binding]; other site 443149004030 active site 443149004031 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 443149004032 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 443149004033 NAD binding site [chemical binding]; other site 443149004034 homotetramer interface [polypeptide binding]; other site 443149004035 homodimer interface [polypeptide binding]; other site 443149004036 substrate binding site [chemical binding]; other site 443149004037 active site 443149004038 ferrochelatase; Reviewed; Region: hemH; PRK00035 443149004039 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443149004040 C-terminal domain interface [polypeptide binding]; other site 443149004041 active site 443149004042 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443149004043 active site 443149004044 N-terminal domain interface [polypeptide binding]; other site 443149004045 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 443149004046 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443149004047 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443149004048 Uncharacterized conserved protein [Function unknown]; Region: COG0398 443149004049 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443149004050 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 443149004051 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 443149004052 heterodimer interface [polypeptide binding]; other site 443149004053 substrate interaction site [chemical binding]; other site 443149004054 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 443149004055 potential frameshift: common BLAST hit: gi|378771259|ref|YP_005170992.1| methylmalonyl-CoA mutase 443149004056 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 443149004057 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 443149004058 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443149004059 B12 binding site [chemical binding]; other site 443149004060 cobalt ligand [ion binding]; other site 443149004061 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149004062 membrane ATPase/protein kinase; Provisional; Region: PRK09435 443149004063 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443149004064 Walker A; other site 443149004065 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149004066 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149004067 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149004068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004069 S-adenosylmethionine binding site [chemical binding]; other site 443149004070 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 443149004071 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 443149004072 Ligand binding site; other site 443149004073 Putative Catalytic site; other site 443149004074 DXD motif; other site 443149004075 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443149004076 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443149004077 active site 443149004078 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443149004079 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149004080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149004081 catalytic residue [active] 443149004082 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 443149004083 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 443149004084 putative trimer interface [polypeptide binding]; other site 443149004085 putative CoA binding site [chemical binding]; other site 443149004086 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443149004087 S-adenosylmethionine binding site [chemical binding]; other site 443149004088 WbqC-like protein family; Region: WbqC; pfam08889 443149004089 potential frameshift: common BLAST hit: gi|375296682|ref|YP_005100949.1| membrane protein 443149004090 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443149004091 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149004092 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443149004093 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443149004094 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443149004095 NADP-binding site; other site 443149004096 homotetramer interface [polypeptide binding]; other site 443149004097 substrate binding site [chemical binding]; other site 443149004098 homodimer interface [polypeptide binding]; other site 443149004099 active site 443149004100 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443149004101 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443149004102 NADP binding site [chemical binding]; other site 443149004103 active site 443149004104 putative substrate binding site [chemical binding]; other site 443149004105 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443149004106 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443149004107 metal-binding site 443149004108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004109 S-adenosylmethionine binding site [chemical binding]; other site 443149004110 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149004112 active site 443149004113 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149004114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004115 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 443149004116 active site 443149004117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149004118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149004119 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149004120 active site 443149004121 acyl-CoA synthetase; Validated; Region: PRK05850 443149004122 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149004123 acyl-activating enzyme (AAE) consensus motif; other site 443149004124 active site 443149004125 Transport protein; Region: actII; TIGR00833 443149004126 MMPL family; Region: MMPL; pfam03176 443149004127 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149004128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004129 S-adenosylmethionine binding site [chemical binding]; other site 443149004130 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149004131 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149004132 homodimer interface [polypeptide binding]; other site 443149004133 active site 443149004134 TDP-binding site; other site 443149004135 acceptor substrate-binding pocket; other site 443149004136 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149004137 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149004138 Probable Catalytic site; other site 443149004139 metal-binding site 443149004140 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149004141 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149004142 active site 443149004143 TDP-binding site; other site 443149004144 acceptor substrate-binding pocket; other site 443149004145 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004147 active site 443149004148 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149004149 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004151 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004152 Enoylreductase; Region: PKS_ER; smart00829 443149004153 NAD(P) binding site [chemical binding]; other site 443149004154 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149004155 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004156 putative NADP binding site [chemical binding]; other site 443149004157 active site 443149004158 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004159 acyl-CoA synthetase; Validated; Region: PRK05850 443149004160 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149004161 acyl-activating enzyme (AAE) consensus motif; other site 443149004162 active site 443149004163 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149004164 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149004165 NAD(P) binding site [chemical binding]; other site 443149004166 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149004167 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 443149004168 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149004169 CoenzymeA binding site [chemical binding]; other site 443149004170 subunit interaction site [polypeptide binding]; other site 443149004171 PHB binding site; other site 443149004172 Nitronate monooxygenase; Region: NMO; pfam03060 443149004173 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149004174 FMN binding site [chemical binding]; other site 443149004175 substrate binding site [chemical binding]; other site 443149004176 putative catalytic residue [active] 443149004177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004178 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 443149004179 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443149004180 HIGH motif; other site 443149004181 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443149004182 active site 443149004183 KMSKS motif; other site 443149004184 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443149004185 tRNA binding surface [nucleotide binding]; other site 443149004186 anticodon binding site; other site 443149004187 DNA polymerase IV; Provisional; Region: PRK03348 443149004188 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443149004189 active site 443149004190 DNA binding site [nucleotide binding] 443149004191 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 443149004192 active site 443149004193 homodimer interface [polypeptide binding]; other site 443149004194 homotetramer interface [polypeptide binding]; other site 443149004195 lipoprotein signal peptidase; Provisional; Region: PRK14764 443149004196 lipoprotein signal peptidase; Provisional; Region: PRK14787 443149004197 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443149004198 active site 443149004199 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 443149004200 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 443149004201 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 443149004202 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443149004203 apolar tunnel; other site 443149004204 heme binding site [chemical binding]; other site 443149004205 dimerization interface [polypeptide binding]; other site 443149004206 short chain dehydrogenase; Provisional; Region: PRK05866 443149004207 classical (c) SDRs; Region: SDR_c; cd05233 443149004208 NAD(P) binding site [chemical binding]; other site 443149004209 active site 443149004210 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149004211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004212 NAD(P) binding site [chemical binding]; other site 443149004213 active site 443149004214 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443149004215 hydrophobic ligand binding site; other site 443149004216 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443149004217 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443149004218 active site 443149004219 PHP Thumb interface [polypeptide binding]; other site 443149004220 metal binding site [ion binding]; metal-binding site 443149004221 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443149004222 generic binding surface II; other site 443149004223 generic binding surface I; other site 443149004224 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004225 PPE family; Region: PPE; pfam00823 443149004226 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004227 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004229 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149004230 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443149004231 acyl-activating enzyme (AAE) consensus motif; other site 443149004232 putative AMP binding site [chemical binding]; other site 443149004233 putative active site [active] 443149004234 putative CoA binding site [chemical binding]; other site 443149004235 potential frameshift: common BLAST hit: gi|383307406|ref|YP_005360217.1| glycerol-3-phosphate acyltransferase 443149004236 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443149004237 putative acyl-acceptor binding pocket; other site 443149004238 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 443149004239 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 443149004240 L-aspartate oxidase; Provisional; Region: PRK06175 443149004241 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149004242 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 443149004243 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443149004244 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 443149004245 D-subunit interface [polypeptide binding]; other site 443149004246 Iron-sulfur protein interface; other site 443149004247 proximal quinone binding site [chemical binding]; other site 443149004248 distal quinone binding site [chemical binding]; other site 443149004249 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 443149004250 Iron-sulfur protein interface; other site 443149004251 proximal quinone binding site [chemical binding]; other site 443149004252 C-subunit interface; other site 443149004253 distal quinone binding site; other site 443149004254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004256 MMPL family; Region: MMPL; pfam03176 443149004257 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149004258 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443149004259 threonine dehydratase; Validated; Region: PRK08639 443149004260 tetramer interface [polypeptide binding]; other site 443149004261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004262 catalytic residue [active] 443149004263 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 443149004264 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149004265 putative active site [active] 443149004266 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443149004267 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443149004268 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443149004269 catalytic site [active] 443149004270 active site 443149004271 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443149004272 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 443149004273 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443149004274 active site 443149004275 catalytic site [active] 443149004276 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443149004277 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443149004278 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443149004279 active site 443149004280 catalytic site [active] 443149004281 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443149004282 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149004283 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149004284 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 443149004285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149004286 inhibitor-cofactor binding pocket; inhibition site 443149004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004288 catalytic residue [active] 443149004289 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 443149004290 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 443149004291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149004292 catalytic residue [active] 443149004293 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443149004294 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443149004295 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149004297 active site 443149004298 biotin synthase; Validated; Region: PRK06256 443149004299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149004300 FeS/SAM binding site; other site 443149004301 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 443149004302 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 443149004303 Secretory lipase; Region: LIP; pfam03583 443149004304 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 443149004305 quinolinate synthetase; Provisional; Region: PRK09375 443149004306 L-aspartate oxidase; Provisional; Region: PRK07804 443149004307 L-aspartate oxidase; Provisional; Region: PRK06175 443149004308 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149004309 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 443149004310 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443149004311 dimerization interface [polypeptide binding]; other site 443149004312 active site 443149004313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004314 S-adenosylmethionine binding site [chemical binding]; other site 443149004315 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 443149004316 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 443149004317 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443149004318 NAD binding site [chemical binding]; other site 443149004319 dimerization interface [polypeptide binding]; other site 443149004320 product binding site; other site 443149004321 substrate binding site [chemical binding]; other site 443149004322 zinc binding site [ion binding]; other site 443149004323 catalytic residues [active] 443149004324 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443149004325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149004326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004327 homodimer interface [polypeptide binding]; other site 443149004328 catalytic residue [active] 443149004329 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443149004330 4-fold oligomerization interface [polypeptide binding]; other site 443149004331 putative active site pocket [active] 443149004332 metal binding residues [ion binding]; metal-binding site 443149004333 3-fold/trimer interface [polypeptide binding]; other site 443149004334 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443149004335 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443149004336 putative active site [active] 443149004337 oxyanion strand; other site 443149004338 catalytic triad [active] 443149004339 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443149004340 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443149004341 catalytic residues [active] 443149004342 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 443149004343 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149004344 active site 443149004345 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443149004346 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443149004347 substrate binding site [chemical binding]; other site 443149004348 glutamase interaction surface [polypeptide binding]; other site 443149004349 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443149004350 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 443149004351 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443149004352 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149004353 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443149004354 catalytic triad [active] 443149004355 anthranilate synthase component I; Provisional; Region: PRK13571 443149004356 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443149004357 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149004358 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 443149004359 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443149004360 active site 443149004361 ribulose/triose binding site [chemical binding]; other site 443149004362 phosphate binding site [ion binding]; other site 443149004363 substrate (anthranilate) binding pocket [chemical binding]; other site 443149004364 product (indole) binding pocket [chemical binding]; other site 443149004365 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443149004366 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443149004367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004368 catalytic residue [active] 443149004369 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443149004370 substrate binding site [chemical binding]; other site 443149004371 active site 443149004372 catalytic residues [active] 443149004373 heterodimer interface [polypeptide binding]; other site 443149004374 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 443149004375 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 443149004376 TM2 domain; Region: TM2; pfam05154 443149004377 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443149004378 pyruvate kinase; Provisional; Region: PRK06247 443149004379 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443149004380 active site 443149004381 domain interfaces; other site 443149004382 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443149004383 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443149004384 active site 443149004385 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443149004386 catalytic triad [active] 443149004387 dimer interface [polypeptide binding]; other site 443149004388 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443149004389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149004390 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 443149004391 Walker A/P-loop; other site 443149004392 Walker A/P-loop; other site 443149004393 ATP binding site [chemical binding]; other site 443149004394 ATP binding site [chemical binding]; other site 443149004395 Q-loop/lid; other site 443149004396 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 443149004397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149004398 Walker A/P-loop; other site 443149004399 ATP binding site [chemical binding]; other site 443149004400 Q-loop/lid; other site 443149004401 ABC transporter signature motif; other site 443149004402 Walker B; other site 443149004403 D-loop; other site 443149004404 H-loop/switch region; other site 443149004405 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443149004406 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443149004407 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443149004408 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 443149004409 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443149004410 cyclase homology domain; Region: CHD; cd07302 443149004411 nucleotidyl binding site; other site 443149004412 metal binding site [ion binding]; metal-binding site 443149004413 dimer interface [polypeptide binding]; other site 443149004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149004415 active site 443149004416 phosphorylation site [posttranslational modification] 443149004417 intermolecular recognition site; other site 443149004418 lipid-transfer protein; Provisional; Region: PRK06059 443149004419 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149004420 active site 443149004421 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149004422 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443149004423 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149004424 DNA polymerase I; Provisional; Region: PRK05755 443149004425 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443149004426 active site 443149004427 metal binding site 1 [ion binding]; metal-binding site 443149004428 putative 5' ssDNA interaction site; other site 443149004429 metal binding site 3; metal-binding site 443149004430 metal binding site 2 [ion binding]; metal-binding site 443149004431 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443149004432 putative DNA binding site [nucleotide binding]; other site 443149004433 putative metal binding site [ion binding]; other site 443149004434 3'-5' exonuclease; Region: 35EXOc; smart00474 443149004435 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443149004436 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443149004437 active site 443149004438 DNA binding site [nucleotide binding] 443149004439 catalytic site [active] 443149004440 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443149004441 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443149004442 RNA binding site [nucleotide binding]; other site 443149004443 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443149004444 RNA binding site [nucleotide binding]; other site 443149004445 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443149004446 RNA binding site [nucleotide binding]; other site 443149004447 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 443149004448 RNA binding site [nucleotide binding]; other site 443149004449 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 443149004450 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443149004451 CoA-binding site [chemical binding]; other site 443149004452 ATP-binding [chemical binding]; other site 443149004453 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 443149004454 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 443149004455 excinuclease ABC subunit B; Provisional; Region: PRK05298 443149004456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149004457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149004458 nucleotide binding region [chemical binding]; other site 443149004459 ATP-binding site [chemical binding]; other site 443149004460 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443149004461 UvrB/uvrC motif; Region: UVR; pfam02151 443149004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149004463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149004464 putative substrate translocation pore; other site 443149004465 Predicted membrane protein [Function unknown]; Region: COG5305 443149004466 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149004467 Ligand Binding Site [chemical binding]; other site 443149004468 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149004469 potential frameshift: common BLAST hit: gi|383307476|ref|YP_005360287.1| excinuclease ABC subunit A 443149004470 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443149004471 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443149004472 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443149004473 Predicted esterase [General function prediction only]; Region: COG0627 443149004474 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 443149004475 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443149004476 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443149004477 dimer interface [polypeptide binding]; other site 443149004478 putative anticodon binding site; other site 443149004479 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149004480 motif 1; other site 443149004481 dimer interface [polypeptide binding]; other site 443149004482 active site 443149004483 motif 2; other site 443149004484 motif 3; other site 443149004485 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443149004486 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443149004487 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443149004488 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443149004489 23S rRNA binding site [nucleotide binding]; other site 443149004490 L21 binding site [polypeptide binding]; other site 443149004491 L13 binding site [polypeptide binding]; other site 443149004492 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149004493 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149004495 PE family; Region: PE; pfam00934 443149004496 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149004497 cyclase homology domain; Region: CHD; cd07302 443149004498 nucleotidyl binding site; other site 443149004499 metal binding site [ion binding]; metal-binding site 443149004500 dimer interface [polypeptide binding]; other site 443149004501 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443149004502 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443149004503 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443149004504 dimer interface [polypeptide binding]; other site 443149004505 motif 1; other site 443149004506 active site 443149004507 motif 2; other site 443149004508 motif 3; other site 443149004509 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443149004510 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443149004511 putative tRNA-binding site [nucleotide binding]; other site 443149004512 B3/4 domain; Region: B3_4; pfam03483 443149004513 tRNA synthetase B5 domain; Region: B5; smart00874 443149004514 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149004515 motif 2; other site 443149004516 active site 443149004517 motif 3; other site 443149004518 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443149004519 PE family; Region: PE; pfam00934 443149004520 potential frameshift: common BLAST hit: gi|383307487|ref|YP_005360298.1| N-acetyl-gamma-glutamyl-phosphate reductase 443149004521 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149004522 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 443149004523 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443149004524 heterotetramer interface [polypeptide binding]; other site 443149004525 active site pocket [active] 443149004526 cleavage site 443149004527 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443149004528 feedback inhibition sensing region; other site 443149004529 homohexameric interface [polypeptide binding]; other site 443149004530 nucleotide binding site [chemical binding]; other site 443149004531 N-acetyl-L-glutamate binding site [chemical binding]; other site 443149004532 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443149004533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149004534 inhibitor-cofactor binding pocket; inhibition site 443149004535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149004536 catalytic residue [active] 443149004537 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443149004538 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443149004539 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443149004540 arginine repressor; Provisional; Region: PRK03341 443149004541 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 443149004542 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 443149004543 argininosuccinate synthase; Provisional; Region: PRK13820 443149004544 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443149004545 ANP binding site [chemical binding]; other site 443149004546 Substrate Binding Site II [chemical binding]; other site 443149004547 Substrate Binding Site I [chemical binding]; other site 443149004548 argininosuccinate lyase; Provisional; Region: PRK00855 443149004549 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443149004550 active sites [active] 443149004551 tetramer interface [polypeptide binding]; other site 443149004552 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149004553 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149004554 malonyl-CoA binding site [chemical binding]; other site 443149004555 dimer interface [polypeptide binding]; other site 443149004556 active site 443149004557 product binding site; other site 443149004558 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004559 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004560 active site 443149004561 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004562 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004564 Enoylreductase; Region: PKS_ER; smart00829 443149004565 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004566 NAD(P) binding site [chemical binding]; other site 443149004567 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149004568 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004569 putative NADP binding site [chemical binding]; other site 443149004570 active site 443149004571 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004572 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149004573 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004574 active site 443149004575 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004576 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149004577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149004578 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149004579 Enoylreductase; Region: PKS_ER; smart00829 443149004580 NAD(P) binding site [chemical binding]; other site 443149004581 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149004582 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149004583 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149004584 putative NADP binding site [chemical binding]; other site 443149004585 active site 443149004586 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004587 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149004588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149004589 active site 443149004590 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149004591 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149004592 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149004593 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443149004594 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443149004595 malonyl-CoA binding site [chemical binding]; other site 443149004596 dimer interface [polypeptide binding]; other site 443149004597 active site 443149004598 product binding site; other site 443149004599 Cytochrome P450; Region: p450; cl12078 443149004600 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149004601 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443149004602 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004603 ABC transporter; Region: ABC_tran_2; pfam12848 443149004604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149004605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 443149004606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149004607 putative substrate translocation pore; other site 443149004608 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149004609 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149004610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149004611 dimerization interface [polypeptide binding]; other site 443149004612 putative DNA binding site [nucleotide binding]; other site 443149004613 putative Zn2+ binding site [ion binding]; other site 443149004614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443149004615 active site residue [active] 443149004616 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149004617 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149004618 ligand binding site [chemical binding]; other site 443149004619 flexible hinge region; other site 443149004620 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 443149004621 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443149004622 putative catalytic residues [active] 443149004623 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443149004624 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149004625 catalytic residues [active] 443149004626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149004627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149004628 active site 443149004629 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 443149004630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443149004631 substrate binding pocket [chemical binding]; other site 443149004632 membrane-bound complex binding site; other site 443149004633 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 443149004634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149004635 FeS/SAM binding site; other site 443149004636 DivIVA protein; Region: DivIVA; pfam05103 443149004637 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443149004638 acyl-CoA synthetase; Validated; Region: PRK07868 443149004639 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 443149004640 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004642 acyl-activating enzyme (AAE) consensus motif; other site 443149004643 AMP binding site [chemical binding]; other site 443149004644 active site 443149004645 CoA binding site [chemical binding]; other site 443149004646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004647 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149004648 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149004649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149004650 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443149004651 Walker A/P-loop; other site 443149004652 ATP binding site [chemical binding]; other site 443149004653 Q-loop/lid; other site 443149004654 ABC transporter signature motif; other site 443149004655 Walker B; other site 443149004656 D-loop; other site 443149004657 H-loop/switch region; other site 443149004658 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443149004659 active site 443149004660 DNA binding site [nucleotide binding] 443149004661 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443149004662 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443149004663 active site 443149004664 HIGH motif; other site 443149004665 dimer interface [polypeptide binding]; other site 443149004666 KMSKS motif; other site 443149004667 S4 RNA-binding domain; Region: S4; smart00363 443149004668 RNA binding surface [nucleotide binding]; other site 443149004669 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149004670 Tetratrico peptide repeat; Region: TPR_5; pfam12688 443149004671 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443149004672 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 443149004673 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149004674 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443149004675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149004676 RNA binding surface [nucleotide binding]; other site 443149004677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004678 S-adenosylmethionine binding site [chemical binding]; other site 443149004679 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 443149004680 ATP-NAD kinase; Region: NAD_kinase; pfam01513 443149004681 DNA repair protein RecN; Region: recN; TIGR00634 443149004682 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443149004683 Walker A/P-loop; other site 443149004684 ATP binding site [chemical binding]; other site 443149004685 Q-loop/lid; other site 443149004686 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443149004687 ABC transporter signature motif; other site 443149004688 Walker B; other site 443149004689 D-loop; other site 443149004690 H-loop/switch region; other site 443149004691 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 443149004692 Thiamine pyrophosphokinase; Region: TPK; cl08415 443149004693 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 443149004694 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 443149004695 CTP synthetase; Validated; Region: pyrG; PRK05380 443149004696 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443149004697 Catalytic site [active] 443149004698 active site 443149004699 UTP binding site [chemical binding]; other site 443149004700 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443149004701 active site 443149004702 putative oxyanion hole; other site 443149004703 catalytic triad [active] 443149004704 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443149004705 dimer interface [polypeptide binding]; other site 443149004706 ADP-ribose binding site [chemical binding]; other site 443149004707 active site 443149004708 nudix motif; other site 443149004709 metal binding site [ion binding]; metal-binding site 443149004710 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443149004711 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149004712 active site 443149004713 DNA binding site [nucleotide binding] 443149004714 Int/Topo IB signature motif; other site 443149004715 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004716 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149004717 active site 443149004718 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149004719 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443149004720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149004721 S-adenosylmethionine binding site [chemical binding]; other site 443149004722 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 443149004723 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004724 PPE family; Region: PPE; pfam00823 443149004725 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004726 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004727 PPE family; Region: PPE; pfam00823 443149004728 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004729 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149004730 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149004731 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443149004732 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149004733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149004734 P-loop; other site 443149004735 Magnesium ion binding site [ion binding]; other site 443149004736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149004737 Magnesium ion binding site [ion binding]; other site 443149004738 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 443149004739 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 443149004740 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443149004741 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149004742 RNA binding surface [nucleotide binding]; other site 443149004743 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443149004744 active site 443149004745 cytidylate kinase; Provisional; Region: cmk; PRK00023 443149004746 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443149004747 CMP-binding site; other site 443149004748 The sites determining sugar specificity; other site 443149004749 GTP-binding protein Der; Reviewed; Region: PRK03003 443149004750 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443149004751 GTP/Mg2+ binding site [chemical binding]; other site 443149004752 Switch I region; other site 443149004753 G2 box; other site 443149004754 Switch II region; other site 443149004755 G3 box; other site 443149004756 G4 box; other site 443149004757 G5 box; other site 443149004758 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443149004759 G1 box; other site 443149004760 GTP/Mg2+ binding site [chemical binding]; other site 443149004761 Switch I region; other site 443149004762 G2 box; other site 443149004763 G3 box; other site 443149004764 Switch II region; other site 443149004765 G4 box; other site 443149004766 G5 box; other site 443149004767 short chain dehydrogenase; Provisional; Region: PRK06841 443149004768 classical (c) SDRs; Region: SDR_c; cd05233 443149004769 NAD(P) binding site [chemical binding]; other site 443149004770 active site 443149004771 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443149004772 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443149004773 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443149004774 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 443149004775 Cupin domain; Region: Cupin_2; pfam07883 443149004776 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 443149004777 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149004778 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443149004779 putative switch regulator; other site 443149004780 non-specific DNA interactions [nucleotide binding]; other site 443149004781 DNA binding site [nucleotide binding] 443149004782 sequence specific DNA binding site [nucleotide binding]; other site 443149004783 putative cAMP binding site [chemical binding]; other site 443149004784 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149004785 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 443149004786 putative active site [active] 443149004787 homotetrameric interface [polypeptide binding]; other site 443149004788 metal binding site [ion binding]; metal-binding site 443149004789 biotin carboxylase-like protein; Validated; Region: PRK06524 443149004790 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149004791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149004792 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149004793 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149004794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149004795 dimerization interface [polypeptide binding]; other site 443149004796 putative DNA binding site [nucleotide binding]; other site 443149004797 putative Zn2+ binding site [ion binding]; other site 443149004798 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149004799 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149004800 FAD binding domain; Region: FAD_binding_4; pfam01565 443149004801 Berberine and berberine like; Region: BBE; pfam08031 443149004802 TIGR03086 family protein; Region: TIGR03086 443149004803 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149004804 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149004805 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149004806 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149004807 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149004808 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 443149004809 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443149004810 NAD(P) binding site [chemical binding]; other site 443149004811 catalytic residues [active] 443149004812 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 443149004813 putative catalytic residue [active] 443149004814 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 443149004815 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 443149004816 gating phenylalanine in ion channel; other site 443149004817 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443149004818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149004819 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 443149004820 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 443149004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149004822 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 443149004823 putative substrate translocation pore; other site 443149004824 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443149004825 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149004826 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443149004827 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149004828 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443149004829 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 443149004830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149004831 active site 443149004832 ATP binding site [chemical binding]; other site 443149004833 substrate binding site [chemical binding]; other site 443149004834 activation loop (A-loop); other site 443149004835 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 443149004836 Thioredoxin; Region: Thioredoxin_4; cl17273 443149004837 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 443149004838 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443149004839 active site 443149004840 metal binding site [ion binding]; metal-binding site 443149004841 nudix motif; other site 443149004842 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149004843 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149004844 active site 443149004845 ATP binding site [chemical binding]; other site 443149004846 substrate binding site [chemical binding]; other site 443149004847 activation loop (A-loop); other site 443149004848 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149004849 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149004850 phosphopeptide binding site; other site 443149004851 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 443149004852 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 443149004853 Walker A/P-loop; other site 443149004854 ATP binding site [chemical binding]; other site 443149004855 Q-loop/lid; other site 443149004856 ABC transporter signature motif; other site 443149004857 Walker B; other site 443149004858 D-loop; other site 443149004859 H-loop/switch region; other site 443149004860 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443149004861 acyl-CoA synthetase; Provisional; Region: PRK13388 443149004862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149004863 acyl-activating enzyme (AAE) consensus motif; other site 443149004864 AMP binding site [chemical binding]; other site 443149004865 active site 443149004866 CoA binding site [chemical binding]; other site 