-- dump date 20140619_153533 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710686000001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686000002 catalytic tetrad [active] 710686000003 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710686000004 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686000005 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710686000006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710686000007 active site 710686000008 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 710686000009 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 710686000010 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710686000011 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 710686000012 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 710686000013 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 710686000014 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 710686000015 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710686000016 putative catalytic site [active] 710686000017 putative metal binding site [ion binding]; other site 710686000018 putative phosphate binding site [ion binding]; other site 710686000019 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 710686000020 Secretory lipase; Region: LIP; pfam03583 710686000021 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710686000022 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686000023 active site 710686000024 catalytic triad [active] 710686000025 oxyanion hole [active] 710686000026 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 710686000027 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710686000028 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710686000029 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 710686000030 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 710686000031 active site 710686000032 Substrate binding site; other site 710686000033 Mg++ binding site; other site 710686000034 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710686000035 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686000036 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710686000037 Ligand binding site; other site 710686000038 Putative Catalytic site; other site 710686000039 DXD motif; other site 710686000040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686000041 active site 710686000042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686000043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686000044 active site 710686000045 ATP binding site [chemical binding]; other site 710686000046 substrate binding site [chemical binding]; other site 710686000047 activation loop (A-loop); other site 710686000048 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 710686000049 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686000050 intersubunit interface [polypeptide binding]; other site 710686000051 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686000052 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686000053 phosphopeptide binding site; other site 710686000054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000055 non-specific DNA binding site [nucleotide binding]; other site 710686000056 salt bridge; other site 710686000057 sequence-specific DNA binding site [nucleotide binding]; other site 710686000058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 710686000059 CHAT domain; Region: CHAT; cl17868 710686000060 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710686000061 Peptidase family M23; Region: Peptidase_M23; pfam01551 710686000062 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710686000063 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 710686000064 substrate binding site [chemical binding]; other site 710686000065 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 710686000066 substrate binding site [chemical binding]; other site 710686000067 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710686000068 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 710686000069 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 710686000070 putative sugar binding sites [chemical binding]; other site 710686000071 Q-X-W motif; other site 710686000072 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 710686000073 PLD-like domain; Region: PLDc_2; pfam13091 710686000074 putative active site [active] 710686000075 catalytic site [active] 710686000076 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 710686000077 PLD-like domain; Region: PLDc_2; pfam13091 710686000078 putative active site [active] 710686000079 catalytic site [active] 710686000080 aminoglycoside resistance protein; Provisional; Region: PRK13746 710686000081 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 710686000082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686000083 active site 710686000084 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710686000085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710686000086 active site 710686000087 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 710686000088 Kelch domain; Region: Kelch; smart00612 710686000089 Kelch motif; Region: Kelch_6; pfam13964 710686000090 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710686000091 Kelch domain; Region: Kelch; smart00612 710686000092 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710686000093 Kelch domain; Region: Kelch; smart00612 710686000094 CopC domain; Region: CopC; cl01012 710686000095 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 710686000096 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 710686000097 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 710686000098 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 710686000099 PAAR motif; Region: PAAR_motif; pfam05488 710686000100 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 710686000101 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 710686000102 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 710686000103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000104 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710686000105 Walker A motif; other site 710686000106 ATP binding site [chemical binding]; other site 710686000107 Walker B motif; other site 710686000108 arginine finger; other site 710686000109 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 710686000110 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 710686000111 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 710686000112 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 710686000113 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 710686000114 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710686000115 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710686000116 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686000117 TIR domain; Region: TIR_2; pfam13676 710686000118 TIR domain; Region: TIR_2; cl17458 710686000119 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000120 structural tetrad; other site 710686000121 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686000122 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000123 structural tetrad; other site 710686000124 Caspase domain; Region: Peptidase_C14; pfam00656 710686000125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710686000126 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686000127 WD domain, G-beta repeat; Region: WD40; pfam00400 710686000128 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000129 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686000130 structural tetrad; other site 710686000131 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000132 structural tetrad; other site 710686000133 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710686000134 TIR domain; Region: TIR_2; pfam13676 710686000135 AAA ATPase domain; Region: AAA_16; pfam13191 710686000136 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686000137 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000138 structural tetrad; other site 710686000139 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686000140 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686000141 structural tetrad; other site 710686000142 WD domain, G-beta repeat; Region: WD40; pfam00400 710686000143 WD domain, G-beta repeat; Region: WD40; pfam00400 710686000144 TIR domain; Region: TIR_2; pfam13676 710686000145 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 710686000146 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686000147 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686000148 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686000149 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710686000150 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 710686000151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686000152 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686000153 NAD(P) binding site [chemical binding]; other site 710686000154 active site 710686000155 putative acyltransferase; Provisional; Region: PRK05790 710686000156 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686000157 dimer interface [polypeptide binding]; other site 710686000158 active site 710686000159 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 710686000160 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686000161 cyclase homology domain; Region: CHD; cd07302 710686000162 nucleotidyl binding site; other site 710686000163 metal binding site [ion binding]; metal-binding site 710686000164 dimer interface [polypeptide binding]; other site 710686000165 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686000166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686000167 active site 710686000168 ATP binding site [chemical binding]; other site 710686000169 substrate binding site [chemical binding]; other site 710686000170 activation loop (A-loop); other site 710686000171 Predicted ATPase [General function prediction only]; Region: COG3903 710686000172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710686000173 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686000174 Cytochrome P450; Region: p450; cl12078 710686000175 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710686000176 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686000177 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686000178 iron-sulfur cluster [ion binding]; other site 710686000179 [2Fe-2S] cluster binding site [ion binding]; other site 710686000180 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686000181 hydrophobic ligand binding site; other site 710686000182 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686000183 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 710686000184 FMN-binding pocket [chemical binding]; other site 710686000185 flavin binding motif; other site 710686000186 phosphate binding motif [ion binding]; other site 710686000187 beta-alpha-beta structure motif; other site 710686000188 NAD binding pocket [chemical binding]; other site 710686000189 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686000190 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710686000191 catalytic loop [active] 710686000192 iron binding site [ion binding]; other site 710686000193 Putative esterase; Region: Esterase; pfam00756 710686000194 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710686000195 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686000196 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686000197 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000198 mce related protein; Region: MCE; pfam02470 710686000199 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000200 mce related protein; Region: MCE; pfam02470 710686000201 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686000202 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000203 mce related protein; Region: MCE; pfam02470 710686000204 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000205 mce related protein; Region: MCE; pfam02470 710686000206 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686000207 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000208 mce related protein; Region: MCE; pfam02470 710686000209 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686000210 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686000211 mce related protein; Region: MCE; pfam02470 710686000212 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686000213 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686000214 Permease; Region: Permease; pfam02405 710686000215 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686000216 Permease; Region: Permease; pfam02405 710686000217 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686000218 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686000219 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 710686000220 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686000221 NAD binding site [chemical binding]; other site 710686000222 catalytic Zn binding site [ion binding]; other site 710686000223 substrate binding site [chemical binding]; other site 710686000224 structural Zn binding site [ion binding]; other site 710686000225 Predicted acyl esterases [General function prediction only]; Region: COG2936 710686000226 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686000227 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 710686000228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686000229 classical (c) SDRs; Region: SDR_c; cd05233 710686000230 NAD(P) binding site [chemical binding]; other site 710686000231 active site 710686000232 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686000233 hypothetical protein; Provisional; Region: PRK08244 710686000234 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686000235 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710686000236 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 710686000237 active site 710686000238 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710686000239 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 710686000240 active site 710686000241 dimer interface [polypeptide binding]; other site 710686000242 metal binding site [ion binding]; metal-binding site 710686000243 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710686000244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686000245 acyl-activating enzyme (AAE) consensus motif; other site 710686000246 AMP binding site [chemical binding]; other site 710686000247 active site 710686000248 CoA binding site [chemical binding]; other site 710686000249 Helix-turn-helix domain; Region: HTH_18; pfam12833 710686000250 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686000251 formyl-coenzyme A transferase; Provisional; Region: PRK05398 710686000252 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686000253 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686000254 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686000255 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 710686000256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686000257 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710686000258 dimerization interface [polypeptide binding]; other site 710686000259 substrate binding pocket [chemical binding]; other site 710686000260 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686000261 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710686000262 dimer interface [polypeptide binding]; other site 710686000263 active site 710686000264 Coenzyme A transferase; Region: CoA_trans; cl17247 710686000265 Coenzyme A transferase; Region: CoA_trans; cl17247 710686000266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686000267 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686000268 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686000269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686000270 Cytochrome P450; Region: p450; cl12078 710686000271 Predicted ATPase [General function prediction only]; Region: COG3903 710686000272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686000273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686000274 DNA binding residues [nucleotide binding] 710686000275 dimerization interface [polypeptide binding]; other site 710686000276 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 710686000277 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 710686000278 putative active site [active] 710686000279 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 710686000280 hypothetical protein; Provisional; Region: PRK02268 710686000281 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 710686000282 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686000283 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686000284 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 710686000285 putative active site [active] 710686000286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710686000287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710686000288 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710686000289 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710686000290 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 710686000291 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686000292 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710686000293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686000294 DNA binding residues [nucleotide binding] 710686000295 dimerization interface [polypeptide binding]; other site 710686000296 Putative zinc-finger; Region: zf-HC2; pfam13490 710686000297 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686000298 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710686000299 NodB motif; other site 710686000300 active site 710686000301 catalytic site [active] 710686000302 metal binding site [ion binding]; metal-binding site 710686000303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000305 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710686000306 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686000307 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 710686000308 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 710686000309 oligomeric interface; other site 710686000310 putative active site [active] 710686000311 homodimer interface [polypeptide binding]; other site 710686000312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686000314 dimer interface [polypeptide binding]; other site 710686000315 phosphorylation site [posttranslational modification] 710686000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686000317 ATP binding site [chemical binding]; other site 710686000318 Mg2+ binding site [ion binding]; other site 710686000319 G-X-G motif; other site 710686000320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686000321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686000322 active site 710686000323 phosphorylation site [posttranslational modification] 710686000324 intermolecular recognition site; other site 710686000325 dimerization interface [polypeptide binding]; other site 710686000326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686000327 DNA binding site [nucleotide binding] 710686000328 ApbE family; Region: ApbE; pfam02424 710686000329 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 710686000330 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710686000331 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686000332 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686000333 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686000334 dinuclear metal binding motif [ion binding]; other site 710686000335 CCC1-related family of proteins; Region: CCC1_like; cl00278 710686000336 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710686000337 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 710686000338 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710686000339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710686000340 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710686000341 active site 710686000342 catalytic residues [active] 710686000343 DNA binding site [nucleotide binding] 710686000344 Int/Topo IB signature motif; other site 710686000345 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710686000346 active site 710686000347 catalytic residues [active] 710686000348 DNA binding site [nucleotide binding] 710686000349 Int/Topo IB signature motif; other site 710686000350 Helix-turn-helix; Region: HTH_3; pfam01381 710686000351 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 710686000352 Superfamily II helicase [General function prediction only]; Region: COG1204 710686000353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686000354 ATP binding site [chemical binding]; other site 710686000355 putative Mg++ binding site [ion binding]; other site 710686000356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686000357 nucleotide binding region [chemical binding]; other site 710686000358 ATP-binding site [chemical binding]; other site 710686000359 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 710686000360 Catalytic site; other site 710686000361 ParB-like nuclease domain; Region: ParBc; pfam02195 710686000362 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686000363 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000364 P-loop; other site 710686000365 Magnesium ion binding site [ion binding]; other site 710686000366 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 710686000367 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686000368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000369 P-loop; other site 710686000370 Magnesium ion binding site [ion binding]; other site 710686000371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000372 Magnesium ion binding site [ion binding]; other site 710686000373 Transcription factor WhiB; Region: Whib; pfam02467 710686000374 Helix-turn-helix domain; Region: HTH_36; pfam13730 710686000375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 710686000376 active site 710686000377 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710686000378 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710686000379 TrwC relaxase; Region: TrwC; pfam08751 710686000380 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710686000381 AAA domain; Region: AAA_30; pfam13604 710686000382 Family description; Region: UvrD_C_2; pfam13538 710686000383 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710686000384 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710686000385 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710686000386 catalytic residues [active] 710686000387 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 710686000388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 710686000389 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 710686000390 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 710686000391 Predicted esterase [General function prediction only]; Region: COG0627 710686000392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710686000393 non-specific DNA binding site [nucleotide binding]; other site 710686000394 salt bridge; other site 710686000395 sequence-specific DNA binding site [nucleotide binding]; other site 710686000396 Double zinc ribbon; Region: DZR; pfam12773 710686000397 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710686000398 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686000399 cyclase homology domain; Region: CHD; cd07302 710686000400 nucleotidyl binding site; other site 710686000401 metal binding site [ion binding]; metal-binding site 710686000402 dimer interface [polypeptide binding]; other site 710686000403 Predicted ATPase [General function prediction only]; Region: COG3899 710686000404 AAA ATPase domain; Region: AAA_16; pfam13191 710686000405 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686000406 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710686000407 NodB motif; other site 710686000408 active site 710686000409 catalytic site [active] 710686000410 metal binding site [ion binding]; metal-binding site 710686000411 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 710686000412 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 710686000413 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686000414 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686000415 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710686000416 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710686000417 PPE family; Region: PPE; pfam00823 710686000418 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 710686000419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 710686000420 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 710686000421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686000422 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710686000423 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000424 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710686000425 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000426 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710686000428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686000429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686000430 DNA binding residues [nucleotide binding] 710686000431 dimerization interface [polypeptide binding]; other site 710686000432 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 710686000433 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 710686000434 UbiA prenyltransferase family; Region: UbiA; pfam01040 710686000435 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 710686000436 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 710686000437 active site 710686000438 metal binding site [ion binding]; metal-binding site 710686000439 nudix motif; other site 710686000440 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710686000441 Putative zinc-finger; Region: zf-HC2; pfam13490 710686000442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000444 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710686000445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686000446 DNA binding residues [nucleotide binding] 710686000447 PPE family; Region: PPE; pfam00823 710686000448 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710686000449 EspG family; Region: ESX-1_EspG; pfam14011 710686000450 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710686000451 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710686000452 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710686000453 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710686000454 catalytic residues [active] 710686000455 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710686000456 active site 710686000457 catalytic residues [active] 710686000458 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710686000459 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686000460 active site 710686000461 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686000462 classical (c) SDRs; Region: SDR_c; cd05233 710686000463 NAD(P) binding site [chemical binding]; other site 710686000464 active site 710686000465 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686000466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686000467 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686000468 short chain dehydrogenase; Provisional; Region: PRK06500 710686000469 classical (c) SDRs; Region: SDR_c; cd05233 710686000470 NAD(P) binding site [chemical binding]; other site 710686000471 active site 710686000472 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686000473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000475 haloalkane dehalogenase; Provisional; Region: PRK03592 710686000476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686000477 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686000478 active site 710686000479 catalytic tetrad [active] 710686000480 Uncharacterized conserved protein [Function unknown]; Region: COG1359 710686000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686000482 short chain dehydrogenase; Provisional; Region: PRK06500 710686000483 classical (c) SDRs; Region: SDR_c; cd05233 710686000484 NAD(P) binding site [chemical binding]; other site 710686000485 active site 710686000486 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686000487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686000488 Putative serine esterase (DUF676); Region: DUF676; pfam05057 710686000489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000490 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686000491 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686000492 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686000493 putative hydrophobic ligand binding site [chemical binding]; other site 710686000494 protein interface [polypeptide binding]; other site 710686000495 gate; other site 710686000496 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 710686000497 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686000498 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710686000499 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710686000500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000502 short chain dehydrogenase; Provisional; Region: PRK06197 710686000503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686000504 NAD(P) binding site [chemical binding]; other site 710686000505 active site 710686000506 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710686000507 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710686000508 active site residue [active] 710686000509 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710686000510 active site residue [active] 710686000511 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686000512 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 710686000513 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 710686000514 active site 710686000515 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686000516 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686000517 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686000518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686000519 Cytochrome P450; Region: p450; cl12078 710686000520 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686000521 cyclase homology domain; Region: CHD; cd07302 710686000522 nucleotidyl binding site; other site 710686000523 metal binding site [ion binding]; metal-binding site 710686000524 dimer interface [polypeptide binding]; other site 710686000525 Predicted ATPase [General function prediction only]; Region: COG3903 710686000526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686000527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686000528 DNA binding residues [nucleotide binding] 710686000529 dimerization interface [polypeptide binding]; other site 710686000530 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710686000531 nucleoside/Zn binding site; other site 710686000532 dimer interface [polypeptide binding]; other site 710686000533 catalytic motif [active] 710686000534 ykkC-yxkD leader; Mycsm_06826 710686000535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686000536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686000537 dimerization interface [polypeptide binding]; other site 710686000538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686000539 ATP binding site [chemical binding]; other site 710686000540 Mg2+ binding site [ion binding]; other site 710686000541 G-X-G motif; other site 710686000542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686000543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686000544 active site 710686000545 phosphorylation site [posttranslational modification] 710686000546 intermolecular recognition site; other site 710686000547 dimerization interface [polypeptide binding]; other site 710686000548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686000549 DNA binding site [nucleotide binding] 710686000550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 710686000551 phosphopeptide binding site; other site 710686000552 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710686000553 active site 710686000554 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 710686000555 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 710686000556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000557 sequence-specific DNA binding site [nucleotide binding]; other site 710686000558 salt bridge; other site 710686000559 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 710686000560 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710686000561 CGNR zinc finger; Region: zf-CGNR; pfam11706 710686000562 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 710686000563 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710686000564 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 710686000565 Walker A/P-loop; other site 710686000566 ATP binding site [chemical binding]; other site 710686000567 Q-loop/lid; other site 710686000568 ABC transporter signature motif; other site 710686000569 Walker B; other site 710686000570 D-loop; other site 710686000571 H-loop/switch region; other site 710686000572 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710686000573 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710686000574 Walker A/P-loop; other site 710686000575 ATP binding site [chemical binding]; other site 710686000576 Q-loop/lid; other site 710686000577 ABC transporter signature motif; other site 710686000578 Walker B; other site 710686000579 D-loop; other site 710686000580 H-loop/switch region; other site 710686000581 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710686000582 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710686000583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686000584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686000585 Uncharacterized conserved protein [Function unknown]; Region: COG3349 710686000586 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686000587 cyclase homology domain; Region: CHD; cd07302 710686000588 nucleotidyl binding site; other site 710686000589 metal binding site [ion binding]; metal-binding site 710686000590 dimer interface [polypeptide binding]; other site 710686000591 AAA ATPase domain; Region: AAA_16; pfam13191 710686000592 Predicted ATPase [General function prediction only]; Region: COG3899 710686000593 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710686000594 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710686000595 substrate binding pocket [chemical binding]; other site 710686000596 chain length determination region; other site 710686000597 substrate-Mg2+ binding site; other site 710686000598 catalytic residues [active] 710686000599 aspartate-rich region 1; other site 710686000600 active site lid residues [active] 710686000601 aspartate-rich region 2; other site 710686000602 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710686000603 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 710686000604 catalytic residues [active] 710686000605 catalytic nucleophile [active] 710686000606 Recombinase; Region: Recombinase; pfam07508 710686000607 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 710686000608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686000609 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686000610 cyclase homology domain; Region: CHD; cd07302 710686000611 nucleotidyl binding site; other site 710686000612 metal binding site [ion binding]; metal-binding site 710686000613 dimer interface [polypeptide binding]; other site 710686000614 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686000615 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686000616 cyclase homology domain; Region: CHD; cd07302 710686000617 nucleotidyl binding site; other site 710686000618 metal binding site [ion binding]; metal-binding site 710686000619 dimer interface [polypeptide binding]; other site 710686000620 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 710686000621 AAA-like domain; Region: AAA_10; pfam12846 710686000622 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710686000623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000624 Walker A motif; other site 710686000625 ATP binding site [chemical binding]; other site 710686000626 Walker B motif; other site 710686000627 arginine finger; other site 710686000628 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686000629 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710686000630 Ligand binding site; other site 710686000631 Putative Catalytic site; other site 710686000632 DXD motif; other site 710686000633 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710686000634 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710686000635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710686000636 active site 710686000637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686000638 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 710686000639 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710686000640 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710686000641 active site 710686000642 metal binding site [ion binding]; metal-binding site 710686000643 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000645 salt bridge; other site 710686000646 non-specific DNA binding site [nucleotide binding]; other site 710686000647 sequence-specific DNA binding site [nucleotide binding]; other site 710686000648 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 710686000649 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 710686000650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000651 Walker A motif; other site 710686000652 ATP binding site [chemical binding]; other site 710686000653 Walker B motif; other site 710686000654 arginine finger; other site 710686000655 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710686000656 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 710686000657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686000658 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686000659 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686000660 MarR family; Region: MarR_2; cl17246 710686000661 Part of AAA domain; Region: AAA_19; pfam13245 710686000662 Family description; Region: UvrD_C_2; pfam13538 710686000663 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710686000664 active site 710686000665 catalytic site [active] 710686000666 substrate binding site [chemical binding]; other site 710686000667 Fic/DOC family; Region: Fic; cl00960 710686000668 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 710686000669 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 710686000670 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 710686000671 cofactor binding site; other site 710686000672 DNA binding site [nucleotide binding] 710686000673 substrate interaction site [chemical binding]; other site 710686000674 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686000675 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686000676 phosphopeptide binding site; other site 710686000677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000679 non-specific DNA binding site [nucleotide binding]; other site 710686000680 salt bridge; other site 710686000681 sequence-specific DNA binding site [nucleotide binding]; other site 710686000682 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686000683 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686000684 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686000685 active site 710686000686 ATP binding site [chemical binding]; other site 710686000687 substrate binding site [chemical binding]; other site 710686000688 activation loop (A-loop); other site 710686000689 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 710686000690 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686000691 intersubunit interface [polypeptide binding]; other site 710686000692 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710686000693 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 710686000694 RNA/DNA hybrid binding site [nucleotide binding]; other site 710686000695 active site 710686000696 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 710686000697 DNA methylase; Region: N6_N4_Mtase; pfam01555 710686000698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710686000699 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 710686000700 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 710686000701 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 710686000702 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710686000703 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 710686000704 active site 710686000705 DNA binding site [nucleotide binding] 710686000706 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710686000707 DNA binding site [nucleotide binding] 710686000708 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 710686000709 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000710 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710686000711 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686000712 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686000713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000715 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 710686000716 DNA protecting protein DprA; Region: dprA; TIGR00732 710686000717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 710686000718 active site 710686000719 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710686000720 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686000721 DNA binding residues [nucleotide binding] 710686000722 Transglycosylase; Region: Transgly; pfam00912 710686000723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686000724 transcriptional regulator NarP; Provisional; Region: PRK10403 710686000725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686000726 active site 710686000727 phosphorylation site [posttranslational modification] 710686000728 intermolecular recognition site; other site 710686000729 dimerization interface [polypeptide binding]; other site 710686000730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686000731 DNA binding residues [nucleotide binding] 710686000732 PIN domain; Region: PIN_3; cl17397 710686000733 RES domain; Region: RES; pfam08808 710686000734 RES domain; Region: RES; pfam08808 710686000735 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 710686000736 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 710686000737 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 710686000738 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 710686000739 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 710686000740 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 710686000741 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 710686000742 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 710686000743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686000744 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 710686000745 active site 710686000746 NTP binding site [chemical binding]; other site 710686000747 metal binding triad [ion binding]; metal-binding site 710686000748 antibiotic binding site [chemical binding]; other site 710686000749 Protein of unknown function DUF86; Region: DUF86; cl01031 710686000750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000751 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710686000752 Walker A motif; other site 710686000753 ATP binding site [chemical binding]; other site 710686000754 Walker B motif; other site 710686000755 arginine finger; other site 710686000756 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710686000757 PPE family; Region: PPE; pfam00823 710686000758 EspG family; Region: ESX-1_EspG; pfam14011 710686000759 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 710686000760 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710686000761 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710686000762 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710686000763 Subtilase family; Region: Peptidase_S8; pfam00082 710686000764 active site 710686000765 catalytic residues [active] 710686000766 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710686000767 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710686000768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000769 P-loop; other site 710686000770 Magnesium ion binding site [ion binding]; other site 710686000771 AAA-like domain; Region: AAA_10; pfam12846 710686000772 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710686000773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000774 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710686000775 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000776 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000777 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710686000778 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710686000779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000780 Walker A motif; other site 710686000781 ATP binding site [chemical binding]; other site 710686000782 Walker B motif; other site 710686000783 arginine finger; other site 710686000784 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710686000785 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710686000786 catalytic residue [active] 710686000787 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710686000788 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000789 AAA domain; Region: AAA_31; pfam13614 710686000790 P-loop; other site 710686000791 Magnesium ion binding site [ion binding]; other site 710686000792 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000793 Magnesium ion binding site [ion binding]; other site 710686000794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000796 non-specific DNA binding site [nucleotide binding]; other site 710686000797 salt bridge; other site 710686000798 sequence-specific DNA binding site [nucleotide binding]; other site 710686000799 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000801 non-specific DNA binding site [nucleotide binding]; other site 710686000802 salt bridge; other site 710686000803 sequence-specific DNA binding site [nucleotide binding]; other site 710686000804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000805 non-specific DNA binding site [nucleotide binding]; other site 710686000806 salt bridge; other site 710686000807 sequence-specific DNA binding site [nucleotide binding]; other site 710686000808 Transcription factor WhiB; Region: Whib; pfam02467 710686000809 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 710686000810 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 710686000811 replicative DNA helicase; Provisional; Region: PRK05636 710686000812 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710686000813 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710686000814 Walker A motif; other site 710686000815 ATP binding site [chemical binding]; other site 710686000816 Walker B motif; other site 710686000817 DNA binding loops [nucleotide binding] 710686000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686000819 DNA-binding site [nucleotide binding]; DNA binding site 710686000820 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 710686000821 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710686000822 Active Sites [active] 710686000823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686000824 S-adenosylmethionine binding site [chemical binding]; other site 710686000825 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710686000826 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710686000827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686000828 ATP binding site [chemical binding]; other site 710686000829 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710686000830 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710686000831 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 710686000832 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 710686000833 active site 710686000834 Transcription factor WhiB; Region: Whib; pfam02467 710686000835 Transcription factor WhiB; Region: Whib; pfam02467 710686000836 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 710686000837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000839 non-specific DNA binding site [nucleotide binding]; other site 710686000840 salt bridge; other site 710686000841 sequence-specific DNA binding site [nucleotide binding]; other site 710686000842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000843 salt bridge; other site 710686000844 non-specific DNA binding site [nucleotide binding]; other site 710686000845 sequence-specific DNA binding site [nucleotide binding]; other site 710686000846 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710686000847 active site 710686000848 catalytic site [active] 710686000849 substrate binding site [chemical binding]; other site 710686000850 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710686000851 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 710686000852 active site 710686000853 Fe-S cluster binding site [ion binding]; other site 710686000854 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 710686000855 Protein of unknown function (DUF499); Region: DUF499; pfam04465 710686000856 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 710686000857 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710686000858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686000859 ATP binding site [chemical binding]; other site 710686000860 putative Mg++ binding site [ion binding]; other site 710686000861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686000862 nucleotide binding region [chemical binding]; other site 710686000863 ATP-binding site [chemical binding]; other site 710686000864 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 710686000865 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 710686000866 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 710686000867 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 710686000868 short chain dehydrogenase; Validated; Region: PRK07069 710686000869 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710686000870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686000871 ATP binding site [chemical binding]; other site 710686000872 putative Mg++ binding site [ion binding]; other site 710686000873 nucleotide binding region [chemical binding]; other site 710686000874 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710686000875 ATP-binding site [chemical binding]; other site 710686000876 Helicase associated domain; Region: HA; pfam03457 710686000877 Helicase associated domain; Region: HA; pfam03457 710686000878 Helicase associated domain; Region: HA; pfam03457 710686000879 Helicase associated domain; Region: HA; pfam03457 710686000880 Helicase associated domain; Region: HA; pfam03457 710686000881 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710686000882 acyl carrier protein; Provisional; Region: acpP; PRK00982 710686000883 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 710686000884 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 710686000885 Probable transposase; Region: OrfB_IS605; pfam01385 710686000886 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 710686000887 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 710686000888 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 710686000889 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 710686000890 Fic/DOC family; Region: Fic; cl00960 710686000891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686000892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686000893 active site 710686000894 ATP binding site [chemical binding]; other site 710686000895 substrate binding site [chemical binding]; other site 710686000896 activation loop (A-loop); other site 710686000897 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710686000898 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 710686000899 active site 710686000900 DNA binding site [nucleotide binding] 710686000901 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710686000902 DNA binding site [nucleotide binding] 710686000903 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000904 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 710686000905 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 710686000906 putative active site [active] 710686000907 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710686000908 Cutinase; Region: Cutinase; pfam01083 710686000909 spermidine synthase; Provisional; Region: PRK03612 710686000910 AAA-like domain; Region: AAA_10; pfam12846 710686000911 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686000912 NlpC/P60 family; Region: NLPC_P60; cl17555 710686000913 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120 710686000914 Walker A motif; other site 710686000915 ATP binding site [chemical binding]; other site 710686000916 Walker B motif; other site 710686000917 Bacterial transcriptional activator domain; Region: BTAD; smart01043 710686000918 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710686000919 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 710686000920 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710686000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000922 Walker A motif; other site 710686000923 ATP binding site [chemical binding]; other site 710686000924 Walker B motif; other site 710686000925 arginine finger; other site 710686000926 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710686000927 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710686000928 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000929 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710686000930 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686000931 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710686000932 PPE family; Region: PPE; pfam00823 710686000933 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710686000934 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 710686000935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686000936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686000937 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710686000938 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710686000939 active site 710686000940 catalytic residues [active] 710686000941 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 710686000942 AAA domain; Region: AAA_31; pfam13614 710686000943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686000944 P-loop; other site 710686000945 Magnesium ion binding site [ion binding]; other site 710686000946 EspG family; Region: ESX-1_EspG; pfam14011 710686000947 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 710686000948 Helix-turn-helix domain; Region: HTH_38; pfam13936 710686000949 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686000950 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686000951 Helix-turn-helix; Region: HTH_3; pfam01381 710686000952 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 710686000953 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 710686000954 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 710686000955 substrate binding pocket [chemical binding]; other site 710686000956 active site 710686000957 iron coordination sites [ion binding]; other site 710686000958 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710686000959 Active Sites [active] 710686000960 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 710686000961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686000962 Walker A motif; other site 710686000963 ATP binding site [chemical binding]; other site 710686000964 Walker B motif; other site 710686000965 arginine finger; other site 710686000966 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 710686000967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 710686000968 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686000969 AAA domain; Region: AAA_30; pfam13604 710686000970 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710686000971 AAA domain; Region: AAA_12; pfam13087 710686000972 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710686000973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686000974 S-adenosylmethionine binding site [chemical binding]; other site 710686000975 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710686000976 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710686000977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686000978 ATP binding site [chemical binding]; other site 710686000979 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710686000980 DNA polymerase III subunit beta; Validated; Region: PRK07761 710686000981 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710686000982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686000983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000984 salt bridge; other site 710686000985 non-specific DNA binding site [nucleotide binding]; other site 710686000986 sequence-specific DNA binding site [nucleotide binding]; other site 710686000987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686000988 salt bridge; other site 710686000989 non-specific DNA binding site [nucleotide binding]; other site 710686000990 sequence-specific DNA binding site [nucleotide binding]; other site 710686000991 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710686000992 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710686000993 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 710686000994 replicative DNA helicase; Region: DnaB; TIGR00665 710686000995 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710686000996 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710686000997 Walker A motif; other site 710686000998 ATP binding site [chemical binding]; other site 710686000999 Walker B motif; other site 710686001000 DNA binding loops [nucleotide binding] 710686001001 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 710686001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686001003 ATP binding site [chemical binding]; other site 710686001004 putative Mg++ binding site [ion binding]; other site 710686001005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686001006 nucleotide binding region [chemical binding]; other site 710686001007 ATP-binding site [chemical binding]; other site 710686001008 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 710686001009 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 710686001010 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 710686001011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686001012 Walker A motif; other site 710686001013 ATP binding site [chemical binding]; other site 710686001014 Walker B motif; other site 710686001015 arginine finger; other site 710686001016 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710686001017 DnaA box-binding interface [nucleotide binding]; other site 710686001018 DNA polymerase III subunit beta; Validated; Region: PRK07761 710686001019 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 710686001020 putative DNA binding surface [nucleotide binding]; other site 710686001021 dimer interface [polypeptide binding]; other site 710686001022 beta-clamp/clamp loader binding surface; other site 710686001023 beta-clamp/translesion DNA polymerase binding surface; other site 710686001024 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686001025 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 710686001026 recombination protein F; Reviewed; Region: recF; PRK00064 710686001027 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 710686001028 Walker A/P-loop; other site 710686001029 ATP binding site [chemical binding]; other site 710686001030 Q-loop/lid; other site 710686001031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686001032 ABC transporter signature motif; other site 710686001033 Walker B; other site 710686001034 D-loop; other site 710686001035 H-loop/switch region; other site 710686001036 hypothetical protein; Provisional; Region: PRK03195 710686001037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710686001038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686001039 Mg2+ binding site [ion binding]; other site 710686001040 G-X-G motif; other site 710686001041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710686001042 anchoring element; other site 710686001043 dimer interface [polypeptide binding]; other site 710686001044 ATP binding site [chemical binding]; other site 710686001045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710686001046 active site 710686001047 putative metal-binding site [ion binding]; other site 710686001048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710686001049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 710686001050 CAP-like domain; other site 710686001051 active site 710686001052 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 710686001053 protein-splicing catalytic site; other site 710686001054 thioester formation/cholesterol transfer; other site 710686001055 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 710686001056 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 710686001057 DNA gyrase subunit A; Validated; Region: PRK05560 710686001058 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710686001059 primary dimer interface [polypeptide binding]; other site 710686001060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710686001066 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 710686001067 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 710686001068 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 710686001069 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 710686001070 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 710686001071 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710686001072 active site 710686001073 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710686001074 putative septation inhibitor protein; Reviewed; Region: PRK00159 710686001075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710686001076 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710686001077 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 710686001078 Glutamine amidotransferase class-I; Region: GATase; pfam00117 710686001079 glutamine binding [chemical binding]; other site 710686001080 catalytic triad [active] 710686001081 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686001082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686001083 active site 710686001084 ATP binding site [chemical binding]; other site 710686001085 substrate binding site [chemical binding]; other site 710686001086 activation loop (A-loop); other site 710686001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 710686001088 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710686001089 PASTA domain; Region: PASTA; smart00740 710686001090 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710686001091 PASTA domain; Region: PASTA; smart00740 710686001092 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686001093 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686001094 active site 710686001095 ATP binding site [chemical binding]; other site 710686001096 substrate binding site [chemical binding]; other site 710686001097 activation loop (A-loop); other site 710686001098 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710686001099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710686001100 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 710686001101 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710686001102 active site 710686001103 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686001104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686001105 phosphopeptide binding site; other site 710686001106 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 710686001107 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686001108 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686001109 phosphopeptide binding site; other site 710686001110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001112 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686001113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686001114 molybdopterin cofactor binding site; other site 710686001115 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710686001116 putative molybdopterin cofactor binding site; other site 710686001117 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 710686001118 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710686001119 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686001120 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710686001121 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686001122 active site 2 [active] 710686001123 Predicted acetyltransferase [General function prediction only]; Region: COG2388 710686001124 Pirin-related protein [General function prediction only]; Region: COG1741 710686001125 Pirin; Region: Pirin; pfam02678 710686001126 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710686001127 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710686001128 hypothetical protein; Provisional; Region: PRK02268 710686001129 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710686001130 dimerization domain swap beta strand [polypeptide binding]; other site 710686001131 regulatory protein interface [polypeptide binding]; other site 710686001132 active site 710686001133 regulatory phosphorylation site [posttranslational modification]; other site 710686001134 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710686001135 active site 710686001136 phosphorylation site [posttranslational modification] 710686001137 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 710686001138 active site 710686001139 P-loop; other site 710686001140 phosphorylation site [posttranslational modification] 710686001141 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 710686001142 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710686001143 putative substrate binding site [chemical binding]; other site 710686001144 putative ATP binding site [chemical binding]; other site 710686001145 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710686001146 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 710686001147 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710686001148 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710686001149 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710686001150 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710686001151 Pirin-related protein [General function prediction only]; Region: COG1741 710686001152 Pirin; Region: Pirin; pfam02678 710686001153 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710686001154 CsbD-like; Region: CsbD; pfam05532 710686001155 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710686001156 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710686001157 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710686001158 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686001159 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710686001160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001164 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686001165 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686001166 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 710686001167 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710686001168 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710686001169 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 710686001170 NAD(P) binding site [chemical binding]; other site 710686001171 catalytic residues [active] 710686001172 short chain dehydrogenase; Provisional; Region: PRK07791 710686001173 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 710686001174 NAD binding site [chemical binding]; other site 710686001175 homodimer interface [polypeptide binding]; other site 710686001176 active site 710686001177 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686001178 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710686001179 NAD(P) binding site [chemical binding]; other site 710686001180 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710686001181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686001182 motif II; other site 710686001183 Protein of unknown function (DUF456); Region: DUF456; pfam04306 710686001184 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 710686001185 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 710686001186 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 710686001187 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 710686001188 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 710686001189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001190 FAD binding site [chemical binding]; other site 710686001191 substrate binding site [chemical binding]; other site 710686001192 catalytic base [active] 710686001193 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 710686001194 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686001195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686001196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686001197 ATP binding site [chemical binding]; other site 710686001198 Mg2+ binding site [ion binding]; other site 710686001199 G-X-G motif; other site 710686001200 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686001201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001202 S-adenosylmethionine binding site [chemical binding]; other site 710686001203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686001205 active site 710686001206 phosphorylation site [posttranslational modification] 710686001207 intermolecular recognition site; other site 710686001208 dimerization interface [polypeptide binding]; other site 710686001209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686001210 DNA binding residues [nucleotide binding] 710686001211 dimerization interface [polypeptide binding]; other site 710686001212 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686001213 Cytochrome P450; Region: p450; cl12078 710686001214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001216 active site 710686001217 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 710686001218 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 710686001219 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 710686001220 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 710686001221 ligand binding site [chemical binding]; other site 710686001222 homodimer interface [polypeptide binding]; other site 710686001223 NAD(P) binding site [chemical binding]; other site 710686001224 trimer interface B [polypeptide binding]; other site 710686001225 trimer interface A [polypeptide binding]; other site 710686001226 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 710686001227 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710686001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686001229 dimer interface [polypeptide binding]; other site 710686001230 conserved gate region; other site 710686001231 putative PBP binding loops; other site 710686001232 ABC-ATPase subunit interface; other site 710686001233 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710686001234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686001235 substrate binding pocket [chemical binding]; other site 710686001236 membrane-bound complex binding site; other site 710686001237 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710686001238 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710686001239 Walker A/P-loop; other site 710686001240 ATP binding site [chemical binding]; other site 710686001241 Q-loop/lid; other site 710686001242 ABC transporter signature motif; other site 710686001243 Walker B; other site 710686001244 D-loop; other site 710686001245 H-loop/switch region; other site 710686001246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001248 hypothetical protein; Provisional; Region: PRK06185 710686001249 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686001250 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686001251 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001252 active site 710686001253 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686001254 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710686001255 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710686001256 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 710686001257 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686001258 NAD(P) binding site [chemical binding]; other site 710686001259 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710686001260 active site 710686001261 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710686001262 putative hydrophobic ligand binding site [chemical binding]; other site 710686001263 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710686001264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686001265 DNA-binding site [nucleotide binding]; DNA binding site 710686001266 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 710686001267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001268 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686001269 acyl-activating enzyme (AAE) consensus motif; other site 710686001270 acyl-activating enzyme (AAE) consensus motif; other site 710686001271 putative AMP binding site [chemical binding]; other site 710686001272 putative active site [active] 710686001273 putative CoA binding site [chemical binding]; other site 710686001274 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686001275 Permease; Region: Permease; pfam02405 710686001276 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686001277 Permease; Region: Permease; pfam02405 710686001278 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686001279 mce related protein; Region: MCE; pfam02470 710686001280 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686001281 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710686001282 mce related protein; Region: MCE; pfam02470 710686001283 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686001284 mce related protein; Region: MCE; pfam02470 710686001285 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686001286 mce related protein; Region: MCE; pfam02470 710686001287 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686001288 mce related protein; Region: MCE; pfam02470 710686001289 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686001290 mce related protein; Region: MCE; pfam02470 710686001291 RDD family; Region: RDD; pfam06271 710686001292 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710686001293 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686001294 short chain dehydrogenase; Provisional; Region: PRK06914 710686001295 NADP binding site [chemical binding]; other site 710686001296 active site 710686001297 steroid binding site; other site 710686001298 Phosphotransferase enzyme family; Region: APH; pfam01636 710686001299 Fructosamine kinase; Region: Fructosamin_kin; cl17579 710686001300 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 710686001301 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 710686001302 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710686001303 Pirin-related protein [General function prediction only]; Region: COG1741 710686001304 Pirin; Region: Pirin; pfam02678 710686001305 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710686001306 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686001307 MarR family; Region: MarR_2; pfam12802 710686001308 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710686001309 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686001310 NAD binding site [chemical binding]; other site 710686001311 catalytic Zn binding site [ion binding]; other site 710686001312 substrate binding site [chemical binding]; other site 710686001313 structural Zn binding site [ion binding]; other site 710686001314 RNA polymerase factor sigma-70; Validated; Region: PRK08241 710686001315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686001316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686001317 DNA binding residues [nucleotide binding] 710686001318 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710686001319 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 710686001320 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710686001321 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686001322 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710686001323 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 710686001324 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 710686001325 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710686001326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001327 S-adenosylmethionine binding site [chemical binding]; other site 710686001328 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686001329 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710686001330 intersubunit interface [polypeptide binding]; other site 710686001331 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 710686001332 6-phosphogluconate dehydratase; Region: edd; TIGR01196 710686001333 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710686001334 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710686001335 putative homotetramer interface [polypeptide binding]; other site 710686001336 putative homodimer interface [polypeptide binding]; other site 710686001337 putative allosteric switch controlling residues; other site 710686001338 putative metal binding site [ion binding]; other site 710686001339 putative homodimer-homodimer interface [polypeptide binding]; other site 710686001340 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 710686001341 Nitrogen regulatory protein P-II; Region: P-II; smart00938 710686001342 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710686001343 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686001344 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686001345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686001346 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686001347 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 710686001348 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 710686001349 active site 710686001350 Zn binding site [ion binding]; other site 710686001351 CoA binding domain; Region: CoA_binding; cl17356 710686001352 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686001353 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 710686001354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686001355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686001356 active site 710686001357 phosphorylation site [posttranslational modification] 710686001358 intermolecular recognition site; other site 710686001359 dimerization interface [polypeptide binding]; other site 710686001360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686001361 DNA binding site [nucleotide binding] 710686001362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686001363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686001364 phosphorylation site [posttranslational modification] 710686001365 dimer interface [polypeptide binding]; other site 710686001366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686001367 ATP binding site [chemical binding]; other site 710686001368 Mg2+ binding site [ion binding]; other site 710686001369 G-X-G motif; other site 710686001370 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 710686001371 Peptidase family M23; Region: Peptidase_M23; pfam01551 710686001372 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710686001373 Predicted integral membrane protein [Function unknown]; Region: COG0392 710686001374 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710686001375 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710686001376 MMPL family; Region: MMPL; pfam03176 710686001377 MMPL family; Region: MMPL; pfam03176 710686001378 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 710686001379 LabA_like proteins; Region: LabA_like; cd06167 710686001380 putative metal binding site [ion binding]; other site 710686001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001382 S-adenosylmethionine binding site [chemical binding]; other site 710686001383 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 710686001384 active site 710686001385 substrate-binding site [chemical binding]; other site 710686001386 metal-binding site [ion binding] 710686001387 GTP binding site [chemical binding]; other site 710686001388 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686001389 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686001390 cyclase homology domain; Region: CHD; cd07302 710686001391 nucleotidyl binding site; other site 710686001392 metal binding site [ion binding]; metal-binding site 710686001393 dimer interface [polypeptide binding]; other site 710686001394 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686001395 cyclase homology domain; Region: CHD; cd07302 710686001396 nucleotidyl binding site; other site 710686001397 metal binding site [ion binding]; metal-binding site 710686001398 dimer interface [polypeptide binding]; other site 710686001399 Predicted ATPase [General function prediction only]; Region: COG3903 710686001400 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686001401 cyclase homology domain; Region: CHD; cd07302 710686001402 nucleotidyl binding site; other site 710686001403 metal binding site [ion binding]; metal-binding site 710686001404 dimer interface [polypeptide binding]; other site 710686001405 Predicted ATPase [General function prediction only]; Region: COG3903 710686001406 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001407 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710686001408 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686001409 acyl-activating enzyme (AAE) consensus motif; other site 710686001410 acyl-activating enzyme (AAE) consensus motif; other site 710686001411 putative AMP binding site [chemical binding]; other site 710686001412 putative active site [active] 710686001413 putative CoA binding site [chemical binding]; other site 710686001414 CoA binding site [chemical binding]; other site 710686001415 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686001416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686001417 substrate binding site [chemical binding]; other site 710686001418 oxyanion hole (OAH) forming residues; other site 710686001419 trimer interface [polypeptide binding]; other site 710686001420 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686001421 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686001422 iron-sulfur cluster [ion binding]; other site 710686001423 [2Fe-2S] cluster binding site [ion binding]; other site 710686001424 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686001425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686001426 DNA-binding site [nucleotide binding]; DNA binding site 710686001427 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710686001428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001429 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001430 active site 710686001431 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686001432 active site 2 [active] 710686001433 active site 1 [active] 710686001434 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686001435 active site 2 [active] 710686001436 active site 1 [active] 710686001437 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686001438 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710686001439 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686001440 active site 710686001441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686001442 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686001443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001444 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686001445 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001446 active site 710686001447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001448 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001449 active site 710686001450 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710686001451 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686001452 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686001453 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686001454 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710686001455 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686001456 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686001457 acyl-CoA synthetase; Provisional; Region: PRK13382 710686001458 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686001459 acyl-activating enzyme (AAE) consensus motif; other site 710686001460 putative AMP binding site [chemical binding]; other site 710686001461 putative active site [active] 710686001462 putative CoA binding site [chemical binding]; other site 710686001463 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686001464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710686001465 putative acyl-acceptor binding pocket; other site 710686001466 enoyl-CoA hydratase; Provisional; Region: PRK08252 710686001467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686001468 substrate binding site [chemical binding]; other site 710686001469 oxyanion hole (OAH) forming residues; other site 710686001470 trimer interface [polypeptide binding]; other site 710686001471 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 710686001472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001476 active site 710686001477 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710686001478 RibD C-terminal domain; Region: RibD_C; cl17279 710686001479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001481 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686001482 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686001483 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 710686001484 FAD binding site [chemical binding]; other site 710686001485 substrate binding site [chemical binding]; other site 710686001486 catalytic residues [active] 710686001487 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686001488 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710686001489 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686001490 NAD binding site [chemical binding]; other site 710686001491 catalytic residues [active] 710686001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001493 S-adenosylmethionine binding site [chemical binding]; other site 710686001494 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686001495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686001496 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 710686001497 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710686001498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710686001500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001501 AMP binding site [chemical binding]; other site 710686001502 active site 710686001503 acyl-activating enzyme (AAE) consensus motif; other site 710686001504 CoA binding site [chemical binding]; other site 710686001505 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 710686001506 active site 710686001507 substrate binding pocket [chemical binding]; other site 710686001508 homodimer interaction site [polypeptide binding]; other site 710686001509 acetolactate synthase; Reviewed; Region: PRK08322 710686001510 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686001511 PYR/PP interface [polypeptide binding]; other site 710686001512 dimer interface [polypeptide binding]; other site 710686001513 TPP binding site [chemical binding]; other site 710686001514 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686001515 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 710686001516 TPP-binding site [chemical binding]; other site 710686001517 dimer interface [polypeptide binding]; other site 710686001518 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 710686001519 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 710686001520 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 710686001521 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 710686001522 putative acyl-acceptor binding pocket; other site 710686001523 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 710686001524 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710686001525 nucleophile elbow; other site 710686001526 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710686001527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710686001528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686001529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001531 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 710686001532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686001533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686001534 Walker A/P-loop; other site 710686001535 ATP binding site [chemical binding]; other site 710686001536 Q-loop/lid; other site 710686001537 ABC transporter signature motif; other site 710686001538 Walker B; other site 710686001539 D-loop; other site 710686001540 H-loop/switch region; other site 710686001541 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710686001542 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 710686001543 substrate binding site [chemical binding]; other site 710686001544 ATP binding site [chemical binding]; other site 710686001545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710686001546 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686001547 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686001548 active site 2 [active] 710686001549 active site 1 [active] 710686001550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 710686001551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686001552 NAD(P) binding site [chemical binding]; other site 710686001553 active site 710686001554 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 710686001555 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686001556 dimer interface [polypeptide binding]; other site 710686001557 active site 710686001558 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686001559 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686001560 NHL repeat; Region: NHL; pfam01436 710686001561 NHL repeat; Region: NHL; pfam01436 710686001562 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 710686001563 NHL repeat; Region: NHL; pfam01436 710686001564 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686001565 NHL repeat; Region: NHL; pfam01436 710686001566 NHL repeat; Region: NHL; pfam01436 710686001567 NHL repeat; Region: NHL; pfam01436 710686001568 NHL repeat; Region: NHL; pfam01436 710686001569 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686001570 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686001571 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686001572 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 710686001573 FAD binding site [chemical binding]; other site 710686001574 substrate binding site [chemical binding]; other site 710686001575 catalytic residues [active] 710686001576 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686001577 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686001578 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686001579 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686001580 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710686001581 active site 710686001582 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686001583 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686001584 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 710686001585 KR domain; Region: KR; pfam08659 710686001586 NADP binding site [chemical binding]; other site 710686001587 active site 710686001588 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686001589 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710686001590 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686001591 active site 710686001592 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686001593 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710686001594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686001595 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 710686001596 Enoylreductase; Region: PKS_ER; smart00829 710686001597 NAD(P) binding site [chemical binding]; other site 710686001598 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710686001599 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710686001600 putative NADP binding site [chemical binding]; other site 710686001601 active site 710686001602 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686001603 peptide synthase; Provisional; Region: PRK12316 710686001604 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686001605 acyl-CoA synthetase; Validated; Region: PRK05850 710686001606 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686001607 acyl-activating enzyme (AAE) consensus motif; other site 710686001608 active site 710686001609 PE-PPE domain; Region: PE-PPE; pfam08237 710686001610 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686001611 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710686001612 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686001613 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 710686001614 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686001615 catalytic loop [active] 710686001616 iron binding site [ion binding]; other site 710686001617 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 710686001618 L-aspartate oxidase; Provisional; Region: PRK06175 710686001619 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710686001620 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710686001621 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710686001622 tetramer interface [polypeptide binding]; other site 710686001623 active site 710686001624 Mg2+/Mn2+ binding site [ion binding]; other site 710686001625 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 710686001626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686001627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686001628 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710686001629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710686001630 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 710686001631 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 710686001632 E-class dimer interface [polypeptide binding]; other site 710686001633 P-class dimer interface [polypeptide binding]; other site 710686001634 active site 710686001635 Cu2+ binding site [ion binding]; other site 710686001636 Zn2+ binding site [ion binding]; other site 710686001637 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710686001638 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710686001639 putative active site [active] 710686001640 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710686001641 putative active site [active] 710686001642 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 710686001643 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710686001644 active site 710686001645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710686001646 DNA binding site [nucleotide binding] 710686001647 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 710686001648 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 710686001649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001650 S-adenosylmethionine binding site [chemical binding]; other site 710686001651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686001652 Coenzyme A binding pocket [chemical binding]; other site 710686001653 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 710686001654 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 710686001655 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 710686001656 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 710686001657 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 710686001658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686001659 intersubunit interface [polypeptide binding]; other site 710686001660 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710686001661 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686001662 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686001663 NAD(P) binding site [chemical binding]; other site 710686001664 catalytic residues [active] 710686001665 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 710686001666 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001667 active site 710686001668 AMP binding site [chemical binding]; other site 710686001669 short chain dehydrogenase; Provisional; Region: PRK08267 710686001670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686001671 NAD(P) binding site [chemical binding]; other site 710686001672 active site 710686001673 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710686001674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001676 Lysine efflux permease [General function prediction only]; Region: COG1279 710686001677 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 710686001678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686001679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710686001680 dimerization interface [polypeptide binding]; other site 710686001681 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 710686001682 Putative zinc-finger; Region: zf-HC2; pfam13490 710686001683 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710686001684 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710686001685 oligomer interface [polypeptide binding]; other site 710686001686 metal binding site [ion binding]; metal-binding site 710686001687 metal binding site [ion binding]; metal-binding site 710686001688 putative Cl binding site [ion binding]; other site 710686001689 hydrophobic gate; other site 710686001690 periplasmic entrance; other site 710686001691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686001692 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710686001693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686001694 metabolite-proton symporter; Region: 2A0106; TIGR00883 710686001695 putative substrate translocation pore; other site 710686001696 benzoate transport; Region: 2A0115; TIGR00895 710686001697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686001698 putative substrate translocation pore; other site 710686001699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686001700 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 710686001701 nucleotide binding site [chemical binding]; other site 710686001702 CsbD-like; Region: CsbD; cl17424 710686001703 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 710686001704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001706 active site 710686001707 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686001708 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 710686001709 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710686001710 nucleotide binding site [chemical binding]; other site 710686001711 acyl-CoA synthetase; Validated; Region: PRK07788 710686001712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686001714 active site 710686001715 CoA binding site [chemical binding]; other site 710686001716 AMP binding site [chemical binding]; other site 710686001717 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710686001718 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 710686001719 homodimer interface [polypeptide binding]; other site 710686001720 substrate-cofactor binding pocket; other site 710686001721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686001722 catalytic residue [active] 710686001723 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710686001724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686001725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686001726 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710686001727 dimerization interface [polypeptide binding]; other site 710686001728 substrate binding pocket [chemical binding]; other site 710686001729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686001731 active site 710686001732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686001733 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710686001734 FAD binding site [chemical binding]; other site 710686001735 substrate binding site [chemical binding]; other site 710686001736 catalytic base [active] 710686001737 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 710686001738 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 710686001739 putative ligand binding site [chemical binding]; other site 710686001740 putative NAD binding site [chemical binding]; other site 710686001741 catalytic site [active] 710686001742 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686001743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686001744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686001745 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 710686001746 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686001747 Zn binding site [ion binding]; other site 710686001748 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710686001749 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686001750 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686001751 cyclase homology domain; Region: CHD; cd07302 710686001752 nucleotidyl binding site; other site 710686001753 metal binding site [ion binding]; metal-binding site 710686001754 dimer interface [polypeptide binding]; other site 710686001755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686001756 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710686001757 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710686001758 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 710686001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001760 S-adenosylmethionine binding site [chemical binding]; other site 710686001761 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 710686001762 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710686001763 Sulfatase; Region: Sulfatase; cl17466 710686001764 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686001765 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686001766 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686001767 active site 710686001768 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710686001769 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710686001770 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710686001771 active site 710686001772 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710686001773 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710686001774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710686001775 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686001776 SnoaL-like domain; Region: SnoaL_3; pfam13474 710686001777 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686001778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686001779 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686001780 iron-sulfur cluster [ion binding]; other site 710686001781 [2Fe-2S] cluster binding site [ion binding]; other site 710686001782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686001783 nucleotide binding site [chemical binding]; other site 710686001784 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 710686001785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686001786 Walker A/P-loop; other site 710686001787 ATP binding site [chemical binding]; other site 710686001788 Q-loop/lid; other site 710686001789 ABC transporter signature motif; other site 710686001790 Walker B; other site 710686001791 D-loop; other site 710686001792 H-loop/switch region; other site 710686001793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686001794 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710686001795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686001796 Walker A/P-loop; other site 710686001797 ATP binding site [chemical binding]; other site 710686001798 Q-loop/lid; other site 710686001799 ABC transporter signature motif; other site 710686001800 Walker B; other site 710686001801 D-loop; other site 710686001802 H-loop/switch region; other site 710686001803 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 710686001804 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710686001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686001806 dimer interface [polypeptide binding]; other site 710686001807 conserved gate region; other site 710686001808 putative PBP binding loops; other site 710686001809 ABC-ATPase subunit interface; other site 710686001810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710686001811 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 710686001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686001813 dimer interface [polypeptide binding]; other site 710686001814 conserved gate region; other site 710686001815 putative PBP binding loops; other site 710686001816 ABC-ATPase subunit interface; other site 710686001817 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 710686001818 peptide binding site [polypeptide binding]; other site 710686001819 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710686001820 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 710686001821 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 710686001822 active site 710686001823 catalytic triad [active] 710686001824 calcium binding site [ion binding]; other site 710686001825 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686001826 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 710686001827 active site 710686001828 catalytic residues [active] 710686001829 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710686001830 hypothetical protein; Provisional; Region: PRK07236 710686001831 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686001832 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 710686001833 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710686001834 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 710686001835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710686001836 FtsX-like permease family; Region: FtsX; pfam02687 710686001837 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 710686001838 FtsX-like permease family; Region: FtsX; pfam02687 710686001839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686001840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686001841 ABC transporter signature motif; other site 710686001842 Walker B; other site 710686001843 D-loop; other site 710686001844 H-loop/switch region; other site 710686001845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710686001846 RNA binding surface [nucleotide binding]; other site 710686001847 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710686001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001849 S-adenosylmethionine binding site [chemical binding]; other site 710686001850 PE-PPE domain; Region: PE-PPE; pfam08237 710686001851 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710686001852 trimer interface [polypeptide binding]; other site 710686001853 active site 710686001854 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710686001855 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 710686001856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686001857 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710686001858 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710686001859 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686001860 Transport protein; Region: actII; TIGR00833 710686001861 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 710686001862 Transport protein; Region: actII; TIGR00833 710686001863 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 710686001864 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 710686001865 substrate binding site; other site 710686001866 tetramer interface; other site 710686001867 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686001868 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686001869 homodimer interface [polypeptide binding]; other site 710686001870 active site 710686001871 TDP-binding site; other site 710686001872 acceptor substrate-binding pocket; other site 710686001873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 710686001874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001875 S-adenosylmethionine binding site [chemical binding]; other site 710686001876 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 710686001877 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686001878 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686001879 homodimer interface [polypeptide binding]; other site 710686001880 active site 710686001881 TDP-binding site; other site 710686001882 acceptor substrate-binding pocket; other site 710686001883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686001884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686001885 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686001886 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686001887 homodimer interface [polypeptide binding]; other site 710686001888 active site 710686001889 TDP-binding site; other site 710686001890 acceptor substrate-binding pocket; other site 710686001891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686001892 S-adenosylmethionine binding site [chemical binding]; other site 710686001893 MbtH-like protein; Region: MbtH; pfam03621 710686001894 Condensation domain; Region: Condensation; pfam00668 710686001895 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686001896 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686001897 acyl-activating enzyme (AAE) consensus motif; other site 710686001898 AMP binding site [chemical binding]; other site 710686001899 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686001900 Condensation domain; Region: Condensation; pfam00668 710686001901 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710686001902 Condensation domain; Region: Condensation; pfam00668 710686001903 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710686001904 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686001905 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686001906 acyl-activating enzyme (AAE) consensus motif; other site 710686001907 AMP binding site [chemical binding]; other site 710686001908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686001909 Condensation domain; Region: Condensation; pfam00668 710686001910 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710686001911 Condensation domain; Region: Condensation; pfam00668 710686001912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710686001913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710686001914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686001915 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686001916 acyl-activating enzyme (AAE) consensus motif; other site 710686001917 AMP binding site [chemical binding]; other site 710686001918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686001919 Condensation domain; Region: Condensation; pfam00668 710686001920 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710686001921 Condensation domain; Region: Condensation; pfam00668 710686001922 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686001923 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686001924 acyl-activating enzyme (AAE) consensus motif; other site 710686001925 AMP binding site [chemical binding]; other site 710686001926 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686001927 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710686001928 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 710686001929 putative NAD(P) binding site [chemical binding]; other site 710686001930 active site 710686001931 putative substrate binding site [chemical binding]; other site 710686001932 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686001933 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686001934 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686001935 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686001936 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686001937 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 710686001938 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 710686001939 substrate binding site; other site 710686001940 tetramer interface; other site 710686001941 YibE/F-like protein; Region: YibE_F; pfam07907 710686001942 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686001943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686001944 substrate binding site [chemical binding]; other site 710686001945 oxyanion hole (OAH) forming residues; other site 710686001946 trimer interface [polypeptide binding]; other site 710686001947 aminotransferase AlaT; Validated; Region: PRK09265 710686001948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686001949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686001950 homodimer interface [polypeptide binding]; other site 710686001951 catalytic residue [active] 710686001952 4Fe-4S binding domain; Region: Fer4; cl02805 710686001953 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710686001954 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710686001955 4Fe-4S binding domain; Region: Fer4; pfam00037 710686001956 Cysteine-rich domain; Region: CCG; pfam02754 710686001957 Cysteine-rich domain; Region: CCG; pfam02754 710686001958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686001959 nucleotide binding site [chemical binding]; other site 710686001960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686001961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686001962 DNA binding residues [nucleotide binding] 710686001963 dimerization interface [polypeptide binding]; other site 710686001964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686001965 nucleotide binding site [chemical binding]; other site 710686001966 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710686001967 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710686001968 G1 box; other site 710686001969 GTP/Mg2+ binding site [chemical binding]; other site 710686001970 G2 box; other site 710686001971 Switch I region; other site 710686001972 G3 box; other site 710686001973 Switch II region; other site 710686001974 G4 box; other site 710686001975 G5 box; other site 710686001976 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710686001977 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710686001978 G1 box; other site 710686001979 GTP/Mg2+ binding site [chemical binding]; other site 710686001980 G2 box; other site 710686001981 Switch I region; other site 710686001982 G3 box; other site 710686001983 Switch II region; other site 710686001984 G4 box; other site 710686001985 G5 box; other site 710686001986 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686001987 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686001988 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 710686001989 dimer interface [polypeptide binding]; other site 710686001990 catalytic triad [active] 710686001991 peroxidatic and resolving cysteines [active] 710686001992 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686001993 TIGR03085 family protein; Region: TIGR03085 710686001994 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 710686001995 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710686001996 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686001997 cyclase homology domain; Region: CHD; cd07302 710686001998 nucleotidyl binding site; other site 710686001999 metal binding site [ion binding]; metal-binding site 710686002000 dimer interface [polypeptide binding]; other site 710686002001 Predicted ATPase [General function prediction only]; Region: COG3899 710686002002 AAA ATPase domain; Region: AAA_16; pfam13191 710686002003 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686002004 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686002005 active site 710686002006 TDP-binding site; other site 710686002007 acceptor substrate-binding pocket; other site 710686002008 homodimer interface [polypeptide binding]; other site 710686002009 L-asparagine permease; Provisional; Region: PRK15049 710686002010 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710686002011 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 710686002012 nucleotide binding site [chemical binding]; other site 710686002013 NEF interaction site [polypeptide binding]; other site 710686002014 SBD interface [polypeptide binding]; other site 710686002015 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710686002016 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 710686002017 dimer interface [polypeptide binding]; other site 710686002018 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710686002019 chaperone protein DnaJ; Provisional; Region: PRK14279 710686002020 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710686002021 HSP70 interaction site [polypeptide binding]; other site 710686002022 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710686002023 Zn binding sites [ion binding]; other site 710686002024 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710686002025 dimer interface [polypeptide binding]; other site 710686002026 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 710686002027 DNA binding residues [nucleotide binding] 710686002028 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686002029 putative dimer interface [polypeptide binding]; other site 710686002030 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 710686002031 active site 710686002032 catalytic residues [active] 710686002033 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 710686002034 heme-binding site [chemical binding]; other site 710686002035 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 710686002036 FMN reductase; Validated; Region: fre; PRK08051 710686002037 