443149004867 hypothetical protein; Provisional; Region: PRK06185 443149004868 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149004869 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443149004870 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443149004871 potential frameshift: common BLAST hit: gi|339631806|ref|YP_004723448.1| PPE family protein 443149004872 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004873 PPE family; Region: PPE; pfam00823 443149004874 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004875 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004876 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149004877 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443149004878 putative transposase OrfB; Reviewed; Region: PHA02517 443149004879 HTH-like domain; Region: HTH_21; pfam13276 443149004880 Integrase core domain; Region: rve; pfam00665 443149004881 Integrase core domain; Region: rve_3; pfam13683 443149004882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149004883 Transposase; Region: HTH_Tnp_1; cl17663 443149004884 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 443149004885 PE family; Region: PE; pfam00934 443149004886 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443149004887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 443149004888 dimer interface [polypeptide binding]; other site 443149004889 active site 443149004890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149004891 substrate binding site [chemical binding]; other site 443149004892 catalytic residue [active] 443149004893 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443149004894 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443149004895 metal binding site [ion binding]; metal-binding site 443149004896 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443149004897 FAD binding domain; Region: FAD_binding_4; pfam01565 443149004898 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443149004899 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443149004900 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149004901 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149004902 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149004903 FAD binding domain; Region: FAD_binding_4; pfam01565 443149004904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149004906 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149004907 Cytochrome P450; Region: p450; cl12078 443149004908 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 443149004909 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 443149004910 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 443149004911 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149004912 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149004913 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149004914 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149004915 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149004916 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149004917 Cytochrome P450; Region: p450; cl12078 443149004918 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004919 PPE family; Region: PPE; pfam00823 443149004920 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004921 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004922 PPE family; Region: PPE; pfam00823 443149004923 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004924 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004925 PPE family; Region: PPE; pfam00823 443149004926 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004927 EspG family; Region: ESX-1_EspG; pfam14011 443149004928 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149004929 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 443149004930 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149004931 catalytic residues [active] 443149004932 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149004933 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 443149004934 active site 443149004935 catalytic residues [active] 443149004936 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149004937 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149004938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149004939 Walker A motif; other site 443149004940 ATP binding site [chemical binding]; other site 443149004941 Walker B motif; other site 443149004942 arginine finger; other site 443149004943 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004944 PPE family; Region: PPE; pfam00823 443149004945 PE-PPE domain; Region: PE-PPE; pfam08237 443149004946 putative transposase OrfB; Reviewed; Region: PHA02517 443149004947 HTH-like domain; Region: HTH_21; pfam13276 443149004948 Integrase core domain; Region: rve; pfam00665 443149004949 Integrase core domain; Region: rve_3; pfam13683 443149004950 Transposase; Region: HTH_Tnp_1; cl17663 443149004951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149004952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149004953 Transposase; Region: HTH_Tnp_1; cl17663 443149004954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149004955 Transposase; Region: HTH_Tnp_1; cl17663 443149004956 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004957 PPE family; Region: PPE; pfam00823 443149004958 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004959 PPE family; Region: PPE; pfam00823 443149004960 potential frameshift: common BLAST hit: gi|15841273|ref|NP_336310.1| PE PGRS family protein 443149004961 PE family; Region: PE; pfam00934 443149004962 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149004963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004964 PPE family; Region: PPE; pfam00823 443149004965 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004966 PPE family; Region: PPE; pfam00823 443149004967 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149004968 PPE family; Region: PPE; pfam00823 443149004969 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149004970 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149004971 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443149004972 MgtC family; Region: MgtC; pfam02308 443149004973 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443149004974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149004975 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 443149004976 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 443149004977 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 443149004978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149004979 hypothetical protein; Validated; Region: PRK07121 443149004980 PE family; Region: PE; pfam00934 443149004981 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 443149004982 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 443149004983 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 443149004984 hypothetical protein; Provisional; Region: PRK05858 443149004985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149004986 PYR/PP interface [polypeptide binding]; other site 443149004987 dimer interface [polypeptide binding]; other site 443149004988 TPP binding site [chemical binding]; other site 443149004989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149004990 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 443149004991 TPP-binding site; other site 443149004992 dimer interface [polypeptide binding]; other site 443149004993 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 443149004994 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 443149004995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 443149004996 nucleotide binding region [chemical binding]; other site 443149004997 ATP-binding site [chemical binding]; other site 443149004998 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149004999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149005000 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149005001 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 443149005002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443149005003 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443149005004 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443149005005 lipoyl attachment site [posttranslational modification]; other site 443149005006 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149005007 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149005008 phosphopeptide binding site; other site 443149005009 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443149005010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149005011 DNA binding residues [nucleotide binding] 443149005012 Bifunctional nuclease; Region: DNase-RNase; pfam02577 443149005013 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 443149005014 DNA binding residues [nucleotide binding] 443149005015 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443149005016 putative dimer interface [polypeptide binding]; other site 443149005017 glycine dehydrogenase; Provisional; Region: PRK05367 443149005018 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443149005019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149005020 tetramer interface [polypeptide binding]; other site 443149005021 catalytic residue [active] 443149005022 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443149005023 tetramer interface [polypeptide binding]; other site 443149005024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149005025 catalytic residue [active] 443149005026 haloalkane dehalogenase; Provisional; Region: PRK03204 443149005027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149005028 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 443149005029 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 443149005030 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149005031 metal ion-dependent adhesion site (MIDAS); other site 443149005032 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 443149005033 active site 443149005034 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149005035 putative active site [active] 443149005036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149005037 FOG: CBS domain [General function prediction only]; Region: COG0517 443149005038 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149005039 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443149005040 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149005041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149005042 Transporter associated domain; Region: CorC_HlyC; smart01091 443149005043 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443149005044 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149005045 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443149005046 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443149005047 active site 443149005048 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443149005049 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443149005050 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443149005051 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 443149005052 Predicted transcriptional regulator [Transcription]; Region: COG3682 443149005053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443149005054 CoenzymeA binding site [chemical binding]; other site 443149005055 subunit interaction site [polypeptide binding]; other site 443149005056 PHB binding site; other site 443149005057 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 443149005058 alpha-gamma subunit interface [polypeptide binding]; other site 443149005059 beta-gamma subunit interface [polypeptide binding]; other site 443149005060 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 443149005061 gamma-beta subunit interface [polypeptide binding]; other site 443149005062 alpha-beta subunit interface [polypeptide binding]; other site 443149005063 urease subunit alpha; Reviewed; Region: ureC; PRK13206 443149005064 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 443149005065 subunit interactions [polypeptide binding]; other site 443149005066 active site 443149005067 flap region; other site 443149005068 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 443149005069 UreF; Region: UreF; pfam01730 443149005070 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149005071 UreD urease accessory protein; Region: UreD; cl00530 443149005072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443149005073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149005074 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443149005075 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149005076 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149005077 classical (c) SDRs; Region: SDR_c; cd05233 443149005078 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 443149005079 NAD(P) binding site [chemical binding]; other site 443149005080 active site 443149005081 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443149005082 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149005083 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443149005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005085 dimer interface [polypeptide binding]; other site 443149005086 conserved gate region; other site 443149005087 putative PBP binding loops; other site 443149005088 ABC-ATPase subunit interface; other site 443149005089 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 443149005090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149005091 Walker A/P-loop; other site 443149005092 ATP binding site [chemical binding]; other site 443149005093 Q-loop/lid; other site 443149005094 ABC transporter signature motif; other site 443149005095 Walker B; other site 443149005096 D-loop; other site 443149005097 H-loop/switch region; other site 443149005098 TOBE domain; Region: TOBE; pfam03459 443149005099 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 443149005100 Predicted membrane protein [Function unknown]; Region: COG2261 443149005101 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 443149005102 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 443149005103 putative NAD(P) binding site [chemical binding]; other site 443149005104 putative substrate binding site [chemical binding]; other site 443149005105 catalytic Zn binding site [ion binding]; other site 443149005106 structural Zn binding site [ion binding]; other site 443149005107 CAAX protease self-immunity; Region: Abi; pfam02517 443149005108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 443149005109 MOSC domain; Region: MOSC; pfam03473 443149005110 short chain dehydrogenase; Provisional; Region: PRK07825 443149005111 classical (c) SDRs; Region: SDR_c; cd05233 443149005112 NAD(P) binding site [chemical binding]; other site 443149005113 active site 443149005114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149005115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149005116 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149005117 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149005118 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 443149005119 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149005120 active site 443149005121 hypothetical protein; Provisional; Region: PRK12320 443149005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005123 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443149005124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149005125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149005126 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149005127 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 443149005128 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 443149005129 active site 443149005130 substrate binding site [chemical binding]; other site 443149005131 FMN binding site [chemical binding]; other site 443149005132 putative catalytic residues [active] 443149005133 Uncharacterized conserved protein [Function unknown]; Region: COG5579 443149005134 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149005135 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443149005136 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443149005137 heme binding site [chemical binding]; other site 443149005138 ferroxidase pore; other site 443149005139 ferroxidase diiron center [ion binding]; other site 443149005140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149005142 putative substrate translocation pore; other site 443149005143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005144 putative substrate translocation pore; other site 443149005145 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 443149005146 23S rRNA interface [nucleotide binding]; other site 443149005147 L3 interface [polypeptide binding]; other site 443149005148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149005149 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149005150 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149005151 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149005152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149005153 Cytochrome P450; Region: p450; cl12078 443149005154 short chain dehydrogenase; Provisional; Region: PRK08267 443149005155 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 443149005156 putative NAD(P) binding site [chemical binding]; other site 443149005157 active site 443149005158 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149005159 hydrophobic ligand binding site; other site 443149005160 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149005161 chorismate mutase; Provisional; Region: PRK09269 443149005162 chorismate mutase, putative; Region: CM_mono2; TIGR01806 443149005163 Putative esterase; Region: Esterase; pfam00756 443149005164 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149005165 Leucine carboxyl methyltransferase; Region: LCM; cl01306 443149005166 YceI-like domain; Region: YceI; cl01001 443149005167 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149005168 FMN binding site [chemical binding]; other site 443149005169 substrate binding site [chemical binding]; other site 443149005170 putative catalytic residue [active] 443149005171 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 443149005172 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149005173 catalytic Zn binding site [ion binding]; other site 443149005174 NAD(P) binding site [chemical binding]; other site 443149005175 structural Zn binding site [ion binding]; other site 443149005176 Leucine carboxyl methyltransferase; Region: LCM; cl01306 443149005177 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443149005178 putative active site [active] 443149005179 dimerization interface [polypeptide binding]; other site 443149005180 putative tRNAtyr binding site [nucleotide binding]; other site 443149005181 Domain of unknown function DUF77; Region: DUF77; pfam01910 443149005182 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 443149005183 putative ADP-ribose binding site [chemical binding]; other site 443149005184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149005185 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149005186 cyclase homology domain; Region: CHD; cd07302 443149005187 nucleotidyl binding site; other site 443149005188 metal binding site [ion binding]; metal-binding site 443149005189 dimer interface [polypeptide binding]; other site 443149005190 potential frameshift: common BLAST hit: gi|383307720|ref|YP_005360531.1| competence damage-inducible protein A 443149005191 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 443149005192 putative MPT binding site; other site 443149005193 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 443149005194 putative sialic acid transporter; Region: 2A0112; TIGR00891 443149005195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149005196 putative substrate translocation pore; other site 443149005197 Predicted membrane protein [Function unknown]; Region: COG1950 443149005198 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149005199 anti sigma factor interaction site; other site 443149005200 regulatory phosphorylation site [posttranslational modification]; other site 443149005201 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443149005202 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 443149005203 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443149005204 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443149005205 dimer interface [polypeptide binding]; other site 443149005206 active site 443149005207 heme binding site [chemical binding]; other site 443149005208 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443149005209 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443149005210 metal binding site 2 [ion binding]; metal-binding site 443149005211 putative DNA binding helix; other site 443149005212 metal binding site 1 [ion binding]; metal-binding site 443149005213 dimer interface [polypeptide binding]; other site 443149005214 structural Zn2+ binding site [ion binding]; other site 443149005215 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149005216 substrate binding site [chemical binding]; other site 443149005217 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149005218 substrate binding site [chemical binding]; other site 443149005219 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149005220 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 443149005221 putative NAD(P) binding site [chemical binding]; other site 443149005222 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149005223 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443149005224 tetramer interface [polypeptide binding]; other site 443149005225 active site 443149005226 Mg2+/Mn2+ binding site [ion binding]; other site 443149005227 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 443149005228 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005229 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005230 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005231 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005232 PPE family; Region: PPE; pfam00823 443149005233 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005234 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005235 PPE family; Region: PPE; pfam00823 443149005236 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005237 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149005238 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149005239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443149005240 putative acyl-acceptor binding pocket; other site 443149005241 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443149005242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005243 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005244 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149005245 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149005246 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 443149005247 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149005248 acyl-activating enzyme (AAE) consensus motif; other site 443149005249 active site 443149005250 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 443149005251 Uncharacterized conserved protein [Function unknown]; Region: COG3361 443149005252 short chain dehydrogenase; Provisional; Region: PRK05867 443149005253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005254 NAD(P) binding site [chemical binding]; other site 443149005255 active site 443149005256 TIGR03085 family protein; Region: TIGR03085 443149005257 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443149005258 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443149005259 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443149005260 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 443149005261 dimer interface [polypeptide binding]; other site 443149005262 catalytic triad [active] 443149005263 peroxidatic and resolving cysteines [active] 443149005264 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149005265 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149005266 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443149005267 active site 443149005268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149005269 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149005270 FAD binding site [chemical binding]; other site 443149005271 substrate binding site [chemical binding]; other site 443149005272 catalytic base [active] 443149005273 enoyl-CoA hydratase; Provisional; Region: PRK08290 443149005274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149005275 substrate binding site [chemical binding]; other site 443149005276 oxyanion hole (OAH) forming residues; other site 443149005277 trimer interface [polypeptide binding]; other site 443149005278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149005279 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149005280 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 443149005281 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149005282 catalytic loop [active] 443149005283 iron binding site [ion binding]; other site 443149005284 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 443149005285 FAD binding pocket [chemical binding]; other site 443149005286 FAD binding motif [chemical binding]; other site 443149005287 phosphate binding motif [ion binding]; other site 443149005288 beta-alpha-beta structure motif; other site 443149005289 NAD binding pocket [chemical binding]; other site 443149005290 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149005291 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149005292 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149005293 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 443149005294 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443149005295 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 443149005296 dimerization interface [polypeptide binding]; other site 443149005297 active site 443149005298 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 443149005299 putative NAD(P) binding site [chemical binding]; other site 443149005300 active site 443149005301 homodimer interface [polypeptide binding]; other site 443149005302 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149005303 SEC-C motif; Region: SEC-C; pfam02810 443149005304 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005305 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005306 active site 443149005307 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 443149005308 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 443149005309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149005310 non-specific DNA binding site [nucleotide binding]; other site 443149005311 salt bridge; other site 443149005312 sequence-specific DNA binding site [nucleotide binding]; other site 443149005313 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149005314 putative active site [active] 443149005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149005317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005318 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149005319 Permease; Region: Permease; pfam02405 443149005320 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149005321 Permease; Region: Permease; pfam02405 443149005322 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005323 mce related protein; Region: MCE; pfam02470 443149005324 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149005325 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005326 mce related protein; Region: MCE; pfam02470 443149005327 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005328 mce related protein; Region: MCE; pfam02470 443149005329 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005330 mce related protein; Region: MCE; pfam02470 443149005331 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005332 mce related protein; Region: MCE; pfam02470 443149005333 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149005334 mce related protein; Region: MCE; pfam02470 443149005335 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149005336 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 443149005337 YacP-like NYN domain; Region: NYN_YacP; cl01491 443149005338 PE family; Region: PE; pfam00934 443149005339 Peptidase family M48; Region: Peptidase_M48; pfam01435 443149005340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005341 S-adenosylmethionine binding site [chemical binding]; other site 443149005342 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149005343 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443149005344 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443149005345 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443149005346 dimer interface [polypeptide binding]; other site 443149005347 putative radical transfer pathway; other site 443149005348 diiron center [ion binding]; other site 443149005349 tyrosyl radical; other site 443149005350 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149005351 putative active site [active] 443149005352 PE family; Region: PE; pfam00934 443149005353 Cutinase; Region: Cutinase; pfam01083 443149005354 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 443149005355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149005356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443149005357 dimerization interface [polypeptide binding]; other site 443149005358 Lysine efflux permease [General function prediction only]; Region: COG1279 443149005359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005360 S-adenosylmethionine binding site [chemical binding]; other site 443149005361 Uncharacterized conserved protein [Function unknown]; Region: COG5654 443149005362 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 443149005363 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 443149005364 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443149005365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149005367 dimerization interface [polypeptide binding]; other site 443149005368 putative DNA binding site [nucleotide binding]; other site 443149005369 putative Zn2+ binding site [ion binding]; other site 443149005370 Hemerythrin-like domain; Region: Hr-like; cd12108 443149005371 Fe binding site [ion binding]; other site 443149005372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005373 Ligand Binding Site [chemical binding]; other site 443149005374 potential frameshift: common BLAST hit: gi|375296201|ref|YP_005100468.1| metal cation transporting P-type ATPase ctpF 443149005375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149005376 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 443149005377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005378 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 443149005379 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149005380 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 443149005381 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149005382 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 443149005383 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443149005384 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 443149005385 tetramer interface [polypeptide binding]; other site 443149005386 active site 443149005387 Mg2+/Mn2+ binding site [ion binding]; other site 443149005388 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149005389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149005390 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443149005391 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 443149005392 homotetramer interface [polypeptide binding]; other site 443149005393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443149005394 NAD binding site [chemical binding]; other site 443149005395 homodimer interface [polypeptide binding]; other site 443149005396 active site 443149005397 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005399 S-adenosylmethionine binding site [chemical binding]; other site 443149005400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 443149005401 Predicted kinase [General function prediction only]; Region: COG0645 443149005402 AAA domain; Region: AAA_17; pfam13207 443149005403 Universal stress protein family; Region: Usp; pfam00582 443149005404 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005405 Ligand Binding Site [chemical binding]; other site 443149005406 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443149005407 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443149005408 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 443149005409 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443149005410 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443149005411 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443149005412 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443149005413 Ferredoxin [Energy production and conversion]; Region: COG1146 443149005414 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149005415 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149005416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149005417 Walker A motif; other site 443149005418 ATP binding site [chemical binding]; other site 443149005419 Walker B motif; other site 443149005420 arginine finger; other site 443149005421 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149005422 putative active site [active] 443149005423 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149005424 MarR family; Region: MarR_2; pfam12802 443149005425 Phage envelope protein [General function prediction only]; Region: COG5562 443149005426 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149005427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149005428 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149005429 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005431 active site 443149005432 putative transposase OrfB; Reviewed; Region: PHA02517 443149005433 HTH-like domain; Region: HTH_21; pfam13276 443149005434 Integrase core domain; Region: rve; pfam00665 443149005435 Integrase core domain; Region: rve_3; pfam13683 443149005436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005437 Transposase; Region: HTH_Tnp_1; cl17663 443149005438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443149005439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149005440 non-specific DNA binding site [nucleotide binding]; other site 443149005441 salt bridge; other site 443149005442 sequence-specific DNA binding site [nucleotide binding]; other site 443149005443 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443149005444 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443149005445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443149005446 Predicted helicase [General function prediction only]; Region: COG4889 443149005447 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 443149005448 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 443149005449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005450 ATP binding site [chemical binding]; other site 443149005451 putative Mg++ binding site [ion binding]; other site 443149005452 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 443149005453 ATP-binding site [chemical binding]; other site 443149005454 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149005455 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443149005456 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 443149005457 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005458 Ligand Binding Site [chemical binding]; other site 443149005459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005460 Ligand Binding Site [chemical binding]; other site 443149005461 potential frameshift: common BLAST hit: gi|383307840|ref|YP_005360651.1| histidine kinase response regulator 443149005462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149005463 Histidine kinase; Region: HisKA_3; pfam07730 443149005464 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149005465 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443149005466 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149005467 Ligand Binding Site [chemical binding]; other site 443149005468 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443149005469 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443149005470 putative substrate binding site [chemical binding]; other site 443149005471 putative ATP binding site [chemical binding]; other site 443149005472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149005473 active site 443149005474 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 443149005475 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443149005476 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443149005477 putative dimer interface [polypeptide binding]; other site 443149005478 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149005479 dimer interface [polypeptide binding]; other site 443149005480 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443149005481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149005482 putative DNA binding site [nucleotide binding]; other site 443149005483 dimerization interface [polypeptide binding]; other site 443149005484 putative Zn2+ binding site [ion binding]; other site 443149005485 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 443149005486 putative hydrophobic ligand binding site [chemical binding]; other site 443149005487 CLM binding site; other site 443149005488 L1 loop; other site 443149005489 DNA binding site [nucleotide binding] 443149005490 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149005491 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149005492 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 443149005493 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149005494 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 443149005495 nucleophile elbow; other site 443149005496 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443149005497 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149005498 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149005499 Walker A/P-loop; other site 443149005500 ATP binding site [chemical binding]; other site 443149005501 Q-loop/lid; other site 443149005502 ABC transporter signature motif; other site 443149005503 Walker B; other site 443149005504 D-loop; other site 443149005505 H-loop/switch region; other site 443149005506 TOBE domain; Region: TOBE_2; pfam08402 443149005507 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149005508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005509 dimer interface [polypeptide binding]; other site 443149005510 conserved gate region; other site 443149005511 putative PBP binding loops; other site 443149005512 ABC-ATPase subunit interface; other site 443149005513 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443149005514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149005515 dimer interface [polypeptide binding]; other site 443149005516 conserved gate region; other site 443149005517 putative PBP binding loops; other site 443149005518 ABC-ATPase subunit interface; other site 443149005519 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443149005520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149005521 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 443149005522 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443149005523 Isochorismatase family; Region: Isochorismatase; pfam00857 443149005524 catalytic triad [active] 443149005525 metal binding site [ion binding]; metal-binding site 443149005526 conserved cis-peptide bond; other site 443149005527 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443149005528 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443149005529 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149005530 substrate binding pocket [chemical binding]; other site 443149005531 catalytic triad [active] 443149005532 hypothetical protein; Provisional; Region: PRK05865 443149005533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005534 NAD(P) binding site [chemical binding]; other site 443149005535 active site 443149005536 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443149005537 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149005538 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149005539 active site 443149005540 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149005541 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149005542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005543 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149005544 Enoylreductase; Region: PKS_ER; smart00829 443149005545 NAD(P) binding site [chemical binding]; other site 443149005546 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149005547 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149005548 putative NADP binding site [chemical binding]; other site 443149005549 active site 443149005550 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149005551 potential frameshift: common BLAST hit: gi|378771782|ref|YP_005171515.1| polyprenol-monophosphomannose synthase 443149005552 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 443149005553 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443149005554 Ligand binding site; other site 443149005555 Putative Catalytic site; other site 443149005556 DXD motif; other site 443149005557 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 443149005558 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443149005559 putative active site [active] 443149005560 catalytic triad [active] 443149005561 putative dimer interface [polypeptide binding]; other site 443149005562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149005563 active site 443149005564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149005565 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 443149005566 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443149005567 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443149005568 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 443149005569 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 443149005570 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443149005571 intersubunit interface [polypeptide binding]; other site 443149005572 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 443149005573 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 443149005574 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443149005575 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443149005576 precorrin-3B synthase; Region: CobG; TIGR02435 443149005577 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149005578 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 443149005579 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443149005580 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 443149005581 active site 443149005582 SAM binding site [chemical binding]; other site 443149005583 homodimer interface [polypeptide binding]; other site 443149005584 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 443149005585 active site 443149005586 SAM binding site [chemical binding]; other site 443149005587 homodimer interface [polypeptide binding]; other site 443149005588 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443149005589 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443149005590 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 443149005591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149005592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149005593 DNA binding residues [nucleotide binding] 443149005594 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 443149005595 precorrin-6x reductase; Region: precor6x_red; TIGR00715 443149005596 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 443149005597 active site 443149005598 SAM binding site [chemical binding]; other site 443149005599 homodimer interface [polypeptide binding]; other site 443149005600 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 443149005601 active site 443149005602 putative homodimer interface [polypeptide binding]; other site 443149005603 SAM binding site [chemical binding]; other site 443149005604 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 443149005605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149005606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149005607 NAD(P) binding site [chemical binding]; other site 443149005608 active site 443149005609 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149005610 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 443149005611 putative active site [active] 443149005612 catalytic site [active] 443149005613 putative metal binding site [ion binding]; other site 443149005614 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 443149005615 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 443149005616 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149005617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149005618 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149005619 active site 443149005620 ATP binding site [chemical binding]; other site 443149005621 substrate binding site [chemical binding]; other site 443149005622 activation loop (A-loop); other site 443149005623 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149005624 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443149005625 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443149005626 active site 443149005627 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 443149005628 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443149005629 active site 443149005630 metal binding site 1 [ion binding]; metal-binding site 443149005631 putative 5' ssDNA interaction site; other site 443149005632 metal binding site 3; metal-binding site 443149005633 metal binding site 2 [ion binding]; metal-binding site 443149005634 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443149005635 putative DNA binding site [nucleotide binding]; other site 443149005636 putative metal binding site [ion binding]; other site 443149005637 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149005638 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 443149005639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005640 ATP binding site [chemical binding]; other site 443149005641 putative Mg++ binding site [ion binding]; other site 443149005642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149005643 nucleotide binding region [chemical binding]; other site 443149005644 ATP-binding site [chemical binding]; other site 443149005645 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443149005646 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 443149005647 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 443149005648 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 443149005649 Predicted transcriptional regulator [Transcription]; Region: COG2378 443149005650 WYL domain; Region: WYL; pfam13280 443149005651 Predicted transcriptional regulator [Transcription]; Region: COG2378 443149005652 WYL domain; Region: WYL; pfam13280 443149005653 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 443149005654 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149005655 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149005656 active site 443149005657 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 443149005658 SNF2 Helicase protein; Region: DUF3670; pfam12419 443149005659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149005660 ATP binding site [chemical binding]; other site 443149005661 putative Mg++ binding site [ion binding]; other site 443149005662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149005663 nucleotide binding region [chemical binding]; other site 443149005664 ATP-binding site [chemical binding]; other site 443149005665 Uncharacterized conserved protein [Function unknown]; Region: COG4279 443149005666 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149005667 