FAD binding pocket [chemical binding]; other site 710686002038 FAD binding motif [chemical binding]; other site 710686002039 phosphate binding motif [ion binding]; other site 710686002040 beta-alpha-beta structure motif; other site 710686002041 NAD binding pocket [chemical binding]; other site 710686002042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002044 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686002045 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 710686002046 Clp amino terminal domain; Region: Clp_N; pfam02861 710686002047 Clp amino terminal domain; Region: Clp_N; pfam02861 710686002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686002049 Walker A motif; other site 710686002050 ATP binding site [chemical binding]; other site 710686002051 Walker B motif; other site 710686002052 arginine finger; other site 710686002053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686002054 Walker A motif; other site 710686002055 ATP binding site [chemical binding]; other site 710686002056 Walker B motif; other site 710686002057 arginine finger; other site 710686002058 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710686002059 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686002060 classical (c) SDRs; Region: SDR_c; cd05233 710686002061 NAD(P) binding site [chemical binding]; other site 710686002062 active site 710686002063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710686002064 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710686002065 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 710686002066 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 710686002067 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710686002068 Thioredoxin; Region: Thioredoxin_4; pfam13462 710686002069 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710686002070 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710686002071 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686002072 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686002073 NAD(P) binding site [chemical binding]; other site 710686002074 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 710686002075 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 710686002076 active site 710686002077 intersubunit interface [polypeptide binding]; other site 710686002078 zinc binding site [ion binding]; other site 710686002079 Na+ binding site [ion binding]; other site 710686002080 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 710686002081 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 710686002082 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 710686002083 Peptidase family M50; Region: Peptidase_M50; pfam02163 710686002084 active site 710686002085 putative substrate binding region [chemical binding]; other site 710686002086 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 710686002087 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 710686002088 GDP-binding site [chemical binding]; other site 710686002089 ACT binding site; other site 710686002090 IMP binding site; other site 710686002091 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686002092 CoenzymeA binding site [chemical binding]; other site 710686002093 subunit interaction site [polypeptide binding]; other site 710686002094 PHB binding site; other site 710686002095 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686002096 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686002097 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686002098 Cytochrome P450; Region: p450; cl12078 710686002099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686002100 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686002101 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 710686002102 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710686002103 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 710686002104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686002105 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 710686002106 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 710686002107 active site residue [active] 710686002108 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 710686002109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710686002110 homodimer interface [polypeptide binding]; other site 710686002111 substrate-cofactor binding pocket; other site 710686002112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686002113 catalytic residue [active] 710686002114 short chain dehydrogenase; Provisional; Region: PRK07825 710686002115 classical (c) SDRs; Region: SDR_c; cd05233 710686002116 NAD(P) binding site [chemical binding]; other site 710686002117 active site 710686002118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686002119 Coenzyme A binding pocket [chemical binding]; other site 710686002120 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686002121 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686002122 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710686002123 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 710686002124 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686002125 active site 710686002126 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686002127 non-prolyl cis peptide bond; other site 710686002128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686002129 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 710686002130 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686002131 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686002132 phosphate acetyltransferase; Reviewed; Region: PRK05632 710686002133 DRTGG domain; Region: DRTGG; pfam07085 710686002134 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 710686002135 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 710686002136 propionate/acetate kinase; Provisional; Region: PRK12379 710686002137 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686002138 anti sigma factor interaction site; other site 710686002139 regulatory phosphorylation site [posttranslational modification]; other site 710686002140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686002141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686002142 active site 710686002143 ATP binding site [chemical binding]; other site 710686002144 substrate binding site [chemical binding]; other site 710686002145 activation loop (A-loop); other site 710686002146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686002147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686002148 substrate binding pocket [chemical binding]; other site 710686002149 membrane-bound complex binding site; other site 710686002150 hinge residues; other site 710686002151 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 710686002152 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 710686002153 nudix motif; other site 710686002154 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 710686002155 thiamine phosphate binding site [chemical binding]; other site 710686002156 active site 710686002157 pyrophosphate binding site [ion binding]; other site 710686002158 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710686002159 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686002160 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710686002161 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 710686002162 thiS-thiF/thiG interaction site; other site 710686002163 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 710686002164 ThiS interaction site; other site 710686002165 putative active site [active] 710686002166 tetramer interface [polypeptide binding]; other site 710686002167 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 710686002168 active site 710686002169 catalytic triad [active] 710686002170 oxyanion hole [active] 710686002171 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710686002172 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710686002173 PA/protease or protease-like domain interface [polypeptide binding]; other site 710686002174 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710686002175 Peptidase family M28; Region: Peptidase_M28; pfam04389 710686002176 active site 710686002177 metal binding site [ion binding]; metal-binding site 710686002178 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710686002179 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710686002180 PA/protease or protease-like domain interface [polypeptide binding]; other site 710686002181 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710686002182 Peptidase family M28; Region: Peptidase_M28; pfam04389 710686002183 active site 710686002184 metal binding site [ion binding]; metal-binding site 710686002185 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 710686002186 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710686002187 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686002188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686002189 active site 710686002190 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 710686002191 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710686002192 amino acid transporter; Region: 2A0306; TIGR00909 710686002193 amino acid transporter; Region: 2A0306; TIGR00909 710686002194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002198 Predicted membrane protein [Function unknown]; Region: COG4270 710686002199 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686002200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686002201 Septum formation; Region: Septum_form; pfam13845 710686002202 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710686002203 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 710686002204 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686002205 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 710686002206 dimer interface [polypeptide binding]; other site 710686002207 substrate binding site [chemical binding]; other site 710686002208 ATP binding site [chemical binding]; other site 710686002209 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 710686002210 ThiC-associated domain; Region: ThiC-associated; pfam13667 710686002211 ThiC family; Region: ThiC; pfam01964 710686002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686002213 putative substrate translocation pore; other site 710686002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 710686002215 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686002216 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710686002217 putative acyl-acceptor binding pocket; other site 710686002218 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 710686002219 putative catalytic site [active] 710686002220 putative phosphate binding site [ion binding]; other site 710686002221 active site 710686002222 metal binding site A [ion binding]; metal-binding site 710686002223 DNA binding site [nucleotide binding] 710686002224 putative AP binding site [nucleotide binding]; other site 710686002225 putative metal binding site B [ion binding]; other site 710686002226 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686002227 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710686002228 active site 710686002229 catalytic residues [active] 710686002230 metal binding site [ion binding]; metal-binding site 710686002231 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 710686002232 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710686002233 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 710686002234 E-class dimer interface [polypeptide binding]; other site 710686002235 P-class dimer interface [polypeptide binding]; other site 710686002236 active site 710686002237 Cu2+ binding site [ion binding]; other site 710686002238 Zn2+ binding site [ion binding]; other site 710686002239 carboxylate-amine ligase; Provisional; Region: PRK13517 710686002240 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710686002241 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 710686002242 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686002243 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686002244 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 710686002245 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 710686002246 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 710686002247 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 710686002248 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710686002249 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 710686002250 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 710686002251 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710686002252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710686002253 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 710686002254 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 710686002255 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710686002256 2TM domain; Region: 2TM; pfam13239 710686002257 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 710686002258 putative hydrophobic ligand binding site [chemical binding]; other site 710686002259 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 710686002260 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 710686002261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686002262 Walker A motif; other site 710686002263 ATP binding site [chemical binding]; other site 710686002264 Walker B motif; other site 710686002265 arginine finger; other site 710686002266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686002267 Walker A motif; other site 710686002268 ATP binding site [chemical binding]; other site 710686002269 Walker B motif; other site 710686002270 arginine finger; other site 710686002271 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 710686002272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 710686002273 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 710686002274 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710686002275 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710686002276 dimer interface [polypeptide binding]; other site 710686002277 putative functional site; other site 710686002278 putative MPT binding site; other site 710686002279 short chain dehydrogenase; Provisional; Region: PRK06197 710686002280 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710686002281 putative NAD(P) binding site [chemical binding]; other site 710686002282 active site 710686002283 Uncharacterized conserved protein [Function unknown]; Region: COG3402 710686002284 Predicted membrane protein [Function unknown]; Region: COG3428 710686002285 Bacterial PH domain; Region: DUF304; pfam03703 710686002286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686002287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686002288 active site 710686002289 metal binding site [ion binding]; metal-binding site 710686002290 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710686002291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686002292 active site 710686002293 motif I; other site 710686002294 motif II; other site 710686002295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686002296 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 710686002297 active site pocket [active] 710686002298 oxyanion hole [active] 710686002299 catalytic triad [active] 710686002300 active site nucleophile [active] 710686002301 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 710686002302 putative hydrophobic ligand binding site [chemical binding]; other site 710686002303 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 710686002304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686002305 ATP binding site [chemical binding]; other site 710686002306 putative Mg++ binding site [ion binding]; other site 710686002307 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 710686002308 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710686002309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686002310 ABC transporter signature motif; other site 710686002311 Walker B; other site 710686002312 D-loop; other site 710686002313 H-loop/switch region; other site 710686002314 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710686002315 Cupin domain; Region: Cupin_2; pfam07883 710686002316 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686002317 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 710686002318 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 710686002319 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710686002320 hypothetical protein; Provisional; Region: PRK13685 710686002321 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710686002322 metal ion-dependent adhesion site (MIDAS); other site 710686002323 hypothetical protein; Provisional; Region: PRK13685 710686002324 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710686002325 metal ion-dependent adhesion site (MIDAS); other site 710686002326 short chain dehydrogenase; Provisional; Region: PRK06197 710686002327 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710686002328 putative NAD(P) binding site [chemical binding]; other site 710686002329 active site 710686002330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002332 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710686002333 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710686002334 ring oligomerisation interface [polypeptide binding]; other site 710686002335 ATP/Mg binding site [chemical binding]; other site 710686002336 stacking interactions; other site 710686002337 hinge regions; other site 710686002338 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686002339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002340 S-adenosylmethionine binding site [chemical binding]; other site 710686002341 Phosphoesterase family; Region: Phosphoesterase; pfam04185 710686002342 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710686002343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686002344 active site 710686002345 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686002346 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 710686002347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686002348 O-methyltransferase; Region: Methyltransf_2; pfam00891 710686002349 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710686002350 DinB superfamily; Region: DinB_2; pfam12867 710686002351 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710686002352 active site 710686002353 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686002354 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 710686002355 NAD(P) binding site [chemical binding]; other site 710686002356 catalytic residues [active] 710686002357 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 710686002358 enoyl-CoA hydratase; Provisional; Region: PRK12478 710686002359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686002360 substrate binding site [chemical binding]; other site 710686002361 oxyanion hole (OAH) forming residues; other site 710686002362 trimer interface [polypeptide binding]; other site 710686002363 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 710686002364 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686002365 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 710686002366 putative hydrophobic ligand binding site [chemical binding]; other site 710686002367 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710686002368 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 710686002369 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710686002370 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710686002371 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710686002372 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710686002373 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710686002374 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710686002375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710686002376 metal ion-dependent adhesion site (MIDAS); other site 710686002377 MoxR-like ATPases [General function prediction only]; Region: COG0714 710686002378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686002379 Walker A motif; other site 710686002380 ATP binding site [chemical binding]; other site 710686002381 Walker B motif; other site 710686002382 arginine finger; other site 710686002383 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 710686002384 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 710686002385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686002386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686002387 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710686002388 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686002389 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686002390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686002391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686002392 non-specific DNA binding site [nucleotide binding]; other site 710686002393 salt bridge; other site 710686002394 sequence-specific DNA binding site [nucleotide binding]; other site 710686002395 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 710686002396 Domain of unknown function (DUF955); Region: DUF955; pfam06114 710686002397 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 710686002398 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686002399 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 710686002400 active site 2 [active] 710686002401 active site 1 [active] 710686002402 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686002403 active site 2 [active] 710686002404 isocitrate lyase; Provisional; Region: PRK15063 710686002405 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710686002406 tetramer interface [polypeptide binding]; other site 710686002407 active site 710686002408 Mg2+/Mn2+ binding site [ion binding]; other site 710686002409 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 710686002410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686002411 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710686002412 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710686002413 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 710686002414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002416 Predicted membrane protein [Function unknown]; Region: COG2733 710686002417 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686002418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686002419 non-specific DNA binding site [nucleotide binding]; other site 710686002420 salt bridge; other site 710686002421 sequence-specific DNA binding site [nucleotide binding]; other site 710686002422 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 710686002423 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 710686002424 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 710686002425 intersubunit interface [polypeptide binding]; other site 710686002426 active site 710686002427 catalytic residue [active] 710686002428 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710686002429 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710686002430 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 710686002431 putative active site [active] 710686002432 catalytic triad [active] 710686002433 putative dimer interface [polypeptide binding]; other site 710686002434 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710686002435 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710686002436 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 710686002437 FAD binding domain; Region: FAD_binding_4; pfam01565 710686002438 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 710686002439 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710686002440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686002441 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710686002442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686002443 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710686002444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686002445 NAD(P) binding site [chemical binding]; other site 710686002446 active site 710686002447 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710686002448 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 710686002449 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 710686002450 putative ADP-binding pocket [chemical binding]; other site 710686002451 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 710686002452 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686002453 catalytic core [active] 710686002454 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686002455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686002456 dimer interface [polypeptide binding]; other site 710686002457 phosphorylation site [posttranslational modification] 710686002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686002459 ATP binding site [chemical binding]; other site 710686002460 Mg2+ binding site [ion binding]; other site 710686002461 G-X-G motif; other site 710686002462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686002463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686002464 active site 710686002465 phosphorylation site [posttranslational modification] 710686002466 intermolecular recognition site; other site 710686002467 dimerization interface [polypeptide binding]; other site 710686002468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686002469 DNA binding site [nucleotide binding] 710686002470 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 710686002471 YCII-related domain; Region: YCII; pfam03795 710686002472 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710686002473 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710686002474 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710686002475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710686002476 DNA interaction; other site 710686002477 Metal-binding active site; metal-binding site 710686002478 AP (apurinic/apyrimidinic) site pocket; other site 710686002479 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710686002480 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 710686002481 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 710686002482 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686002483 DNA binding domain, excisionase family; Region: excise; TIGR01764 710686002484 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686002485 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 710686002486 putative NAD(P) binding site [chemical binding]; other site 710686002487 active site 710686002488 putative substrate binding site [chemical binding]; other site 710686002489 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686002490 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710686002491 putative acyl-acceptor binding pocket; other site 710686002492 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686002493 active site 710686002494 catalytic site [active] 710686002495 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710686002496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710686002497 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 710686002498 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 710686002499 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 710686002500 tRNA; other site 710686002501 putative tRNA binding site [nucleotide binding]; other site 710686002502 putative NADP binding site [chemical binding]; other site 710686002503 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 710686002504 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 710686002505 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 710686002506 domain interfaces; other site 710686002507 active site 710686002508 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 710686002509 active site 710686002510 homodimer interface [polypeptide binding]; other site 710686002511 SAM binding site [chemical binding]; other site 710686002512 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 710686002513 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710686002514 active site 710686002515 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 710686002516 dimer interface [polypeptide binding]; other site 710686002517 active site 710686002518 Schiff base residues; other site 710686002519 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710686002520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002522 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 710686002523 Cytochrome P450; Region: p450; cl12078 710686002524 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686002525 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686002526 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 710686002527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686002528 inhibitor-cofactor binding pocket; inhibition site 710686002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686002530 catalytic residue [active] 710686002531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686002532 catalytic core [active] 710686002533 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710686002534 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686002535 catalytic residues [active] 710686002536 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710686002537 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710686002538 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 710686002539 ResB-like family; Region: ResB; pfam05140 710686002540 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710686002541 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710686002542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686002543 P-loop; other site 710686002544 Magnesium ion binding site [ion binding]; other site 710686002545 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 710686002546 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710686002547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686002548 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 710686002549 amphipathic channel; other site 710686002550 Asn-Pro-Ala signature motifs; other site 710686002551 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 710686002552 heme binding pocket [chemical binding]; other site 710686002553 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 710686002554 Predicted membrane protein [Function unknown]; Region: COG4280 710686002555 PAS domain S-box; Region: sensory_box; TIGR00229 710686002556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686002557 putative active site [active] 710686002558 heme pocket [chemical binding]; other site 710686002559 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686002560 GAF domain; Region: GAF_3; pfam13492 710686002561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686002562 GAF domain; Region: GAF; pfam01590 710686002563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686002564 Histidine kinase; Region: HisKA_3; pfam07730 710686002565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686002566 ATP binding site [chemical binding]; other site 710686002567 Mg2+ binding site [ion binding]; other site 710686002568 G-X-G motif; other site 710686002569 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686002570 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710686002571 Histidine kinase; Region: HisKA_3; pfam07730 710686002572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686002573 ATP binding site [chemical binding]; other site 710686002574 Mg2+ binding site [ion binding]; other site 710686002575 G-X-G motif; other site 710686002576 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 710686002577 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710686002578 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 710686002579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686002580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686002581 active site 710686002582 catalytic tetrad [active] 710686002583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686002584 Response regulator receiver domain; Region: Response_reg; pfam00072 710686002585 active site 710686002586 phosphorylation site [posttranslational modification] 710686002587 intermolecular recognition site; other site 710686002588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686002589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686002590 active site 710686002591 phosphorylation site [posttranslational modification] 710686002592 intermolecular recognition site; other site 710686002593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686002594 DNA binding residues [nucleotide binding] 710686002595 dimerization interface [polypeptide binding]; other site 710686002596 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 710686002597 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 710686002598 putative ligand binding site [chemical binding]; other site 710686002599 NAD binding site [chemical binding]; other site 710686002600 catalytic site [active] 710686002601 Cupin domain; Region: Cupin_2; cl17218 710686002602 Cupin domain; Region: Cupin_2; cl17218 710686002603 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 710686002604 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 710686002605 putative molybdopterin cofactor binding site [chemical binding]; other site 710686002606 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 710686002607 putative molybdopterin cofactor binding site; other site 710686002608 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 710686002609 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 710686002610 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686002611 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686002612 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686002613 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686002614 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686002615 ligand binding site [chemical binding]; other site 710686002616 flexible hinge region; other site 710686002617 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710686002618 non-specific DNA interactions [nucleotide binding]; other site 710686002619 DNA binding site [nucleotide binding] 710686002620 sequence specific DNA binding site [nucleotide binding]; other site 710686002621 putative cAMP binding site [chemical binding]; other site 710686002622 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710686002623 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 710686002624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686002626 putative substrate translocation pore; other site 710686002627 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686002628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002629 S-adenosylmethionine binding site [chemical binding]; other site 710686002630 FAD binding domain; Region: FAD_binding_3; pfam01494 710686002631 hypothetical protein; Provisional; Region: PRK07236 710686002632 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710686002633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002634 acyl-activating enzyme (AAE) consensus motif; other site 710686002635 AMP binding site [chemical binding]; other site 710686002636 active site 710686002637 CoA binding site [chemical binding]; other site 710686002638 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686002639 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710686002640 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 710686002641 putative NAD(P) binding site [chemical binding]; other site 710686002642 active site 710686002643 putative substrate binding site [chemical binding]; other site 710686002644 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710686002645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002646 S-adenosylmethionine binding site [chemical binding]; other site 710686002647 YceI-like domain; Region: YceI; pfam04264 710686002648 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710686002649 Ferritin-like domain; Region: Ferritin; pfam00210 710686002650 dimerization interface [polypeptide binding]; other site 710686002651 DPS ferroxidase diiron center [ion binding]; other site 710686002652 ion pore; other site 710686002653 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686002654 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686002655 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686002656 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686002657 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686002658 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686002659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002661 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710686002662 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686002663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002664 S-adenosylmethionine binding site [chemical binding]; other site 710686002665 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710686002666 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686002667 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 710686002668 protein binding site [polypeptide binding]; other site 710686002669 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 710686002670 UbiA prenyltransferase family; Region: UbiA; pfam01040 710686002671 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 710686002672 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686002673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686002674 NAD(P) binding site [chemical binding]; other site 710686002675 active site 710686002676 Nitronate monooxygenase; Region: NMO; pfam03060 710686002677 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686002678 FMN binding site [chemical binding]; other site 710686002679 substrate binding site [chemical binding]; other site 710686002680 putative catalytic residue [active] 710686002681 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686002682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686002683 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686002684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686002685 dimer interface [polypeptide binding]; other site 710686002686 phosphorylation site [posttranslational modification] 710686002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686002688 ATP binding site [chemical binding]; other site 710686002689 Mg2+ binding site [ion binding]; other site 710686002690 G-X-G motif; other site 710686002691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686002692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686002693 active site 710686002694 phosphorylation site [posttranslational modification] 710686002695 intermolecular recognition site; other site 710686002696 dimerization interface [polypeptide binding]; other site 710686002697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686002698 DNA binding site [nucleotide binding] 710686002699 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686002700 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710686002701 Ligand binding site; other site 710686002702 Putative Catalytic site; other site 710686002703 DXD motif; other site 710686002704 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 710686002705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002706 S-adenosylmethionine binding site [chemical binding]; other site 710686002707 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710686002708 Moco binding site; other site 710686002709 metal coordination site [ion binding]; other site 710686002710 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686002711 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 710686002712 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710686002713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686002714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686002715 DNA binding residues [nucleotide binding] 710686002716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002718 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 710686002719 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 710686002720 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002721 active site 710686002722 CoA binding site [chemical binding]; other site 710686002723 AMP binding site [chemical binding]; other site 710686002724 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710686002725 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 710686002726 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710686002727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686002728 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686002729 active site 710686002730 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686002731 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002732 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686002733 acyl-activating enzyme (AAE) consensus motif; other site 710686002734 acyl-activating enzyme (AAE) consensus motif; other site 710686002735 putative AMP binding site [chemical binding]; other site 710686002736 putative active site [active] 710686002737 putative CoA binding site [chemical binding]; other site 710686002738 CoA binding site [chemical binding]; other site 710686002739 short chain dehydrogenase; Provisional; Region: PRK05866 710686002740 classical (c) SDRs; Region: SDR_c; cd05233 710686002741 NAD(P) binding site [chemical binding]; other site 710686002742 active site 710686002743 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710686002744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686002745 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710686002746 substrate binding site [chemical binding]; other site 710686002747 oxyanion hole (OAH) forming residues; other site 710686002748 trimer interface [polypeptide binding]; other site 710686002749 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686002750 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710686002751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686002752 motif II; other site 710686002753 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710686002754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686002755 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686002756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686002757 substrate binding site [chemical binding]; other site 710686002758 oxyanion hole (OAH) forming residues; other site 710686002759 trimer interface [polypeptide binding]; other site 710686002760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686002761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002762 acyl-CoA synthetase; Validated; Region: PRK06188 710686002763 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686002764 putative active site [active] 710686002765 putative CoA binding site [chemical binding]; other site 710686002766 putative AMP binding site [chemical binding]; other site 710686002767 YCII-related domain; Region: YCII; cl00999 710686002768 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710686002769 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710686002770 active site 710686002771 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686002772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002773 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686002774 acyl-activating enzyme (AAE) consensus motif; other site 710686002775 acyl-activating enzyme (AAE) consensus motif; other site 710686002776 putative AMP binding site [chemical binding]; other site 710686002777 putative active site [active] 710686002778 putative CoA binding site [chemical binding]; other site 710686002779 O-succinylbenzoate synthase; Provisional; Region: PRK02901 710686002780 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 710686002781 active site 710686002782 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686002783 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686002784 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710686002785 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686002786 conserved cys residue [active] 710686002787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686002788 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 710686002789 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710686002790 conserved cys residue [active] 710686002791 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686002792 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710686002793 putative active site [active] 710686002794 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686002795 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686002796 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 710686002797 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 710686002798 Na binding site [ion binding]; other site 710686002799 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 710686002800 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 710686002801 dimer interface [polypeptide binding]; other site 710686002802 tetramer interface [polypeptide binding]; other site 710686002803 PYR/PP interface [polypeptide binding]; other site 710686002804 TPP binding site [chemical binding]; other site 710686002805 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 710686002806 TPP-binding site; other site 710686002807 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 710686002808 Thioredoxin; Region: Thioredoxin_4; cl17273 710686002809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686002810 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710686002811 short chain dehydrogenase; Provisional; Region: PRK08263 710686002812 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686002813 NADP binding site [chemical binding]; other site 710686002814 active site 710686002815 steroid binding site; other site 710686002816 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 710686002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002818 S-adenosylmethionine binding site [chemical binding]; other site 710686002819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686002820 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710686002821 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710686002822 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710686002823 Protein of unknown function, DUF488; Region: DUF488; pfam04343 710686002824 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686002825 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686002826 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710686002827 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686002828 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710686002829 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710686002830 substrate binding pocket [chemical binding]; other site 710686002831 chain length determination region; other site 710686002832 substrate-Mg2+ binding site; other site 710686002833 catalytic residues [active] 710686002834 aspartate-rich region 1; other site 710686002835 active site lid residues [active] 710686002836 aspartate-rich region 2; other site 710686002837 heat shock protein HtpX; Provisional; Region: PRK03072 710686002838 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 710686002839 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710686002840 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710686002841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 710686002842 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 710686002843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710686002844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710686002845 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710686002846 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 710686002847 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 710686002848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686002849 sequence-specific DNA binding site [nucleotide binding]; other site 710686002850 salt bridge; other site 710686002851 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686002852 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686002853 cyclase homology domain; Region: CHD; cd07302 710686002854 nucleotidyl binding site; other site 710686002855 metal binding site [ion binding]; metal-binding site 710686002856 dimer interface [polypeptide binding]; other site 710686002857 PAS fold; Region: PAS_3; pfam08447 710686002858 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686002859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686002860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686002861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686002862 DNA binding residues [nucleotide binding] 710686002863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686002864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002865 S-adenosylmethionine binding site [chemical binding]; other site 710686002866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686002867 dimerization interface [polypeptide binding]; other site 710686002868 putative DNA binding site [nucleotide binding]; other site 710686002869 putative Zn2+ binding site [ion binding]; other site 710686002870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 710686002871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686002872 putative metal binding site [ion binding]; other site 710686002873 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 710686002874 amphipathic channel; other site 710686002875 Asn-Pro-Ala signature motifs; other site 710686002876 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710686002877 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710686002878 active site 710686002879 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710686002880 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686002881 FAD binding domain; Region: FAD_binding_4; pfam01565 710686002882 Berberine and berberine like; Region: BBE; pfam08031 710686002883 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686002884 classical (c) SDRs; Region: SDR_c; cd05233 710686002885 NAD(P) binding site [chemical binding]; other site 710686002886 active site 710686002887 acyl-CoA synthetase; Provisional; Region: PRK13383 710686002888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002889 acyl-activating enzyme (AAE) consensus motif; other site 710686002890 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686002891 AMP binding site [chemical binding]; other site 710686002892 active site 710686002893 acyl-activating enzyme (AAE) consensus motif; other site 710686002894 CoA binding site [chemical binding]; other site 710686002895 Cutinase; Region: Cutinase; pfam01083 710686002896 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 710686002897 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686002898 Cytochrome P450; Region: p450; cl12078 710686002899 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710686002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 710686002901 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 710686002902 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 710686002903 malonyl-CoA binding site [chemical binding]; other site 710686002904 dimer interface [polypeptide binding]; other site 710686002905 active site 710686002906 product binding site; other site 710686002907 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686002908 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686002909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686002910 active site 710686002911 ATP binding site [chemical binding]; other site 710686002912 substrate binding site [chemical binding]; other site 710686002913 activation loop (A-loop); other site 710686002914 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 710686002915 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 710686002916 putative ligand binding site [chemical binding]; other site 710686002917 NAD binding site [chemical binding]; other site 710686002918 catalytic site [active] 710686002919 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710686002920 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710686002921 dimer interface [polypeptide binding]; other site 710686002922 active site 710686002923 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686002924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002925 S-adenosylmethionine binding site [chemical binding]; other site 710686002926 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686002928 S-adenosylmethionine binding site [chemical binding]; other site 710686002929 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 710686002930 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686002931 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686002932 ligand binding site [chemical binding]; other site 710686002933 flexible hinge region; other site 710686002934 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686002935 hydrophobic ligand binding site; other site 710686002936 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710686002937 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686002938 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686002939 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 710686002940 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686002941 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686002942 active site 710686002943 ATP binding site [chemical binding]; other site 710686002944 substrate binding site [chemical binding]; other site 710686002945 activation loop (A-loop); other site 710686002946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686002947 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686002948 substrate binding pocket [chemical binding]; other site 710686002949 membrane-bound complex binding site; other site 710686002950 hinge residues; other site 710686002951 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710686002952 DNA-binding site [nucleotide binding]; DNA binding site 710686002953 RNA-binding motif; other site 710686002954 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710686002955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686002956 ATP binding site [chemical binding]; other site 710686002957 putative Mg++ binding site [ion binding]; other site 710686002958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686002959 nucleotide binding region [chemical binding]; other site 710686002960 ATP-binding site [chemical binding]; other site 710686002961 hypothetical protein; Provisional; Region: PRK06771 710686002962 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710686002963 Septum formation; Region: Septum_form; pfam13845 710686002964 Septum formation; Region: Septum_form; pfam13845 710686002965 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686002966 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710686002967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686002968 active site 710686002969 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686002970 Cytochrome P450; Region: p450; cl12078 710686002971 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686002972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686002973 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686002974 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 710686002975 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710686002976 DNA-binding site [nucleotide binding]; DNA binding site 710686002977 RNA-binding motif; other site 710686002978 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 710686002979 30S subunit binding site; other site 710686002980 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 710686002981 alanine dehydrogenase; Region: alaDH; TIGR00518 710686002982 putative active site [active] 710686002983 putative ligand binding site [chemical binding]; other site 710686002984 putative NAD(P) binding site [chemical binding]; other site 710686002985 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710686002986 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 710686002987 putative di-iron ligands [ion binding]; other site 710686002988 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710686002989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686002990 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686002991 hypothetical protein; Provisional; Region: PRK06541 710686002992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686002993 inhibitor-cofactor binding pocket; inhibition site 710686002994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686002995 catalytic residue [active] 710686002996 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686002997 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 710686002998 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 710686002999 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686003000 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 710686003001 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686003002 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710686003003 classical (c) SDRs; Region: SDR_c; cd05233 710686003004 NAD(P) binding site [chemical binding]; other site 710686003005 active site 710686003006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686003007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003008 NAD(P) binding site [chemical binding]; other site 710686003009 active site 710686003010 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 710686003011 agmatinase; Region: agmatinase; TIGR01230 710686003012 oligomer interface [polypeptide binding]; other site 710686003013 putative active site [active] 710686003014 Mn binding site [ion binding]; other site 710686003015 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 710686003016 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 710686003017 active site 710686003018 catalytic site [active] 710686003019 Zn binding site [ion binding]; other site 710686003020 tetramer interface [polypeptide binding]; other site 710686003021 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686003022 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686003023 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 710686003024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686003026 putative substrate translocation pore; other site 710686003027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686003028 Ligand Binding Site [chemical binding]; other site 710686003029 SOUL heme-binding protein; Region: SOUL; pfam04832 710686003030 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686003031 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710686003032 NodB motif; other site 710686003033 active site 710686003034 catalytic site [active] 710686003035 metal binding site [ion binding]; metal-binding site 710686003036 MMPL family; Region: MMPL; pfam03176 710686003037 MMPL family; Region: MMPL; pfam03176 710686003038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 710686003039 P-loop containing region of AAA domain; Region: AAA_29; cl17516 710686003040 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 710686003041 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686003042 NHL repeat; Region: NHL; pfam01436 710686003043 NHL repeat; Region: NHL; pfam01436 710686003044 NHL repeat; Region: NHL; pfam01436 710686003045 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686003046 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 710686003047 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710686003048 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686003049 Amino acid permease; Region: AA_permease_2; pfam13520 710686003050 threonine dehydratase; Provisional; Region: PRK08198 710686003051 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710686003052 tetramer interface [polypeptide binding]; other site 710686003053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686003054 catalytic residue [active] 710686003055 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 710686003056 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686003057 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686003058 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 710686003059 NAD binding site [chemical binding]; other site 710686003060 substrate binding site [chemical binding]; other site 710686003061 catalytic Zn binding site [ion binding]; other site 710686003062 structural Zn binding site [ion binding]; other site 710686003063 Domain of unknown function DUF59; Region: DUF59; pfam01883 710686003064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 710686003065 active site 710686003066 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686003067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003068 NAD(P) binding site [chemical binding]; other site 710686003069 active site 710686003070 hypothetical protein; Validated; Region: PRK07581 710686003071 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 710686003072 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 710686003073 Uncharacterized conserved protein [Function unknown]; Region: COG1656 710686003074 Protein of unknown function DUF82; Region: DUF82; pfam01927 710686003075 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686003076 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 710686003077 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 710686003078 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710686003079 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 710686003080 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710686003081 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 710686003082 DXD motif; other site 710686003083 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710686003084 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 710686003085 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 710686003086 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 710686003087 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710686003088 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 710686003089 primary dimer interface [polypeptide binding]; other site 710686003090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686003091 Coenzyme A binding pocket [chemical binding]; other site 710686003092 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 710686003093 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 710686003094 Thioredoxin; Region: Thioredoxin_4; cl17273 710686003095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003096 putative substrate translocation pore; other site 710686003097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003098 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686003099 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686003100 active site 710686003101 TDP-binding site; other site 710686003102 acceptor substrate-binding pocket; other site 710686003103 MAEBL; Provisional; Region: PTZ00121 710686003104 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686003105 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710686003106 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686003107 conserved cys residue [active] 710686003108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686003109 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 710686003110 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 710686003111 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710686003112 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 710686003113 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710686003114 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 710686003115 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 710686003116 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 710686003117 putative active site [active] 710686003118 homotetrameric interface [polypeptide binding]; other site 710686003119 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710686003120 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710686003121 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 710686003122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686003123 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686003124 GAF domain; Region: GAF; cl17456 710686003125 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686003126 GAF domain; Region: GAF; pfam01590 710686003127 GAF domain; Region: GAF_2; pfam13185 710686003128 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686003129 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710686003130 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686003131 acyl-activating enzyme (AAE) consensus motif; other site 710686003132 active site 710686003133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003134 metabolite-proton symporter; Region: 2A0106; TIGR00883 710686003135 putative substrate translocation pore; other site 710686003136 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710686003137 active site 710686003138 dimer interface [polypeptide binding]; other site 710686003139 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 710686003140 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710686003141 Ligand Binding Site [chemical binding]; other site 710686003142 Molecular Tunnel; other site 710686003143 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710686003144 RibD C-terminal domain; Region: RibD_C; cl17279 710686003145 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710686003146 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 710686003147 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 710686003148 G1 box; other site 710686003149 putative GEF interaction site [polypeptide binding]; other site 710686003150 GTP/Mg2+ binding site [chemical binding]; other site 710686003151 Switch I region; other site 710686003152 G2 box; other site 710686003153 G3 box; other site 710686003154 Switch II region; other site 710686003155 G4 box; other site 710686003156 G5 box; other site 710686003157 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710686003158 hypothetical protein; Provisional; Region: PRK07475 710686003159 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 710686003160 putative hydrophobic ligand binding site [chemical binding]; other site 710686003161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686003162 dimerization interface [polypeptide binding]; other site 710686003163 putative DNA binding site [nucleotide binding]; other site 710686003164 putative Zn2+ binding site [ion binding]; other site 710686003165 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686003166 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686003167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003168 putative substrate translocation pore; other site 710686003169 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 710686003170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003171 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 710686003172 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710686003173 active site 710686003174 FMN binding site [chemical binding]; other site 710686003175 substrate binding site [chemical binding]; other site 710686003176 3Fe-4S cluster binding site [ion binding]; other site 710686003177 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 710686003178 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 710686003179 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686003180 PIF1-like helicase; Region: PIF1; pfam05970 710686003181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686003182 Walker A motif; other site 710686003183 ATP binding site [chemical binding]; other site 710686003184 Walker B motif; other site 710686003185 Helicase; Region: Herpes_Helicase; pfam02689 710686003186 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 710686003187 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710686003188 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710686003189 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710686003190 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710686003191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686003192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686003193 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 710686003194 AAA domain; Region: AAA_30; pfam13604 710686003195 Family description; Region: UvrD_C_2; pfam13538 710686003196 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 710686003197 Part of AAA domain; Region: AAA_19; pfam13245 710686003198 Family description; Region: UvrD_C_2; pfam13538 710686003199 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 710686003200 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 710686003201 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 710686003202 HD domain; Region: HD_4; pfam13328 710686003203 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710686003204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710686003205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686003206 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 710686003207 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 710686003208 oligomer interface [polypeptide binding]; other site 710686003209 metal binding site [ion binding]; metal-binding site 710686003210 metal binding site [ion binding]; metal-binding site 710686003211 putative Cl binding site [ion binding]; other site 710686003212 aspartate ring; other site 710686003213 basic sphincter; other site 710686003214 hydrophobic gate; other site 710686003215 periplasmic entrance; other site 710686003216 Phospholipid methyltransferase; Region: PEMT; cl17370 710686003217 HD domain; Region: HD_5; pfam13487 710686003218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686003219 Zn2+ binding site [ion binding]; other site 710686003220 Mg2+ binding site [ion binding]; other site 710686003221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686003222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686003223 DNA binding residues [nucleotide binding] 710686003224 dimerization interface [polypeptide binding]; other site 710686003225 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686003226 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686003227 active site 710686003228 ATP binding site [chemical binding]; other site 710686003229 substrate binding site [chemical binding]; other site 710686003230 activation loop (A-loop); other site 710686003231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686003232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003233 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686003234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686003235 substrate binding site [chemical binding]; other site 710686003236 oxyanion hole (OAH) forming residues; other site 710686003237 trimer interface [polypeptide binding]; other site 710686003238 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 710686003239 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 710686003240 active site 710686003241 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710686003242 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 710686003243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710686003244 LabA_like proteins; Region: LabA_like; cd06167 710686003245 putative metal binding site [ion binding]; other site 710686003246 Uncharacterized conserved protein [Function unknown]; Region: COG1432 710686003247 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 710686003248 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710686003249 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686003250 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 710686003251 active site 710686003252 catalytic site [active] 710686003253 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686003254 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 710686003255 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 710686003256 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710686003257 putative homodimer interface [polypeptide binding]; other site 710686003258 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 710686003259 heterodimer interface [polypeptide binding]; other site 710686003260 homodimer interface [polypeptide binding]; other site 710686003261 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710686003262 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710686003263 23S rRNA interface [nucleotide binding]; other site 710686003264 L7/L12 interface [polypeptide binding]; other site 710686003265 putative thiostrepton binding site; other site 710686003266 L25 interface [polypeptide binding]; other site 710686003267 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 710686003268 mRNA/rRNA interface [nucleotide binding]; other site 710686003269 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710686003270 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710686003271 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 710686003272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686003273 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 710686003274 putative ADP-binding pocket [chemical binding]; other site 710686003275 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686003276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686003277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686003278 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710686003279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003280 S-adenosylmethionine binding site [chemical binding]; other site 710686003281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 710686003282 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710686003283 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710686003284 active site 710686003285 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 710686003286 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710686003287 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 710686003288 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686003289 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686003290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686003291 extended (e) SDRs; Region: SDR_e; cd08946 710686003292 NAD(P) binding site [chemical binding]; other site 710686003293 active site 710686003294 substrate binding site [chemical binding]; other site 710686003295 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710686003296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710686003297 active site 710686003298 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710686003299 Chain length determinant protein; Region: Wzz; cl15801 710686003300 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 710686003301 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686003302 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 710686003303 AAA ATPase domain; Region: AAA_16; pfam13191 710686003304 AAA domain; Region: AAA_22; pfam13401 710686003305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686003306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686003307 DNA binding residues [nucleotide binding] 710686003308 dimerization interface [polypeptide binding]; other site 710686003309 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710686003310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686003311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686003312 DNA binding residues [nucleotide binding] 710686003313 YCII-related domain; Region: YCII; cl00999 710686003314 YCII-related domain; Region: YCII; cl00999 710686003315 PE-PPE domain; Region: PE-PPE; pfam08237 710686003316 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686003317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003318 S-adenosylmethionine binding site [chemical binding]; other site 710686003319 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686003320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686003321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003322 S-adenosylmethionine binding site [chemical binding]; other site 710686003323 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686003324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003325 S-adenosylmethionine binding site [chemical binding]; other site 710686003326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686003327 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710686003328 ABC1 family; Region: ABC1; cl17513 710686003329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686003330 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686003331 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686003332 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710686003333 DinB superfamily; Region: DinB_2; pfam12867 710686003334 DinB superfamily; Region: DinB_2; pfam12867 710686003335 Predicted transcriptional regulator [Transcription]; Region: COG2378 710686003336 HTH domain; Region: HTH_11; pfam08279 710686003337 WYL domain; Region: WYL; pfam13280 710686003338 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710686003339 putative catalytic site [active] 710686003340 putative metal binding site [ion binding]; other site 710686003341 putative phosphate binding site [ion binding]; other site 710686003342 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 710686003343 active site 710686003344 catalytic site [active] 710686003345 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 710686003346 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 710686003347 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 710686003348 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710686003349 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710686003350 nucleotide binding site [chemical binding]; other site 710686003351 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 710686003352 23S rRNA interface [nucleotide binding]; other site 710686003353 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710686003354 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710686003355 core dimer interface [polypeptide binding]; other site 710686003356 peripheral dimer interface [polypeptide binding]; other site 710686003357 L10 interface [polypeptide binding]; other site 710686003358 L11 interface [polypeptide binding]; other site 710686003359 putative EF-Tu interaction site [polypeptide binding]; other site 710686003360 putative EF-G interaction site [polypeptide binding]; other site 710686003361 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 710686003362 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 710686003363 Walker A/P-loop; other site 710686003364 ATP binding site [chemical binding]; other site 710686003365 Q-loop/lid; other site 710686003366 ABC transporter signature motif; other site 710686003367 Walker B; other site 710686003368 D-loop; other site 710686003369 H-loop/switch region; other site 710686003370 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686003371 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686003372 molybdopterin cofactor binding site; other site 710686003373 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686003374 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710686003375 molybdopterin cofactor binding site; other site 710686003376 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686003377 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686003378 active site 710686003379 ATP binding site [chemical binding]; other site 710686003380 substrate binding site [chemical binding]; other site 710686003381 activation loop (A-loop); other site 710686003382 AAA ATPase domain; Region: AAA_16; pfam13191 710686003383 AAA domain; Region: AAA_22; pfam13401 710686003384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710686003385 TPR motif; other site 710686003386 binding surface 710686003387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710686003388 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710686003389 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710686003390 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710686003391 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710686003392 RPB10 interaction site [polypeptide binding]; other site 710686003393 RPB1 interaction site [polypeptide binding]; other site 710686003394 RPB11 interaction site [polypeptide binding]; other site 710686003395 RPB3 interaction site [polypeptide binding]; other site 710686003396 RPB12 interaction site [polypeptide binding]; other site 710686003397 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710686003398 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 710686003399 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710686003400 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710686003401 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 710686003402 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 710686003403 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 710686003404 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710686003405 DNA binding site [nucleotide binding] 710686003406 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710686003407 endonuclease IV; Provisional; Region: PRK01060 710686003408 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 710686003409 AP (apurinic/apyrimidinic) site pocket; other site 710686003410 DNA interaction; other site 710686003411 Metal-binding active site; metal-binding site 710686003412 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710686003413 active site 710686003414 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 710686003415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686003416 active site 710686003417 enoyl-CoA hydratase; Provisional; Region: PRK12478 710686003418 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686003419 substrate binding site [chemical binding]; other site 710686003420 oxyanion hole (OAH) forming residues; other site 710686003421 trimer interface [polypeptide binding]; other site 710686003422 PaaX-like protein; Region: PaaX; pfam07848 710686003423 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 710686003424 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686003425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686003426 substrate binding site [chemical binding]; other site 710686003427 oxyanion hole (OAH) forming residues; other site 710686003428 trimer interface [polypeptide binding]; other site 710686003429 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710686003430 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710686003431 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710686003432 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710686003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003435 WHG domain; Region: WHG; pfam13305 710686003436 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710686003437 S17 interaction site [polypeptide binding]; other site 710686003438 S8 interaction site; other site 710686003439 16S rRNA interaction site [nucleotide binding]; other site 710686003440 streptomycin interaction site [chemical binding]; other site 710686003441 23S rRNA interaction site [nucleotide binding]; other site 710686003442 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710686003443 30S ribosomal protein S7; Validated; Region: PRK05302 710686003444 elongation factor G; Reviewed; Region: PRK00007 710686003445 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 710686003446 G1 box; other site 710686003447 putative GEF interaction site [polypeptide binding]; other site 710686003448 GTP/Mg2+ binding site [chemical binding]; other site 710686003449 Switch I region; other site 710686003450 G2 box; other site 710686003451 G3 box; other site 710686003452 Switch II region; other site 710686003453 G4 box; other site 710686003454 G5 box; other site 710686003455 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710686003456 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710686003457 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710686003458 elongation factor Tu; Reviewed; Region: PRK00049 710686003459 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 710686003460 G1 box; other site 710686003461 GEF interaction site [polypeptide binding]; other site 710686003462 GTP/Mg2+ binding site [chemical binding]; other site 710686003463 Switch I region; other site 710686003464 G2 box; other site 710686003465 G3 box; other site 710686003466 Switch II region; other site 710686003467 G4 box; other site 710686003468 G5 box; other site 710686003469 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710686003470 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 710686003471 Antibiotic Binding Site [chemical binding]; other site 710686003472 Cutinase; Region: Cutinase; pfam01083 710686003473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003474 putative substrate translocation pore; other site 710686003475 Short C-terminal domain; Region: SHOCT; pfam09851 710686003476 arginine deiminase; Provisional; Region: PRK01388 710686003477 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686003478 classical (c) SDRs; Region: SDR_c; cd05233 710686003479 NAD(P) binding site [chemical binding]; other site 710686003480 active site 710686003481 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686003482 Ligand Binding Site [chemical binding]; other site 710686003483 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686003484 Ligand Binding Site [chemical binding]; other site 710686003485 amino acid transporter; Region: 2A0306; TIGR00909 710686003486 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 710686003487 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 710686003488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686003489 inhibitor-cofactor binding pocket; inhibition site 710686003490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686003491 catalytic residue [active] 710686003492 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710686003493 Amidinotransferase; Region: Amidinotransf; pfam02274 710686003494 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710686003495 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 710686003496 putative DNA binding site [nucleotide binding]; other site 710686003497 putative Zn2+ binding site [ion binding]; other site 710686003498 AsnC family; Region: AsnC_trans_reg; pfam01037 710686003499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710686003500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686003501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710686003502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686003503 putative dimer interface [polypeptide binding]; other site 710686003504 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710686003505 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686003506 active site 710686003507 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710686003508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686003509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686003510 DNA binding residues [nucleotide binding] 710686003511 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710686003512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003513 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 710686003514 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 710686003515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686003516 FeS/SAM binding site; other site 710686003517 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710686003518 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 710686003519 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686003520 phosphate binding site [ion binding]; other site 710686003521 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 710686003522 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 710686003523 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 710686003524 active site 710686003525 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 710686003526 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686003528 putative substrate translocation pore; other site 710686003529 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710686003530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686003531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003532 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686003533 Cytochrome P450; Region: p450; cl12078 710686003534 Carboxylesterase family; Region: COesterase; pfam00135 710686003535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686003536 substrate binding pocket [chemical binding]; other site 710686003537 catalytic triad [active] 710686003538 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686003539 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 710686003540 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 710686003541 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 710686003542 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 710686003543 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710686003544 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710686003545 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710686003546 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 710686003547 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710686003548 putative translocon binding site; other site 710686003549 protein-rRNA interface [nucleotide binding]; other site 710686003550 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710686003551 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 710686003552 G-X-X-G motif; other site 710686003553 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710686003554 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710686003555 23S rRNA interface [nucleotide binding]; other site 710686003556 5S rRNA interface [nucleotide binding]; other site 710686003557 putative antibiotic binding site [chemical binding]; other site 710686003558 L25 interface [polypeptide binding]; other site 710686003559 L27 interface [polypeptide binding]; other site 710686003560 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 710686003561 putative translocon interaction site; other site 710686003562 23S rRNA interface [nucleotide binding]; other site 710686003563 signal recognition particle (SRP54) interaction site; other site 710686003564 L23 interface [polypeptide binding]; other site 710686003565 trigger factor interaction site; other site 710686003566 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 710686003567 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 710686003568 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710686003569 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710686003570 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686003571 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 710686003572 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710686003573 Sulfatase; Region: Sulfatase; pfam00884 710686003574 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710686003575 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710686003576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003577 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710686003578 NAD(P) binding site [chemical binding]; other site 710686003579 active site 710686003580 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 710686003581 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 710686003582 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 710686003583 RNA binding site [nucleotide binding]; other site 710686003584 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710686003585 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710686003586 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710686003587 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 710686003588 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 710686003589 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710686003590 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710686003591 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710686003592 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710686003593 5S rRNA interface [nucleotide binding]; other site 710686003594 L27 interface [polypeptide binding]; other site 710686003595 23S rRNA interface [nucleotide binding]; other site 710686003596 L5 interface [polypeptide binding]; other site 710686003597 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710686003598 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710686003599 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710686003600 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 710686003601 23S rRNA binding site [nucleotide binding]; other site 710686003602 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 710686003603 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686003604 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686003605 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686003606 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 710686003607 tandem repeat interface [polypeptide binding]; other site 710686003608 oligomer interface [polypeptide binding]; other site 710686003609 active site residues [active] 710686003610 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 710686003611 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 710686003612 tandem repeat interface [polypeptide binding]; other site 710686003613 oligomer interface [polypeptide binding]; other site 710686003614 active site residues [active] 710686003615 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686003616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003617 NAD(P) binding site [chemical binding]; other site 710686003618 active site 710686003619 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686003620 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686003621 NAD(P) binding site [chemical binding]; other site 710686003622 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686003623 cyclase homology domain; Region: CHD; cd07302 710686003624 nucleotidyl binding site; other site 710686003625 metal binding site [ion binding]; metal-binding site 710686003626 dimer interface [polypeptide binding]; other site 710686003627 Predicted ATPase [General function prediction only]; Region: COG3903 710686003628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686003629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686003630 DNA binding residues [nucleotide binding] 710686003631 dimerization interface [polypeptide binding]; other site 710686003632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003634 S-adenosylmethionine binding site [chemical binding]; other site 710686003635 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 710686003636 intersubunit interface [polypeptide binding]; other site 710686003637 active site 710686003638 Zn2+ binding site [ion binding]; other site 710686003639 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 710686003640 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 710686003641 NAD binding site [chemical binding]; other site 710686003642 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686003643 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710686003644 nucleotide binding site [chemical binding]; other site 710686003645 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686003646 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686003647 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686003648 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686003649 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686003650 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686003651 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686003652 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686003653 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710686003654 SecY translocase; Region: SecY; pfam00344 710686003655 adenylate kinase; Reviewed; Region: adk; PRK00279 710686003656 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710686003657 AMP-binding site [chemical binding]; other site 710686003658 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710686003659 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710686003660 active site 710686003661 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710686003662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686003663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686003664 DNA binding residues [nucleotide binding] 710686003665 Putative zinc-finger; Region: zf-HC2; pfam13490 710686003666 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710686003667 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686003668 PYR/PP interface [polypeptide binding]; other site 710686003669 dimer interface [polypeptide binding]; other site 710686003670 TPP binding site [chemical binding]; other site 710686003671 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686003672 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 710686003673 TPP-binding site [chemical binding]; other site 710686003674 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 710686003675 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710686003676 active site 710686003677 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 710686003678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686003679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686003680 homodimer interface [polypeptide binding]; other site 710686003681 catalytic residue [active] 710686003682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686003683 MarR family; Region: MarR; pfam01047 710686003684 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686003685 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710686003686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686003687 Histidine kinase; Region: HisKA_3; pfam07730 710686003688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686003689 ATP binding site [chemical binding]; other site 710686003690 Mg2+ binding site [ion binding]; other site 710686003691 G-X-G motif; other site 710686003692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686003694 active site 710686003695 phosphorylation site [posttranslational modification] 710686003696 intermolecular recognition site; other site 710686003697 dimerization interface [polypeptide binding]; other site 710686003698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686003699 DNA binding residues [nucleotide binding] 710686003700 dimerization interface [polypeptide binding]; other site 710686003701 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710686003702 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710686003703 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686003704 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686003705 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686003706 active site 710686003707 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686003708 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 710686003709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686003710 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 710686003711 substrate binding pocket [chemical binding]; other site 710686003712 FAD binding site [chemical binding]; other site 710686003713 catalytic base [active] 710686003714 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710686003715 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710686003716 tetrameric interface [polypeptide binding]; other site 710686003717 NAD binding site [chemical binding]; other site 710686003718 catalytic residues [active] 710686003719 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 710686003720 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 710686003721 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 710686003722 NAD binding site [chemical binding]; other site 710686003723 substrate binding site [chemical binding]; other site 710686003724 homodimer interface [polypeptide binding]; other site 710686003725 active site 710686003726 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686003727 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686003728 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686003729 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686003730 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686003731 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686003732 ligand binding site [chemical binding]; other site 710686003733 flexible hinge region; other site 710686003734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686003735 ATP binding site [chemical binding]; other site 710686003736 Mg2+ binding site [ion binding]; other site 710686003737 G-X-G motif; other site 710686003738 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710686003739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686003740 active site 710686003741 phosphorylation site [posttranslational modification] 710686003742 intermolecular recognition site; other site 710686003743 dimerization interface [polypeptide binding]; other site 710686003744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710686003745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686003746 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710686003747 rRNA binding site [nucleotide binding]; other site 710686003748 predicted 30S ribosome binding site; other site 710686003749 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 710686003750 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 710686003751 30S ribosomal protein S13; Region: bact_S13; TIGR03631 710686003752 30S ribosomal protein S11; Validated; Region: PRK05309 710686003753 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710686003754 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710686003755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710686003756 RNA binding surface [nucleotide binding]; other site 710686003757 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710686003758 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710686003759 alphaNTD homodimer interface [polypeptide binding]; other site 710686003760 alphaNTD - beta interaction site [polypeptide binding]; other site 710686003761 alphaNTD - beta' interaction site [polypeptide binding]; other site 710686003762 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 710686003763 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 710686003764 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710686003765 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 710686003766 dimerization interface 3.5A [polypeptide binding]; other site 710686003767 active site 710686003768 Cutinase; Region: Cutinase; pfam01083 710686003769 Cutinase; Region: Cutinase; pfam01083 710686003770 Cutinase; Region: Cutinase; pfam01083 710686003771 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 710686003772 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710686003773 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686003774 NAD(P) binding site [chemical binding]; other site 710686003775 catalytic residues [active] 710686003776 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686003777 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 710686003778 NAD binding site [chemical binding]; other site 710686003779 substrate binding site [chemical binding]; other site 710686003780 catalytic Zn binding site [ion binding]; other site 710686003781 tetramer interface [polypeptide binding]; other site 710686003782 structural Zn binding site [ion binding]; other site 710686003783 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710686003784 23S rRNA interface [nucleotide binding]; other site 710686003785 L3 interface [polypeptide binding]; other site 710686003786 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 710686003787 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 710686003788 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 710686003789 active site 710686003790 substrate binding site [chemical binding]; other site 710686003791 metal binding site [ion binding]; metal-binding site 710686003792 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 710686003793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686003794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710686003795 dimerization interface [polypeptide binding]; other site 710686003796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003797 short chain dehydrogenase; Provisional; Region: PRK07041 710686003798 NAD(P) binding site [chemical binding]; other site 710686003799 active site 710686003800 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710686003801 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686003802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710686003803 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710686003804 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710686003805 glutaminase active site [active] 710686003806 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710686003807 dimer interface [polypeptide binding]; other site 710686003808 active site 710686003809 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710686003810 dimer interface [polypeptide binding]; other site 710686003811 active site 710686003812 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 710686003813 CGNR zinc finger; Region: zf-CGNR; pfam11706 710686003814 Uncharacterized conserved protein [Function unknown]; Region: COG0062 710686003815 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 710686003816 putative substrate binding site [chemical binding]; other site 710686003817 putative ATP binding site [chemical binding]; other site 710686003818 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 710686003819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686003820 catalytic residue [active] 710686003821 alanine racemase; Reviewed; Region: alr; PRK00053 710686003822 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 710686003823 active site 710686003824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686003825 dimer interface [polypeptide binding]; other site 710686003826 substrate binding site [chemical binding]; other site 710686003827 catalytic residues [active] 710686003828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686003829 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686003830 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 710686003831 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 710686003832 Glycoprotease family; Region: Peptidase_M22; pfam00814 710686003833 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 710686003834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686003835 Coenzyme A binding pocket [chemical binding]; other site 710686003836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710686003837 UGMP family protein; Validated; Region: PRK09604 710686003838 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710686003839 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710686003840 oligomerisation interface [polypeptide binding]; other site 710686003841 mobile loop; other site 710686003842 roof hairpin; other site 710686003843 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710686003844 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710686003845 ring oligomerisation interface [polypeptide binding]; other site 710686003846 ATP/Mg binding site [chemical binding]; other site 710686003847 stacking interactions; other site 710686003848 hinge regions; other site 710686003849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686003850 dimerization interface [polypeptide binding]; other site 710686003851 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686003852 cyclase homology domain; Region: CHD; cd07302 710686003853 nucleotidyl binding site; other site 710686003854 metal binding site [ion binding]; metal-binding site 710686003855 dimer interface [polypeptide binding]; other site 710686003856 Uncharacterized conserved protein [Function unknown]; Region: COG2966 710686003857 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 710686003858 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 710686003859 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 710686003860 Transcription factor WhiB; Region: Whib; pfam02467 710686003861 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 710686003862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686003863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686003864 DNA binding residues [nucleotide binding] 710686003865 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 710686003866 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686003867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 710686003868 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710686003869 active site 710686003870 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 710686003871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686003872 phosphate binding site [ion binding]; other site 710686003873 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710686003874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686003875 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686003876 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710686003877 PhoU domain; Region: PhoU; pfam01895 710686003878 PhoU domain; Region: PhoU; pfam01895 710686003879 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710686003880 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710686003881 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710686003882 short chain dehydrogenase; Provisional; Region: PRK07856 710686003883 classical (c) SDRs; Region: SDR_c; cd05233 710686003884 NAD(P) binding site [chemical binding]; other site 710686003885 active site 710686003886 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686003887 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686003888 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 710686003889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003890 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710686003891 GMP synthase; Reviewed; Region: guaA; PRK00074 710686003892 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 710686003893 AMP/PPi binding site [chemical binding]; other site 710686003894 candidate oxyanion hole; other site 710686003895 catalytic triad [active] 710686003896 potential glutamine specificity residues [chemical binding]; other site 710686003897 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 710686003898 ATP Binding subdomain [chemical binding]; other site 710686003899 Ligand Binding sites [chemical binding]; other site 710686003900 Dimerization subdomain; other site 710686003901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686003902 WHG domain; Region: WHG; pfam13305 710686003903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686003904 NmrA-like family; Region: NmrA; pfam05368 710686003905 NAD(P) binding site [chemical binding]; other site 710686003906 active site 710686003907 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710686003908 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686003909 DNA binding residues [nucleotide binding] 710686003910 putative dimer interface [polypeptide binding]; other site 710686003911 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686003912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686003913 dinuclear metal binding motif [ion binding]; other site 710686003914 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686003915 classical (c) SDRs; Region: SDR_c; cd05233 710686003916 short chain dehydrogenase; Provisional; Region: PRK05650 710686003917 NAD(P) binding site [chemical binding]; other site 710686003918 active site 710686003919 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710686003920 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710686003921 DNA Polymerase Y-family; Region: PolY_like; cd03468 710686003922 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 710686003923 DNA binding site [nucleotide binding] 710686003924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686003925 MarR family; Region: MarR; pfam01047 710686003926 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 710686003927 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 710686003928 active site 710686003929 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710686003930 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 710686003931 FtsX-like permease family; Region: FtsX; pfam02687 710686003932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686003933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686003934 Walker A/P-loop; other site 710686003935 ATP binding site [chemical binding]; other site 710686003936 Q-loop/lid; other site 710686003937 ABC transporter signature motif; other site 710686003938 Walker B; other site 710686003939 D-loop; other site 710686003940 H-loop/switch region; other site 710686003941 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 710686003942 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 710686003943 malonyl-CoA binding site [chemical binding]; other site 710686003944 dimer interface [polypeptide binding]; other site 710686003945 active site 710686003946 product binding site; other site 710686003947 short chain dehydrogenase; Provisional; Region: PRK07201 710686003948 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 710686003949 putative NAD(P) binding site [chemical binding]; other site 710686003950 active site 710686003951 putative substrate binding site [chemical binding]; other site 710686003952 classical (c) SDRs; Region: SDR_c; cd05233 710686003953 NAD(P) binding site [chemical binding]; other site 710686003954 active site 710686003955 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686003956 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710686003957 dimer interaction site [polypeptide binding]; other site 710686003958 substrate-binding tunnel; other site 710686003959 active site 710686003960 catalytic site [active] 710686003961 substrate binding site [chemical binding]; other site 710686003962 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686003963 Ligand Binding Site [chemical binding]; other site 710686003964 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686003965 Ligand Binding Site [chemical binding]; other site 710686003966 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710686003967 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 710686003968 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710686003969 active site 710686003970 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710686003971 generic binding surface II; other site 710686003972 generic binding surface I; other site 710686003973 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710686003974 FMN binding site [chemical binding]; other site 710686003975 dimer interface [polypeptide binding]; other site 710686003976 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 710686003977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686003978 S-adenosylmethionine binding site [chemical binding]; other site 710686003979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686003980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686003981 ATP binding site [chemical binding]; other site 710686003982 Mg2+ binding site [ion binding]; other site 710686003983 G-X-G motif; other site 710686003984 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 710686003985 Protein of unknown function (DUF742); Region: DUF742; pfam05331 710686003986 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 710686003987 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 710686003988 G1 box; other site 710686003989 GTP/Mg2+ binding site [chemical binding]; other site 710686003990 G2 box; other site 710686003991 Switch I region; other site 710686003992 G3 box; other site 710686003993 Switch II region; other site 710686003994 G4 box; other site 710686003995 G5 box; other site 710686003996 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710686003997 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710686003998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710686003999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004001 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686004002 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 710686004003 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686004004 putative NAD(P) binding site [chemical binding]; other site 710686004005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686004006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686004007 active site 710686004008 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686004009 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686004010 phosphopeptide binding site; other site 710686004011 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686004012 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686004013 phosphopeptide binding site; other site 710686004014 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710686004015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686004016 Walker A/P-loop; other site 710686004017 ATP binding site [chemical binding]; other site 710686004018 Q-loop/lid; other site 710686004019 ABC transporter signature motif; other site 710686004020 Walker B; other site 710686004021 D-loop; other site 710686004022 H-loop/switch region; other site 710686004023 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686004024 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710686004025 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710686004026 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 710686004027 active site 710686004028 FMN binding site [chemical binding]; other site 710686004029 substrate binding site [chemical binding]; other site 710686004030 putative catalytic residue [active] 710686004031 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 710686004032 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710686004033 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 710686004034 homodimer interface [polypeptide binding]; other site 710686004035 NADP binding site [chemical binding]; other site 710686004036 substrate binding site [chemical binding]; other site 710686004037 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 710686004038 RibD C-terminal domain; Region: RibD_C; cl17279 710686004039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 710686004040 AAA domain; Region: AAA_33; pfam13671 710686004041 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 710686004042 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710686004043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686004045 S-adenosylmethionine binding site [chemical binding]; other site 710686004046 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 710686004047 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 710686004048 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 710686004049 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710686004050 homodimer interface [polypeptide binding]; other site 710686004051 substrate-cofactor binding pocket; other site 710686004052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686004053 catalytic residue [active] 710686004054 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 710686004055 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 710686004056 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686004057 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686004058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686004059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686004060 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 710686004061 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710686004062 active site 710686004063 HIGH motif; other site 710686004064 dimer interface [polypeptide binding]; other site 710686004065 KMSKS motif; other site 710686004066 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 710686004067 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710686004068 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710686004069 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 710686004070 Strictosidine synthase; Region: Str_synth; pfam03088 710686004071 hypothetical protein; Provisional; Region: PRK06541 710686004072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686004073 inhibitor-cofactor binding pocket; inhibition site 710686004074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686004075 catalytic residue [active] 710686004076 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710686004077 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710686004078 putative DNA binding site [nucleotide binding]; other site 710686004079 putative Zn2+ binding site [ion binding]; other site 710686004080 AsnC family; Region: AsnC_trans_reg; pfam01037 710686004081 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710686004082 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686004083 NAD(P) binding site [chemical binding]; other site 710686004084 catalytic residues [active] 710686004085 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686004086 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 710686004087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686004088 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710686004089 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686004090 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686004091 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710686004092 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 710686004093 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710686004094 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 710686004095 L-aspartate oxidase; Provisional; Region: PRK06175 710686004096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710686004097 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 710686004098 putative Iron-sulfur protein interface [polypeptide binding]; other site 710686004099 putative proximal heme binding site [chemical binding]; other site 710686004100 putative SdhC-like subunit interface [polypeptide binding]; other site 710686004101 putative distal heme binding site [chemical binding]; other site 710686004102 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 710686004103 putative Iron-sulfur protein interface [polypeptide binding]; other site 710686004104 putative proximal heme binding site [chemical binding]; other site 710686004105 putative SdhD-like interface [polypeptide binding]; other site 710686004106 putative distal heme binding site [chemical binding]; other site 710686004107 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710686004108 active site 710686004109 catalytic motif [active] 710686004110 Zn binding site [ion binding]; other site 710686004111 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 710686004112 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710686004113 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710686004114 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710686004115 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 710686004116 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 710686004117 adenosine deaminase; Provisional; Region: PRK09358 710686004118 active site 710686004119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686004120 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686004121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686004122 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710686004123 putative NAD(P) binding site [chemical binding]; other site 710686004124 short chain dehydrogenase; Validated; Region: PRK08264 710686004125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004126 NAD(P) binding site [chemical binding]; other site 710686004127 active site 710686004128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686004129 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686004130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004132 short chain dehydrogenase; Provisional; Region: PRK06180 710686004133 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686004134 NADP binding site [chemical binding]; other site 710686004135 active site 710686004136 steroid binding site; other site 710686004137 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 710686004138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004142 amidase; Provisional; Region: PRK06170 710686004143 Amidase; Region: Amidase; pfam01425 710686004144 short chain dehydrogenase; Provisional; Region: PRK05872 710686004145 classical (c) SDRs; Region: SDR_c; cd05233 710686004146 NAD(P) binding site [chemical binding]; other site 710686004147 active site 710686004148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004150 WHG domain; Region: WHG; pfam13305 710686004151 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686004152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686004153 substrate binding site [chemical binding]; other site 710686004154 oxyanion hole (OAH) forming residues; other site 710686004155 trimer interface [polypeptide binding]; other site 710686004156 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710686004157 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686004158 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710686004159 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686004160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686004161 acyl-activating enzyme (AAE) consensus motif; other site 710686004162 AMP binding site [chemical binding]; other site 710686004163 active site 710686004164 CoA binding site [chemical binding]; other site 710686004165 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710686004166 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 710686004167 putative active site [active] 710686004168 putative FMN binding site [chemical binding]; other site 710686004169 putative substrate binding site [chemical binding]; other site 710686004170 putative catalytic residue [active] 710686004171 classical (c) SDRs; Region: SDR_c; cd05233 710686004172 NAD(P) binding site [chemical binding]; other site 710686004173 active site 710686004174 Fe-S metabolism associated domain; Region: SufE; cl00951 710686004175 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 710686004176 GIY-YIG motif/motif A; other site 710686004177 active site 710686004178 catalytic site [active] 710686004179 metal binding site [ion binding]; metal-binding site 710686004180 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 710686004181 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 710686004182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686004183 ATP binding site [chemical binding]; other site 710686004184 putative Mg++ binding site [ion binding]; other site 710686004185 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710686004186 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 710686004187 HsdM N-terminal domain; Region: HsdM_N; pfam12161 710686004188 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 710686004189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686004190 S-adenosylmethionine binding site [chemical binding]; other site 710686004191 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 710686004192 GIY-YIG motif/motif A; other site 710686004193 putative active site [active] 710686004194 putative metal binding site [ion binding]; other site 710686004195 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686004196 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 710686004197 multiple promoter invertase; Provisional; Region: mpi; PRK13413 710686004198 catalytic residues [active] 710686004199 catalytic nucleophile [active] 710686004200 Presynaptic Site I dimer interface [polypeptide binding]; other site 710686004201 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 710686004202 Synaptic Flat tetramer interface [polypeptide binding]; other site 710686004203 Synaptic Site I dimer interface [polypeptide binding]; other site 710686004204 DNA binding site [nucleotide binding] 710686004205 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710686004206 DNA-binding interface [nucleotide binding]; DNA binding site 710686004207 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710686004208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686004211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686004212 active site 710686004213 ATP binding site [chemical binding]; other site 710686004214 substrate binding site [chemical binding]; other site 710686004215 activation loop (A-loop); other site 710686004216 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 710686004217 Helix-turn-helix domain; Region: HTH_17; cl17695 710686004218 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686004219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686004220 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686004221 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686004222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686004223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686004224 non-specific DNA binding site [nucleotide binding]; other site 710686004225 salt bridge; other site 710686004226 sequence-specific DNA binding site [nucleotide binding]; other site 710686004227 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 710686004228 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710686004229 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 710686004230 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710686004231 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 710686004232 catalytic residues [active] 710686004233 catalytic nucleophile [active] 710686004234 Recombinase; Region: Recombinase; pfam07508 710686004235 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 710686004236 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686004237 NlpC/P60 family; Region: NLPC_P60; cl17555 710686004238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686004239 active site 710686004240 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 710686004241 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 710686004242 active site 710686004243 substrate binding site [chemical binding]; other site 710686004244 metal binding site [ion binding]; metal-binding site 710686004245 MarR family; Region: MarR_2; pfam12802 710686004246 Putative ammonia monooxygenase; Region: AmoA; pfam05145 710686004247 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710686004248 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710686004249 purine nucleoside phosphorylase; Provisional; Region: PRK08202 710686004250 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 710686004251 amidohydrolase; Region: amidohydrolases; TIGR01891 710686004252 metal binding site [ion binding]; metal-binding site 710686004253 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710686004254 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 710686004255 metal binding site [ion binding]; metal-binding site 710686004256 putative dimer interface [polypeptide binding]; other site 710686004257 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686004258 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710686004259 putative active site pocket [active] 710686004260 dimerization interface [polypeptide binding]; other site 710686004261 putative catalytic residue [active] 710686004262 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 710686004263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686004264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686004265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686004266 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710686004267 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710686004268 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 710686004269 probable active site [active] 710686004270 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 710686004271 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 710686004272 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 710686004273 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710686004274 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004276 NAD(P) binding site [chemical binding]; other site 710686004277 active site 710686004278 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686004279 classical (c) SDRs; Region: SDR_c; cd05233 710686004280 NAD(P) binding site [chemical binding]; other site 710686004281 active site 710686004282 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686004283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686004284 substrate binding site [chemical binding]; other site 710686004285 oxyanion hole (OAH) forming residues; other site 710686004286 trimer interface [polypeptide binding]; other site 710686004287 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 710686004288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004289 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710686004290 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686004291 FAD binding pocket [chemical binding]; other site 710686004292 FAD binding motif [chemical binding]; other site 710686004293 phosphate binding motif [ion binding]; other site 710686004294 beta-alpha-beta structure motif; other site 710686004295 NAD binding pocket [chemical binding]; other site 710686004296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686004297 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710686004298 catalytic loop [active] 710686004299 iron binding site [ion binding]; other site 710686004300 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710686004301 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710686004302 putative di-iron ligands [ion binding]; other site 710686004303 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710686004304 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 710686004305 putative DNA binding site [nucleotide binding]; other site 710686004306 catalytic residue [active] 710686004307 putative H2TH interface [polypeptide binding]; other site 710686004308 putative catalytic residues [active] 710686004309 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710686004310 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710686004311 oxidoreductase; Provisional; Region: PRK06196 710686004312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004313 NAD(P) binding site [chemical binding]; other site 710686004314 active site 710686004315 Nitronate monooxygenase; Region: NMO; pfam03060 710686004316 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686004317 FMN binding site [chemical binding]; other site 710686004318 substrate binding site [chemical binding]; other site 710686004319 putative catalytic residue [active] 710686004320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686004321 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 710686004322 ATP binding site [chemical binding]; other site 710686004323 putative Mg++ binding site [ion binding]; other site 710686004324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686004325 nucleotide binding region [chemical binding]; other site 710686004326 ATP-binding site [chemical binding]; other site 710686004327 DEAD/H associated; Region: DEAD_assoc; pfam08494 710686004328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004330 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710686004331 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710686004332 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710686004333 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710686004334 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710686004335 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710686004336 aldehyde dehydrogenase family 7 member; Region: PLN02315 710686004337 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 710686004338 tetrameric interface [polypeptide binding]; other site 710686004339 NAD binding site [chemical binding]; other site 710686004340 catalytic residues [active] 710686004341 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 710686004342 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710686004343 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710686004344 AsnC family; Region: AsnC_trans_reg; pfam01037 710686004345 L-lysine aminotransferase; Provisional; Region: PRK08297 710686004346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686004347 inhibitor-cofactor binding pocket; inhibition site 710686004348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686004349 catalytic residue [active] 710686004350 Restriction endonuclease; Region: Mrr_cat; pfam04471 710686004351 PAS fold; Region: PAS_3; pfam08447 710686004352 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686004353 CsbD-like; Region: CsbD; cl17424 710686004354 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 710686004355 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 710686004356 putative ADP-binding pocket [chemical binding]; other site 710686004357 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 710686004358 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 710686004359 active site 710686004360 DNA binding site [nucleotide binding] 710686004361 Int/Topo IB signature motif; other site 710686004362 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 710686004363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710686004364 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710686004365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686004366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710686004367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686004368 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686004369 anti sigma factor interaction site; other site 710686004370 regulatory phosphorylation site [posttranslational modification]; other site 710686004371 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 710686004372 metal-binding site 710686004373 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 710686004374 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 710686004375 dimer interface [polypeptide binding]; other site 710686004376 active site 710686004377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686004378 substrate binding site [chemical binding]; other site 710686004379 catalytic residue [active] 710686004380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004381 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710686004382 NAD(P) binding site [chemical binding]; other site 710686004383 active site 710686004384 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 710686004385 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686004386 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710686004387 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710686004388 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686004389 carboxyltransferase (CT) interaction site; other site 710686004390 biotinylation site [posttranslational modification]; other site 710686004391 Fe-S metabolism associated domain; Region: SufE; cl00951 710686004392 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710686004393 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710686004394 active site residue [active] 710686004395 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710686004396 active site residue [active] 710686004397 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686004398 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 710686004399 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710686004400 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 710686004401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686004402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004403 NAD(P) binding site [chemical binding]; other site 710686004404 active site 710686004405 Maf-like protein; Region: Maf; pfam02545 710686004406 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 710686004407 active site 710686004408 dimer interface [polypeptide binding]; other site 710686004409 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 710686004410 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710686004411 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686004412 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686004413 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710686004414 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710686004415 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 710686004416 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 710686004417 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 710686004418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004419 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 710686004420 NAD(P) binding site [chemical binding]; other site 710686004421 active site 710686004422 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 710686004423 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 710686004424 NADP-binding site; other site 710686004425 homotetramer interface [polypeptide binding]; other site 710686004426 substrate binding site [chemical binding]; other site 710686004427 homodimer interface [polypeptide binding]; other site 710686004428 active site 710686004429 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 710686004430 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 710686004431 NADP binding site [chemical binding]; other site 710686004432 active site 710686004433 putative substrate binding site [chemical binding]; other site 710686004434 Bacterial PH domain; Region: DUF304; pfam03703 710686004435 Predicted membrane protein [Function unknown]; Region: COG2246 710686004436 GtrA-like protein; Region: GtrA; pfam04138 710686004437 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 710686004438 ATP-grasp domain; Region: ATP-grasp; pfam02222 710686004439 AIR carboxylase; Region: AIRC; pfam00731 710686004440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686004441 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 710686004442 FAD binding site [chemical binding]; other site 710686004443 homotetramer interface [polypeptide binding]; other site 710686004444 substrate binding pocket [chemical binding]; other site 710686004445 catalytic base [active] 710686004446 putative glycosyl transferase; Provisional; Region: PRK10307 710686004447 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710686004448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686004449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710686004450 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710686004451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686004452 active site 710686004453 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710686004454 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686004455 active site 710686004456 catalytic triad [active] 710686004457 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 710686004458 putative trimer interface [polypeptide binding]; other site 710686004459 putative active site [active] 710686004460 putative substrate binding site [chemical binding]; other site 710686004461 putative CoA binding site [chemical binding]; other site 710686004462 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 710686004463 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 710686004464 Chain length determinant protein; Region: Wzz; cl15801 710686004465 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686004466 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710686004467 Chain length determinant protein; Region: Wzz; pfam02706 710686004468 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710686004469 putative trimer interface [polypeptide binding]; other site 710686004470 putative CoA binding site [chemical binding]; other site 710686004471 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686004472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686004473 S-adenosylmethionine binding site [chemical binding]; other site 710686004474 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686004475 active site 710686004476 catalytic triad [active] 710686004477 TIGR03089 family protein; Region: TIGR03089 710686004478 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710686004479 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710686004480 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 710686004481 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 710686004482 NADP binding site [chemical binding]; other site 710686004483 active site 710686004484 putative substrate binding site [chemical binding]; other site 710686004485 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710686004486 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710686004487 Probable Catalytic site; other site 710686004488 metal-binding site 710686004489 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 710686004490 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 710686004491 active site 710686004492 Substrate binding site; other site 710686004493 Mg++ binding site; other site 710686004494 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710686004495 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 710686004496 nudix motif; other site 710686004497 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 710686004498 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 710686004499 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 710686004500 putative FMN binding site [chemical binding]; other site 710686004501 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 710686004502 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 710686004503 phosphate binding site [ion binding]; other site 710686004504 dimer interface [polypeptide binding]; other site 710686004505 substrate binding site [chemical binding]; other site 710686004506 Transcription factor WhiB; Region: Whib; pfam02467 710686004507 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 710686004508 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 710686004509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686004510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686004511 S-adenosylmethionine binding site [chemical binding]; other site 710686004512 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 710686004513 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 710686004514 active site 710686004515 substrate binding site [chemical binding]; other site 710686004516 metal binding site [ion binding]; metal-binding site 710686004517 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 710686004518 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710686004519 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710686004520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 710686004521 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686004522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686004523 active site 710686004524 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686004525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686004526 amino acid transporter; Region: 2A0306; TIGR00909 710686004527 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 710686004528 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 710686004529 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710686004530 Di-iron ligands [ion binding]; other site 710686004531 Rubredoxin; Region: Rubredoxin; pfam00301 710686004532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710686004533 iron binding site [ion binding]; other site 710686004534 Rubredoxin [Energy production and conversion]; Region: COG1773 710686004535 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710686004536 iron binding site [ion binding]; other site 710686004537 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 710686004538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004539 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 710686004540 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 710686004541 homotetramer interface [polypeptide binding]; other site 710686004542 ligand binding site [chemical binding]; other site 710686004543 catalytic site [active] 710686004544 NAD binding site [chemical binding]; other site 710686004545 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 710686004546 TMP-binding site; other site 710686004547 ATP-binding site [chemical binding]; other site 710686004548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686004549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686004550 active site 710686004551 phosphorylation site [posttranslational modification] 710686004552 intermolecular recognition site; other site 710686004553 dimerization interface [polypeptide binding]; other site 710686004554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686004555 DNA binding site [nucleotide binding] 710686004556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686004557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686004558 dimerization interface [polypeptide binding]; other site 710686004559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686004560 dimer interface [polypeptide binding]; other site 710686004561 phosphorylation site [posttranslational modification] 710686004562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686004563 ATP binding site [chemical binding]; other site 710686004564 Mg2+ binding site [ion binding]; other site 710686004565 G-X-G motif; other site 710686004566 lipoprotein LpqB; Provisional; Region: PRK13616 710686004567 Sporulation and spore germination; Region: Germane; pfam10646 710686004568 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710686004569 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 710686004570 iron-sulfur cluster [ion binding]; other site 710686004571 [2Fe-2S] cluster binding site [ion binding]; other site 710686004572 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 710686004573 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 710686004574 30S subunit binding site; other site 710686004575 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 710686004576 DEAD/DEAH box helicase; Region: DEAD; pfam00270 710686004577 ATP binding site [chemical binding]; other site 710686004578 putative Mg++ binding site [ion binding]; other site 710686004579 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710686004580 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686004581 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686004582 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710686004583 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686004584 FAD binding pocket [chemical binding]; other site 710686004585 FAD binding motif [chemical binding]; other site 710686004586 phosphate binding motif [ion binding]; other site 710686004587 beta-alpha-beta structure motif; other site 710686004588 NAD binding pocket [chemical binding]; other site 710686004589 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710686004590 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686004591 catalytic loop [active] 710686004592 iron binding site [ion binding]; other site 710686004593 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710686004594 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710686004595 putative di-iron ligands [ion binding]; other site 710686004596 Predicted GTPases [General function prediction only]; Region: COG1162 710686004597 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 710686004598 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710686004599 GTP/Mg2+ binding site [chemical binding]; other site 710686004600 G4 box; other site 710686004601 G5 box; other site 710686004602 G1 box; other site 710686004603 Switch I region; other site 710686004604 G2 box; other site 710686004605 G3 box; other site 710686004606 Switch II region; other site 710686004607 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 710686004608 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 710686004609 hinge; other site 710686004610 active site 710686004611 Uncharacterized conserved protein [Function unknown]; Region: COG2135 710686004612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004614 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686004615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686004616 substrate binding site [chemical binding]; other site 710686004617 oxyanion hole (OAH) forming residues; other site 710686004618 trimer interface [polypeptide binding]; other site 710686004619 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710686004620 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 710686004621 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 710686004622 NAD(P) binding site [chemical binding]; other site 710686004623 catalytic residues [active] 710686004624 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710686004625 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686004626 NAD binding site [chemical binding]; other site 710686004627 catalytic Zn binding site [ion binding]; other site 710686004628 substrate binding site [chemical binding]; other site 710686004629 structural Zn binding site [ion binding]; other site 710686004630 short chain dehydrogenase; Provisional; Region: PRK08278 710686004631 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 710686004632 NAD(P) binding site [chemical binding]; other site 710686004633 homodimer interface [polypeptide binding]; other site 710686004634 active site 710686004635 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 710686004636 putative deacylase active site [active] 710686004637 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710686004638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686004639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686004640 DNA binding residues [nucleotide binding] 710686004641 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 710686004642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686004643 carboxyltransferase (CT) interaction site; other site 710686004644 biotinylation site [posttranslational modification]; other site 710686004645 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 710686004646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710686004647 Histidine kinase; Region: HisKA_2; pfam07568 710686004648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686004649 ATP binding site [chemical binding]; other site 710686004650 Mg2+ binding site [ion binding]; other site 710686004651 G-X-G motif; other site 710686004652 Transcription factor WhiB; Region: Whib; pfam02467 710686004653 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710686004654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710686004655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686004656 Coenzyme A binding pocket [chemical binding]; other site 710686004657 isochorismate synthase DhbC; Validated; Region: PRK06923 710686004658 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710686004659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686004660 catalytic core [active] 710686004661 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686004662 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686004663 P-loop; other site 710686004664 Magnesium ion binding site [ion binding]; other site 710686004665 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 710686004666 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686004667 Magnesium ion binding site [ion binding]; other site 710686004668 short chain dehydrogenase; Validated; Region: PRK08264 710686004669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686004670 NAD(P) binding site [chemical binding]; other site 710686004671 active site 710686004672 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710686004673 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710686004674 ATP binding site [chemical binding]; other site 710686004675 Mg++ binding site [ion binding]; other site 710686004676 motif III; other site 710686004677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686004678 nucleotide binding region [chemical binding]; other site 710686004679 ATP-binding site [chemical binding]; other site 710686004680 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710686004681 dinuclear metal binding motif [ion binding]; other site 710686004682 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 710686004683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004685 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 710686004686 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 710686004687 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 710686004688 ATP binding site [chemical binding]; other site 710686004689 substrate interface [chemical binding]; other site 710686004690 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710686004691 active site residue [active] 710686004692 TIGR02569 family protein; Region: TIGR02569_actnb 710686004693 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710686004694 active site 710686004695 DNA binding site [nucleotide binding] 710686004696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686004697 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686004698 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710686004699 catalytic site [active] 710686004700 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710686004701 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710686004702 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710686004703 Part of AAA domain; Region: AAA_19; pfam13245 710686004704 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710686004705 Ion channel; Region: Ion_trans_2; pfam07885 710686004706 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710686004707 TrkA-N domain; Region: TrkA_N; pfam02254 710686004708 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 710686004709 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 710686004710 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 710686004711 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 710686004712 putative NADH binding site [chemical binding]; other site 710686004713 putative active site [active] 710686004714 nudix motif; other site 710686004715 putative metal binding site [ion binding]; other site 710686004716 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710686004717 catalytic residues [active] 710686004718 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710686004719 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710686004720 Family description; Region: UvrD_C_2; pfam13538 710686004721 HRDC domain; Region: HRDC; pfam00570 710686004722 Transcription factor WhiB; Region: Whib; pfam02467 710686004723 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710686004724 ABC1 family; Region: ABC1; pfam03109 710686004725 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710686004726 active site 710686004727 ATP binding site [chemical binding]; other site 710686004728 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 710686004729 Uncharacterized conserved protein [Function unknown]; Region: COG5282 710686004730 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710686004731 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 710686004732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710686004733 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710686004734 hypothetical protein; Validated; Region: PRK00068 710686004735 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 710686004736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686004737 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 710686004738 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686004739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686004740 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 710686004741 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686004742 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 710686004743 putative NAD(P) binding site [chemical binding]; other site 710686004744 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710686004745 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710686004746 dimerization interface [polypeptide binding]; other site 710686004747 active site 710686004748 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710686004749 RibD C-terminal domain; Region: RibD_C; cl17279 710686004750 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710686004751 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710686004752 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710686004753 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 710686004754 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710686004755 ring oligomerisation interface [polypeptide binding]; other site 710686004756 ATP/Mg binding site [chemical binding]; other site 710686004757 stacking interactions; other site 710686004758 hinge regions; other site 710686004759 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686004760 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 710686004761 NAD binding site [chemical binding]; other site 710686004762 substrate binding site [chemical binding]; other site 710686004763 catalytic Zn binding site [ion binding]; other site 710686004764 structural Zn binding site [ion binding]; other site 710686004765 Domain of unknown function DUF59; Region: DUF59; pfam01883 710686004766 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710686004767 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710686004768 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710686004769 dimerization interface [polypeptide binding]; other site 710686004770 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710686004771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686004772 catalytic loop [active] 710686004773 iron binding site [ion binding]; other site 710686004774 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 710686004775 FAD binding pocket [chemical binding]; other site 710686004776 FAD binding motif [chemical binding]; other site 710686004777 phosphate binding motif [ion binding]; other site 710686004778 beta-alpha-beta structure motif; other site 710686004779 NAD binding pocket [chemical binding]; other site 710686004780 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710686004781 dimerization interface [polypeptide binding]; other site 710686004782 putative path to active site cavity [active] 710686004783 diiron center [ion binding]; other site 710686004784 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 710686004785 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710686004786 DNA-binding interface [nucleotide binding]; DNA binding site 710686004787 calcium/proton exchanger (cax); Region: cax; TIGR00378 710686004788 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686004789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686004790 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686004791 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686004792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004794 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 710686004795 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 710686004796 putative molybdopterin cofactor binding site [chemical binding]; other site 710686004797 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 710686004798 putative molybdopterin cofactor binding site; other site 710686004799 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 710686004800 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 710686004801 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 710686004802 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 710686004803 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 710686004804 ligand binding site [chemical binding]; other site 710686004805 homodimer interface [polypeptide binding]; other site 710686004806 NAD(P) binding site [chemical binding]; other site 710686004807 trimer interface B [polypeptide binding]; other site 710686004808 trimer interface A [polypeptide binding]; other site 710686004809 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 710686004810 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710686004811 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710686004812 pyruvate kinase; Provisional; Region: PRK06247 710686004813 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710686004814 domain interfaces; other site 710686004815 active site 710686004816 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 710686004817 PAS domain S-box; Region: sensory_box; TIGR00229 710686004818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686004819 putative active site [active] 710686004820 heme pocket [chemical binding]; other site 710686004821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686004822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686004823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 710686004824 dimerization interface [polypeptide binding]; other site 710686004825 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 710686004826 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686004827 PYR/PP interface [polypeptide binding]; other site 710686004828 dimer interface [polypeptide binding]; other site 710686004829 TPP binding site [chemical binding]; other site 710686004830 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686004831 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710686004832 TPP-binding site; other site 710686004833 dimer interface [polypeptide binding]; other site 710686004834 formyl-coenzyme A transferase; Provisional; Region: PRK05398 710686004835 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686004836 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 710686004837 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 710686004838 putative dimer interface [polypeptide binding]; other site 710686004839 [2Fe-2S] cluster binding site [ion binding]; other site 710686004840 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 710686004841 putative dimer interface [polypeptide binding]; other site 710686004842 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710686004843 SLBB domain; Region: SLBB; pfam10531 710686004844 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 710686004845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686004846 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 710686004847 catalytic loop [active] 710686004848 iron binding site [ion binding]; other site 710686004849 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 710686004850 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 710686004851 [4Fe-4S] binding site [ion binding]; other site 710686004852 molybdopterin cofactor binding site; other site 710686004853 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 710686004854 molybdopterin cofactor binding site; other site 710686004855 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 710686004856 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686004857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686004858 active site 710686004859 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 710686004860 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 710686004861 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710686004862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686004863 DNA-binding site [nucleotide binding]; DNA binding site 710686004864 FCD domain; Region: FCD; pfam07729 710686004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686004866 formyl-coenzyme A transferase; Provisional; Region: PRK05398 710686004867 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686004868 formyl-coenzyme A transferase; Provisional; Region: PRK05398 710686004869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686004870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686004871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686004872 putative substrate translocation pore; other site 710686004873 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710686004874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686004875 DNA-binding site [nucleotide binding]; DNA binding site 710686004876 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686004877 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686004878 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686004879 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686004880 glyoxylate carboligase; Provisional; Region: PRK11269 710686004881 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686004882 PYR/PP interface [polypeptide binding]; other site 710686004883 dimer interface [polypeptide binding]; other site 710686004884 TPP binding site [chemical binding]; other site 710686004885 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686004886 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 710686004887 TPP-binding site [chemical binding]; other site 710686004888 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 710686004889 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686004890 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 710686004891 Glycerate kinase family; Region: Gly_kinase; cl00841 710686004892 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686004893 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710686004894 NAD(P) binding site [chemical binding]; other site 710686004895 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686004896 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686004897 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710686004898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686004899 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710686004900 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686004901 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686004902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686004903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686004904 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686004905 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686004906 putative active site [active] 710686004907 putative substrate binding site [chemical binding]; other site 710686004908 ATP binding site [chemical binding]; other site 710686004909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004911 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 710686004912 Carboxylesterase family; Region: COesterase; pfam00135 710686004913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686004914 substrate binding pocket [chemical binding]; other site 710686004915 catalytic triad [active] 710686004916 enoyl-CoA hydratase; Provisional; Region: PRK06190 710686004917 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686004918 substrate binding site [chemical binding]; other site 710686004919 oxyanion hole (OAH) forming residues; other site 710686004920 trimer interface [polypeptide binding]; other site 710686004921 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 710686004922 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710686004923 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 710686004924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710686004925 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 710686004926 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710686004927 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710686004928 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 710686004929 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 710686004930 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 710686004931 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 710686004932 4Fe-4S binding domain; Region: Fer4; pfam00037 710686004933 4Fe-4S binding domain; Region: Fer4; pfam00037 710686004934 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 710686004935 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 710686004936 NADH dehydrogenase subunit G; Validated; Region: PRK07860 710686004937 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686004938 catalytic loop [active] 710686004939 iron binding site [ion binding]; other site 710686004940 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 710686004941 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686004942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686004943 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 710686004944 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 710686004945 SLBB domain; Region: SLBB; pfam10531 710686004946 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710686004947 NADH dehydrogenase subunit E; Validated; Region: PRK07539 710686004948 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 710686004949 putative dimer interface [polypeptide binding]; other site 710686004950 [2Fe-2S] cluster binding site [ion binding]; other site 710686004951 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 710686004952 NADH dehydrogenase subunit D; Validated; Region: PRK06075 710686004953 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 710686004954 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 710686004955 NADH dehydrogenase subunit B; Validated; Region: PRK06411 710686004956 NADH dehydrogenase subunit A; Validated; Region: PRK07928 710686004957 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710686004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686004959 active site 710686004960 phosphorylation site [posttranslational modification] 710686004961 intermolecular recognition site; other site 710686004962 dimerization interface [polypeptide binding]; other site 710686004963 YceI-like domain; Region: YceI; pfam04264 710686004964 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686004965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686004966 S-adenosylmethionine binding site [chemical binding]; other site 710686004967 TIGR03086 family protein; Region: TIGR03086 710686004968 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686004969 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686004970 MarR family; Region: MarR_2; pfam12802 710686004971 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686004972 putative active site [active] 710686004973 putative substrate binding site [chemical binding]; other site 710686004974 ATP binding site [chemical binding]; other site 710686004975 Phosphotransferase enzyme family; Region: APH; pfam01636 710686004976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686004977 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686004978 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686004979 active site 710686004980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686004981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004982 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710686004983 active site 710686004984 catalytic residues [active] 710686004985 metal binding site [ion binding]; metal-binding site 710686004986 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686004987 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686004988 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686004989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686004990 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 710686004991 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686004992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686004993 Putative esterase; Region: Esterase; pfam00756 710686004994 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 710686004995 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 710686004996 NADP binding site [chemical binding]; other site 710686004997 dimer interface [polypeptide binding]; other site 710686004998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686004999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005000 active site 710686005001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005003 active site 710686005004 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 710686005005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686005006 FeS/SAM binding site; other site 710686005007 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710686005008 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 710686005009 active site 710686005010 ferredoxin-NADP+ reductase; Region: PLN02852 710686005011 peptide chain release factor 2; Validated; Region: prfB; PRK00578 710686005012 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710686005013 RF-1 domain; Region: RF-1; pfam00472 710686005014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710686005015 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710686005016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 710686005017 Probable transposase; Region: OrfB_IS605; pfam01385 710686005018 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 710686005019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686005020 Walker A/P-loop; other site 710686005021 ATP binding site [chemical binding]; other site 710686005022 Q-loop/lid; other site 710686005023 ABC transporter signature motif; other site 710686005024 Walker B; other site 710686005025 D-loop; other site 710686005026 H-loop/switch region; other site 710686005027 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 710686005028 FtsX-like permease family; Region: FtsX; pfam02687 710686005029 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710686005030 SmpB-tmRNA interface; other site 710686005031 EamA-like transporter family; Region: EamA; pfam00892 710686005032 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686005033 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686005034 short chain dehydrogenase; Provisional; Region: PRK06500 710686005035 classical (c) SDRs; Region: SDR_c; cd05233 710686005036 NAD(P) binding site [chemical binding]; other site 710686005037 active site 710686005038 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686005039 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686005040 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710686005041 FMN binding site [chemical binding]; other site 710686005042 dimer interface [polypeptide binding]; other site 710686005043 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686005044 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710686005045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005047 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710686005048 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710686005049 putative di-iron ligands [ion binding]; other site 710686005050 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686005051 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 710686005052 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710686005053 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 710686005054 DNA binding residues [nucleotide binding] 710686005055 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686005056 classical (c) SDRs; Region: SDR_c; cd05233 710686005057 NAD(P) binding site [chemical binding]; other site 710686005058 active site 710686005059 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686005060 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686005061 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 710686005062 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686005063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005064 NAD(P) binding site [chemical binding]; other site 710686005065 active site 710686005066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005068 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710686005069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686005070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686005071 active site 710686005072 ATP binding site [chemical binding]; other site 710686005073 substrate binding site [chemical binding]; other site 710686005074 activation loop (A-loop); other site 710686005075 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710686005076 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 710686005077 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710686005078 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710686005079 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710686005080 active site 710686005081 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710686005082 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710686005083 active site 710686005084 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 710686005085 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686005086 active site 710686005087 metal binding site [ion binding]; metal-binding site 710686005088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686005089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686005090 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710686005091 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710686005092 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686005093 active site 710686005094 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686005095 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686005096 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686005097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686005098 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686005099 cyclase homology domain; Region: CHD; cd07302 710686005100 nucleotidyl binding site; other site 710686005101 metal binding site [ion binding]; metal-binding site 710686005102 dimer interface [polypeptide binding]; other site 710686005103 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 710686005104 active site 710686005105 diiron metal binding site [ion binding]; other site 710686005106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005108 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710686005109 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 710686005110 putative active site [active] 710686005111 putative FMN binding site [chemical binding]; other site 710686005112 putative substrate binding site [chemical binding]; other site 710686005113 putative catalytic residue [active] 710686005114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005116 WHG domain; Region: WHG; pfam13305 710686005117 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 710686005118 amphipathic channel; other site 710686005119 Asn-Pro-Ala signature motifs; other site 710686005120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005122 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686005123 dinuclear metal binding motif [ion binding]; other site 710686005124 CCC1-related family of proteins; Region: CCC1_like; cl00278 710686005125 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710686005126 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686005127 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710686005128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686005129 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686005130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686005131 active site 710686005132 metal binding site [ion binding]; metal-binding site 710686005133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686005134 active site 710686005135 metal binding site [ion binding]; metal-binding site 710686005136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686005137 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686005138 putative hydrophobic ligand binding site [chemical binding]; other site 710686005139 protein interface [polypeptide binding]; other site 710686005140 gate; other site 710686005141 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686005142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686005143 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710686005144 Sulfatase; Region: Sulfatase; pfam00884 710686005145 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 710686005146 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686005147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686005148 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686005149 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686005150 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 710686005151 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686005152 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 710686005153 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686005154 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686005155 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 710686005156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686005157 putative NAD(P) binding site [chemical binding]; other site 710686005158 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686005159 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686005160 MarR family; Region: MarR_2; pfam12802 710686005161 MarR family; Region: MarR_2; cl17246 710686005162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686005163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686005164 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 710686005165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686005166 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 710686005167 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686005168 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686005169 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 710686005170 gating phenylalanine in ion channel; other site 710686005171 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 710686005172 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 710686005173 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 710686005174 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686005175 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710686005176 enoyl-CoA hydratase; Provisional; Region: PRK08252 710686005177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686005178 substrate binding site [chemical binding]; other site 710686005179 oxyanion hole (OAH) forming residues; other site 710686005180 trimer interface [polypeptide binding]; other site 710686005181 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686005182 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686005183 acyl-coenzyme A oxidase; Region: PLN02526 710686005184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005185 active site 710686005186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005188 salt bridge; other site 710686005189 non-specific DNA binding site [nucleotide binding]; other site 710686005190 sequence-specific DNA binding site [nucleotide binding]; other site 710686005191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005192 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686005193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005195 active site 710686005196 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686005197 classical (c) SDRs; Region: SDR_c; cd05233 710686005198 NAD(P) binding site [chemical binding]; other site 710686005199 active site 710686005200 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686005201 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710686005202 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710686005203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686005204 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686005205 FtsJ-like methyltransferase; Region: FtsJ; cl17430 710686005206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686005207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686005208 S-adenosylmethionine binding site [chemical binding]; other site 710686005209 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686005210 Domain of unknown function DUF302; Region: DUF302; cl01364 710686005211 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686005212 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686005213 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005214 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686005215 classical (c) SDRs; Region: SDR_c; cd05233 710686005216 NAD(P) binding site [chemical binding]; other site 710686005217 active site 710686005218 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 710686005219 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686005220 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686005221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686005222 Ligand Binding Site [chemical binding]; other site 710686005223 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710686005224 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710686005225 short chain dehydrogenase; Provisional; Region: PRK06180 710686005226 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686005227 NADP binding site [chemical binding]; other site 710686005228 active site 710686005229 steroid binding site; other site 710686005230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686005231 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686005232 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686005233 cyclase homology domain; Region: CHD; cd07302 710686005234 nucleotidyl binding site; other site 710686005235 metal binding site [ion binding]; metal-binding site 710686005236 dimer interface [polypeptide binding]; other site 710686005237 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 710686005238 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 710686005239 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 710686005240 active site turn [active] 710686005241 phosphorylation site [posttranslational modification] 710686005242 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 710686005243 HPr interaction site; other site 710686005244 glycerol kinase (GK) interaction site [polypeptide binding]; other site 710686005245 active site 710686005246 phosphorylation site [posttranslational modification] 710686005247 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710686005248 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 710686005249 active site 710686005250 trimer interface [polypeptide binding]; other site 710686005251 allosteric site; other site 710686005252 active site lid [active] 710686005253 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 710686005254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686005255 active site 710686005256 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 710686005257 conserved cys residue [active] 710686005258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005260 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686005261 Cytochrome P450; Region: p450; cl12078 710686005262 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 710686005263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005265 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 710686005266 active sites [active] 710686005267 tetramer interface [polypeptide binding]; other site 710686005268 imidazolonepropionase; Provisional; Region: PRK14085 710686005269 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686005270 active site 710686005271 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 710686005272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686005273 active site 710686005274 allantoate amidohydrolase; Reviewed; Region: PRK09290 710686005275 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 710686005276 active site 710686005277 metal binding site [ion binding]; metal-binding site 710686005278 dimer interface [polypeptide binding]; other site 710686005279 urocanate hydratase; Provisional; Region: PRK05414 710686005280 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005281 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686005282 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686005283 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 710686005284 putative hydrophobic ligand binding site [chemical binding]; other site 710686005285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005286 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 710686005287 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 710686005288 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 710686005289 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710686005290 dimerization domain swap beta strand [polypeptide binding]; other site 710686005291 regulatory protein interface [polypeptide binding]; other site 710686005292 active site 710686005293 regulatory phosphorylation site [posttranslational modification]; other site 710686005294 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 710686005295 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710686005296 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710686005297 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710686005298 DAK2 domain; Region: Dak2; cl03685 710686005299 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 710686005300 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 710686005301 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 710686005302 amphipathic channel; other site 710686005303 Asn-Pro-Ala signature motifs; other site 710686005304 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686005305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005306 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686005307 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710686005308 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710686005309 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 710686005310 putative deacylase active site [active] 710686005311 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686005312 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686005313 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 710686005314 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 710686005315 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 710686005316 camphor resistance protein CrcB; Provisional; Region: PRK14228 710686005317 camphor resistance protein CrcB; Provisional; Region: PRK14216 710686005318 phosphoglucomutase; Validated; Region: PRK07564 710686005319 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 710686005320 active site 710686005321 substrate binding site [chemical binding]; other site 710686005322 metal binding site [ion binding]; metal-binding site 710686005323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686005324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686005325 putative substrate translocation pore; other site 710686005326 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710686005327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710686005328 active site 710686005329 DNA binding site [nucleotide binding] 710686005330 Int/Topo IB signature motif; other site 710686005331 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686005332 Domain of unknown function (DUF955); Region: DUF955; pfam06114 710686005333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005335 non-specific DNA binding site [nucleotide binding]; other site 710686005336 salt bridge; other site 710686005337 sequence-specific DNA binding site [nucleotide binding]; other site 710686005338 Antirestriction protein (ArdA); Region: ArdA; pfam07275 710686005339 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 710686005340 DNA methylase; Region: N6_N4_Mtase; pfam01555 710686005341 Replication-relaxation; Region: Replic_Relax; pfam13814 710686005342 AAA-like domain; Region: AAA_10; pfam12846 710686005343 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710686005344 Walker A motif; other site 710686005345 ATP binding site [chemical binding]; other site 710686005346 Walker B motif; other site 710686005347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005349 non-specific DNA binding site [nucleotide binding]; other site 710686005350 salt bridge; other site 710686005351 sequence-specific DNA binding site [nucleotide binding]; other site 710686005352 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686005353 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 710686005354 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 710686005355 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 710686005356 Right handed beta helix region; Region: Beta_helix; pfam13229 710686005357 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710686005358 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 710686005359 DNA methylase; Region: N6_N4_Mtase; cl17433 710686005360 DNA methylase; Region: N6_N4_Mtase; cl17433 710686005361 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 710686005362 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 710686005363 active site 710686005364 catalytic residues [active] 710686005365 metal binding site [ion binding]; metal-binding site 710686005366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686005367 classical (c) SDRs; Region: SDR_c; cd05233 710686005368 NAD(P) binding site [chemical binding]; other site 710686005369 active site 710686005370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005372 Domain of unknown function (DUF336); Region: DUF336; pfam03928 710686005373 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710686005374 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686005375 Permease; Region: Permease; pfam02405 710686005376 Permease; Region: Permease; pfam02405 710686005377 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005378 mce related protein; Region: MCE; pfam02470 710686005379 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686005380 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710686005381 mce related protein; Region: MCE; pfam02470 710686005382 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686005383 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005384 mce related protein; Region: MCE; pfam02470 710686005385 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005386 mce related protein; Region: MCE; pfam02470 710686005387 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005388 mce related protein; Region: MCE; pfam02470 710686005389 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686005390 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005391 mce related protein; Region: MCE; pfam02470 710686005392 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686005393 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686005394 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 710686005395 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710686005396 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710686005397 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686005398 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686005399 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710686005400 active site 710686005401 catalytic residues [active] 710686005402 metal binding site [ion binding]; metal-binding site 710686005403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005405 active site 710686005406 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 710686005407 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686005408 phosphate binding site [ion binding]; other site 710686005409 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686005410 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005411 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686005412 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 710686005413 Cupin domain; Region: Cupin_2; pfam07883 710686005414 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686005415 FAD binding domain; Region: FAD_binding_3; pfam01494 710686005416 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 710686005417 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710686005418 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 710686005419 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710686005420 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 710686005421 AsnC family; Region: AsnC_trans_reg; pfam01037 710686005422 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710686005423 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 710686005424 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710686005425 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710686005426 TPP-binding site [chemical binding]; other site 710686005427 tetramer interface [polypeptide binding]; other site 710686005428 heterodimer interface [polypeptide binding]; other site 710686005429 phosphorylation loop region [posttranslational modification] 710686005430 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710686005431 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710686005432 alpha subunit interface [polypeptide binding]; other site 710686005433 TPP binding site [chemical binding]; other site 710686005434 heterodimer interface [polypeptide binding]; other site 710686005435 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686005436 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710686005437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686005438 E3 interaction surface; other site 710686005439 lipoyl attachment site [posttranslational modification]; other site 710686005440 e3 binding domain; Region: E3_binding; pfam02817 710686005441 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710686005442 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 710686005443 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 710686005444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686005445 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686005446 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710686005447 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686005448 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686005449 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686005450 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686005451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686005452 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686005453 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686005454 FAD binding domain; Region: FAD_binding_4; pfam01565 710686005455 Berberine and berberine like; Region: BBE; pfam08031 710686005456 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710686005457 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 710686005458 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686005459 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686005460 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710686005461 conserved cys residue [active] 710686005462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686005463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686005464 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686005465 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710686005466 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686005467 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686005468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005470 WHG domain; Region: WHG; pfam13305 710686005471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005473 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710686005476 NAD(P) binding site [chemical binding]; other site 710686005477 active site 710686005478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686005479 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686005480 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 710686005481 NmrA-like family; Region: NmrA; pfam05368 710686005482 NADP binding site [chemical binding]; other site 710686005483 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686005484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005485 NAD(P) binding site [chemical binding]; other site 710686005486 active site 710686005487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005489 Cupin domain; Region: Cupin_2; pfam07883 710686005490 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686005491 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 710686005492 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 710686005493 tetramer interface [polypeptide binding]; other site 710686005494 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 710686005495 tetramer interface [polypeptide binding]; other site 710686005496 active site 710686005497 metal binding site [ion binding]; metal-binding site 710686005498 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686005499 MarR family; Region: MarR_2; pfam12802 710686005500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686005501 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710686005502 putative catalytic cysteine [active] 710686005503 Secretory lipase; Region: LIP; pfam03583 710686005504 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710686005505 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710686005506 putative di-iron ligands [ion binding]; other site 710686005507 argininosuccinate lyase; Region: argH; TIGR00838 710686005508 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710686005509 tetramer interface [polypeptide binding]; other site 710686005510 D-cysteine desulfhydrase; Validated; Region: PRK03910 710686005511 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710686005512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686005513 catalytic residue [active] 710686005514 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 710686005515 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 710686005516 tetramer interface [polypeptide binding]; other site 710686005517 active site 710686005518 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 710686005519 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 710686005520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686005521 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686005522 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686005523 classical (c) SDRs; Region: SDR_c; cd05233 710686005524 NAD(P) binding site [chemical binding]; other site 710686005525 active site 710686005526 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710686005527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686005528 dimer interface [polypeptide binding]; other site 710686005529 conserved gate region; other site 710686005530 putative PBP binding loops; other site 710686005531 ABC-ATPase subunit interface; other site 710686005532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710686005533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686005534 Walker A/P-loop; other site 710686005535 ATP binding site [chemical binding]; other site 710686005536 Q-loop/lid; other site 710686005537 ABC transporter signature motif; other site 710686005538 Walker B; other site 710686005539 D-loop; other site 710686005540 H-loop/switch region; other site 710686005541 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710686005542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686005543 substrate binding pocket [chemical binding]; other site 710686005544 membrane-bound complex binding site; other site 710686005545 hinge residues; other site 710686005546 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710686005547 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 710686005548 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686005549 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710686005550 Coenzyme A transferase; Region: CoA_trans; cl17247 710686005551 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 710686005552 CoA binding domain; Region: CoA_binding_2; pfam13380 710686005553 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 710686005554 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 710686005555 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 710686005556 substrate binding site [chemical binding]; other site 710686005557 THF binding site; other site 710686005558 zinc-binding site [ion binding]; other site 710686005559 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710686005560 dimerization interface [polypeptide binding]; other site 710686005561 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710686005562 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710686005563 dimerization interface [polypeptide binding]; other site 710686005564 putative path to active site cavity [active] 710686005565 diiron center [ion binding]; other site 710686005566 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710686005567 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686005568 catalytic loop [active] 710686005569 iron binding site [ion binding]; other site 710686005570 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710686005571 FAD binding pocket [chemical binding]; other site 710686005572 conserved FAD binding motif [chemical binding]; other site 710686005573 phosphate binding motif [ion binding]; other site 710686005574 beta-alpha-beta structure motif; other site 710686005575 NAD binding pocket [chemical binding]; other site 710686005576 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710686005577 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710686005578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686005579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686005580 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686005581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686005582 classical (c) SDRs; Region: SDR_c; cd05233 710686005583 NAD(P) binding site [chemical binding]; other site 710686005584 active site 710686005585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686005586 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 710686005587 molybdopterin cofactor binding site; other site 710686005588 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 710686005589 molybdopterin cofactor binding site; other site 710686005590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686005591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005593 non-specific DNA binding site [nucleotide binding]; other site 710686005594 salt bridge; other site 710686005595 sequence-specific DNA binding site [nucleotide binding]; other site 710686005596 Domain of unknown function (DUF955); Region: DUF955; cl01076 710686005597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686005598 AAA domain; Region: AAA_21; pfam13304 710686005599 Walker A/P-loop; other site 710686005600 ATP binding site [chemical binding]; other site 710686005601 Part of AAA domain; Region: AAA_19; pfam13245 710686005602 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710686005603 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 710686005604 Int/Topo IB signature motif; other site 710686005605 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686005606 iron-sulfur cluster [ion binding]; other site 710686005607 [2Fe-2S] cluster binding site [ion binding]; other site 710686005608 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710686005609 alpha subunit interface [polypeptide binding]; other site 710686005610 active site 710686005611 substrate binding site [chemical binding]; other site 710686005612 Fe binding site [ion binding]; other site 710686005613 beta subunit interface [polypeptide binding]; other site 710686005614 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710686005615 inter-subunit interface; other site 710686005616 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710686005617 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686005618 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 710686005619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005620 NAD(P) binding site [chemical binding]; other site 710686005621 active site 710686005622 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005623 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686005624 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686005625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005627 sequence-specific DNA binding site [nucleotide binding]; other site 710686005628 salt bridge; other site 710686005629 Cupin domain; Region: Cupin_2; cl17218 710686005630 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686005631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686005632 classical (c) SDRs; Region: SDR_c; cd05233 710686005633 NAD(P) binding site [chemical binding]; other site 710686005634 active site 710686005635 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 710686005636 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686005637 active site 710686005638 metal binding site [ion binding]; metal-binding site 710686005639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686005640 active site 710686005641 metal binding site [ion binding]; metal-binding site 710686005642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686005643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686005644 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 710686005645 substrate binding pocket [chemical binding]; other site 710686005646 dimerization interface [polypeptide binding]; other site 710686005647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686005648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686005649 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 710686005650 dimerization interface [polypeptide binding]; other site 710686005651 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710686005652 active site 710686005653 inhibitor site; inhibition site 710686005654 dimer interface [polypeptide binding]; other site 710686005655 catalytic residue [active] 710686005656 succinic semialdehyde dehydrogenase; Region: PLN02278 710686005657 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710686005658 tetramerization interface [polypeptide binding]; other site 710686005659 NAD(P) binding site [chemical binding]; other site 710686005660 catalytic residues [active] 710686005661 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 710686005662 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 710686005663 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686005664 iron-sulfur cluster [ion binding]; other site 710686005665 [2Fe-2S] cluster binding site [ion binding]; other site 710686005666 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686005667 hydrophobic ligand binding site; other site 710686005668 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686005669 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686005670 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710686005671 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 710686005672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005673 NAD(P) binding site [chemical binding]; other site 710686005674 active site 710686005675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686005676 Putative cyclase; Region: Cyclase; pfam04199 710686005677 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710686005678 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710686005679 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686005680 Permease; Region: Permease; pfam02405 710686005681 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686005682 Permease; Region: Permease; pfam02405 710686005683 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005684 mce related protein; Region: MCE; pfam02470 710686005685 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686005686 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005687 mce related protein; Region: MCE; pfam02470 710686005688 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005689 mce related protein; Region: MCE; pfam02470 710686005690 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005691 mce related protein; Region: MCE; pfam02470 710686005692 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005693 mce related protein; Region: MCE; pfam02470 710686005694 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686005695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686005696 mce related protein; Region: MCE; pfam02470 710686005697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686005698 MarR family; Region: MarR_2; pfam12802 710686005699 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686005700 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686005701 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686005702 classical (c) SDRs; Region: SDR_c; cd05233 710686005703 NAD(P) binding site [chemical binding]; other site 710686005704 active site 710686005705 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686005706 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710686005707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686005708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686005709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686005710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005711 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710686005712 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686005713 active site 710686005714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686005715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686005716 substrate binding site [chemical binding]; other site 710686005717 oxyanion hole (OAH) forming residues; other site 710686005718 trimer interface [polypeptide binding]; other site 710686005719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005720 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686005721 active site 710686005722 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686005723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686005724 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686005725 acyl-activating enzyme (AAE) consensus motif; other site 710686005726 putative AMP binding site [chemical binding]; other site 710686005727 putative active site [active] 710686005728 putative CoA binding site [chemical binding]; other site 710686005729 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686005730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686005731 active site 710686005732 ATP binding site [chemical binding]; other site 710686005733 substrate binding site [chemical binding]; other site 710686005734 activation loop (A-loop); other site 710686005735 Predicted ATPase [General function prediction only]; Region: COG3903 710686005736 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686005737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686005738 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686005739 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686005740 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686005741 dinuclear metal binding motif [ion binding]; other site 710686005742 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710686005743 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686005744 dinuclear metal binding motif [ion binding]; other site 710686005745 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 710686005746 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710686005747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686005748 catalytic loop [active] 710686005749 iron binding site [ion binding]; other site 710686005750 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 710686005751 FAD binding pocket [chemical binding]; other site 710686005752 FAD binding motif [chemical binding]; other site 710686005753 phosphate binding motif [ion binding]; other site 710686005754 beta-alpha-beta structure motif; other site 710686005755 NAD binding pocket [chemical binding]; other site 710686005756 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 710686005757 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 710686005758 active site 710686005759 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 710686005760 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710686005761 active site 710686005762 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 710686005763 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710686005764 Coenzyme A transferase; Region: CoA_trans; cl17247 710686005765 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 710686005766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686005767 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686005768 Predicted ATPase [General function prediction only]; Region: COG3903 710686005769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686005771 DNA binding residues [nucleotide binding] 710686005772 dimerization interface [polypeptide binding]; other site 710686005773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686005774 classical (c) SDRs; Region: SDR_c; cd05233 710686005775 NAD(P) binding site [chemical binding]; other site 710686005776 active site 710686005777 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710686005778 FMN binding site [chemical binding]; other site 710686005779 dimer interface [polypeptide binding]; other site 710686005780 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686005781 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686005782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005783 active site 710686005784 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686005785 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710686005786 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686005787 FMN binding site [chemical binding]; other site 710686005788 substrate binding site [chemical binding]; other site 710686005789 putative catalytic residue [active] 710686005790 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710686005791 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710686005792 active site 710686005793 catalytic residues [active] 710686005794 metal binding site [ion binding]; metal-binding site 710686005795 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710686005796 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710686005797 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710686005798 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710686005799 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710686005800 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 710686005801 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 710686005802 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 710686005803 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 710686005804 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710686005805 putative active site [active] 710686005806 Fe(II) binding site [ion binding]; other site 710686005807 putative dimer interface [polypeptide binding]; other site 710686005808 putative tetramer interface [polypeptide binding]; other site 710686005809 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686005810 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686005811 NAD(P) binding site [chemical binding]; other site 710686005812 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 710686005813 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686005814 iron-sulfur cluster [ion binding]; other site 710686005815 [2Fe-2S] cluster binding site [ion binding]; other site 710686005816 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710686005817 beta subunit interface [polypeptide binding]; other site 710686005818 alpha subunit interface [polypeptide binding]; other site 710686005819 active site 710686005820 substrate binding site [chemical binding]; other site 710686005821 Fe binding site [ion binding]; other site 710686005822 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 710686005823 [2Fe-2S] cluster binding site [ion binding]; other site 710686005824 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710686005825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686005826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686005827 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710686005828 inter-subunit interface; other site 710686005829 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710686005830 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710686005831 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 710686005832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686005833 NAD(P) binding site [chemical binding]; other site 710686005834 active site 710686005835 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686005836 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686005837 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686005838 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686005839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686005840 sequence-specific DNA binding site [nucleotide binding]; other site 710686005841 salt bridge; other site 710686005842 Cupin domain; Region: Cupin_2; cl17218 710686005843 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686005844 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710686005845 dimer interface [polypeptide binding]; other site 710686005846 acyl-activating enzyme (AAE) consensus motif; other site 710686005847 putative active site [active] 710686005848 AMP binding site [chemical binding]; other site 710686005849 putative CoA binding site [chemical binding]; other site 710686005850 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686005851 cyclase homology domain; Region: CHD; cd07302 710686005852 nucleotidyl binding site; other site 710686005853 metal binding site [ion binding]; metal-binding site 710686005854 dimer interface [polypeptide binding]; other site 710686005855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686005860 Cytochrome P450; Region: p450; cl12078 710686005861 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686005862 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686005863 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 710686005864 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686005865 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686005866 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686005867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005869 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686005870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686005871 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 710686005872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686005873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686005874 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686005875 adenylate kinase; Reviewed; Region: adk; PRK00279 710686005876 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710686005877 AMP-binding site [chemical binding]; other site 710686005878 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710686005879 MarR family; Region: MarR; pfam01047 710686005880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686005881 MarR family; Region: MarR_2; cl17246 710686005882 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 710686005883 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686005884 DNA binding residues [nucleotide binding] 710686005885 drug binding residues [chemical binding]; other site 710686005886 dimer interface [polypeptide binding]; other site 710686005887 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 710686005888 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686005889 short chain dehydrogenase; Provisional; Region: PRK06500 710686005890 classical (c) SDRs; Region: SDR_c; cd05233 710686005891 NAD(P) binding site [chemical binding]; other site 710686005892 active site 710686005893 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686005894 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686005895 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686005896 YibE/F-like protein; Region: YibE_F; pfam07907 710686005897 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 710686005898 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 710686005899 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 710686005900 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 710686005901 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710686005902 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 710686005903 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 710686005904 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 710686005905 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710686005906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686005907 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686005908 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 710686005909 intersubunit interface [polypeptide binding]; other site 710686005910 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710686005911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686005912 Walker A/P-loop; other site 710686005913 ATP binding site [chemical binding]; other site 710686005914 Q-loop/lid; other site 710686005915 ABC transporter signature motif; other site 710686005916 Walker B; other site 710686005917 D-loop; other site 710686005918 H-loop/switch region; other site 710686005919 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710686005920 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 710686005921 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710686005922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 710686005923 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710686005924 metal binding site 2 [ion binding]; metal-binding site 710686005925 putative DNA binding helix; other site 710686005926 metal binding site 1 [ion binding]; metal-binding site 710686005927 dimer interface [polypeptide binding]; other site 710686005928 structural Zn2+ binding site [ion binding]; other site 710686005929 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710686005930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710686005931 active site 710686005932 metal binding site [ion binding]; metal-binding site 710686005933 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686005934 classical (c) SDRs; Region: SDR_c; cd05233 710686005935 NAD(P) binding site [chemical binding]; other site 710686005936 active site 710686005937 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 710686005938 RNA/DNA hybrid binding site [nucleotide binding]; other site 710686005939 active site 710686005940 enoyl-CoA hydratase; Provisional; Region: PRK07509 710686005941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686005942 substrate binding site [chemical binding]; other site 710686005943 oxyanion hole (OAH) forming residues; other site 710686005944 trimer interface [polypeptide binding]; other site 710686005945 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686005946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686005947 active site 710686005948 ATP binding site [chemical binding]; other site 710686005949 substrate binding site [chemical binding]; other site 710686005950 activation loop (A-loop); other site 710686005951 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710686005952 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710686005953 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686005954 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686005955 phosphopeptide binding site; other site 710686005956 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686005957 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686005958 phosphopeptide binding site; other site 710686005959 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710686005960 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710686005961 Walker A/P-loop; other site 710686005962 ATP binding site [chemical binding]; other site 710686005963 Q-loop/lid; other site 710686005964 ABC transporter signature motif; other site 710686005965 Walker B; other site 710686005966 D-loop; other site 710686005967 H-loop/switch region; other site 710686005968 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686005969 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686005970 putative acyl-acceptor binding pocket; other site 710686005971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686005972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686005973 lipid-transfer protein; Provisional; Region: PRK07855 710686005974 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686005975 active site 710686005976 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 710686005977 putative active site [active] 710686005978 putative catalytic site [active] 710686005979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005980 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686005981 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686005982 active site 710686005983 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686005984 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686005985 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686005986 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686005987 active site 710686005988 catalytic site [active] 710686005989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686005990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686005991 active site 710686005992 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686005993 Cytochrome P450; Region: p450; cl12078 710686005994 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686005995 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686005996 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686005997 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686005998 PE-PPE domain; Region: PE-PPE; pfam08237 710686005999 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 710686006000 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686006001 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686006002 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686006003 EamA-like transporter family; Region: EamA; pfam00892 710686006004 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 710686006005 EamA-like transporter family; Region: EamA; pfam00892 710686006006 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 710686006007 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710686006008 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686006009 active site 710686006010 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710686006011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006012 active site 710686006013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686006014 PAS domain; Region: PAS_9; pfam13426 710686006015 putative active site [active] 710686006016 heme pocket [chemical binding]; other site 710686006017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686006021 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710686006022 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710686006023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710686006024 metal binding site [ion binding]; metal-binding site 710686006025 active site 710686006026 I-site; other site 710686006027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710686006028 hypothetical protein; Provisional; Region: PRK07877 710686006029 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 710686006030 ATP binding site [chemical binding]; other site 710686006031 substrate interface [chemical binding]; other site 710686006032 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710686006033 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 710686006034 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 710686006035 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 710686006036 putative active site [active] 710686006037 putative substrate binding site [chemical binding]; other site 710686006038 putative cosubstrate binding site; other site 710686006039 catalytic site [active] 710686006040 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710686006041 putative active site [active] 710686006042 putative catalytic site [active] 710686006043 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686006044 classical (c) SDRs; Region: SDR_c; cd05233 710686006045 NAD(P) binding site [chemical binding]; other site 710686006046 active site 710686006047 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686006048 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006049 active site 710686006050 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686006051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006052 NAD(P) binding site [chemical binding]; other site 710686006053 active site 710686006054 