putative active site [active] 443149005668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005669 Transposase; Region: HTH_Tnp_1; cl17663 443149005670 putative transposase OrfB; Reviewed; Region: PHA02517 443149005671 HTH-like domain; Region: HTH_21; pfam13276 443149005672 Integrase core domain; Region: rve; pfam00665 443149005673 Integrase core domain; Region: rve_3; pfam13683 443149005674 putative transposase OrfB; Reviewed; Region: PHA02517 443149005675 HTH-like domain; Region: HTH_21; pfam13276 443149005676 Integrase core domain; Region: rve; pfam00665 443149005677 Integrase core domain; Region: rve_3; pfam13683 443149005678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149005679 Transposase; Region: HTH_Tnp_1; cl17663 443149005680 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005681 PPE family; Region: PPE; pfam00823 443149005682 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 443149005683 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443149005684 active site 443149005685 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 443149005686 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443149005687 active site 443149005688 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 443149005689 proteasome ATPase; Region: pup_AAA; TIGR03689 443149005690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149005691 Walker A motif; other site 443149005692 ATP binding site [chemical binding]; other site 443149005693 Walker B motif; other site 443149005694 arginine finger; other site 443149005695 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443149005696 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443149005697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149005698 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149005699 Predicted membrane protein [Function unknown]; Region: COG3918 443149005700 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443149005701 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443149005702 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443149005703 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149005704 PPE family; Region: PPE; pfam00823 443149005705 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 443149005706 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 443149005707 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 443149005708 substrate binding pocket [chemical binding]; other site 443149005709 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 443149005710 B12 binding site [chemical binding]; other site 443149005711 cobalt ligand [ion binding]; other site 443149005712 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 443149005713 PAC2 family; Region: PAC2; cl00847 443149005714 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443149005715 short chain dehydrogenase; Provisional; Region: PRK05872 443149005716 classical (c) SDRs; Region: SDR_c; cd05233 443149005717 NAD(P) binding site [chemical binding]; other site 443149005718 active site 443149005719 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443149005720 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443149005721 active site 443149005722 HIGH motif; other site 443149005723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149005724 active site 443149005725 KMSKS motif; other site 443149005726 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 443149005727 putative tRNA binding surface [nucleotide binding]; other site 443149005728 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 443149005729 active site 443149005730 conserved hypothetical protein; Region: TIGR03843 443149005731 conserved hypothetical protein; Region: TIGR03847 443149005732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149005733 catalytic core [active] 443149005734 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 443149005735 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 443149005736 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443149005737 quinone interaction residues [chemical binding]; other site 443149005738 active site 443149005739 catalytic residues [active] 443149005740 FMN binding site [chemical binding]; other site 443149005741 substrate binding site [chemical binding]; other site 443149005742 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443149005743 substrate binding site [chemical binding]; other site 443149005744 hypothetical protein; Provisional; Region: PRK07906 443149005745 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443149005746 putative metal binding site [ion binding]; other site 443149005747 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 443149005748 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149005749 active site 443149005750 DivIVA domain; Region: DivI1A_domain; TIGR03544 443149005751 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443149005752 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 443149005753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 443149005754 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 443149005755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149005756 catalytic residue [active] 443149005757 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443149005758 uncharacterized protein, YfiH family; Region: TIGR00726 443149005759 cell division protein FtsZ; Validated; Region: PRK09330 443149005760 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443149005761 nucleotide binding site [chemical binding]; other site 443149005762 SulA interaction site; other site 443149005763 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 443149005764 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443149005765 Cell division protein FtsQ; Region: FtsQ; pfam03799 443149005766 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443149005767 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443149005768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149005769 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149005770 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443149005771 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 443149005772 active site 443149005773 homodimer interface [polypeptide binding]; other site 443149005774 cell division protein FtsW; Region: ftsW; TIGR02614 443149005775 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 443149005776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149005777 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149005778 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443149005779 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443149005780 Mg++ binding site [ion binding]; other site 443149005781 putative catalytic motif [active] 443149005782 putative substrate binding site [chemical binding]; other site 443149005783 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149005784 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149005785 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443149005786 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443149005787 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443149005788 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149005789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149005790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149005791 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149005792 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149005793 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149005794 PE family; Region: PE; pfam00934 443149005795 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149005796 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443149005797 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149005798 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 443149005799 MraW methylase family; Region: Methyltransf_5; pfam01795 443149005800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 443149005801 MraZ protein; Region: MraZ; pfam02381 443149005802 MraZ protein; Region: MraZ; pfam02381 443149005803 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443149005804 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 443149005805 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149005806 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149005807 substrate binding pocket [chemical binding]; other site 443149005808 chain length determination region; other site 443149005809 substrate-Mg2+ binding site; other site 443149005810 catalytic residues [active] 443149005811 aspartate-rich region 1; other site 443149005812 active site lid residues [active] 443149005813 aspartate-rich region 2; other site 443149005814 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443149005815 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149005816 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149005817 active site 443149005818 ATP binding site [chemical binding]; other site 443149005819 substrate binding site [chemical binding]; other site 443149005820 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443149005821 substrate binding site [chemical binding]; other site 443149005822 activation loop (A-loop); other site 443149005823 activation loop (A-loop); other site 443149005824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149005825 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149005826 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 443149005827 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443149005828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149005829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149005830 putative acyl-acceptor binding pocket; other site 443149005831 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149005832 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149005833 DTAP/Switch II; other site 443149005834 Switch I; other site 443149005835 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443149005836 putative hydrophobic ligand binding site [chemical binding]; other site 443149005837 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149005838 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443149005839 acyl-activating enzyme (AAE) consensus motif; other site 443149005840 putative AMP binding site [chemical binding]; other site 443149005841 putative active site [active] 443149005842 putative CoA binding site [chemical binding]; other site 443149005843 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149005844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149005845 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 443149005846 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443149005847 NlpC/P60 family; Region: NLPC_P60; pfam00877 443149005848 hypothetical protein; Validated; Region: PRK07883 443149005849 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443149005850 active site 443149005851 catalytic site [active] 443149005852 substrate binding site [chemical binding]; other site 443149005853 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443149005854 GIY-YIG motif/motif A; other site 443149005855 active site 443149005856 catalytic site [active] 443149005857 putative DNA binding site [nucleotide binding]; other site 443149005858 metal binding site [ion binding]; metal-binding site 443149005859 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443149005860 Subunit I/III interface [polypeptide binding]; other site 443149005861 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443149005862 Cytochrome c; Region: Cytochrom_C; pfam00034 443149005863 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443149005864 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443149005865 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443149005866 iron-sulfur cluster [ion binding]; other site 443149005867 [2Fe-2S] cluster binding site [ion binding]; other site 443149005868 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443149005869 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443149005870 heme bH binding site [chemical binding]; other site 443149005871 intrachain domain interface; other site 443149005872 heme bL binding site [chemical binding]; other site 443149005873 interchain domain interface [polypeptide binding]; other site 443149005874 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 443149005875 Qo binding site; other site 443149005876 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 443149005877 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443149005878 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443149005879 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 443149005880 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443149005881 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443149005882 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443149005883 dimer interface [polypeptide binding]; other site 443149005884 active site 443149005885 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443149005886 Ligand Binding Site [chemical binding]; other site 443149005887 Molecular Tunnel; other site 443149005888 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 443149005889 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443149005890 substrate binding site [chemical binding]; other site 443149005891 ATP binding site [chemical binding]; other site 443149005892 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 443149005893 Glycerate kinase family; Region: Gly_kinase; pfam02595 443149005894 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443149005895 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443149005896 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443149005897 putative dimer interface [polypeptide binding]; other site 443149005898 active site pocket [active] 443149005899 putative cataytic base [active] 443149005900 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 443149005901 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443149005902 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443149005903 homodimer interface [polypeptide binding]; other site 443149005904 substrate-cofactor binding pocket; other site 443149005905 catalytic residue [active] 443149005906 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443149005907 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443149005908 cyclase homology domain; Region: CHD; cd07302 443149005909 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149005910 nucleotidyl binding site; other site 443149005911 metal binding site [ion binding]; metal-binding site 443149005912 dimer interface [polypeptide binding]; other site 443149005913 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443149005914 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443149005915 interface (dimer of trimers) [polypeptide binding]; other site 443149005916 Substrate-binding/catalytic site; other site 443149005917 Zn-binding sites [ion binding]; other site 443149005918 short chain dehydrogenase; Validated; Region: PRK05855 443149005919 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149005920 classical (c) SDRs; Region: SDR_c; cd05233 443149005921 NAD(P) binding site [chemical binding]; other site 443149005922 active site 443149005923 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 443149005924 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149005925 E3 interaction surface; other site 443149005926 lipoyl attachment site [posttranslational modification]; other site 443149005927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149005928 E3 interaction surface; other site 443149005929 lipoyl attachment site [posttranslational modification]; other site 443149005930 e3 binding domain; Region: E3_binding; pfam02817 443149005931 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149005932 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 443149005933 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 443149005934 putative NAD(P) binding site [chemical binding]; other site 443149005935 putative active site [active] 443149005936 lipoate-protein ligase B; Provisional; Region: PRK14345 443149005937 lipoyl synthase; Provisional; Region: PRK05481 443149005938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149005939 FeS/SAM binding site; other site 443149005940 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443149005941 RDD family; Region: RDD; pfam06271 443149005942 glutamine synthetase, type I; Region: GlnA; TIGR00653 443149005943 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149005944 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149005945 potential frameshift: common BLAST hit: gi|378771952|ref|YP_005171685.1| glutamate-ammonia-ligase adenylyltransferase 443149005946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443149005947 metal binding triad; other site 443149005948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149005949 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443149005950 metal binding triad; other site 443149005951 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149005952 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149005953 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149005954 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149005955 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149005956 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149005957 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443149005958 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149005959 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443149005960 oligomerization interface [polypeptide binding]; other site 443149005961 active site 443149005962 metal binding site [ion binding]; metal-binding site 443149005963 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443149005964 putative active site; other site 443149005965 putative metal binding residues [ion binding]; other site 443149005966 signature motif; other site 443149005967 putative triphosphate binding site [ion binding]; other site 443149005968 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443149005969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 443149005970 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443149005971 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 443149005972 RNA/DNA hybrid binding site [nucleotide binding]; other site 443149005973 active site 443149005974 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149005975 catalytic core [active] 443149005976 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443149005977 Putative zinc ribbon domain; Region: DUF164; pfam02591 443149005978 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443149005979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 443149005980 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443149005981 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443149005982 hypothetical protein; Provisional; Region: PRK07908 443149005983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149005984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149005985 homodimer interface [polypeptide binding]; other site 443149005986 catalytic residue [active] 443149005987 phosphoglycolate phosphatase; Provisional; Region: PRK13222 443149005988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149005989 active site 443149005990 motif I; other site 443149005991 motif II; other site 443149005992 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443149005993 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443149005994 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443149005995 potential frameshift: common BLAST hit: gi|253798697|ref|YP_003031698.1| cobalamin biosynthesis protein 443149005996 CobD/Cbib protein; Region: CobD_Cbib; cl00561 443149005997 CobD/Cbib protein; Region: CobD_Cbib; cl00561 443149005998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 443149005999 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149006000 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443149006001 dimer interface [polypeptide binding]; other site 443149006002 catalytic triad [active] 443149006003 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 443149006004 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443149006005 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443149006006 dimer interface [polypeptide binding]; other site 443149006007 TPP-binding site [chemical binding]; other site 443149006008 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149006009 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443149006010 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149006011 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149006012 acyl carrier protein; Provisional; Region: acpP; PRK00982 443149006013 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443149006014 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443149006015 dimer interface [polypeptide binding]; other site 443149006016 active site 443149006017 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443149006018 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443149006019 dimer interface [polypeptide binding]; other site 443149006020 active site 443149006021 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149006022 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149006023 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149006024 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149006025 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443149006026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149006027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149006028 potential frameshift: common BLAST hit: gi|383308050|ref|YP_005360861.1| putative flavoprotein 443149006029 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149006030 FAD binding domain; Region: FAD_binding_4; pfam01565 443149006031 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 443149006032 diacylglycerol kinase; Reviewed; Region: PRK11914 443149006033 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443149006034 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443149006035 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149006036 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149006037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149006038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149006039 S-adenosylmethionine binding site [chemical binding]; other site 443149006040 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443149006041 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149006042 NAD binding site [chemical binding]; other site 443149006043 catalytic Zn binding site [ion binding]; other site 443149006044 substrate binding site [chemical binding]; other site 443149006045 structural Zn binding site [ion binding]; other site 443149006046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149006047 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 443149006048 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443149006049 putative active site [active] 443149006050 catalytic triad [active] 443149006051 putative dimer interface [polypeptide binding]; other site 443149006052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149006053 active site 443149006054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149006055 nucleotide binding site [chemical binding]; other site 443149006056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006058 Cytochrome P450; Region: p450; cl12078 443149006059 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 443149006060 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006061 Cytochrome P450; Region: p450; cl12078 443149006062 Septum formation; Region: Septum_form; pfam13845 443149006063 Predicted membrane protein [Function unknown]; Region: COG2149 443149006064 Domain of unknown function (DUF202); Region: DUF202; pfam02656 443149006065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149006066 Cytochrome P450; Region: p450; cl12078 443149006067 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 443149006068 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149006069 putative active site [active] 443149006070 catalytic site [active] 443149006071 putative metal binding site [ion binding]; other site 443149006072 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443149006073 FAD binding domain; Region: FAD_binding_4; pfam01565 443149006074 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149006075 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443149006076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443149006077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443149006078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443149006079 dimerization interface [polypeptide binding]; other site 443149006080 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149006081 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149006082 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006083 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149006084 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149006085 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149006086 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443149006087 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 443149006088 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 443149006089 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149006090 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149006091 active site residue [active] 443149006092 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149006093 active site residue [active] 443149006094 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 443149006095 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443149006096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149006097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006098 homodimer interface [polypeptide binding]; other site 443149006099 catalytic residue [active] 443149006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 443149006101 haloalkane dehalogenase; Provisional; Region: PRK00870 443149006102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443149006103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443149006104 active site 443149006105 catalytic tetrad [active] 443149006106 heat shock protein 90; Provisional; Region: PRK05218 443149006107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149006108 ATP binding site [chemical binding]; other site 443149006109 Mg2+ binding site [ion binding]; other site 443149006110 G-X-G motif; other site 443149006111 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149006112 Cutinase; Region: Cutinase; pfam01083 443149006113 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149006114 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 443149006115 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443149006116 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 443149006118 Uncharacterized conserved protein [Function unknown]; Region: COG2442 443149006119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149006120 DNA binding site [nucleotide binding] 443149006121 active site 443149006122 Int/Topo IB signature motif; other site 443149006123 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 443149006124 DNA binding residues [nucleotide binding] 443149006125 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 443149006126 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443149006127 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443149006128 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 443149006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006130 putative PBP binding loops; other site 443149006131 ABC-ATPase subunit interface; other site 443149006132 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006134 dimer interface [polypeptide binding]; other site 443149006135 conserved gate region; other site 443149006136 putative PBP binding loops; other site 443149006137 ABC-ATPase subunit interface; other site 443149006138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443149006139 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443149006140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149006141 Ligand Binding Site [chemical binding]; other site 443149006142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149006143 Ligand Binding Site [chemical binding]; other site 443149006144 amino acid transporter; Region: 2A0306; TIGR00909 443149006145 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443149006146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149006147 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 443149006148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149006149 catalytic residue [active] 443149006150 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149006151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149006152 Amidinotransferase; Region: Amidinotransf; pfam02274 443149006153 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 443149006154 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149006155 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443149006156 putative DNA binding site [nucleotide binding]; other site 443149006157 putative Zn2+ binding site [ion binding]; other site 443149006158 AsnC family; Region: AsnC_trans_reg; pfam01037 443149006159 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 443149006160 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443149006161 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 443149006162 Walker A/P-loop; other site 443149006163 ATP binding site [chemical binding]; other site 443149006164 Q-loop/lid; other site 443149006165 ABC transporter signature motif; other site 443149006166 Walker B; other site 443149006167 D-loop; other site 443149006168 H-loop/switch region; other site 443149006169 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443149006170 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443149006171 Walker A/P-loop; other site 443149006172 ATP binding site [chemical binding]; other site 443149006173 Q-loop/lid; other site 443149006174 ABC transporter signature motif; other site 443149006175 Walker B; other site 443149006176 D-loop; other site 443149006177 H-loop/switch region; other site 443149006178 MarR family; Region: MarR; pfam01047 443149006179 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149006180 PE family; Region: PE; pfam00934 443149006181 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 443149006182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006183 putative substrate translocation pore; other site 443149006184 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 443149006185 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443149006186 malate dehydrogenase; Provisional; Region: PRK13529 443149006187 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443149006188 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 443149006189 NAD(P) binding site [chemical binding]; other site 443149006190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006192 putative substrate translocation pore; other site 443149006193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006194 putative substrate translocation pore; other site 443149006195 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149006196 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443149006197 dimer interface [polypeptide binding]; other site 443149006198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006199 catalytic residue [active] 443149006200 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 443149006201 serine O-acetyltransferase; Region: cysE; TIGR01172 443149006202 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443149006203 trimer interface [polypeptide binding]; other site 443149006204 active site 443149006205 substrate binding site [chemical binding]; other site 443149006206 CoA binding site [chemical binding]; other site 443149006207 hypothetical protein; Provisional; Region: PRK14851 443149006208 hypothetical protein; Validated; Region: PRK08223 443149006209 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 443149006210 ATP binding site [chemical binding]; other site 443149006211 substrate interface [chemical binding]; other site 443149006212 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149006213 PE family; Region: PE; pfam00934 443149006214 DNA primase, catalytic core; Region: dnaG; TIGR01391 443149006215 CHC2 zinc finger; Region: zf-CHC2; cl17510 443149006216 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443149006217 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443149006218 active site 443149006219 metal binding site [ion binding]; metal-binding site 443149006220 interdomain interaction site; other site 443149006221 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443149006222 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 443149006223 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443149006224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149006225 Zn2+ binding site [ion binding]; other site 443149006226 Mg2+ binding site [ion binding]; other site 443149006227 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443149006228 Repair protein; Region: Repair_PSII; pfam04536 443149006229 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006230 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006231 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006232 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006233 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443149006234 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149006235 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006236 PPE family; Region: PPE; pfam00823 443149006237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149006238 Transposase; Region: HTH_Tnp_1; cl17663 443149006239 putative transposase OrfB; Reviewed; Region: PHA02517 443149006240 HTH-like domain; Region: HTH_21; pfam13276 443149006241 Integrase core domain; Region: rve; pfam00665 443149006242 Integrase core domain; Region: rve_3; pfam13683 443149006243 PPE family; Region: PPE; pfam00823 443149006244 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006245 PPE family; Region: PPE; pfam00823 443149006246 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443149006247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149006248 motif 1; other site 443149006249 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 443149006250 active site 443149006251 motif 2; other site 443149006252 motif 3; other site 443149006253 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443149006254 anticodon binding site; other site 443149006255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149006256 dimerization interface [polypeptide binding]; other site 443149006257 putative DNA binding site [nucleotide binding]; other site 443149006258 putative Zn2+ binding site [ion binding]; other site 443149006259 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443149006260 metal binding site 2 [ion binding]; metal-binding site 443149006261 putative DNA binding helix; other site 443149006262 metal binding site 1 [ion binding]; metal-binding site 443149006263 dimer interface [polypeptide binding]; other site 443149006264 structural Zn2+ binding site [ion binding]; other site 443149006265 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 443149006266 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443149006267 catalytic residue [active] 443149006268 putative FPP diphosphate binding site; other site 443149006269 putative FPP binding hydrophobic cleft; other site 443149006270 dimer interface [polypeptide binding]; other site 443149006271 putative IPP diphosphate binding site; other site 443149006272 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443149006273 Recombination protein O N terminal; Region: RecO_N; pfam11967 443149006274 Recombination protein O C terminal; Region: RecO_C; pfam02565 443149006275 amidase; Provisional; Region: PRK06061 443149006276 Amidase; Region: Amidase; pfam01425 443149006277 GTPase Era; Reviewed; Region: era; PRK00089 443149006278 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443149006279 G1 box; other site 443149006280 GTP/Mg2+ binding site [chemical binding]; other site 443149006281 Switch I region; other site 443149006282 G2 box; other site 443149006283 Switch II region; other site 443149006284 G3 box; other site 443149006285 G4 box; other site 443149006286 G5 box; other site 443149006287 KH domain; Region: KH_2; pfam07650 443149006288 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443149006289 Domain of unknown function DUF21; Region: DUF21; pfam01595 443149006290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443149006291 Transporter associated domain; Region: CorC_HlyC; smart01091 443149006292 metal-binding heat shock protein; Provisional; Region: PRK00016 443149006293 K homology RNA-binding domain; Region: KH; smart00322 443149006294 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443149006295 PhoH-like protein; Region: PhoH; pfam02562 443149006296 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443149006297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 443149006298 RNA methyltransferase, RsmE family; Region: TIGR00046 443149006299 chaperone protein DnaJ; Provisional; Region: PRK14278 443149006300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443149006301 HSP70 interaction site [polypeptide binding]; other site 443149006302 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443149006303 Zn binding sites [ion binding]; other site 443149006304 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443149006305 dimer interface [polypeptide binding]; other site 443149006306 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443149006307 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 443149006308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149006309 potential frameshift: common BLAST hit: gi|375295807|ref|YP_005100074.1| peptide synthetase mbtF 443149006310 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149006311 AMP binding site [chemical binding]; other site 443149006312 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443149006313 Condensation domain; Region: Condensation; pfam00668 443149006314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149006316 acyl-activating enzyme (AAE) consensus motif; other site 443149006317 Condensation domain; Region: Condensation; pfam00668 443149006318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006319 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149006320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 443149006321 acyl-activating enzyme (AAE) consensus motif; other site 443149006322 AMP binding site [chemical binding]; other site 443149006323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006324 Condensation domain; Region: Condensation; pfam00668 443149006325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443149006327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149006328 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006329 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149006330 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149006331 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149006332 NADP binding site [chemical binding]; other site 443149006333 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149006334 active site 443149006335 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149006336 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149006337 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149006338 active site 443149006339 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 443149006340 Condensation domain; Region: Condensation; pfam00668 443149006341 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443149006342 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443149006343 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443149006344 acyl-activating enzyme (AAE) consensus motif; other site 443149006345 AMP binding site [chemical binding]; other site 443149006346 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149006347 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443149006348 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 443149006349 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 443149006350 acyl-activating enzyme (AAE) consensus motif; other site 443149006351 active site 443149006352 AMP binding site [chemical binding]; other site 443149006353 substrate binding site [chemical binding]; other site 443149006354 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149006355 salicylate synthase MbtI; Reviewed; Region: PRK07912 443149006356 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149006357 Predicted permease [General function prediction only]; Region: COG3329 443149006358 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443149006359 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 443149006360 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 443149006361 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149006362 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443149006363 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 443149006364 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443149006365 Active Sites [active] 443149006366 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443149006367 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443149006368 putative active site [active] 443149006369 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443149006370 putative active site [active] 443149006371 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 443149006372 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443149006373 Predicted membrane protein [Function unknown]; Region: COG1297 443149006374 putative oligopeptide transporter, OPT family; Region: TIGR00733 443149006375 PE family; Region: PE; pfam00934 443149006376 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 443149006377 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 443149006378 Walker A/P-loop; other site 443149006379 ATP binding site [chemical binding]; other site 443149006380 Q-loop/lid; other site 443149006381 ABC transporter signature motif; other site 443149006382 Walker B; other site 443149006383 D-loop; other site 443149006384 H-loop/switch region; other site 443149006385 sulfate transport protein; Provisional; Region: cysT; CHL00187 443149006386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006387 dimer interface [polypeptide binding]; other site 443149006388 conserved gate region; other site 443149006389 putative PBP binding loops; other site 443149006390 ABC-ATPase subunit interface; other site 443149006391 sulfate transport protein; Provisional; Region: cysT; CHL00187 443149006392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149006393 dimer interface [polypeptide binding]; other site 443149006394 conserved gate region; other site 443149006395 putative PBP binding loops; other site 443149006396 ABC-ATPase subunit interface; other site 443149006397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149006398 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443149006399 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443149006400 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443149006401 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149006402 GTP-binding protein LepA; Provisional; Region: PRK05433 443149006403 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443149006404 G1 box; other site 443149006405 putative GEF interaction site [polypeptide binding]; other site 443149006406 GTP/Mg2+ binding site [chemical binding]; other site 443149006407 Switch I region; other site 443149006408 G2 box; other site 443149006409 G3 box; other site 443149006410 Switch II region; other site 443149006411 G4 box; other site 443149006412 G5 box; other site 443149006413 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443149006414 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443149006415 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443149006416 PemK-like protein; Region: PemK; pfam02452 443149006417 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 443149006418 FOG: CBS domain [General function prediction only]; Region: COG0517 443149006419 ribonuclease Z; Reviewed; Region: PRK00055 443149006420 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149006421 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149006422 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149006423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443149006424 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443149006425 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443149006426 hypothetical protein; Reviewed; Region: PRK07914 443149006427 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443149006428 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443149006429 Competence protein; Region: Competence; pfam03772 443149006430 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443149006431 Helix-hairpin-helix motif; Region: HHH; pfam00633 443149006432 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 443149006433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149006434 Coenzyme A binding pocket [chemical binding]; other site 443149006435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 443149006436 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 443149006437 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443149006438 active site 443149006439 catalytic triad [active] 443149006440 oxyanion hole [active] 443149006441 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149006442 catalytic core [active] 443149006443 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 443149006444 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443149006445 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443149006446 active site 443149006447 (T/H)XGH motif; other site 443149006448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149006449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149006450 S-adenosylmethionine binding site [chemical binding]; other site 443149006451 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149006452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149006453 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149006454 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443149006455 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443149006456 metal ion-dependent adhesion site (MIDAS); other site 443149006457 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443149006458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006459 Walker A motif; other site 443149006460 ATP binding site [chemical binding]; other site 443149006461 Walker B motif; other site 443149006462 arginine finger; other site 443149006463 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443149006464 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443149006465 putative catalytic cysteine [active] 443149006466 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443149006467 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 443149006468 dimer interface [polypeptide binding]; other site 443149006469 decamer (pentamer of dimers) interface [polypeptide binding]; other site 443149006470 catalytic triad [active] 443149006471 peroxidatic and resolving cysteines [active] 443149006472 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 443149006473 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 443149006474 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006475 PPE family; Region: PPE; pfam00823 443149006476 potential frameshift: common BLAST hit: gi|378772168|ref|YP_005171901.1| putative transmembrane protein 443149006477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149006478 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149006479 ligand binding site [chemical