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 710686006055 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686006056 dimer interface [polypeptide binding]; other site 710686006057 active site 710686006058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686006059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006060 active site 710686006061 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710686006062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686006063 DNA-binding site [nucleotide binding]; DNA binding site 710686006064 FCD domain; Region: FCD; pfam07729 710686006065 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 710686006066 Cytochrome P450; Region: p450; cl12078 710686006067 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686006068 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006069 acyl-activating enzyme (AAE) consensus motif; other site 710686006070 AMP binding site [chemical binding]; other site 710686006071 active site 710686006072 CoA binding site [chemical binding]; other site 710686006073 AMP-binding enzyme; Region: AMP-binding; pfam00501 710686006074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006075 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006076 acyl-activating enzyme (AAE) consensus motif; other site 710686006077 acyl-activating enzyme (AAE) consensus motif; other site 710686006078 AMP binding site [chemical binding]; other site 710686006079 active site 710686006080 CoA binding site [chemical binding]; other site 710686006081 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686006082 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006084 AMP binding site [chemical binding]; other site 710686006085 active site 710686006086 acyl-activating enzyme (AAE) consensus motif; other site 710686006087 acyl-activating enzyme (AAE) consensus motif; other site 710686006088 CoA binding site [chemical binding]; other site 710686006089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006090 enoyl-CoA hydratase; Provisional; Region: PRK06563 710686006091 substrate binding site [chemical binding]; other site 710686006092 oxyanion hole (OAH) forming residues; other site 710686006093 trimer interface [polypeptide binding]; other site 710686006094 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686006095 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006096 substrate binding site [chemical binding]; other site 710686006097 oxyanion hole (OAH) forming residues; other site 710686006098 trimer interface [polypeptide binding]; other site 710686006099 enoyl-CoA hydratase; Provisional; Region: PRK06688 710686006100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006101 substrate binding site [chemical binding]; other site 710686006102 oxyanion hole (OAH) forming residues; other site 710686006103 trimer interface [polypeptide binding]; other site 710686006104 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686006105 CoenzymeA binding site [chemical binding]; other site 710686006106 subunit interaction site [polypeptide binding]; other site 710686006107 PHB binding site; other site 710686006108 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686006109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686006110 DNA-binding site [nucleotide binding]; DNA binding site 710686006111 FCD domain; Region: FCD; pfam07729 710686006112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006113 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710686006114 substrate binding site [chemical binding]; other site 710686006115 oxyanion hole (OAH) forming residues; other site 710686006116 trimer interface [polypeptide binding]; other site 710686006117 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686006118 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710686006119 dimer interface [polypeptide binding]; other site 710686006120 active site 710686006121 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710686006122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006123 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686006124 enoyl-CoA hydratase; Provisional; Region: PRK08252 710686006125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006126 substrate binding site [chemical binding]; other site 710686006127 oxyanion hole (OAH) forming residues; other site 710686006128 trimer interface [polypeptide binding]; other site 710686006129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006130 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686006131 NAD(P) binding site [chemical binding]; other site 710686006132 active site 710686006133 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710686006134 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710686006135 active site 710686006136 inhibitor site; inhibition site 710686006137 dimer interface [polypeptide binding]; other site 710686006138 catalytic residue [active] 710686006139 enoyl-CoA hydratase; Provisional; Region: PRK06210 710686006140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006141 substrate binding site [chemical binding]; other site 710686006142 oxyanion hole (OAH) forming residues; other site 710686006143 trimer interface [polypeptide binding]; other site 710686006144 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686006145 acyl-CoA synthetase; Validated; Region: PRK07798 710686006146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006147 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710686006148 acyl-activating enzyme (AAE) consensus motif; other site 710686006149 acyl-activating enzyme (AAE) consensus motif; other site 710686006150 putative AMP binding site [chemical binding]; other site 710686006151 putative active site [active] 710686006152 putative CoA binding site [chemical binding]; other site 710686006153 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686006154 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710686006155 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686006156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006157 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686006158 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006159 active site 710686006160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686006161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006162 S-adenosylmethionine binding site [chemical binding]; other site 710686006163 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710686006164 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686006165 active site 710686006166 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686006167 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686006168 YacP-like NYN domain; Region: NYN_YacP; cl01491 710686006169 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686006170 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686006171 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710686006172 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710686006173 NAD binding site [chemical binding]; other site 710686006174 catalytic residues [active] 710686006175 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006176 Cytochrome P450; Region: p450; cl12078 710686006177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006178 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686006179 NAD(P) binding site [chemical binding]; other site 710686006180 active site 710686006181 acyl-CoA synthetase; Validated; Region: PRK07798 710686006182 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006183 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710686006184 acyl-activating enzyme (AAE) consensus motif; other site 710686006185 putative AMP binding site [chemical binding]; other site 710686006186 putative active site [active] 710686006187 putative CoA binding site [chemical binding]; other site 710686006188 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686006189 CoenzymeA binding site [chemical binding]; other site 710686006190 subunit interaction site [polypeptide binding]; other site 710686006191 PHB binding site; other site 710686006192 Isochorismatase family; Region: Isochorismatase; pfam00857 710686006193 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710686006194 catalytic triad [active] 710686006195 conserved cis-peptide bond; other site 710686006196 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 710686006197 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 710686006198 homodimer interface [polypeptide binding]; other site 710686006199 putative substrate binding pocket [chemical binding]; other site 710686006200 diiron center [ion binding]; other site 710686006201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006203 Ecdysteroid kinase; Region: EcKinase; cl17738 710686006204 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686006205 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 710686006206 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686006207 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686006208 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710686006209 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686006210 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686006211 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 710686006212 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686006213 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006214 Cytochrome P450; Region: p450; cl12078 710686006215 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686006216 Protein of unknown function (DUF466); Region: DUF466; pfam04328 710686006217 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 710686006218 Carbon starvation protein CstA; Region: CstA; pfam02554 710686006219 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 710686006220 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 710686006221 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 710686006222 active site 710686006223 DNA binding site [nucleotide binding] 710686006224 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 710686006225 DNA binding site [nucleotide binding] 710686006226 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710686006227 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710686006228 Moco binding site; other site 710686006229 metal coordination site [ion binding]; other site 710686006230 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006232 NAD(P) binding site [chemical binding]; other site 710686006233 active site 710686006234 pyruvate dehydrogenase; Provisional; Region: PRK09124 710686006235 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 710686006236 PYR/PP interface [polypeptide binding]; other site 710686006237 dimer interface [polypeptide binding]; other site 710686006238 tetramer interface [polypeptide binding]; other site 710686006239 TPP binding site [chemical binding]; other site 710686006240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686006241 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 710686006242 TPP-binding site [chemical binding]; other site 710686006243 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710686006244 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686006245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686006246 dimerization interface [polypeptide binding]; other site 710686006247 putative DNA binding site [nucleotide binding]; other site 710686006248 putative Zn2+ binding site [ion binding]; other site 710686006249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006250 S-adenosylmethionine binding site [chemical binding]; other site 710686006251 Phosphotransferase enzyme family; Region: APH; pfam01636 710686006252 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686006253 putative active site [active] 710686006254 putative substrate binding site [chemical binding]; other site 710686006255 ATP binding site [chemical binding]; other site 710686006256 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710686006257 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710686006258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006259 Cytochrome P450; Region: p450; cl12078 710686006260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006262 short chain dehydrogenase; Provisional; Region: PRK07832 710686006263 classical (c) SDRs; Region: SDR_c; cd05233 710686006264 NAD(P) binding site [chemical binding]; other site 710686006265 active site 710686006266 Predicted ATPase [General function prediction only]; Region: COG4637 710686006267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686006268 Walker A/P-loop; other site 710686006269 ATP binding site [chemical binding]; other site 710686006270 DNA polymerase IV; Validated; Region: PRK03352 710686006271 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710686006272 active site 710686006273 DNA binding site [nucleotide binding] 710686006274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006275 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686006276 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710686006278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006279 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 710686006280 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710686006281 catalytic residues [active] 710686006282 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 710686006283 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 710686006284 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 710686006285 Class I ribonucleotide reductase; Region: RNR_I; cd01679 710686006286 active site 710686006287 dimer interface [polypeptide binding]; other site 710686006288 catalytic residues [active] 710686006289 effector binding site; other site 710686006290 R2 peptide binding site; other site 710686006291 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710686006292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006294 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686006295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686006296 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 710686006297 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 710686006298 dimer interface [polypeptide binding]; other site 710686006299 putative radical transfer pathway; other site 710686006300 diiron center [ion binding]; other site 710686006301 tyrosyl radical; other site 710686006302 CsbD-like; Region: CsbD; pfam05532 710686006303 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686006304 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686006305 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 710686006306 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 710686006307 Amino acid permease; Region: AA_permease; pfam00324 710686006308 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686006309 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 710686006310 putative NAD(P) binding site [chemical binding]; other site 710686006311 putative substrate binding site [chemical binding]; other site 710686006312 catalytic Zn binding site [ion binding]; other site 710686006313 structural Zn binding site [ion binding]; other site 710686006314 dimer interface [polypeptide binding]; other site 710686006315 YCII-related domain; Region: YCII; cl00999 710686006316 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 710686006317 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710686006318 siderophore binding site; other site 710686006319 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710686006320 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710686006321 D-pathway; other site 710686006322 Putative ubiquinol binding site [chemical binding]; other site 710686006323 Low-spin heme (heme b) binding site [chemical binding]; other site 710686006324 Putative water exit pathway; other site 710686006325 Binuclear center (heme o3/CuB) [ion binding]; other site 710686006326 K-pathway; other site 710686006327 Putative proton exit pathway; other site 710686006328 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 710686006329 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 710686006330 phosphoserine phosphatase SerB; Region: serB; TIGR00338 710686006331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686006332 motif II; other site 710686006333 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 710686006334 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 710686006335 putative active site [active] 710686006336 Zn binding site [ion binding]; other site 710686006337 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710686006338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686006339 DNA-binding site [nucleotide binding]; DNA binding site 710686006340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686006341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686006342 homodimer interface [polypeptide binding]; other site 710686006343 catalytic residue [active] 710686006344 Predicted membrane protein [Function unknown]; Region: COG2364 710686006345 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710686006346 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 710686006347 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 710686006348 active site 710686006349 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710686006350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686006351 Walker A/P-loop; other site 710686006352 ATP binding site [chemical binding]; other site 710686006353 Q-loop/lid; other site 710686006354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 710686006355 ABC transporter signature motif; other site 710686006356 ABC transporter signature motif; other site 710686006357 Walker B; other site 710686006358 Walker B; other site 710686006359 D-loop; other site 710686006360 H-loop/switch region; other site 710686006361 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686006362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686006363 substrate binding site [chemical binding]; other site 710686006364 oxyanion hole (OAH) forming residues; other site 710686006365 trimer interface [polypeptide binding]; other site 710686006366 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686006367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006368 S-adenosylmethionine binding site [chemical binding]; other site 710686006369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686006370 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 710686006371 FOG: WD40-like repeat [Function unknown]; Region: COG1520 710686006372 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 710686006373 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 710686006374 trimer interface [polypeptide binding]; other site 710686006375 active site 710686006376 substrate binding site [chemical binding]; other site 710686006377 CoA binding site [chemical binding]; other site 710686006378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686006379 dimerization interface [polypeptide binding]; other site 710686006380 putative DNA binding site [nucleotide binding]; other site 710686006381 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686006382 putative Zn2+ binding site [ion binding]; other site 710686006383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686006384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686006385 putative substrate translocation pore; other site 710686006386 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710686006387 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710686006388 putative dimer interface [polypeptide binding]; other site 710686006389 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686006390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686006391 Uncharacterized conserved protein [Function unknown]; Region: COG1543 710686006392 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 710686006393 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 710686006394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006395 S-adenosylmethionine binding site [chemical binding]; other site 710686006396 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 710686006397 Ligand binding site [chemical binding]; other site 710686006398 Electron transfer flavoprotein domain; Region: ETF; pfam01012 710686006399 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 710686006400 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 710686006401 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 710686006402 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 710686006403 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686006404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686006405 putative acyl-acceptor binding pocket; other site 710686006406 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 710686006407 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 710686006408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686006409 catalytic residue [active] 710686006410 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710686006411 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 710686006412 Ligand Binding Site [chemical binding]; other site 710686006413 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686006414 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 710686006415 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 710686006416 putative hydrophobic ligand binding site [chemical binding]; other site 710686006417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686006418 dimerization interface [polypeptide binding]; other site 710686006419 putative DNA binding site [nucleotide binding]; other site 710686006420 putative Zn2+ binding site [ion binding]; other site 710686006421 4-coumarate--CoA ligase; Region: PLN02246 710686006422 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 710686006423 acyl-activating enzyme (AAE) consensus motif; other site 710686006424 active site 710686006425 putative CoA binding site [chemical binding]; other site 710686006426 AMP binding site [chemical binding]; other site 710686006427 Protein of unknown function (DUF419); Region: DUF419; pfam04237 710686006428 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 710686006429 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710686006430 nucleotide binding pocket [chemical binding]; other site 710686006431 K-X-D-G motif; other site 710686006432 catalytic site [active] 710686006433 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710686006434 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710686006435 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 710686006436 Dimer interface [polypeptide binding]; other site 710686006437 BRCT sequence motif; other site 710686006438 spermidine synthase; Provisional; Region: PRK03612 710686006439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006440 S-adenosylmethionine binding site [chemical binding]; other site 710686006441 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 710686006442 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 710686006443 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 710686006444 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 710686006445 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 710686006446 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 710686006447 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710686006448 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 710686006449 6-phosphofructokinase; Provisional; Region: PRK03202 710686006450 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 710686006451 active site 710686006452 ADP/pyrophosphate binding site [chemical binding]; other site 710686006453 dimerization interface [polypeptide binding]; other site 710686006454 allosteric effector site; other site 710686006455 fructose-1,6-bisphosphate binding site; other site 710686006456 DoxX-like family; Region: DoxX_2; pfam13564 710686006457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006458 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710686006459 NAD(P) binding site [chemical binding]; other site 710686006460 active site 710686006461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686006462 MarR family; Region: MarR_2; pfam12802 710686006463 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710686006464 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710686006465 GatB domain; Region: GatB_Yqey; smart00845 710686006466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006468 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710686006469 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710686006470 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710686006471 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 710686006472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686006473 PYR/PP interface [polypeptide binding]; other site 710686006474 dimer interface [polypeptide binding]; other site 710686006475 TPP binding site [chemical binding]; other site 710686006476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686006477 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 710686006478 TPP-binding site [chemical binding]; other site 710686006479 dimer interface [polypeptide binding]; other site 710686006480 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 710686006481 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 710686006482 putative valine binding site [chemical binding]; other site 710686006483 dimer interface [polypeptide binding]; other site 710686006484 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 710686006485 ketol-acid reductoisomerase; Provisional; Region: PRK05479 710686006486 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 710686006487 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 710686006488 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710686006489 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686006490 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710686006491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686006492 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 710686006493 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 710686006494 ligand binding site [chemical binding]; other site 710686006495 NAD binding site [chemical binding]; other site 710686006496 dimerization interface [polypeptide binding]; other site 710686006497 catalytic site [active] 710686006498 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 710686006499 putative L-serine binding site [chemical binding]; other site 710686006500 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 710686006501 tartrate dehydrogenase; Region: TTC; TIGR02089 710686006502 Phosphoesterase family; Region: Phosphoesterase; pfam04185 710686006503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686006504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686006505 putative substrate translocation pore; other site 710686006506 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 710686006507 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710686006508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710686006509 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710686006510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686006511 active site 710686006512 HIGH motif; other site 710686006513 nucleotide binding site [chemical binding]; other site 710686006514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710686006515 active site 710686006516 KMSKS motif; other site 710686006517 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686006518 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686006519 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686006520 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 710686006521 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 710686006522 substrate binding site [chemical binding]; other site 710686006523 ligand binding site [chemical binding]; other site 710686006524 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 710686006525 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 710686006526 substrate binding site [chemical binding]; other site 710686006527 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710686006528 IHF - DNA interface [nucleotide binding]; other site 710686006529 IHF dimer interface [polypeptide binding]; other site 710686006530 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710686006531 active site 710686006532 Ap6A binding site [chemical binding]; other site 710686006533 nudix motif; other site 710686006534 metal binding site [ion binding]; metal-binding site 710686006535 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686006536 catalytic core [active] 710686006537 polyphosphate kinase; Provisional; Region: PRK05443 710686006538 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 710686006539 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 710686006540 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 710686006541 putative domain interface [polypeptide binding]; other site 710686006542 putative active site [active] 710686006543 catalytic site [active] 710686006544 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710686006545 putative active site [active] 710686006546 catalytic site [active] 710686006547 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 710686006548 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 710686006549 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710686006550 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710686006551 cystathionine gamma-lyase; Validated; Region: PRK07582 710686006552 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686006553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686006554 catalytic residue [active] 710686006555 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 710686006556 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 710686006557 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 710686006558 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 710686006559 AsnC family; Region: AsnC_trans_reg; pfam01037 710686006560 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710686006561 thiamine monophosphate kinase; Provisional; Region: PRK05731 710686006562 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 710686006563 ATP binding site [chemical binding]; other site 710686006564 dimerization interface [polypeptide binding]; other site 710686006565 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 710686006566 ligand binding site [chemical binding]; other site 710686006567 active site 710686006568 UGI interface [polypeptide binding]; other site 710686006569 catalytic site [active] 710686006570 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710686006571 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710686006572 DAK2 domain; Region: Dak2; pfam02734 710686006573 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 710686006574 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710686006575 generic binding surface II; other site 710686006576 ssDNA binding site; other site 710686006577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686006578 ATP binding site [chemical binding]; other site 710686006579 putative Mg++ binding site [ion binding]; other site 710686006580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686006581 nucleotide binding region [chemical binding]; other site 710686006582 ATP-binding site [chemical binding]; other site 710686006583 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710686006584 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686006585 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686006586 active site 710686006587 catalytic tetrad [active] 710686006588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686006589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686006590 active site 710686006591 catalytic tetrad [active] 710686006592 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686006593 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710686006594 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 710686006595 catalytic residues [active] 710686006596 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 710686006597 putative active site [active] 710686006598 redox center [active] 710686006599 pyruvate carboxylase; Reviewed; Region: PRK12999 710686006600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686006601 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686006602 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710686006603 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 710686006604 active site 710686006605 catalytic residues [active] 710686006606 metal binding site [ion binding]; metal-binding site 710686006607 homodimer binding site [polypeptide binding]; other site 710686006608 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686006609 carboxyltransferase (CT) interaction site; other site 710686006610 biotinylation site [posttranslational modification]; other site 710686006611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006612 S-adenosylmethionine binding site [chemical binding]; other site 710686006613 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 710686006614 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 710686006615 active site 710686006616 (T/H)XGH motif; other site 710686006617 Hemerythrin-like domain; Region: Hr-like; cd12108 710686006618 Fe binding site [ion binding]; other site 710686006619 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710686006620 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 710686006621 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 710686006622 ribonuclease III; Reviewed; Region: rnc; PRK00102 710686006623 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 710686006624 dimerization interface [polypeptide binding]; other site 710686006625 active site 710686006626 metal binding site [ion binding]; metal-binding site 710686006627 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 710686006628 dsRNA binding site [nucleotide binding]; other site 710686006629 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710686006630 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710686006631 DNA binding site [nucleotide binding] 710686006632 catalytic residue [active] 710686006633 H2TH interface [polypeptide binding]; other site 710686006634 putative catalytic residues [active] 710686006635 turnover-facilitating residue; other site 710686006636 intercalation triad [nucleotide binding]; other site 710686006637 8OG recognition residue [nucleotide binding]; other site 710686006638 putative reading head residues; other site 710686006639 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710686006640 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710686006641 putative acyl transferase; Provisional; Region: PRK10502 710686006642 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 710686006643 acylphosphatase; Provisional; Region: PRK14422 710686006644 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710686006645 AAA domain; Region: AAA_23; pfam13476 710686006646 Walker A/P-loop; other site 710686006647 ATP binding site [chemical binding]; other site 710686006648 Q-loop/lid; other site 710686006649 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710686006650 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 710686006651 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710686006652 ABC transporter signature motif; other site 710686006653 Walker B; other site 710686006654 D-loop; other site 710686006655 H-loop/switch region; other site 710686006656 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 710686006657 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 710686006658 homotetramer interface [polypeptide binding]; other site 710686006659 FMN binding site [chemical binding]; other site 710686006660 homodimer contacts [polypeptide binding]; other site 710686006661 putative active site [active] 710686006662 putative substrate binding site [chemical binding]; other site 710686006663 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 710686006664 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710686006665 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686006666 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710686006667 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 710686006668 Nitrogen regulatory protein P-II; Region: P-II; smart00938 710686006669 PII uridylyl-transferase; Provisional; Region: PRK03381 710686006670 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710686006671 metal binding triad; other site 710686006672 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710686006673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686006674 Zn2+ binding site [ion binding]; other site 710686006675 Mg2+ binding site [ion binding]; other site 710686006676 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710686006677 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710686006678 signal recognition particle protein; Provisional; Region: PRK10867 710686006679 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710686006680 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710686006681 P loop; other site 710686006682 GTP binding site [chemical binding]; other site 710686006683 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 710686006684 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710686006685 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710686006686 Amidohydrolase; Region: Amidohydro_4; pfam13147 710686006687 active site 710686006688 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710686006689 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710686006690 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710686006691 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710686006692 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710686006693 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710686006694 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686006695 SnoaL-like domain; Region: SnoaL_3; pfam13474 710686006696 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 710686006697 hypothetical protein; Provisional; Region: PRK02821 710686006698 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 710686006699 G-X-X-G motif; other site 710686006700 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 710686006701 RimM N-terminal domain; Region: RimM; pfam01782 710686006702 PRC-barrel domain; Region: PRC; pfam05239 710686006703 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 710686006704 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710686006705 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 710686006706 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710686006707 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710686006708 Catalytic site [active] 710686006709 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710686006710 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 710686006711 RNA/DNA hybrid binding site [nucleotide binding]; other site 710686006712 active site 710686006713 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 710686006714 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006715 Cytochrome P450; Region: p450; cl12078 710686006716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006721 short chain dehydrogenase; Provisional; Region: PRK07791 710686006722 NAD(P) binding site [chemical binding]; other site 710686006723 active site 710686006724 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686006725 metal ion-dependent adhesion site (MIDAS); other site 710686006726 MoxR-like ATPases [General function prediction only]; Region: COG0714 710686006727 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 710686006728 Walker A motif; other site 710686006729 ATP binding site [chemical binding]; other site 710686006730 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710686006731 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710686006732 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 710686006733 ligand binding site [chemical binding]; other site 710686006734 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686006735 short chain dehydrogenase; Provisional; Region: PRK06914 710686006736 NADP binding site [chemical binding]; other site 710686006737 active site 710686006738 steroid binding site; other site 710686006739 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710686006740 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710686006741 NAD binding site [chemical binding]; other site 710686006742 catalytic residues [active] 710686006743 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006744 Cytochrome P450; Region: p450; cl12078 710686006745 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006746 Cytochrome P450; Region: p450; cl12078 710686006747 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 710686006748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686006749 catalytic residue [active] 710686006750 MarR family; Region: MarR; pfam01047 710686006751 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686006752 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686006753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686006754 Coenzyme A binding pocket [chemical binding]; other site 710686006755 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710686006756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686006757 active site 710686006758 motif I; other site 710686006759 motif II; other site 710686006760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686006761 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 710686006762 active site 710686006763 Mn binding site [ion binding]; other site 710686006764 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 710686006765 TPP-binding site [chemical binding]; other site 710686006766 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710686006767 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 710686006768 PYR/PP interface [polypeptide binding]; other site 710686006769 dimer interface [polypeptide binding]; other site 710686006770 TPP binding site [chemical binding]; other site 710686006771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686006772 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 710686006773 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686006774 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710686006775 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710686006776 active site 710686006777 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710686006778 catalytic triad [active] 710686006779 dimer interface [polypeptide binding]; other site 710686006780 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686006781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686006782 active site 710686006783 CoA binding site [chemical binding]; other site 710686006784 AMP binding site [chemical binding]; other site 710686006785 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686006786 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710686006787 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710686006788 Walker A/P-loop; other site 710686006789 ATP binding site [chemical binding]; other site 710686006790 Q-loop/lid; other site 710686006791 ABC transporter signature motif; other site 710686006792 Walker B; other site 710686006793 D-loop; other site 710686006794 H-loop/switch region; other site 710686006795 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 710686006796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686006797 dimer interface [polypeptide binding]; other site 710686006798 conserved gate region; other site 710686006799 ABC-ATPase subunit interface; other site 710686006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686006801 dimer interface [polypeptide binding]; other site 710686006802 conserved gate region; other site 710686006803 ABC-ATPase subunit interface; other site 710686006804 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 710686006805 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710686006806 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710686006807 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710686006808 hypothetical protein; Reviewed; Region: PRK12497 710686006809 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 710686006810 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710686006811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686006812 Walker A motif; other site 710686006813 ATP binding site [chemical binding]; other site 710686006814 Walker B motif; other site 710686006815 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 710686006816 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 710686006817 DNA protecting protein DprA; Region: dprA; TIGR00732 710686006818 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 710686006819 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 710686006820 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 710686006821 FAD binding pocket [chemical binding]; other site 710686006822 FAD binding motif [chemical binding]; other site 710686006823 phosphate binding motif [ion binding]; other site 710686006824 NAD binding pocket [chemical binding]; other site 710686006825 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686006826 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686006827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006828 active site 710686006829 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686006830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006832 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 710686006833 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710686006834 putative active site [active] 710686006835 putative substrate binding site [chemical binding]; other site 710686006836 putative FMN binding site [chemical binding]; other site 710686006837 putative catalytic residues [active] 710686006838 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710686006839 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710686006840 active site 710686006841 DNA binding site [nucleotide binding] 710686006842 Int/Topo IB signature motif; other site 710686006843 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710686006844 Peptidase family M23; Region: Peptidase_M23; pfam01551 710686006845 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710686006846 rRNA interaction site [nucleotide binding]; other site 710686006847 S8 interaction site; other site 710686006848 putative laminin-1 binding site; other site 710686006849 elongation factor Ts; Provisional; Region: tsf; PRK09377 710686006850 UBA/TS-N domain; Region: UBA; pfam00627 710686006851 Elongation factor TS; Region: EF_TS; pfam00889 710686006852 Elongation factor TS; Region: EF_TS; pfam00889 710686006853 amidase; Provisional; Region: PRK07869 710686006854 Amidase; Region: Amidase; pfam01425 710686006855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710686006856 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686006857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686006858 Walker A/P-loop; other site 710686006859 ATP binding site [chemical binding]; other site 710686006860 Q-loop/lid; other site 710686006861 ABC transporter signature motif; other site 710686006862 Walker B; other site 710686006863 D-loop; other site 710686006864 H-loop/switch region; other site 710686006865 Amino acid permease; Region: AA_permease_2; pfam13520 710686006866 tyramine oxidase; Provisional; Region: tynA; PRK11504 710686006867 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 710686006868 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 710686006869 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 710686006870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686006871 MarR family; Region: MarR; pfam01047 710686006872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686006873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686006874 S-adenosylmethionine binding site [chemical binding]; other site 710686006875 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 710686006876 putative nucleotide binding site [chemical binding]; other site 710686006877 uridine monophosphate binding site [chemical binding]; other site 710686006878 homohexameric interface [polypeptide binding]; other site 710686006879 ribosome recycling factor; Reviewed; Region: frr; PRK00083 710686006880 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 710686006881 hinge region; other site 710686006882 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710686006883 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710686006884 EamA-like transporter family; Region: EamA; pfam00892 710686006885 EamA-like transporter family; Region: EamA; pfam00892 710686006886 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 710686006887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686006888 FeS/SAM binding site; other site 710686006889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006891 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686006892 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686006893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006895 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006896 Cytochrome P450; Region: p450; cl12078 710686006897 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686006898 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686006899 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710686006900 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710686006901 Strictosidine synthase; Region: Str_synth; pfam03088 710686006902 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006903 Cytochrome P450; Region: p450; cl12078 710686006904 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686006905 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686006906 NAD(P) binding site [chemical binding]; other site 710686006907 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 710686006908 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686006909 classical (c) SDRs; Region: SDR_c; cd05233 710686006910 NAD(P) binding site [chemical binding]; other site 710686006911 active site 710686006912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686006913 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686006914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686006915 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686006916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006917 active site 710686006918 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686006919 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686006920 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686006921 active site 2 [active] 710686006922 active site 1 [active] 710686006923 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686006924 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686006925 DoxX-like family; Region: DoxX_2; pfam13564 710686006926 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686006927 Cytochrome P450; Region: p450; cl12078 710686006928 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 710686006929 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686006930 AMP-binding domain protein; Validated; Region: PRK07529 710686006931 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 710686006932 acyl-activating enzyme (AAE) consensus motif; other site 710686006933 putative AMP binding site [chemical binding]; other site 710686006934 putative active site [active] 710686006935 putative CoA binding site [chemical binding]; other site 710686006936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710686006937 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710686006938 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710686006939 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 710686006940 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 710686006941 putative active site [active] 710686006942 putative metal binding site [ion binding]; other site 710686006943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686006944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686006945 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710686006946 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710686006947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686006948 active site 710686006949 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710686006950 Domain of unknown function (DUF427); Region: DUF427; cl00998 710686006951 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710686006952 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686006953 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686006954 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710686006955 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 710686006956 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686006957 classical (c) SDRs; Region: SDR_c; cd05233 710686006958 NAD(P) binding site [chemical binding]; other site 710686006959 active site 710686006960 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 710686006961 DNA photolyase; Region: DNA_photolyase; pfam00875 710686006962 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 710686006963 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 710686006964 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686006965 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686006967 NAD(P) binding site [chemical binding]; other site 710686006968 active site 710686006969 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 710686006970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686006971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686006972 DNA binding residues [nucleotide binding] 710686006973 methionine sulfoxide reductase A; Provisional; Region: PRK13014 710686006974 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710686006975 SelR domain; Region: SelR; pfam01641 710686006976 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710686006977 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710686006978 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 710686006979 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686006980 catalytic residues [active] 710686006981 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 710686006982 Fasciclin domain; Region: Fasciclin; pfam02469 710686006983 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710686006984 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710686006985 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710686006986 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 710686006987 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 710686006988 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 710686006989 active site 710686006990 putative substrate binding region [chemical binding]; other site 710686006991 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710686006992 active site 710686006993 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710686006994 putative substrate binding region [chemical binding]; other site 710686006995 putative substrate binding region [chemical binding]; other site 710686006996 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710686006997 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 710686006998 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710686006999 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710686007000 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 710686007001 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 710686007002 primary dimer interface [polypeptide binding]; other site 710686007003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710686007004 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 710686007005 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710686007006 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710686007007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710686007008 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710686007009 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710686007010 active site 710686007011 cobyric acid synthase; Provisional; Region: PRK00784 710686007012 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686007013 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710686007014 catalytic triad [active] 710686007015 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710686007016 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710686007017 DNA binding site [nucleotide binding] 710686007018 domain linker motif; other site 710686007019 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710686007020 ligand binding site [chemical binding]; other site 710686007021 dimerization interface [polypeptide binding]; other site 710686007022 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710686007023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710686007024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686007025 Walker A/P-loop; other site 710686007026 ATP binding site [chemical binding]; other site 710686007027 Q-loop/lid; other site 710686007028 ABC transporter signature motif; other site 710686007029 Walker B; other site 710686007030 D-loop; other site 710686007031 H-loop/switch region; other site 710686007032 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710686007033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710686007034 TM-ABC transporter signature motif; other site 710686007035 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 710686007036 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 710686007037 putative ligand binding site [chemical binding]; other site 710686007038 short chain dehydrogenase; Provisional; Region: PRK07060 710686007039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686007040 NAD(P) binding site [chemical binding]; other site 710686007041 active site 710686007042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007043 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 710686007044 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686007045 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686007046 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 710686007047 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710686007048 active site 710686007049 dimer interface [polypeptide binding]; other site 710686007050 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710686007051 Ligand Binding Site [chemical binding]; other site 710686007052 Molecular Tunnel; other site 710686007053 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 710686007054 ethanolamine permease; Region: 2A0305; TIGR00908 710686007055 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710686007056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686007057 nucleotide binding site [chemical binding]; other site 710686007058 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710686007059 active site 710686007060 NAD binding site [chemical binding]; other site 710686007061 metal binding site [ion binding]; metal-binding site 710686007062 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686007063 phosphate binding site [ion binding]; other site 710686007064 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686007065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686007066 DNA-binding site [nucleotide binding]; DNA binding site 710686007067 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710686007068 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710686007069 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710686007070 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686007071 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 710686007072 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 710686007073 catalytic triad [active] 710686007074 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686007075 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686007076 NAD(P) binding site [chemical binding]; other site 710686007077 catalytic residues [active] 710686007078 short chain dehydrogenase; Provisional; Region: PRK06057 710686007079 classical (c) SDRs; Region: SDR_c; cd05233 710686007080 NAD(P) binding site [chemical binding]; other site 710686007081 active site 710686007082 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686007083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686007084 DNA-binding site [nucleotide binding]; DNA binding site 710686007085 FCD domain; Region: FCD; pfam07729 710686007086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686007087 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 710686007088 dimer interface [polypeptide binding]; other site 710686007089 putative metal binding site [ion binding]; other site 710686007090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007091 dimerization interface [polypeptide binding]; other site 710686007092 putative DNA binding site [nucleotide binding]; other site 710686007093 putative Zn2+ binding site [ion binding]; other site 710686007094 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686007095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686007096 DNA-binding site [nucleotide binding]; DNA binding site 710686007097 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710686007098 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710686007099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686007100 motif II; other site 710686007101 Phosphotransferase enzyme family; Region: APH; pfam01636 710686007102 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 710686007103 active site 710686007104 ATP binding site [chemical binding]; other site 710686007105 substrate binding site [chemical binding]; other site 710686007106 dimer interface [polypeptide binding]; other site 710686007107 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686007108 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710686007109 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710686007110 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 710686007111 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710686007112 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 710686007113 mycothione reductase; Reviewed; Region: PRK07846 710686007114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686007115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686007116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686007117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007118 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686007119 malate:quinone oxidoreductase; Validated; Region: PRK05257 710686007120 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 710686007121 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 710686007122 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 710686007123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710686007124 Walker A motif; other site 710686007125 ATP binding site [chemical binding]; other site 710686007126 Walker B motif; other site 710686007127 arginine finger; other site 710686007128 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 710686007129 metal ion-dependent adhesion site (MIDAS); other site 710686007130 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 710686007131 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 710686007132 Walker A motif; other site 710686007133 homodimer interface [polypeptide binding]; other site 710686007134 ATP binding site [chemical binding]; other site 710686007135 hydroxycobalamin binding site [chemical binding]; other site 710686007136 Walker B motif; other site 710686007137 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 710686007138 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710686007139 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 710686007140 catalytic triad [active] 710686007141 siroheme synthase; Provisional; Region: cysG; PRK10637 710686007142 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 710686007143 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 710686007144 homodimer interface [polypeptide binding]; other site 710686007145 active site 710686007146 SAM binding site [chemical binding]; other site 710686007147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686007148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686007149 putative substrate translocation pore; other site 710686007150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686007151 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710686007152 prolyl-tRNA synthetase; Provisional; Region: PRK09194 710686007153 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 710686007154 dimer interface [polypeptide binding]; other site 710686007155 motif 1; other site 710686007156 active site 710686007157 motif 2; other site 710686007158 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 710686007159 putative deacylase active site [active] 710686007160 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710686007161 active site 710686007162 motif 3; other site 710686007163 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 710686007164 anticodon binding site; other site 710686007165 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710686007166 dinuclear metal binding motif [ion binding]; other site 710686007167 ribosome maturation protein RimP; Reviewed; Region: PRK00092 710686007168 Sm and related proteins; Region: Sm_like; cl00259 710686007169 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 710686007170 putative oligomer interface [polypeptide binding]; other site 710686007171 putative RNA binding site [nucleotide binding]; other site 710686007172 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 710686007173 NusA N-terminal domain; Region: NusA_N; pfam08529 710686007174 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 710686007175 RNA binding site [nucleotide binding]; other site 710686007176 homodimer interface [polypeptide binding]; other site 710686007177 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710686007178 G-X-X-G motif; other site 710686007179 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710686007180 G-X-X-G motif; other site 710686007181 Protein of unknown function (DUF448); Region: DUF448; pfam04296 710686007182 putative RNA binding cleft [nucleotide binding]; other site 710686007183 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710686007184 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710686007185 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 710686007186 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 710686007187 G1 box; other site 710686007188 putative GEF interaction site [polypeptide binding]; other site 710686007189 GTP/Mg2+ binding site [chemical binding]; other site 710686007190 Switch I region; other site 710686007191 G2 box; other site 710686007192 G3 box; other site 710686007193 Switch II region; other site 710686007194 G4 box; other site 710686007195 G5 box; other site 710686007196 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 710686007197 Translation-initiation factor 2; Region: IF-2; pfam11987 710686007198 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 710686007199 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 710686007200 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710686007201 DHH family; Region: DHH; pfam01368 710686007202 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 710686007203 putative efflux protein, MATE family; Region: matE; TIGR00797 710686007204 enoyl-CoA hydratase; Provisional; Region: PRK06190 710686007205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686007206 substrate binding site [chemical binding]; other site 710686007207 oxyanion hole (OAH) forming residues; other site 710686007208 trimer interface [polypeptide binding]; other site 710686007209 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 710686007210 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 710686007211 Predicted acyl esterases [General function prediction only]; Region: COG2936 710686007212 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710686007213 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 710686007214 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710686007215 active site 710686007216 metal binding site [ion binding]; metal-binding site 710686007217 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 710686007218 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 710686007219 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 710686007220 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 710686007221 RNA binding site [nucleotide binding]; other site 710686007222 active site 710686007223 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 710686007224 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 710686007225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007226 putative DNA binding site [nucleotide binding]; other site 710686007227 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710686007228 FeoA domain; Region: FeoA; pfam04023 710686007229 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 710686007230 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710686007231 active site 710686007232 Riboflavin kinase; Region: Flavokinase; pfam01687 710686007233 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 710686007234 16S/18S rRNA binding site [nucleotide binding]; other site 710686007235 S13e-L30e interaction site [polypeptide binding]; other site 710686007236 25S rRNA binding site [nucleotide binding]; other site 710686007237 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 710686007238 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 710686007239 oligomer interface [polypeptide binding]; other site 710686007240 RNA binding site [nucleotide binding]; other site 710686007241 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 710686007242 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 710686007243 RNase E interface [polypeptide binding]; other site 710686007244 trimer interface [polypeptide binding]; other site 710686007245 active site 710686007246 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 710686007247 putative nucleic acid binding region [nucleotide binding]; other site 710686007248 G-X-X-G motif; other site 710686007249 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 710686007250 RNA binding site [nucleotide binding]; other site 710686007251 domain interface; other site 710686007252 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 710686007253 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 710686007254 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 710686007255 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710686007256 Response regulator receiver domain; Region: Response_reg; pfam00072 710686007257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 710686007258 active site 710686007259 dimerization interface [polypeptide binding]; other site 710686007260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710686007261 DNA binding residues [nucleotide binding] 710686007262 dimerization interface [polypeptide binding]; other site 710686007263 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710686007264 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 710686007265 hexamer interface [polypeptide binding]; other site 710686007266 ligand binding site [chemical binding]; other site 710686007267 putative active site [active] 710686007268 NAD(P) binding site [chemical binding]; other site 710686007269 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710686007270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007271 putative DNA binding site [nucleotide binding]; other site 710686007272 putative Zn2+ binding site [ion binding]; other site 710686007273 AsnC family; Region: AsnC_trans_reg; pfam01037 710686007274 dihydrodipicolinate reductase; Provisional; Region: PRK00048 710686007275 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686007276 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 710686007277 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710686007278 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686007279 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710686007280 PhoU domain; Region: PhoU; pfam01895 710686007281 PhoU domain; Region: PhoU; pfam01895 710686007282 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710686007283 Dienelactone hydrolase family; Region: DLH; pfam01738 710686007284 thymidylate synthase; Reviewed; Region: thyA; PRK01827 710686007285 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710686007286 dimerization interface [polypeptide binding]; other site 710686007287 active site 710686007288 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710686007289 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710686007290 folate binding site [chemical binding]; other site 710686007291 NADP+ binding site [chemical binding]; other site 710686007292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 710686007293 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710686007294 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686007295 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 710686007296 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686007297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686007298 DNA-binding site [nucleotide binding]; DNA binding site 710686007299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686007300 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 710686007301 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710686007302 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 710686007303 dimer interface [polypeptide binding]; other site 710686007304 active site 710686007305 catalytic residue [active] 710686007306 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710686007307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686007308 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710686007309 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686007310 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710686007311 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710686007312 classical (c) SDRs; Region: SDR_c; cd05233 710686007313 NAD(P) binding site [chemical binding]; other site 710686007314 active site 710686007315 Uncharacterized conserved protein [Function unknown]; Region: COG1359 710686007316 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710686007317 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 710686007318 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 710686007319 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686007320 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 710686007321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686007322 Coenzyme A binding pocket [chemical binding]; other site 710686007323 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710686007324 Competence-damaged protein; Region: CinA; pfam02464 710686007325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686007326 non-specific DNA binding site [nucleotide binding]; other site 710686007327 salt bridge; other site 710686007328 sequence-specific DNA binding site [nucleotide binding]; other site 710686007329 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710686007330 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686007331 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686007332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710686007333 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 710686007334 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710686007335 active site 710686007336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686007337 non-specific DNA binding site [nucleotide binding]; other site 710686007338 salt bridge; other site 710686007339 sequence-specific DNA binding site [nucleotide binding]; other site 710686007340 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 710686007341 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 710686007342 HupF/HypC family; Region: HupF_HypC; pfam01455 710686007343 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 710686007344 dimerization interface [polypeptide binding]; other site 710686007345 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 710686007346 ATP binding site [chemical binding]; other site 710686007347 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 710686007348 dimer interface [polypeptide binding]; other site 710686007349 active site 710686007350 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 710686007351 HupF/HypC family; Region: HupF_HypC; cl00394 710686007352 Acylphosphatase; Region: Acylphosphatase; pfam00708 710686007353 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 710686007354 HypF finger; Region: zf-HYPF; pfam07503 710686007355 HypF finger; Region: zf-HYPF; pfam07503 710686007356 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 710686007357 HupF/HypC family; Region: HupF_HypC; pfam01455 710686007358 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 710686007359 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 710686007360 nickel binding site [ion binding]; other site 710686007361 NifU-like domain; Region: NifU; cl00484 710686007362 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686007363 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 710686007364 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 710686007365 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 710686007366 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686007367 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 710686007368 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 710686007369 recombinase A; Provisional; Region: recA; PRK09354 710686007370 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710686007371 hexamer interface [polypeptide binding]; other site 710686007372 Walker A motif; other site 710686007373 ATP binding site [chemical binding]; other site 710686007374 Walker B motif; other site 710686007375 recombination regulator RecX; Reviewed; Region: recX; PRK00117 710686007376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710686007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686007378 dimer interface [polypeptide binding]; other site 710686007379 conserved gate region; other site 710686007380 putative PBP binding loops; other site 710686007381 ABC-ATPase subunit interface; other site 710686007382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686007383 dimer interface [polypeptide binding]; other site 710686007384 conserved gate region; other site 710686007385 putative PBP binding loops; other site 710686007386 ABC-ATPase subunit interface; other site 710686007387 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686007388 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686007389 substrate binding pocket [chemical binding]; other site 710686007390 membrane-bound complex binding site; other site 710686007391 hinge residues; other site 710686007392 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710686007393 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710686007394 Walker A/P-loop; other site 710686007395 ATP binding site [chemical binding]; other site 710686007396 Q-loop/lid; other site 710686007397 ABC transporter signature motif; other site 710686007398 Walker B; other site 710686007399 D-loop; other site 710686007400 H-loop/switch region; other site 710686007401 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 710686007402 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 710686007403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686007404 FeS/SAM binding site; other site 710686007405 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710686007406 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710686007407 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710686007408 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710686007409 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 710686007410 active site 710686007411 metal binding site [ion binding]; metal-binding site 710686007412 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 710686007413 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 710686007414 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 710686007415 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710686007416 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710686007417 GTPases [General function prediction only]; Region: HflX; COG2262 710686007418 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 710686007419 HflX GTPase family; Region: HflX; cd01878 710686007420 G1 box; other site 710686007421 GTP/Mg2+ binding site [chemical binding]; other site 710686007422 Switch I region; other site 710686007423 G2 box; other site 710686007424 G3 box; other site 710686007425 Switch II region; other site 710686007426 G4 box; other site 710686007427 G5 box; other site 710686007428 amidase; Validated; Region: PRK06565 710686007429 Amidase; Region: Amidase; cl11426 710686007430 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 710686007431 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 710686007432 molybdopterin cofactor binding site [chemical binding]; other site 710686007433 substrate binding site [chemical binding]; other site 710686007434 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 710686007435 molybdopterin cofactor binding site; other site 710686007436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686007437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686007438 active site 710686007439 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710686007440 LGFP repeat; Region: LGFP; pfam08310 710686007441 LGFP repeat; Region: LGFP; pfam08310 710686007442 LGFP repeat; Region: LGFP; pfam08310 710686007443 LGFP repeat; Region: LGFP; pfam08310 710686007444 LexA repressor; Validated; Region: PRK00215 710686007445 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 710686007446 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 710686007447 Catalytic site [active] 710686007448 LysM domain; Region: LysM; pfam01476 710686007449 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 710686007450 ATP cone domain; Region: ATP-cone; pfam03477 710686007451 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 710686007452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007453 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686007454 PAC2 family; Region: PAC2; pfam09754 710686007455 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 710686007456 active site 710686007457 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 710686007458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686007459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686007460 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686007461 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710686007462 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710686007463 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 710686007464 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710686007465 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 710686007466 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710686007467 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 710686007468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686007469 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710686007470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686007471 DNA binding residues [nucleotide binding] 710686007472 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 710686007473 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 710686007474 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 710686007475 Protein of unknown function (DUF952); Region: DUF952; pfam06108 710686007476 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 710686007477 homotrimer interaction site [polypeptide binding]; other site 710686007478 putative active site [active] 710686007479 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710686007480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686007481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 710686007482 putative Zn2+ binding site [ion binding]; other site 710686007483 putative DNA binding site [nucleotide binding]; other site 710686007484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686007485 S-adenosylmethionine binding site [chemical binding]; other site 710686007486 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710686007487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686007488 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710686007489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686007490 DNA binding residues [nucleotide binding] 710686007491 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710686007492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686007493 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 710686007494 active site 710686007495 dimerization interface [polypeptide binding]; other site 710686007496 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710686007497 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710686007498 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710686007499 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 710686007500 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710686007501 trimer interface [polypeptide binding]; other site 710686007502 active site 710686007503 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 710686007504 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710686007505 generic binding surface II; other site 710686007506 ssDNA binding site; other site 710686007507 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 710686007508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686007509 putative substrate translocation pore; other site 710686007510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686007511 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710686007512 TrkA-N domain; Region: TrkA_N; pfam02254 710686007513 TrkA-C domain; Region: TrkA_C; pfam02080 710686007514 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710686007515 TrkA-N domain; Region: TrkA_N; pfam02254 710686007516 TrkA-C domain; Region: TrkA_C; pfam02080 710686007517 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686007518 TRAM domain; Region: TRAM; cl01282 710686007519 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 710686007520 hydroperoxidase II; Provisional; Region: katE; PRK11249 710686007521 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 710686007522 tetramer interface [polypeptide binding]; other site 710686007523 heme binding pocket [chemical binding]; other site 710686007524 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 710686007525 domain interactions; other site 710686007526 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 710686007527 putative hydrophobic ligand binding site [chemical binding]; other site 710686007528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007529 dimerization interface [polypeptide binding]; other site 710686007530 putative DNA binding site [nucleotide binding]; other site 710686007531 putative Zn2+ binding site [ion binding]; other site 710686007532 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686007533 TIGR03086 family protein; Region: TIGR03086 710686007534 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686007535 hydrophobic ligand binding site; other site 710686007536 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710686007537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007538 putative DNA binding site [nucleotide binding]; other site 710686007539 putative Zn2+ binding site [ion binding]; other site 710686007540 AsnC family; Region: AsnC_trans_reg; pfam01037 710686007541 hydrophobic ligand binding site; other site 710686007542 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686007543 TIGR03085 family protein; Region: TIGR03085 710686007544 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710686007545 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 710686007546 transmembrane helices; other site 710686007547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710686007548 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 710686007549 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710686007550 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 710686007551 TPP-binding site; other site 710686007552 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710686007553 PYR/PP interface [polypeptide binding]; other site 710686007554 dimer interface [polypeptide binding]; other site 710686007555 TPP binding site [chemical binding]; other site 710686007556 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686007557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007558 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 710686007559 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 710686007560 catalytic site [active] 710686007561 putative active site [active] 710686007562 putative substrate binding site [chemical binding]; other site 710686007563 Helicase and RNase D C-terminal; Region: HRDC; smart00341 710686007564 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 710686007565 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 710686007566 substrate binding site [chemical binding]; other site 710686007567 active site 710686007568 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 710686007569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686007570 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 710686007571 malate dehydrogenase; Provisional; Region: PRK13529 710686007572 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710686007573 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 710686007574 NAD(P) binding pocket [chemical binding]; other site 710686007575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686007576 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686007577 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686007578 iron-sulfur cluster [ion binding]; other site 710686007579 [2Fe-2S] cluster binding site [ion binding]; other site 710686007580 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686007581 hydrophobic ligand binding site; other site 710686007582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686007583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686007584 acetoin reductases; Region: 23BDH; TIGR02415 710686007585 classical (c) SDRs; Region: SDR_c; cd05233 710686007586 NAD(P) binding site [chemical binding]; other site 710686007587 active site 710686007588 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686007589 classical (c) SDRs; Region: SDR_c; cd05233 710686007590 NAD(P) binding site [chemical binding]; other site 710686007591 active site 710686007592 Creatinine amidohydrolase; Region: Creatininase; pfam02633 710686007593 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710686007594 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710686007595 active site 710686007596 metal binding site [ion binding]; metal-binding site 710686007597 Amino acid permease; Region: AA_permease_2; pfam13520 710686007598 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 710686007599 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 710686007600 NAD binding site [chemical binding]; other site 710686007601 ligand binding site [chemical binding]; other site 710686007602 catalytic site [active] 710686007603 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 710686007604 intersubunit interface [polypeptide binding]; other site 710686007605 active site 710686007606 Zn2+ binding site [ion binding]; other site 710686007607 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 710686007608 SelR domain; Region: SelR; pfam01641 710686007609 Double zinc ribbon; Region: DZR; pfam12773 710686007610 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686007611 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686007612 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686007613 cyclase homology domain; Region: CHD; cd07302 710686007614 nucleotidyl binding site; other site 710686007615 metal binding site [ion binding]; metal-binding site 710686007616 dimer interface [polypeptide binding]; other site 710686007617 AAA ATPase domain; Region: AAA_16; pfam13191 710686007618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686007619 Ecdysteroid kinase; Region: EcKinase; cl17738 710686007620 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710686007621 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007622 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686007623 hypothetical protein; Provisional; Region: PRK14059 710686007624 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710686007625 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 710686007626 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 710686007627 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686007628 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686007629 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 710686007630 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710686007631 DNA binding site [nucleotide binding] 710686007632 active site 710686007633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710686007634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686007635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686007636 DNA binding residues [nucleotide binding] 710686007637 Clp amino terminal domain; Region: Clp_N; pfam02861 710686007638 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686007639 hydrophobic ligand binding site; other site 710686007640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686007641 Helix-turn-helix domain; Region: HTH_18; pfam12833 710686007642 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 710686007643 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710686007644 active site 710686007645 DNA binding site [nucleotide binding] 710686007646 Int/Topo IB signature motif; other site 710686007647 Phage capsid family; Region: Phage_capsid; pfam05065 710686007648 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710686007649 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710686007650 Septum formation initiator; Region: DivIC; cl17659 710686007651 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 710686007652 T5orf172 domain; Region: T5orf172; pfam10544 710686007653 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686007654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686007655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686007656 DNA binding residues [nucleotide binding] 710686007657 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686007658 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 710686007659 putative heme binding pocket [chemical binding]; other site 710686007660 choline dehydrogenase; Validated; Region: PRK02106 710686007661 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686007662 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710686007663 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710686007664 catalytic triad [active] 710686007665 Protein of unknown function (DUF742); Region: DUF742; pfam05331 710686007666 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710686007667 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710686007668 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686007669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686007670 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686007671 GAF domain; Region: GAF_2; pfam13185 710686007672 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686007673 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 710686007674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686007675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686007676 active site 710686007677 catalytic tetrad [active] 710686007678 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686007679 CoenzymeA binding site [chemical binding]; other site 710686007680 subunit interaction site [polypeptide binding]; other site 710686007681 PHB binding site; other site 710686007682 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 710686007683 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710686007684 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 710686007685 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710686007686 active site 710686007687 dimer interface [polypeptide binding]; other site 710686007688 motif 1; other site 710686007689 motif 2; other site 710686007690 motif 3; other site 710686007691 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710686007692 anticodon binding site; other site 710686007693 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 710686007694 nucleotide binding site/active site [active] 710686007695 HIT family signature motif; other site 710686007696 catalytic residue [active] 710686007697 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710686007698 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 710686007699 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 710686007700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 710686007701 putative acyl-acceptor binding pocket; other site 710686007702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686007703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686007704 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 710686007705 nudix motif; other site 710686007706 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 710686007707 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 710686007708 active site 710686007709 multimer interface [polypeptide binding]; other site 710686007710 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710686007711 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710686007712 active site 710686007713 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710686007714 catalytic triad [active] 710686007715 dimer interface [polypeptide binding]; other site 710686007716 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 710686007717 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 710686007718 predicted active site [active] 710686007719 catalytic triad [active] 710686007720 short chain dehydrogenase; Validated; Region: PRK08264 710686007721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686007722 NAD(P) binding site [chemical binding]; other site 710686007723 active site 710686007724 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686007725 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686007726 hypothetical protein; Validated; Region: PRK00110 710686007727 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 710686007728 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 710686007729 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686007730 molybdopterin cofactor binding site; other site 710686007731 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 710686007732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686007733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686007734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686007735 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 710686007736 active site 710686007737 putative DNA-binding cleft [nucleotide binding]; other site 710686007738 dimer interface [polypeptide binding]; other site 710686007739 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710686007740 RuvA N terminal domain; Region: RuvA_N; pfam01330 710686007741 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 710686007742 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710686007743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686007744 Walker A motif; other site 710686007745 ATP binding site [chemical binding]; other site 710686007746 Walker B motif; other site 710686007747 arginine finger; other site 710686007748 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710686007749 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 710686007750 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710686007751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686007752 acyl-activating enzyme (AAE) consensus motif; other site 710686007753 AMP binding site [chemical binding]; other site 710686007754 active site 710686007755 CoA binding site [chemical binding]; other site 710686007756 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686007757 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710686007758 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 710686007759 putative NAD(P) binding site [chemical binding]; other site 710686007760 active site 710686007761 putative substrate binding site [chemical binding]; other site 710686007762 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710686007763 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 710686007764 tetrameric interface [polypeptide binding]; other site 710686007765 NAD binding site [chemical binding]; other site 710686007766 catalytic residues [active] 710686007767 substrate binding site [chemical binding]; other site 710686007768 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 710686007769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686007770 inhibitor-cofactor binding pocket; inhibition site 710686007771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686007772 catalytic residue [active] 710686007773 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686007774 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686007775 active site 710686007776 metal binding site [ion binding]; metal-binding site 710686007777 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 710686007778 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 710686007779 Protein export membrane protein; Region: SecD_SecF; cl14618 710686007780 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 710686007781 Protein export membrane protein; Region: SecD_SecF; pfam02355 710686007782 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710686007783 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710686007784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686007785 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 710686007786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686007787 Zn2+ binding site [ion binding]; other site 710686007788 Mg2+ binding site [ion binding]; other site 710686007789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710686007790 synthetase active site [active] 710686007791 NTP binding site [chemical binding]; other site 710686007792 metal binding site [ion binding]; metal-binding site 710686007793 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 710686007794 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 710686007795 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710686007796 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710686007797 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710686007798 active site 710686007799 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710686007800 active site 710686007801 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710686007802 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 710686007803 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 710686007804 dimer interface [polypeptide binding]; other site 710686007805 motif 1; other site 710686007806 active site 710686007807 motif 2; other site 710686007808 motif 3; other site 710686007809 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 710686007810 anticodon binding site; other site 710686007811 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 710686007812 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686007813 haloalkane dehalogenase; Provisional; Region: PRK03592 710686007814 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 710686007815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686007816 hypothetical protein; Provisional; Region: PRK07236 710686007817 hypothetical protein; Provisional; Region: PRK06847 710686007818 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686007819 Transcriptional regulator PadR-like family; Region: PadR; cl17335 710686007820 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 710686007821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686007822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686007823 active site 710686007824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686007825 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686007826 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686007827 active site 710686007828 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686007829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686007830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686007831 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710686007832 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710686007833 active site 710686007834 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710686007835 catalytic triad [active] 710686007836 dimer interface [polypeptide binding]; other site 710686007837 DinB superfamily; Region: DinB_2; pfam12867 710686007838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 710686007840 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710686007841 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710686007842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686007843 substrate binding pocket [chemical binding]; other site 710686007844 catalytic triad [active] 710686007845 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686007846 putative hydrophobic ligand binding site [chemical binding]; other site 710686007847 protein interface [polypeptide binding]; other site 710686007848 gate; other site 710686007849 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 710686007850 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710686007851 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710686007852 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710686007853 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 710686007854 dimer interface [polypeptide binding]; other site 710686007855 anticodon binding site; other site 710686007856 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 710686007857 homodimer interface [polypeptide binding]; other site 710686007858 motif 1; other site 710686007859 active site 710686007860 motif 2; other site 710686007861 GAD domain; Region: GAD; pfam02938 710686007862 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710686007863 active site 710686007864 motif 3; other site 710686007865 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686007866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686007867 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686007868 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686007869 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686007870 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686007871 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686007872 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686007873 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710686007874 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686007875 dimer interface [polypeptide binding]; other site 710686007876 active site 710686007877 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686007878 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686007879 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 710686007880 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710686007881 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710686007882 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710686007883 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 710686007884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 710686007885 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 710686007886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710686007887 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710686007888 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710686007889 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710686007890 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710686007891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 710686007892 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 710686007893 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 710686007894 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 710686007895 Cupin domain; Region: Cupin_2; cl17218 710686007896 recombination factor protein RarA; Reviewed; Region: PRK13342 710686007897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686007898 Walker A motif; other site 710686007899 ATP binding site [chemical binding]; other site 710686007900 Walker B motif; other site 710686007901 arginine finger; other site 710686007902 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 710686007903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686007904 dimerization interface [polypeptide binding]; other site 710686007905 putative DNA binding site [nucleotide binding]; other site 710686007906 putative Zn2+ binding site [ion binding]; other site 710686007907 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 710686007908 putative hydrophobic ligand binding site [chemical binding]; other site 710686007909 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710686007910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686007911 Predicted membrane protein [Function unknown]; Region: COG2261 710686007912 Uncharacterized conserved protein [Function unknown]; Region: COG0432 710686007913 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710686007914 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 710686007915 motif 1; other site 710686007916 active site 710686007917 motif 2; other site 710686007918 motif 3; other site 710686007919 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710686007920 DHHA1 domain; Region: DHHA1; pfam02272 710686007921 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 710686007922 YceG-like family; Region: YceG; pfam02618 710686007923 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 710686007924 dimerization interface [polypeptide binding]; other site 710686007925 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 710686007926 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710686007927 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710686007928 shikimate binding site; other site 710686007929 NAD(P) binding site [chemical binding]; other site 710686007930 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 710686007931 EamA-like transporter family; Region: EamA; pfam00892 710686007932 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 710686007933 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686007934 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 710686007935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686007936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686007937 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 710686007938 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 710686007939 Tetramer interface [polypeptide binding]; other site 710686007940 active site 710686007941 FMN-binding site [chemical binding]; other site 710686007942 shikimate kinase; Reviewed; Region: aroK; PRK00131 710686007943 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 710686007944 ADP binding site [chemical binding]; other site 710686007945 magnesium binding site [ion binding]; other site 710686007946 putative shikimate binding site; other site 710686007947 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 710686007948 active site 710686007949 dimer interface [polypeptide binding]; other site 710686007950 metal binding site [ion binding]; metal-binding site 710686007951 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 710686007952 Dehydroquinase class II; Region: DHquinase_II; pfam01220 710686007953 trimer interface [polypeptide binding]; other site 710686007954 active site 710686007955 dimer interface [polypeptide binding]; other site 710686007956 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686007957 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686007958 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710686007959 active site 710686007960 elongation factor P; Validated; Region: PRK00529 710686007961 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710686007962 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 710686007963 RNA binding site [nucleotide binding]; other site 710686007964 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 710686007965 RNA binding site [nucleotide binding]; other site 710686007966 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 710686007967 putative RNA binding site [nucleotide binding]; other site 710686007968 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710686007969 putative active site [active] 710686007970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686007971 DNA-binding site [nucleotide binding]; DNA binding site 710686007972 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686007973 UTRA domain; Region: UTRA; pfam07702 710686007974 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 710686007975 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710686007976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 710686007977 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710686007978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710686007979 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710686007980 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710686007981 Walker A/P-loop; other site 710686007982 ATP binding site [chemical binding]; other site 710686007983 Q-loop/lid; other site 710686007984 ABC transporter signature motif; other site 710686007985 Walker B; other site 710686007986 D-loop; other site 710686007987 H-loop/switch region; other site 710686007988 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 710686007989 L-aspartate oxidase; Provisional; Region: PRK06175 710686007990 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710686007991 hypothetical protein; Validated; Region: PRK05868 710686007992 hypothetical protein; Provisional; Region: PRK07236 710686007993 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686007994 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686007995 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 710686007996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686007997 active site 710686007998 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 710686007999 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710686008000 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710686008001 dihydroorotase; Validated; Region: pyrC; PRK09357 710686008002 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686008003 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 710686008004 active site 710686008005 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 710686008006 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 710686008007 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 710686008008 catalytic site [active] 710686008009 subunit interface [polypeptide binding]; other site 710686008010 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 710686008011 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686008012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686008013 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 710686008014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686008015 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686008016 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 710686008017 IMP binding site; other site 710686008018 dimer interface [polypeptide binding]; other site 710686008019 interdomain contacts; other site 710686008020 partial ornithine binding site; other site 710686008021 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 710686008022 active site 710686008023 dimer interface [polypeptide binding]; other site 710686008024 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 710686008025 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 710686008026 catalytic site [active] 710686008027 G-X2-G-X-G-K; other site 710686008028 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 710686008029 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 710686008030 Flavoprotein; Region: Flavoprotein; pfam02441 710686008031 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 710686008032 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710686008033 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710686008034 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710686008035 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710686008036 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686008037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686008038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686008039 Zn2+ binding site [ion binding]; other site 710686008040 Mg2+ binding site [ion binding]; other site 710686008041 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710686008042 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686008043 conserved cys residue [active] 710686008044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686008045 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686008046 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686008047 Predicted membrane protein [Function unknown]; Region: COG3714 710686008048 primosome assembly protein PriA; Provisional; Region: PRK14873 710686008049 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 710686008050 LemA family; Region: LemA; cl00742 710686008051 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710686008052 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710686008053 putative active site [active] 710686008054 substrate binding site [chemical binding]; other site 710686008055 putative cosubstrate binding site; other site 710686008056 catalytic site [active] 710686008057 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710686008058 