binding]; other site 443149006480 flexible hinge region; other site 443149006481 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443149006482 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443149006483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149006484 dimerization interface [polypeptide binding]; other site 443149006485 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443149006486 cyclase homology domain; Region: CHD; cd07302 443149006487 nucleotidyl binding site; other site 443149006488 metal binding site [ion binding]; metal-binding site 443149006489 dimer interface [polypeptide binding]; other site 443149006490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443149006491 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443149006492 substrate binding site [chemical binding]; other site 443149006493 ATP binding site [chemical binding]; other site 443149006494 NAD synthetase; Reviewed; Region: nadE; PRK02628 443149006495 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 443149006496 multimer interface [polypeptide binding]; other site 443149006497 active site 443149006498 catalytic triad [active] 443149006499 protein interface 1 [polypeptide binding]; other site 443149006500 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443149006501 homodimer interface [polypeptide binding]; other site 443149006502 NAD binding pocket [chemical binding]; other site 443149006503 ATP binding pocket [chemical binding]; other site 443149006504 Mg binding site [ion binding]; other site 443149006505 active-site loop [active] 443149006506 glutamate 5-kinase; Region: proB; TIGR01027 443149006507 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443149006508 nucleotide binding site [chemical binding]; other site 443149006509 homotetrameric interface [polypeptide binding]; other site 443149006510 putative phosphate binding site [ion binding]; other site 443149006511 putative allosteric binding site; other site 443149006512 PUA domain; Region: PUA; pfam01472 443149006513 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443149006514 GTP1/OBG; Region: GTP1_OBG; pfam01018 443149006515 Obg GTPase; Region: Obg; cd01898 443149006516 G1 box; other site 443149006517 GTP/Mg2+ binding site [chemical binding]; other site 443149006518 Switch I region; other site 443149006519 G2 box; other site 443149006520 G3 box; other site 443149006521 Switch II region; other site 443149006522 G4 box; other site 443149006523 G5 box; other site 443149006524 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 443149006525 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443149006526 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443149006527 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443149006528 homodimer interface [polypeptide binding]; other site 443149006529 oligonucleotide binding site [chemical binding]; other site 443149006530 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443149006531 active site 443149006532 multimer interface [polypeptide binding]; other site 443149006533 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443149006534 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443149006535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443149006536 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443149006537 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149006538 active site 443149006539 HIGH motif; other site 443149006540 nucleotide binding site [chemical binding]; other site 443149006541 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443149006542 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443149006543 active site 443149006544 KMSKS motif; other site 443149006545 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443149006546 tRNA binding surface [nucleotide binding]; other site 443149006547 anticodon binding site; other site 443149006548 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443149006549 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443149006550 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443149006551 NAD(P) binding pocket [chemical binding]; other site 443149006552 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443149006553 GTP binding site; other site 443149006554 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443149006555 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443149006556 TPP-binding site [chemical binding]; other site 443149006557 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 443149006558 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 443149006559 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443149006560 dimer interface [polypeptide binding]; other site 443149006561 PYR/PP interface [polypeptide binding]; other site 443149006562 TPP binding site [chemical binding]; other site 443149006563 substrate binding site [chemical binding]; other site 443149006564 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443149006565 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443149006566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006567 Walker A motif; other site 443149006568 ATP binding site [chemical binding]; other site 443149006569 Walker B motif; other site 443149006570 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 443149006571 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 443149006572 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443149006573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443149006575 putative substrate translocation pore; other site 443149006576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149006577 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443149006578 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443149006579 oligomer interface [polypeptide binding]; other site 443149006580 active site residues [active] 443149006581 Clp protease; Region: CLP_protease; pfam00574 443149006582 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443149006583 oligomer interface [polypeptide binding]; other site 443149006584 active site residues [active] 443149006585 trigger factor; Provisional; Region: tig; PRK01490 443149006586 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443149006587 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443149006588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149006589 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149006590 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149006591 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443149006592 putative DNA binding site [nucleotide binding]; other site 443149006593 catalytic residue [active] 443149006594 putative H2TH interface [polypeptide binding]; other site 443149006595 putative catalytic residues [active] 443149006596 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149006597 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149006598 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 443149006599 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149006600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443149006601 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443149006602 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443149006603 Zn binding site [ion binding]; other site 443149006604 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443149006605 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149006606 active site 443149006607 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443149006608 apolar tunnel; other site 443149006609 heme binding site [chemical binding]; other site 443149006610 dimerization interface [polypeptide binding]; other site 443149006611 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443149006612 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 443149006613 active site 443149006614 catalytic site [active] 443149006615 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443149006616 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443149006617 active site 443149006618 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 443149006619 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443149006620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006622 ABC transporter; Region: ABC_tran_2; pfam12848 443149006623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443149006624 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443149006625 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443149006626 dimer interface [polypeptide binding]; other site 443149006627 ssDNA binding site [nucleotide binding]; other site 443149006628 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443149006629 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 443149006630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443149006631 putative acyl-acceptor binding pocket; other site 443149006632 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149006633 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 443149006634 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149006635 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149006636 putative acyl-acceptor binding pocket; other site 443149006637 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149006638 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149006639 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149006640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149006641 enoyl-CoA hydratase; Provisional; Region: PRK05870 443149006642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149006643 substrate binding site [chemical binding]; other site 443149006644 oxyanion hole (OAH) forming residues; other site 443149006645 trimer interface [polypeptide binding]; other site 443149006646 PE family; Region: PE; pfam00934 443149006647 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443149006648 cyclase homology domain; Region: CHD; cd07302 443149006649 nucleotidyl binding site; other site 443149006650 metal binding site [ion binding]; metal-binding site 443149006651 dimer interface [polypeptide binding]; other site 443149006652 AAA ATPase domain; Region: AAA_16; pfam13191 443149006653 Predicted ATPase [General function prediction only]; Region: COG3903 443149006654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149006655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149006656 DNA binding residues [nucleotide binding] 443149006657 dimerization interface [polypeptide binding]; other site 443149006658 TIGR00725 family protein; Region: TIGR00725 443149006659 thymidylate synthase; Provisional; Region: thyA; PRK00956 443149006660 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149006661 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 443149006662 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443149006663 E3 interaction surface; other site 443149006664 lipoyl attachment site [posttranslational modification]; other site 443149006665 e3 binding domain; Region: E3_binding; pfam02817 443149006666 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443149006667 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443149006668 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443149006669 alpha subunit interface [polypeptide binding]; other site 443149006670 TPP binding site [chemical binding]; other site 443149006671 heterodimer interface [polypeptide binding]; other site 443149006672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149006673 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443149006674 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443149006675 tetramer interface [polypeptide binding]; other site 443149006676 TPP-binding site [chemical binding]; other site 443149006677 heterodimer interface [polypeptide binding]; other site 443149006678 phosphorylation loop region [posttranslational modification] 443149006679 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443149006680 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443149006681 putative active site [active] 443149006682 putative catalytic site [active] 443149006683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149006684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149006685 active site 443149006686 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149006687 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149006688 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443149006689 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149006690 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149006691 carboxyltransferase (CT) interaction site; other site 443149006692 biotinylation site [posttranslational modification]; other site 443149006693 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149006694 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149006695 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149006696 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 443149006697 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443149006698 AMP-binding domain protein; Validated; Region: PRK08315 443149006699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149006700 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443149006701 acyl-activating enzyme (AAE) consensus motif; other site 443149006702 acyl-activating enzyme (AAE) consensus motif; other site 443149006703 putative AMP binding site [chemical binding]; other site 443149006704 putative active site [active] 443149006705 putative CoA binding site [chemical binding]; other site 443149006706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149006707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149006708 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 443149006709 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149006710 classical (c) SDRs; Region: SDR_c; cd05233 443149006711 NAD(P) binding site [chemical binding]; other site 443149006712 active site 443149006713 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 443149006714 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443149006715 catalytic site [active] 443149006716 putative active site [active] 443149006717 putative substrate binding site [chemical binding]; other site 443149006718 dimer interface [polypeptide binding]; other site 443149006719 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149006720 MULE transposase domain; Region: MULE; pfam10551 443149006721 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 443149006722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149006723 non-specific DNA binding site [nucleotide binding]; other site 443149006724 salt bridge; other site 443149006725 sequence-specific DNA binding site [nucleotide binding]; other site 443149006726 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 443149006727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 443149006728 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 443149006729 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 443149006730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443149006731 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 443149006732 PE family; Region: PE; pfam00934 443149006733 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443149006734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149006735 catalytic triad [active] 443149006736 hypothetical protein; Provisional; Region: PRK07907 443149006737 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 443149006738 active site 443149006739 metal binding site [ion binding]; metal-binding site 443149006740 dimer interface [polypeptide binding]; other site 443149006741 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 443149006742 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149006743 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 443149006744 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149006745 phosphate binding site [ion binding]; other site 443149006746 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 443149006747 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 443149006748 putative active site [active] 443149006749 putative catalytic site [active] 443149006750 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443149006751 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149006752 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 443149006753 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 443149006754 putative NAD(P) binding site [chemical binding]; other site 443149006755 active site 443149006756 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 443149006757 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443149006758 active site 443149006759 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 443149006760 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149006761 putative active site [active] 443149006762 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 443149006763 Mrr N-terminal domain; Region: Mrr_N; pfam14338 443149006764 Restriction endonuclease; Region: Mrr_cat; pfam04471 443149006765 ERCC4 domain; Region: ERCC4; pfam02732 443149006766 Lsr2; Region: Lsr2; pfam11774 443149006767 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149006768 putative active site [active] 443149006769 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 443149006770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149006771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149006772 catalytic residue [active] 443149006773 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 443149006774 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 443149006775 elongation factor P; Validated; Region: PRK00529 443149006776 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443149006777 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443149006778 RNA binding site [nucleotide binding]; other site 443149006779 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443149006780 RNA binding site [nucleotide binding]; other site 443149006781 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443149006782 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443149006783 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443149006784 active site 443149006785 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443149006786 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443149006787 trimer interface [polypeptide binding]; other site 443149006788 active site 443149006789 dimer interface [polypeptide binding]; other site 443149006790 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443149006791 active site 443149006792 dimer interface [polypeptide binding]; other site 443149006793 metal binding site [ion binding]; metal-binding site 443149006794 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443149006795 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443149006796 Tetramer interface [polypeptide binding]; other site 443149006797 active site 443149006798 FMN-binding site [chemical binding]; other site 443149006799 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149006800 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149006801 putative active site [active] 443149006802 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 443149006803 oligomeric interface; other site 443149006804 putative active site [active] 443149006805 homodimer interface [polypeptide binding]; other site 443149006806 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 443149006807 putative active site [active] 443149006808 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 443149006809 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 443149006810 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 443149006811 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443149006812 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443149006813 NAD(P) binding site [chemical binding]; other site 443149006814 shikimate binding site; other site 443149006815 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 443149006816 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443149006817 dimerization interface [polypeptide binding]; other site 443149006818 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 443149006819 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443149006820 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443149006821 motif 1; other site 443149006822 active site 443149006823 motif 2; other site 443149006824 motif 3; other site 443149006825 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443149006826 DHHA1 domain; Region: DHHA1; pfam02272 443149006827 Uncharacterized conserved protein [Function unknown]; Region: COG0432 443149006828 recombination factor protein RarA; Reviewed; Region: PRK13342 443149006829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006830 Walker A motif; other site 443149006831 ATP binding site [chemical binding]; other site 443149006832 Walker B motif; other site 443149006833 arginine finger; other site 443149006834 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443149006835 Predicted integral membrane protein [Function unknown]; Region: COG5473 443149006836 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 443149006837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443149006838 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443149006839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443149006840 Walker A/P-loop; other site 443149006841 ATP binding site [chemical binding]; other site 443149006842 Q-loop/lid; other site 443149006843 ABC transporter signature motif; other site 443149006844 Walker B; other site 443149006845 D-loop; other site 443149006846 H-loop/switch region; other site 443149006847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149006848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149006849 ligand binding site [chemical binding]; other site 443149006850 flexible hinge region; other site 443149006851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149006852 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149006853 ligand binding site [chemical binding]; other site 443149006854 flexible hinge region; other site 443149006855 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149006856 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 443149006857 active site 443149006858 nucleophile elbow; other site 443149006859 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149006860 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149006861 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443149006862 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 443149006863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 443149006864 potential frameshift: common BLAST hit: gi|375295617|ref|YP_005099884.1| conserved alanine and leucine rich protein 443149006865 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 443149006866 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 443149006867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443149006868 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443149006869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 443149006870 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 443149006871 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443149006872 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443149006873 Transglutaminase/protease-like homologues; Region: TGc; smart00460 443149006874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 443149006875 Predicted membrane protein [Function unknown]; Region: COG4129 443149006876 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443149006877 potential frameshift: common BLAST hit: gi|375295612|ref|YP_005099879.1| aspartyl-tRNA synthetase aspS 443149006878 GAD domain; Region: GAD; pfam02938 443149006879 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149006880 active site 443149006881 motif 3; other site 443149006882 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443149006883 dimer interface [polypeptide binding]; other site 443149006884 anticodon binding site; other site 443149006885 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 443149006886 homodimer interface [polypeptide binding]; other site 443149006887 motif 1; other site 443149006888 active site 443149006889 motif 2; other site 443149006890 GAD domain; Region: GAD; pfam02938 443149006891 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443149006892 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443149006893 putative hydrophobic ligand binding site [chemical binding]; other site 443149006894 protein interface [polypeptide binding]; other site 443149006895 gate; other site 443149006896 Predicted metalloprotease [General function prediction only]; Region: COG2321 443149006897 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443149006898 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443149006899 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443149006900 active site 443149006901 metal binding site [ion binding]; metal-binding site 443149006902 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 443149006903 haloalkane dehalogenase; Provisional; Region: PRK03592 443149006904 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443149006905 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443149006906 dimer interface [polypeptide binding]; other site 443149006907 motif 1; other site 443149006908 active site 443149006909 motif 2; other site 443149006910 motif 3; other site 443149006911 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443149006912 anticodon binding site; other site 443149006913 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443149006914 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443149006915 active site 443149006916 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 443149006917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149006918 Zn2+ binding site [ion binding]; other site 443149006919 Mg2+ binding site [ion binding]; other site 443149006920 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443149006921 synthetase active site [active] 443149006922 NTP binding site [chemical binding]; other site 443149006923 metal binding site [ion binding]; metal-binding site 443149006924 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443149006925 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443149006926 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149006927 active site 443149006928 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443149006929 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443149006930 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443149006931 Protein export membrane protein; Region: SecD_SecF; pfam02355 443149006932 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443149006933 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 443149006934 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 443149006935 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443149006936 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149006937 inhibitor-cofactor binding pocket; inhibition site 443149006938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149006939 catalytic residue [active] 443149006940 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443149006941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149006942 acyl-activating enzyme (AAE) consensus motif; other site 443149006943 AMP binding site [chemical binding]; other site 443149006944 active site 443149006945 CoA binding site [chemical binding]; other site 443149006946 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443149006947 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 443149006948 putative NAD(P) binding site [chemical binding]; other site 443149006949 active site 443149006950 putative substrate binding site [chemical binding]; other site 443149006951 PE family; Region: PE; pfam00934 443149006952 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443149006953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149006954 Walker A motif; other site 443149006955 ATP binding site [chemical binding]; other site 443149006956 Walker B motif; other site 443149006957 arginine finger; other site 443149006958 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443149006959 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443149006960 RuvA N terminal domain; Region: RuvA_N; pfam01330 443149006961 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443149006962 active site 443149006963 putative DNA-binding cleft [nucleotide binding]; other site 443149006964 dimer interface [polypeptide binding]; other site 443149006965 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149006966 putative active site [active] 443149006967 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 443149006968 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 443149006969 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 443149006970 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 443149006971 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 443149006972 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 443149006973 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149006974 hypothetical protein; Validated; Region: PRK00110 443149006975 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443149006976 predicted active site [active] 443149006977 catalytic triad [active] 443149006978 acyl-CoA thioesterase II; Region: tesB; TIGR00189 443149006979 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443149006980 active site 443149006981 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443149006982 catalytic triad [active] 443149006983 dimer interface [polypeptide binding]; other site 443149006984 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443149006985 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443149006986 active site 443149006987 multimer interface [polypeptide binding]; other site 443149006988 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 443149006989 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443149006990 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443149006991 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006992 PPE family; Region: PPE; pfam00823 443149006993 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149006994 PE-PPE domain; Region: PE-PPE; pfam08237 443149006995 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 443149006996 nudix motif; other site 443149006997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149006998 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149006999 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443149007000 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443149007001 putative acyl-acceptor binding pocket; other site 443149007002 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149007003 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443149007004 nucleotide binding site/active site [active] 443149007005 HIT family signature motif; other site 443149007006 catalytic residue [active] 443149007007 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443149007008 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 443149007009 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443149007010 active site 443149007011 dimer interface [polypeptide binding]; other site 443149007012 motif 1; other site 443149007013 motif 2; other site 443149007014 motif 3; other site 443149007015 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443149007016 anticodon binding site; other site 443149007017 PE family; Region: PE; pfam00934 443149007018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 443149007019 Helix-turn-helix domain; Region: HTH_20; pfam12840 443149007020 Predicted transcriptional regulator [Transcription]; Region: COG2345 443149007021 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 443149007022 Predicted transcriptional regulator [Transcription]; Region: COG2345 443149007023 Helix-turn-helix domain; Region: HTH_20; pfam12840 443149007024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007025 S-adenosylmethionine binding site [chemical binding]; other site 443149007026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149007027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007028 Ligand Binding Site [chemical binding]; other site 443149007029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007030 Ligand Binding Site [chemical binding]; other site 443149007031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149007032 Ligand Binding Site [chemical binding]; other site 443149007033 Universal stress protein family; Region: Usp; pfam00582 443149007034 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 443149007035 active site 443149007036 Peptidase family M50; Region: Peptidase_M50; pfam02163 443149007037 putative substrate binding region [chemical binding]; other site 443149007038 FOG: CBS domain [General function prediction only]; Region: COG0517 443149007039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 443149007040 FOG: CBS domain [General function prediction only]; Region: COG0517 443149007041 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 443149007042 peptide chain release factor 1; Provisional; Region: PRK04011 443149007043 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 443149007044 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 443149007045 Hemerythrin-like domain; Region: Hr-like; cd12108 443149007046 Fe binding site [ion binding]; other site 443149007047 PE family; Region: PE; pfam00934 443149007048 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 443149007049 P-loop motif; other site 443149007050 ATP binding site [chemical binding]; other site 443149007051 Chloramphenicol (Cm) binding site [chemical binding]; other site 443149007052 catalytic residue [active] 443149007053 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443149007054 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443149007055 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149007056 anti sigma factor interaction site; other site 443149007057 regulatory phosphorylation site [posttranslational modification]; other site 443149007058 hypothetical protein; Provisional; Region: PRK02237 443149007059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443149007061 putative DNA binding site [nucleotide binding]; other site 443149007062 putative Zn2+ binding site [ion binding]; other site 443149007063 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 443149007064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443149007065 putative metal binding site [ion binding]; other site 443149007066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007067 dimerization interface [polypeptide binding]; other site 443149007068 putative DNA binding site [nucleotide binding]; other site 443149007069 putative Zn2+ binding site [ion binding]; other site 443149007070 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443149007071 arsenical-resistance protein; Region: acr3; TIGR00832 443149007072 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443149007073 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443149007074 active site 443149007075 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443149007076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149007077 active site 443149007078 DNA binding site [nucleotide binding] 443149007079 Int/Topo IB signature motif; other site 443149007080 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 443149007081 ParB-like nuclease domain; Region: ParBc; cl02129 443149007082 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 443149007083 Phage capsid family; Region: Phage_capsid; pfam05065 443149007084 phage prohead protease, HK97 family; Region: proheadase_HK97; TIGR01543 443149007085 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 443149007086 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 443149007087 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 443149007088 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 443149007089 active site 443149007090 catalytic residues [active] 443149007091 DNA binding site [nucleotide binding] 443149007092 Int/Topo IB signature motif; other site 443149007093 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149007094 MULE transposase domain; Region: MULE; pfam10551 443149007095 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443149007096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443149007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007098 Coenzyme A binding pocket [chemical binding]; other site 443149007099 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443149007100 hypothetical protein; Provisional; Region: PRK14059 443149007101 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443149007102 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149007103 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149007104 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443149007105 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 443149007106 SelR domain; Region: SelR; pfam01641 443149007107 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149007108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007109 S-adenosylmethionine binding site [chemical binding]; other site 443149007110 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 443149007111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149007112 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443149007113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007114 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443149007115 substrate binding site [chemical binding]; other site 443149007116 active site 443149007117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149007118 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149007119 substrate binding site [chemical binding]; other site 443149007120 oxyanion hole (OAH) forming residues; other site 443149007121 trimer interface [polypeptide binding]; other site 443149007122 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443149007123 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443149007124 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443149007125 catalytic site [active] 443149007126 putative active site [active] 443149007127 putative substrate binding site [chemical binding]; other site 443149007128 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 443149007129 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443149007130 TPP-binding site; other site 443149007131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149007132 PYR/PP interface [polypeptide binding]; other site 443149007133 dimer interface [polypeptide binding]; other site 443149007134 TPP binding site [chemical binding]; other site 443149007135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149007136 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443149007137 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149007138 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443149007139 transmembrane helices; other site 443149007140 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149007141 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 443149007142 transmembrane helices; other site 443149007143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443149007144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443149007145 Walker A/P-loop; other site 443149007146 ATP binding site [chemical binding]; other site 443149007147 Q-loop/lid; other site 443149007148 ABC transporter signature motif; other site 443149007149 Walker B; other site 443149007150 D-loop; other site 443149007151 H-loop/switch region; other site 443149007152 TRAM domain; Region: TRAM; cl01282 443149007153 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443149007154 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443149007155 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149007156 TrkA-N domain; Region: TrkA_N; pfam02254 443149007157 TrkA-C domain; Region: TrkA_C; pfam02080 443149007158 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149007159 TrkA-N domain; Region: TrkA_N; pfam02254 443149007160 TrkA-C domain; Region: TrkA_C; pfam02080 443149007161 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443149007162 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443149007163 generic binding surface II; other site 443149007164 ssDNA binding site; other site 443149007165 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443149007166 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443149007167 trimer interface [polypeptide binding]; other site 443149007168 active site 443149007169 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149007170 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149007171 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443149007172 active site 443149007173 dimerization interface [polypeptide binding]; other site 443149007174 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443149007175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149007176 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443149007177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149007178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149007179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149007180 DNA binding residues [nucleotide binding] 443149007181 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 443149007182 homotrimer interaction site [polypeptide binding]; other site 443149007183 putative active site [active] 443149007184 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 443149007185 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443149007186 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443149007187 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443149007188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149007189 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149007190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149007191 DNA binding residues [nucleotide binding] 443149007192 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443149007193 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 443149007194 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443149007195 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443149007196 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 443149007197 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 443149007198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149007200 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149007201 PAC2 family; Region: PAC2; pfam09754 443149007202 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149007203 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 443149007204 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 443149007205 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443149007206 heme-binding site [chemical binding]; other site 443149007207 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443149007208 ATP cone domain; Region: ATP-cone; pfam03477 443149007209 LexA repressor; Validated; Region: PRK00215 443149007210 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443149007211 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443149007212 Catalytic site [active] 443149007213 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443149007214 LGFP repeat; Region: LGFP; pfam08310 443149007215 LGFP repeat; Region: LGFP; pfam08310 443149007216 LGFP repeat; Region: LGFP; pfam08310 443149007217 LGFP repeat; Region: LGFP; pfam08310 443149007218 LGFP repeat; Region: LGFP; pfam08310 443149007219 Integral membrane protein TerC family; Region: TerC; cl10468 443149007220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149007221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149007222 active site 443149007223 GTPases [General function prediction only]; Region: HflX; COG2262 443149007224 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443149007225 HflX GTPase family; Region: HflX; cd01878 443149007226 G1 box; other site 443149007227 GTP/Mg2+ binding site [chemical binding]; other site 443149007228 Switch I region; other site 443149007229 G2 box; other site 443149007230 G3 box; other site 443149007231 Switch II region; other site 443149007232 G4 box; other site 443149007233 G5 box; other site 443149007234 diaminopimelate epimerase; Region: DapF; TIGR00652 443149007235 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443149007236 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443149007237 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443149007238 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443149007239 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 443149007240 active site 443149007241 metal binding site [ion binding]; metal-binding site 443149007242 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007243 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007244 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443149007245 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443149007246 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443149007247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149007248 FeS/SAM binding site; other site 443149007249 TRAM domain; Region: TRAM; cl01282 443149007250 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 443149007251 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 443149007252 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443149007253 hexamer interface [polypeptide binding]; other site 443149007254 Walker A motif; other site 443149007255 ATP binding site [chemical binding]; other site 443149007256 Walker B motif; other site 443149007257 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 443149007258 protein-splicing catalytic site; other site 443149007259 thioester formation/cholesterol transfer; other site 443149007260 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 443149007261 recA bacterial DNA recombination protein; Region: RecA; cl17211 443149007262 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149007263 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443149007264 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 443149007265 PE family; Region: PE; pfam00934 443149007266 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443149007267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149007268 non-specific DNA binding site [nucleotide binding]; other site 443149007269 salt bridge; other site 443149007270 sequence-specific DNA binding site [nucleotide binding]; other site 443149007271 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 443149007272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007273 Coenzyme A binding pocket [chemical binding]; other site 443149007274 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 443149007275 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149007276 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 443149007277 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443149007278 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 443149007279 classical (c) SDRs; Region: SDR_c; cd05233 443149007280 NAD(P) binding site [chemical binding]; other site 443149007281 active site 443149007282 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149007283 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149007284 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443149007285 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149007286 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443149007287 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443149007288 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443149007289 dimer interface [polypeptide binding]; other site 443149007290 active site 443149007291 catalytic residue [active] 443149007292 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443149007293 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443149007294 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 443149007295 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149007296 