substrate binding site [chemical binding]; other site 710686008059 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 710686008060 16S rRNA methyltransferase B; Provisional; Region: PRK14902 710686008061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686008062 S-adenosylmethionine binding site [chemical binding]; other site 710686008063 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 710686008064 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 710686008065 substrate binding site [chemical binding]; other site 710686008066 hexamer interface [polypeptide binding]; other site 710686008067 metal binding site [ion binding]; metal-binding site 710686008068 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 710686008069 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 710686008070 catalytic motif [active] 710686008071 Zn binding site [ion binding]; other site 710686008072 RibD C-terminal domain; Region: RibD_C; pfam01872 710686008073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686008074 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686008075 Walker A/P-loop; other site 710686008076 ATP binding site [chemical binding]; other site 710686008077 Q-loop/lid; other site 710686008078 ABC transporter signature motif; other site 710686008079 Walker B; other site 710686008080 D-loop; other site 710686008081 H-loop/switch region; other site 710686008082 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686008083 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686008084 ligand binding site [chemical binding]; other site 710686008085 flexible hinge region; other site 710686008086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710686008087 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 710686008088 intracellular protease, PfpI family; Region: PfpI; TIGR01382 710686008089 proposed catalytic triad [active] 710686008090 conserved cys residue [active] 710686008091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686008092 putative substrate translocation pore; other site 710686008093 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 710686008094 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 710686008095 Lumazine binding domain; Region: Lum_binding; pfam00677 710686008096 Lumazine binding domain; Region: Lum_binding; pfam00677 710686008097 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 710686008098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710686008099 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710686008100 dimerization interface [polypeptide binding]; other site 710686008101 active site 710686008102 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 710686008103 homopentamer interface [polypeptide binding]; other site 710686008104 active site 710686008105 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710686008106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710686008107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686008108 Coenzyme A binding pocket [chemical binding]; other site 710686008109 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 710686008110 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 710686008111 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710686008112 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710686008113 GIY-YIG motif/motif A; other site 710686008114 active site 710686008115 catalytic site [active] 710686008116 putative DNA binding site [nucleotide binding]; other site 710686008117 metal binding site [ion binding]; metal-binding site 710686008118 UvrB/uvrC motif; Region: UVR; pfam02151 710686008119 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710686008120 minor groove reading motif; other site 710686008121 Helix-hairpin-helix motif; Region: HHH; pfam00633 710686008122 helix-hairpin-helix signature motif; other site 710686008123 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 710686008124 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 710686008125 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 710686008126 phosphate binding site [ion binding]; other site 710686008127 putative substrate binding pocket [chemical binding]; other site 710686008128 dimer interface [polypeptide binding]; other site 710686008129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710686008130 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 710686008131 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686008132 cyclase homology domain; Region: CHD; cd07302 710686008133 nucleotidyl binding site; other site 710686008134 metal binding site [ion binding]; metal-binding site 710686008135 dimer interface [polypeptide binding]; other site 710686008136 Predicted ATPase [General function prediction only]; Region: COG3903 710686008137 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686008138 cyclase homology domain; Region: CHD; cd07302 710686008139 nucleotidyl binding site; other site 710686008140 metal binding site [ion binding]; metal-binding site 710686008141 dimer interface [polypeptide binding]; other site 710686008142 Predicted ATPase [General function prediction only]; Region: COG3903 710686008143 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686008144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686008145 substrate binding pocket [chemical binding]; other site 710686008146 membrane-bound complex binding site; other site 710686008147 hinge residues; other site 710686008148 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 710686008149 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 710686008150 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710686008151 Phosphoglycerate kinase; Region: PGK; pfam00162 710686008152 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 710686008153 substrate binding site [chemical binding]; other site 710686008154 hinge regions; other site 710686008155 ADP binding site [chemical binding]; other site 710686008156 catalytic site [active] 710686008157 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710686008158 triosephosphate isomerase; Provisional; Region: PRK14565 710686008159 substrate binding site [chemical binding]; other site 710686008160 dimer interface [polypeptide binding]; other site 710686008161 catalytic triad [active] 710686008162 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 710686008163 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 710686008164 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710686008165 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 710686008166 putative active site [active] 710686008167 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 710686008168 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 710686008169 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 710686008170 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710686008171 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710686008172 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710686008173 putative active site [active] 710686008174 transaldolase; Provisional; Region: PRK03903 710686008175 catalytic residue [active] 710686008176 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 710686008177 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710686008178 TPP-binding site [chemical binding]; other site 710686008179 dimer interface [polypeptide binding]; other site 710686008180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710686008181 PYR/PP interface [polypeptide binding]; other site 710686008182 dimer interface [polypeptide binding]; other site 710686008183 TPP binding site [chemical binding]; other site 710686008184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686008185 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 710686008186 UbiA prenyltransferase family; Region: UbiA; pfam01040 710686008187 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 710686008188 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 710686008189 NADP binding site [chemical binding]; other site 710686008190 dimer interface [polypeptide binding]; other site 710686008191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686008192 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 710686008193 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 710686008194 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686008195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710686008196 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710686008197 Walker A/P-loop; other site 710686008198 ATP binding site [chemical binding]; other site 710686008199 Q-loop/lid; other site 710686008200 ABC transporter signature motif; other site 710686008201 Walker B; other site 710686008202 D-loop; other site 710686008203 H-loop/switch region; other site 710686008204 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710686008205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 710686008206 Predicted transcriptional regulator [Transcription]; Region: COG2345 710686008207 putative DNA binding site [nucleotide binding]; other site 710686008208 putative Zn2+ binding site [ion binding]; other site 710686008209 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710686008210 FeS assembly protein SufB; Region: sufB; TIGR01980 710686008211 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 710686008212 FeS assembly protein SufD; Region: sufD; TIGR01981 710686008213 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 710686008214 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 710686008215 Walker A/P-loop; other site 710686008216 ATP binding site [chemical binding]; other site 710686008217 Q-loop/lid; other site 710686008218 ABC transporter signature motif; other site 710686008219 Walker B; other site 710686008220 D-loop; other site 710686008221 H-loop/switch region; other site 710686008222 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710686008223 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 710686008224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686008225 catalytic residue [active] 710686008226 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 710686008227 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710686008228 trimerization site [polypeptide binding]; other site 710686008229 active site 710686008230 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710686008231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686008232 MarR family; Region: MarR_2; pfam12802 710686008233 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686008234 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 710686008235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686008236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686008237 DNA binding residues [nucleotide binding] 710686008238 Putative zinc-finger; Region: zf-HC2; pfam13490 710686008239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686008240 catalytic residues [active] 710686008241 enoyl-CoA hydratase; Provisional; Region: PRK05864 710686008242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686008243 substrate binding site [chemical binding]; other site 710686008244 oxyanion hole (OAH) forming residues; other site 710686008245 trimer interface [polypeptide binding]; other site 710686008246 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 710686008247 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710686008248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686008249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686008250 ABC transporter; Region: ABC_tran_2; pfam12848 710686008251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686008252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008254 aconitate hydratase; Validated; Region: PRK09277 710686008255 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710686008256 substrate binding site [chemical binding]; other site 710686008257 ligand binding site [chemical binding]; other site 710686008258 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 710686008259 substrate binding site [chemical binding]; other site 710686008260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 710686008261 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686008262 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686008263 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686008264 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686008265 MoxR-like ATPases [General function prediction only]; Region: COG0714 710686008266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686008267 Walker A motif; other site 710686008268 ATP binding site [chemical binding]; other site 710686008269 Walker B motif; other site 710686008270 arginine finger; other site 710686008271 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710686008272 Protein of unknown function DUF58; Region: DUF58; pfam01882 710686008273 hypothetical protein; Provisional; Region: PRK13685 710686008274 Aerotolerance regulator N-terminal; Region: BatA; cl06567 710686008275 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710686008276 metal ion-dependent adhesion site (MIDAS); other site 710686008277 hypothetical protein; Provisional; Region: PRK13685 710686008278 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 710686008279 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710686008280 metal ion-dependent adhesion site (MIDAS); other site 710686008281 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 710686008282 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710686008283 NAD(P) binding site [chemical binding]; other site 710686008284 homotetramer interface [polypeptide binding]; other site 710686008285 homodimer interface [polypeptide binding]; other site 710686008286 active site 710686008287 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 710686008288 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 710686008289 NAD binding site [chemical binding]; other site 710686008290 homotetramer interface [polypeptide binding]; other site 710686008291 homodimer interface [polypeptide binding]; other site 710686008292 substrate binding site [chemical binding]; other site 710686008293 active site 710686008294 ferrochelatase; Reviewed; Region: hemH; PRK00035 710686008295 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 710686008296 C-terminal domain interface [polypeptide binding]; other site 710686008297 active site 710686008298 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 710686008299 active site 710686008300 N-terminal domain interface [polypeptide binding]; other site 710686008301 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 710686008302 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710686008303 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710686008304 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710686008305 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710686008306 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 710686008307 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 710686008308 heterodimer interface [polypeptide binding]; other site 710686008309 substrate interaction site [chemical binding]; other site 710686008310 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710686008311 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 710686008312 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 710686008313 active site 710686008314 substrate binding site [chemical binding]; other site 710686008315 coenzyme B12 binding site [chemical binding]; other site 710686008316 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710686008317 B12 binding site [chemical binding]; other site 710686008318 cobalt ligand [ion binding]; other site 710686008319 membrane ATPase/protein kinase; Provisional; Region: PRK09435 710686008320 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 710686008321 Walker A; other site 710686008322 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686008323 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686008324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710686008325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710686008326 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710686008327 Dodecin; Region: Dodecin; pfam07311 710686008328 PHP-associated; Region: PHP_C; pfam13263 710686008329 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686008330 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686008331 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 710686008332 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710686008333 HIGH motif; other site 710686008334 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710686008335 active site 710686008336 KMSKS motif; other site 710686008337 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 710686008338 tRNA binding surface [nucleotide binding]; other site 710686008339 anticodon binding site; other site 710686008340 Cupin domain; Region: Cupin_2; cl17218 710686008341 DNA polymerase IV; Provisional; Region: PRK03348 710686008342 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710686008343 active site 710686008344 DNA binding site [nucleotide binding] 710686008345 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 710686008346 active site 710686008347 homotetramer interface [polypeptide binding]; other site 710686008348 homodimer interface [polypeptide binding]; other site 710686008349 lipoprotein signal peptidase; Provisional; Region: PRK14764 710686008350 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710686008351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710686008352 RNA binding surface [nucleotide binding]; other site 710686008353 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710686008354 active site 710686008355 Predicted permeases [General function prediction only]; Region: RarD; COG2962 710686008356 YCII-related domain; Region: YCII; cl00999 710686008357 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710686008358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008360 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 710686008361 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 710686008362 active site 710686008363 PHP Thumb interface [polypeptide binding]; other site 710686008364 metal binding site [ion binding]; metal-binding site 710686008365 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710686008366 generic binding surface II; other site 710686008367 generic binding surface I; other site 710686008368 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 710686008369 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686008370 threonine dehydratase; Validated; Region: PRK08639 710686008371 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710686008372 tetramer interface [polypeptide binding]; other site 710686008373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686008374 catalytic residue [active] 710686008375 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 710686008376 putative Ile/Val binding site [chemical binding]; other site 710686008377 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 710686008378 putative active site [active] 710686008379 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710686008380 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 710686008381 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 710686008382 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 710686008383 catalytic site [active] 710686008384 active site 710686008385 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710686008386 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 710686008387 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 710686008388 active site 710686008389 catalytic site [active] 710686008390 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710686008391 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710686008392 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710686008393 active site 710686008394 catalytic site [active] 710686008395 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710686008396 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 710686008397 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686008398 inhibitor-cofactor binding pocket; inhibition site 710686008399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686008400 catalytic residue [active] 710686008401 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 710686008402 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 710686008403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686008404 catalytic residue [active] 710686008405 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710686008406 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710686008407 Protein of unknown function (DUF419); Region: DUF419; cl15265 710686008408 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710686008409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008410 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686008411 biotin synthase; Validated; Region: PRK06256 710686008412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686008413 FeS/SAM binding site; other site 710686008414 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 710686008415 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 710686008416 Secretory lipase; Region: LIP; pfam03583 710686008417 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 710686008418 nudix motif; other site 710686008419 nudix motif; other site 710686008420 quinolinate synthetase; Provisional; Region: PRK09375 710686008421 L-aspartate oxidase; Provisional; Region: PRK07804 710686008422 L-aspartate oxidase; Provisional; Region: PRK06175 710686008423 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710686008424 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 710686008425 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 710686008426 dimerization interface [polypeptide binding]; other site 710686008427 active site 710686008428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008430 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686008431 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686008432 NAD(P) binding site [chemical binding]; other site 710686008433 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686008434 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686008435 LysE type translocator; Region: LysE; cl00565 710686008436 Domain of unknown function (DUF385); Region: DUF385; cl04387 710686008437 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 710686008438 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 710686008439 NAD binding site [chemical binding]; other site 710686008440 dimerization interface [polypeptide binding]; other site 710686008441 product binding site; other site 710686008442 substrate binding site [chemical binding]; other site 710686008443 zinc binding site [ion binding]; other site 710686008444 catalytic residues [active] 710686008445 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 710686008446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686008448 homodimer interface [polypeptide binding]; other site 710686008449 catalytic residue [active] 710686008450 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 710686008451 putative active site pocket [active] 710686008452 4-fold oligomerization interface [polypeptide binding]; other site 710686008453 metal binding residues [ion binding]; metal-binding site 710686008454 3-fold/trimer interface [polypeptide binding]; other site 710686008455 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 710686008456 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 710686008457 putative active site [active] 710686008458 oxyanion strand; other site 710686008459 catalytic triad [active] 710686008460 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 710686008461 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710686008462 catalytic residues [active] 710686008463 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 710686008464 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710686008465 active site 710686008466 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 710686008467 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710686008468 substrate binding site [chemical binding]; other site 710686008469 glutamase interaction surface [polypeptide binding]; other site 710686008470 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 710686008471 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686008472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686008473 NAD(P) binding site [chemical binding]; other site 710686008474 active site 710686008475 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 710686008476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686008477 Walker A/P-loop; other site 710686008478 ATP binding site [chemical binding]; other site 710686008479 Q-loop/lid; other site 710686008480 ABC transporter signature motif; other site 710686008481 Walker B; other site 710686008482 D-loop; other site 710686008483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686008484 PAS domain; Region: PAS_9; pfam13426 710686008485 putative active site [active] 710686008486 heme pocket [chemical binding]; other site 710686008487 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710686008488 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710686008489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686008490 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710686008491 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710686008492 catalytic triad [active] 710686008493 anthranilate synthase component I; Provisional; Region: PRK13571 710686008494 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 710686008495 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710686008496 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 710686008497 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 710686008498 active site 710686008499 ribulose/triose binding site [chemical binding]; other site 710686008500 phosphate binding site [ion binding]; other site 710686008501 substrate (anthranilate) binding pocket [chemical binding]; other site 710686008502 product (indole) binding pocket [chemical binding]; other site 710686008503 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 710686008504 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 710686008505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686008506 catalytic residue [active] 710686008507 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 710686008508 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 710686008509 substrate binding site [chemical binding]; other site 710686008510 active site 710686008511 catalytic residues [active] 710686008512 heterodimer interface [polypeptide binding]; other site 710686008513 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 710686008514 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686008515 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686008516 active site 710686008517 TM2 domain; Region: TM2; pfam05154 710686008518 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710686008519 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710686008520 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710686008521 active site 710686008522 dimer interface [polypeptide binding]; other site 710686008523 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710686008524 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710686008525 active site 710686008526 FMN binding site [chemical binding]; other site 710686008527 substrate binding site [chemical binding]; other site 710686008528 3Fe-4S cluster binding site [ion binding]; other site 710686008529 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710686008530 domain interface; other site 710686008531 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710686008532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686008533 pyruvate kinase; Provisional; Region: PRK06247 710686008534 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710686008535 domain interfaces; other site 710686008536 active site 710686008537 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710686008538 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710686008539 active site 710686008540 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710686008541 catalytic triad [active] 710686008542 dimer interface [polypeptide binding]; other site 710686008543 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 710686008544 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710686008545 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 710686008546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686008547 Walker A/P-loop; other site 710686008548 ATP binding site [chemical binding]; other site 710686008549 Q-loop/lid; other site 710686008550 ABC transporter signature motif; other site 710686008551 Walker B; other site 710686008552 D-loop; other site 710686008553 H-loop/switch region; other site 710686008554 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 710686008555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686008556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686008557 Walker A/P-loop; other site 710686008558 ATP binding site [chemical binding]; other site 710686008559 Q-loop/lid; other site 710686008560 ABC transporter signature motif; other site 710686008561 Walker B; other site 710686008562 D-loop; other site 710686008563 H-loop/switch region; other site 710686008564 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710686008565 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710686008566 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 710686008567 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 710686008568 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 710686008569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686008570 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686008571 substrate binding pocket [chemical binding]; other site 710686008572 membrane-bound complex binding site; other site 710686008573 hinge residues; other site 710686008574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710686008575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686008576 dimer interface [polypeptide binding]; other site 710686008577 conserved gate region; other site 710686008578 ABC-ATPase subunit interface; other site 710686008579 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710686008580 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710686008581 Walker A/P-loop; other site 710686008582 ATP binding site [chemical binding]; other site 710686008583 Q-loop/lid; other site 710686008584 ABC transporter signature motif; other site 710686008585 Walker B; other site 710686008586 D-loop; other site 710686008587 H-loop/switch region; other site 710686008588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686008589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710686008590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686008591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686008592 active site 710686008593 phosphorylation site [posttranslational modification] 710686008594 intermolecular recognition site; other site 710686008595 dimerization interface [polypeptide binding]; other site 710686008596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686008597 DNA binding residues [nucleotide binding] 710686008598 dimerization interface [polypeptide binding]; other site 710686008599 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710686008600 Ferritin-like domain; Region: Ferritin; pfam00210 710686008601 dimerization interface [polypeptide binding]; other site 710686008602 DPS ferroxidase diiron center [ion binding]; other site 710686008603 ion pore; other site 710686008604 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686008605 cyclase homology domain; Region: CHD; cd07302 710686008606 nucleotidyl binding site; other site 710686008607 metal binding site [ion binding]; metal-binding site 710686008608 dimer interface [polypeptide binding]; other site 710686008609 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 710686008610 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686008611 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 710686008612 agmatinase; Region: agmatinase; TIGR01230 710686008613 oligomer interface [polypeptide binding]; other site 710686008614 putative active site [active] 710686008615 Mn binding site [ion binding]; other site 710686008616 hypothetical protein; Provisional; Region: PRK07524 710686008617 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686008618 PYR/PP interface [polypeptide binding]; other site 710686008619 dimer interface [polypeptide binding]; other site 710686008620 TPP binding site [chemical binding]; other site 710686008621 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686008622 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 710686008623 TPP-binding site [chemical binding]; other site 710686008624 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 710686008625 Na binding site [ion binding]; other site 710686008626 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 710686008627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686008628 active site 710686008629 phosphorylation site [posttranslational modification] 710686008630 intermolecular recognition site; other site 710686008631 dimerization interface [polypeptide binding]; other site 710686008632 ANTAR domain; Region: ANTAR; pfam03861 710686008633 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710686008634 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 710686008635 dimerization interface [polypeptide binding]; other site 710686008636 ligand binding site [chemical binding]; other site 710686008637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710686008638 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710686008639 TM-ABC transporter signature motif; other site 710686008640 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710686008641 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710686008642 TM-ABC transporter signature motif; other site 710686008643 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710686008644 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710686008645 Walker A/P-loop; other site 710686008646 ATP binding site [chemical binding]; other site 710686008647 Q-loop/lid; other site 710686008648 ABC transporter signature motif; other site 710686008649 Walker B; other site 710686008650 D-loop; other site 710686008651 H-loop/switch region; other site 710686008652 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710686008653 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710686008654 Walker A/P-loop; other site 710686008655 ATP binding site [chemical binding]; other site 710686008656 Q-loop/lid; other site 710686008657 ABC transporter signature motif; other site 710686008658 Walker B; other site 710686008659 D-loop; other site 710686008660 H-loop/switch region; other site 710686008661 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 710686008662 lipid-transfer protein; Provisional; Region: PRK06059 710686008663 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686008664 active site 710686008665 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686008666 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686008667 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686008668 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686008669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686008670 FAD binding domain; Region: FAD_binding_3; pfam01494 710686008671 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686008672 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 710686008673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686008674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 710686008675 putative dimerization interface [polypeptide binding]; other site 710686008676 DNA polymerase I; Provisional; Region: PRK05755 710686008677 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710686008678 active site 710686008679 metal binding site 1 [ion binding]; metal-binding site 710686008680 putative 5' ssDNA interaction site; other site 710686008681 metal binding site 3; metal-binding site 710686008682 metal binding site 2 [ion binding]; metal-binding site 710686008683 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710686008684 putative DNA binding site [nucleotide binding]; other site 710686008685 putative metal binding site [ion binding]; other site 710686008686 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 710686008687 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 710686008688 active site 710686008689 DNA binding site [nucleotide binding] 710686008690 catalytic site [active] 710686008691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686008692 Src homology 2 (SH2) domain; Region: SH2; cl15255 710686008693 phosphotyrosine binding pocket [polypeptide binding]; other site 710686008694 hydrophobic binding pocket [polypeptide binding]; other site 710686008695 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686008696 cyclase homology domain; Region: CHD; cd07302 710686008697 nucleotidyl binding site; other site 710686008698 metal binding site [ion binding]; metal-binding site 710686008699 dimer interface [polypeptide binding]; other site 710686008700 Protease prsW family; Region: PrsW-protease; pfam13367 710686008701 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 710686008702 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 710686008703 RNA binding site [nucleotide binding]; other site 710686008704 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 710686008705 RNA binding site [nucleotide binding]; other site 710686008706 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710686008707 RNA binding site [nucleotide binding]; other site 710686008708 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 710686008709 RNA binding site [nucleotide binding]; other site 710686008710 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 710686008711 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710686008712 CoA-binding site [chemical binding]; other site 710686008713 ATP-binding [chemical binding]; other site 710686008714 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 710686008715 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710686008716 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710686008717 DNA binding site [nucleotide binding] 710686008718 catalytic residue [active] 710686008719 H2TH interface [polypeptide binding]; other site 710686008720 putative catalytic residues [active] 710686008721 turnover-facilitating residue; other site 710686008722 intercalation triad [nucleotide binding]; other site 710686008723 8OG recognition residue [nucleotide binding]; other site 710686008724 putative reading head residues; other site 710686008725 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710686008726 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710686008727 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 710686008728 nucleotide binding site [chemical binding]; other site 710686008729 Protein of unknown function (DUF402); Region: DUF402; cl00979 710686008730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008732 enoyl-CoA hydratase; Provisional; Region: PRK06563 710686008733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686008734 substrate binding site [chemical binding]; other site 710686008735 oxyanion hole (OAH) forming residues; other site 710686008736 trimer interface [polypeptide binding]; other site 710686008737 excinuclease ABC subunit B; Provisional; Region: PRK05298 710686008738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686008739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686008740 nucleotide binding region [chemical binding]; other site 710686008741 ATP-binding site [chemical binding]; other site 710686008742 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710686008743 UvrB/uvrC motif; Region: UVR; pfam02151 710686008744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686008745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686008746 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 710686008747 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 710686008748 MgtC family; Region: MgtC; pfam02308 710686008749 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710686008750 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686008751 hydrophobic ligand binding site; other site 710686008752 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686008753 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 710686008754 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710686008755 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 710686008756 active site 710686008757 catalytic triad [active] 710686008758 dimer interface [polypeptide binding]; other site 710686008759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686008760 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686008761 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 710686008762 Fe-S cluster binding site [ion binding]; other site 710686008763 active site 710686008764 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710686008765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686008766 Ligand Binding Site [chemical binding]; other site 710686008767 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 710686008768 catalytic residue [active] 710686008769 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686008770 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710686008771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710686008772 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710686008773 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710686008774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710686008775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686008776 Coenzyme A binding pocket [chemical binding]; other site 710686008777 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710686008778 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710686008779 CHAT domain; Region: CHAT; cl17868 710686008780 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710686008781 S-formylglutathione hydrolase; Region: PLN02442 710686008782 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 710686008783 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 710686008784 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710686008785 dimer interface [polypeptide binding]; other site 710686008786 putative anticodon binding site; other site 710686008787 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710686008788 motif 1; other site 710686008789 dimer interface [polypeptide binding]; other site 710686008790 active site 710686008791 motif 2; other site 710686008792 motif 3; other site 710686008793 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 710686008794 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710686008795 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710686008796 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 710686008797 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710686008798 23S rRNA binding site [nucleotide binding]; other site 710686008799 L21 binding site [polypeptide binding]; other site 710686008800 L13 binding site [polypeptide binding]; other site 710686008801 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710686008802 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 710686008803 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710686008804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686008805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686008806 active site 710686008807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 710686008808 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686008809 cyclase homology domain; Region: CHD; cd07302 710686008810 nucleotidyl binding site; other site 710686008811 metal binding site [ion binding]; metal-binding site 710686008812 dimer interface [polypeptide binding]; other site 710686008813 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710686008814 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710686008815 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710686008816 dimer interface [polypeptide binding]; other site 710686008817 motif 1; other site 710686008818 active site 710686008819 motif 2; other site 710686008820 motif 3; other site 710686008821 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710686008822 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710686008823 putative tRNA-binding site [nucleotide binding]; other site 710686008824 B3/4 domain; Region: B3_4; pfam03483 710686008825 tRNA synthetase B5 domain; Region: B5; smart00874 710686008826 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710686008827 dimer interface [polypeptide binding]; other site 710686008828 motif 1; other site 710686008829 motif 3; other site 710686008830 motif 2; other site 710686008831 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 710686008832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686008833 Cytochrome P450; Region: p450; cl12078 710686008834 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 710686008835 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 710686008836 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 710686008837 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710686008838 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 710686008839 heterotetramer interface [polypeptide binding]; other site 710686008840 active site pocket [active] 710686008841 cleavage site 710686008842 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 710686008843 feedback inhibition sensing region; other site 710686008844 homohexameric interface [polypeptide binding]; other site 710686008845 nucleotide binding site [chemical binding]; other site 710686008846 N-acetyl-L-glutamate binding site [chemical binding]; other site 710686008847 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 710686008848 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686008849 inhibitor-cofactor binding pocket; inhibition site 710686008850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686008851 catalytic residue [active] 710686008852 ornithine carbamoyltransferase; Provisional; Region: PRK00779 710686008853 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710686008854 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710686008855 arginine repressor; Provisional; Region: PRK03341 710686008856 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 710686008857 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 710686008858 argininosuccinate synthase; Provisional; Region: PRK13820 710686008859 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 710686008860 ANP binding site [chemical binding]; other site 710686008861 Substrate Binding Site II [chemical binding]; other site 710686008862 Substrate Binding Site I [chemical binding]; other site 710686008863 argininosuccinate lyase; Provisional; Region: PRK00855 710686008864 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 710686008865 active sites [active] 710686008866 tetramer interface [polypeptide binding]; other site 710686008867 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686008868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008870 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710686008871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686008872 ABC transporter; Region: ABC_tran_2; pfam12848 710686008873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686008874 acyl-CoA synthetase; Validated; Region: PRK07868 710686008875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686008876 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686008877 active site 710686008878 CoA binding site [chemical binding]; other site 710686008879 AMP binding site [chemical binding]; other site 710686008880 Uncharacterized conserved protein [Function unknown]; Region: COG2835 710686008881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008883 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686008884 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686008885 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710686008886 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710686008887 Walker A/P-loop; other site 710686008888 ATP binding site [chemical binding]; other site 710686008889 Q-loop/lid; other site 710686008890 ABC transporter signature motif; other site 710686008891 Walker B; other site 710686008892 D-loop; other site 710686008893 H-loop/switch region; other site 710686008894 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 710686008895 active site 710686008896 DNA binding site [nucleotide binding] 710686008897 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710686008898 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710686008899 active site 710686008900 HIGH motif; other site 710686008901 dimer interface [polypeptide binding]; other site 710686008902 KMSKS motif; other site 710686008903 S4 RNA-binding domain; Region: S4; smart00363 710686008904 Tetratrico peptide repeat; Region: TPR_5; pfam12688 710686008905 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710686008906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686008907 active site 710686008908 motif I; other site 710686008909 motif II; other site 710686008910 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710686008911 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 710686008912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710686008913 RNA binding surface [nucleotide binding]; other site 710686008914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686008915 S-adenosylmethionine binding site [chemical binding]; other site 710686008916 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 710686008917 ATP-NAD kinase; Region: NAD_kinase; pfam01513 710686008918 DNA repair protein RecN; Region: recN; TIGR00634 710686008919 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710686008920 Walker A/P-loop; other site 710686008921 ATP binding site [chemical binding]; other site 710686008922 Q-loop/lid; other site 710686008923 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710686008924 ABC transporter signature motif; other site 710686008925 Walker B; other site 710686008926 D-loop; other site 710686008927 H-loop/switch region; other site 710686008928 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 710686008929 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 710686008930 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 710686008931 CTP synthetase; Validated; Region: pyrG; PRK05380 710686008932 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 710686008933 Catalytic site [active] 710686008934 active site 710686008935 UTP binding site [chemical binding]; other site 710686008936 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710686008937 active site 710686008938 putative oxyanion hole; other site 710686008939 catalytic triad [active] 710686008940 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710686008941 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710686008942 dimer interface [polypeptide binding]; other site 710686008943 ADP-ribose binding site [chemical binding]; other site 710686008944 active site 710686008945 nudix motif; other site 710686008946 metal binding site [ion binding]; metal-binding site 710686008947 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 710686008948 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 710686008949 active site 710686008950 Int/Topo IB signature motif; other site 710686008951 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710686008952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710686008953 S-adenosylmethionine binding site [chemical binding]; other site 710686008954 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686008955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686008956 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686008957 Magnesium ion binding site [ion binding]; other site 710686008958 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 710686008959 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 710686008960 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 710686008961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710686008962 RNA binding surface [nucleotide binding]; other site 710686008963 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 710686008964 active site 710686008965 cytidylate kinase; Provisional; Region: cmk; PRK00023 710686008966 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 710686008967 CMP-binding site; other site 710686008968 The sites determining sugar specificity; other site 710686008969 GTP-binding protein Der; Reviewed; Region: PRK03003 710686008970 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 710686008971 G1 box; other site 710686008972 GTP/Mg2+ binding site [chemical binding]; other site 710686008973 Switch I region; other site 710686008974 G2 box; other site 710686008975 Switch II region; other site 710686008976 G3 box; other site 710686008977 G4 box; other site 710686008978 G5 box; other site 710686008979 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 710686008980 G1 box; other site 710686008981 GTP/Mg2+ binding site [chemical binding]; other site 710686008982 Switch I region; other site 710686008983 G2 box; other site 710686008984 G3 box; other site 710686008985 Switch II region; other site 710686008986 G4 box; other site 710686008987 G5 box; other site 710686008988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710686008989 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710686008990 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710686008991 catalytic residue [active] 710686008992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686008993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686008994 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710686008995 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 710686008996 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 710686008997 Predicted esterase [General function prediction only]; Region: COG0627 710686008998 Cutinase; Region: Cutinase; pfam01083 710686008999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686009000 S-adenosylmethionine binding site [chemical binding]; other site 710686009001 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 710686009002 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686009003 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686009004 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686009005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009007 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686009008 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686009009 [2Fe-2S] cluster binding site [ion binding]; other site 710686009010 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686009011 hydrophobic ligand binding site; other site 710686009012 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 710686009013 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686009014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686009015 substrate binding site [chemical binding]; other site 710686009016 oxyanion hole (OAH) forming residues; other site 710686009017 trimer interface [polypeptide binding]; other site 710686009018 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686009019 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686009020 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710686009021 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686009022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686009023 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710686009024 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710686009025 FAD binding site [chemical binding]; other site 710686009026 substrate binding site [chemical binding]; other site 710686009027 catalytic base [active] 710686009028 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686009029 classical (c) SDRs; Region: SDR_c; cd05233 710686009030 NAD(P) binding site [chemical binding]; other site 710686009031 active site 710686009032 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 710686009033 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710686009034 tetramer interface [polypeptide binding]; other site 710686009035 TPP-binding site [chemical binding]; other site 710686009036 heterodimer interface [polypeptide binding]; other site 710686009037 phosphorylation loop region [posttranslational modification] 710686009038 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710686009039 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710686009040 alpha subunit interface [polypeptide binding]; other site 710686009041 TPP binding site [chemical binding]; other site 710686009042 heterodimer interface [polypeptide binding]; other site 710686009043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686009044 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686009045 E3 interaction surface; other site 710686009046 lipoyl attachment site [posttranslational modification]; other site 710686009047 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686009048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686009049 substrate binding site [chemical binding]; other site 710686009050 oxyanion hole (OAH) forming residues; other site 710686009051 trimer interface [polypeptide binding]; other site 710686009052 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710686009053 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686009054 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686009055 acyl-activating enzyme (AAE) consensus motif; other site 710686009056 putative AMP binding site [chemical binding]; other site 710686009057 putative active site [active] 710686009058 acyl-activating enzyme (AAE) consensus motif; other site 710686009059 putative CoA binding site [chemical binding]; other site 710686009060 acyl-CoA synthetase; Provisional; Region: PRK13388 710686009061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686009062 acyl-activating enzyme (AAE) consensus motif; other site 710686009063 AMP binding site [chemical binding]; other site 710686009064 active site 710686009065 CoA binding site [chemical binding]; other site 710686009066 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686009067 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710686009068 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686009069 NAD binding site [chemical binding]; other site 710686009070 catalytic Zn binding site [ion binding]; other site 710686009071 substrate binding site [chemical binding]; other site 710686009072 structural Zn binding site [ion binding]; other site 710686009073 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686009074 Cytochrome P450; Region: p450; cl12078 710686009075 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 710686009076 iron-sulfur cluster [ion binding]; other site 710686009077 [2Fe-2S] cluster binding site [ion binding]; other site 710686009078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009080 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710686009081 classical (c) SDRs; Region: SDR_c; cd05233 710686009082 NAD(P) binding site [chemical binding]; other site 710686009083 active site 710686009084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686009085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686009086 DNA-binding site [nucleotide binding]; DNA binding site 710686009087 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686009088 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686009089 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686009090 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686009091 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686009092 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686009093 Cytochrome P450; Region: p450; cl12078 710686009094 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686009095 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686009096 [2Fe-2S] cluster binding site [ion binding]; other site 710686009097 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686009098 hydrophobic ligand binding site; other site 710686009099 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 710686009100 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 710686009101 acyl-activating enzyme (AAE) consensus motif; other site 710686009102 putative AMP binding site [chemical binding]; other site 710686009103 putative active site [active] 710686009104 putative CoA binding site [chemical binding]; other site 710686009105 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686009106 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686009107 active site 710686009108 catalytic site [active] 710686009109 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686009110 active site 2 [active] 710686009111 active site 1 [active] 710686009112 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710686009113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686009114 NAD binding site [chemical binding]; other site 710686009115 catalytic residues [active] 710686009116 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686009117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686009118 iron-sulfur cluster [ion binding]; other site 710686009119 [2Fe-2S] cluster binding site [ion binding]; other site 710686009120 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 710686009121 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686009122 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686009123 [2Fe-2S] cluster binding site [ion binding]; other site 710686009124 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 710686009125 putative alpha subunit interface [polypeptide binding]; other site 710686009126 putative active site [active] 710686009127 putative substrate binding site [chemical binding]; other site 710686009128 Fe binding site [ion binding]; other site 710686009129 Predicted esterase [General function prediction only]; Region: COG0627 710686009130 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686009131 hydrophobic ligand binding site; other site 710686009132 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710686009133 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686009134 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710686009135 active site 710686009136 catalytic triad [active] 710686009137 oxyanion hole [active] 710686009138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009140 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686009141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686009142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009144 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710686009145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686009146 Walker A/P-loop; other site 710686009147 ATP binding site [chemical binding]; other site 710686009148 Q-loop/lid; other site 710686009149 ABC transporter signature motif; other site 710686009150 Walker B; other site 710686009151 D-loop; other site 710686009152 H-loop/switch region; other site 710686009153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686009154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686009155 Walker A/P-loop; other site 710686009156 ATP binding site [chemical binding]; other site 710686009157 Q-loop/lid; other site 710686009158 ABC transporter signature motif; other site 710686009159 Walker B; other site 710686009160 D-loop; other site 710686009161 H-loop/switch region; other site 710686009162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686009163 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710686009164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009165 ABC-ATPase subunit interface; other site 710686009166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710686009167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009168 dimer interface [polypeptide binding]; other site 710686009169 conserved gate region; other site 710686009170 putative PBP binding loops; other site 710686009171 ABC-ATPase subunit interface; other site 710686009172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710686009173 catalytic triad [active] 710686009174 Isochorismatase family; Region: Isochorismatase; pfam00857 710686009175 conserved cis-peptide bond; other site 710686009176 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 710686009177 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710686009178 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710686009179 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009180 allantoinase; Region: allantoinase; TIGR03178 710686009181 active site 710686009182 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 710686009183 allantoicase; Provisional; Region: PRK13257 710686009184 Allantoicase repeat; Region: Allantoicase; pfam03561 710686009185 Allantoicase repeat; Region: Allantoicase; pfam03561 710686009186 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 710686009187 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 710686009188 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 710686009189 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 710686009190 Prostaglandin dehydrogenases; Region: PGDH; cd05288 710686009191 NAD(P) binding site [chemical binding]; other site 710686009192 substrate binding site [chemical binding]; other site 710686009193 dimer interface [polypeptide binding]; other site 710686009194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710686009195 nudix motif; other site 710686009196 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686009197 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009198 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686009199 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710686009200 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686009201 metal ion-dependent adhesion site (MIDAS); other site 710686009202 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 710686009203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686009204 HAMP domain; Region: HAMP; pfam00672 710686009205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686009206 dimer interface [polypeptide binding]; other site 710686009207 phosphorylation site [posttranslational modification] 710686009208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686009209 ATP binding site [chemical binding]; other site 710686009210 Mg2+ binding site [ion binding]; other site 710686009211 G-X-G motif; other site 710686009212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686009213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686009214 active site 710686009215 phosphorylation site [posttranslational modification] 710686009216 intermolecular recognition site; other site 710686009217 dimerization interface [polypeptide binding]; other site 710686009218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686009219 DNA binding site [nucleotide binding] 710686009220 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 710686009221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686009222 putative substrate translocation pore; other site 710686009223 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 710686009224 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 710686009225 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 710686009226 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686009227 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710686009228 putative acyl-acceptor binding pocket; other site 710686009229 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686009230 hydrophobic ligand binding site; other site 710686009231 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 710686009232 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 710686009233 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710686009234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710686009235 active site 710686009236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686009237 substrate binding site [chemical binding]; other site 710686009238 catalytic residues [active] 710686009239 dimer interface [polypeptide binding]; other site 710686009240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686009243 protochlorophyllide reductase; Region: PLN00015 710686009244 NAD(P) binding site [chemical binding]; other site 710686009245 active site 710686009246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686009247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686009248 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710686009249 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 710686009250 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710686009251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686009252 substrate binding pocket [chemical binding]; other site 710686009253 catalytic triad [active] 710686009254 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 710686009255 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710686009256 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 710686009257 TrkA-C domain; Region: TrkA_C; pfam02080 710686009258 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 710686009259 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710686009260 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710686009261 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686009262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686009263 dimerization interface [polypeptide binding]; other site 710686009264 putative DNA binding site [nucleotide binding]; other site 710686009265 putative Zn2+ binding site [ion binding]; other site 710686009266 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710686009267 metal binding site [ion binding]; metal-binding site 710686009268 substrate binding site [chemical binding]; other site 710686009269 dimer interface [polypeptide binding]; other site 710686009270 hypothetical protein; Validated; Region: PRK07121 710686009271 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686009272 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710686009273 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710686009274 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710686009275 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710686009276 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710686009277 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710686009278 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710686009279 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710686009280 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710686009281 hypothetical protein; Provisional; Region: PRK05858 710686009282 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686009283 PYR/PP interface [polypeptide binding]; other site 710686009284 dimer interface [polypeptide binding]; other site 710686009285 TPP binding site [chemical binding]; other site 710686009286 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686009287 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710686009288 TPP-binding site; other site 710686009289 dimer interface [polypeptide binding]; other site 710686009290 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710686009291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 710686009292 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 710686009293 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 710686009294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686009295 nucleotide binding region [chemical binding]; other site 710686009296 ATP-binding site [chemical binding]; other site 710686009297 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710686009298 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710686009299 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 710686009300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710686009301 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710686009302 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 710686009303 lipoyl attachment site [posttranslational modification]; other site 710686009304 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686009305 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686009306 phosphopeptide binding site; other site 710686009307 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 710686009308 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686009309 DNA binding residues [nucleotide binding] 710686009310 Bifunctional nuclease; Region: DNase-RNase; pfam02577 710686009311 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 710686009312 DNA binding residues [nucleotide binding] 710686009313 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686009314 putative dimer interface [polypeptide binding]; other site 710686009315 glycine dehydrogenase; Provisional; Region: PRK05367 710686009316 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710686009317 tetramer interface [polypeptide binding]; other site 710686009318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686009319 catalytic residue [active] 710686009320 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710686009321 tetramer interface [polypeptide binding]; other site 710686009322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686009323 catalytic residue [active] 710686009324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686009325 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686009326 metal ion-dependent adhesion site (MIDAS); other site 710686009327 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 710686009328 active site 710686009329 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710686009330 Domain of unknown function DUF21; Region: DUF21; pfam01595 710686009331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710686009332 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710686009333 Domain of unknown function DUF21; Region: DUF21; pfam01595 710686009334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710686009335 Transporter associated domain; Region: CorC_HlyC; smart01091 710686009336 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 710686009337 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686009338 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710686009339 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710686009340 active site 710686009341 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686009342 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 710686009343 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 710686009344 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 710686009345 Predicted transcriptional regulator [Transcription]; Region: COG3682 710686009346 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686009347 CoenzymeA binding site [chemical binding]; other site 710686009348 subunit interaction site [polypeptide binding]; other site 710686009349 PHB binding site; other site 710686009350 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 710686009351 alpha-gamma subunit interface [polypeptide binding]; other site 710686009352 beta-gamma subunit interface [polypeptide binding]; other site 710686009353 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 710686009354 alpha-beta subunit interface [polypeptide binding]; other site 710686009355 urease subunit alpha; Reviewed; Region: ureC; PRK13206 710686009356 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 710686009357 subunit interactions [polypeptide binding]; other site 710686009358 active site 710686009359 flap region; other site 710686009360 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 710686009361 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686009362 UreD urease accessory protein; Region: UreD; cl00530 710686009363 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686009364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686009365 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009366 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686009367 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710686009368 classical (c) SDRs; Region: SDR_c; cd05233 710686009369 NAD(P) binding site [chemical binding]; other site 710686009370 active site 710686009371 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710686009372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009373 putative PBP binding loops; other site 710686009374 ABC-ATPase subunit interface; other site 710686009375 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 710686009376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686009377 Walker A/P-loop; other site 710686009378 ATP binding site [chemical binding]; other site 710686009379 Q-loop/lid; other site 710686009380 ABC transporter signature motif; other site 710686009381 Walker B; other site 710686009382 D-loop; other site 710686009383 H-loop/switch region; other site 710686009384 TOBE domain; Region: TOBE; pfam03459 710686009385 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 710686009386 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 710686009387 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 710686009388 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 710686009389 putative NAD(P) binding site [chemical binding]; other site 710686009390 putative substrate binding site [chemical binding]; other site 710686009391 catalytic Zn binding site [ion binding]; other site 710686009392 structural Zn binding site [ion binding]; other site 710686009393 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710686009394 CGNR zinc finger; Region: zf-CGNR; pfam11706 710686009395 CAAX protease self-immunity; Region: Abi; pfam02517 710686009396 putative phosphoketolase; Provisional; Region: PRK05261 710686009397 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 710686009398 TPP-binding site; other site 710686009399 XFP C-terminal domain; Region: XFP_C; pfam09363 710686009400 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686009401 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009402 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686009403 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686009404 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686009405 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686009406 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710686009407 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686009408 active site 710686009409 short chain dehydrogenase; Provisional; Region: PRK12937 710686009410 classical (c) SDRs; Region: SDR_c; cd05233 710686009411 NAD(P) binding site [chemical binding]; other site 710686009412 active site 710686009413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710686009414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686009415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686009416 Protein of unknown function DUF72; Region: DUF72; pfam01904 710686009417 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 710686009418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686009419 Walker A motif; other site 710686009420 ATP binding site [chemical binding]; other site 710686009421 Walker B motif; other site 710686009422 arginine finger; other site 710686009423 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710686009424 Predicted esterase [General function prediction only]; Region: COG0627 710686009425 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 710686009426 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710686009427 active site 710686009428 substrate binding site [chemical binding]; other site 710686009429 FMN binding site [chemical binding]; other site 710686009430 putative catalytic residues [active] 710686009431 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710686009432 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710686009433 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686009434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686009435 ligand binding site [chemical binding]; other site 710686009436 flexible hinge region; other site 710686009437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686009438 dimerization interface [polypeptide binding]; other site 710686009439 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686009440 cyclase homology domain; Region: CHD; cd07302 710686009441 nucleotidyl binding site; other site 710686009442 metal binding site [ion binding]; metal-binding site 710686009443 dimer interface [polypeptide binding]; other site 710686009444 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 710686009445 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 710686009446 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710686009447 active site 710686009448 catalytic site [active] 710686009449 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710686009450 nucleoside/Zn binding site; other site 710686009451 dimer interface [polypeptide binding]; other site 710686009452 catalytic motif [active] 710686009453 TPR repeat; Region: TPR_11; pfam13414 710686009454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710686009455 binding surface 710686009456 TPR motif; other site 710686009457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 710686009458 binding surface 710686009459 TPR motif; other site 710686009460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009462 DoxX-like family; Region: DoxX_2; pfam13564 710686009463 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 710686009464 Isochorismatase family; Region: Isochorismatase; pfam00857 710686009465 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710686009466 catalytic triad [active] 710686009467 conserved cis-peptide bond; other site 710686009468 hypothetical protein; Provisional; Region: PRK06102 710686009469 Amidase; Region: Amidase; cl11426 710686009470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686009471 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 710686009472 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686009473 FAD binding domain; Region: FAD_binding_3; pfam01494 710686009474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009476 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710686009477 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 710686009478 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710686009479 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 710686009480 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710686009481 EthD domain; Region: EthD; cl17553 710686009482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686009483 substrate binding site [chemical binding]; other site 710686009484 oxyanion hole (OAH) forming residues; other site 710686009485 trimer interface [polypeptide binding]; other site 710686009486 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686009487 Phosphotransferase enzyme family; Region: APH; pfam01636 710686009488 putative active site [active] 710686009489 putative substrate binding site [chemical binding]; other site 710686009490 ATP binding site [chemical binding]; other site 710686009491 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 710686009492 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 710686009493 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 710686009494 heme binding site [chemical binding]; other site 710686009495 ferroxidase pore; other site 710686009496 ferroxidase diiron center [ion binding]; other site 710686009497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686009498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686009499 putative substrate translocation pore; other site 710686009500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686009501 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710686009502 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710686009503 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686009504 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710686009505 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009506 active site 710686009507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009508 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686009509 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710686009510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009512 short chain dehydrogenase; Provisional; Region: PRK08303 710686009513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686009514 NAD(P) binding site [chemical binding]; other site 710686009515 active site 710686009516 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710686009517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686009518 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710686009519 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710686009520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686009521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686009522 DNA binding site [nucleotide binding] 710686009523 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 710686009524 Amino acid permease; Region: AA_permease_2; pfam13520 710686009525 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710686009526 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710686009527 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686009528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009529 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 710686009530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686009531 active site 710686009532 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710686009533 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 710686009534 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 710686009535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686009536 motif II; other site 710686009537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009538 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710686009539 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686009540 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686009541 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686009542 Cytochrome P450; Region: p450; cl12078 710686009543 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686009544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686009545 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686009546 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686009547 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686009548 hydrophobic ligand binding site; other site 710686009549 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686009550 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686009551 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 710686009552 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009553 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 710686009554 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686009555 catalytic residues [active] 710686009556 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710686009557 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 710686009558 chorismate mutase; Provisional; Region: PRK09269 710686009559 chorismate mutase, putative; Region: CM_mono2; TIGR01806 710686009560 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 710686009561 Putative esterase; Region: Esterase; pfam00756 710686009562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686009563 MarR family; Region: MarR_2; pfam12802 710686009564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686009565 Coenzyme A binding pocket [chemical binding]; other site 710686009566 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686009567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686009568 S-adenosylmethionine binding site [chemical binding]; other site 710686009569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686009570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009572 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 710686009573 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 710686009574 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686009575 classical (c) SDRs; Region: SDR_c; cd05233 710686009576 NAD(P) binding site [chemical binding]; other site 710686009577 active site 710686009578 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 710686009579 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 710686009580 DNA binding residues [nucleotide binding] 710686009581 dimer interface [polypeptide binding]; other site 710686009582 [2Fe-2S] cluster binding site [ion binding]; other site 710686009583 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 710686009584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686009585 Coenzyme A binding pocket [chemical binding]; other site 710686009586 Protein of unknown function, DUF393; Region: DUF393; pfam04134 710686009587 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 710686009588 agmatinase; Region: agmatinase; TIGR01230 710686009589 Agmatinase-like family; Region: Agmatinase-like; cd09990 710686009590 active site 710686009591 oligomer interface [polypeptide binding]; other site 710686009592 Mn binding site [ion binding]; other site 710686009593 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710686009594 active site 710686009595 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 710686009596 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710686009597 tetramer interface [polypeptide binding]; other site 710686009598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686009599 catalytic residue [active] 710686009600 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 710686009601 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 710686009602 POT family; Region: PTR2; cl17359 710686009603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686009604 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686009605 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686009606 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 710686009607 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686009608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686009609 DNA-binding site [nucleotide binding]; DNA binding site 710686009610 FCD domain; Region: FCD; cl11656 710686009611 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686009612 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686009613 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710686009614 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 710686009615 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710686009616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686009617 sequence-specific DNA binding site [nucleotide binding]; other site 710686009618 salt bridge; other site 710686009619 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686009620 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686009621 Cytochrome P450; Region: p450; cl12078 710686009622 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 710686009623 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 710686009624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009626 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686009627 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686009628 molybdopterin cofactor binding site; other site 710686009629 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686009630 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710686009631 putative molybdopterin cofactor binding site; other site 710686009632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009634 Helix-turn-helix domain; Region: HTH_38; pfam13936 710686009635 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710686009636 Integrase core domain; Region: rve; pfam00665 710686009637 Nitronate monooxygenase; Region: NMO; pfam03060 710686009638 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686009639 FMN binding site [chemical binding]; other site 710686009640 substrate binding site [chemical binding]; other site 710686009641 putative catalytic residue [active] 710686009642 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710686009643 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710686009644 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686009645 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710686009646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686009647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686009648 NAD(P) binding site [chemical binding]; other site 710686009649 active site 710686009650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686009651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686009652 catalytic residue [active] 710686009653 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 710686009654 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 710686009655 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 710686009656 Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198 710686009657 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686009658 CoenzymeA binding site [chemical binding]; other site 710686009659 subunit interaction site [polypeptide binding]; other site 710686009660 PHB binding site; other site 710686009661 competence damage-inducible protein A; Provisional; Region: PRK00549 710686009662 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 710686009663 putative MPT binding site; other site 710686009664 Competence-damaged protein; Region: CinA; pfam02464 710686009665 Biofilm formation and stress response factor; Region: BsmA; pfam10014 710686009666 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 710686009667 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710686009668 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 710686009669 putative ADP-ribose binding site [chemical binding]; other site 710686009670 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; Region: ACT_PDH-BS-like; cd04889 710686009671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710686009672 hypothetical protein; Provisional; Region: PRK01346 710686009673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686009674 Coenzyme A binding pocket [chemical binding]; other site 710686009675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686009676 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 710686009677 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710686009678 Amidase; Region: Amidase; cl11426 710686009679 Amidase; Region: Amidase; cl11426 710686009680 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 710686009681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686009682 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710686009683 dimer interface [polypeptide binding]; other site 710686009684 acyl-activating enzyme (AAE) consensus motif; other site 710686009685 putative active site [active] 710686009686 AMP binding site [chemical binding]; other site 710686009687 putative CoA binding site [chemical binding]; other site 710686009688 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710686009689 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 710686009690 hypothetical protein; Validated; Region: PRK02101 710686009691 NlpC/P60 family; Region: NLPC_P60; cl17555 710686009692 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710686009693 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686009694 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 710686009695 DNA binding site [nucleotide binding] 710686009696 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710686009697 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686009698 cyclase homology domain; Region: CHD; cd07302 710686009699 nucleotidyl binding site; other site 710686009700 metal binding site [ion binding]; metal-binding site 710686009701 dimer interface [polypeptide binding]; other site 710686009702 Predicted ATPase [General function prediction only]; Region: COG3899 710686009703 AAA ATPase domain; Region: AAA_16; pfam13191 710686009704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686009705 dimerization interface [polypeptide binding]; other site 710686009706 putative DNA binding site [nucleotide binding]; other site 710686009707 putative Zn2+ binding site [ion binding]; other site 710686009708 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 710686009709 putative hydrophobic ligand binding site [chemical binding]; other site 710686009710 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710686009711 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710686009712 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710686009713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686009714 active site 710686009715 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 710686009716 hypothetical protein; Validated; Region: PRK07198 710686009717 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 710686009718 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710686009719 dimerization interface [polypeptide binding]; other site 710686009720 active site 710686009721 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710686009722 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686009723 active site 710686009724 catalytic triad [active] 710686009725 oxyanion hole [active] 710686009726 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 710686009727 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 710686009728 heme binding site [chemical binding]; other site 710686009729 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 710686009730 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710686009731 metal binding site 2 [ion binding]; metal-binding site 710686009732 putative DNA binding helix; other site 710686009733 metal binding site 1 [ion binding]; metal-binding site 710686009734 dimer interface [polypeptide binding]; other site 710686009735 structural Zn2+ binding site [ion binding]; other site 710686009736 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710686009737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009738 dimer interface [polypeptide binding]; other site 710686009739 conserved gate region; other site 710686009740 putative PBP binding loops; other site 710686009741 ABC-ATPase subunit interface; other site 710686009742 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710686009743 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 710686009744 Walker A/P-loop; other site 710686009745 ATP binding site [chemical binding]; other site 710686009746 Q-loop/lid; other site 710686009747 ABC transporter signature motif; other site 710686009748 Walker B; other site 710686009749 D-loop; other site 710686009750 H-loop/switch region; other site 710686009751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686009752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710686009753 substrate binding pocket [chemical binding]; other site 710686009754 membrane-bound complex binding site; other site 710686009755 hinge residues; other site 710686009756 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686009757 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686009758 active site 710686009759 non-prolyl cis peptide bond; other site 710686009760 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686009761 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686009762 active site 710686009763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686009764 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 710686009765 putative NAD(P) binding site [chemical binding]; other site 710686009766 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710686009767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009768 Transport protein; Region: actII; TIGR00833 710686009769 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 710686009770 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686009771 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686009772 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686009773 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686009774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686009775 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710686009776 Walker A/P-loop; other site 710686009777 ATP binding site [chemical binding]; other site 710686009778 Q-loop/lid; other site 710686009779 ABC transporter signature motif; other site 710686009780 Walker B; other site 710686009781 D-loop; other site 710686009782 H-loop/switch region; other site 710686009783 Condensation domain; Region: Condensation; pfam00668 710686009784 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710686009785 catalytic triad [active] 710686009786 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686009787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686009788 S-adenosylmethionine binding site [chemical binding]; other site 710686009789 Transport protein; Region: actII; TIGR00833 710686009790 Transport protein; Region: actII; TIGR00833 710686009791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686009792 PAS domain; Region: PAS_9; pfam13426 710686009793 putative active site [active] 710686009794 heme pocket [chemical binding]; other site 710686009795 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710686009796 tetramer interface [polypeptide binding]; other site 710686009797 active site 710686009798 Mg2+/Mn2+ binding site [ion binding]; other site 710686009799 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 710686009800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686009801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686009802 dimer interface [polypeptide binding]; other site 710686009803 phosphorylation site [posttranslational modification] 710686009804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686009805 ATP binding site [chemical binding]; other site 710686009806 Mg2+ binding site [ion binding]; other site 710686009807 G-X-G motif; other site 710686009808 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686009809 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686009810 prolyl-tRNA synthetase; Provisional; Region: PRK08661 710686009811 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 710686009812 dimer interface [polypeptide binding]; other site 710686009813 motif 1; other site 710686009814 active site 710686009815 motif 2; other site 710686009816 motif 3; other site 710686009817 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 710686009818 anticodon binding site; other site 710686009819 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 710686009820 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686009821 hydrophobic ligand binding site; other site 710686009822 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710686009823 FMN binding site [chemical binding]; other site 710686009824 dimer interface [polypeptide binding]; other site 710686009825 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686009826 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686009827 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686009828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686009829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686009830 acyl-activating enzyme (AAE) consensus motif; other site 710686009831 acyl-activating enzyme (AAE) consensus motif; other site 710686009832 AMP binding site [chemical binding]; other site 710686009833 active site 710686009834 CoA binding site [chemical binding]; other site 710686009835 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686009836 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686009837 active site 710686009838 ATP binding site [chemical binding]; other site 710686009839 substrate binding site [chemical binding]; other site 710686009840 activation loop (A-loop); other site 710686009841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686009842 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686009843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686009844 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686009845 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710686009846 RibD C-terminal domain; Region: RibD_C; cl17279 710686009847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686009848 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 710686009849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710686009850 MOSC domain; Region: MOSC; pfam03473 710686009851 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686009852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686009853 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686009854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686009855 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 710686009856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686009857 Walker A/P-loop; other site 710686009858 ATP binding site [chemical binding]; other site 710686009859 Q-loop/lid; other site 710686009860 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710686009861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686009862 Walker A/P-loop; other site 710686009863 ATP binding site [chemical binding]; other site 710686009864 Q-loop/lid; other site 710686009865 ABC transporter signature motif; other site 710686009866 Walker B; other site 710686009867 D-loop; other site 710686009868 H-loop/switch region; other site 710686009869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686009870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710686009871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686009872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686009873 Phosphoesterase family; Region: Phosphoesterase; pfam04185 710686009874 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710686009875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686009876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686009877 NAD(P) binding site [chemical binding]; other site 710686009878 active site 710686009879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009881 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 710686009882 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 710686009883 putative active site [active] 710686009884 putative metal binding site [ion binding]; other site 710686009885 TspO/MBR family; Region: TspO_MBR; pfam03073 710686009886 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686009887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686009888 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710686009889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686009890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686009891 DNA binding residues [nucleotide binding] 710686009892 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686009893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686009894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686009895 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686009896 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686009897 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 710686009898 homodimer interface [polypeptide binding]; other site 710686009899 homotetramer interface [polypeptide binding]; other site 710686009900 active site pocket [active] 710686009901 cleavage site 710686009902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686009903 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686009904 hydrophobic ligand binding site; other site 710686009905 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 710686009906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710686009907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009908 dimer interface [polypeptide binding]; other site 710686009909 conserved gate region; other site 710686009910 putative PBP binding loops; other site 710686009911 ABC-ATPase subunit interface; other site 710686009912 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710686009913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686009914 dimer interface [polypeptide binding]; other site 710686009915 conserved gate region; other site 710686009916 putative PBP binding loops; other site 710686009917 ABC-ATPase subunit interface; other site 710686009918 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 710686009919 EamA-like transporter family; Region: EamA; pfam00892 710686009920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686009921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686009922 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 710686009923 putative dimerization interface [polypeptide binding]; other site 710686009924 Helix-turn-helix domain; Region: HTH_31; pfam13560 710686009925 salt bridge; other site 710686009926 non-specific DNA binding site [nucleotide binding]; other site 710686009927 sequence-specific DNA binding site [nucleotide binding]; other site 710686009928 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686009929 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686009930 short chain dehydrogenase; Provisional; Region: PRK06500 710686009931 classical (c) SDRs; Region: SDR_c; cd05233 710686009932 NAD(P) binding site [chemical binding]; other site 710686009933 active site 710686009934 classical (c) SDRs; Region: SDR_c; cd05233 710686009935 NAD(P) binding site [chemical binding]; other site 710686009936 active site 710686009937 Domain of unknown function (DUF427); Region: DUF427; cl00998 710686009938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710686009939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686009940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686009941 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686009942 short chain dehydrogenase; Provisional; Region: PRK06500 710686009943 classical (c) SDRs; Region: SDR_c; cd05233 710686009944 NAD(P) binding site [chemical binding]; other site 710686009945 active site 710686009946 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686009947 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686009948 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686009949 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686009950 classical (c) SDRs; Region: SDR_c; cd05233 710686009951 NAD(P) binding site [chemical binding]; other site 710686009952 active site 710686009953 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 710686009954 active site 710686009955 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686009956 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686009957 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686009958 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686009959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710686009960 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710686009961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686009962 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 710686009963 multimer interface [polypeptide binding]; other site 710686009964 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710686009965 active site 710686009966 catalytic triad [active] 710686009967 protein interface 1 [polypeptide binding]; other site 710686009968 putative acyltransferase; Provisional; Region: PRK05790 710686009969 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686009970 dimer interface [polypeptide binding]; other site 710686009971 active site 710686009972 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686009973 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 710686009974 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686009975 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 710686009976 FAD binding pocket [chemical binding]; other site 710686009977 FAD binding motif [chemical binding]; other site 710686009978 phosphate binding motif [ion binding]; other site 710686009979 beta-alpha-beta structure motif; other site 710686009980 NAD binding pocket [chemical binding]; other site 710686009981 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710686009982 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 710686009983 Moco binding site; other site 710686009984 metal coordination site [ion binding]; other site 710686009985 Protein of unknown function (DUF421); Region: DUF421; pfam04239 710686009986 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710686009987 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710686009988 D-pathway; other site 710686009989 Putative ubiquinol binding site [chemical binding]; other site 710686009990 Low-spin heme (heme b) binding site [chemical binding]; other site 710686009991 Putative water exit pathway; other site 710686009992 Binuclear center (heme o3/CuB) [ion binding]; other site 710686009993 K-pathway; other site 710686009994 Putative proton exit pathway; other site 710686009995 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710686009996 putative active site [active] 710686009997 transaldolase; Provisional; Region: PRK03903 710686009998 catalytic residue [active] 710686009999 methionine sulfoxide reductase A; Provisional; Region: PRK14054 710686010000 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710686010001 SelR domain; Region: SelR; pfam01641 710686010002 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686010003 classical (c) SDRs; Region: SDR_c; cd05233 710686010004 NAD(P) binding site [chemical binding]; other site 710686010005 active site 710686010006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686010007 Coenzyme A binding pocket [chemical binding]; other site 710686010008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686010009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686010010 catalytic residues [active] 710686010011 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710686010012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686010013 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 710686010014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686010015 DNA binding residues [nucleotide binding] 710686010016 AAA ATPase domain; Region: AAA_16; pfam13191 710686010017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686010018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686010019 DNA binding residues [nucleotide binding] 710686010020 dimerization interface [polypeptide binding]; other site 710686010021 Predicted ATPase [General function prediction only]; Region: COG3899 710686010022 AAA ATPase domain; Region: AAA_16; pfam13191 710686010023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686010024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686010025 DNA binding residues [nucleotide binding] 710686010026 dimerization interface [polypeptide binding]; other site 710686010027 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686010028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686010029 NAD(P) binding site [chemical binding]; other site 710686010030 active site 710686010031 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686010032 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686010033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710686010034 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686010035 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710686010036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686010037 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686010038 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686010039 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 710686010040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686010041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686010042 Protein of unknown function, DUF417; Region: DUF417; cl01162 710686010043 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710686010044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686010045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686010046 DNA binding residues [nucleotide binding] 710686010047 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710686010048 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686010049 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710686010050 putative NAD(P) binding site [chemical binding]; other site 710686010051 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710686010052 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710686010053 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 710686010054 GAF domain; Region: GAF; pfam01590 710686010055 GAF domain; Region: GAF_2; pfam13185 710686010056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686010057 Histidine kinase; Region: HisKA_3; pfam07730 710686010058 acyl-CoA synthetase; Validated; Region: PRK05852 710686010059 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686010060 acyl-activating enzyme (AAE) consensus motif; other site 710686010061 AMP binding site [chemical binding]; other site 710686010062 active site 710686010063 CoA binding site [chemical binding]; other site 710686010064 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710686010065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686010066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686010067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 710686010068 dimerization interface [polypeptide binding]; other site 710686010069 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710686010070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686010071 active site 710686010072 phosphorylation site [posttranslational modification] 710686010073 intermolecular recognition site; other site 710686010074 sulfite oxidase; Provisional; Region: PLN00177 710686010075 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 710686010076 Moco binding site; other site 710686010077 metal coordination site [ion binding]; other site 710686010078 dimerization interface [polypeptide binding]; other site 710686010079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686010080 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 710686010081 active site 710686010082 phosphorylation site [posttranslational modification] 710686010083 intermolecular recognition site; other site 710686010084 dimerization interface [polypeptide