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 443149007297 putative active site [active] 443149007298 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 443149007299 putative active site [active] 443149007300 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443149007301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 443149007302 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 443149007303 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443149007304 folate binding site [chemical binding]; other site 443149007305 NADP+ binding site [chemical binding]; other site 443149007306 thymidylate synthase; Reviewed; Region: thyA; PRK01827 443149007307 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 443149007308 dimerization interface [polypeptide binding]; other site 443149007309 active site 443149007310 Dienelactone hydrolase family; Region: DLH; pfam01738 443149007311 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443149007312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149007313 active site 443149007314 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007315 PPE family; Region: PPE; pfam00823 443149007316 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149007317 PE family; Region: PE; pfam00934 443149007318 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149007319 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007320 PPE family; Region: PPE; pfam00823 443149007321 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443149007322 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443149007323 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443149007324 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443149007325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443149007326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149007327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443149007328 Coenzyme A binding pocket [chemical binding]; other site 443149007329 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149007330 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443149007331 FMN-binding pocket [chemical binding]; other site 443149007332 flavin binding motif; other site 443149007333 phosphate binding motif [ion binding]; other site 443149007334 beta-alpha-beta structure motif; other site 443149007335 NAD binding pocket [chemical binding]; other site 443149007336 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149007337 catalytic loop [active] 443149007338 iron binding site [ion binding]; other site 443149007339 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443149007340 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443149007341 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443149007342 hydrophobic ligand binding site; other site 443149007343 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149007344 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443149007345 AsnC family; Region: AsnC_trans_reg; pfam01037 443149007346 alanine dehydrogenase; Region: alaDH; TIGR00518 443149007347 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443149007348 hexamer interface [polypeptide binding]; other site 443149007349 ligand binding site [chemical binding]; other site 443149007350 putative active site [active] 443149007351 NAD(P) binding site [chemical binding]; other site 443149007352 Nitronate monooxygenase; Region: NMO; pfam03060 443149007353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149007354 FMN binding site [chemical binding]; other site 443149007355 substrate binding site [chemical binding]; other site 443149007356 putative catalytic residue [active] 443149007357 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443149007358 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443149007359 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443149007360 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443149007361 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443149007362 oligomer interface [polypeptide binding]; other site 443149007363 RNA binding site [nucleotide binding]; other site 443149007364 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443149007365 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443149007366 RNase E interface [polypeptide binding]; other site 443149007367 trimer interface [polypeptide binding]; other site 443149007368 active site 443149007369 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443149007370 putative nucleic acid binding region [nucleotide binding]; other site 443149007371 G-X-X-G motif; other site 443149007372 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443149007373 RNA binding site [nucleotide binding]; other site 443149007374 domain interface; other site 443149007375 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443149007376 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443149007377 active site 443149007378 Riboflavin kinase; Region: Flavokinase; pfam01687 443149007379 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149007380 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 443149007381 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443149007382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149007383 putative DNA binding site [nucleotide binding]; other site 443149007384 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443149007385 FeoA domain; Region: FeoA; pfam04023 443149007386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149007387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149007388 active site 443149007389 lipid-transfer protein; Provisional; Region: PRK08256 443149007390 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149007391 active site 443149007392 potential frameshift: common BLAST hit: gi|378772526|ref|YP_005172259.1| putative transposase 443149007393 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 443149007394 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149007395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149007396 Probable transposase; Region: OrfB_IS605; pfam01385 443149007397 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149007398 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149007399 catalytic residues [active] 443149007400 catalytic nucleophile [active] 443149007401 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443149007402 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443149007403 RNA binding site [nucleotide binding]; other site 443149007404 active site 443149007405 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443149007406 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443149007407 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443149007408 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443149007409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443149007410 active site 443149007411 metal binding site [ion binding]; metal-binding site 443149007412 Uncharacterized conserved protein [Function unknown]; Region: COG4717 443149007413 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443149007414 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443149007415 potential frameshift: common BLAST hit: gi|378772535|ref|YP_005172268.1| putative hydrolase 443149007416 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 443149007417 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443149007418 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 443149007419 Uncharacterized conserved protein [Function unknown]; Region: COG5586 443149007420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 443149007421 Integrase core domain; Region: rve; pfam00665 443149007422 Helix-turn-helix domain; Region: HTH_28; pfam13518 443149007423 Winged helix-turn helix; Region: HTH_29; pfam13551 443149007424 Integrase core domain; Region: rve; pfam00665 443149007425 Integrase core domain; Region: rve_3; pfam13683 443149007426 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 443149007427 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 443149007428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149007429 Transposase; Region: HTH_Tnp_1; cl17663 443149007430 putative transposase OrfB; Reviewed; Region: PHA02517 443149007431 HTH-like domain; Region: HTH_21; pfam13276 443149007432 Integrase core domain; Region: rve; pfam00665 443149007433 Integrase core domain; Region: rve_3; pfam13683 443149007434 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 443149007435 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 443149007436 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 443149007437 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 443149007438 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 443149007439 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 443149007440 Uncharacterized conserved protein [Function unknown]; Region: COG2253 443149007441 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 443149007442 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 443149007443 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443149007444 putative active site [active] 443149007445 enoyl-CoA hydratase; Provisional; Region: PRK06190 443149007446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149007447 substrate binding site [chemical binding]; other site 443149007448 oxyanion hole (OAH) forming residues; other site 443149007449 trimer interface [polypeptide binding]; other site 443149007450 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443149007451 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443149007452 Walker A/P-loop; other site 443149007453 ATP binding site [chemical binding]; other site 443149007454 Q-loop/lid; other site 443149007455 ABC transporter signature motif; other site 443149007456 Walker B; other site 443149007457 D-loop; other site 443149007458 H-loop/switch region; other site 443149007459 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443149007460 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443149007461 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443149007462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149007463 dimer interface [polypeptide binding]; other site 443149007464 conserved gate region; other site 443149007465 putative PBP binding loops; other site 443149007466 ABC-ATPase subunit interface; other site 443149007467 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443149007468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149007469 dimer interface [polypeptide binding]; other site 443149007470 conserved gate region; other site 443149007471 putative PBP binding loops; other site 443149007472 ABC-ATPase subunit interface; other site 443149007473 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443149007474 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 443149007475 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443149007476 DHH family; Region: DHH; pfam01368 443149007477 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 443149007478 potential frameshift: common BLAST hit: gi|378772574|ref|YP_005172307.1| translation initiation factor IF-2 443149007479 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 443149007480 G4 box; other site 443149007481 G5 box; other site 443149007482 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443149007483 Translation-initiation factor 2; Region: IF-2; pfam11987 443149007484 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443149007485 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443149007486 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443149007487 G1 box; other site 443149007488 putative GEF interaction site [polypeptide binding]; other site 443149007489 GTP/Mg2+ binding site [chemical binding]; other site 443149007490 Switch I region; other site 443149007491 G2 box; other site 443149007492 G3 box; other site 443149007493 Switch II region; other site 443149007494 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443149007495 NusA N-terminal domain; Region: NusA_N; pfam08529 443149007496 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443149007497 RNA binding site [nucleotide binding]; other site 443149007498 homodimer interface [polypeptide binding]; other site 443149007499 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443149007500 G-X-X-G motif; other site 443149007501 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443149007502 G-X-X-G motif; other site 443149007503 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443149007504 Sm and related proteins; Region: Sm_like; cl00259 443149007505 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 443149007506 putative oligomer interface [polypeptide binding]; other site 443149007507 putative RNA binding site [nucleotide binding]; other site 443149007508 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 443149007509 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443149007510 dinuclear metal binding motif [ion binding]; other site 443149007511 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443149007512 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443149007513 dimer interface [polypeptide binding]; other site 443149007514 motif 1; other site 443149007515 active site 443149007516 motif 2; other site 443149007517 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 443149007518 putative deacylase active site [active] 443149007519 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149007520 active site 443149007521 motif 3; other site 443149007522 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443149007523 anticodon binding site; other site 443149007524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149007525 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149007526 putative substrate translocation pore; other site 443149007527 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 443149007528 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 443149007529 homodimer interface [polypeptide binding]; other site 443149007530 active site 443149007531 SAM binding site [chemical binding]; other site 443149007532 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443149007533 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 443149007534 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443149007535 catalytic triad [active] 443149007536 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443149007537 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443149007538 homodimer interface [polypeptide binding]; other site 443149007539 Walker A motif; other site 443149007540 ATP binding site [chemical binding]; other site 443149007541 hydroxycobalamin binding site [chemical binding]; other site 443149007542 Walker B motif; other site 443149007543 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 443149007544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149007545 Walker A motif; other site 443149007546 ATP binding site [chemical binding]; other site 443149007547 Walker B motif; other site 443149007548 arginine finger; other site 443149007549 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 443149007550 metal ion-dependent adhesion site (MIDAS); other site 443149007551 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 443149007552 malate:quinone oxidoreductase; Validated; Region: PRK05257 443149007553 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 443149007554 PE family; Region: PE; pfam00934 443149007555 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443149007556 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149007557 mycothione reductase; Reviewed; Region: PRK07846 443149007558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149007559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149007560 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149007561 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 443149007562 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149007563 short chain dehydrogenase; Provisional; Region: PRK06057 443149007564 classical (c) SDRs; Region: SDR_c; cd05233 443149007565 NAD(P) binding site [chemical binding]; other site 443149007566 active site 443149007567 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149007568 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 443149007569 NAD(P) binding site [chemical binding]; other site 443149007570 catalytic residues [active] 443149007571 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 443149007572 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 443149007573 catalytic triad [active] 443149007574 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443149007575 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443149007576 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443149007577 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443149007578 active site 443149007579 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443149007580 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 443149007581 putative active site [active] 443149007582 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443149007583 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443149007584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443149007585 Predicted acetyltransferase [General function prediction only]; Region: COG3393 443149007586 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 443149007587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443149007588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443149007589 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443149007590 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443149007591 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443149007592 active site 443149007593 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443149007594 protein binding site [polypeptide binding]; other site 443149007595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443149007596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443149007597 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443149007598 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443149007599 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149007600 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443149007601 Fasciclin domain; Region: Fasciclin; pfam02469 443149007602 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149007603 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443149007604 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 443149007605 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149007606 catalytic residues [active] 443149007607 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 443149007608 Fasciclin domain; Region: Fasciclin; pfam02469 443149007609 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 443149007610 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443149007611 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 443149007612 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149007613 catalytic residues [active] 443149007614 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 443149007615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149007616 FeS/SAM binding site; other site 443149007617 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443149007618 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443149007619 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443149007620 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443149007621 hinge region; other site 443149007622 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443149007623 putative nucleotide binding site [chemical binding]; other site 443149007624 uridine monophosphate binding site [chemical binding]; other site 443149007625 homohexameric interface [polypeptide binding]; other site 443149007626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149007627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149007628 DNA binding site [nucleotide binding] 443149007629 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149007630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149007631 Probable transposase; Region: OrfB_IS605; pfam01385 443149007632 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149007633 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443149007634 catalytic residues [active] 443149007635 catalytic nucleophile [active] 443149007636 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443149007637 MarR family; Region: MarR; pfam01047 443149007638 amidase; Provisional; Region: PRK07869 443149007639 Amidase; Region: Amidase; pfam01425 443149007640 elongation factor Ts; Provisional; Region: tsf; PRK09377 443149007641 UBA/TS-N domain; Region: UBA; pfam00627 443149007642 Elongation factor TS; Region: EF_TS; pfam00889 443149007643 Elongation factor TS; Region: EF_TS; pfam00889 443149007644 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443149007645 rRNA interaction site [nucleotide binding]; other site 443149007646 S8 interaction site; other site 443149007647 putative laminin-1 binding site; other site 443149007648 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149007649 PPE family; Region: PPE; pfam00823 443149007650 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149007651 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 443149007652 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149007653 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443149007654 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443149007655 active site 443149007656 DNA binding site [nucleotide binding] 443149007657 Int/Topo IB signature motif; other site 443149007658 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443149007659 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443149007660 FAD binding pocket [chemical binding]; other site 443149007661 FAD binding motif [chemical binding]; other site 443149007662 phosphate binding motif [ion binding]; other site 443149007663 NAD binding pocket [chemical binding]; other site 443149007664 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 443149007665 DNA protecting protein DprA; Region: dprA; TIGR00732 443149007666 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443149007667 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443149007668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149007669 Walker A motif; other site 443149007670 ATP binding site [chemical binding]; other site 443149007671 Walker B motif; other site 443149007672 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443149007673 hypothetical protein; Reviewed; Region: PRK12497 443149007674 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 443149007675 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 443149007676 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 443149007677 putative molybdopterin cofactor binding site [chemical binding]; other site 443149007678 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 443149007679 putative molybdopterin cofactor binding site; other site 443149007680 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443149007681 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443149007682 RNA/DNA hybrid binding site [nucleotide binding]; other site 443149007683 active site 443149007684 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443149007685 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443149007686 Catalytic site [active] 443149007687 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443149007688 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443149007689 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149007690 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443149007691 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443149007692 RimM N-terminal domain; Region: RimM; pfam01782 443149007693 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 443149007694 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443149007695 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443149007696 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149007697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149007698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149007699 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 443149007700 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 443149007701 active site 443149007702 putative substrate binding pocket [chemical binding]; other site 443149007703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443149007704 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149007705 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149007706 active site 443149007707 ATP binding site [chemical binding]; other site 443149007708 substrate binding site [chemical binding]; other site 443149007709 activation loop (A-loop); other site 443149007710 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443149007711 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 443149007712 active site 443149007713 signal recognition particle protein; Provisional; Region: PRK10867 443149007714 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443149007715 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443149007716 P loop; other site 443149007717 GTP binding site [chemical binding]; other site 443149007718 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443149007719 potential frameshift: common BLAST hit: gi|375295264|ref|YP_005099531.1| conserved alanine and arginine rich protein 443149007720 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443149007721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149007722 ATP binding site [chemical binding]; other site 443149007723 putative Mg++ binding site [ion binding]; other site 443149007724 potential frameshift: common BLAST hit: gi|339632924|ref|YP_004724566.1| PII uridylyltransferase 443149007725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149007726 Zn2+ binding site [ion binding]; other site 443149007727 Mg2+ binding site [ion binding]; other site 443149007728 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443149007729 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443149007730 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443149007731 metal binding triad [ion binding]; metal-binding site 443149007732 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443149007733 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 443149007734 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443149007735 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443149007736 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 443149007737 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443149007738 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443149007739 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443149007740 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 443149007741 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443149007742 ABC transporter signature motif; other site 443149007743 Walker B; other site 443149007744 D-loop; other site 443149007745 H-loop/switch region; other site 443149007746 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443149007747 AAA domain; Region: AAA_23; pfam13476 443149007748 Walker A/P-loop; other site 443149007749 ATP binding site [chemical binding]; other site 443149007750 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 443149007751 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443149007752 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443149007753 DNA binding site [nucleotide binding] 443149007754 catalytic residue [active] 443149007755 H2TH interface [polypeptide binding]; other site 443149007756 putative catalytic residues [active] 443149007757 turnover-facilitating residue; other site 443149007758 intercalation triad [nucleotide binding]; other site 443149007759 8OG recognition residue [nucleotide binding]; other site 443149007760 putative reading head residues; other site 443149007761 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149007762 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443149007763 ribonuclease III; Reviewed; Region: rnc; PRK00102 443149007764 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443149007765 dimerization interface [polypeptide binding]; other site 443149007766 active site 443149007767 metal binding site [ion binding]; metal-binding site 443149007768 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443149007769 dsRNA binding site [nucleotide binding]; other site 443149007770 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 443149007771 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443149007772 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 443149007773 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443149007774 acyl-CoA synthetase; Validated; Region: PRK05850 443149007775 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149007776 acyl-activating enzyme (AAE) consensus motif; other site 443149007777 active site 443149007778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149007779 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149007780 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007781 active site 443149007782 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149007783 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149007784 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149007785 NADP binding site [chemical binding]; other site 443149007786 KR domain; Region: KR; pfam08659 443149007787 active site 443149007788 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007789 potential frameshift: common BLAST hit: gi|375295249|ref|YP_005099516.1| polyketide synthase 443149007790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007791 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149007792 active site 443149007793 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443149007794 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 443149007795 KR domain; Region: KR; pfam08659 443149007796 NADP binding site [chemical binding]; other site 443149007797 active site 443149007798 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007799 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149007800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007801 active site 443149007802 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443149007803 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149007804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149007805 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149007806 Enoylreductase; Region: PKS_ER; smart00829 443149007807 NAD(P) binding site [chemical binding]; other site 443149007808 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149007809 KR domain; Region: KR; pfam08659 443149007810 putative NADP binding site [chemical binding]; other site 443149007811 active site 443149007812 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007813 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149007814 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007815 active site 443149007816 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149007817 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149007818 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149007819 KR domain; Region: KR; pfam08659 443149007820 putative NADP binding site [chemical binding]; other site 443149007821 active site 443149007822 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007823 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149007824 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007825 active site 443149007826 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149007827 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443149007828 Condensation domain; Region: Condensation; pfam00668 443149007829 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443149007830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149007831 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443149007832 Walker A/P-loop; other site 443149007833 ATP binding site [chemical binding]; other site 443149007834 Q-loop/lid; other site 443149007835 ABC transporter signature motif; other site 443149007836 Walker B; other site 443149007837 D-loop; other site 443149007838 H-loop/switch region; other site 443149007839 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149007840 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149007841 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 443149007842 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443149007843 acyltransferase PapA5; Provisional; Region: PRK09294 443149007844 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443149007845 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007846 active site 443149007847 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 443149007848 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149007849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149007850 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149007851 Enoylreductase; Region: PKS_ER; smart00829 443149007852 NAD(P) binding site [chemical binding]; other site 443149007853 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149007854 KR domain; Region: KR; pfam08659 443149007855 putative NADP binding site [chemical binding]; other site 443149007856 active site 443149007857 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007858 acyl-CoA synthetase; Validated; Region: PRK05850 443149007859 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149007860 acyl-activating enzyme (AAE) consensus motif; other site 443149007861 active site 443149007862 MMPL family; Region: MMPL; pfam03176 443149007863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149007864 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443149007865 Integrase core domain; Region: rve; pfam00665 443149007866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443149007867 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 443149007868 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149007869 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149007870 active site 443149007871 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149007872 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149007873 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149007874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149007875 Enoylreductase; Region: PKS_ER; smart00829 443149007876 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149007877 NAD(P) binding site [chemical binding]; other site 443149007878 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 443149007879 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 443149007880 putative NADP binding site [chemical binding]; other site 443149007881 active site 443149007882 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007883 Erythronolide synthase docking; Region: Docking; pfam08990 443149007884 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443149007885 acyl-CoA synthetase; Validated; Region: PRK06060 443149007886 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 443149007887 dimer interface [polypeptide binding]; other site 443149007888 acyl-activating enzyme (AAE) consensus motif; other site 443149007889 putative active site [active] 443149007890 putative AMP binding site [chemical binding]; other site 443149007891 putative CoA binding site [chemical binding]; other site 443149007892 chemical substrate binding site [chemical binding]; other site 443149007893 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149007894 acyl-CoA synthetase; Validated; Region: PRK05850 443149007895 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149007896 acyl-activating enzyme (AAE) consensus motif; other site 443149007897 active site 443149007898 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149007899 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149007900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007901 S-adenosylmethionine binding site [chemical binding]; other site 443149007902 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443149007903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149007904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007905 S-adenosylmethionine binding site [chemical binding]; other site 443149007906 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 443149007907 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 443149007908 metal-binding site 443149007909 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149007910 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149007911 active site 443149007912 TDP-binding site; other site 443149007913 acceptor substrate-binding pocket; other site 443149007914 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 443149007915 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149007916 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443149007917 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443149007918 active site 443149007919 TDP-binding site; other site 443149007920 Predicted permease; Region: DUF318; pfam03773 443149007921 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 443149007922 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443149007923 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443149007924 putative active site [active] 443149007925 putative substrate binding site [chemical binding]; other site 443149007926 putative cosubstrate binding site; other site 443149007927 catalytic site [active] 443149007928 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443149007929 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443149007930 active site 443149007931 (T/H)XGH motif; other site 443149007932 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 443149007933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149007934 S-adenosylmethionine binding site [chemical binding]; other site 443149007935 pyruvate carboxylase; Reviewed; Region: PRK12999 443149007936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149007937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443149007938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149007939 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443149007940 active site 443149007941 catalytic residues [active] 443149007942 metal binding site [ion binding]; metal-binding site 443149007943 homodimer binding site [polypeptide binding]; other site 443149007944 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149007945 carboxyltransferase (CT) interaction site; other site 443149007946 biotinylation site [posttranslational modification]; other site 443149007947 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443149007948 putative active site [active] 443149007949 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443149007950 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443149007951 catalytic residues [active] 443149007952 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443149007953 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149007954 substrate binding pocket [chemical binding]; other site 443149007955 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443149007956 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443149007957 active site 443149007958 catalytic tetrad [active] 443149007959 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443149007960 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 443149007961 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443149007962 generic binding surface II; other site 443149007963 ssDNA binding site; other site 443149007964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149007965 ATP binding site [chemical binding]; other site 443149007966 putative Mg++ binding site [ion binding]; other site 443149007967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149007968 nucleotide binding region [chemical binding]; other site 443149007969 ATP-binding site [chemical binding]; other site 443149007970 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 443149007971 DAK2 domain; Region: Dak2; cl03685 443149007972 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443149007973 ligand binding site [chemical binding]; other site 443149007974 active site 443149007975 UGI interface [polypeptide binding]; other site 443149007976 catalytic site [active] 443149007977 thiamine monophosphate kinase; Provisional; Region: PRK05731 443149007978 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443149007979 ATP binding site [chemical binding]; other site 443149007980 dimerization interface [polypeptide binding]; other site 443149007981 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149007982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149007983 Probable transposase; Region: OrfB_IS605; pfam01385 443149007984 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149007985 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443149007986 catalytic residues [active] 443149007987 catalytic nucleophile [active] 443149007988 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443149007989 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443149007990 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443149007991 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 443149007992 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443149007993 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443149007994 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443149007995 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 443149007996 polyphosphate kinase; Provisional; Region: PRK05443 443149007997 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443149007998 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443149007999 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443149008000 putative domain interface [polypeptide binding]; other site 443149008001 putative active site [active] 443149008002 catalytic site [active] 443149008003 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443149008004 putative domain interface [polypeptide binding]; other site 443149008005 putative active site [active] 443149008006 catalytic site [active] 443149008007 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443149008008 active site 443149008009 Ap6A binding site [chemical binding]; other site 443149008010 nudix motif; other site 443149008011 metal binding site [ion binding]; metal-binding site 443149008012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149008013 catalytic core [active] 443149008014 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443149008015 IHF - DNA interface [nucleotide binding]; other site 443149008016 IHF dimer interface [polypeptide binding]; other site 443149008017 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443149008018 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443149008019 substrate binding site [chemical binding]; other site 443149008020 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443149008021 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443149008022 substrate binding site [chemical binding]; other site 443149008023 ligand binding site [chemical binding]; other site 443149008024 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 443149008025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443149008026 Bacterial transcriptional regulator; Region: IclR; pfam01614 443149008027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008028 S-adenosylmethionine binding site [chemical binding]; other site 443149008029 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 443149008030 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 443149008031 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443149008032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149008033 active site 443149008034 HIGH motif; other site 443149008035 nucleotide binding site [chemical binding]; other site 443149008036 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443149008037 active site 443149008038 KMSKS motif; other site 443149008039 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443149008040 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443149008041 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443149008042 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 443149008043 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443149008044 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443149008045 ligand binding site [chemical binding]; other site 443149008046 NAD binding site [chemical binding]; other site 443149008047 dimerization interface [polypeptide binding]; other site 443149008048 catalytic site [active] 443149008049 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443149008050 putative L-serine binding site [chemical binding]; other site 443149008051 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149008052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149008053 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149008054 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 443149008055 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 443149008056 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443149008057 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443149008058 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443149008059 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443149008060 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443149008061 putative valine binding site [chemical binding]; other site 443149008062 dimer interface [polypeptide binding]; other site 443149008063 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443149008064 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443149008065 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149008066 PYR/PP interface [polypeptide binding]; other site 443149008067 dimer interface [polypeptide binding]; other site 443149008068 TPP binding site [chemical binding]; other site 443149008069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149008070 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443149008071 TPP-binding site [chemical binding]; other site 443149008072 dimer interface [polypeptide binding]; other site 443149008073 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443149008074 Predicted membrane protein [Function unknown]; Region: COG2259 443149008075 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 443149008076 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149008077 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 443149008078 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443149008079 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443149008080 GatB domain; Region: GatB_Yqey; smart00845 443149008081 6-phosphofructokinase; Provisional; Region: PRK03202 443149008082 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443149008083 active site 443149008084 ADP/pyrophosphate binding site [chemical binding]; other site 443149008085 dimerization interface [polypeptide binding]; other site 443149008086 allosteric effector site; other site 443149008087 fructose-1,6-bisphosphate binding site; other site 443149008088 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443149008089 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443149008090 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 443149008091 potential frameshift: common BLAST hit: gi|378772753|ref|YP_005172486.1| DNA ligase 443149008092 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443149008093 Dimer interface [polypeptide binding]; other site 443149008094 Ligase N family; Region: LIGANc; smart00532 443149008095 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443149008096 nucleotide binding pocket [chemical binding]; other site 443149008097 K-X-D-G motif; other site 443149008098 catalytic site [active] 443149008099 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443149008100 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443149008101 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 443149008102 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149008103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149008104 