binding]; other site 710686010085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686010086 DNA binding residues [nucleotide binding] 710686010087 dimerization interface [polypeptide binding]; other site 710686010088 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686010089 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686010090 active site 710686010091 catalytic tetrad [active] 710686010092 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 710686010093 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 710686010094 tetramer interface [polypeptide binding]; other site 710686010095 heme binding pocket [chemical binding]; other site 710686010096 NADPH binding site [chemical binding]; other site 710686010097 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 710686010098 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 710686010099 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710686010100 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686010101 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686010102 classical (c) SDRs; Region: SDR_c; cd05233 710686010103 NAD(P) binding site [chemical binding]; other site 710686010104 active site 710686010105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686010106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686010107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710686010108 dimerization interface [polypeptide binding]; other site 710686010109 mercuric reductase; Validated; Region: PRK06370 710686010110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686010111 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686010112 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710686010113 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 710686010114 putative heme binding pocket [chemical binding]; other site 710686010115 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 710686010116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686010117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686010118 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 710686010119 putative catalytic residues [active] 710686010120 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 710686010121 acyl-coenzyme A oxidase; Region: PLN02526 710686010122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686010123 active site 710686010124 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 710686010125 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710686010126 putative active site [active] 710686010127 putative catalytic site [active] 710686010128 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 710686010129 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 710686010130 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710686010131 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 710686010132 acyl-activating enzyme (AAE) consensus motif; other site 710686010133 putative AMP binding site [chemical binding]; other site 710686010134 putative active site [active] 710686010135 putative CoA binding site [chemical binding]; other site 710686010136 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 710686010137 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 710686010138 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686010139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686010140 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686010141 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 710686010142 acyl-activating enzyme (AAE) consensus motif; other site 710686010143 putative AMP binding site [chemical binding]; other site 710686010144 putative active site [active] 710686010145 putative CoA binding site [chemical binding]; other site 710686010146 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 710686010147 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710686010148 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686010149 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686010150 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710686010151 putative NAD(P) binding site [chemical binding]; other site 710686010152 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686010153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686010154 S-adenosylmethionine binding site [chemical binding]; other site 710686010155 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686010156 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686010157 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686010158 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686010159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686010160 active site 710686010161 catalytic tetrad [active] 710686010162 DoxX-like family; Region: DoxX_2; pfam13564 710686010163 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686010164 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686010165 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686010166 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710686010167 MarR family; Region: MarR_2; pfam12802 710686010168 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 710686010169 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710686010170 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710686010171 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710686010172 active site 710686010173 metal binding site [ion binding]; metal-binding site 710686010174 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 710686010175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686010176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686010177 D-xylulose kinase; Region: XylB; TIGR01312 710686010178 nucleotide binding site [chemical binding]; other site 710686010179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 710686010180 Predicted membrane protein [Function unknown]; Region: COG2259 710686010181 RDD family; Region: RDD; pfam06271 710686010182 GntP family permease; Region: GntP_permease; pfam02447 710686010183 fructuronate transporter; Provisional; Region: PRK10034; cl15264 710686010184 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 710686010185 AAA domain; Region: AAA_33; pfam13671 710686010186 ATP-binding site [chemical binding]; other site 710686010187 Gluconate-6-phosphate binding site [chemical binding]; other site 710686010188 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686010189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 710686010190 DNA-binding site [nucleotide binding]; DNA binding site 710686010191 FCD domain; Region: FCD; pfam07729 710686010192 hypothetical protein; Provisional; Region: PRK02237 710686010193 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710686010194 short chain dehydrogenase; Provisional; Region: PRK06197 710686010195 putative NAD(P) binding site [chemical binding]; other site 710686010196 active site 710686010197 Ecdysteroid kinase; Region: EcKinase; cl17738 710686010198 Phosphotransferase enzyme family; Region: APH; pfam01636 710686010199 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 710686010200 tyramine oxidase; Provisional; Region: tynA; PRK11504 710686010201 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 710686010202 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 710686010203 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 710686010204 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710686010205 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686010206 substrate binding pocket [chemical binding]; other site 710686010207 catalytic triad [active] 710686010208 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710686010209 Cation efflux family; Region: Cation_efflux; cl00316 710686010210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686010211 dimerization interface [polypeptide binding]; other site 710686010212 putative DNA binding site [nucleotide binding]; other site 710686010213 putative Zn2+ binding site [ion binding]; other site 710686010214 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 710686010215 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 710686010216 active site 710686010217 dimer interface [polypeptide binding]; other site 710686010218 non-prolyl cis peptide bond; other site 710686010219 insertion regions; other site 710686010220 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 710686010221 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 710686010222 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686010223 Ligand binding site; other site 710686010224 Putative Catalytic site; other site 710686010225 DXD motif; other site 710686010226 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 710686010227 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710686010228 putative active site [active] 710686010229 catalytic triad [active] 710686010230 putative dimer interface [polypeptide binding]; other site 710686010231 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686010232 Amidohydrolase family; Region: Amidohydro_3; pfam07969 710686010233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686010234 active site 710686010235 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 710686010236 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710686010237 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710686010238 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710686010239 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 710686010240 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710686010241 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710686010242 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710686010243 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 710686010244 precorrin-3B synthase; Region: CobG; TIGR02435 710686010245 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710686010246 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710686010247 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710686010248 CGNR zinc finger; Region: zf-CGNR; pfam11706 710686010249 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 710686010250 EamA-like transporter family; Region: EamA; pfam00892 710686010251 EamA-like transporter family; Region: EamA; pfam00892 710686010252 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 710686010253 Precorrin-8X methylmutase; Region: CbiC; pfam02570 710686010254 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 710686010255 SAM binding site [chemical binding]; other site 710686010256 active site 710686010257 homodimer interface [polypeptide binding]; other site 710686010258 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 710686010259 active site 710686010260 SAM binding site [chemical binding]; other site 710686010261 homodimer interface [polypeptide binding]; other site 710686010262 Phosphotransferase enzyme family; Region: APH; pfam01636 710686010263 Ecdysteroid kinase; Region: EcKinase; cl17738 710686010264 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 710686010265 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 710686010266 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 710686010267 active site 710686010268 SAM binding site [chemical binding]; other site 710686010269 homodimer interface [polypeptide binding]; other site 710686010270 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 710686010271 active site 710686010272 putative homodimer interface [polypeptide binding]; other site 710686010273 SAM binding site [chemical binding]; other site 710686010274 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 710686010275 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 710686010276 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686010277 classical (c) SDRs; Region: SDR_c; cd05233 710686010278 NAD(P) binding site [chemical binding]; other site 710686010279 active site 710686010280 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686010281 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686010282 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686010283 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 710686010284 active site 710686010285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 710686010286 dimer interface [polypeptide binding]; other site 710686010287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686010288 metal binding site [ion binding]; metal-binding site 710686010289 MarR family; Region: MarR; pfam01047 710686010290 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686010291 putative hydrophobic ligand binding site [chemical binding]; other site 710686010292 protein interface [polypeptide binding]; other site 710686010293 gate; other site 710686010294 5'-3' exonuclease; Region: 53EXOc; smart00475 710686010295 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710686010296 active site 710686010297 metal binding site 1 [ion binding]; metal-binding site 710686010298 putative 5' ssDNA interaction site; other site 710686010299 metal binding site 3; metal-binding site 710686010300 metal binding site 2 [ion binding]; metal-binding site 710686010301 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710686010302 putative DNA binding site [nucleotide binding]; other site 710686010303 putative metal binding site [ion binding]; other site 710686010304 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710686010305 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 710686010306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686010307 ATP binding site [chemical binding]; other site 710686010308 putative Mg++ binding site [ion binding]; other site 710686010309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686010310 nucleotide binding region [chemical binding]; other site 710686010311 ATP-binding site [chemical binding]; other site 710686010312 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 710686010313 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 710686010314 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 710686010315 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 710686010316 Predicted transcriptional regulator [Transcription]; Region: COG2378 710686010317 WYL domain; Region: WYL; pfam13280 710686010318 Predicted transcriptional regulator [Transcription]; Region: COG2378 710686010319 WYL domain; Region: WYL; pfam13280 710686010320 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 710686010321 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710686010322 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 710686010323 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 710686010324 putative active site [active] 710686010325 putative NTP binding site [chemical binding]; other site 710686010326 putative nucleic acid binding site [nucleotide binding]; other site 710686010327 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 710686010328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686010329 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 710686010330 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 710686010331 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 710686010332 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 710686010333 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710686010334 dimer interface [polypeptide binding]; other site 710686010335 active site 710686010336 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710686010337 folate binding site [chemical binding]; other site 710686010338 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686010339 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686010340 NAD(P) binding site [chemical binding]; other site 710686010341 catalytic residues [active] 710686010342 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 710686010343 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 710686010344 Walker A/P-loop; other site 710686010345 ATP binding site [chemical binding]; other site 710686010346 Q-loop/lid; other site 710686010347 ABC transporter signature motif; other site 710686010348 Walker B; other site 710686010349 D-loop; other site 710686010350 H-loop/switch region; other site 710686010351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686010352 dimer interface [polypeptide binding]; other site 710686010353 conserved gate region; other site 710686010354 putative PBP binding loops; other site 710686010355 ABC-ATPase subunit interface; other site 710686010356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686010357 dimer interface [polypeptide binding]; other site 710686010358 conserved gate region; other site 710686010359 ABC-ATPase subunit interface; other site 710686010360 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 710686010361 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710686010362 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 710686010363 [2Fe-2S] cluster binding site [ion binding]; other site 710686010364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710686010365 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 710686010366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686010367 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686010368 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686010369 [2Fe-2S] cluster binding site [ion binding]; other site 710686010370 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 710686010371 putative alpha subunit interface [polypeptide binding]; other site 710686010372 putative active site [active] 710686010373 putative substrate binding site [chemical binding]; other site 710686010374 Fe binding site [ion binding]; other site 710686010375 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686010376 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686010377 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686010378 choline dehydrogenase; Validated; Region: PRK02106 710686010379 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686010380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686010381 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710686010382 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710686010383 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710686010384 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686010385 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 710686010386 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686010387 NAD binding site [chemical binding]; other site 710686010388 catalytic Zn binding site [ion binding]; other site 710686010389 substrate binding site [chemical binding]; other site 710686010390 structural Zn binding site [ion binding]; other site 710686010391 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 710686010392 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 710686010393 putative active site [active] 710686010394 putative FMN binding site [chemical binding]; other site 710686010395 putative substrate binding site [chemical binding]; other site 710686010396 putative catalytic residue [active] 710686010397 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 710686010398 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 710686010399 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 710686010400 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 710686010401 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710686010402 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 710686010403 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 710686010404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686010405 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710686010406 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 710686010407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686010408 DNA-binding site [nucleotide binding]; DNA binding site 710686010409 FCD domain; Region: FCD; pfam07729 710686010410 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 710686010411 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 710686010412 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 710686010413 active site 710686010414 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 710686010415 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710686010416 active site 710686010417 Pup-like protein; Region: Pup; cl05289 710686010418 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 710686010419 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 710686010420 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 710686010421 proteasome ATPase; Region: pup_AAA; TIGR03689 710686010422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686010423 Walker A motif; other site 710686010424 ATP binding site [chemical binding]; other site 710686010425 Walker B motif; other site 710686010426 arginine finger; other site 710686010427 Protein of unknown function (DUF503); Region: DUF503; pfam04456 710686010428 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 710686010429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686010430 S-adenosylmethionine binding site [chemical binding]; other site 710686010431 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 710686010432 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710686010433 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686010434 active site 2 [active] 710686010435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686010436 dimerization interface [polypeptide binding]; other site 710686010437 putative DNA binding site [nucleotide binding]; other site 710686010438 putative Zn2+ binding site [ion binding]; other site 710686010439 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 710686010440 putative hydrophobic ligand binding site [chemical binding]; other site 710686010441 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710686010442 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686010443 mercuric reductase; Validated; Region: PRK06370 710686010444 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686010445 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686010446 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686010447 Predicted membrane protein [Function unknown]; Region: COG3918 710686010448 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 710686010449 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 710686010450 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 710686010451 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 710686010452 homodimer interface [polypeptide binding]; other site 710686010453 putative metal binding site [ion binding]; other site 710686010454 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 710686010455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686010456 putative substrate translocation pore; other site 710686010457 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710686010458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686010459 motif II; other site 710686010460 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 710686010461 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 710686010462 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 710686010463 substrate binding pocket [chemical binding]; other site 710686010464 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 710686010465 B12 binding site [chemical binding]; other site 710686010466 cobalt ligand [ion binding]; other site 710686010467 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 710686010468 PAC2 family; Region: PAC2; pfam09754 710686010469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710686010470 Bacterial transcriptional activator domain; Region: BTAD; smart01043 710686010471 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 710686010472 Zn binding site [ion binding]; other site 710686010473 Bacterial transcriptional activator domain; Region: BTAD; smart01043 710686010474 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710686010475 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710686010476 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710686010477 putative active site [active] 710686010478 catalytic site [active] 710686010479 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 710686010480 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710686010481 putative active site [active] 710686010482 catalytic site [active] 710686010483 Peptidase M15; Region: Peptidase_M15_3; cl01194 710686010484 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 710686010485 ligand binding site [chemical binding]; other site 710686010486 Peptidase M15; Region: Peptidase_M15_3; cl01194 710686010487 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 710686010488 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710686010489 Peptidase family M23; Region: Peptidase_M23; pfam01551 710686010490 Uncharacterized conserved protein [Function unknown]; Region: COG5361 710686010491 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 710686010492 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710686010493 short chain dehydrogenase; Provisional; Region: PRK05872 710686010494 classical (c) SDRs; Region: SDR_c; cd05233 710686010495 NAD(P) binding site [chemical binding]; other site 710686010496 active site 710686010497 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 710686010498 active site 710686010499 Mn binding site [ion binding]; other site 710686010500 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710686010501 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 710686010502 active site 710686010503 HIGH motif; other site 710686010504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686010505 active site 710686010506 KMSKS motif; other site 710686010507 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 710686010508 putative tRNA binding surface [nucleotide binding]; other site 710686010509 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710686010510 active site 710686010511 conserved hypothetical protein; Region: TIGR03843 710686010512 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 710686010513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686010514 catalytic core [active] 710686010515 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 710686010516 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686010517 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 710686010518 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 710686010519 quinone interaction residues [chemical binding]; other site 710686010520 active site 710686010521 catalytic residues [active] 710686010522 FMN binding site [chemical binding]; other site 710686010523 substrate binding site [chemical binding]; other site 710686010524 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710686010525 substrate binding site [chemical binding]; other site 710686010526 hypothetical protein; Provisional; Region: PRK07906 710686010527 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 710686010528 putative metal binding site [ion binding]; other site 710686010529 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686010530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686010531 NAD(P) binding site [chemical binding]; other site 710686010532 active site 710686010533 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 710686010534 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 710686010535 [4Fe-4S] binding site [ion binding]; other site 710686010536 molybdopterin cofactor binding site; other site 710686010537 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 710686010538 molybdopterin cofactor binding site; other site 710686010539 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 710686010540 Flavodoxin; Region: Flavodoxin_1; pfam00258 710686010541 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 710686010542 FAD binding pocket [chemical binding]; other site 710686010543 FAD binding motif [chemical binding]; other site 710686010544 catalytic residues [active] 710686010545 NAD binding pocket [chemical binding]; other site 710686010546 phosphate binding motif [ion binding]; other site 710686010547 beta-alpha-beta structure motif; other site 710686010548 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 710686010549 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686010550 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686010551 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710686010552 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710686010553 Walker A/P-loop; other site 710686010554 ATP binding site [chemical binding]; other site 710686010555 Q-loop/lid; other site 710686010556 ABC transporter signature motif; other site 710686010557 Walker B; other site 710686010558 D-loop; other site 710686010559 H-loop/switch region; other site 710686010560 TOBE domain; Region: TOBE_2; pfam08402 710686010561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710686010562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686010563 dimer interface [polypeptide binding]; other site 710686010564 conserved gate region; other site 710686010565 putative PBP binding loops; other site 710686010566 ABC-ATPase subunit interface; other site 710686010567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686010568 dimer interface [polypeptide binding]; other site 710686010569 conserved gate region; other site 710686010570 putative PBP binding loops; other site 710686010571 ABC-ATPase subunit interface; other site 710686010572 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710686010573 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710686010574 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710686010575 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686010576 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686010577 NAD(P) binding site [chemical binding]; other site 710686010578 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710686010579 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 710686010580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686010581 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686010582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710686010583 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 710686010584 active site 1 [active] 710686010585 dimer interface [polypeptide binding]; other site 710686010586 hexamer interface [polypeptide binding]; other site 710686010587 active site 2 [active] 710686010588 AAA ATPase domain; Region: AAA_16; pfam13191 710686010589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686010590 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686010591 DNA binding residues [nucleotide binding] 710686010592 dimerization interface [polypeptide binding]; other site 710686010593 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710686010594 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 710686010595 putative active site [active] 710686010596 catalytic site [active] 710686010597 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 710686010598 putative active site [active] 710686010599 catalytic site [active] 710686010600 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710686010601 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710686010602 putative active site [active] 710686010603 catalytic site [active] 710686010604 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 710686010605 putative active site [active] 710686010606 catalytic site [active] 710686010607 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686010608 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686010609 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 710686010610 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710686010611 catalytic triad [active] 710686010612 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 710686010613 putative hydrophobic ligand binding site [chemical binding]; other site 710686010614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686010615 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 710686010616 NAD(P) binding site [chemical binding]; other site 710686010617 active site 710686010618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686010619 active site 710686010620 DivIVA domain; Region: DivI1A_domain; TIGR03544 710686010621 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710686010622 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 710686010623 Predicted integral membrane protein [Function unknown]; Region: COG0762 710686010624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 710686010625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710686010626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686010627 catalytic residue [active] 710686010628 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 710686010629 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 710686010630 cell division protein FtsZ; Validated; Region: PRK09330 710686010631 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 710686010632 nucleotide binding site [chemical binding]; other site 710686010633 SulA interaction site; other site 710686010634 cell division protein FtsQ; Provisional; Region: PRK05529 710686010635 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 710686010636 Cell division protein FtsQ; Region: FtsQ; pfam03799 710686010637 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 710686010638 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710686010639 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686010640 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710686010641 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 710686010642 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 710686010643 active site 710686010644 homodimer interface [polypeptide binding]; other site 710686010645 cell division protein FtsW; Region: ftsW; TIGR02614 710686010646 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 710686010647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686010648 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 710686010649 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 710686010650 Mg++ binding site [ion binding]; other site 710686010651 putative catalytic motif [active] 710686010652 putative substrate binding site [chemical binding]; other site 710686010653 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 710686010654 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710686010655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686010656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710686010657 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 710686010658 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686010659 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710686010660 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710686010661 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 710686010662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710686010663 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 710686010664 MraW methylase family; Region: Methyltransf_5; pfam01795 710686010665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 710686010666 MraZ protein; Region: MraZ; pfam02381 710686010667 MraZ protein; Region: MraZ; pfam02381 710686010668 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 710686010669 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 710686010670 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710686010671 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710686010672 substrate binding pocket [chemical binding]; other site 710686010673 chain length determination region; other site 710686010674 substrate-Mg2+ binding site; other site 710686010675 catalytic residues [active] 710686010676 aspartate-rich region 1; other site 710686010677 active site lid residues [active] 710686010678 aspartate-rich region 2; other site 710686010679 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710686010680 HSP90 family protein; Provisional; Region: PRK14083 710686010681 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686010682 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686010683 active site 710686010684 ATP binding site [chemical binding]; other site 710686010685 substrate binding site [chemical binding]; other site 710686010686 activation loop (A-loop); other site 710686010687 hypothetical protein; Provisional; Region: PRK06184 710686010688 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686010689 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 710686010690 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710686010691 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686010692 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686010693 putative acyl-acceptor binding pocket; other site 710686010694 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710686010695 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710686010696 P loop; other site 710686010697 Nucleotide binding site [chemical binding]; other site 710686010698 DTAP/Switch II; other site 710686010699 Switch I; other site 710686010700 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710686010701 putative hydrophobic ligand binding site [chemical binding]; other site 710686010702 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 710686010703 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710686010704 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710686010705 acyl-activating enzyme (AAE) consensus motif; other site 710686010706 putative AMP binding site [chemical binding]; other site 710686010707 putative active site [active] 710686010708 putative CoA binding site [chemical binding]; other site 710686010709 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686010710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686010711 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 710686010712 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710686010713 NlpC/P60 family; Region: NLPC_P60; pfam00877 710686010714 hypothetical protein; Validated; Region: PRK07883 710686010715 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710686010716 active site 710686010717 catalytic site [active] 710686010718 substrate binding site [chemical binding]; other site 710686010719 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710686010720 GIY-YIG motif/motif A; other site 710686010721 active site 710686010722 catalytic site [active] 710686010723 putative DNA binding site [nucleotide binding]; other site 710686010724 metal binding site [ion binding]; metal-binding site 710686010725 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 710686010726 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710686010727 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710686010728 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 710686010729 Subunit I/III interface [polypeptide binding]; other site 710686010730 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710686010731 Cytochrome c; Region: Cytochrom_C; pfam00034 710686010732 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710686010733 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 710686010734 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 710686010735 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710686010736 iron-sulfur cluster [ion binding]; other site 710686010737 [2Fe-2S] cluster binding site [ion binding]; other site 710686010738 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 710686010739 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 710686010740 heme bH binding site [chemical binding]; other site 710686010741 intrachain domain interface; other site 710686010742 heme bL binding site [chemical binding]; other site 710686010743 interchain domain interface [polypeptide binding]; other site 710686010744 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 710686010745 Qo binding site; other site 710686010746 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 710686010747 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 710686010748 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686010749 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 710686010750 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 710686010751 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 710686010752 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 710686010753 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710686010754 active site 710686010755 dimer interface [polypeptide binding]; other site 710686010756 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710686010757 Ligand Binding Site [chemical binding]; other site 710686010758 Molecular Tunnel; other site 710686010759 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 710686010760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710686010761 substrate binding site [chemical binding]; other site 710686010762 ATP binding site [chemical binding]; other site 710686010763 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 710686010764 Glycerate kinase family; Region: Gly_kinase; cl00841 710686010765 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 710686010766 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 710686010767 homotrimer interface [polypeptide binding]; other site 710686010768 Walker A motif; other site 710686010769 GTP binding site [chemical binding]; other site 710686010770 Walker B motif; other site 710686010771 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 710686010772 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 710686010773 putative dimer interface [polypeptide binding]; other site 710686010774 active site pocket [active] 710686010775 putative cataytic base [active] 710686010776 cobalamin synthase; Reviewed; Region: cobS; PRK00235 710686010777 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 710686010778 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 710686010779 homodimer interface [polypeptide binding]; other site 710686010780 substrate-cofactor binding pocket; other site 710686010781 catalytic residue [active] 710686010782 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 710686010783 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710686010784 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686010785 cyclase homology domain; Region: CHD; cd07302 710686010786 nucleotidyl binding site; other site 710686010787 metal binding site [ion binding]; metal-binding site 710686010788 dimer interface [polypeptide binding]; other site 710686010789 multifunctional aminopeptidase A; Provisional; Region: PRK00913 710686010790 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 710686010791 interface (dimer of trimers) [polypeptide binding]; other site 710686010792 Substrate-binding/catalytic site; other site 710686010793 Zn-binding sites [ion binding]; other site 710686010794 short chain dehydrogenase; Validated; Region: PRK05855 710686010795 classical (c) SDRs; Region: SDR_c; cd05233 710686010796 NAD(P) binding site [chemical binding]; other site 710686010797 active site 710686010798 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686010799 E3 interaction surface; other site 710686010800 lipoyl attachment site [posttranslational modification]; other site 710686010801 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686010802 E3 interaction surface; other site 710686010803 lipoyl attachment site [posttranslational modification]; other site 710686010804 e3 binding domain; Region: E3_binding; pfam02817 710686010805 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 710686010806 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710686010807 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 710686010808 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 710686010809 putative NAD(P) binding site [chemical binding]; other site 710686010810 putative active site [active] 710686010811 lipoate-protein ligase B; Provisional; Region: PRK14345 710686010812 lipoyl synthase; Provisional; Region: PRK05481 710686010813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686010814 FeS/SAM binding site; other site 710686010815 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 710686010816 RDD family; Region: RDD; pfam06271 710686010817 glutamine synthetase, type I; Region: GlnA; TIGR00653 710686010818 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710686010819 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686010820 Predicted membrane protein [Function unknown]; Region: COG2259 710686010821 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686010822 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686010823 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686010824 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686010825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686010826 CoenzymeA binding site [chemical binding]; other site 710686010827 subunit interaction site [polypeptide binding]; other site 710686010828 PHB binding site; other site 710686010829 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 710686010830 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710686010831 metal binding triad; other site 710686010832 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710686010833 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710686010834 metal binding triad; other site 710686010835 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710686010836 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710686010837 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710686010838 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686010839 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710686010840 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686010841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710686010842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686010843 Coenzyme A binding pocket [chemical binding]; other site 710686010844 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710686010845 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686010846 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686010847 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686010848 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710686010849 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 710686010850 oligomerization interface [polypeptide binding]; other site 710686010851 active site 710686010852 metal binding site [ion binding]; metal-binding site 710686010853 enoyl-CoA hydratase; Provisional; Region: PRK08140 710686010854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686010855 substrate binding site [chemical binding]; other site 710686010856 oxyanion hole (OAH) forming residues; other site 710686010857 trimer interface [polypeptide binding]; other site 710686010858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686010859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686010860 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 710686010861 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 710686010862 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 710686010863 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 710686010864 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 710686010865 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 710686010866 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 710686010867 putative active site; other site 710686010868 putative metal binding residues [ion binding]; other site 710686010869 signature motif; other site 710686010870 putative triphosphate binding site [ion binding]; other site 710686010871 CHAD domain; Region: CHAD; pfam05235 710686010872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686010873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686010874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686010875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686010876 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710686010877 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710686010878 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686010879 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686010880 active site 710686010881 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 710686010882 Part of AAA domain; Region: AAA_19; pfam13245 710686010883 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 710686010884 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710686010885 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710686010886 DNA binding site [nucleotide binding] 710686010887 active site 710686010888 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 710686010889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686010890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686010891 S-adenosylmethionine binding site [chemical binding]; other site 710686010892 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710686010893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686010894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686010895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686010896 sequence-specific DNA binding site [nucleotide binding]; other site 710686010897 salt bridge; other site 710686010898 Cupin domain; Region: Cupin_2; pfam07883 710686010899 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 710686010900 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686010901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686010902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686010903 active site 710686010904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686010905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686010906 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 710686010907 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 710686010908 RNA/DNA hybrid binding site [nucleotide binding]; other site 710686010909 active site 710686010910 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686010911 catalytic core [active] 710686010912 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 710686010913 Putative zinc ribbon domain; Region: DUF164; pfam02591 710686010914 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 710686010915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 710686010916 Uncharacterized conserved protein [Function unknown]; Region: COG0327 710686010917 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710686010918 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 710686010919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686010920 motif II; other site 710686010921 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710686010922 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710686010923 active site 710686010924 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 710686010925 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 710686010926 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686010927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686010928 active site 710686010929 metal binding site [ion binding]; metal-binding site 710686010930 Cutinase; Region: Cutinase; pfam01083 710686010931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686010932 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 710686010933 NADP binding site [chemical binding]; other site 710686010934 dimer interface [polypeptide binding]; other site 710686010935 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686010936 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 710686010937 NADP binding site [chemical binding]; other site 710686010938 dimer interface [polypeptide binding]; other site 710686010939 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710686010940 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 710686010941 dimer interface [polypeptide binding]; other site 710686010942 catalytic triad [active] 710686010943 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 710686010944 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 710686010945 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 710686010946 dimer interface [polypeptide binding]; other site 710686010947 TPP-binding site [chemical binding]; other site 710686010948 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710686010949 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686010950 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710686010951 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686010952 acyl carrier protein; Provisional; Region: acpP; PRK00982 710686010953 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710686010954 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710686010955 dimer interface [polypeptide binding]; other site 710686010956 active site 710686010957 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710686010958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710686010959 dimer interface [polypeptide binding]; other site 710686010960 active site 710686010961 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710686010962 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686010963 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686010964 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686010965 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686010966 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 710686010967 diiron binding motif [ion binding]; other site 710686010968 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 710686010969 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710686010970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686010971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686010972 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686010973 FAD binding domain; Region: FAD_binding_4; pfam01565 710686010974 diacylglycerol kinase; Reviewed; Region: PRK11914 710686010975 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710686010976 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 710686010977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686010978 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686010979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686010980 S-adenosylmethionine binding site [chemical binding]; other site 710686010981 ubiquinone biosynthesis methyltransferase; Region: PLN02232 710686010982 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 710686010983 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710686010984 putative active site [active] 710686010985 metal binding site [ion binding]; metal-binding site 710686010986 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 710686010987 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686010988 NAD binding site [chemical binding]; other site 710686010989 catalytic Zn binding site [ion binding]; other site 710686010990 substrate binding site [chemical binding]; other site 710686010991 structural Zn binding site [ion binding]; other site 710686010992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686010993 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710686010994 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710686010995 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710686010996 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710686010997 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710686010998 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710686010999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 710686011000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 710686011001 Short C-terminal domain; Region: SHOCT; pfam09851 710686011002 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 710686011003 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710686011004 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686011005 conserved cys residue [active] 710686011006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686011007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686011008 hypothetical protein; Validated; Region: PRK07586 710686011009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686011010 PYR/PP interface [polypeptide binding]; other site 710686011011 dimer interface [polypeptide binding]; other site 710686011012 TPP binding site [chemical binding]; other site 710686011013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686011014 DNA binding residues [nucleotide binding] 710686011015 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 710686011016 TPP-binding site [chemical binding]; other site 710686011017 dimer interface [polypeptide binding]; other site 710686011018 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 710686011019 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710686011020 conserved cys residue [active] 710686011021 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686011022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686011023 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686011024 nucleotide binding site [chemical binding]; other site 710686011025 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686011026 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686011027 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686011028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686011029 NAD(P) binding site [chemical binding]; other site 710686011030 active site 710686011031 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 710686011032 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710686011033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710686011034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011035 dimer interface [polypeptide binding]; other site 710686011036 conserved gate region; other site 710686011037 putative PBP binding loops; other site 710686011038 ABC-ATPase subunit interface; other site 710686011039 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 710686011040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011041 dimer interface [polypeptide binding]; other site 710686011042 conserved gate region; other site 710686011043 putative PBP binding loops; other site 710686011044 ABC-ATPase subunit interface; other site 710686011045 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710686011046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686011047 Walker A/P-loop; other site 710686011048 ATP binding site [chemical binding]; other site 710686011049 Q-loop/lid; other site 710686011050 ABC transporter signature motif; other site 710686011051 Walker B; other site 710686011052 D-loop; other site 710686011053 H-loop/switch region; other site 710686011054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686011055 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686011056 Walker A/P-loop; other site 710686011057 ATP binding site [chemical binding]; other site 710686011058 Q-loop/lid; other site 710686011059 ABC transporter signature motif; other site 710686011060 Walker B; other site 710686011061 D-loop; other site 710686011062 H-loop/switch region; other site 710686011063 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 710686011064 classical (c) SDRs; Region: SDR_c; cd05233 710686011065 NAD(P) binding site [chemical binding]; other site 710686011066 active site 710686011067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686011068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686011069 active site 710686011070 catalytic tetrad [active] 710686011071 Short C-terminal domain; Region: SHOCT; pfam09851 710686011072 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 710686011073 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686011074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686011075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686011076 active site 710686011077 ATP binding site [chemical binding]; other site 710686011078 substrate binding site [chemical binding]; other site 710686011079 activation loop (A-loop); other site 710686011080 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686011081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686011082 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686011083 Response regulator receiver domain; Region: Response_reg; pfam00072 710686011084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710686011085 DNA binding residues [nucleotide binding] 710686011086 dimerization interface [polypeptide binding]; other site 710686011087 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 710686011088 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686011089 putative active site [active] 710686011090 putative metal binding site [ion binding]; other site 710686011091 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 710686011092 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686011093 putative active site [active] 710686011094 putative metal binding site [ion binding]; other site 710686011095 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710686011096 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 710686011097 DXD motif; other site 710686011098 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 710686011099 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710686011100 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710686011101 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710686011102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710686011103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710686011104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710686011105 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710686011106 Sulfatase; Region: Sulfatase; pfam00884 710686011107 TrwC relaxase; Region: TrwC; pfam08751 710686011108 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710686011109 AAA domain; Region: AAA_30; pfam13604 710686011110 Family description; Region: UvrD_C_2; pfam13538 710686011111 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 710686011112 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686011113 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686011114 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686011115 cyclase homology domain; Region: CHD; cd07302 710686011116 nucleotidyl binding site; other site 710686011117 metal binding site [ion binding]; metal-binding site 710686011118 dimer interface [polypeptide binding]; other site 710686011119 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686011120 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686011121 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710686011122 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710686011123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011124 putative PBP binding loops; other site 710686011125 ABC-ATPase subunit interface; other site 710686011126 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710686011127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011128 dimer interface [polypeptide binding]; other site 710686011129 conserved gate region; other site 710686011130 putative PBP binding loops; other site 710686011131 ABC-ATPase subunit interface; other site 710686011132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710686011133 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710686011134 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710686011135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710686011136 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 710686011137 Walker A/P-loop; other site 710686011138 ATP binding site [chemical binding]; other site 710686011139 Q-loop/lid; other site 710686011140 ABC transporter signature motif; other site 710686011141 Walker B; other site 710686011142 D-loop; other site 710686011143 H-loop/switch region; other site 710686011144 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710686011145 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710686011146 Walker A/P-loop; other site 710686011147 ATP binding site [chemical binding]; other site 710686011148 Q-loop/lid; other site 710686011149 ABC transporter signature motif; other site 710686011150 Walker B; other site 710686011151 D-loop; other site 710686011152 H-loop/switch region; other site 710686011153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686011154 MarR family; Region: MarR; pfam01047 710686011155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686011156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686011157 putative substrate translocation pore; other site 710686011158 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 710686011159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686011160 active site 710686011161 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 710686011162 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 710686011163 DNA primase; Validated; Region: dnaG; PRK05667 710686011164 CHC2 zinc finger; Region: zf-CHC2; cl17510 710686011165 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710686011166 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710686011167 active site 710686011168 metal binding site [ion binding]; metal-binding site 710686011169 interdomain interaction site; other site 710686011170 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 710686011171 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 710686011172 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 710686011173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686011174 Zn2+ binding site [ion binding]; other site 710686011175 Mg2+ binding site [ion binding]; other site 710686011176 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 710686011177 Repair protein; Region: Repair_PSII; pfam04536 710686011178 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710686011179 putative active site [active] 710686011180 putative CoA binding site [chemical binding]; other site 710686011181 nudix motif; other site 710686011182 metal binding site [ion binding]; metal-binding site 710686011183 glycyl-tRNA synthetase; Provisional; Region: PRK04173 710686011184 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710686011185 motif 1; other site 710686011186 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 710686011187 active site 710686011188 motif 2; other site 710686011189 motif 3; other site 710686011190 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 710686011191 anticodon binding site; other site 710686011192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686011193 dimerization interface [polypeptide binding]; other site 710686011194 putative DNA binding site [nucleotide binding]; other site 710686011195 putative Zn2+ binding site [ion binding]; other site 710686011196 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710686011197 metal binding site 2 [ion binding]; metal-binding site 710686011198 putative DNA binding helix; other site 710686011199 metal binding site 1 [ion binding]; metal-binding site 710686011200 dimer interface [polypeptide binding]; other site 710686011201 structural Zn2+ binding site [ion binding]; other site 710686011202 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 710686011203 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 710686011204 catalytic residue [active] 710686011205 putative FPP diphosphate binding site; other site 710686011206 putative FPP binding hydrophobic cleft; other site 710686011207 dimer interface [polypeptide binding]; other site 710686011208 putative IPP diphosphate binding site; other site 710686011209 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 710686011210 Recombination protein O N terminal; Region: RecO_N; pfam11967 710686011211 Recombination protein O C terminal; Region: RecO_C; pfam02565 710686011212 amidase; Provisional; Region: PRK06061 710686011213 Amidase; Region: Amidase; pfam01425 710686011214 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686011215 GTPase Era; Reviewed; Region: era; PRK00089 710686011216 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 710686011217 G1 box; other site 710686011218 GTP/Mg2+ binding site [chemical binding]; other site 710686011219 Switch I region; other site 710686011220 G2 box; other site 710686011221 Switch II region; other site 710686011222 G3 box; other site 710686011223 G4 box; other site 710686011224 G5 box; other site 710686011225 KH domain; Region: KH_2; pfam07650 710686011226 Domain of unknown function DUF21; Region: DUF21; pfam01595 710686011227 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710686011228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710686011229 Transporter associated domain; Region: CorC_HlyC; smart01091 710686011230 metal-binding heat shock protein; Provisional; Region: PRK00016 710686011231 K homology RNA-binding domain; Region: KH; smart00322 710686011232 PhoH-like protein; Region: PhoH; pfam02562 710686011233 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 710686011234 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 710686011235 thioester formation/cholesterol transfer; other site 710686011236 PhoH-like protein; Region: PhoH; pfam02562 710686011237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 710686011238 chaperone protein DnaJ; Provisional; Region: PRK14278 710686011239 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710686011240 HSP70 interaction site [polypeptide binding]; other site 710686011241 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710686011242 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710686011243 dimer interface [polypeptide binding]; other site 710686011244 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710686011245 HTH domain; Region: HTH_11; cl17392 710686011246 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 710686011247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686011248 ATP binding site [chemical binding]; other site 710686011249 putative Mg++ binding site [ion binding]; other site 710686011250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686011251 nucleotide binding region [chemical binding]; other site 710686011252 ATP-binding site [chemical binding]; other site 710686011253 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 710686011254 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 710686011255 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710686011256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686011257 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686011258 DNA binding residues [nucleotide binding] 710686011259 coproporphyrinogen III oxidase; Validated; Region: PRK05628 710686011260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686011261 FeS/SAM binding site; other site 710686011262 HemN C-terminal domain; Region: HemN_C; pfam06969 710686011263 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 710686011264 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710686011265 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710686011266 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 710686011267 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710686011268 Active Sites [active] 710686011269 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710686011270 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710686011271 putative active site [active] 710686011272 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710686011273 putative active site [active] 710686011274 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686011275 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 710686011276 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 710686011277 Walker A/P-loop; other site 710686011278 ATP binding site [chemical binding]; other site 710686011279 Q-loop/lid; other site 710686011280 ABC transporter signature motif; other site 710686011281 Walker B; other site 710686011282 D-loop; other site 710686011283 H-loop/switch region; other site 710686011284 TOBE domain; Region: TOBE; pfam03459 710686011285 sulfate transport protein; Provisional; Region: cysT; CHL00187 710686011286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011287 dimer interface [polypeptide binding]; other site 710686011288 conserved gate region; other site 710686011289 putative PBP binding loops; other site 710686011290 ABC-ATPase subunit interface; other site 710686011291 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710686011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686011293 dimer interface [polypeptide binding]; other site 710686011294 conserved gate region; other site 710686011295 putative PBP binding loops; other site 710686011296 ABC-ATPase subunit interface; other site 710686011297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710686011298 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710686011299 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710686011300 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710686011301 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686011302 Domain of unknown function (DUF202); Region: DUF202; cl09954 710686011303 Domain of unknown function (DUF202); Region: DUF202; pfam02656 710686011304 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686011305 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686011306 GTP-binding protein LepA; Provisional; Region: PRK05433 710686011307 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 710686011308 G1 box; other site 710686011309 putative GEF interaction site [polypeptide binding]; other site 710686011310 GTP/Mg2+ binding site [chemical binding]; other site 710686011311 Switch I region; other site 710686011312 G2 box; other site 710686011313 G3 box; other site 710686011314 Switch II region; other site 710686011315 G4 box; other site 710686011316 G5 box; other site 710686011317 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710686011318 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710686011319 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710686011320 PemK-like protein; Region: PemK; pfam02452 710686011321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710686011322 Coenzyme A binding pocket [chemical binding]; other site 710686011323 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 710686011324 FOG: CBS domain [General function prediction only]; Region: COG0517 710686011325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686011326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686011327 active site 710686011328 catalytic tetrad [active] 710686011329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686011330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686011331 Creatinine amidohydrolase; Region: Creatininase; pfam02633 710686011332 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 710686011333 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686011334 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686011335 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686011336 [2Fe-2S] cluster binding site [ion binding]; other site 710686011337 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686011338 hydrophobic ligand binding site; other site 710686011339 ribonuclease Z; Reviewed; Region: PRK00055 710686011340 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686011341 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686011342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686011343 MarR family; Region: MarR_2; pfam12802 710686011344 MarR family; Region: MarR_2; cl17246 710686011345 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710686011346 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710686011347 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710686011348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710686011349 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710686011350 Uncharacterized conserved protein [Function unknown]; Region: COG2308 710686011351 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 710686011352 hypothetical protein; Reviewed; Region: PRK07914 710686011353 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 710686011354 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 710686011355 Competence protein; Region: Competence; pfam03772 710686011356 Helix-hairpin-helix motif; Region: HHH; pfam00633 710686011357 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 710686011358 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686011359 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686011360 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710686011361 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 710686011362 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710686011363 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 710686011364 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710686011365 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710686011366 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 710686011367 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710686011368 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710686011369 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 710686011370 homotrimer interaction site [polypeptide binding]; other site 710686011371 putative active site [active] 710686011372 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 710686011373 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710686011374 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686011375 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686011376 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686011377 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686011378 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686011379 classical (c) SDRs; Region: SDR_c; cd05233 710686011380 NAD(P) binding site [chemical binding]; other site 710686011381 active site 710686011382 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686011383 classical (c) SDRs; Region: SDR_c; cd05233 710686011384 NAD(P) binding site [chemical binding]; other site 710686011385 active site 710686011386 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686011387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686011388 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686011389 catalytic loop [active] 710686011390 iron binding site [ion binding]; other site 710686011391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686011392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686011393 active site 710686011394 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710686011395 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710686011396 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710686011397 active site 710686011398 Fe binding site [ion binding]; other site 710686011399 hypothetical protein; Validated; Region: PRK07121 710686011400 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686011401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686011402 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686011403 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686011404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686011405 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686011406 substrate binding pocket [chemical binding]; other site 710686011407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686011408 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 710686011409 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 710686011410 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686011411 NAD(P) binding site [chemical binding]; other site 710686011412 homodimer interface [polypeptide binding]; other site 710686011413 active site 710686011414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686011415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686011416 active site 710686011417 acyl-CoA synthetase; Validated; Region: PRK08316 710686011418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686011419 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686011420 acyl-activating enzyme (AAE) consensus motif; other site 710686011421 putative AMP binding site [chemical binding]; other site 710686011422 putative active site [active] 710686011423 putative CoA binding site [chemical binding]; other site 710686011424 classical (c) SDRs; Region: SDR_c; cd05233 710686011425 NAD(P) binding site [chemical binding]; other site 710686011426 active site 710686011427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686011428 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686011429 short chain dehydrogenase; Provisional; Region: PRK08303 710686011430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686011431 NAD(P) binding site [chemical binding]; other site 710686011432 active site 710686011433 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686011434 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710686011435 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686011436 hydrophobic ligand binding site; other site 710686011437 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 710686011438 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686011439 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686011440 Transcriptional regulator PadR-like family; Region: PadR; cl17335 710686011441 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686011442 CoenzymeA binding site [chemical binding]; other site 710686011443 subunit interaction site [polypeptide binding]; other site 710686011444 PHB binding site; other site 710686011445 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 710686011446 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686011447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686011448 classical (c) SDRs; Region: SDR_c; cd05233 710686011449 NAD(P) binding site [chemical binding]; other site 710686011450 active site 710686011451 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686011452 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686011453 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686011454 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686011455 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 710686011456 putative hydrophobic ligand binding site [chemical binding]; other site 710686011457 CLM binding site; other site 710686011458 L1 loop; other site 710686011459 DNA binding site [nucleotide binding] 710686011460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686011461 putative DNA binding site [nucleotide binding]; other site 710686011462 putative Zn2+ binding site [ion binding]; other site 710686011463 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686011464 anti sigma factor interaction site; other site 710686011465 regulatory phosphorylation site [posttranslational modification]; other site 710686011466 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686011467 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710686011468 GAF domain; Region: GAF_3; pfam13492 710686011469 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710686011470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710686011471 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710686011472 EDD domain protein, DegV family; Region: DegV; TIGR00762 710686011473 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710686011474 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686011475 active site 710686011476 catalytic triad [active] 710686011477 oxyanion hole [active] 710686011478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686011479 catalytic core [active] 710686011480 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 710686011481 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710686011482 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 710686011483 active site 710686011484 (T/H)XGH motif; other site 710686011485 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710686011486 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686011487 metal ion-dependent adhesion site (MIDAS); other site 710686011488 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710686011489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686011490 Walker A motif; other site 710686011491 ATP binding site [chemical binding]; other site 710686011492 Walker B motif; other site 710686011493 arginine finger; other site 710686011494 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 710686011495 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 710686011496 putative catalytic cysteine [active] 710686011497 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710686011498 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710686011499 substrate binding site [chemical binding]; other site 710686011500 ATP binding site [chemical binding]; other site 710686011501 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686011502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686011503 substrate binding site [chemical binding]; other site 710686011504 oxyanion hole (OAH) forming residues; other site 710686011505 trimer interface [polypeptide binding]; other site 710686011506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686011507 putative DNA binding site [nucleotide binding]; other site 710686011508 putative Zn2+ binding site [ion binding]; other site 710686011509 Cation efflux family; Region: Cation_efflux; cl00316 710686011510 NAD synthetase; Reviewed; Region: nadE; PRK02628 710686011511 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 710686011512 multimer interface [polypeptide binding]; other site 710686011513 active site 710686011514 catalytic triad [active] 710686011515 protein interface 1 [polypeptide binding]; other site 710686011516 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 710686011517 homodimer interface [polypeptide binding]; other site 710686011518 NAD binding pocket [chemical binding]; other site 710686011519 ATP binding pocket [chemical binding]; other site 710686011520 Mg binding site [ion binding]; other site 710686011521 active-site loop [active] 710686011522 Isochorismatase family; Region: Isochorismatase; pfam00857 710686011523 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710686011524 catalytic triad [active] 710686011525 conserved cis-peptide bond; other site 710686011526 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710686011527 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710686011528 putative dimer interface [polypeptide binding]; other site 710686011529 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 710686011530 NAD-dependent deacetylase; Provisional; Region: PRK05333 710686011531 NAD+ binding site [chemical binding]; other site 710686011532 substrate binding site [chemical binding]; other site 710686011533 Zn binding site [ion binding]; other site 710686011534 gamma-glutamyl kinase; Provisional; Region: PRK05429 710686011535 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 710686011536 nucleotide binding site [chemical binding]; other site 710686011537 homotetrameric interface [polypeptide binding]; other site 710686011538 putative phosphate binding site [ion binding]; other site 710686011539 putative allosteric binding site; other site 710686011540 PUA domain; Region: PUA; pfam01472 710686011541 GTPase CgtA; Reviewed; Region: obgE; PRK12296 710686011542 GTP1/OBG; Region: GTP1_OBG; pfam01018 710686011543 Obg GTPase; Region: Obg; cd01898 710686011544 G1 box; other site 710686011545 GTP/Mg2+ binding site [chemical binding]; other site 710686011546 Switch I region; other site 710686011547 G2 box; other site 710686011548 G3 box; other site 710686011549 Switch II region; other site 710686011550 G4 box; other site 710686011551 G5 box; other site 710686011552 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 710686011553 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 710686011554 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 710686011555 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 710686011556 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 710686011557 homodimer interface [polypeptide binding]; other site 710686011558 oligonucleotide binding site [chemical binding]; other site 710686011559 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 710686011560 active site 710686011561 multimer interface [polypeptide binding]; other site 710686011562 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 710686011563 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 710686011564 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686011565 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710686011566 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 710686011567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686011568 active site 710686011569 HIGH motif; other site 710686011570 nucleotide binding site [chemical binding]; other site 710686011571 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710686011572 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 710686011573 active site 710686011574 KMSKS motif; other site 710686011575 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710686011576 tRNA binding surface [nucleotide binding]; other site 710686011577 anticodon binding site; other site 710686011578 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 710686011579 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 710686011580 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710686011581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686011582 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710686011583 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686011584 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686011585 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686011586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686011587 CoenzymeA binding site [chemical binding]; other site 710686011588 subunit interaction site [polypeptide binding]; other site 710686011589 PHB binding site; other site 710686011590 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686011591 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710686011592 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710686011593 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 710686011594 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 710686011595 GTP binding site; other site 710686011596 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 710686011597 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 710686011598 TPP-binding site [chemical binding]; other site 710686011599 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710686011600 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 710686011601 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710686011602 dimer interface [polypeptide binding]; other site 710686011603 PYR/PP interface [polypeptide binding]; other site 710686011604 TPP binding site [chemical binding]; other site 710686011605 substrate binding site [chemical binding]; other site 710686011606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710686011607 DNA binding site [nucleotide binding] 710686011608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 710686011609 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 710686011610 putative ligand binding site [chemical binding]; other site 710686011611 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 710686011612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686011613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686011614 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710686011615 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710686011616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686011617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686011618 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710686011619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686011620 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686011621 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710686011622 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 710686011623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686011624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686011625 DNA binding residues [nucleotide binding] 710686011626 dimerization interface [polypeptide binding]; other site 710686011627 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686011628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686011629 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 710686011630 Walker A/P-loop; other site 710686011631 ATP binding site [chemical binding]; other site 710686011632 Q-loop/lid; other site 710686011633 ABC transporter signature motif; other site 710686011634 Walker B; other site 710686011635 D-loop; other site 710686011636 H-loop/switch region; other site 710686011637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710686011638 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710686011639 TM-ABC transporter signature motif; other site 710686011640 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 710686011641 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 710686011642 putative ligand binding site [chemical binding]; other site 710686011643 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 710686011644 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710686011645 DNA interaction; other site 710686011646 Metal-binding active site; metal-binding site 710686011647 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686011648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686011649 DNA-binding site [nucleotide binding]; DNA binding site 710686011650 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710686011651 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710686011652 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 710686011653 substrate binding site [chemical binding]; other site 710686011654 ATP binding site [chemical binding]; other site 710686011655 KduI/IolB family; Region: KduI; pfam04962 710686011656 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 710686011657 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686011658 PYR/PP interface [polypeptide binding]; other site 710686011659 dimer interface [polypeptide binding]; other site 710686011660 TPP binding site [chemical binding]; other site 710686011661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686011662 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 710686011663 TPP-binding site; other site 710686011664 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710686011665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686011666 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686011667 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710686011668 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710686011669 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710686011670 DNA interaction; other site 710686011671 Metal-binding active site; metal-binding site 710686011672 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710686011673 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710686011674 tetrameric interface [polypeptide binding]; other site 710686011675 NAD binding site [chemical binding]; other site 710686011676 catalytic residues [active] 710686011677 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 710686011678 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 710686011679 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686011680 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710686011681 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686011682 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710686011683 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 710686011684 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 710686011685 putative molybdopterin cofactor binding site [chemical binding]; other site 710686011686 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 710686011687 putative molybdopterin cofactor binding site; other site 710686011688 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 710686011689 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686011690 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686011691 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686011692 acyl-CoA synthetase; Validated; Region: PRK05850 710686011693 acyl-activating enzyme (AAE) consensus motif; other site 710686011694 active site 710686011695 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686011696 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710686011697 active site 710686011698 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686011699 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686011700 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 710686011701 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 710686011702 substrate-cofactor binding pocket; other site 710686011703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686011704 catalytic residue [active] 710686011705 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 710686011706 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686011707 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 710686011708 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 710686011709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686011710 Walker A motif; other site 710686011711 ATP binding site [chemical binding]; other site 710686011712 Walker B motif; other site 710686011713 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 710686011714 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 710686011715 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 710686011716 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 710686011717 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710686011718 oligomer interface [polypeptide binding]; other site 710686011719 active site residues [active] 710686011720 Clp protease; Region: CLP_protease; pfam00574 710686011721 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710686011722 oligomer interface [polypeptide binding]; other site 710686011723 active site residues [active] 710686011724 trigger factor; Provisional; Region: tig; PRK01490 710686011725 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710686011726 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710686011727 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 710686011728 active site 710686011729 catalytic residues [active] 710686011730 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710686011731 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710686011732 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 710686011733 putative DNA binding site [nucleotide binding]; other site 710686011734 catalytic residue [active] 710686011735 putative H2TH interface [polypeptide binding]; other site 710686011736 putative catalytic residues [active] 710686011737 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710686011738 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710686011739 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 710686011740 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 710686011741 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 710686011742 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 710686011743 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710686011744 nucleoside/Zn binding site; other site 710686011745 dimer interface [polypeptide binding]; other site 710686011746 catalytic motif [active] 710686011747 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686011748 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 710686011749 Na binding site [ion binding]; other site 710686011750 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710686011751 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710686011752 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710686011753 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710686011754 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710686011755 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686011756 catalytic loop [active] 710686011757 iron binding site [ion binding]; other site 710686011758 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710686011759 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710686011760 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710686011761 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710686011762 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710686011763 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710686011764 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686011765 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 710686011766 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 710686011767 Zn binding site [ion binding]; other site 710686011768 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686011769 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710686011770 active site 710686011771 Repair protein; Region: Repair_PSII; cl01535 710686011772 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710686011773 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686011774 active site 710686011775 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710686011776 apolar tunnel; other site 710686011777 heme binding site [chemical binding]; other site 710686011778 dimerization interface [polypeptide binding]; other site 710686011779 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 710686011780 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710686011781 active site 710686011782 catalytic site [active] 710686011783 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710686011784 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710686011785 active site 710686011786 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 710686011787 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 710686011788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686011789 Walker A/P-loop; other site 710686011790 ATP binding site [chemical binding]; other site 710686011791 Q-loop/lid; other site 710686011792 ABC transporter signature motif; other site 710686011793 Walker B; other site 710686011794 D-loop; other site 710686011795 H-loop/switch region; other site 710686011796 ABC transporter; Region: ABC_tran_2; pfam12848 710686011797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686011798 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710686011799 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710686011800 dimer interface [polypeptide binding]; other site 710686011801 ssDNA binding site [nucleotide binding]; other site 710686011802 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710686011803 Kinesin-related; Region: Kinesin-related; pfam06548 710686011804 Phage capsid family; Region: Phage_capsid; pfam05065 710686011805 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 710686011806 Phage Terminase; Region: Terminase_1; pfam03354 710686011807 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686011808 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710686011809 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 710686011810 catalytic residues [active] 710686011811 catalytic nucleophile [active] 710686011812 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 710686011813 allophanate hydrolase; Provisional; Region: PRK08186 710686011814 Amidase; Region: Amidase; cl11426 710686011815 Copper resistance protein D; Region: CopD; pfam05425 710686011816 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710686011817 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 710686011818 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 710686011819 putative acyl-acceptor binding pocket; other site 710686011820 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 710686011821 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710686011822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686011823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686011824 putative acyl-acceptor binding pocket; other site 710686011825 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686011826 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686011827 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686011828 MspA; Region: MspA; pfam09203 710686011829 MspA; Region: MspA; pfam09203 710686011830 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 710686011831 O-methyltransferase; Region: Methyltransf_2; pfam00891 710686011832 hypothetical protein; Provisional; Region: PRK06847 710686011833 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686011834 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686011835 FAD binding domain; Region: FAD_binding_4; pfam01565 710686011836 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686011837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686011838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686011839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686011840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686011841 salt bridge; other site 710686011842 non-specific DNA binding site [nucleotide binding]; other site 710686011843 sequence-specific DNA binding site [nucleotide binding]; other site 710686011844 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710686011845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686011846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686011847 DNA binding residues [nucleotide binding] 710686011848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686011849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686011850 ATP binding site [chemical binding]; other site 710686011851 Mg2+ binding site [ion binding]; other site 710686011852 G-X-G motif; other site 710686011853 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686011854 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686011855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686011856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686011857 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 710686011858 PGAP1-like protein; Region: PGAP1; pfam07819 710686011859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686011860 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686011861 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686011862 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686011863 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710686011864 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 710686011865 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686011866 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710686011867 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710686011868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686011869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686011870 WHG domain; Region: WHG; pfam13305 710686011871 RNA polymerase sigma factor; Provisional; Region: PRK12534 710686011872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686011873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 710686011874 DNA binding residues [nucleotide binding] 710686011875 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 710686011876 active site 710686011877 catalytic triad [active] 710686011878 oxyanion hole [active] 710686011879 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686011880 enoyl-CoA hydratase; Provisional; Region: PRK06688 710686011881 substrate binding site [chemical binding]; other site 710686011882 oxyanion hole (OAH) forming residues; other site 710686011883 trimer interface [polypeptide binding]; other site 710686011884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686011885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686011886 active site 710686011887 phosphorylation site [posttranslational modification] 710686011888 intermolecular recognition site; other site 710686011889 dimerization interface [polypeptide binding]; other site 710686011890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686011891 DNA binding residues [nucleotide binding] 710686011892 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710686011893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686011894 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710686011895 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686011896 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686011897 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686011898 ligand binding site [chemical binding]; other site 710686011899 flexible hinge region; other site 710686011900 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710686011901 putative switch regulator; other site 710686011902 non-specific DNA interactions [nucleotide binding]; other site 710686011903 DNA binding site [nucleotide binding] 710686011904 sequence specific DNA binding site [nucleotide binding]; other site 710686011905 putative cAMP binding site [chemical binding]; other site 710686011906 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 710686011907 AAA ATPase domain; Region: AAA_16; pfam13191 710686011908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686011909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686011910 DNA binding residues [nucleotide binding] 710686011911 dimerization interface [polypeptide binding]; other site 710686011912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686011914 ATP binding site [chemical binding]; other site 710686011915 Mg2+ binding site [ion binding]; other site 710686011916 G-X-G motif; other site 710686011917 AAA ATPase domain; Region: AAA_16; pfam13191 710686011918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686011919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686011920 DNA binding residues [nucleotide binding] 710686011921 dimerization interface [polypeptide binding]; other site 710686011922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686011923 ATP binding site [chemical binding]; other site 710686011924 Mg2+ binding site [ion binding]; other site 710686011925 G-X-G motif; other site 710686011926 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 710686011927 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 710686011928 active site pocket [active] 710686011929 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686011930 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710686011931 phosphate binding site [ion binding]; other site 710686011932 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 710686011933 benzoylformate decarboxylase; Reviewed; Region: PRK07092 710686011934 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686011935 PYR/PP interface [polypeptide binding]; other site 710686011936 dimer interface [polypeptide binding]; other site 710686011937 TPP binding site [chemical binding]; other site 710686011938 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686011939 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 710686011940 TPP-binding site [chemical binding]; other site 710686011941 dimer interface [polypeptide binding]; other site 710686011942 GAF domain; Region: GAF; pfam01590 710686011943 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686011944 GAF domain; Region: GAF_3; pfam13492 710686011945 Histidine kinase; Region: HisKA_3; pfam07730 710686011946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686011947 ATP binding site [chemical binding]; other site 710686011948 G-X-G motif; other site 710686011949 malate dehydrogenase; Provisional; Region: PRK13529 710686011950 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710686011951 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 710686011952 NAD(P) binding site [chemical binding]; other site 710686011953 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686011954 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 710686011955 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710686011956 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710686011957 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710686011958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686011959 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 710686011960 Walker A/P-loop; other site 710686011961 ATP binding site [chemical binding]; other site 710686011962 Q-loop/lid; other site 710686011963 ABC transporter signature motif; other site 710686011964 Walker B; other site 710686011965 D-loop; other site 710686011966 H-loop/switch region; other site 710686011967 acyl-coenzyme A oxidase; Region: PLN02526 710686011968 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686011969 active site 710686011970 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686011971 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 710686011972 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710686011973 enoyl-CoA hydratase; Provisional; Region: PRK08252 710686011974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686011975 substrate binding site [chemical binding]; other site 710686011976 oxyanion hole (OAH) forming residues; other site 710686011977 trimer interface [polypeptide binding]; other site 710686011978 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686011979 glycosyltransferase, MGT family; Region: MGT; TIGR01426 710686011980 active site 710686011981 TDP-binding site; other site 710686011982 acceptor substrate-binding pocket; other site 710686011983 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 710686011984 acyl-CoA synthetase; Validated; Region: PRK09192 710686011985 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686011986 acyl-activating enzyme (AAE) consensus motif; other site 710686011987 active site 710686011988 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 710686011989 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 710686011990 malonyl-CoA binding site [chemical binding]; other site 710686011991 dimer interface [polypeptide binding]; other site 710686011992 active site 710686011993 product binding site; other site 710686011994 MMPL family; Region: MMPL; pfam03176 710686011995 MMPL family; Region: MMPL; pfam03176 710686011996 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686011997 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710686011998 Histidine kinase; Region: HisKA_3; pfam07730 710686011999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686012000 ATP binding site [chemical binding]; other site 710686012001 Mg2+ binding site [ion binding]; other site 710686012002 G-X-G motif; other site 710686012003 AAA ATPase domain; Region: AAA_16; pfam13191 710686012004 AAA domain; Region: AAA_22; pfam13401 710686012005 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012007 DNA binding residues [nucleotide binding] 710686012008 dimerization interface [polypeptide binding]; other site 710686012009 AAA ATPase domain; Region: AAA_16; pfam13191 710686012010 AAA domain; Region: AAA_22; pfam13401 710686012011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012013 DNA binding residues [nucleotide binding] 710686012014 dimerization interface [polypeptide binding]; other site 710686012015 Predicted ATPase [General function prediction only]; Region: COG3899 710686012016 AAA ATPase domain; Region: AAA_16; pfam13191 710686012017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012019 DNA binding residues [nucleotide binding] 710686012020 dimerization interface [polypeptide binding]; other site 710686012021 enoyl-CoA hydratase; Provisional; Region: PRK05870 710686012022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012023 substrate binding site [chemical binding]; other site 710686012024 oxyanion hole (OAH) forming residues; other site 710686012025 trimer interface [polypeptide binding]; other site 710686012026 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710686012027 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686012028 E3 interaction surface; other site 710686012029 lipoyl attachment site [posttranslational modification]; other site 710686012030 e3 binding domain; Region: E3_binding; pfam02817 710686012031 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710686012032 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710686012033 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710686012034 alpha subunit interface [polypeptide binding]; other site 710686012035 TPP binding site [chemical binding]; other site 710686012036 heterodimer interface [polypeptide binding]; other site 710686012037 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710686012038 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710686012039 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710686012040 tetramer interface [polypeptide binding]; other site 710686012041 TPP-binding site [chemical binding]; other site 710686012042 heterodimer interface [polypeptide binding]; other site 710686012043 phosphorylation loop region [posttranslational modification] 710686012044 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710686012045 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710686012046 putative active site [active] 710686012047 putative catalytic site [active] 710686012048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012050 active site 710686012051 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710686012052 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686012053 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710686012054 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710686012055 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686012056 carboxyltransferase (CT) interaction site; other site 710686012057 biotinylation site [posttranslational modification]; other site 710686012058 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 710686012059 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686012060 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686012061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686012064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686012065 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 710686012066 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710686012067 active site 710686012068 dimer interface [polypeptide binding]; other site 710686012069 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710686012070 Ligand Binding Site [chemical binding]; other site 710686012071 Molecular Tunnel; other site 710686012072 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 710686012073 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710686012074 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 710686012075 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 710686012076 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686012077 