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008105 PPE family; Region: PPE; pfam00823 443149008106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008107 Transposase; Region: HTH_Tnp_1; cl17663 443149008108 putative transposase OrfB; Reviewed; Region: PHA02517 443149008109 HTH-like domain; Region: HTH_21; pfam13276 443149008110 Integrase core domain; Region: rve; pfam00665 443149008111 Integrase core domain; Region: rve_3; pfam13683 443149008112 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008113 PPE family; Region: PPE; pfam00823 443149008114 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149008115 MULE transposase domain; Region: MULE; pfam10551 443149008116 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443149008117 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443149008118 Ligand Binding Site [chemical binding]; other site 443149008119 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 443149008120 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443149008121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149008122 catalytic residue [active] 443149008123 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149008124 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149008125 putative acyl-acceptor binding pocket; other site 443149008126 Putative hemolysin [General function prediction only]; Region: COG3176 443149008127 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443149008128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443149008129 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443149008130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443149008131 Ligand binding site [chemical binding]; other site 443149008132 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443149008133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008134 S-adenosylmethionine binding site [chemical binding]; other site 443149008135 Uncharacterized conserved protein [Function unknown]; Region: COG1543 443149008136 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 443149008137 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 443149008138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443149008139 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443149008140 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149008141 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443149008142 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443149008143 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443149008144 trimer interface [polypeptide binding]; other site 443149008145 active site 443149008146 substrate binding site [chemical binding]; other site 443149008147 CoA binding site [chemical binding]; other site 443149008148 FOG: WD40-like repeat [Function unknown]; Region: COG1520 443149008149 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 443149008150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008151 S-adenosylmethionine binding site [chemical binding]; other site 443149008152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149008153 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443149008154 substrate binding site [chemical binding]; other site 443149008155 oxyanion hole (OAH) forming residues; other site 443149008156 trimer interface [polypeptide binding]; other site 443149008157 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 443149008158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149008159 Walker A/P-loop; other site 443149008160 ATP binding site [chemical binding]; other site 443149008161 Q-loop/lid; other site 443149008162 ABC transporter signature motif; other site 443149008163 Walker B; other site 443149008164 D-loop; other site 443149008165 H-loop/switch region; other site 443149008166 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 443149008167 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 443149008168 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149008169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149008170 motif II; other site 443149008171 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443149008172 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443149008173 D-pathway; other site 443149008174 Putative ubiquinol binding site [chemical binding]; other site 443149008175 Low-spin heme (heme b) binding site [chemical binding]; other site 443149008176 Putative water exit pathway; other site 443149008177 Binuclear center (heme o3/CuB) [ion binding]; other site 443149008178 K-pathway; other site 443149008179 Putative proton exit pathway; other site 443149008180 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443149008181 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443149008182 siderophore binding site; other site 443149008183 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443149008184 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443149008185 putative NAD(P) binding site [chemical binding]; other site 443149008186 putative substrate binding site [chemical binding]; other site 443149008187 catalytic Zn binding site [ion binding]; other site 443149008188 structural Zn binding site [ion binding]; other site 443149008189 dimer interface [polypeptide binding]; other site 443149008190 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443149008191 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443149008192 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443149008193 dimer interface [polypeptide binding]; other site 443149008194 putative radical transfer pathway; other site 443149008195 diiron center [ion binding]; other site 443149008196 tyrosyl radical; other site 443149008197 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149008198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149008199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008201 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 443149008202 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443149008203 active site 443149008204 dimer interface [polypeptide binding]; other site 443149008205 catalytic residues [active] 443149008206 effector binding site; other site 443149008207 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 443149008208 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443149008209 Predicted flavoprotein [General function prediction only]; Region: COG0431 443149008210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008211 DNA polymerase IV; Validated; Region: PRK03352 443149008212 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443149008213 DNA binding site [nucleotide binding] 443149008214 short chain dehydrogenase; Provisional; Region: PRK07832 443149008215 classical (c) SDRs; Region: SDR_c; cd05233 443149008216 NAD(P) binding site [chemical binding]; other site 443149008217 active site 443149008218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008220 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149008221 Cytochrome P450; Region: p450; cl12078 443149008222 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149008223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149008224 DNA-binding site [nucleotide binding]; DNA binding site 443149008225 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 443149008226 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443149008227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443149008228 DNA-binding site [nucleotide binding]; DNA binding site 443149008229 FCD domain; Region: FCD; pfam07729 443149008230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008231 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149008232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008236 active site 443149008237 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 443149008238 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 443149008239 active site 443149008240 DNA binding site [nucleotide binding] 443149008241 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 443149008242 DNA binding site [nucleotide binding] 443149008243 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 443149008244 Carbon starvation protein CstA; Region: CstA; pfam02554 443149008245 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 443149008246 DoxX; Region: DoxX; pfam07681 443149008247 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 443149008248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443149008249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008250 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149008251 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 443149008252 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 443149008253 active site 443149008254 substrate binding site [chemical binding]; other site 443149008255 metal binding site [ion binding]; metal-binding site 443149008256 camphor resistance protein CrcB; Provisional; Region: PRK14216 443149008257 camphor resistance protein CrcB; Provisional; Region: PRK14228 443149008258 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443149008259 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443149008260 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 443149008261 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008262 Uncharacterized conserved protein [Function unknown]; Region: COG3189 443149008263 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149008264 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149008265 active site 443149008266 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 443149008267 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 443149008268 putative hydrophobic ligand binding site [chemical binding]; other site 443149008269 protein interface [polypeptide binding]; other site 443149008270 gate; other site 443149008271 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149008272 Sulfatase; Region: Sulfatase; pfam00884 443149008273 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443149008274 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008275 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443149008276 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443149008277 active site 443149008278 ATP binding site [chemical binding]; other site 443149008279 substrate binding site [chemical binding]; other site 443149008280 activation loop (A-loop); other site 443149008281 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443149008282 AAA ATPase domain; Region: AAA_16; pfam13191 443149008283 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 443149008284 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149008285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149008286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149008287 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149008288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149008289 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443149008290 short chain dehydrogenase; Provisional; Region: PRK07832 443149008291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008292 NAD(P) binding site [chemical binding]; other site 443149008293 active site 443149008294 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 443149008295 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443149008296 NAD binding site [chemical binding]; other site 443149008297 catalytic Zn binding site [ion binding]; other site 443149008298 substrate binding site [chemical binding]; other site 443149008299 structural Zn binding site [ion binding]; other site 443149008300 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008301 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008302 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008303 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008304 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149008305 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443149008306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149008307 acyl-activating enzyme (AAE) consensus motif; other site 443149008308 AMP binding site [chemical binding]; other site 443149008309 active site 443149008310 CoA binding site [chemical binding]; other site 443149008311 SPFH domain / Band 7 family; Region: Band_7; pfam01145 443149008312 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443149008313 Patatin-like phospholipase; Region: Patatin; pfam01734 443149008314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 443149008315 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 443149008316 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149008317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008319 active site 443149008320 Predicted transcriptional regulators [Transcription]; Region: COG1733 443149008321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149008322 dimerization interface [polypeptide binding]; other site 443149008323 putative DNA binding site [nucleotide binding]; other site 443149008324 putative Zn2+ binding site [ion binding]; other site 443149008325 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 443149008326 PE family; Region: PE; pfam00934 443149008327 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149008328 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149008329 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149008330 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443149008331 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443149008332 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443149008333 SmpB-tmRNA interface; other site 443149008334 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443149008335 FtsX-like permease family; Region: FtsX; pfam02687 443149008336 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443149008337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443149008338 Walker A/P-loop; other site 443149008339 ATP binding site [chemical binding]; other site 443149008340 Q-loop/lid; other site 443149008341 ABC transporter signature motif; other site 443149008342 Walker B; other site 443149008343 D-loop; other site 443149008344 H-loop/switch region; other site 443149008345 potential frameshift: common BLAST hit: gi|383308846|ref|YP_005361657.1| mechanosensitive ion channel protein MscS 443149008346 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443149008347 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443149008348 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443149008349 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443149008350 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443149008351 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443149008352 RF-1 domain; Region: RF-1; pfam00472 443149008353 ferredoxin-NADP+ reductase; Region: PLN02852 443149008354 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149008355 FAD binding domain; Region: FAD_binding_4; pfam01565 443149008356 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443149008357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008358 FeS/SAM binding site; other site 443149008359 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149008360 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149008361 trimer interface [polypeptide binding]; other site 443149008362 dimer interface [polypeptide binding]; other site 443149008363 putative active site [active] 443149008364 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443149008365 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149008366 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149008367 MULE transposase domain; Region: MULE; pfam10551 443149008368 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443149008369 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443149008370 ATP binding site [chemical binding]; other site 443149008371 substrate interface [chemical binding]; other site 443149008372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149008373 active site residue [active] 443149008374 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149008375 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149008376 active site residue [active] 443149008377 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149008378 active site residue [active] 443149008379 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443149008380 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149008381 MoaE homodimer interface [polypeptide binding]; other site 443149008382 MoaD interaction [polypeptide binding]; other site 443149008383 active site residues [active] 443149008384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008385 S-adenosylmethionine binding site [chemical binding]; other site 443149008386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149008387 Cytochrome P450; Region: p450; cl12078 443149008388 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149008389 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149008390 DNA binding site [nucleotide binding] 443149008391 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008392 PPE family; Region: PPE; pfam00823 443149008393 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008394 putative transposase OrfB; Reviewed; Region: PHA02517 443149008395 HTH-like domain; Region: HTH_21; pfam13276 443149008396 Integrase core domain; Region: rve; pfam00665 443149008397 Integrase core domain; Region: rve_3; pfam13683 443149008398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008399 Transposase; Region: HTH_Tnp_1; cl17663 443149008400 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 443149008401 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008402 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008403 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008404 dimer interface [polypeptide binding]; other site 443149008405 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443149008406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443149008407 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 443149008408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443149008409 Histidine kinase; Region: HisKA_3; pfam07730 443149008410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149008411 ATP binding site [chemical binding]; other site 443149008412 Mg2+ binding site [ion binding]; other site 443149008413 G-X-G motif; other site 443149008414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443149008415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149008416 active site 443149008417 phosphorylation site [posttranslational modification] 443149008418 intermolecular recognition site; other site 443149008419 dimerization interface [polypeptide binding]; other site 443149008420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443149008421 DNA binding residues [nucleotide binding] 443149008422 dimerization interface [polypeptide binding]; other site 443149008423 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443149008424 Ligand Binding Site [chemical binding]; other site 443149008425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008426 PPE family; Region: PPE; pfam00823 443149008427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008428 PPE family; Region: PPE; pfam00823 443149008429 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149008430 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443149008431 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 443149008432 active site 443149008433 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 443149008434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008435 FeS/SAM binding site; other site 443149008436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008438 active site 443149008439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149008441 active site 443149008442 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443149008443 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443149008444 NAD(P) binding site [chemical binding]; other site 443149008445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149008446 active site 443149008447 phosphorylation site [posttranslational modification] 443149008448 intermolecular recognition site; other site 443149008449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008450 PPE family; Region: PPE; pfam00823 443149008451 NADH dehydrogenase subunit A; Validated; Region: PRK07928 443149008452 NADH dehydrogenase subunit B; Validated; Region: PRK06411 443149008453 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 443149008454 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 443149008455 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 443149008456 NADH dehydrogenase subunit D; Validated; Region: PRK06075 443149008457 NADH dehydrogenase subunit E; Validated; Region: PRK07539 443149008458 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443149008459 putative dimer interface [polypeptide binding]; other site 443149008460 [2Fe-2S] cluster binding site [ion binding]; other site 443149008461 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 443149008462 SLBB domain; Region: SLBB; pfam10531 443149008463 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 443149008464 NADH dehydrogenase subunit G; Validated; Region: PRK07860 443149008465 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149008466 catalytic loop [active] 443149008467 iron binding site [ion binding]; other site 443149008468 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 443149008469 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 443149008470 [4Fe-4S] binding site [ion binding]; other site 443149008471 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 443149008472 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 443149008473 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 443149008474 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 443149008475 4Fe-4S binding domain; Region: Fer4; pfam00037 443149008476 4Fe-4S binding domain; Region: Fer4; pfam00037 443149008477 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443149008478 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443149008479 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443149008480 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008481 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443149008482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008483 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443149008484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443149008485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008486 PPE family; Region: PPE; pfam00823 443149008487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149008488 PPE family; Region: PPE; pfam00823 443149008489 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 443149008490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008491 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443149008492 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443149008493 [2Fe-2S] cluster binding site [ion binding]; other site 443149008494 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 443149008495 putative alpha subunit interface [polypeptide binding]; other site 443149008496 putative active site [active] 443149008497 putative substrate binding site [chemical binding]; other site 443149008498 Fe binding site [ion binding]; other site 443149008499 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149008500 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149008501 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149008502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149008503 Walker A motif; other site 443149008504 ATP binding site [chemical binding]; other site 443149008505 Walker B motif; other site 443149008506 arginine finger; other site 443149008507 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443149008508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008510 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443149008511 putative active site [active] 443149008512 putative substrate binding site [chemical binding]; other site 443149008513 ATP binding site [chemical binding]; other site 443149008514 Phosphotransferase enzyme family; Region: APH; pfam01636 443149008515 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 443149008516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149008517 hydroxyglutarate oxidase; Provisional; Region: PRK11728 443149008518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008519 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149008520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008522 short chain dehydrogenase; Validated; Region: PRK08264 443149008523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149008524 NAD(P) binding site [chemical binding]; other site 443149008525 active site 443149008526 Amidase; Region: Amidase; cl11426 443149008527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443149008528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008529 TAP-like protein; Region: Abhydrolase_4; pfam08386 443149008530 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149008531 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 443149008532 AAA domain; Region: AAA_14; pfam13173 443149008533 HTH-like domain; Region: HTH_21; pfam13276 443149008534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008535 Transposase; Region: HTH_Tnp_1; cl17663 443149008536 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 443149008537 putative active site [active] 443149008538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 443149008539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443149008540 non-specific DNA binding site [nucleotide binding]; other site 443149008541 salt bridge; other site 443149008542 sequence-specific DNA binding site [nucleotide binding]; other site 443149008543 Winged helix-turn helix; Region: HTH_29; pfam13551 443149008544 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443149008545 Helix-turn-helix domain; Region: HTH_38; pfam13936 443149008546 Integrase core domain; Region: rve; pfam00665 443149008547 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 443149008548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149008549 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443149008550 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443149008551 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 443149008552 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443149008553 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 443149008554 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443149008555 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443149008556 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443149008557 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 443149008558 ABC1 family; Region: ABC1; pfam03109 443149008559 Phosphotransferase enzyme family; Region: APH; pfam01636 443149008560 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443149008561 active site 443149008562 ATP binding site [chemical binding]; other site 443149008563 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443149008564 Part of AAA domain; Region: AAA_19; pfam13245 443149008565 Family description; Region: UvrD_C_2; pfam13538 443149008566 HRDC domain; Region: HRDC; pfam00570 443149008567 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443149008568 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443149008569 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443149008570 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443149008571 putative NADH binding site [chemical binding]; other site 443149008572 putative active site [active] 443149008573 nudix motif; other site 443149008574 putative metal binding site [ion binding]; other site 443149008575 Ion channel; Region: Ion_trans_2; pfam07885 443149008576 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443149008577 TrkA-N domain; Region: TrkA_N; pfam02254 443149008578 potential frameshift: common BLAST hit: gi|378772944|ref|YP_005172677.1| ATP-dependent DNA helicase 443149008579 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149008580 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443149008581 Part of AAA domain; Region: AAA_19; pfam13245 443149008582 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443149008583 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443149008584 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 443149008585 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008586 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149008587 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149008588 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443149008589 active site 443149008590 DNA binding site [nucleotide binding] 443149008591 TIGR02569 family protein; Region: TIGR02569_actnb 443149008592 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443149008593 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443149008594 ATP binding site [chemical binding]; other site 443149008595 substrate interface [chemical binding]; other site 443149008596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443149008597 active site residue [active] 443149008598 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 443149008599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008601 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 443149008602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443149008603 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443149008604 ATP binding site [chemical binding]; other site 443149008605 Mg++ binding site [ion binding]; other site 443149008606 motif III; other site 443149008607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149008608 nucleotide binding region [chemical binding]; other site 443149008609 ATP-binding site [chemical binding]; other site 443149008610 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149008611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149008612 P-loop; other site 443149008613 Magnesium ion binding site [ion binding]; other site 443149008614 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149008615 Magnesium ion binding site [ion binding]; other site 443149008616 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149008617 catalytic core [active] 443149008618 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443149008619 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443149008620 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443149008621 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443149008622 PAS domain S-box; Region: sensory_box; TIGR00229 443149008623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443149008624 Histidine kinase; Region: HisKA_2; pfam07568 443149008625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149008626 ATP binding site [chemical binding]; other site 443149008627 Mg2+ binding site [ion binding]; other site 443149008628 G-X-G motif; other site 443149008629 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 443149008630 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443149008631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149008632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149008633 DNA binding residues [nucleotide binding] 443149008634 short chain dehydrogenase; Provisional; Region: PRK08278 443149008635 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 443149008636 NAD(P) binding site [chemical binding]; other site 443149008637 homodimer interface [polypeptide binding]; other site 443149008638 active site 443149008639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443149008640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443149008641 Coenzyme A binding pocket [chemical binding]; other site 443149008642 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 443149008643 Phosphotransferase enzyme family; Region: APH; pfam01636 443149008644 putative active site [active] 443149008645 putative substrate binding site [chemical binding]; other site 443149008646 ATP binding site [chemical binding]; other site 443149008647 Uncharacterized conserved protein [Function unknown]; Region: COG2135 443149008648 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443149008649 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443149008650 hinge; other site 443149008651 active site 443149008652 Predicted GTPases [General function prediction only]; Region: COG1162 443149008653 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443149008654 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443149008655 GTP/Mg2+ binding site [chemical binding]; other site 443149008656 G4 box; other site 443149008657 G5 box; other site 443149008658 G1 box; other site 443149008659 Switch I region; other site 443149008660 G2 box; other site 443149008661 G3 box; other site 443149008662 Switch II region; other site 443149008663 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443149008664 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443149008665 putative di-iron ligands [ion binding]; other site 443149008666 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443149008667 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149008668 FAD binding pocket [chemical binding]; other site 443149008669 FAD binding motif [chemical binding]; other site 443149008670 phosphate binding motif [ion binding]; other site 443149008671 beta-alpha-beta structure motif; other site 443149008672 NAD binding pocket [chemical binding]; other site 443149008673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149008674 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443149008675 catalytic loop [active] 443149008676 iron binding site [ion binding]; other site 443149008677 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 443149008678 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149008679 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149008680 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 443149008681 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443149008682 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 443149008683 TrkA-C domain; Region: TrkA_C; pfam02080 443149008684 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443149008685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149008686 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149008687 putative substrate translocation pore; other site 443149008688 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149008689 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149008690 ligand binding site [chemical binding]; other site 443149008691 flexible hinge region; other site 443149008692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 443149008693 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443149008694 nucleophile elbow; other site 443149008695 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443149008696 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443149008697 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443149008698 30S subunit binding site; other site 443149008699 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443149008700 active site 443149008701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443149008702 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443149008703 lipoprotein LpqB; Provisional; Region: PRK13616 443149008704 Sporulation and spore germination; Region: Germane; pfam10646 443149008705 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443149008706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149008707 dimerization interface [polypeptide binding]; other site 443149008708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149008709 dimer interface [polypeptide binding]; other site 443149008710 phosphorylation site [posttranslational modification] 443149008711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149008712 ATP binding site [chemical binding]; other site 443149008713 Mg2+ binding site [ion binding]; other site 443149008714 G-X-G motif; other site 443149008715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149008716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149008717 active site 443149008718 phosphorylation site [posttranslational modification] 443149008719 intermolecular recognition site; other site 443149008720 dimerization interface [polypeptide binding]; other site 443149008721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149008722 DNA binding site [nucleotide binding] 443149008723 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 443149008724 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443149008725 TMP-binding site; other site 443149008726 ATP-binding site [chemical binding]; other site 443149008727 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443149008728 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443149008729 homotetramer interface [polypeptide binding]; other site 443149008730 ligand binding site [chemical binding]; other site 443149008731 catalytic site [active] 443149008732 NAD binding site [chemical binding]; other site 443149008733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008734 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 443149008735 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443149008736 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443149008737 Di-iron ligands [ion binding]; other site 443149008738 amino acid transporter; Region: 2A0306; TIGR00909 443149008739 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443149008740 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443149008741 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 443149008742 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443149008743 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443149008744 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443149008745 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443149008746 active site 443149008747 substrate binding site [chemical binding]; other site 443149008748 metal binding site [ion binding]; metal-binding site 443149008749 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443149008750 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 443149008751 Transcription factor WhiB; Region: Whib; pfam02467 443149008752 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443149008753 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 443149008754 phosphate binding site [ion binding]; other site 443149008755 dimer interface [polypeptide binding]; other site 443149008756 substrate binding site [chemical binding]; other site 443149008757 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 443149008758 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 443149008759 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 443149008760 putative FMN binding site [chemical binding]; other site 443149008761 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 443149008762 Methyltransferase domain; Region: Methyltransf_26; pfam13659 443149008763 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443149008764 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443149008765 active site 443149008766 Substrate binding site; other site 443149008767 Mg++ binding site; other site 443149008768 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443149008769 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443149008770 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443149008771 Probable Catalytic site; other site 443149008772 metal-binding site 443149008773 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 443149008774 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443149008775 NADP binding site [chemical binding]; other site 443149008776 active site 443149008777 putative substrate binding site [chemical binding]; other site 443149008778 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149008779 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149008780 TIGR03089 family protein; Region: TIGR03089 443149008781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149008782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149008783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 443149008784 active site 443149008785 motif I; other site 443149008786 motif II; other site 443149008787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443149008788 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443149008789 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443149008790 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443149008791 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443149008792 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 443149008793 active site clefts [active] 443149008794 zinc binding site [ion binding]; other site 443149008795 dimer interface [polypeptide binding]; other site 443149008796 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149008797 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443149008798 FAD binding site [chemical binding]; other site 443149008799 homotetramer interface [polypeptide binding]; other site 443149008800 substrate binding pocket [chemical binding]; other site 443149008801 catalytic base [active] 443149008802 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 443149008803 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 443149008804 ATP-grasp domain; Region: ATP-grasp; pfam02222 443149008805 Predicted membrane protein [Function unknown]; Region: COG2246 443149008806 GtrA-like protein; Region: GtrA; pfam04138 443149008807 Bacterial PH domain; Region: DUF304; pfam03703 443149008808 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443149008809 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443149008810 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443149008811 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149008812 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149008813 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149008814 Maf-like protein; Region: Maf; pfam02545 443149008815 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443149008816 active site 443149008817 dimer interface [polypeptide binding]; other site 443149008818 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443149008819 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443149008820 active site residue [active] 443149008821 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443149008822 active site residue [active] 443149008823 Fe-S metabolism associated domain; Region: SufE; pfam02657 443149008824 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443149008825 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443149008826 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443149008827 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443149008828 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443149008829 carboxyltransferase (CT) interaction site; other site 443149008830 biotinylation site [posttranslational modification]; other site 443149008831 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443149008832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149008833 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443149008834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443149008835 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 443149008836 L-lysine aminotransferase; Provisional; Region: PRK08297 443149008837 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149008838 inhibitor-cofactor binding pocket; inhibition site 443149008839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149008840 catalytic residue [active] 443149008841 putative DNA binding site [nucleotide binding]; other site 443149008842 dimerization interface [polypeptide binding]; other site 443149008843 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443149008844 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 443149008845 putative Zn2+ binding site [ion binding]; other site 443149008846 AsnC family; Region: AsnC_trans_reg; pfam01037 443149008847 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 443149008848 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 443149008849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443149008850 tetrameric interface [polypeptide binding]; other site 443149008851 NAD binding site [chemical binding]; other site 443149008852 catalytic residues [active] 443149008853 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 443149008854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149008855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149008856 potential frameshift: common BLAST hit: gi|375297568|ref|YP_005101835.1| ATP-dependent helicase lhr 443149008857 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 443149008858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149008859 ATP binding site [chemical binding]; other site 443149008860 putative Mg++ binding site [ion binding]; other site 443149008861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149008862 nucleotide binding region [chemical binding]; other site 443149008863 ATP-binding site [chemical binding]; other site 443149008864 DEAD/H associated; Region: DEAD_assoc; pfam08494 443149008865 DEAD/H associated; Region: DEAD_assoc; pfam08494 443149008866 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443149008867 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443149008868 putative DNA binding site [nucleotide binding]; other site 443149008869 catalytic residue [active] 443149008870 putative H2TH interface [polypeptide binding]; other site 443149008871 putative catalytic residues [active] 443149008872 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443149008873 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 443149008874 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443149008875 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 443149008876 Sulfatase; Region: Sulfatase; pfam00884 443149008877 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 443149008878 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443149008879 probable active site [active] 443149008880 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443149008881 PhoU domain; Region: PhoU; pfam01895 443149008882 PhoU domain; Region: PhoU; pfam01895 443149008883 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443149008884 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443149008885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149008886 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443149008887 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443149008888 putative active site pocket [active] 443149008889 dimerization interface [polypeptide binding]; other site 443149008890 putative catalytic residue [active] 443149008891 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443149008892 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 443149008893 metal binding site [ion binding]; metal-binding site 443149008894 putative dimer interface [polypeptide binding]; other site 443149008895 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 443149008896 amidohydrolase; Region: amidohydrolases; TIGR01891 443149008897 metal binding site [ion binding]; metal-binding site 443149008898 purine nucleoside phosphorylase; Provisional; Region: PRK08202 443149008899 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 443149008900 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443149008901 active site 443149008902 substrate binding site [chemical binding]; other site 443149008903 metal binding site [ion binding]; metal-binding site 443149008904 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149008905 active site 443149008906 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443149008907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149008908 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443149008909 adenosine deaminase; Provisional; Region: PRK09358 443149008910 active site 443149008911 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443149008912 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443149008913 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443149008914 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 443149008915 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443149008916 active site 443149008917 catalytic motif [active] 443149008918 Zn binding site [ion binding]; other site 443149008919 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443149008920 putative Iron-sulfur protein interface [polypeptide binding]; other site 443149008921 putative proximal heme binding site [chemical binding]; other site 443149008922 putative SdhD-like interface [polypeptide binding]; other site 443149008923 putative distal heme binding site [chemical binding]; other site 443149008924 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443149008925 putative Iron-sulfur protein interface [polypeptide binding]; other site 443149008926 putative proximal heme binding site [chemical binding]; other site 443149008927 putative SdhC-like subunit interface [polypeptide binding]; other site 443149008928 putative distal heme binding site [chemical binding]; other site 443149008929 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443149008930 L-aspartate oxidase; Provisional; Region: PRK06175 443149008931 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443149008932 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443149008933 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 443149008934 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149008935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149008936 S-adenosylmethionine binding site [chemical binding]; other site 443149008937 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443149008938 MoaE interaction surface [polypeptide binding]; other site 443149008939 MoeB interaction surface [polypeptide binding]; other site 443149008940 thiocarboxylated glycine; other site 443149008941 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443149008942 MoaE homodimer interface [polypeptide binding]; other site 443149008943 MoaD interaction [polypeptide binding]; other site 443149008944 active site residues [active] 443149008945 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 443149008946 trimer interface [polypeptide binding]; other site 443149008947 dimer interface [polypeptide binding]; other site 443149008948 putative active site [active] 443149008949 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 443149008950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149008951 FeS/SAM binding site; other site 443149008952 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443149008953 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 443149008954 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 443149008955 DNA binding site [nucleotide binding] 443149008956 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443149008957 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443149008958 phosphopeptide binding site; other site 443149008959 putative transposase OrfB; Reviewed; Region: PHA02517 443149008960 HTH-like domain; Region: HTH_21; pfam13276 443149008961 Integrase core domain; Region: rve; pfam00665 443149008962 Integrase core domain; Region: rve_3; pfam13683 443149008963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149008964 Transposase; Region: HTH_Tnp_1; cl17663 443149008965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 443149008966 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149008967 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443149008968 hypothetical protein; Provisional; Region: PRK06541 443149008969 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443149008970 inhibitor-cofactor binding pocket; inhibition site 443149008971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149008972 catalytic residue [active] 443149008973 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443149008974 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443149008975 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 443149008976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149008977 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 443149008978 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 443149008979 active site 443149008980 dimer interface [polypeptide binding]; other site 443149008981 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149008982 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 443149008983 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443149008984 DNA binding residues [nucleotide binding] 443149008985 dimer interface [polypeptide binding]; other site 443149008986 metal binding site [ion binding]; metal-binding site 443149008987 inner membrane protein YhjD; Region: TIGR00766 443149008988 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443149008989 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443149008990 active site 443149008991 dimer interface [polypeptide binding]; other site 443149008992 KMSKS motif; other site 443149008993 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 443149008994 isocitrate dehydrogenase; Validated; Region: PRK08299 443149008995 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443149008996 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443149008997 homodimer interface [polypeptide binding]; other site 443149008998 substrate-cofactor binding pocket; other site 443149008999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009000 catalytic residue [active] 443149009001 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443149009002 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443149009003 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149009004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149009005 S-adenosylmethionine binding site [chemical binding]; other site 443149009006 PPE family; Region: PPE; pfam00823 443149009007 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009008 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009009 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009010 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009011 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009012 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009013 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009014 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009015 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009016 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009017 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009018 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009019 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009020 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009021 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009022 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009023 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009024 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009025 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009026 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009027 PE family; Region: PE; pfam00934 443149009028 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009029 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009030 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009032 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009033 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009034 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009035 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009036 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009037 PPE family; Region: PPE; pfam00823 443149009038 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009039 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009040 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149009041 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149009042 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009043 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009044 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009045 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009046 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009047 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009048 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009049 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009050 potential frameshift: common BLAST hit: gi|57117096|ref|YP_177964.1| PPE family protein 443149009051 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009052 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009053 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009054 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009055 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009056 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009057 PPE family; Region: PPE; pfam00823 443149009058 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009059 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009060 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009061 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009062 Berberine and berberine like; Region: BBE; pfam08031 443149009063 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149009064 Protein of unknown function (DUF732); Region: DUF732; pfam05305 443149009065 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443149009066 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443149009067 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443149009068 homodimer interface [polypeptide binding]; other site 443149009069 NADP binding site [chemical binding]; other site 443149009070 substrate binding site [chemical binding]; other site 443149009071 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443149009072 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443149009073 active site 443149009074 FMN binding site [chemical binding]; other site 443149009075 substrate binding site [chemical binding]; other site 443149009076 putative catalytic residue [active] 443149009077 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009078 phosphate binding site [ion binding]; other site 443149009079 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443149009080 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443149009081 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443149009082 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 443149009083 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 443149009084 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 443149009085 G1 box; other site 443149009086 GTP/Mg2+ binding site [chemical binding]; other site 443149009087 G2 box; other site 443149009088 Switch I region; other site 443149009089 G3 box; other site 443149009090 Switch II region; other site 443149009091 G4 box; other site 443149009092 G5 box; other site 443149009093 Protein of unknown function (DUF742); Region: DUF742; pfam05331 443149009094 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 443149009095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149009096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149009097 ATP binding site [chemical binding]; other site 443149009098 Mg2+ binding site [ion binding]; other site 443149009099 G-X-G motif; other site 443149009100 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 443149009101 PE family; Region: PE; pfam00934 443149009102 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443149009103 FMN binding site [chemical binding]; other site 443149009104 dimer interface [polypeptide binding]; other site 443149009105 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 443149009106 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443149009107 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 443149009108 active site 443149009109 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443149009110 generic binding surface II; other site 443149009111 generic binding surface I; other site 443149009112 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149009113 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149009114 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443149009115 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443149009116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149009117 active site 443149009118 motif I; other site 443149009119 motif II; other site 443149009120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149009121 substrate binding site [chemical binding]; other site 443149009122 oxyanion hole (OAH) forming residues; other site 443149009123 trimer interface [polypeptide binding]; other site 443149009124 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443149009125 Amidase; Region: Amidase; pfam01425 443149009126 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443149009127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149009128 motif II; other site 443149009129 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 443149009130 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 443149009131 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 443149009132 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 443149009133 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 443149009134 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443149009135 TPP-binding site; other site 443149009136 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443149009137 PYR/PP interface [polypeptide binding]; other site 443149009138 dimer interface [polypeptide binding]; other site 443149009139 TPP binding site [chemical binding]; other site 443149009140 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443149009141 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443149009142 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443149009143 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443149009144 aspartate-rich region 2; other site 443149009145 substrate-Mg2+ binding site; other site 443149009146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 443149009147 Transposase; Region: HTH_Tnp_1; cl17663 443149009148 HTH-like domain; Region: HTH_21; pfam13276 443149009149 Integrase core domain; Region: rve; pfam00665 443149009150 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443149009151 aspartate-rich region 1; other site 443149009152 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149009153 putative active site [active] 443149009154 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149009155 Transposase domain (DUF772); Region: DUF772; pfam05598 443149009156 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 443149009157 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 443149009158 PE family; Region: PE; pfam00934 443149009159 enoyl-CoA hydratase; Region: PLN02864 443149009160 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149009161 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443149009162 dimer interaction site [polypeptide binding]; other site 443149009163 substrate-binding tunnel; other site 443149009164 active site 443149009165 catalytic site [active] 443149009166 substrate binding site [chemical binding]; other site 443149009167 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149009168 short chain dehydrogenase; Provisional; Region: PRK07201 443149009169 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 443149009170 putative NAD(P) binding site [chemical binding]; other site 443149009171 active site 443149009172 putative substrate binding site [chemical binding]; other site 443149009173 classical (c) SDRs; Region: SDR_c; cd05233 443149009174 NAD(P) binding site [chemical binding]; other site 443149009175 active site 443149009176 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149009177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149009178 S-adenosylmethionine binding site [chemical binding]; other site 443149009179 DNA Polymerase Y-family; Region: PolY_like; cd03468 443149009180 DNA binding site [nucleotide binding] 443149009181 GMP synthase; Reviewed; Region: guaA; PRK00074 443149009182 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443149009183 AMP/PPi binding site [chemical binding]; other site 443149009184 candidate oxyanion hole; other site 443149009185 catalytic triad [active] 443149009186 potential glutamine specificity residues [chemical binding]; other site 443149009187 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443149009188 ATP Binding subdomain [chemical binding]; other site 443149009189 Ligand Binding sites [chemical binding]; other site 443149009190 Dimerization subdomain; other site 443149009191 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443149009192 active site lid residues [active] 443149009193 substrate binding pocket [chemical binding]; other site 443149009194 catalytic residues [active] 443149009195 substrate-Mg2+ binding site; other site 443149009196 aspartate-rich region 1; other site 443149009197 aspartate-rich region 2; other site 443149009198 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443149009199 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443149009200 substrate binding pocket [chemical binding]; other site 443149009201 chain length determination region; other site 443149009202 substrate-Mg2+ binding site; other site 443149009203 catalytic residues [active] 443149009204 aspartate-rich region 1; other site 443149009205 active site lid residues [active] 443149009206 aspartate-rich region 2; other site 443149009207 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149009208 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149009209 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443149009210 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443149009211 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443149009212 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443149009213 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443149009214 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443149009215 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 443149009216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149009217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149009218 catalytic residue [active] 443149009219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 443149009220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149009221 hypothetical protein; Provisional; Region: PRK07579 443149009222 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 443149009223 active site 443149009224 cosubstrate binding site; other site 443149009225 substrate binding site [chemical binding]; other site 443149009226 catalytic site [active] 443149009227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009229 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443149009230 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 443149009231 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 443149009232 putative active site [active] 443149009233 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443149009234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149009235 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443149009236 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443149009237 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009238 phosphate binding site [ion binding]; other site 443149009239 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443149009240 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443149009241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443149009242 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443149009243 active site 443149009244 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 443149009245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149009246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149009247 DNA binding residues [nucleotide binding] 443149009248 Transcription factor WhiB; Region: Whib; pfam02467 443149009249 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443149009250 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443149009251 ring oligomerisation interface [polypeptide binding]; other site 443149009252 ATP/Mg binding site [chemical binding]; other site 443149009253 stacking interactions; other site 443149009254 hinge regions; other site 443149009255 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443149009256 oligomerisation interface [polypeptide binding]; other site 443149009257 mobile loop; other site 443149009258 roof hairpin; other site 443149009259 UGMP family protein; Validated; Region: PRK09604 443149009260 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443149009261 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443149009262 Coenzyme A binding pocket [chemical binding]; other site 443149009263 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 443149009264 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 443149009265 alanine racemase; Reviewed; Region: alr; PRK00053 443149009266 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443149009267 active site 443149009268 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443149009269 dimer interface [polypeptide binding]; other site 443149009270 substrate binding site [chemical binding]; other site 443149009271 catalytic residues [active] 443149009272 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009273 PPE family; Region: PPE; pfam00823 443149009274 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 443149009275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149009276 Walker A motif; other site 443149009277 ATP binding site [chemical binding]; other site 443149009278 Walker B motif; other site 443149009279 arginine finger; other site 443149009280 putative transposase OrfB; Reviewed; Region: PHA02517 443149009281 HTH-like domain; Region: HTH_21; pfam13276 443149009282 Integrase core domain; Region: rve; pfam00665 443149009283 Integrase core domain; Region: rve_3; pfam13683 443149009284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149009285 Integrase core domain; Region: rve; pfam00665 443149009286 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009287 PPE family; Region: PPE; pfam00823 443149009288 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149009289 Integrase core domain; Region: rve; pfam00665 443149009290 Integrase core domain; Region: rve_3; pfam13683 443149009291 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149009292 MULE transposase domain; Region: MULE; pfam10551 443149009293 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 443149009294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009295 catalytic residue [active] 443149009296 Uncharacterized conserved protein [Function unknown]; Region: COG0062 443149009297 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443149009298 putative substrate binding site [chemical binding]; other site 443149009299 putative ATP binding site [chemical binding]; other site 443149009300 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443149009301 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443149009302 glutaminase active site [active] 443149009303 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443149009304 dimer interface [polypeptide binding]; other site 443149009305 active site 443149009306 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443149009307 dimer interface [polypeptide binding]; other site 443149009308 active site 443149009309 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443149009310 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 443149009311 active site 443149009312 metal binding site [ion binding]; metal-binding site 443149009313 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443149009314 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443149009315 23S rRNA interface [nucleotide binding]; other site 443149009316 L3 interface [polypeptide binding]; other site 443149009317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149009318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149009319 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 443149009320 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149009321 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009322 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149009323 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009324 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149009325 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149009326 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149009327 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149009328 active site 443149009329 catalytic residues [active] 443149009330 Protein of unknown function (DUF690); Region: DUF690; cl04939 443149009331 Cutinase; Region: Cutinase; pfam01083 443149009332 Cutinase; Region: Cutinase; pfam01083 443149009333 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443149009334 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443149009335 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 443149009336 active site 443149009337 dimerization interface 3.5A [polypeptide binding]; other site 443149009338 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443149009339 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443149009340 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443149009341 alphaNTD - beta interaction site [polypeptide binding]; other site 443149009342 alphaNTD homodimer interface [polypeptide binding]; other site 443149009343 alphaNTD - beta' interaction site [polypeptide binding]; other site 443149009344 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443149009345 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443149009346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443149009347 RNA binding surface [nucleotide binding]; other site 443149009348 30S ribosomal protein S11; Validated; Region: PRK05309 443149009349 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443149009350 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 443149009351 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 443149009352 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 443149009353 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443149009354 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443149009355 NAD binding site [chemical binding]; other site 443149009356 substrate binding site [chemical binding]; other site 443149009357 homodimer interface [polypeptide binding]; other site 443149009358 active site 443149009359 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 443149009360 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443149009361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443149009362 active site 443149009363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149009364 extended (e) SDRs; Region: SDR_e; cd08946 443149009365 NAD(P) binding site [chemical binding]; other site 443149009366 active site 443149009367 substrate binding site [chemical binding]; other site 443149009368 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443149009369 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 443149009370 active site 443149009371 catalytic residues [active] 443149009372 metal binding site [ion binding]; metal-binding site 443149009373 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 443149009374 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149009375 PYR/PP interface [polypeptide binding]; other site 443149009376 dimer interface [polypeptide binding]; other site 443149009377 TPP binding site [chemical binding]; other site 443149009378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443149009379 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443149009380 TPP-binding site [chemical binding]; other site 443149009381 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 443149009382 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 443149009383 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009384 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149009385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149009386 metabolite-proton symporter; Region: 2A0106; TIGR00883 443149009387 putative substrate translocation pore; other site 443149009388 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009389 PPE family; Region: PPE; pfam00823 443149009390 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149009391 patatin-related protein; Region: TIGR03607 443149009392 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149009393 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149009394 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443149009395 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149009396 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443149009397 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149009398 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443149009399 short chain dehydrogenase; Provisional; Region: PRK05875 443149009400 classical (c) SDRs; Region: SDR_c; cd05233 443149009401 NAD(P) binding site [chemical binding]; other site 443149009402 active site 443149009403 Predicted membrane protein [Function unknown]; Region: COG2259 443149009404 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443149009405 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443149009406 Predicted transcriptional regulators [Transcription]; Region: COG1695 443149009407 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443149009408 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 443149009409 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443149009410 active site 443149009411 homotetramer interface [polypeptide binding]; other site 443149009412 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009413 mce related protein; Region: MCE; pfam02470 443149009414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009415 mce related protein; Region: MCE; pfam02470 443149009416 mce related protein; Region: MCE; pfam02470 443149009417 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009418 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149009419 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009420 mce related protein; Region: MCE; pfam02470 443149009421 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009422 mce related protein; Region: MCE; pfam02470 443149009423 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443149009424 mce related protein; Region: MCE; pfam02470 443149009425 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443149009426 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149009427 Permease; Region: Permease; pfam02405 443149009428 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 443149009429 Permease; Region: Permease; pfam02405 443149009430 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 443149009431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149009432 NAD(P) binding site [chemical binding]; other site 443149009433 active site 443149009434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009435 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443149009436 FAD binding site [chemical binding]; other site 443149009437 substrate binding site [chemical binding]; other site 443149009438 catalytic base [active] 443149009439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009441 active site 443149009442 potential frameshift: common BLAST hit: gi|378773286|ref|YP_005173019.1| putative fatty-acid-CoA synthetase 443149009443 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009444 acyl-activating enzyme (AAE) consensus motif; other site 443149009445 potential frameshift: common BLAST hit: gi|378773286|ref|YP_005173019.1| putative fatty-acid-CoA synthetase 443149009446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009447 AMP binding site [chemical binding]; other site 443149009448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009449 CoA binding site [chemical binding]; other site 443149009450 PE family; Region: PE; pfam00934 443149009451 PE family; Region: PE; pfam00934 443149009452 hypothetical protein; Validated; Region: PRK07586 443149009453 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443149009454 PYR/PP interface [polypeptide binding]; other site 443149009455 dimer interface [polypeptide binding]; other site 443149009456 TPP binding site [chemical binding]; other site 443149009457 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 443149009458 TPP-binding site [chemical binding]; other site 443149009459 dimer interface [polypeptide binding]; other site 443149009460 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 443149009461 PE family; Region: PE; pfam00934 443149009462 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009463 CoA binding site [chemical binding]; other site 443149009464 PE family; Region: PE; pfam00934 443149009465 potential frameshift: common BLAST hit: gi|378773294|ref|YP_005173027.1| putative fatty-acid-CoA ligase 443149009466 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 443149009467 putative active site [active] 443149009468 putative CoA binding site [chemical binding]; other site 443149009469 putative AMP binding site [chemical binding]; other site 443149009470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009471 enoyl-CoA hydratase; Provisional; Region: PRK07799 443149009472 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149009473 substrate binding site [chemical binding]; other site 443149009474 oxyanion hole (OAH) forming residues; other site 443149009475 trimer interface [polypeptide binding]; other site 443149009476 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149009477 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149009478 Cytochrome P450; Region: p450; cl12078 443149009479 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 443149009480 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443149009481 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443149009482 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149009483 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149009484 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149009485 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149009486 lipid-transfer protein; Provisional; Region: PRK07937 443149009487 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149009488 active site 443149009489 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443149009490 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149009491 active site 443149009492 NHL repeat; Region: NHL; pfam01436 443149009493 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443149009494 NHL repeat; Region: NHL; pfam01436 443149009495 NHL repeat; Region: NHL; pfam01436 443149009496 NHL repeat; Region: NHL; pfam01436 443149009497 NHL repeat; Region: NHL; pfam01436 443149009498 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443149009499 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443149009500 trimer interface [polypeptide binding]; other site 443149009501 putative metal binding site [ion binding]; other site 443149009502 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443149009503 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443149009504 iron-sulfur cluster [ion binding]; other site 443149009505 [2Fe-2S] cluster binding site [ion binding]; other site 443149009506 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 443149009507 short chain dehydrogenase; Provisional; Region: PRK07890 443149009508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149009509 NAD(P) binding site [chemical binding]; other site 443149009510 active site 443149009511 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009512 PPE family; Region: PPE; pfam00823 443149009513 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 443149009514 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009515 PPE family; Region: PPE; pfam00823 443149009516 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009517 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 443149009518 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443149009519 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443149009520 active site 443149009521 catalytic residues [active] 443149009522 metal binding site [ion binding]; metal-binding site 443149009523 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443149009524 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443149009525 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149009526 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443149009527 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 443149009528 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 443149009529 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443149009530 enoyl-CoA hydratase; Region: PLN02864 443149009531 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443149009532 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443149009533 dimer interaction site [polypeptide binding]; other site 443149009534 substrate-binding tunnel; other site 443149009535 active site 443149009536 catalytic site [active] 443149009537 substrate binding site [chemical binding]; other site 443149009538 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009539 PPE family; Region: PPE; pfam00823 443149009540 PE-PPE domain; Region: PE-PPE; pfam08237 443149009541 lipid-transfer protein; Provisional; Region: PRK07855 443149009542 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443149009543 active site 443149009544 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 443149009545 putative active site [active] 443149009546 putative catalytic site [active] 443149009547 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443149009548 active site 443149009549 catalytic site [active] 443149009550 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443149009551 DUF35 OB-fold domain; Region: DUF35; pfam01796 443149009552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009554 active site 443149009555 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009556 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149009557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009558 active site 443149009559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149009560 Cytochrome P450; Region: p450; cl12078 443149009561 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 443149009562 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149009563 dimer interface [polypeptide binding]; other site 443149009564 active site 443149009565 Domain of unknown function (DUF385); Region: DUF385; pfam04075 443149009566 short chain dehydrogenase; Provisional; Region: PRK07791 443149009567 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443149009568 homodimer interface [polypeptide binding]; other site 443149009569 NAD binding site [chemical binding]; other site 443149009570 active site 443149009571 short chain dehydrogenase; Provisional; Region: PRK07856 443149009572 classical (c) SDRs; Region: SDR_c; cd05233 443149009573 NAD(P) binding site [chemical binding]; other site 443149009574 active site 443149009575 enoyl-CoA hydratase; Provisional; Region: PRK06495 443149009576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149009577 substrate binding site [chemical binding]; other site 443149009578 oxyanion hole (OAH) forming residues; other site 443149009579 trimer interface [polypeptide binding]; other site 443149009580 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 443149009581 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 443149009582 Nitronate monooxygenase; Region: NMO; pfam03060 443149009583 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443149009584 FMN binding site [chemical binding]; other site 443149009585 substrate binding site [chemical binding]; other site 443149009586 putative catalytic residue [active] 443149009587 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443149009588 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 443149009589 putative di-iron ligands [ion binding]; other site 443149009590 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443149009591 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443149009592 FAD binding pocket [chemical binding]; other site 443149009593 FAD binding motif [chemical binding]; other site 443149009594 phosphate binding motif [ion binding]; other site 443149009595 beta-alpha-beta structure motif; other site 443149009596 NAD(p) ribose binding residues [chemical binding]; other site 443149009597 NAD binding pocket [chemical binding]; other site 443149009598 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443149009599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149009600 catalytic loop [active] 443149009601 iron binding site [ion binding]; other site 443149009602 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443149009603 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149009604 putative active site [active] 443149009605 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 443149009606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443149009607 dimer interface [polypeptide binding]; other site 443149009608 active site 443149009609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009611 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009612 PPE family; Region: PPE; pfam00823 443149009613 short chain dehydrogenase; Provisional; Region: PRK07831 443149009614 classical (c) SDRs; Region: SDR_c; cd05233 443149009615 NAD(P) binding site [chemical binding]; other site 443149009616 active site 443149009617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009618 active site 443149009619 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443149009620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149009621 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 443149009622 acyl-activating enzyme (AAE) consensus motif; other site 443149009623 putative AMP binding site [chemical binding]; other site 443149009624 putative active site [active] 443149009625 putative CoA binding site [chemical binding]; other site 443149009626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009628 active site 443149009629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009630 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149009631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009633 active site 443149009634 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443149009635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009636 active site 443149009637 aspartate aminotransferase; Provisional; Region: PRK05764 443149009638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149009639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149009640 homodimer interface [polypeptide binding]; other site 443149009641 catalytic residue [active] 443149009642 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 443149009643 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443149009644 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443149009645 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 443149009646 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 443149009647 active site 443149009648 Fe binding site [ion binding]; other site 443149009649 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443149009650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009651 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 443149009652 Flavin binding site [chemical binding]; other site 443149009653 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443149009654 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443149009655 FAD binding pocket [chemical binding]; other site 443149009656 FAD binding motif [chemical binding]; other site 443149009657 phosphate binding motif [ion binding]; other site 443149009658 beta-alpha-beta structure motif; other site 443149009659 NAD(p) ribose binding residues [chemical binding]; other site 443149009660 NAD binding pocket [chemical binding]; other site 443149009661 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443149009662 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 443149009663 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443149009664 catalytic loop [active] 443149009665 iron binding site [ion binding]; other site 443149009666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443149009669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149009670 active site 443149009671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149009672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149009673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443149009674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443149009675 DNA binding site [nucleotide binding] 443149009676 domain linker motif; other site 443149009677 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 443149009678 putative dimerization interface [polypeptide binding]; other site 443149009679 putative ligand binding site [chemical binding]; other site 443149009680 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149009681 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149009682 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149009683 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443149009684 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443149009685 transmembrane helices; other site 443149009686 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443149009687 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443149009688 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 443149009689 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443149009690 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443149009691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443149009692 active site 443149009693 HIGH motif; other site 443149009694 nucleotide binding site [chemical binding]; other site 443149009695 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443149009696 KMSKS motif; other site 443149009697 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443149009698 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443149009699 homotrimer interaction site [polypeptide binding]; other site 443149009700 zinc binding site [ion binding]; other site 443149009701 CDP-binding sites; other site 443149009702 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443149009703 substrate binding site; other site 443149009704 dimer interface; other site 443149009705 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443149009706 DNA repair protein RadA; Provisional; Region: PRK11823 443149009707 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149009708 Walker A motif; other site 443149009709 ATP binding site [chemical binding]; other site 443149009710 Walker B motif; other site 443149009711 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443149009712 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 443149009713 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443149009714 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 443149009715 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443149009716 active site clefts [active] 443149009717 zinc binding site [ion binding]; other site 443149009718 dimer interface [polypeptide binding]; other site 443149009719 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149009720 endonuclease III; Region: ENDO3c; smart00478 443149009721 minor groove reading motif; other site 443149009722 helix-hairpin-helix signature motif; other site 443149009723 substrate binding pocket [chemical binding]; other site 443149009724 active site 443149009725 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443149009726 PE family; Region: PE; pfam00934 443149009727 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009728 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443149009729 catalytic site [active] 443149009730 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 443149009731 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 443149009732 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443149009733 Ami_2 domain; Region: Ami_2; smart00644 443149009734 amidase catalytic site [active] 443149009735 Zn binding