classical (c) SDRs; Region: SDR_c; cd05233 710686012078 NAD(P) binding site [chemical binding]; other site 710686012079 active site 710686012080 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 710686012081 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710686012082 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 710686012083 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 710686012084 catalytic site [active] 710686012085 putative active site [active] 710686012086 putative substrate binding site [chemical binding]; other site 710686012087 dimer interface [polypeptide binding]; other site 710686012088 Uncharacterized conserved protein [Function unknown]; Region: COG0393 710686012089 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 710686012090 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710686012091 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710686012092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710686012093 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710686012094 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710686012095 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710686012096 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686012097 catalytic triad [active] 710686012098 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686012099 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686012100 hypothetical protein; Provisional; Region: PRK07907 710686012101 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 710686012102 active site 710686012103 metal binding site [ion binding]; metal-binding site 710686012104 dimer interface [polypeptide binding]; other site 710686012105 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 710686012106 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710686012107 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 710686012108 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686012109 phosphate binding site [ion binding]; other site 710686012110 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 710686012111 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 710686012112 putative active site [active] 710686012113 putative catalytic site [active] 710686012114 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710686012115 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686012116 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 710686012117 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 710686012118 putative NAD(P) binding site [chemical binding]; other site 710686012119 active site 710686012120 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 710686012121 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710686012122 active site 710686012123 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710686012124 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710686012125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686012126 Walker A/P-loop; other site 710686012127 ATP binding site [chemical binding]; other site 710686012128 Q-loop/lid; other site 710686012129 ABC transporter signature motif; other site 710686012130 Walker B; other site 710686012131 D-loop; other site 710686012132 H-loop/switch region; other site 710686012133 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710686012134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710686012135 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710686012136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686012137 dimer interface [polypeptide binding]; other site 710686012138 conserved gate region; other site 710686012139 putative PBP binding loops; other site 710686012140 ABC-ATPase subunit interface; other site 710686012141 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710686012142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686012143 dimer interface [polypeptide binding]; other site 710686012144 conserved gate region; other site 710686012145 putative PBP binding loops; other site 710686012146 ABC-ATPase subunit interface; other site 710686012147 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710686012148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686012149 DNA binding residues [nucleotide binding] 710686012150 putative dimer interface [polypeptide binding]; other site 710686012151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686012152 ChaB; Region: ChaB; pfam06150 710686012153 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 710686012154 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 710686012155 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686012156 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710686012157 substrate binding site; other site 710686012158 dimer interface; other site 710686012159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686012160 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 710686012161 nucleophile elbow; other site 710686012162 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710686012163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686012164 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710686012165 acyl-activating enzyme (AAE) consensus motif; other site 710686012166 acyl-activating enzyme (AAE) consensus motif; other site 710686012167 putative AMP binding site [chemical binding]; other site 710686012168 putative active site [active] 710686012169 putative CoA binding site [chemical binding]; other site 710686012170 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686012171 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 710686012172 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710686012173 acyl-activating enzyme (AAE) consensus motif; other site 710686012174 putative AMP binding site [chemical binding]; other site 710686012175 putative active site [active] 710686012176 putative CoA binding site [chemical binding]; other site 710686012177 enoyl-CoA hydratase; Provisional; Region: PRK05870 710686012178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012179 substrate binding site [chemical binding]; other site 710686012180 oxyanion hole (OAH) forming residues; other site 710686012181 trimer interface [polypeptide binding]; other site 710686012182 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686012183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012184 NAD(P) binding site [chemical binding]; other site 710686012185 active site 710686012186 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710686012187 SnoaL-like domain; Region: SnoaL_3; pfam13474 710686012188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012190 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686012191 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686012192 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710686012193 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686012194 active site 710686012195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012197 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012198 Cytochrome P450; Region: p450; cl12078 710686012199 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012200 mce related protein; Region: MCE; pfam02470 710686012201 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012202 mce related protein; Region: MCE; pfam02470 710686012203 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012204 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012205 mce related protein; Region: MCE; pfam02470 710686012206 mce related protein; Region: MCE; pfam02470 710686012207 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012208 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012209 mce related protein; Region: MCE; pfam02470 710686012210 mce related protein; Region: MCE; pfam02470 710686012211 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012212 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686012213 Permease; Region: Permease; pfam02405 710686012214 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686012215 Permease; Region: Permease; pfam02405 710686012216 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686012217 active site 710686012218 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686012219 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686012220 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710686012221 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710686012222 NAD binding site [chemical binding]; other site 710686012223 catalytic residues [active] 710686012224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012226 NAD(P) binding site [chemical binding]; other site 710686012227 active site 710686012228 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686012229 classical (c) SDRs; Region: SDR_c; cd05233 710686012230 NAD(P) binding site [chemical binding]; other site 710686012231 active site 710686012232 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 710686012233 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012234 Cytochrome P450; Region: p450; cl12078 710686012235 amidase; Provisional; Region: PRK06170 710686012236 Amidase; Region: Amidase; cl11426 710686012237 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012239 active site 710686012240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012241 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686012242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012243 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686012244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686012245 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686012246 iron-sulfur cluster [ion binding]; other site 710686012247 [2Fe-2S] cluster binding site [ion binding]; other site 710686012248 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686012249 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 710686012250 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710686012251 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686012252 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710686012253 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686012254 thiolase; Provisional; Region: PRK06158 710686012255 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686012256 active site 710686012257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686012258 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686012259 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710686012260 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710686012261 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686012262 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012263 Cytochrome P450; Region: p450; cl12078 710686012264 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686012265 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686012266 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710686012267 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686012268 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012269 Cytochrome P450; Region: p450; cl12078 710686012270 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710686012271 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710686012272 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686012273 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686012274 [2Fe-2S] cluster binding site [ion binding]; other site 710686012275 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710686012276 alpha subunit interface [polypeptide binding]; other site 710686012277 active site 710686012278 substrate binding site [chemical binding]; other site 710686012279 Fe binding site [ion binding]; other site 710686012280 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012282 NAD(P) binding site [chemical binding]; other site 710686012283 active site 710686012284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686012285 catalytic loop [active] 710686012286 iron binding site [ion binding]; other site 710686012287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686012288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686012289 putative DNA binding site [nucleotide binding]; other site 710686012290 putative Zn2+ binding site [ion binding]; other site 710686012291 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710686012292 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686012293 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710686012294 active site 710686012295 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686012296 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686012297 [2Fe-2S] cluster binding site [ion binding]; other site 710686012298 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710686012299 alpha subunit interface [polypeptide binding]; other site 710686012300 active site 710686012301 substrate binding site [chemical binding]; other site 710686012302 Fe binding site [ion binding]; other site 710686012303 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710686012304 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686012305 NAD binding site [chemical binding]; other site 710686012306 catalytic residues [active] 710686012307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686012308 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686012309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012311 active site 710686012312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686012314 NAD(P) binding site [chemical binding]; other site 710686012315 active site 710686012316 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686012317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686012318 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686012319 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686012320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012321 Cytochrome P450; Region: p450; cl12078 710686012322 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686012323 classical (c) SDRs; Region: SDR_c; cd05233 710686012324 NAD(P) binding site [chemical binding]; other site 710686012325 active site 710686012326 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686012327 hydrophobic ligand binding site; other site 710686012328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012330 short chain dehydrogenase; Provisional; Region: PRK06500 710686012331 classical (c) SDRs; Region: SDR_c; cd05233 710686012332 NAD(P) binding site [chemical binding]; other site 710686012333 active site 710686012334 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686012335 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 710686012336 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686012337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012339 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012341 active site 710686012342 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686012343 putative active site [active] 710686012344 putative substrate binding site [chemical binding]; other site 710686012345 ATP binding site [chemical binding]; other site 710686012346 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710686012347 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686012348 NAD(P) binding site [chemical binding]; other site 710686012349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012351 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686012352 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686012353 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686012354 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710686012355 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710686012356 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710686012357 active site 710686012358 iron coordination sites [ion binding]; other site 710686012359 substrate binding pocket [chemical binding]; other site 710686012360 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686012361 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686012362 [2Fe-2S] cluster binding site [ion binding]; other site 710686012363 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710686012364 alpha subunit interface [polypeptide binding]; other site 710686012365 active site 710686012366 substrate binding site [chemical binding]; other site 710686012367 Fe binding site [ion binding]; other site 710686012368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686012369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686012370 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 710686012371 putative effector binding pocket; other site 710686012372 dimerization interface [polypeptide binding]; other site 710686012373 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012375 active site 710686012376 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710686012377 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686012378 dimer interface [polypeptide binding]; other site 710686012379 active site 710686012380 enoyl-CoA hydratase; Provisional; Region: PRK06688 710686012381 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012382 substrate binding site [chemical binding]; other site 710686012383 oxyanion hole (OAH) forming residues; other site 710686012384 trimer interface [polypeptide binding]; other site 710686012385 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686012386 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686012387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012389 NAD(P) binding site [chemical binding]; other site 710686012390 active site 710686012391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012393 active site 710686012394 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686012395 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686012396 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686012397 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686012398 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686012399 [2Fe-2S] cluster binding site [ion binding]; other site 710686012400 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710686012401 alpha subunit interface [polypeptide binding]; other site 710686012402 active site 710686012403 substrate binding site [chemical binding]; other site 710686012404 Fe binding site [ion binding]; other site 710686012405 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686012406 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710686012407 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710686012408 active site 710686012409 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686012410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012411 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012412 active site 710686012413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012415 enoyl-CoA hydratase; Provisional; Region: PRK08290 710686012416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012417 substrate binding site [chemical binding]; other site 710686012418 oxyanion hole (OAH) forming residues; other site 710686012419 trimer interface [polypeptide binding]; other site 710686012420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012422 active site 710686012423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012425 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710686012426 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710686012427 active site 710686012428 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710686012429 catalytic triad [active] 710686012430 dimer interface [polypeptide binding]; other site 710686012431 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012432 Cytochrome P450; Region: p450; cl12078 710686012433 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710686012434 classical (c) SDRs; Region: SDR_c; cd05233 710686012435 NAD(P) binding site [chemical binding]; other site 710686012436 active site 710686012437 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686012438 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686012439 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710686012440 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686012441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710686012442 putative acyl-acceptor binding pocket; other site 710686012443 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686012444 extended (e) SDRs; Region: SDR_e; cd08946 710686012445 NAD(P) binding site [chemical binding]; other site 710686012446 active site 710686012447 substrate binding site [chemical binding]; other site 710686012448 short chain dehydrogenase; Provisional; Region: PRK05876 710686012449 classical (c) SDRs; Region: SDR_c; cd05233 710686012450 NAD(P) binding site [chemical binding]; other site 710686012451 active site 710686012452 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012454 NAD(P) binding site [chemical binding]; other site 710686012455 active site 710686012456 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686012457 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686012458 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686012459 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686012460 enoyl-CoA hydratase; Provisional; Region: PRK12478 710686012461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012462 substrate binding site [chemical binding]; other site 710686012463 oxyanion hole (OAH) forming residues; other site 710686012464 trimer interface [polypeptide binding]; other site 710686012465 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686012466 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686012467 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710686012468 active site 710686012469 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686012470 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686012471 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710686012472 active site 710686012473 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686012474 Cytochrome P450; Region: p450; cl12078 710686012475 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012476 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686012477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686012480 classical (c) SDRs; Region: SDR_c; cd05233 710686012481 NAD(P) binding site [chemical binding]; other site 710686012482 active site 710686012483 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686012484 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686012485 Predicted flavoprotein [General function prediction only]; Region: COG0431 710686012486 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686012487 Putative cyclase; Region: Cyclase; pfam04199 710686012488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012489 NAD(P) binding site [chemical binding]; other site 710686012490 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 710686012491 active site 710686012492 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710686012493 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686012494 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 710686012495 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686012496 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 710686012497 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710686012498 putative active site [active] 710686012499 Fe(II) binding site [ion binding]; other site 710686012500 putative dimer interface [polypeptide binding]; other site 710686012501 putative tetramer interface [polypeptide binding]; other site 710686012502 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 710686012503 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686012504 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686012505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686012506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686012507 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686012508 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710686012509 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 710686012510 L-aspartate oxidase; Provisional; Region: PRK06175 710686012511 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686012512 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 710686012513 Subunit I/III interface [polypeptide binding]; other site 710686012514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012515 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 710686012516 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710686012517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686012518 G1 box; other site 710686012519 GTP/Mg2+ binding site [chemical binding]; other site 710686012520 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710686012521 G4 box; other site 710686012522 G5 box; other site 710686012523 putative acyltransferase; Provisional; Region: PRK05790 710686012524 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686012525 dimer interface [polypeptide binding]; other site 710686012526 active site 710686012527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012528 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710686012529 NAD(P) binding site [chemical binding]; other site 710686012530 active site 710686012531 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686012532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012533 NAD(P) binding site [chemical binding]; other site 710686012534 active site 710686012535 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686012536 classical (c) SDRs; Region: SDR_c; cd05233 710686012537 NAD(P) binding site [chemical binding]; other site 710686012538 active site 710686012539 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686012540 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686012541 active site 710686012542 metal binding site [ion binding]; metal-binding site 710686012543 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686012544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686012545 active site 710686012546 metal binding site [ion binding]; metal-binding site 710686012547 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686012548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012549 substrate binding site [chemical binding]; other site 710686012550 oxyanion hole (OAH) forming residues; other site 710686012551 trimer interface [polypeptide binding]; other site 710686012552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012554 active site 710686012555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012557 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 710686012558 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 710686012559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686012560 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686012561 acyl-activating enzyme (AAE) consensus motif; other site 710686012562 AMP binding site [chemical binding]; other site 710686012563 active site 710686012564 CoA binding site [chemical binding]; other site 710686012565 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710686012566 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710686012567 FAD binding pocket [chemical binding]; other site 710686012568 FAD binding motif [chemical binding]; other site 710686012569 phosphate binding motif [ion binding]; other site 710686012570 beta-alpha-beta structure motif; other site 710686012571 NAD(p) ribose binding residues [chemical binding]; other site 710686012572 NAD binding pocket [chemical binding]; other site 710686012573 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710686012574 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686012575 catalytic loop [active] 710686012576 iron binding site [ion binding]; other site 710686012577 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686012578 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686012579 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686012580 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686012581 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710686012582 B12 binding site [chemical binding]; other site 710686012583 cobalt ligand [ion binding]; other site 710686012584 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 710686012585 short chain dehydrogenase; Provisional; Region: PRK08278 710686012586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012587 NAD(P) binding site [chemical binding]; other site 710686012588 active site 710686012589 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686012590 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686012591 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686012592 acyl-activating enzyme (AAE) consensus motif; other site 710686012593 acyl-activating enzyme (AAE) consensus motif; other site 710686012594 putative AMP binding site [chemical binding]; other site 710686012595 putative active site [active] 710686012596 putative CoA binding site [chemical binding]; other site 710686012597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686012598 dimerization interface [polypeptide binding]; other site 710686012599 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686012600 cyclase homology domain; Region: CHD; cd07302 710686012601 nucleotidyl binding site; other site 710686012602 metal binding site [ion binding]; metal-binding site 710686012603 dimer interface [polypeptide binding]; other site 710686012604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686012605 metabolite-proton symporter; Region: 2A0106; TIGR00883 710686012606 putative substrate translocation pore; other site 710686012607 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710686012608 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 710686012609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710686012610 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710686012611 DNA binding residues [nucleotide binding] 710686012612 TOBE domain; Region: TOBE; cl01440 710686012613 Amidohydrolase; Region: Amidohydro_2; pfam04909 710686012614 Cupin domain; Region: Cupin_2; cl17218 710686012615 Helix-turn-helix domain; Region: HTH_18; pfam12833 710686012616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686012617 AAA ATPase domain; Region: AAA_16; pfam13191 710686012618 AAA domain; Region: AAA_22; pfam13401 710686012619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012621 DNA binding residues [nucleotide binding] 710686012622 dimerization interface [polypeptide binding]; other site 710686012623 Glucitol operon activator protein (GutM); Region: GutM; cl01890 710686012624 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710686012625 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 710686012626 active site 710686012627 dimerization interface [polypeptide binding]; other site 710686012628 ribonuclease PH; Reviewed; Region: rph; PRK00173 710686012629 Ribonuclease PH; Region: RNase_PH_bact; cd11362 710686012630 hexamer interface [polypeptide binding]; other site 710686012631 active site 710686012632 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 710686012633 glutamate racemase; Provisional; Region: PRK00865 710686012634 Rhomboid family; Region: Rhomboid; cl11446 710686012635 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710686012636 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710686012637 dimer interface [polypeptide binding]; other site 710686012638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686012639 catalytic residue [active] 710686012640 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 710686012641 MoaE interaction surface [polypeptide binding]; other site 710686012642 MoeB interaction surface [polypeptide binding]; other site 710686012643 thiocarboxylated glycine; other site 710686012644 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 710686012645 MPN+ (JAMM) motif; other site 710686012646 Zinc-binding site [ion binding]; other site 710686012647 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 710686012648 putative active site pocket [active] 710686012649 cleavage site 710686012650 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 710686012651 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 710686012652 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 710686012653 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 710686012654 active site 710686012655 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 710686012656 DEAD/DEAH box helicase; Region: DEAD; pfam00270 710686012657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710686012658 putative Mg++ binding site [ion binding]; other site 710686012659 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 710686012660 Predicted metalloprotease [General function prediction only]; Region: COG2321 710686012661 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710686012662 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 710686012663 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 710686012664 putative homodimer interface [polypeptide binding]; other site 710686012665 putative active site pocket [active] 710686012666 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 710686012667 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 710686012668 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 710686012669 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710686012670 active site 710686012671 homodimer interface [polypeptide binding]; other site 710686012672 catalytic site [active] 710686012673 acceptor binding site [chemical binding]; other site 710686012674 glycogen branching enzyme; Provisional; Region: PRK05402 710686012675 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 710686012676 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 710686012677 active site 710686012678 catalytic site [active] 710686012679 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 710686012680 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 710686012681 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 710686012682 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710686012683 putative acyltransferase; Provisional; Region: PRK05790 710686012684 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686012685 dimer interface [polypeptide binding]; other site 710686012686 active site 710686012687 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710686012688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686012689 dimer interface [polypeptide binding]; other site 710686012690 substrate binding site [chemical binding]; other site 710686012691 metal binding site [ion binding]; metal-binding site 710686012692 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 710686012693 hypothetical protein; Provisional; Region: PRK03298 710686012694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686012695 dimerization interface [polypeptide binding]; other site 710686012696 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686012697 cyclase homology domain; Region: CHD; cd07302 710686012698 nucleotidyl binding site; other site 710686012699 metal binding site [ion binding]; metal-binding site 710686012700 dimer interface [polypeptide binding]; other site 710686012701 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710686012702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710686012703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686012704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686012705 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 710686012706 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 710686012707 Subunit I/III interface [polypeptide binding]; other site 710686012708 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686012709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686012710 DNA-binding site [nucleotide binding]; DNA binding site 710686012711 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686012712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012713 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686012714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012715 active site 710686012716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012718 active site 710686012719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686012720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012721 NAD(P) binding site [chemical binding]; other site 710686012722 active site 710686012723 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686012724 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710686012725 dimer interface [polypeptide binding]; other site 710686012726 active site 710686012727 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 710686012728 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 710686012729 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710686012730 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 710686012731 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710686012732 active site 710686012733 catalytic residues [active] 710686012734 metal binding site [ion binding]; metal-binding site 710686012735 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 710686012736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686012737 NAD(P) binding site [chemical binding]; other site 710686012738 active site 710686012739 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012740 enoyl-CoA hydratase; Provisional; Region: PRK07658 710686012741 substrate binding site [chemical binding]; other site 710686012742 oxyanion hole (OAH) forming residues; other site 710686012743 trimer interface [polypeptide binding]; other site 710686012744 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 710686012745 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686012746 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686012747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012748 enoyl-CoA hydratase; Provisional; Region: PRK09245 710686012749 substrate binding site [chemical binding]; other site 710686012750 oxyanion hole (OAH) forming residues; other site 710686012751 trimer interface [polypeptide binding]; other site 710686012752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012753 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686012754 substrate binding site [chemical binding]; other site 710686012755 oxyanion hole (OAH) forming residues; other site 710686012756 trimer interface [polypeptide binding]; other site 710686012757 Protein of unknown function (DUF964); Region: DUF964; cl01483 710686012758 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686012759 Phosphotransferase enzyme family; Region: APH; pfam01636 710686012760 putative active site [active] 710686012761 putative substrate binding site [chemical binding]; other site 710686012762 ATP binding site [chemical binding]; other site 710686012763 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 710686012764 NAD(P) binding site [chemical binding]; other site 710686012765 substrate binding site [chemical binding]; other site 710686012766 homotetramer interface [polypeptide binding]; other site 710686012767 active site 710686012768 homodimer interface [polypeptide binding]; other site 710686012769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012770 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686012771 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686012772 active site 710686012773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012775 DNA binding residues [nucleotide binding] 710686012776 dimerization interface [polypeptide binding]; other site 710686012777 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710686012778 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686012779 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686012780 active site 710686012781 ATP binding site [chemical binding]; other site 710686012782 substrate binding site [chemical binding]; other site 710686012783 activation loop (A-loop); other site 710686012784 AAA ATPase domain; Region: AAA_16; pfam13191 710686012785 AAA domain; Region: AAA_22; pfam13401 710686012786 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686012787 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686012788 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012789 mce related protein; Region: MCE; pfam02470 710686012790 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012791 mce related protein; Region: MCE; pfam02470 710686012792 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012793 mce related protein; Region: MCE; pfam02470 710686012794 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012795 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012796 mce related protein; Region: MCE; pfam02470 710686012797 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012798 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686012799 mce related protein; Region: MCE; pfam02470 710686012800 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012801 mce related protein; Region: MCE; pfam02470 710686012802 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686012803 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686012804 Permease; Region: Permease; pfam02405 710686012805 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686012806 Permease; Region: Permease; pfam02405 710686012807 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710686012808 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686012809 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710686012810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012811 substrate binding site [chemical binding]; other site 710686012812 oxyanion hole (OAH) forming residues; other site 710686012813 trimer interface [polypeptide binding]; other site 710686012814 GAF domain; Region: GAF_2; pfam13185 710686012815 GAF domain; Region: GAF_3; pfam13492 710686012816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686012817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012818 DNA binding residues [nucleotide binding] 710686012819 dimerization interface [polypeptide binding]; other site 710686012820 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710686012821 GAF domain; Region: GAF; cl17456 710686012822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686012823 DNA binding residues [nucleotide binding] 710686012824 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686012825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686012826 NAD(P) binding site [chemical binding]; other site 710686012827 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686012828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012829 substrate binding site [chemical binding]; other site 710686012830 oxyanion hole (OAH) forming residues; other site 710686012831 trimer interface [polypeptide binding]; other site 710686012832 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 710686012833 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686012834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686012835 acyl-activating enzyme (AAE) consensus motif; other site 710686012836 AMP binding site [chemical binding]; other site 710686012837 active site 710686012838 CoA binding site [chemical binding]; other site 710686012839 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686012840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686012841 active site 710686012842 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 710686012843 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 710686012844 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 710686012845 acyl-activating enzyme (AAE) consensus motif; other site 710686012846 putative AMP binding site [chemical binding]; other site 710686012847 putative active site [active] 710686012848 putative CoA binding site [chemical binding]; other site 710686012849 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686012850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686012851 DNA-binding site [nucleotide binding]; DNA binding site 710686012852 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686012853 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710686012854 putative active site [active] 710686012855 putative catalytic site [active] 710686012856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686012857 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710686012858 substrate binding site [chemical binding]; other site 710686012859 oxyanion hole (OAH) forming residues; other site 710686012860 trimer interface [polypeptide binding]; other site 710686012861 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 710686012862 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 710686012863 putative acyl-acceptor binding pocket; other site 710686012864 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710686012865 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710686012866 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686012867 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686012868 putative acyl-acceptor binding pocket; other site 710686012869 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686012870 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686012871 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 710686012872 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 710686012873 catalytic Zn binding site [ion binding]; other site 710686012874 NAD binding site [chemical binding]; other site 710686012875 structural Zn binding site [ion binding]; other site 710686012876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686012877 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710686012878 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710686012879 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686012880 Cytochrome P450; Region: p450; cl12078 710686012881 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710686012882 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686012883 NAD binding site [chemical binding]; other site 710686012884 catalytic residues [active] 710686012885 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686012886 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 710686012887 FMN-binding pocket [chemical binding]; other site 710686012888 flavin binding motif; other site 710686012889 phosphate binding motif [ion binding]; other site 710686012890 beta-alpha-beta structure motif; other site 710686012891 NAD binding pocket [chemical binding]; other site 710686012892 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686012893 catalytic loop [active] 710686012894 iron binding site [ion binding]; other site 710686012895 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686012896 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686012897 iron-sulfur cluster [ion binding]; other site 710686012898 [2Fe-2S] cluster binding site [ion binding]; other site 710686012899 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710686012900 hydrophobic ligand binding site; other site 710686012901 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 710686012902 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 710686012903 AlkA N-terminal domain; Region: AlkA_N; pfam06029 710686012904 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710686012905 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710686012906 minor groove reading motif; other site 710686012907 helix-hairpin-helix signature motif; other site 710686012908 substrate binding pocket [chemical binding]; other site 710686012909 active site 710686012910 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710686012911 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 710686012912 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710686012913 DNA binding site [nucleotide binding] 710686012914 active site 710686012915 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686012916 putative hydrophobic ligand binding site [chemical binding]; other site 710686012917 protein interface [polypeptide binding]; other site 710686012918 gate; other site 710686012919 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 710686012920 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 710686012921 hinge; other site 710686012922 active site 710686012923 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 710686012924 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 710686012925 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 710686012926 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 710686012927 gamma subunit interface [polypeptide binding]; other site 710686012928 epsilon subunit interface [polypeptide binding]; other site 710686012929 LBP interface [polypeptide binding]; other site 710686012930 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710686012931 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710686012932 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710686012933 alpha subunit interaction interface [polypeptide binding]; other site 710686012934 Walker A motif; other site 710686012935 ATP binding site [chemical binding]; other site 710686012936 Walker B motif; other site 710686012937 inhibitor binding site; inhibition site 710686012938 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710686012939 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 710686012940 core domain interface [polypeptide binding]; other site 710686012941 delta subunit interface [polypeptide binding]; other site 710686012942 epsilon subunit interface [polypeptide binding]; other site 710686012943 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710686012944 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710686012945 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710686012946 beta subunit interaction interface [polypeptide binding]; other site 710686012947 Walker A motif; other site 710686012948 ATP binding site [chemical binding]; other site 710686012949 Walker B motif; other site 710686012950 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710686012951 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 710686012952 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710686012953 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 710686012954 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 710686012955 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710686012956 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 710686012957 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 710686012958 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 710686012959 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 710686012960 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 710686012961 Mg++ binding site [ion binding]; other site 710686012962 putative catalytic motif [active] 710686012963 substrate binding site [chemical binding]; other site 710686012964 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 710686012965 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 710686012966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686012967 S-adenosylmethionine binding site [chemical binding]; other site 710686012968 peptide chain release factor 1; Validated; Region: prfA; PRK00591 710686012969 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710686012970 RF-1 domain; Region: RF-1; pfam00472 710686012971 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 710686012972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686012973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686012974 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 710686012975 transcription termination factor Rho; Provisional; Region: PRK12608 710686012976 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710686012977 RNA binding site [nucleotide binding]; other site 710686012978 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 710686012979 multimer interface [polypeptide binding]; other site 710686012980 Walker A motif; other site 710686012981 ATP binding site [chemical binding]; other site 710686012982 Walker B motif; other site 710686012983 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 710686012984 threonine synthase; Reviewed; Region: PRK06721 710686012985 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 710686012986 homodimer interface [polypeptide binding]; other site 710686012987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686012988 catalytic residue [active] 710686012989 homoserine dehydrogenase; Provisional; Region: PRK06349 710686012990 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710686012991 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 710686012992 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 710686012993 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710686012994 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710686012995 active site 710686012996 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686012997 substrate binding site [chemical binding]; other site 710686012998 catalytic residues [active] 710686012999 dimer interface [polypeptide binding]; other site 710686013000 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 710686013001 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 710686013002 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710686013003 active site 710686013004 HIGH motif; other site 710686013005 KMSK motif region; other site 710686013006 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 710686013007 tRNA binding surface [nucleotide binding]; other site 710686013008 anticodon binding site; other site 710686013009 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 710686013010 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 710686013011 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 710686013012 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710686013013 putative catalytic site [active] 710686013014 putative metal binding site [ion binding]; other site 710686013015 putative phosphate binding site [ion binding]; other site 710686013016 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686013017 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013018 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013019 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686013020 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013021 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710686013022 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013023 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013024 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686013025 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 710686013026 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710686013027 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686013028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686013029 active site 710686013030 metal binding site [ion binding]; metal-binding site 710686013031 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686013032 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686013033 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 710686013034 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 710686013035 gating phenylalanine in ion channel; other site 710686013036 RNA polymerase factor sigma-70; Validated; Region: PRK08241 710686013037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686013038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686013039 DNA binding residues [nucleotide binding] 710686013040 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686013041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710686013042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013043 S-adenosylmethionine binding site [chemical binding]; other site 710686013044 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686013045 Nitronate monooxygenase; Region: NMO; pfam03060 710686013046 FMN binding site [chemical binding]; other site 710686013047 substrate binding site [chemical binding]; other site 710686013048 putative catalytic residue [active] 710686013049 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 710686013050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686013051 metal binding site [ion binding]; metal-binding site 710686013052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710686013053 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 710686013054 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686013055 Creatinine amidohydrolase; Region: Creatininase; pfam02633 710686013056 Rrf2 family protein; Region: rrf2_super; TIGR00738 710686013057 Transcriptional regulator; Region: Rrf2; pfam02082 710686013058 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 710686013059 Isochorismatase family; Region: Isochorismatase; pfam00857 710686013060 catalytic triad [active] 710686013061 conserved cis-peptide bond; other site 710686013062 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710686013063 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710686013064 active site 710686013065 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 710686013066 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 710686013067 CysD dimerization site [polypeptide binding]; other site 710686013068 G1 box; other site 710686013069 putative GEF interaction site [polypeptide binding]; other site 710686013070 GTP/Mg2+ binding site [chemical binding]; other site 710686013071 Switch I region; other site 710686013072 G2 box; other site 710686013073 G3 box; other site 710686013074 Switch II region; other site 710686013075 G4 box; other site 710686013076 G5 box; other site 710686013077 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 710686013078 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 710686013079 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 710686013080 ligand-binding site [chemical binding]; other site 710686013081 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 710686013082 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710686013083 Active Sites [active] 710686013084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686013085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686013086 substrate binding pocket [chemical binding]; other site 710686013087 membrane-bound complex binding site; other site 710686013088 hinge residues; other site 710686013089 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686013090 CoenzymeA binding site [chemical binding]; other site 710686013091 subunit interaction site [polypeptide binding]; other site 710686013092 PHB binding site; other site 710686013093 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 710686013094 active site clefts [active] 710686013095 zinc binding site [ion binding]; other site 710686013096 dimer interface [polypeptide binding]; other site 710686013097 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710686013098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686013099 active site 710686013100 GtrA-like protein; Region: GtrA; pfam04138 710686013101 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710686013102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686013103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686013104 dimerization interface [polypeptide binding]; other site 710686013105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686013106 dimer interface [polypeptide binding]; other site 710686013107 phosphorylation site [posttranslational modification] 710686013108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686013109 ATP binding site [chemical binding]; other site 710686013110 Mg2+ binding site [ion binding]; other site 710686013111 G-X-G motif; other site 710686013112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686013113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686013114 active site 710686013115 phosphorylation site [posttranslational modification] 710686013116 intermolecular recognition site; other site 710686013117 dimerization interface [polypeptide binding]; other site 710686013118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686013119 DNA binding site [nucleotide binding] 710686013120 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710686013121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686013122 dimer interface [polypeptide binding]; other site 710686013123 conserved gate region; other site 710686013124 putative PBP binding loops; other site 710686013125 ABC-ATPase subunit interface; other site 710686013126 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710686013127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686013128 dimer interface [polypeptide binding]; other site 710686013129 conserved gate region; other site 710686013130 putative PBP binding loops; other site 710686013131 ABC-ATPase subunit interface; other site 710686013132 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710686013133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686013134 Walker A/P-loop; other site 710686013135 ATP binding site [chemical binding]; other site 710686013136 Q-loop/lid; other site 710686013137 ABC transporter signature motif; other site 710686013138 Walker B; other site 710686013139 D-loop; other site 710686013140 H-loop/switch region; other site 710686013141 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 710686013142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 710686013143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686013144 Walker A/P-loop; other site 710686013145 ATP binding site [chemical binding]; other site 710686013146 Q-loop/lid; other site 710686013147 ABC transporter signature motif; other site 710686013148 Walker B; other site 710686013149 D-loop; other site 710686013150 H-loop/switch region; other site 710686013151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686013152 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710686013153 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710686013154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686013155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686013156 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 710686013157 active site 710686013158 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710686013159 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710686013160 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710686013161 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 710686013162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710686013163 Walker A/P-loop; other site 710686013164 ATP binding site [chemical binding]; other site 710686013165 Q-loop/lid; other site 710686013166 ABC transporter signature motif; other site 710686013167 Walker B; other site 710686013168 D-loop; other site 710686013169 H-loop/switch region; other site 710686013170 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 710686013171 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686013172 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686013173 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 710686013174 active sites [active] 710686013175 tetramer interface [polypeptide binding]; other site 710686013176 choline dehydrogenase; Validated; Region: PRK02106 710686013177 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710686013178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686013180 putative substrate translocation pore; other site 710686013181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013182 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686013183 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686013184 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686013185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686013186 Walker A/P-loop; other site 710686013187 ATP binding site [chemical binding]; other site 710686013188 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 710686013189 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 710686013190 active site 710686013191 metal binding site [ion binding]; metal-binding site 710686013192 DNA binding site [nucleotide binding] 710686013193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686013194 catalytic core [active] 710686013195 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710686013196 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710686013197 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710686013198 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686013199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686013200 Walker A/P-loop; other site 710686013201 ATP binding site [chemical binding]; other site 710686013202 Q-loop/lid; other site 710686013203 ABC transporter signature motif; other site 710686013204 Walker B; other site 710686013205 D-loop; other site 710686013206 H-loop/switch region; other site 710686013207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686013208 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 710686013209 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710686013210 Walker A/P-loop; other site 710686013211 ATP binding site [chemical binding]; other site 710686013212 Q-loop/lid; other site 710686013213 ABC transporter signature motif; other site 710686013214 Walker B; other site 710686013215 D-loop; other site 710686013216 H-loop/switch region; other site 710686013217 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686013218 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686013219 molybdopterin cofactor binding site; other site 710686013220 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710686013221 molybdopterin cofactor binding site; other site 710686013222 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 710686013223 putative active site [active] 710686013224 dimerization interface [polypeptide binding]; other site 710686013225 putative tRNAtyr binding site [nucleotide binding]; other site 710686013226 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686013227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013228 S-adenosylmethionine binding site [chemical binding]; other site 710686013229 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710686013230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710686013231 metal-binding site [ion binding] 710686013232 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710686013233 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710686013234 metal-binding site [ion binding] 710686013235 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686013236 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710686013237 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686013238 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686013239 active site 710686013240 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686013241 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686013242 homodimer interface [polypeptide binding]; other site 710686013243 active site 710686013244 TDP-binding site; other site 710686013245 acceptor substrate-binding pocket; other site 710686013246 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686013247 cyclase homology domain; Region: CHD; cd07302 710686013248 nucleotidyl binding site; other site 710686013249 metal binding site [ion binding]; metal-binding site 710686013250 dimer interface [polypeptide binding]; other site 710686013251 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 710686013252 putative active site [active] 710686013253 amidase; Provisional; Region: PRK12470 710686013254 Amidase; Region: Amidase; cl11426 710686013255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686013256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013257 putative substrate translocation pore; other site 710686013258 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710686013259 putative dimer interface [polypeptide binding]; other site 710686013260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686013261 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 710686013262 HIT family signature motif; other site 710686013263 catalytic residue [active] 710686013264 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686013265 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710686013266 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710686013267 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 710686013268 Fe-S cluster binding site [ion binding]; other site 710686013269 DNA binding site [nucleotide binding] 710686013270 active site 710686013271 H+ Antiporter protein; Region: 2A0121; TIGR00900 710686013272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013273 AAA ATPase domain; Region: AAA_16; pfam13191 710686013274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686013275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686013276 DNA binding residues [nucleotide binding] 710686013277 dimerization interface [polypeptide binding]; other site 710686013278 FAD binding domain; Region: FAD_binding_4; pfam01565 710686013279 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710686013280 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686013281 Cytochrome P450; Region: p450; cl12078 710686013282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013284 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 710686013285 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710686013286 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 710686013287 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710686013288 ATP binding site [chemical binding]; other site 710686013289 Mg++ binding site [ion binding]; other site 710686013290 motif III; other site 710686013291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686013292 nucleotide binding region [chemical binding]; other site 710686013293 ATP-binding site [chemical binding]; other site 710686013294 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 710686013295 putative RNA binding site [nucleotide binding]; other site 710686013296 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 710686013297 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686013298 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710686013299 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 710686013300 RNase_H superfamily; Region: RNase_H_2; pfam13482 710686013301 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710686013302 AAA domain; Region: AAA_30; pfam13604 710686013303 AAA domain; Region: AAA_12; pfam13087 710686013304 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686013305 FAD binding domain; Region: FAD_binding_4; pfam01565 710686013306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686013308 putative substrate translocation pore; other site 710686013309 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 710686013310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013311 putative substrate translocation pore; other site 710686013312 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 710686013313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710686013314 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 710686013315 TPP-binding site [chemical binding]; other site 710686013316 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 710686013317 Cutinase; Region: Cutinase; pfam01083 710686013318 hypothetical protein; Provisional; Region: PRK06194 710686013319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686013320 NAD(P) binding site [chemical binding]; other site 710686013321 active site 710686013322 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 710686013323 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710686013324 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710686013325 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 710686013326 NAD(P) binding pocket [chemical binding]; other site 710686013327 malate dehydrogenase; Provisional; Region: PRK05442 710686013328 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 710686013329 NAD(P) binding site [chemical binding]; other site 710686013330 dimer interface [polypeptide binding]; other site 710686013331 malate binding site [chemical binding]; other site 710686013332 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710686013333 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710686013334 oligomer interface [polypeptide binding]; other site 710686013335 metal binding site [ion binding]; metal-binding site 710686013336 metal binding site [ion binding]; metal-binding site 710686013337 putative Cl binding site [ion binding]; other site 710686013338 basic sphincter; other site 710686013339 hydrophobic gate; other site 710686013340 periplasmic entrance; other site 710686013341 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 710686013342 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710686013343 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710686013344 Walker A/P-loop; other site 710686013345 ATP binding site [chemical binding]; other site 710686013346 Q-loop/lid; other site 710686013347 ABC transporter signature motif; other site 710686013348 Walker B; other site 710686013349 D-loop; other site 710686013350 H-loop/switch region; other site 710686013351 TOBE domain; Region: TOBE; pfam03459 710686013352 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710686013353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686013354 dimer interface [polypeptide binding]; other site 710686013355 conserved gate region; other site 710686013356 putative PBP binding loops; other site 710686013357 ABC-ATPase subunit interface; other site 710686013358 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710686013359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686013360 dimer interface [polypeptide binding]; other site 710686013361 conserved gate region; other site 710686013362 putative PBP binding loops; other site 710686013363 ABC-ATPase subunit interface; other site 710686013364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710686013365 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710686013366 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710686013367 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710686013368 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710686013369 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 710686013370 PRC-barrel domain; Region: PRC; pfam05239 710686013371 MgtE intracellular N domain; Region: MgtE_N; smart00924 710686013372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 710686013373 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 710686013374 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710686013375 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710686013376 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710686013377 Domain of unknown function DUF59; Region: DUF59; pfam01883 710686013378 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710686013379 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 710686013380 sec-independent translocase; Provisional; Region: PRK03100 710686013381 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710686013382 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686013383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710686013384 protein binding site [polypeptide binding]; other site 710686013385 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 710686013386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686013387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686013388 DNA binding residues [nucleotide binding] 710686013389 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710686013390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013391 S-adenosylmethionine binding site [chemical binding]; other site 710686013392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013394 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710686013395 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710686013396 Walker A/P-loop; other site 710686013397 ATP binding site [chemical binding]; other site 710686013398 Q-loop/lid; other site 710686013399 ABC transporter signature motif; other site 710686013400 Walker B; other site 710686013401 D-loop; other site 710686013402 H-loop/switch region; other site 710686013403 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 710686013404 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710686013405 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710686013406 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710686013407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686013408 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 710686013409 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710686013410 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686013411 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710686013412 putative NAD(P) binding site [chemical binding]; other site 710686013413 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 710686013414 NIPSNAP; Region: NIPSNAP; pfam07978 710686013415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013417 WHG domain; Region: WHG; pfam13305 710686013418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686013419 MarR family; Region: MarR_2; pfam12802 710686013420 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 710686013421 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 710686013422 ligand binding site; other site 710686013423 oligomer interface; other site 710686013424 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 710686013425 dimer interface [polypeptide binding]; other site 710686013426 N-terminal domain interface [polypeptide binding]; other site 710686013427 sulfate 1 binding site; other site 710686013428 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 710686013429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686013430 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 710686013431 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 710686013432 DivIVA domain; Region: DivI1A_domain; TIGR03544 710686013433 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686013434 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686013435 cyclase homology domain; Region: CHD; cd07302 710686013436 nucleotidyl binding site; other site 710686013437 metal binding site [ion binding]; metal-binding site 710686013438 dimer interface [polypeptide binding]; other site 710686013439 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 710686013440 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710686013441 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 710686013442 dihydropteroate synthase; Region: DHPS; TIGR01496 710686013443 substrate binding pocket [chemical binding]; other site 710686013444 dimer interface [polypeptide binding]; other site 710686013445 inhibitor binding site; inhibition site 710686013446 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 710686013447 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 710686013448 acyl-activating enzyme (AAE) consensus motif; other site 710686013449 putative AMP binding site [chemical binding]; other site 710686013450 putative active site [active] 710686013451 putative CoA binding site [chemical binding]; other site 710686013452 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 710686013453 AAA domain; Region: AAA_22; pfam13401 710686013454 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710686013455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686013456 Walker A/P-loop; other site 710686013457 ATP binding site [chemical binding]; other site 710686013458 Q-loop/lid; other site 710686013459 ABC transporter signature motif; other site 710686013460 Walker B; other site 710686013461 D-loop; other site 710686013462 H-loop/switch region; other site 710686013463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710686013464 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 710686013465 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 710686013466 metal binding site [ion binding]; metal-binding site 710686013467 putative dimer interface [polypeptide binding]; other site 710686013468 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 710686013469 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 710686013470 putative trimer interface [polypeptide binding]; other site 710686013471 putative CoA binding site [chemical binding]; other site 710686013472 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710686013473 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710686013474 active site 710686013475 TDP-binding site; other site 710686013476 acceptor substrate-binding pocket; other site 710686013477 MarR family; Region: MarR_2; pfam12802 710686013478 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710686013479 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710686013480 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 710686013481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 710686013482 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 710686013483 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 710686013484 active site 710686013485 acyl-CoA synthetase; Validated; Region: PRK07787 710686013486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686013487 acyl-activating enzyme (AAE) consensus motif; other site 710686013488 AMP binding site [chemical binding]; other site 710686013489 active site 710686013490 CoA binding site [chemical binding]; other site 710686013491 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710686013492 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710686013493 dimer interface [polypeptide binding]; other site 710686013494 active site 710686013495 ADP-ribose binding site [chemical binding]; other site 710686013496 nudix motif; other site 710686013497 metal binding site [ion binding]; metal-binding site 710686013498 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710686013499 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 710686013500 SnoaL-like domain; Region: SnoaL_3; pfam13474 710686013501 Proline dehydrogenase; Region: Pro_dh; cl03282 710686013502 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 710686013503 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 710686013504 Glutamate binding site [chemical binding]; other site 710686013505 NAD binding site [chemical binding]; other site 710686013506 catalytic residues [active] 710686013507 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710686013508 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686013509 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686013510 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 710686013511 DNA binding residues [nucleotide binding] 710686013512 B12 binding domain; Region: B12-binding_2; cl03653 710686013513 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710686013514 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 710686013515 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 710686013516 active site 710686013517 metal binding site [ion binding]; metal-binding site 710686013518 nudix motif; other site 710686013519 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686013520 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686013521 [2Fe-2S] cluster binding site [ion binding]; other site 710686013522 iron-sulfur cluster [ion binding]; other site 710686013523 Uncharacterized conserved protein [Function unknown]; Region: COG3349 710686013524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013525 S-adenosylmethionine binding site [chemical binding]; other site 710686013526 ubiquinone biosynthesis methyltransferase; Region: PLN02232 710686013527 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 710686013528 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 710686013529 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 710686013530 active site lid residues [active] 710686013531 substrate binding pocket [chemical binding]; other site 710686013532 catalytic residues [active] 710686013533 substrate-Mg2+ binding site; other site 710686013534 aspartate-rich region 1; other site 710686013535 aspartate-rich region 2; other site 710686013536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686013537 phytoene desaturase; Region: crtI_fam; TIGR02734 710686013538 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710686013539 substrate binding pocket [chemical binding]; other site 710686013540 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710686013541 chain length determination region; other site 710686013542 substrate-Mg2+ binding site; other site 710686013543 catalytic residues [active] 710686013544 aspartate-rich region 1; other site 710686013545 active site lid residues [active] 710686013546 aspartate-rich region 2; other site 710686013547 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 710686013548 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686013549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686013550 homodimer interface [polypeptide binding]; other site 710686013551 catalytic residue [active] 710686013552 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 710686013553 4Fe-4S binding domain; Region: Fer4; pfam00037 710686013554 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686013555 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710686013556 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 710686013557 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710686013558 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 710686013559 active site 710686013560 FMN binding site [chemical binding]; other site 710686013561 2,4-decadienoyl-CoA binding site; other site 710686013562 catalytic residue [active] 710686013563 4Fe-4S cluster binding site [ion binding]; other site 710686013564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686013565 Uncharacterized conserved protein [Function unknown]; Region: COG2353 710686013566 FO synthase; Reviewed; Region: fbiC; PRK09234 710686013567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686013568 FeS/SAM binding site; other site 710686013569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686013570 FeS/SAM binding site; other site 710686013571 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 710686013572 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 710686013573 putative ion selectivity filter; other site 710686013574 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710686013575 putative pore gating glutamate residue; other site 710686013576 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710686013577 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710686013578 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710686013579 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710686013580 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710686013581 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 710686013582 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 710686013583 G1 box; other site 710686013584 putative GEF interaction site [polypeptide binding]; other site 710686013585 GTP/Mg2+ binding site [chemical binding]; other site 710686013586 Switch I region; other site 710686013587 G2 box; other site 710686013588 G3 box; other site 710686013589 Switch II region; other site 710686013590 G4 box; other site 710686013591 G5 box; other site 710686013592 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 710686013593 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 710686013594 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 710686013595 active site 710686013596 8-oxo-dGMP binding site [chemical binding]; other site 710686013597 nudix motif; other site 710686013598 metal binding site [ion binding]; metal-binding site 710686013599 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 710686013600 aromatic arch; other site 710686013601 DCoH dimer interaction site [polypeptide binding]; other site 710686013602 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 710686013603 DCoH tetramer interaction site [polypeptide binding]; other site 710686013604 substrate binding site [chemical binding]; other site 710686013605 FMN binding site [chemical binding]; other site 710686013606 Nitroreductase family; Region: Nitroreductase; pfam00881 710686013607 dimer interface [polypeptide binding]; other site 710686013608 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 710686013609 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710686013610 catalytic residues [active] 710686013611 catalytic nucleophile [active] 710686013612 Presynaptic Site I dimer interface [polypeptide binding]; other site 710686013613 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 710686013614 Synaptic Flat tetramer interface [polypeptide binding]; other site 710686013615 Synaptic Site I dimer interface [polypeptide binding]; other site 710686013616 uncharacterized HhH-GPD family protein; Region: TIGR03252 710686013617 minor groove reading motif; other site 710686013618 helix-hairpin-helix signature motif; other site 710686013619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013621 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686013622 putative active site [active] 710686013623 putative substrate binding site [chemical binding]; other site 710686013624 ATP binding site [chemical binding]; other site 710686013625 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686013626 classical (c) SDRs; Region: SDR_c; cd05233 710686013627 NAD(P) binding site [chemical binding]; other site 710686013628 active site 710686013629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686013630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686013631 active site 710686013632 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 710686013633 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686013634 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 710686013635 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686013636 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686013637 Predicted transcriptional regulators [Transcription]; Region: COG1725 710686013638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686013639 DNA-binding site [nucleotide binding]; DNA binding site 710686013640 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 710686013641 NAD-dependent deacetylase; Provisional; Region: PRK00481 710686013642 NAD+ binding site [chemical binding]; other site 710686013643 substrate binding site [chemical binding]; other site 710686013644 Zn binding site [ion binding]; other site 710686013645 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686013646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013647 S-adenosylmethionine binding site [chemical binding]; other site 710686013648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013650 WHG domain; Region: WHG; pfam13305 710686013651 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686013652 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710686013653 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686013654 FMN binding site [chemical binding]; other site 710686013655 substrate binding site [chemical binding]; other site 710686013656 putative catalytic residue [active] 710686013657 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710686013658 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 710686013659 NAD binding site [chemical binding]; other site 710686013660 homodimer interface [polypeptide binding]; other site 710686013661 homotetramer interface [polypeptide binding]; other site 710686013662 active site 710686013663 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686013664 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686013665 enoyl-CoA hydratase; Provisional; Region: PRK06688 710686013666 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686013667 substrate binding site [chemical binding]; other site 710686013668 oxyanion hole (OAH) forming residues; other site 710686013669 trimer interface [polypeptide binding]; other site 710686013670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 710686013671 H+ Antiporter protein; Region: 2A0121; TIGR00900 710686013672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013673 putative substrate translocation pore; other site 710686013674 CAAX protease self-immunity; Region: Abi; pfam02517 710686013675 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686013676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686013677 NAD(P) binding site [chemical binding]; other site 710686013678 active site 710686013679 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710686013680 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710686013681 trimer interface [polypeptide binding]; other site 710686013682 putative metal binding site [ion binding]; other site 710686013683 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 710686013684 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686013685 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 710686013686 NAD(P) binding site [chemical binding]; other site 710686013687 catalytic residues [active] 710686013688 oxidoreductase; Provisional; Region: PRK06196 710686013689 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710686013690 putative NAD(P) binding site [chemical binding]; other site 710686013691 active site 710686013692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013695 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710686013696 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686013697 conserved cys residue [active] 710686013698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686013699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686013700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686013701 putative substrate translocation pore; other site 710686013702 Fasciclin domain; Region: Fasciclin; pfam02469 710686013703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686013704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686013705 active site 710686013706 enoyl-CoA hydratase; Provisional; Region: PRK08252 710686013707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686013708 substrate binding site [chemical binding]; other site 710686013709 oxyanion hole (OAH) forming residues; other site 710686013710 trimer interface [polypeptide binding]; other site 710686013711 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710686013712 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686013713 dimer interface [polypeptide binding]; other site 710686013714 active site 710686013715 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710686013716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686013717 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710686013718 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 710686013719 Predicted membrane protein [Function unknown]; Region: COG2259 710686013720 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686013721 classical (c) SDRs; Region: SDR_c; cd05233 710686013722 NAD(P) binding site [chemical binding]; other site 710686013723 active site 710686013724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013726 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686013727 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686013728 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 710686013729 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710686013730 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686013731 classical (c) SDRs; Region: SDR_c; cd05233 710686013732 NAD(P) binding site [chemical binding]; other site 710686013733 active site 710686013734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686013735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013736 mce related protein; Region: MCE; pfam02470 710686013737 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013738 mce related protein; Region: MCE; pfam02470 710686013739 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686013740 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013741 mce related protein; Region: MCE; pfam02470 710686013742 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013743 mce related protein; Region: MCE; pfam02470 710686013744 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 710686013745 linker region; other site 710686013746 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013747 mce related protein; Region: MCE; pfam02470 710686013748 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686013749 mce related protein; Region: MCE; pfam02470 710686013750 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686013751 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686013752 Permease; Region: Permease; pfam02405 710686013753 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686013754 Permease; Region: Permease; pfam02405 710686013755 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 710686013756 dimer interface [polypeptide binding]; other site 710686013757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686013758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686013759 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686013760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686013761 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710686013762 hypothetical protein; Provisional; Region: PRK06149 710686013763 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710686013764 active site 710686013765 ATP binding site [chemical binding]; other site 710686013766 substrate binding site [chemical binding]; other site 710686013767 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686013768 inhibitor-cofactor binding pocket; inhibition site 710686013769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686013770 catalytic residue [active] 710686013771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686013772 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686013773 SnoaL-like domain; Region: SnoaL_3; pfam13474 710686013774 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686013775 cyclase homology domain; Region: CHD; cd07302 710686013776 nucleotidyl binding site; other site 710686013777 metal binding site [ion binding]; metal-binding site 710686013778 dimer interface [polypeptide binding]; other site 710686013779 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710686013780 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686013781 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686013782 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710686013783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686013784 S-adenosylmethionine binding site [chemical binding]; other site 710686013785 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686013786 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686013787 active site 710686013788 metal binding site [ion binding]; metal-binding site 710686013789 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 710686013790 GTP-binding protein YchF; Reviewed; Region: PRK09601 710686013791 YchF GTPase; Region: YchF; cd01900 710686013792 G1 box; other site 710686013793 GTP/Mg2+ binding site [chemical binding]; other site 710686013794 Switch I region; other site 710686013795 G2 box; other site 710686013796 Switch II region; other site 710686013797 G3 box; other site 710686013798 G4 box; other site 710686013799 G5 box; other site 710686013800 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 710686013801 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686013802 phosphopeptide binding site; other site 710686013803 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710686013804 metal ion-dependent adhesion site (MIDAS); other site 710686013805 Double zinc ribbon; Region: DZR; pfam12773 710686013806 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710686013807 Protein kinase domain; Region: Pkinase; pfam00069 710686013808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686013809 active site 710686013810 ATP binding site [chemical binding]; other site 710686013811 substrate binding site [chemical binding]; other site 710686013812 activation loop (A-loop); other site 710686013813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686013814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686013815 substrate binding pocket [chemical binding]; other site 710686013816 membrane-bound complex binding site; other site 710686013817 hinge residues; other site 710686013818 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710686013819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710686013820 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 710686013821 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 710686013822 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 710686013823 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 710686013824 generic binding surface II; other site 710686013825 generic binding surface I; other site 710686013826 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 710686013827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686013828 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 710686013829 NAD(P) binding site [chemical binding]; other site 710686013830 active site 710686013831 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 710686013832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686013833 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710686013834 Sulfatase; Region: Sulfatase; pfam00884 710686013835 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 710686013836 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710686013837 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 710686013838 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710686013839 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710686013840 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686013841 hydrophobic ligand binding site; other site 710686013842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686013843 classical (c) SDRs; Region: SDR_c; cd05233 710686013844 NAD(P) binding site [chemical binding]; other site 710686013845 active site 710686013846 short chain dehydrogenase; Provisional; Region: PRK07832 710686013847 classical (c) SDRs; Region: SDR_c; cd05233 710686013848 NAD(P) binding site [chemical binding]; other site 710686013849 active site 710686013850 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710686013851 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710686013852 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710686013853 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 710686013854 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 710686013855 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 710686013856 putative active site [active] 710686013857 fumarate hydratase; Reviewed; Region: fumC; PRK00485 710686013858 Class II fumarases; Region: Fumarase_classII; cd01362 710686013859 active site 710686013860 tetramer interface [polypeptide binding]; other site 710686013861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686013862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686013863 DNA binding residues [nucleotide binding] 710686013864 dimerization interface [polypeptide binding]; other site 710686013865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710686013866 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686013867 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710686013868 NodB motif; other site 710686013869 active site 710686013870 catalytic site [active] 710686013871 metal binding site [ion binding]; metal-binding site 710686013872 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 710686013873 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 710686013874 putative active site [active] 710686013875 PhoH-like protein; Region: PhoH; pfam02562 710686013876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710686013877 dinuclear metal binding motif [ion binding]; other site 710686013878 serine hydroxymethyltransferase; Provisional; Region: PRK13580 710686013879 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710686013880 dimer interface [polypeptide binding]; other site 710686013881 active site 710686013882 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710686013883 folate binding site [chemical binding]; other site 710686013884 pantothenate kinase; Provisional; Region: PRK05439 710686013885 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 710686013886 ATP-binding site [chemical binding]; other site 710686013887 CoA-binding site [chemical binding]; other site 710686013888 Mg2+-binding site [ion binding]; other site 710686013889 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710686013890 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 710686013891 catalytic residue [active] 710686013892 putative FPP diphosphate binding site; other site 710686013893 putative FPP binding hydrophobic cleft; other site 710686013894 dimer interface [polypeptide binding]; other site 710686013895 putative IPP diphosphate binding site; other site 710686013896 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 710686013897 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 710686013898 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686013899 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 710686013900 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 710686013901 catalytic residues [active] 710686013902 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 710686013903 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 710686013904 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710686013905 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710686013906 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710686013907 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 710686013908 cystathionine gamma-synthase; Provisional; Region: PRK07811 710686013909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710686013910 homodimer interface [polypeptide binding]; other site 710686013911 substrate-cofactor binding pocket; other site 710686013912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686013913 catalytic residue [active] 710686013914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686013915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686013916 active site 710686013917 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 710686013918 RDD family; Region: RDD; pfam06271 710686013919 RDD family; Region: RDD; pfam06271 710686013920 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 710686013921 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710686013922 dimer interface [polypeptide binding]; other site 710686013923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686013924 catalytic residue [active] 710686013925 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 710686013926 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710686013927 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686013928 substrate binding pocket [chemical binding]; other site 710686013929 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 710686013930 active site 710686013931 catalytic triad [active] 710686013932 oxyanion hole [active] 710686013933 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 710686013934 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686013935 dimer interface [polypeptide binding]; other site 710686013936 active site 710686013937 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710686013938 Bax inhibitor 1 like; Region: BaxI_1; cl17691 710686013939 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 710686013940 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686013941 substrate binding site [chemical binding]; other site 710686013942 oxyanion hole (OAH) forming residues; other site 710686013943 trimer interface [polypeptide binding]; other site 710686013944 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 710686013945 enoyl-CoA hydratase; Provisional; Region: PRK05862 710686013946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686013947 substrate binding site [chemical binding]; other site 710686013948 oxyanion hole (OAH) forming residues; other site 710686013949 trimer interface [polypeptide binding]; other site 710686013950 Predicted membrane protein [Function unknown]; Region: COG4425 710686013951 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710686013952 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710686013953 active site residue [active] 710686013954 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 710686013955 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710686013956 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 710686013957 active site 710686013958 nucleophile elbow; other site 710686013959 Patatin-like phospholipase; Region: Patatin; pfam01734 710686013960 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 710686013961 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 710686013962 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710686013963 putative active site [active] 710686013964 putative dimer interface [polypeptide binding]; other site 710686013965 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 710686013966 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686013967 putative NAD(P) binding site [chemical binding]; other site 710686013968 catalytic Zn binding site [ion binding]; other site 710686013969 structural Zn binding site [ion binding]; other site 710686013970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686013971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686013972 NAD(P) binding site [chemical binding]; other site 710686013973 active site 710686013974 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686013975 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686013976 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710686013977 DNA binding site [nucleotide binding] 710686013978 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710686013979 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686013980 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686013981 phosphopeptide binding site; other site 710686013982 lipid-transfer protein; Provisional; Region: PRK08256 710686013983 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686013984 active site 710686013985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 710686013986 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 710686013987 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 710686013988 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 710686013989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686013990 ATP binding site [chemical binding]; other site 710686013991 Mg2+ binding site [ion binding]; other site 710686013992 G-X-G motif; other site 710686013993 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710686013994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686013995 active site 710686013996 phosphorylation site [posttranslational modification] 710686013997 intermolecular recognition site; other site 710686013998 dimerization interface [polypeptide binding]; other site 710686013999 Homeodomain-like domain; Region: HTH_23; pfam13384 710686014000 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686014001 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 710686014002 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710686014003 PE-PPE domain; Region: PE-PPE; pfam08237 710686014004 Predicted esterase [General function prediction only]; Region: COG0627 710686014005 S-formylglutathione hydrolase; Region: PLN02442 710686014006 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710686014007 classical (c) SDRs; Region: SDR_c; cd05233 710686014008 NAD(P) binding site [chemical binding]; other site 710686014009 active site 710686014010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686014011 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710686014012 DNA-binding interface [nucleotide binding]; DNA binding site 710686014013 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686014014 Cytochrome P450; Region: p450; cl12078 710686014015 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710686014016 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710686014017 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686014018 catalytic residue [active] 710686014019 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710686014020 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710686014021 oligomer interface [polypeptide binding]; other site 710686014022 metal binding site [ion binding]; metal-binding site 710686014023 metal binding site [ion binding]; metal-binding site 710686014024 putative Cl binding site [ion binding]; other site 710686014025 basic sphincter; other site 710686014026 hydrophobic gate; other site 710686014027 periplasmic entrance; other site 710686014028 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 710686014029 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 710686014030 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 710686014031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686014032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710686014033 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710686014034 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710686014035 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 710686014036 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 710686014037 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 710686014038 Ligand Binding Site [chemical binding]; other site 710686014039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686014040 dimer interface [polypeptide binding]; other site 710686014041 phosphorylation site [posttranslational modification] 710686014042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686014043 ATP binding site [chemical binding]; other site 710686014044 Mg2+ binding site [ion binding]; other site 710686014045 G-X-G motif; other site 710686014046 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 710686014047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686014048 active site 710686014049 phosphorylation site [posttranslational modification] 710686014050 intermolecular recognition site; other site 710686014051 dimerization interface [polypeptide binding]; other site 710686014052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686014053 DNA binding site [nucleotide binding] 710686014054 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686014055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710686014056 MOSC domain; Region: MOSC; pfam03473 710686014057 3-alpha domain; Region: 3-alpha; pfam03475 710686014058 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 710686014059 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710686014060 FAD binding pocket [chemical binding]; other site 710686014061 FAD binding motif [chemical binding]; other site 710686014062 phosphate binding motif [ion binding]; other site 710686014063 beta-alpha-beta structure motif; other site 710686014064 NAD binding pocket [chemical binding]; other site 710686014065 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686014066 catalytic loop [active] 710686014067 iron binding site [ion binding]; other site 710686014068 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 710686014069 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686014070 hydrophobic ligand binding site; other site 710686014071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686014072 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710686014073 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 710686014074 acyl-activating enzyme (AAE) consensus motif; other site 710686014075 putative AMP binding site [chemical binding]; other site 710686014076 putative active site [active] 710686014077 putative CoA binding site [chemical binding]; other site 710686014078 PaaX-like protein; Region: PaaX; pfam07848 710686014079 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 710686014080 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686014081 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686014082 [2Fe-2S] cluster binding site [ion binding]; other site 710686014083 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 710686014084 putative alpha subunit interface [polypeptide binding]; other site 710686014085 putative active site [active] 710686014086 putative substrate binding site [chemical binding]; other site 710686014087 Fe binding site [ion binding]; other site 710686014088 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686014089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686014090 substrate binding site [chemical binding]; other site 710686014091 oxyanion hole (OAH) forming residues; other site 710686014092 trimer interface [polypeptide binding]; other site 710686014093 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 710686014094 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710686014095 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710686014096 Uncharacterized conserved protein [Function unknown]; Region: COG1507 710686014097 Septum formation initiator; Region: DivIC; pfam04977 710686014098 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 710686014099 enolase; Provisional; Region: eno; PRK00077 710686014100 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710686014101 dimer interface [polypeptide binding]; other site 710686014102 metal binding site [ion binding]; metal-binding site 710686014103 substrate binding pocket [chemical binding]; other site 710686014104 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710686014105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710686014106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710686014107 Iron permease FTR1 family; Region: FTR1; cl00475 710686014108 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 710686014109 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710686014110 Imelysin; Region: Peptidase_M75; pfam09375 710686014111 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710686014112 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 710686014113 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 710686014114 homodimer interface [polypeptide binding]; other site 710686014115 metal binding site [ion binding]; metal-binding site 710686014116 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 710686014117 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 710686014118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686014119 ATP binding site [chemical binding]; other site 