residues [ion binding]; other site 443149009736 substrate binding site [chemical binding]; other site 443149009737 PE family; Region: PE; pfam00934 443149009738 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443149009739 Clp amino terminal domain; Region: Clp_N; pfam02861 443149009740 Clp amino terminal domain; Region: Clp_N; pfam02861 443149009741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149009742 Walker A motif; other site 443149009743 ATP binding site [chemical binding]; other site 443149009744 Walker B motif; other site 443149009745 arginine finger; other site 443149009746 UvrB/uvrC motif; Region: UVR; pfam02151 443149009747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149009748 Walker A motif; other site 443149009749 ATP binding site [chemical binding]; other site 443149009750 Walker B motif; other site 443149009751 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443149009752 Lsr2; Region: Lsr2; pfam11774 443149009753 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443149009754 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443149009755 dimer interface [polypeptide binding]; other site 443149009756 putative anticodon binding site; other site 443149009757 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443149009758 motif 1; other site 443149009759 dimer interface [polypeptide binding]; other site 443149009760 active site 443149009761 motif 2; other site 443149009762 motif 3; other site 443149009763 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443149009764 tetramerization interface [polypeptide binding]; other site 443149009765 active site 443149009766 pantothenate kinase; Reviewed; Region: PRK13318 443149009767 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443149009768 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443149009769 active site 443149009770 ATP-binding site [chemical binding]; other site 443149009771 pantoate-binding site; other site 443149009772 HXXH motif; other site 443149009773 Rossmann-like domain; Region: Rossmann-like; pfam10727 443149009774 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443149009775 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443149009776 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443149009777 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443149009778 catalytic center binding site [active] 443149009779 ATP binding site [chemical binding]; other site 443149009780 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 443149009781 homooctamer interface [polypeptide binding]; other site 443149009782 active site 443149009783 dihydropteroate synthase; Region: DHPS; TIGR01496 443149009784 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443149009785 substrate binding pocket [chemical binding]; other site 443149009786 dimer interface [polypeptide binding]; other site 443149009787 inhibitor binding site; inhibition site 443149009788 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 443149009789 homodecamer interface [polypeptide binding]; other site 443149009790 GTP cyclohydrolase I; Provisional; Region: PLN03044 443149009791 active site 443149009792 putative catalytic site residues [active] 443149009793 zinc binding site [ion binding]; other site 443149009794 GTP-CH-I/GFRP interaction surface; other site 443149009795 FtsH Extracellular; Region: FtsH_ext; pfam06480 443149009796 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443149009797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149009798 Walker A motif; other site 443149009799 ATP binding site [chemical binding]; other site 443149009800 Walker B motif; other site 443149009801 arginine finger; other site 443149009802 Peptidase family M41; Region: Peptidase_M41; pfam01434 443149009803 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 443149009804 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149009805 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009806 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443149009807 potential frameshift: common BLAST hit: gi|375297881|ref|YP_005102148.1| monooxygenase 443149009808 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443149009809 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149009810 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443149009811 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149009812 PPE family; Region: PPE; pfam00823 443149009813 Uncharacterized conserved protein [Function unknown]; Region: COG2968 443149009814 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 443149009815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443149009816 active site 443149009817 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443149009818 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443149009819 Ligand Binding Site [chemical binding]; other site 443149009820 Uncharacterized conserved protein [Function unknown]; Region: COG5282 443149009821 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443149009822 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 443149009823 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 443149009824 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443149009825 dimer interface [polypeptide binding]; other site 443149009826 substrate binding site [chemical binding]; other site 443149009827 metal binding sites [ion binding]; metal-binding site 443149009828 Protein of unknown function (DUF475); Region: DUF475; pfam04332 443149009829 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443149009830 Ligand binding site; other site 443149009831 Putative Catalytic site; other site 443149009832 DXD motif; other site 443149009833 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 443149009834 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 443149009835 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149009836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149009837 NAD(P) binding site [chemical binding]; other site 443149009838 active site 443149009839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149009840 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443149009841 Integrase core domain; Region: rve; pfam00665 443149009842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 443149009843 transposase; Provisional; Region: PRK06526 443149009844 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 443149009845 Walker B motif; other site 443149009846 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443149009847 MULE transposase domain; Region: MULE; pfam10551 443149009848 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 443149009849 Fic/DOC family; Region: Fic; cl00960 443149009850 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443149009851 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443149009852 potential frameshift: common BLAST hit: gi|378773419|ref|YP_005173152.1| putative transmembrane protein 443149009853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443149009854 dimerization interface [polypeptide binding]; other site 443149009855 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443149009856 cyclase homology domain; Region: CHD; cd07302 443149009857 nucleotidyl binding site; other site 443149009858 metal binding site [ion binding]; metal-binding site 443149009859 dimer interface [polypeptide binding]; other site 443149009860 potential frameshift: common BLAST hit: gi|375297911|ref|YP_005102178.1| DNA topoisomerase I topA 443149009861 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 443149009862 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149009863 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149009864 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443149009865 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 443149009866 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443149009867 active site 443149009868 interdomain interaction site; other site 443149009869 putative metal-binding site [ion binding]; other site 443149009870 nucleotide binding site [chemical binding]; other site 443149009871 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 443149009872 domain I; other site 443149009873 phosphate binding site [ion binding]; other site 443149009874 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443149009875 domain II; other site 443149009876 domain III; other site 443149009877 nucleotide binding site [chemical binding]; other site 443149009878 DNA binding groove [nucleotide binding] 443149009879 catalytic site [active] 443149009880 domain IV; other site 443149009881 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443149009882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443149009883 ATP binding site [chemical binding]; other site 443149009884 putative Mg++ binding site [ion binding]; other site 443149009885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443149009886 nucleotide binding region [chemical binding]; other site 443149009887 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 443149009888 PE family; Region: PE; pfam00934 443149009889 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443149009890 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443149009891 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 443149009892 Walker A motif; other site 443149009893 ATP binding site [chemical binding]; other site 443149009894 Walker B motif; other site 443149009895 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 443149009896 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443149009897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149009898 motif II; other site 443149009899 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443149009900 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149009901 Walker A/P-loop; other site 443149009902 ATP binding site [chemical binding]; other site 443149009903 Q-loop/lid; other site 443149009904 ABC transporter signature motif; other site 443149009905 Walker B; other site 443149009906 D-loop; other site 443149009907 H-loop/switch region; other site 443149009908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443149009909 Walker A/P-loop; other site 443149009910 ATP binding site [chemical binding]; other site 443149009911 Q-loop/lid; other site 443149009912 ABC transporter signature motif; other site 443149009913 Walker B; other site 443149009914 D-loop; other site 443149009915 H-loop/switch region; other site 443149009916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443149009917 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443149009918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149009919 ABC-ATPase subunit interface; other site 443149009920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443149009921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149009922 dimer interface [polypeptide binding]; other site 443149009923 conserved gate region; other site 443149009924 ABC-ATPase subunit interface; other site 443149009925 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 443149009926 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 443149009927 acetyl-CoA synthetase; Provisional; Region: PRK00174 443149009928 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 443149009929 active site 443149009930 CoA binding site [chemical binding]; other site 443149009931 acyl-activating enzyme (AAE) consensus motif; other site 443149009932 AMP binding site [chemical binding]; other site 443149009933 acetate binding site [chemical binding]; other site 443149009934 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 443149009935 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443149009936 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443149009937 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443149009938 putative active site [active] 443149009939 putative CoA binding site [chemical binding]; other site 443149009940 nudix motif; other site 443149009941 metal binding site [ion binding]; metal-binding site 443149009942 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443149009943 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149009944 catalytic residues [active] 443149009945 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 443149009946 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443149009947 minor groove reading motif; other site 443149009948 helix-hairpin-helix signature motif; other site 443149009949 substrate binding pocket [chemical binding]; other site 443149009950 active site 443149009951 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 443149009952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149009953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149009954 ligand binding site [chemical binding]; other site 443149009955 flexible hinge region; other site 443149009956 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443149009957 putative switch regulator; other site 443149009958 non-specific DNA interactions [nucleotide binding]; other site 443149009959 DNA binding site [nucleotide binding] 443149009960 sequence specific DNA binding site [nucleotide binding]; other site 443149009961 putative cAMP binding site [chemical binding]; other site 443149009962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149009963 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443149009964 homotrimer interaction site [polypeptide binding]; other site 443149009965 putative active site [active] 443149009966 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149009967 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149009968 P loop; other site 443149009969 Nucleotide binding site [chemical binding]; other site 443149009970 DTAP/Switch II; other site 443149009971 Switch I; other site 443149009972 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 443149009973 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149009974 DTAP/Switch II; other site 443149009975 Switch I; other site 443149009976 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443149009977 Transcription factor WhiB; Region: Whib; pfam02467 443149009978 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443149009979 Transglycosylase; Region: Transgly; pfam00912 443149009980 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443149009981 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443149009982 phosphodiesterase YaeI; Provisional; Region: PRK11340 443149009983 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443149009984 putative active site [active] 443149009985 putative metal binding site [ion binding]; other site 443149009986 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443149009987 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443149009988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149009989 catalytic residue [active] 443149009990 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443149009991 Cytochrome P450; Region: p450; cl12078 443149009992 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443149009993 anti sigma factor interaction site; other site 443149009994 regulatory phosphorylation site [posttranslational modification]; other site 443149009995 Uncharacterized conserved protein [Function unknown]; Region: COG1610 443149009996 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443149009997 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443149009998 MoxR-like ATPases [General function prediction only]; Region: COG0714 443149009999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010000 Walker A motif; other site 443149010001 ATP binding site [chemical binding]; other site 443149010002 Walker B motif; other site 443149010003 arginine finger; other site 443149010004 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443149010005 Protein of unknown function DUF58; Region: DUF58; pfam01882 443149010006 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 443149010007 Predicted membrane protein/domain [Function unknown]; Region: COG1714 443149010008 glycerol kinase; Provisional; Region: glpK; PRK00047 443149010009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443149010010 nucleotide binding site [chemical binding]; other site 443149010011 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 443149010012 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443149010013 Methyltransferase domain; Region: Methyltransf_23; pfam13489 443149010014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010015 S-adenosylmethionine binding site [chemical binding]; other site 443149010016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149010017 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149010018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010019 catalytic residue [active] 443149010020 Uncharacterized conserved protein [Function unknown]; Region: COG4301 443149010021 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 443149010022 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443149010023 putative dimer interface [polypeptide binding]; other site 443149010024 putative active site [active] 443149010025 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 443149010026 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 443149010027 PknH-like extracellular domain; Region: PknH_C; pfam14032 443149010028 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443149010029 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443149010030 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443149010031 aspartate kinase; Reviewed; Region: PRK06635 443149010032 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443149010033 putative nucleotide binding site [chemical binding]; other site 443149010034 putative catalytic residues [active] 443149010035 putative Mg ion binding site [ion binding]; other site 443149010036 putative aspartate binding site [chemical binding]; other site 443149010037 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443149010038 putative allosteric regulatory site; other site 443149010039 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443149010040 putative allosteric regulatory residue; other site 443149010041 2-isopropylmalate synthase; Validated; Region: PRK03739 443149010042 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443149010043 active site 443149010044 catalytic residues [active] 443149010045 metal binding site [ion binding]; metal-binding site 443149010046 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443149010047 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 443149010048 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443149010049 active site 443149010050 catalytic site [active] 443149010051 substrate binding site [chemical binding]; other site 443149010052 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 443149010053 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443149010054 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443149010055 catalytic triad [active] 443149010056 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443149010057 putative active site [active] 443149010058 recombination protein RecR; Reviewed; Region: recR; PRK00076 443149010059 RecR protein; Region: RecR; pfam02132 443149010060 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443149010061 putative active site [active] 443149010062 putative metal-binding site [ion binding]; other site 443149010063 tetramer interface [polypeptide binding]; other site 443149010064 hypothetical protein; Validated; Region: PRK00153 443149010065 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443149010066 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443149010067 active site 443149010068 metal binding site [ion binding]; metal-binding site 443149010069 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 443149010070 hydrophobic ligand binding site; other site 443149010071 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149010072 FAD binding domain; Region: FAD_binding_4; pfam01565 443149010073 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443149010074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010075 S-adenosylmethionine binding site [chemical binding]; other site 443149010076 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 443149010077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010078 Walker A motif; other site 443149010079 ATP binding site [chemical binding]; other site 443149010080 Walker B motif; other site 443149010081 arginine finger; other site 443149010082 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443149010083 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 443149010084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443149010085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010086 catalytic residue [active] 443149010087 Cutinase; Region: Cutinase; pfam01083 443149010088 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 443149010089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010090 NAD(P) binding site [chemical binding]; other site 443149010091 active site 443149010092 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443149010093 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 443149010094 putative NAD(P) binding site [chemical binding]; other site 443149010095 catalytic Zn binding site [ion binding]; other site 443149010096 Uncharacterized conserved protein [Function unknown]; Region: COG3349 443149010097 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 443149010098 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443149010099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443149010100 putative substrate translocation pore; other site 443149010101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443149010102 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443149010103 ligand binding site [chemical binding]; other site 443149010104 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443149010105 active site 443149010106 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 443149010107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443149010108 FeS/SAM binding site; other site 443149010109 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443149010110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010111 S-adenosylmethionine binding site [chemical binding]; other site 443149010112 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443149010113 nucleotide binding site [chemical binding]; other site 443149010114 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443149010115 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443149010116 active site 443149010117 DNA binding site [nucleotide binding] 443149010118 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443149010119 DNA binding site [nucleotide binding] 443149010120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 443149010121 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 443149010122 nudix motif; other site 443149010123 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149010124 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149010125 Uncharacterized conserved protein [Function unknown]; Region: COG1839 443149010126 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443149010127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149010128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149010129 Uncharacterized conserved protein [Function unknown]; Region: COG2966 443149010130 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 443149010131 Uncharacterized conserved protein [Function unknown]; Region: COG3610 443149010132 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010133 PPE family; Region: PPE; pfam00823 443149010134 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443149010135 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443149010136 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010137 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010138 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 443149010139 potential frameshift: common BLAST hit: gi|378773520|ref|YP_005173253.1| putative cation transporter P-type ATPase 443149010140 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 443149010141 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443149010142 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443149010143 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443149010144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443149010145 dimerization interface [polypeptide binding]; other site 443149010146 putative DNA binding site [nucleotide binding]; other site 443149010147 putative Zn2+ binding site [ion binding]; other site 443149010148 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443149010149 DNA binding domain, excisionase family; Region: excise; TIGR01764 443149010150 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443149010151 nucleoside/Zn binding site; other site 443149010152 dimer interface [polypeptide binding]; other site 443149010153 catalytic motif [active] 443149010154 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 443149010155 prephenate dehydrogenase; Validated; Region: PRK06545 443149010156 prephenate dehydrogenase; Validated; Region: PRK08507 443149010157 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 443149010158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443149010159 ABC-ATPase subunit interface; other site 443149010160 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443149010161 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443149010162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 443149010163 Walker A/P-loop; other site 443149010164 ATP binding site [chemical binding]; other site 443149010165 Q-loop/lid; other site 443149010166 ABC transporter signature motif; other site 443149010167 Walker B; other site 443149010168 D-loop; other site 443149010169 H-loop/switch region; other site 443149010170 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 443149010171 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443149010172 putative active site [active] 443149010173 putative substrate binding site [chemical binding]; other site 443149010174 ATP binding site [chemical binding]; other site 443149010175 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 443149010176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443149010177 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 443149010178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443149010179 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 443149010180 dimerization interface [polypeptide binding]; other site 443149010181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443149010182 dimer interface [polypeptide binding]; other site 443149010183 phosphorylation site [posttranslational modification] 443149010184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443149010185 ATP binding site [chemical binding]; other site 443149010186 Mg2+ binding site [ion binding]; other site 443149010187 G-X-G motif; other site 443149010188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443149010189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443149010190 active site 443149010191 phosphorylation site [posttranslational modification] 443149010192 intermolecular recognition site; other site 443149010193 dimerization interface [polypeptide binding]; other site 443149010194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443149010195 DNA binding site [nucleotide binding] 443149010196 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 443149010197 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149010198 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149010199 SnoaL-like domain; Region: SnoaL_2; pfam12680 443149010200 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 443149010201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443149010202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443149010203 homodimer interface [polypeptide binding]; other site 443149010204 catalytic residue [active] 443149010205 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443149010206 TIGR03086 family protein; Region: TIGR03086 443149010207 enoyl-CoA hydratase; Provisional; Region: PRK06142 443149010208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443149010209 substrate binding site [chemical binding]; other site 443149010210 oxyanion hole (OAH) forming residues; other site 443149010211 trimer interface [polypeptide binding]; other site 443149010212 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443149010213 Beta-lactamase; Region: Beta-lactamase; pfam00144 443149010214 potential protein location (hypothetical protein CCDC5079_3504 [Mycobacterium tuberculosis CCDC5079]) that overlaps RNA (tRNA-S) 443149010215 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443149010216 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443149010217 NAD(P) binding site [chemical binding]; other site 443149010218 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443149010219 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 443149010220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443149010221 catalytic residue [active] 443149010222 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 443149010223 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443149010224 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443149010225 Walker A/P-loop; other site 443149010226 ATP binding site [chemical binding]; other site 443149010227 Q-loop/lid; other site 443149010228 ABC transporter signature motif; other site 443149010229 Walker B; other site 443149010230 D-loop; other site 443149010231 H-loop/switch region; other site 443149010232 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149010233 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010234 active site 443149010235 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443149010236 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443149010237 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443149010238 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 443149010239 NAD binding site [chemical binding]; other site 443149010240 substrate binding site [chemical binding]; other site 443149010241 active site 443149010242 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443149010243 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010244 active site 443149010245 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443149010246 Peptidase family M23; Region: Peptidase_M23; pfam01551 443149010247 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 443149010248 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 443149010249 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 443149010250 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443149010251 Predicted membrane protein [Function unknown]; Region: COG2246 443149010252 GtrA-like protein; Region: GtrA; pfam04138 443149010253 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443149010254 FAD binding domain; Region: FAD_binding_4; pfam01565 443149010255 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443149010256 short chain dehydrogenase; Provisional; Region: PRK07904 443149010257 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443149010258 NAD(P) binding site [chemical binding]; other site 443149010259 active site 443149010260 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 443149010261 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 443149010262 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010263 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010264 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443149010265 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 443149010266 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 443149010267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443149010268 FAD binding site [chemical binding]; other site 443149010269 substrate binding site [chemical binding]; other site 443149010270 catalytic residues [active] 443149010271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 443149010272 Transposase; Region: DDE_Tnp_ISL3; pfam01610 443149010273 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443149010274 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443149010275 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443149010276 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010277 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149010278 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149010279 active site 443149010280 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443149010281 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149010282 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010283 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443149010284 potential frameshift: common BLAST hit: gi|375298071|ref|YP_005102339.1| fatty-acid-CoA ligase fadD32 443149010285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149010286 AMP binding site [chemical binding]; other site 443149010287 active site 443149010288 CoA binding site [chemical binding]; other site 443149010289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443149010290 Cutinase; Region: Cutinase; pfam01083 443149010291 Predicted esterase [General function prediction only]; Region: COG0627 443149010292 Putative esterase; Region: Esterase; pfam00756 443149010293 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 443149010294 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443149010295 active site 443149010296 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443149010297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443149010298 active site 443149010299 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443149010300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010301 UDP-galactopyranose mutase; Region: GLF; pfam03275 443149010302 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443149010303 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443149010304 amidase catalytic site [active] 443149010305 Zn binding residues [ion binding]; other site 443149010306 substrate binding site [chemical binding]; other site 443149010307 LGFP repeat; Region: LGFP; pfam08310 443149010308 PE family; Region: PE; pfam00934 443149010309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443149010310 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443149010311 active site 443149010312 motif I; other site 443149010313 motif II; other site 443149010314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443149010315 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010317 putative acyl-acceptor binding pocket; other site 443149010318 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010319 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010320 putative acyl-acceptor binding pocket; other site 443149010321 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443149010322 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443149010323 putative acyl-acceptor binding pocket; other site 443149010324 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 443149010325 Phosphotransferase enzyme family; Region: APH; pfam01636 443149010326 active site 443149010327 ATP binding site [chemical binding]; other site 443149010328 antibiotic binding site [chemical binding]; other site 443149010329 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443149010330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443149010331 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443149010332 iron-sulfur cluster [ion binding]; other site 443149010333 [2Fe-2S] cluster binding site [ion binding]; other site 443149010334 Condensation domain; Region: Condensation; pfam00668 443149010335 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443149010336 PE-PPE domain; Region: PE-PPE; pfam08237 443149010337 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443149010338 peptide synthase; Provisional; Region: PRK12316 443149010339 potential frameshift: common BLAST hit: gi|378773606|ref|YP_005173339.1| polyketide synthase 443149010340 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 443149010341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443149010342 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 443149010343 Enoylreductase; Region: PKS_ER; smart00829 443149010344 NAD(P) binding site [chemical binding]; other site 443149010345 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 443149010346 KR domain; Region: KR; pfam08659 443149010347 putative NADP binding site [chemical binding]; other site 443149010348 active site 443149010349 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443149010350 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 443149010351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443149010352 active site 443149010353 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 443149010354 acyl-CoA synthetase; Validated; Region: PRK05850 443149010355 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 443149010356 acyl-activating enzyme (AAE) consensus motif; other site 443149010357 active site 443149010358 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443149010359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443149010360 Probable transposase; Region: OrfB_IS605; pfam01385 443149010361 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443149010362 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443149010363 catalytic residues [active] 443149010364 catalytic nucleophile [active] 443149010365 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443149010366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010367 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443149010368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010369 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 443149010370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443149010371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443149010372 Cupin domain; Region: Cupin_2; cl17218 443149010373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443149010374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443149010375 seryl-tRNA synthetase; Provisional; Region: PRK05431 443149010376 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443149010377 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443149010378 dimer interface [polypeptide binding]; other site 443149010379 active site 443149010380 motif 1; other site 443149010381 motif 2; other site 443149010382 motif 3; other site 443149010383 Septum formation; Region: Septum_form; pfam13845 443149010384 Septum formation; Region: Septum_form; pfam13845 443149010385 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 443149010386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443149010387 catalytic core [active] 443149010388 prephenate dehydratase; Provisional; Region: PRK11898 443149010389 Prephenate dehydratase; Region: PDT; pfam00800 443149010390 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443149010391 putative L-Phe binding site [chemical binding]; other site 443149010392 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443149010393 Ferritin-like domain; Region: Ferritin; pfam00210 443149010394 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443149010395 ferroxidase diiron center [ion binding]; other site 443149010396 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 443149010397 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443149010398 putative active site [active] 443149010399 catalytic site [active] 443149010400 putative metal binding site [ion binding]; other site 443149010401 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 443149010402 Transposase; Region: DEDD_Tnp_IS110; pfam01548 443149010403 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443149010404 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443149010405 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443149010406 Predicted membrane protein [Function unknown]; Region: COG2119 443149010407 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443149010408 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 443149010409 Fimbrial protein; Region: Fimbrial; cl01416 443149010410 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 443149010411 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443149010412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443149010413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443149010414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443149010415 hypothetical protein; Provisional; Region: PRK07945 443149010416 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 443149010417 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 443149010418 active site 443149010419 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443149010420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443149010421 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 443149010422 domain_subunit interface; other site 443149010423 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 443149010424 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443149010425 active site 443149010426 dimer interface [polypeptide binding]; other site 443149010427 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443149010428 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 443149010429 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443149010430 active site 443149010431 FMN binding site [chemical binding]; other site 443149010432 substrate binding site [chemical binding]; other site 443149010433 3Fe-4S cluster binding site [ion binding]; other site 443149010434 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 443149010435 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010436 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 443149010437 EspG family; Region: ESX-1_EspG; pfam14011 443149010438 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149010439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010440 Walker A motif; other site 443149010441 ATP binding site [chemical binding]; other site 443149010442 Walker B motif; other site 443149010443 arginine finger; other site 443149010444 potential frameshift: common BLAST hit: gi|378773647|ref|YP_005173380.1| ESX-1 secretion system protein EccB1 443149010445 Protein of unknown function (DUF690); Region: DUF690; cl04939 443149010446 potential frameshift: common BLAST hit: gi|378773647|ref|YP_005173380.1| ESX-1 secretion system protein EccB1 443149010447 Protein of unknown function (DUF690); Region: DUF690; cl04939 443149010448 Protein of unknown function (DUF690); Region: DUF690; cl04939 443149010449 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149010450 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010451 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149010452 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010453 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010454 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 443149010455 PPE family; Region: PPE; pfam00823 443149010456 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443149010457 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010458 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149010459 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 443149010460 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149010461 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010462 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443149010463 active site 443149010464 catalytic residues [active] 443149010465 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 443149010466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443149010467 Walker A motif; other site 443149010468 ATP binding site [chemical binding]; other site 443149010469 Walker B motif; other site 443149010470 arginine finger; other site 443149010471 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 443149010472 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010473 catalytic residues [active] 443149010474 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443149010475 active site 443149010476 catalytic residues [active] 443149010477 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 443149010478 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443149010479 EspG family; Region: ESX-1_EspG; pfam14011 443149010480 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 443149010481 PPE family; Region: PPE; pfam00823 443149010482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010483 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443149010484 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010485 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443149010486 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443149010487 Protein of unknown function (DUF690); Region: DUF690; pfam05108 443149010488 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443149010489 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443149010490 catalytic residue [active] 443149010491 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 443149010492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 443149010493 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443149010494 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443149010495 active site 443149010496 NTP binding site [chemical binding]; other site 443149010497 metal binding triad [ion binding]; metal-binding site 443149010498 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443149010499 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443149010500 Zn2+ binding site [ion binding]; other site 443149010501 Mg2+ binding site [ion binding]; other site 443149010502 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 443149010503 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443149010504 active site 443149010505 Ap6A binding site [chemical binding]; other site 443149010506 nudix motif; other site 443149010507 metal binding site [ion binding]; metal-binding site 443149010508 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 443149010509 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443149010510 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 443149010511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443149010512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443149010513 DNA binding residues [nucleotide binding] 443149010514 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443149010515 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443149010516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443149010517 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443149010518 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443149010519 catalytic residues [active] 443149010520 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 443149010521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443149010522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443149010523 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443149010524 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443149010525 active site 443149010526 metal binding site [ion binding]; metal-binding site 443149010527 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443149010528 ParB-like nuclease domain; Region: ParB; smart00470 443149010529 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443149010530 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149010531 P-loop; other site 443149010532 Magnesium ion binding site [ion binding]; other site 443149010533 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443149010534 Magnesium ion binding site [ion binding]; other site 443149010535 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 443149010536 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443149010537 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 443149010538 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443149010539 G-X-X-G motif; other site 443149010540 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443149010541 RxxxH motif; other site 443149010542 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449