710686014120 putative Mg++ binding site [ion binding]; other site 710686014121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686014122 nucleotide binding region [chemical binding]; other site 710686014123 ATP-binding site [chemical binding]; other site 710686014124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686014125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686014126 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 710686014127 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 710686014128 Substrate binding site; other site 710686014129 Mg++ binding site; other site 710686014130 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 710686014131 active site 710686014132 substrate binding site [chemical binding]; other site 710686014133 CoA binding site [chemical binding]; other site 710686014134 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710686014135 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 710686014136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686014137 active site 710686014138 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 710686014139 ArsC family; Region: ArsC; pfam03960 710686014140 catalytic residues [active] 710686014141 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710686014142 short chain dehydrogenase; Provisional; Region: PRK06197 710686014143 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710686014144 putative NAD(P) binding site [chemical binding]; other site 710686014145 active site 710686014146 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 710686014147 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 710686014148 5S rRNA interface [nucleotide binding]; other site 710686014149 CTC domain interface [polypeptide binding]; other site 710686014150 L16 interface [polypeptide binding]; other site 710686014151 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710686014152 putative active site [active] 710686014153 catalytic residue [active] 710686014154 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 710686014155 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710686014156 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 710686014157 4Fe-4S binding domain; Region: Fer4; pfam00037 710686014158 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686014159 classical (c) SDRs; Region: SDR_c; cd05233 710686014160 NAD(P) binding site [chemical binding]; other site 710686014161 active site 710686014162 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 710686014163 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686014164 active site 710686014165 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686014166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686014167 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710686014168 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686014169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686014170 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710686014171 Walker A/P-loop; other site 710686014172 ATP binding site [chemical binding]; other site 710686014173 Q-loop/lid; other site 710686014174 ABC transporter signature motif; other site 710686014175 Walker B; other site 710686014176 D-loop; other site 710686014177 H-loop/switch region; other site 710686014178 Lipase maturation factor; Region: LMF1; pfam06762 710686014179 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710686014180 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686014181 acyl-activating enzyme (AAE) consensus motif; other site 710686014182 active site 710686014183 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 710686014184 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 710686014185 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686014186 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686014187 active site 710686014188 ATP binding site [chemical binding]; other site 710686014189 substrate binding site [chemical binding]; other site 710686014190 activation loop (A-loop); other site 710686014191 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 710686014192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686014193 S-adenosylmethionine binding site [chemical binding]; other site 710686014194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 710686014195 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710686014196 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710686014197 G5 domain; Region: G5; pfam07501 710686014198 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710686014199 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710686014200 active site 710686014201 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 710686014202 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710686014203 active site 710686014204 HIGH motif; other site 710686014205 KMSKS motif; other site 710686014206 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710686014207 tRNA binding surface [nucleotide binding]; other site 710686014208 anticodon binding site; other site 710686014209 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686014210 active site 710686014211 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686014212 non-prolyl cis peptide bond; other site 710686014213 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686014214 active site 710686014215 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686014216 non-prolyl cis peptide bond; other site 710686014217 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 710686014218 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710686014219 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710686014220 dimerization interface [polypeptide binding]; other site 710686014221 active site 710686014222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686014223 putative substrate translocation pore; other site 710686014224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686014225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710686014226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686014227 dimer interface [polypeptide binding]; other site 710686014228 conserved gate region; other site 710686014229 putative PBP binding loops; other site 710686014230 ABC-ATPase subunit interface; other site 710686014231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710686014232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686014233 dimer interface [polypeptide binding]; other site 710686014234 conserved gate region; other site 710686014235 ABC-ATPase subunit interface; other site 710686014236 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686014237 active site 710686014238 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686014239 non-prolyl cis peptide bond; other site 710686014240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686014241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710686014242 Walker A/P-loop; other site 710686014243 ATP binding site [chemical binding]; other site 710686014244 Q-loop/lid; other site 710686014245 ABC transporter signature motif; other site 710686014246 Walker B; other site 710686014247 D-loop; other site 710686014248 H-loop/switch region; other site 710686014249 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686014250 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 710686014251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710686014252 Walker A/P-loop; other site 710686014253 ATP binding site [chemical binding]; other site 710686014254 Q-loop/lid; other site 710686014255 ABC transporter signature motif; other site 710686014256 Walker B; other site 710686014257 D-loop; other site 710686014258 H-loop/switch region; other site 710686014259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710686014260 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710686014261 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710686014262 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710686014263 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710686014264 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 710686014265 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710686014266 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710686014267 active site 710686014268 non-prolyl cis peptide bond; other site 710686014269 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710686014270 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710686014271 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710686014272 DNA binding residues [nucleotide binding] 710686014273 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686014274 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 710686014275 chorismate binding enzyme; Region: Chorismate_bind; cl10555 710686014276 Predicted methyltransferases [General function prediction only]; Region: COG0313 710686014277 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 710686014278 putative SAM binding site [chemical binding]; other site 710686014279 putative homodimer interface [polypeptide binding]; other site 710686014280 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710686014281 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710686014282 arginine deiminase; Provisional; Region: PRK01388 710686014283 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 710686014284 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 710686014285 DNA binding residues [nucleotide binding] 710686014286 dimer interface [polypeptide binding]; other site 710686014287 [2Fe-2S] cluster binding site [ion binding]; other site 710686014288 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 710686014289 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710686014290 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 710686014291 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710686014292 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710686014293 shikimate binding site; other site 710686014294 NAD(P) binding site [chemical binding]; other site 710686014295 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686014296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686014297 ligand binding site [chemical binding]; other site 710686014298 flexible hinge region; other site 710686014299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710686014300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686014301 Coenzyme A binding pocket [chemical binding]; other site 710686014302 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686014303 catalytic residues [active] 710686014304 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686014305 E3 interaction surface; other site 710686014306 lipoyl attachment site [posttranslational modification]; other site 710686014307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686014308 carboxyltransferase (CT) interaction site; other site 710686014309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710686014310 E3 interaction surface; other site 710686014311 lipoyl attachment site [posttranslational modification]; other site 710686014312 patatin-related protein; Region: TIGR03607 710686014313 Patatin-like phospholipase; Region: Patatin; pfam01734 710686014314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686014315 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710686014316 cyclase homology domain; Region: CHD; cd07302 710686014317 nucleotidyl binding site; other site 710686014318 metal binding site [ion binding]; metal-binding site 710686014319 dimer interface [polypeptide binding]; other site 710686014320 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710686014321 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686014322 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710686014323 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710686014324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686014325 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686014326 cyclase homology domain; Region: CHD; cd07302 710686014327 nucleotidyl binding site; other site 710686014328 metal binding site [ion binding]; metal-binding site 710686014329 dimer interface [polypeptide binding]; other site 710686014330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686014331 dimerization interface [polypeptide binding]; other site 710686014332 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686014333 cyclase homology domain; Region: CHD; cd07302 710686014334 nucleotidyl binding site; other site 710686014335 metal binding site [ion binding]; metal-binding site 710686014336 dimer interface [polypeptide binding]; other site 710686014337 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686014338 cyclase homology domain; Region: CHD; cd07302 710686014339 AAA ATPase domain; Region: AAA_16; pfam13191 710686014340 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686014341 Helix-turn-helix domain; Region: HTH_17; cl17695 710686014342 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710686014343 Ligand Binding Site [chemical binding]; other site 710686014344 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686014345 cyclase homology domain; Region: CHD; cd07302 710686014346 nucleotidyl binding site; other site 710686014347 metal binding site [ion binding]; metal-binding site 710686014348 dimer interface [polypeptide binding]; other site 710686014349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 710686014350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710686014351 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710686014352 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710686014353 dimer interface [polypeptide binding]; other site 710686014354 putative functional site; other site 710686014355 putative MPT binding site; other site 710686014356 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 710686014357 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 710686014358 active site 710686014359 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 710686014360 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 710686014361 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 710686014362 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 710686014363 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 710686014364 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 710686014365 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 710686014366 MspA; Region: MspA; pfam09203 710686014367 MspA; Region: MspA; pfam09203 710686014368 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710686014369 MPT binding site; other site 710686014370 trimer interface [polypeptide binding]; other site 710686014371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686014372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710686014373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686014374 dimerization interface [polypeptide binding]; other site 710686014375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686014376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686014377 dimer interface [polypeptide binding]; other site 710686014378 phosphorylation site [posttranslational modification] 710686014379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686014380 ATP binding site [chemical binding]; other site 710686014381 Mg2+ binding site [ion binding]; other site 710686014382 G-X-G motif; other site 710686014383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686014384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686014385 active site 710686014386 phosphorylation site [posttranslational modification] 710686014387 intermolecular recognition site; other site 710686014388 dimerization interface [polypeptide binding]; other site 710686014389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686014390 DNA binding site [nucleotide binding] 710686014391 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 710686014392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686014393 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686014394 active site 710686014395 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710686014396 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686014397 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710686014398 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710686014399 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710686014400 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710686014401 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710686014402 carboxyltransferase (CT) interaction site; other site 710686014403 biotinylation site [posttranslational modification]; other site 710686014404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686014405 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686014406 active site 710686014407 enoyl-CoA hydratase; Provisional; Region: PRK07827 710686014408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686014409 substrate binding site [chemical binding]; other site 710686014410 oxyanion hole (OAH) forming residues; other site 710686014411 trimer interface [polypeptide binding]; other site 710686014412 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 710686014413 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710686014414 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 710686014415 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 710686014416 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710686014417 metal ion-dependent adhesion site (MIDAS); other site 710686014418 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 710686014419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710686014420 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 710686014421 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 710686014422 purine monophosphate binding site [chemical binding]; other site 710686014423 dimer interface [polypeptide binding]; other site 710686014424 putative catalytic residues [active] 710686014425 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 710686014426 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 710686014427 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 710686014428 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 710686014429 active site 710686014430 substrate binding site [chemical binding]; other site 710686014431 cosubstrate binding site; other site 710686014432 catalytic site [active] 710686014433 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 710686014434 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 710686014435 active site 710686014436 dimer interface [polypeptide binding]; other site 710686014437 non-prolyl cis peptide bond; other site 710686014438 insertion regions; other site 710686014439 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 710686014440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 710686014441 dimer interface [polypeptide binding]; other site 710686014442 active site 710686014443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686014444 catalytic residues [active] 710686014445 substrate binding site [chemical binding]; other site 710686014446 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686014447 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686014448 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710686014449 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686014450 active site 710686014451 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 710686014452 CoA binding domain; Region: CoA_binding; smart00881 710686014453 CoA-ligase; Region: Ligase_CoA; pfam00549 710686014454 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 710686014455 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 710686014456 CoA-ligase; Region: Ligase_CoA; pfam00549 710686014457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710686014458 Peptidase family M23; Region: Peptidase_M23; pfam01551 710686014459 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710686014460 Part of AAA domain; Region: AAA_19; pfam13245 710686014461 Family description; Region: UvrD_C_2; pfam13538 710686014462 hypothetical protein; Provisional; Region: PRK07857 710686014463 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710686014464 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710686014465 active site 710686014466 catalytic triad [active] 710686014467 oxyanion hole [active] 710686014468 succinic semialdehyde dehydrogenase; Region: PLN02278 710686014469 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710686014470 tetramerization interface [polypeptide binding]; other site 710686014471 NAD(P) binding site [chemical binding]; other site 710686014472 catalytic residues [active] 710686014473 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 710686014474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 710686014475 active site 710686014476 dimer interface [polypeptide binding]; other site 710686014477 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 710686014478 dimer interface [polypeptide binding]; other site 710686014479 active site 710686014480 short chain dehydrogenase; Provisional; Region: PRK08251 710686014481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686014482 NAD(P) binding site [chemical binding]; other site 710686014483 active site 710686014484 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710686014485 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 710686014486 putative DNA binding site [nucleotide binding]; other site 710686014487 catalytic residue [active] 710686014488 putative H2TH interface [polypeptide binding]; other site 710686014489 putative catalytic residues [active] 710686014490 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710686014491 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710686014492 Predicted membrane protein [Function unknown]; Region: COG1950 710686014493 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 710686014494 active site 710686014495 SAM binding site [chemical binding]; other site 710686014496 homodimer interface [polypeptide binding]; other site 710686014497 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710686014498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686014499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686014500 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 710686014501 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686014502 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686014503 CheB methylesterase; Region: CheB_methylest; pfam01339 710686014504 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686014505 anti sigma factor interaction site; other site 710686014506 regulatory phosphorylation site [posttranslational modification]; other site 710686014507 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710686014508 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 710686014509 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 710686014510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686014511 S-adenosylmethionine binding site [chemical binding]; other site 710686014512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686014513 PAS domain; Region: PAS_9; pfam13426 710686014514 putative active site [active] 710686014515 heme pocket [chemical binding]; other site 710686014516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686014517 PAS domain; Region: PAS_9; pfam13426 710686014518 putative active site [active] 710686014519 heme pocket [chemical binding]; other site 710686014520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686014521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686014522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686014523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686014524 NAD(P) binding site [chemical binding]; other site 710686014525 active site 710686014526 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 710686014527 homodimer interaction site [polypeptide binding]; other site 710686014528 cofactor binding site; other site 710686014529 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686014530 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686014531 phosphopeptide binding site; other site 710686014532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686014533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710686014534 DNA binding residues [nucleotide binding] 710686014535 dimerization interface [polypeptide binding]; other site 710686014536 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686014537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686014538 active site 710686014539 ATP binding site [chemical binding]; other site 710686014540 substrate binding site [chemical binding]; other site 710686014541 activation loop (A-loop); other site 710686014542 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 710686014543 Kelch domain; Region: Kelch; smart00612 710686014544 Kelch motif; Region: Kelch_1; pfam01344 710686014545 Kelch domain; Region: Kelch; smart00612 710686014546 Galactose oxidase, central domain; Region: Kelch_3; cl02701 710686014547 Kelch domain; Region: Kelch; smart00612 710686014548 Kelch motif; Region: Kelch_1; pfam01344 710686014549 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710686014550 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 710686014551 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 710686014552 nucleotide binding site [chemical binding]; other site 710686014553 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 710686014554 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710686014555 active site 710686014556 DNA binding site [nucleotide binding] 710686014557 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710686014558 DNA binding site [nucleotide binding] 710686014559 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 710686014560 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 710686014561 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710686014562 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710686014563 Walker A/P-loop; other site 710686014564 ATP binding site [chemical binding]; other site 710686014565 Q-loop/lid; other site 710686014566 ABC transporter signature motif; other site 710686014567 Walker B; other site 710686014568 D-loop; other site 710686014569 H-loop/switch region; other site 710686014570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710686014571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686014572 dimer interface [polypeptide binding]; other site 710686014573 conserved gate region; other site 710686014574 putative PBP binding loops; other site 710686014575 ABC-ATPase subunit interface; other site 710686014576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686014577 dimer interface [polypeptide binding]; other site 710686014578 putative PBP binding loops; other site 710686014579 ABC-ATPase subunit interface; other site 710686014580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710686014581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710686014582 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 710686014583 MarR family; Region: MarR_2; pfam12802 710686014584 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 710686014585 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686014586 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 710686014587 inhibitor binding site; inhibition site 710686014588 catalytic Zn binding site [ion binding]; other site 710686014589 structural Zn binding site [ion binding]; other site 710686014590 NADP binding site [chemical binding]; other site 710686014591 tetramer interface [polypeptide binding]; other site 710686014592 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 710686014593 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 710686014594 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 710686014595 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 710686014596 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710686014597 putative substrate binding site [chemical binding]; other site 710686014598 putative ATP binding site [chemical binding]; other site 710686014599 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 710686014600 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 710686014601 putative DNA binding site [nucleotide binding]; other site 710686014602 putative homodimer interface [polypeptide binding]; other site 710686014603 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710686014604 short chain dehydrogenase; Provisional; Region: PRK07814 710686014605 classical (c) SDRs; Region: SDR_c; cd05233 710686014606 NAD(P) binding site [chemical binding]; other site 710686014607 active site 710686014608 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686014609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686014610 manganese transport protein MntH; Reviewed; Region: PRK00701 710686014611 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710686014612 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710686014613 putative active site pocket [active] 710686014614 dimerization interface [polypeptide binding]; other site 710686014615 putative catalytic residue [active] 710686014616 Protein of unknown function (DUF867); Region: DUF867; pfam05908 710686014617 amino acid transporter; Region: 2A0306; TIGR00909 710686014618 amino acid transporter; Region: 2A0306; TIGR00909 710686014619 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710686014620 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710686014621 active site 710686014622 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 710686014623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686014624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686014625 DNA binding residues [nucleotide binding] 710686014626 Anti-sigma-K factor rskA; Region: RskA; pfam10099 710686014627 carboxylate-amine ligase; Provisional; Region: PRK13517 710686014628 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710686014629 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 710686014630 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686014631 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686014632 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710686014633 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686014634 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686014635 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686014636 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686014637 MspA; Region: MspA; pfam09203 710686014638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686014639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686014640 active site 710686014641 phosphorylation site [posttranslational modification] 710686014642 intermolecular recognition site; other site 710686014643 dimerization interface [polypeptide binding]; other site 710686014644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686014645 DNA binding site [nucleotide binding] 710686014646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686014647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686014648 dimerization interface [polypeptide binding]; other site 710686014649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686014650 dimer interface [polypeptide binding]; other site 710686014651 phosphorylation site [posttranslational modification] 710686014652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686014653 ATP binding site [chemical binding]; other site 710686014654 Mg2+ binding site [ion binding]; other site 710686014655 G-X-G motif; other site 710686014656 Putative esterase; Region: Esterase; pfam00756 710686014657 ANTAR domain; Region: ANTAR; pfam03861 710686014658 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 710686014659 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686014660 active site 710686014661 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710686014662 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710686014663 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686014664 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686014665 Predicted transcriptional regulators [Transcription]; Region: COG1733 710686014666 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710686014667 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710686014668 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710686014669 putative dimer interface [polypeptide binding]; other site 710686014670 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710686014671 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710686014672 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 710686014673 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 710686014674 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 710686014675 TrkA-N domain; Region: TrkA_N; pfam02254 710686014676 Ion channel; Region: Ion_trans_2; pfam07885 710686014677 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710686014678 TrkA-N domain; Region: TrkA_N; pfam02254 710686014679 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710686014680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686014681 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710686014682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686014683 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 710686014684 active site 710686014685 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 710686014686 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686014687 NAD binding site [chemical binding]; other site 710686014688 catalytic residues [active] 710686014689 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710686014690 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710686014691 PYR/PP interface [polypeptide binding]; other site 710686014692 dimer interface [polypeptide binding]; other site 710686014693 TPP binding site [chemical binding]; other site 710686014694 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686014695 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710686014696 TPP-binding site; other site 710686014697 dimer interface [polypeptide binding]; other site 710686014698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686014699 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686014700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686014701 active site 710686014702 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710686014703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686014704 active site 710686014705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686014706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686014707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686014708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686014709 active site 710686014710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686014711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686014712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686014713 NAD(P) binding site [chemical binding]; other site 710686014714 active site 710686014715 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686014716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686014717 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686014718 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686014719 [2Fe-2S] cluster binding site [ion binding]; other site 710686014720 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 710686014721 putative alpha subunit interface [polypeptide binding]; other site 710686014722 putative active site [active] 710686014723 putative substrate binding site [chemical binding]; other site 710686014724 Fe binding site [ion binding]; other site 710686014725 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710686014726 classical (c) SDRs; Region: SDR_c; cd05233 710686014727 NAD(P) binding site [chemical binding]; other site 710686014728 active site 710686014729 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710686014730 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710686014731 structural tetrad; other site 710686014732 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710686014733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686014734 DNA-binding site [nucleotide binding]; DNA binding site 710686014735 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710686014736 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 710686014737 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710686014738 acyl-activating enzyme (AAE) consensus motif; other site 710686014739 putative AMP binding site [chemical binding]; other site 710686014740 putative active site [active] 710686014741 putative CoA binding site [chemical binding]; other site 710686014742 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710686014743 classical (c) SDRs; Region: SDR_c; cd05233 710686014744 NAD(P) binding site [chemical binding]; other site 710686014745 active site 710686014746 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710686014747 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686014748 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710686014749 acyl-activating enzyme (AAE) consensus motif; other site 710686014750 acyl-activating enzyme (AAE) consensus motif; other site 710686014751 putative AMP binding site [chemical binding]; other site 710686014752 putative active site [active] 710686014753 putative CoA binding site [chemical binding]; other site 710686014754 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 710686014755 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710686014756 NAD(P) binding site [chemical binding]; other site 710686014757 putative active site [active] 710686014758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686014759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686014760 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710686014761 metal ion-dependent adhesion site (MIDAS); other site 710686014762 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710686014763 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 710686014764 Walker A motif; other site 710686014765 ATP binding site [chemical binding]; other site 710686014766 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710686014767 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686014768 hydrophobic ligand binding site; other site 710686014769 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710686014770 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710686014771 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686014772 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710686014773 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686014774 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686014775 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 710686014776 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710686014777 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710686014778 enoyl-CoA hydratase; Provisional; Region: PRK06688 710686014779 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686014780 substrate binding site [chemical binding]; other site 710686014781 oxyanion hole (OAH) forming residues; other site 710686014782 trimer interface [polypeptide binding]; other site 710686014783 Predicted esterase [General function prediction only]; Region: COG0627 710686014784 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710686014785 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 710686014786 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686014787 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710686014788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686014789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686014790 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710686014791 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686014792 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686014793 tyramine oxidase; Provisional; Region: tynA; PRK11504 710686014794 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 710686014795 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 710686014796 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 710686014797 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686014798 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686014799 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710686014800 NAD(P) binding site [chemical binding]; other site 710686014801 catalytic residues [active] 710686014802 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710686014803 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710686014804 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 710686014805 Bacterial transcriptional regulator; Region: IclR; pfam01614 710686014806 AMP-binding domain protein; Validated; Region: PRK08315 710686014807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686014808 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710686014809 acyl-activating enzyme (AAE) consensus motif; other site 710686014810 acyl-activating enzyme (AAE) consensus motif; other site 710686014811 putative AMP binding site [chemical binding]; other site 710686014812 putative active site [active] 710686014813 putative CoA binding site [chemical binding]; other site 710686014814 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 710686014815 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686014816 acyl-activating enzyme (AAE) consensus motif; other site 710686014817 AMP binding site [chemical binding]; other site 710686014818 active site 710686014819 CoA binding site [chemical binding]; other site 710686014820 GAF domain; Region: GAF; cl17456 710686014821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686014822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686014823 DNA binding residues [nucleotide binding] 710686014824 dimerization interface [polypeptide binding]; other site 710686014825 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710686014826 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710686014827 putative dimer interface [polypeptide binding]; other site 710686014828 Epoxide hydrolase N terminus; Region: EHN; pfam06441 710686014829 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686014830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686014831 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710686014832 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686014833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686014834 Walker A/P-loop; other site 710686014835 ATP binding site [chemical binding]; other site 710686014836 Q-loop/lid; other site 710686014837 ABC transporter signature motif; other site 710686014838 Walker B; other site 710686014839 D-loop; other site 710686014840 H-loop/switch region; other site 710686014841 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710686014842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710686014843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686014844 Walker A/P-loop; other site 710686014845 ATP binding site [chemical binding]; other site 710686014846 Q-loop/lid; other site 710686014847 ABC transporter signature motif; other site 710686014848 Walker B; other site 710686014849 D-loop; other site 710686014850 H-loop/switch region; other site 710686014851 Chromate transporter; Region: Chromate_transp; pfam02417 710686014852 Chromate transporter; Region: Chromate_transp; pfam02417 710686014853 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 710686014854 PLD-like domain; Region: PLDc_2; pfam13091 710686014855 putative active site [active] 710686014856 putative catalytic site [active] 710686014857 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 710686014858 PLD-like domain; Region: PLDc_2; pfam13091 710686014859 putative active site [active] 710686014860 putative catalytic site [active] 710686014861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686014862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686014863 active site 710686014864 phosphorylation site [posttranslational modification] 710686014865 intermolecular recognition site; other site 710686014866 dimerization interface [polypeptide binding]; other site 710686014867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686014868 DNA binding site [nucleotide binding] 710686014869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686014870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686014871 dimerization interface [polypeptide binding]; other site 710686014872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686014873 dimer interface [polypeptide binding]; other site 710686014874 phosphorylation site [posttranslational modification] 710686014875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686014876 ATP binding site [chemical binding]; other site 710686014877 Mg2+ binding site [ion binding]; other site 710686014878 G-X-G motif; other site 710686014879 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710686014880 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 710686014881 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710686014882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686014883 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686014884 Double zinc ribbon; Region: DZR; pfam12773 710686014885 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686014886 cyclase homology domain; Region: CHD; cd07302 710686014887 nucleotidyl binding site; other site 710686014888 metal binding site [ion binding]; metal-binding site 710686014889 dimer interface [polypeptide binding]; other site 710686014890 Predicted ATPase [General function prediction only]; Region: COG3899 710686014891 AAA ATPase domain; Region: AAA_16; pfam13191 710686014892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686014893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710686014894 putative DNA binding site [nucleotide binding]; other site 710686014895 dimerization interface [polypeptide binding]; other site 710686014896 putative Zn2+ binding site [ion binding]; other site 710686014897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710686014898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686014899 putative substrate translocation pore; other site 710686014900 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 710686014901 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710686014902 dimer interface [polypeptide binding]; other site 710686014903 active site 710686014904 citrylCoA binding site [chemical binding]; other site 710686014905 NADH binding [chemical binding]; other site 710686014906 cationic pore residues; other site 710686014907 oxalacetate/citrate binding site [chemical binding]; other site 710686014908 coenzyme A binding site [chemical binding]; other site 710686014909 catalytic triad [active] 710686014910 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710686014911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686014912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686014913 putative substrate translocation pore; other site 710686014914 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 710686014915 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710686014916 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 710686014917 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 710686014918 dimer interface [polypeptide binding]; other site 710686014919 Citrate synthase; Region: Citrate_synt; pfam00285 710686014920 active site 710686014921 citrylCoA binding site [chemical binding]; other site 710686014922 oxalacetate/citrate binding site [chemical binding]; other site 710686014923 coenzyme A binding site [chemical binding]; other site 710686014924 catalytic triad [active] 710686014925 TIGR03086 family protein; Region: TIGR03086 710686014926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710686014927 putative dimer interface [polypeptide binding]; other site 710686014928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686014929 TM2 domain; Region: TM2; pfam05154 710686014930 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710686014931 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710686014932 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 710686014933 AAA ATPase domain; Region: AAA_16; pfam13191 710686014934 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710686014935 Ferredoxin [Energy production and conversion]; Region: COG1146 710686014936 4Fe-4S binding domain; Region: Fer4; pfam00037 710686014937 ferredoxin-NADP+ reductase; Region: PLN02852 710686014938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686014939 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710686014940 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710686014941 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686014942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686014943 catalytic residue [active] 710686014944 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 710686014945 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710686014946 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710686014947 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 710686014948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686014949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686014950 DNA binding residues [nucleotide binding] 710686014951 dimerization interface [polypeptide binding]; other site 710686014952 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710686014953 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710686014954 MarR family; Region: MarR; pfam01047 710686014955 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 710686014956 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 710686014957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686014958 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 710686014959 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 710686014960 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 710686014961 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 710686014962 putative dimer interface [polypeptide binding]; other site 710686014963 N-terminal domain interface [polypeptide binding]; other site 710686014964 putative substrate binding pocket (H-site) [chemical binding]; other site 710686014965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710686014966 DNA-binding site [nucleotide binding]; DNA binding site 710686014967 RNA-binding motif; other site 710686014968 hypothetical protein; Provisional; Region: PRK11770 710686014969 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710686014970 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710686014971 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 710686014972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686014973 FeS/SAM binding site; other site 710686014974 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 710686014975 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 710686014976 MoaE interaction surface [polypeptide binding]; other site 710686014977 MoeB interaction surface [polypeptide binding]; other site 710686014978 thiocarboxylated glycine; other site 710686014979 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710686014980 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 710686014981 MoaE homodimer interface [polypeptide binding]; other site 710686014982 MoaD interaction [polypeptide binding]; other site 710686014983 active site residues [active] 710686014984 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710686014985 MPT binding site; other site 710686014986 trimer interface [polypeptide binding]; other site 710686014987 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 710686014988 trimer interface [polypeptide binding]; other site 710686014989 dimer interface [polypeptide binding]; other site 710686014990 putative active site [active] 710686014991 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710686014992 WYL domain; Region: WYL; pfam13280 710686014993 Predicted esterase [General function prediction only]; Region: COG0627 710686014994 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710686014995 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710686014996 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 710686014997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686014998 ATP binding site [chemical binding]; other site 710686014999 putative Mg++ binding site [ion binding]; other site 710686015000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686015001 nucleotide binding region [chemical binding]; other site 710686015002 ATP-binding site [chemical binding]; other site 710686015003 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686015004 Cupin domain; Region: Cupin_2; cl17218 710686015005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015006 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686015007 NAD(P) binding site [chemical binding]; other site 710686015008 active site 710686015009 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710686015010 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686015011 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686015012 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 710686015013 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 710686015014 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710686015015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686015016 S-adenosylmethionine binding site [chemical binding]; other site 710686015017 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686015018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686015019 acyl-activating enzyme (AAE) consensus motif; other site 710686015020 AMP binding site [chemical binding]; other site 710686015021 active site 710686015022 CoA binding site [chemical binding]; other site 710686015023 alpha-galactosidase; Region: PLN02808; cl17638 710686015024 Lipase (class 2); Region: Lipase_2; pfam01674 710686015025 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686015026 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 710686015027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686015028 substrate binding site [chemical binding]; other site 710686015029 oxyanion hole (OAH) forming residues; other site 710686015030 trimer interface [polypeptide binding]; other site 710686015031 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710686015032 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710686015033 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 710686015034 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686015035 dimer interface [polypeptide binding]; other site 710686015036 active site 710686015037 Helix-turn-helix domain; Region: HTH_38; pfam13936 710686015038 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710686015039 Integrase core domain; Region: rve; pfam00665 710686015040 aminotransferase; Validated; Region: PRK07777 710686015041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686015042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686015043 homodimer interface [polypeptide binding]; other site 710686015044 catalytic residue [active] 710686015045 PE-PPE domain; Region: PE-PPE; pfam08237 710686015046 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710686015047 putative hydrophobic ligand binding site [chemical binding]; other site 710686015048 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710686015049 putative hydrophobic ligand binding site [chemical binding]; other site 710686015050 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710686015051 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710686015052 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686015053 Double zinc ribbon; Region: DZR; pfam12773 710686015054 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015055 cyclase homology domain; Region: CHD; cd07302 710686015056 nucleotidyl binding site; other site 710686015057 metal binding site [ion binding]; metal-binding site 710686015058 dimer interface [polypeptide binding]; other site 710686015059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686015060 S-adenosylmethionine binding site [chemical binding]; other site 710686015061 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686015062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686015063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686015064 S-adenosylmethionine binding site [chemical binding]; other site 710686015065 Cytochrome P450; Region: p450; cl12078 710686015066 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 710686015067 short chain dehydrogenase; Provisional; Region: PRK06914 710686015068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015069 NAD(P) binding site [chemical binding]; other site 710686015070 active site 710686015071 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686015072 hypothetical protein; Provisional; Region: PRK06753 710686015073 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686015074 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686015075 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686015076 acyl-activating enzyme (AAE) consensus motif; other site 710686015077 AMP binding site [chemical binding]; other site 710686015078 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686015079 Condensation domain; Region: Condensation; pfam00668 710686015080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686015081 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686015082 acyl-activating enzyme (AAE) consensus motif; other site 710686015083 AMP binding site [chemical binding]; other site 710686015084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686015085 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 710686015086 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710686015087 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686015088 active site 710686015089 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686015090 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710686015091 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 710686015092 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 710686015093 Enoylreductase; Region: PKS_ER; smart00829 710686015094 NAD(P) binding site [chemical binding]; other site 710686015095 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 710686015096 putative NADP binding site [chemical binding]; other site 710686015097 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710686015098 active site 710686015099 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686015100 Condensation domain; Region: Condensation; pfam00668 710686015101 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710686015102 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686015103 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015104 cyclase homology domain; Region: CHD; cd07302 710686015105 nucleotidyl binding site; other site 710686015106 metal binding site [ion binding]; metal-binding site 710686015107 dimer interface [polypeptide binding]; other site 710686015108 Predicted ATPase [General function prediction only]; Region: COG3899 710686015109 AAA ATPase domain; Region: AAA_16; pfam13191 710686015110 Double zinc ribbon; Region: DZR; pfam12773 710686015111 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686015112 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015113 cyclase homology domain; Region: CHD; cd07302 710686015114 nucleotidyl binding site; other site 710686015115 metal binding site [ion binding]; metal-binding site 710686015116 dimer interface [polypeptide binding]; other site 710686015117 Predicted ATPase [General function prediction only]; Region: COG3899 710686015118 AAA ATPase domain; Region: AAA_16; pfam13191 710686015119 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686015120 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015121 cyclase homology domain; Region: CHD; cd07302 710686015122 nucleotidyl binding site; other site 710686015123 metal binding site [ion binding]; metal-binding site 710686015124 dimer interface [polypeptide binding]; other site 710686015125 Double zinc ribbon; Region: DZR; pfam12773 710686015126 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710686015127 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015128 cyclase homology domain; Region: CHD; cd07302 710686015129 nucleotidyl binding site; other site 710686015130 metal binding site [ion binding]; metal-binding site 710686015131 dimer interface [polypeptide binding]; other site 710686015132 Predicted ATPase [General function prediction only]; Region: COG3899 710686015133 AAA ATPase domain; Region: AAA_16; pfam13191 710686015134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686015136 DNA binding residues [nucleotide binding] 710686015137 dimerization interface [polypeptide binding]; other site 710686015138 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710686015139 putative hydrophobic ligand binding site [chemical binding]; other site 710686015140 SnoaL-like domain; Region: SnoaL_4; pfam13577 710686015141 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015142 mce related protein; Region: MCE; pfam02470 710686015143 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015144 mce related protein; Region: MCE; pfam02470 710686015145 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686015146 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015147 mce related protein; Region: MCE; pfam02470 710686015148 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015149 mce related protein; Region: MCE; pfam02470 710686015150 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015151 mce related protein; Region: MCE; pfam02470 710686015152 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015153 mce related protein; Region: MCE; pfam02470 710686015154 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686015155 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686015156 Permease; Region: Permease; pfam02405 710686015157 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686015158 Permease; Region: Permease; pfam02405 710686015159 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710686015160 Cation efflux family; Region: Cation_efflux; cl00316 710686015161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015162 NAD(P) binding site [chemical binding]; other site 710686015163 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686015164 active site 710686015165 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710686015166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686015167 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710686015168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015169 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710686015170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 710686015171 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710686015172 putative hydrophobic ligand binding site [chemical binding]; other site 710686015173 protein interface [polypeptide binding]; other site 710686015174 gate; other site 710686015175 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686015176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015177 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 710686015178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686015179 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686015180 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686015181 active site 710686015182 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686015183 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710686015184 NAD(P) binding site [chemical binding]; other site 710686015185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015186 short chain dehydrogenase; Provisional; Region: PRK05650 710686015187 NAD(P) binding site [chemical binding]; other site 710686015188 active site 710686015189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686015190 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686015191 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686015192 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015193 Cytochrome P450; Region: p450; cl12078 710686015194 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686015195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686015196 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686015197 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710686015198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710686015201 Histidine kinase; Region: HisKA_3; pfam07730 710686015202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686015203 ATP binding site [chemical binding]; other site 710686015204 Mg2+ binding site [ion binding]; other site 710686015205 G-X-G motif; other site 710686015206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015208 active site 710686015209 phosphorylation site [posttranslational modification] 710686015210 intermolecular recognition site; other site 710686015211 dimerization interface [polypeptide binding]; other site 710686015212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015214 active site 710686015215 phosphorylation site [posttranslational modification] 710686015216 intermolecular recognition site; other site 710686015217 dimerization interface [polypeptide binding]; other site 710686015218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686015219 DNA binding residues [nucleotide binding] 710686015220 dimerization interface [polypeptide binding]; other site 710686015221 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 710686015222 nucleophile elbow; other site 710686015223 Gas vesicle protein K; Region: GvpK; pfam05121 710686015224 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 710686015225 Gas vesicle protein; Region: Gas_vesicle; pfam00741 710686015226 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 710686015227 Gas vesicle protein G; Region: GvpG; pfam05120 710686015228 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 710686015229 Gas vesicle protein; Region: Gas_vesicle; cl02954 710686015230 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 710686015231 putative hydrophobic ligand binding site [chemical binding]; other site 710686015232 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710686015233 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686015234 H+ Antiporter protein; Region: 2A0121; TIGR00900 710686015235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686015236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686015237 active site 710686015238 ATP binding site [chemical binding]; other site 710686015239 substrate binding site [chemical binding]; other site 710686015240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686015241 substrate binding site [chemical binding]; other site 710686015242 activation loop (A-loop); other site 710686015243 activation loop (A-loop); other site 710686015244 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710686015245 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710686015246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015247 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 710686015248 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 710686015249 homodimer interface [polypeptide binding]; other site 710686015250 putative substrate binding pocket [chemical binding]; other site 710686015251 diiron center [ion binding]; other site 710686015252 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 710686015253 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 710686015254 FMN binding site [chemical binding]; other site 710686015255 active site 710686015256 catalytic residues [active] 710686015257 substrate binding site [chemical binding]; other site 710686015258 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710686015259 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710686015260 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710686015261 PhoU domain; Region: PhoU; pfam01895 710686015262 PhoU domain; Region: PhoU; pfam01895 710686015263 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710686015264 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710686015265 putative NAD(P) binding site [chemical binding]; other site 710686015266 hypothetical protein; Provisional; Region: PRK08204 710686015267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686015268 active site 710686015269 hypothetical protein; Provisional; Region: PRK06184 710686015270 hypothetical protein; Provisional; Region: PRK07236 710686015271 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686015272 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710686015273 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686015274 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686015275 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710686015276 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 710686015277 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 710686015278 Walker A/P-loop; other site 710686015279 ATP binding site [chemical binding]; other site 710686015280 Q-loop/lid; other site 710686015281 ABC transporter signature motif; other site 710686015282 Walker B; other site 710686015283 D-loop; other site 710686015284 H-loop/switch region; other site 710686015285 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 710686015286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686015287 dimer interface [polypeptide binding]; other site 710686015288 conserved gate region; other site 710686015289 putative PBP binding loops; other site 710686015290 ABC-ATPase subunit interface; other site 710686015291 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 710686015292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686015293 dimer interface [polypeptide binding]; other site 710686015294 conserved gate region; other site 710686015295 putative PBP binding loops; other site 710686015296 ABC-ATPase subunit interface; other site 710686015297 PBP superfamily domain; Region: PBP_like_2; cl17296 710686015298 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 710686015299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710686015300 Coenzyme A binding pocket [chemical binding]; other site 710686015301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710686015302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686015303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686015304 DNA binding site [nucleotide binding] 710686015305 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710686015306 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686015307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686015308 catalytic residues [active] 710686015309 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 710686015310 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710686015311 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710686015312 active site residue [active] 710686015313 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710686015314 active site residue [active] 710686015315 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 710686015316 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710686015317 heme-binding site [chemical binding]; other site 710686015318 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686015319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686015320 substrate binding pocket [chemical binding]; other site 710686015321 membrane-bound complex binding site; other site 710686015322 hinge residues; other site 710686015323 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 710686015324 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686015325 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710686015326 Ribosomal protein L34e; Region: Ribosomal_L34e; cl00955 710686015327 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015328 cyclase homology domain; Region: CHD; cd07302 710686015329 nucleotidyl binding site; other site 710686015330 metal binding site [ion binding]; metal-binding site 710686015331 dimer interface [polypeptide binding]; other site 710686015332 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710686015333 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 710686015334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686015335 catalytic residue [active] 710686015336 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 710686015337 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 710686015338 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710686015339 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 710686015340 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 710686015341 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 710686015342 dimerization interface [polypeptide binding]; other site 710686015343 putative ATP binding site [chemical binding]; other site 710686015344 Cupin domain; Region: Cupin_2; pfam07883 710686015345 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 710686015346 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710686015347 putative NAD(P) binding site [chemical binding]; other site 710686015348 putative active site [active] 710686015349 amidophosphoribosyltransferase; Provisional; Region: PRK07847 710686015350 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 710686015351 active site 710686015352 tetramer interface [polypeptide binding]; other site 710686015353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686015354 active site 710686015355 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015356 mce related protein; Region: MCE; pfam02470 710686015357 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686015358 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 710686015359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686015360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015361 NAD(P) binding site [chemical binding]; other site 710686015362 active site 710686015363 CAAX protease self-immunity; Region: Abi; pfam02517 710686015364 Predicted membrane protein [Function unknown]; Region: COG4425 710686015365 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710686015366 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 710686015367 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 710686015368 dimerization interface [polypeptide binding]; other site 710686015369 ATP binding site [chemical binding]; other site 710686015370 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 710686015371 dimerization interface [polypeptide binding]; other site 710686015372 ATP binding site [chemical binding]; other site 710686015373 thiamine pyrophosphate protein; Provisional; Region: PRK08273 710686015374 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 710686015375 PYR/PP interface [polypeptide binding]; other site 710686015376 dimer interface [polypeptide binding]; other site 710686015377 tetramer interface [polypeptide binding]; other site 710686015378 TPP binding site [chemical binding]; other site 710686015379 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710686015380 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 710686015381 TPP-binding site [chemical binding]; other site 710686015382 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686015383 active site 710686015384 metal binding site [ion binding]; metal-binding site 710686015385 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 710686015386 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 710686015387 active site 710686015388 metal binding site [ion binding]; metal-binding site 710686015389 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 710686015390 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 710686015391 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 710686015392 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 710686015393 putative active site [active] 710686015394 catalytic triad [active] 710686015395 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 710686015396 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710686015397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710686015398 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686015399 FAD binding domain; Region: FAD_binding_2; pfam00890 710686015400 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 710686015401 Predicted deacetylase [General function prediction only]; Region: COG3233 710686015402 putative active site [active] 710686015403 putative Zn binding site [ion binding]; other site 710686015404 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 710686015405 catalytic residues [active] 710686015406 dimer interface [polypeptide binding]; other site 710686015407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015409 WHG domain; Region: WHG; pfam13305 710686015410 Predicted membrane protein [Function unknown]; Region: COG4270 710686015411 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 710686015412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686015413 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 710686015414 ATP binding site [chemical binding]; other site 710686015415 active site 710686015416 substrate binding site [chemical binding]; other site 710686015417 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 710686015418 gating phenylalanine in ion channel; other site 710686015419 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 710686015420 homotrimer interaction site [polypeptide binding]; other site 710686015421 putative active site [active] 710686015422 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015423 Cytochrome P450; Region: p450; cl12078 710686015424 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 710686015425 Lyase; Region: Lyase_1; pfam00206 710686015426 tetramer interface [polypeptide binding]; other site 710686015427 active site 710686015428 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 710686015429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710686015430 short chain dehydrogenase; Provisional; Region: PRK06180 710686015431 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686015432 NADP binding site [chemical binding]; other site 710686015433 active site 710686015434 steroid binding site; other site 710686015435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015437 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 710686015438 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 710686015439 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 710686015440 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 710686015441 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710686015442 Amidinotransferase; Region: Amidinotransf; cl12043 710686015443 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015444 Cytochrome P450; Region: p450; cl12078 710686015445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015446 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710686015447 DNA-binding interface [nucleotide binding]; DNA binding site 710686015448 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686015449 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710686015450 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686015451 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710686015452 [2Fe-2S] cluster binding site [ion binding]; other site 710686015453 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710686015454 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686015455 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710686015456 short chain dehydrogenase; Provisional; Region: PRK07774 710686015457 classical (c) SDRs; Region: SDR_c; cd05233 710686015458 NAD(P) binding site [chemical binding]; other site 710686015459 active site 710686015460 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710686015461 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710686015462 NAD binding site [chemical binding]; other site 710686015463 catalytic residues [active] 710686015464 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015465 Cytochrome P450; Region: p450; cl12078 710686015466 short chain dehydrogenase; Provisional; Region: PRK07775 710686015467 classical (c) SDRs; Region: SDR_c; cd05233 710686015468 NAD(P) binding site [chemical binding]; other site 710686015469 active site 710686015470 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015471 Cytochrome P450; Region: p450; cl12078 710686015472 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686015473 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686015474 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710686015475 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686015476 NAD binding site [chemical binding]; other site 710686015477 catalytic Zn binding site [ion binding]; other site 710686015478 substrate binding site [chemical binding]; other site 710686015479 structural Zn binding site [ion binding]; other site 710686015480 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710686015481 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686015482 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686015483 classical (c) SDRs; Region: SDR_c; cd05233 710686015484 NAD(P) binding site [chemical binding]; other site 710686015485 active site 710686015486 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 710686015487 Ligand binding site; other site 710686015488 Ligand binding site; other site 710686015489 Ligand binding site; other site 710686015490 Putative Catalytic site; other site 710686015491 DXD motif; other site 710686015492 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 710686015493 nucleotide binding site/active site [active] 710686015494 HIT family signature motif; other site 710686015495 catalytic residue [active] 710686015496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710686015497 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710686015498 phosphopeptide binding site; other site 710686015499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686015501 DNA binding residues [nucleotide binding] 710686015502 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 710686015503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686015504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686015505 dimerization interface [polypeptide binding]; other site 710686015506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686015507 dimer interface [polypeptide binding]; other site 710686015508 phosphorylation site [posttranslational modification] 710686015509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686015510 ATP binding site [chemical binding]; other site 710686015511 Mg2+ binding site [ion binding]; other site 710686015512 G-X-G motif; other site 710686015513 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686015514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015515 active site 710686015516 phosphorylation site [posttranslational modification] 710686015517 intermolecular recognition site; other site 710686015518 dimerization interface [polypeptide binding]; other site 710686015519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686015520 DNA binding site [nucleotide binding] 710686015521 HNH endonuclease; Region: HNH_3; pfam13392 710686015522 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710686015523 Transglycosylase; Region: Transgly; pfam00912 710686015524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710686015525 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710686015526 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 710686015527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 710686015528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 710686015529 GAF domain; Region: GAF_2; pfam13185 710686015530 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710686015531 GAF domain; Region: GAF; pfam01590 710686015532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686015533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686015534 dimer interface [polypeptide binding]; other site 710686015535 phosphorylation site [posttranslational modification] 710686015536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686015537 ATP binding site [chemical binding]; other site 710686015538 Mg2+ binding site [ion binding]; other site 710686015539 G-X-G motif; other site 710686015540 Response regulator receiver domain; Region: Response_reg; pfam00072 710686015541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015542 active site 710686015543 phosphorylation site [posttranslational modification] 710686015544 intermolecular recognition site; other site 710686015545 dimerization interface [polypeptide binding]; other site 710686015546 Response regulator receiver domain; Region: Response_reg; pfam00072 710686015547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015548 active site 710686015549 phosphorylation site [posttranslational modification] 710686015550 intermolecular recognition site; other site 710686015551 dimerization interface [polypeptide binding]; other site 710686015552 Response regulator receiver domain; Region: Response_reg; pfam00072 710686015553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015554 active site 710686015555 phosphorylation site [posttranslational modification] 710686015556 intermolecular recognition site; other site 710686015557 dimerization interface [polypeptide binding]; other site 710686015558 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686015559 cyclase homology domain; Region: CHD; cd07302 710686015560 nucleotidyl binding site; other site 710686015561 metal binding site [ion binding]; metal-binding site 710686015562 dimer interface [polypeptide binding]; other site 710686015563 Cutinase; Region: Cutinase; pfam01083 710686015564 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710686015565 DKNYY family; Region: DKNYY; pfam13644 710686015566 DKNYY family; Region: DKNYY; pfam13644 710686015567 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 710686015568 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015569 Cytochrome P450; Region: p450; cl12078 710686015570 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 710686015571 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 710686015572 XdhC Rossmann domain; Region: XdhC_C; pfam13478 710686015573 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710686015574 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710686015575 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710686015576 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 710686015577 putative hydrophobic ligand binding site [chemical binding]; other site 710686015578 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710686015579 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710686015580 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710686015581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686015582 catalytic loop [active] 710686015583 iron binding site [ion binding]; other site 710686015584 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710686015585 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710686015586 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710686015587 short chain dehydrogenase; Provisional; Region: PRK05875 710686015588 classical (c) SDRs; Region: SDR_c; cd05233 710686015589 NAD(P) binding site [chemical binding]; other site 710686015590 active site 710686015591 enoyl-CoA hydratase; Provisional; Region: PRK08290 710686015592 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686015593 substrate binding site [chemical binding]; other site 710686015594 oxyanion hole (OAH) forming residues; other site 710686015595 trimer interface [polypeptide binding]; other site 710686015596 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 710686015597 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 710686015598 active site 710686015599 homotetramer interface [polypeptide binding]; other site 710686015600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015601 mce related protein; Region: MCE; pfam02470 710686015602 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015603 mce related protein; Region: MCE; pfam02470 710686015604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015605 mce related protein; Region: MCE; pfam02470 710686015606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015607 mce related protein; Region: MCE; pfam02470 710686015608 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015609 mce related protein; Region: MCE; pfam02470 710686015610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710686015611 mce related protein; Region: MCE; pfam02470 710686015612 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710686015613 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686015614 Permease; Region: Permease; pfam02405 710686015615 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710686015616 Permease; Region: Permease; pfam02405 710686015617 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 710686015618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015619 NAD(P) binding site [chemical binding]; other site 710686015620 active site 710686015621 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710686015622 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710686015623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015624 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710686015625 FAD binding site [chemical binding]; other site 710686015626 substrate binding site [chemical binding]; other site 710686015627 catalytic base [active] 710686015628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015629 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686015630 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710686015631 active site 710686015632 acyl-CoA synthetase; Validated; Region: PRK07867 710686015633 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 710686015634 acyl-activating enzyme (AAE) consensus motif; other site 710686015635 putative AMP binding site [chemical binding]; other site 710686015636 putative active site [active] 710686015637 putative CoA binding site [chemical binding]; other site 710686015638 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 710686015639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710686015640 active site 710686015641 metal binding site [ion binding]; metal-binding site 710686015642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686015643 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710686015644 Nitronate monooxygenase; Region: NMO; pfam03060 710686015645 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686015646 FMN binding site [chemical binding]; other site 710686015647 substrate binding site [chemical binding]; other site 710686015648 putative catalytic residue [active] 710686015649 acyl-CoA synthetase; Validated; Region: PRK07798 710686015650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686015651 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710686015652 acyl-activating enzyme (AAE) consensus motif; other site 710686015653 acyl-activating enzyme (AAE) consensus motif; other site 710686015654 putative AMP binding site [chemical binding]; other site 710686015655 putative active site [active] 710686015656 putative CoA binding site [chemical binding]; other site 710686015657 enoyl-CoA hydratase; Provisional; Region: PRK07799 710686015658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686015659 substrate binding site [chemical binding]; other site 710686015660 oxyanion hole (OAH) forming residues; other site 710686015661 trimer interface [polypeptide binding]; other site 710686015662 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 710686015663 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686015664 acyl-activating enzyme (AAE) consensus motif; other site 710686015665 active site 710686015666 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015667 Cytochrome P450; Region: p450; cl12078 710686015668 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 710686015669 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686015670 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710686015671 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686015672 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686015673 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686015674 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686015675 lipid-transfer protein; Provisional; Region: PRK07937 710686015676 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686015677 active site 710686015678 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 710686015679 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686015680 active site 710686015681 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686015682 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686015683 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710686015684 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 710686015685 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 710686015686 MOSC domain; Region: MOSC; pfam03473 710686015687 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710686015688 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710686015689 trimer interface [polypeptide binding]; other site 710686015690 putative metal binding site [ion binding]; other site 710686015691 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710686015692 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710686015693 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 710686015694 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 710686015695 short chain dehydrogenase; Provisional; Region: PRK07890 710686015696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015697 NAD(P) binding site [chemical binding]; other site 710686015698 active site 710686015699 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710686015700 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 710686015701 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 710686015702 Predicted permease; Region: DUF318; cl17795 710686015703 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710686015704 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710686015705 active site 710686015706 catalytic residues [active] 710686015707 metal binding site [ion binding]; metal-binding site 710686015708 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710686015709 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710686015710 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710686015711 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710686015712 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 710686015713 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 710686015714 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710686015715 enoyl-CoA hydratase; Region: PLN02864 710686015716 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686015717 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710686015718 dimer interaction site [polypeptide binding]; other site 710686015719 substrate-binding tunnel; other site 710686015720 active site 710686015721 catalytic site [active] 710686015722 substrate binding site [chemical binding]; other site 710686015723 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710686015724 putative catalytic site [active] 710686015725 putative metal binding site [ion binding]; other site 710686015726 putative phosphate binding site [ion binding]; other site 710686015727 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 710686015728 active site 710686015729 catalytic residues [active] 710686015730 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 710686015731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710686015732 FeS/SAM binding site; other site 710686015733 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710686015734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686015735 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710686015736 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710686015737 acyl-activating enzyme (AAE) consensus motif; other site 710686015738 AMP binding site [chemical binding]; other site 710686015739 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 710686015740 putative active site [active] 710686015741 putative metal binding site [ion binding]; other site 710686015742 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 710686015743 active site 710686015744 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686015745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015746 NAD(P) binding site [chemical binding]; other site 710686015747 active site 710686015748 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686015749 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710686015750 Ligand binding site; other site 710686015751 Putative Catalytic site; other site 710686015752 DXD motif; other site 710686015753 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710686015754 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710686015755 active site 710686015756 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710686015757 dimer interface [polypeptide binding]; other site 710686015758 active site 710686015759 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710686015760 dimer interface [polypeptide binding]; other site 710686015761 active site 710686015762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015764 active site 710686015765 intermolecular recognition site; other site 710686015766 dimerization interface [polypeptide binding]; other site 710686015767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686015768 DNA binding residues [nucleotide binding] 710686015769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686015770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686015771 active site 710686015772 intermolecular recognition site; other site 710686015773 dimerization interface [polypeptide binding]; other site 710686015774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686015775 DNA binding residues [nucleotide binding] 710686015776 dimerization interface [polypeptide binding]; other site 710686015777 lipid-transfer protein; Provisional; Region: PRK07855 710686015778 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710686015779 active site 710686015780 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 710686015781 putative active site [active] 710686015782 putative catalytic site [active] 710686015783 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686015784 active site 710686015785 catalytic site [active] 710686015786 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710686015787 DUF35 OB-fold domain; Region: DUF35; pfam01796 710686015788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015790 active site 710686015791 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 710686015792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015793 active site 710686015794 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015795 Cytochrome P450; Region: p450; cl12078 710686015796 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 710686015797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686015798 dimer interface [polypeptide binding]; other site 710686015799 active site 710686015800 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686015801 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710686015802 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710686015803 short chain dehydrogenase; Provisional; Region: PRK07791 710686015804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015805 NAD(P) binding site [chemical binding]; other site 710686015806 active site 710686015807 short chain dehydrogenase; Provisional; Region: PRK07856 710686015808 classical (c) SDRs; Region: SDR_c; cd05233 710686015809 NAD(P) binding site [chemical binding]; other site 710686015810 active site 710686015811 enoyl-CoA hydratase; Provisional; Region: PRK06495 710686015812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686015813 substrate binding site [chemical binding]; other site 710686015814 oxyanion hole (OAH) forming residues; other site 710686015815 trimer interface [polypeptide binding]; other site 710686015816 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710686015817 Coenzyme A transferase; Region: CoA_trans; cl17247 710686015818 Nitronate monooxygenase; Region: NMO; pfam03060 710686015819 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710686015820 FMN binding site [chemical binding]; other site 710686015821 substrate binding site [chemical binding]; other site 710686015822 putative catalytic residue [active] 710686015823 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710686015824 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710686015825 NAD binding site [chemical binding]; other site 710686015826 catalytic Zn binding site [ion binding]; other site 710686015827 substrate binding site [chemical binding]; other site 710686015828 structural Zn binding site [ion binding]; other site 710686015829 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710686015830 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710686015831 dimer interface [polypeptide binding]; other site 710686015832 active site 710686015833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015835 short chain dehydrogenase; Provisional; Region: PRK07831 710686015836 classical (c) SDRs; Region: SDR_c; cd05233 710686015837 NAD(P) binding site [chemical binding]; other site 710686015838 active site 710686015839 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015841 active site 710686015842 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710686015843 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686015844 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710686015845 acyl-activating enzyme (AAE) consensus motif; other site 710686015846 putative AMP binding site [chemical binding]; other site 710686015847 putative active site [active] 710686015848 putative CoA binding site [chemical binding]; other site 710686015849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015851 active site 710686015852 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686015853 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015855 active site 710686015856 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710686015857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015858 active site 710686015859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686015860 S-adenosylmethionine binding site [chemical binding]; other site 710686015861 aspartate aminotransferase; Provisional; Region: PRK05764 710686015862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686015863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686015864 homodimer interface [polypeptide binding]; other site 710686015865 catalytic residue [active] 710686015866 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 710686015867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686015868 acyl-activating enzyme (AAE) consensus motif; other site 710686015869 AMP binding site [chemical binding]; other site 710686015870 active site 710686015871 CoA binding site [chemical binding]; other site 710686015872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686015873 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 710686015874 NAD(P) binding site [chemical binding]; other site 710686015875 active site 710686015876 metabolite-proton symporter; Region: 2A0106; TIGR00883 710686015877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710686015878 putative substrate translocation pore; other site 710686015879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710686015880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710686015881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710686015882 dimerization interface [polypeptide binding]; other site 710686015883 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710686015884 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686015885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686015886 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710686015887 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710686015888 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710686015889 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710686015890 active site 710686015891 Fe binding site [ion binding]; other site 710686015892 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710686015893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686015894 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015895 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 710686015896 Flavin binding site [chemical binding]; other site 710686015897 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710686015898 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710686015899 FAD binding pocket [chemical binding]; other site 710686015900 FAD binding motif [chemical binding]; other site 710686015901 phosphate binding motif [ion binding]; other site 710686015902 beta-alpha-beta structure motif; other site 710686015903 NAD(p) ribose binding residues [chemical binding]; other site 710686015904 NAD binding pocket [chemical binding]; other site 710686015905 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710686015906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710686015907 catalytic loop [active] 710686015908 iron binding site [ion binding]; other site 710686015909 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710686015910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015911 active site 710686015912 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686015913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686015914 active site 710686015915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686015916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686015917 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 710686015918 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 710686015919 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710686015920 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710686015921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710686015922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710686015923 DNA binding site [nucleotide binding] 710686015924 domain linker motif; other site 710686015925 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 710686015926 putative dimerization interface [polypeptide binding]; other site 710686015927 putative ligand binding site [chemical binding]; other site 710686015928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710686015929 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 710686015930 intersubunit interface [polypeptide binding]; other site 710686015931 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710686015932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686015933 Walker A/P-loop; other site 710686015934 ATP binding site [chemical binding]; other site 710686015935 Q-loop/lid; other site 710686015936 ABC transporter signature motif; other site 710686015937 Walker B; other site 710686015938 D-loop; other site 710686015939 H-loop/switch region; other site 710686015940 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710686015941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 710686015942 putative PBP binding regions; other site 710686015943 ABC-ATPase subunit interface; other site 710686015944 AMP-binding domain protein; Validated; Region: PRK08315 710686015945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686015946 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710686015947 acyl-activating enzyme (AAE) consensus motif; other site 710686015948 acyl-activating enzyme (AAE) consensus motif; other site 710686015949 putative AMP binding site [chemical binding]; other site 710686015950 putative active site [active] 710686015951 putative CoA binding site [chemical binding]; other site 710686015952 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710686015953 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710686015954 active site residue [active] 710686015955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710686015956 active site residue [active] 710686015957 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 710686015958 putative FMN binding site [chemical binding]; other site 710686015959 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 710686015960 putative active site [active] 710686015961 30S ribosomal protein S18; Provisional; Region: PRK13401 710686015962 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 710686015963 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710686015964 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686015965 Cytochrome P450; Region: p450; cl12078 710686015966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686015967 S-adenosylmethionine binding site [chemical binding]; other site 710686015968 short chain dehydrogenase; Validated; Region: PRK06182 710686015969 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710686015970 NADP binding site [chemical binding]; other site 710686015971 active site 710686015972 steroid binding site; other site 710686015973 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710686015974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686015975 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686015976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686015977 Nitroreductase family; Region: Nitroreductase; pfam00881 710686015978 FMN binding site [chemical binding]; other site 710686015979 dimer interface [polypeptide binding]; other site 710686015980 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710686015981 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710686015982 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686015983 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686015984 acyltransferase PapA5; Provisional; Region: PRK09294 710686015985 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686015986 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686015987 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686015988 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686015989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686015990 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710686015991 Walker A/P-loop; other site 710686015992 ATP binding site [chemical binding]; other site 710686015993 Q-loop/lid; other site 710686015994 ABC transporter signature motif; other site 710686015995 Walker B; other site 710686015996 D-loop; other site 710686015997 H-loop/switch region; other site 710686015998 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710686015999 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686016000 active site 710686016001 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686016002 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686016003 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686016004 Condensation domain; Region: Condensation; pfam00668 710686016005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710686016006 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710686016007 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710686016008 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686016009 active site 710686016010 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686016011 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710686016012 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710686016013 KR domain; Region: KR; pfam08659 710686016014 putative NADP binding site [chemical binding]; other site 710686016015 active site 710686016016 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016017 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710686016018 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686016019 active site 710686016020 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686016021 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710686016022 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710686016023 putative NADP binding site [chemical binding]; other site 710686016024 KR domain; Region: KR; pfam08659 710686016025 active site 710686016026 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686016029 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710686016030 active site 710686016031 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686016032 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686016033 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 710686016034 KR domain; Region: KR; pfam08659 710686016035 NADP binding site [chemical binding]; other site 710686016036 active site 710686016037 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016038 acyl-CoA synthetase; Validated; Region: PRK05850 710686016039 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686016040 acyl-activating enzyme (AAE) consensus motif; other site 710686016041 active site 710686016042 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 710686016043 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710686016044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710686016045 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710686016046 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 710686016047 transmembrane helices; other site 710686016048 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710686016049 active site 710686016050 catalytic triad [active] 710686016051 oxyanion hole [active] 710686016052 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710686016053 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710686016054 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710686016055 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710686016056 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686016057 active site 710686016058 HIGH motif; other site 710686016059 nucleotide binding site [chemical binding]; other site 710686016060 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710686016061 KMSKS motif; other site 710686016062 tRNA binding surface [nucleotide binding]; other site 710686016063 anticodon binding site; other site 710686016064 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 710686016065 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 710686016066 homotrimer interaction site [polypeptide binding]; other site 710686016067 zinc binding site [ion binding]; other site 710686016068 CDP-binding sites; other site 710686016069 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 710686016070 Protein of unknown function (DUF461); Region: DUF461; cl01071 710686016071 DNA repair protein RadA; Provisional; Region: PRK11823 710686016072 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 710686016073 Walker A motif/ATP binding site; other site 710686016074 ATP binding site [chemical binding]; other site 710686016075 Walker B motif; other site 710686016076 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710686016077 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 710686016078 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710686016079 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 710686016080 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710686016081 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 710686016082 active site clefts [active] 710686016083 zinc binding site [ion binding]; other site 710686016084 dimer interface [polypeptide binding]; other site 710686016085 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710686016086 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710686016087 minor groove reading motif; other site 710686016088 helix-hairpin-helix signature motif; other site 710686016089 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 710686016090 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686016091 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710686016092 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686016093 cyclase homology domain; Region: CHD; cd07302 710686016094 nucleotidyl binding site; other site 710686016095 metal binding site [ion binding]; metal-binding site 710686016096 dimer interface [polypeptide binding]; other site 710686016097 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710686016098 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710686016099 conserved cys residue [active] 710686016100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686016101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686016102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686016103 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 710686016104 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 710686016105 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710686016106 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686016107 catalytic core [active] 710686016108 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 710686016109 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 710686016110 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 710686016111 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 710686016112 Clp amino terminal domain; Region: Clp_N; pfam02861 710686016113 Clp amino terminal domain; Region: Clp_N; pfam02861 710686016114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686016115 Walker A motif; other site 710686016116 ATP binding site [chemical binding]; other site 710686016117 Walker B motif; other site 710686016118 arginine finger; other site 710686016119 UvrB/uvrC motif; Region: UVR; pfam02151 710686016120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686016121 Walker A motif; other site 710686016122 ATP binding site [chemical binding]; other site 710686016123 Walker B motif; other site 710686016124 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710686016125 Lsr2; Region: Lsr2; pfam11774 710686016126 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 710686016127 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710686016128 dimer interface [polypeptide binding]; other site 710686016129 putative anticodon binding site; other site 710686016130 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710686016131 motif 1; other site 710686016132 dimer interface [polypeptide binding]; other site 710686016133 active site 710686016134 motif 2; other site 710686016135 motif 3; other site 710686016136 pantothenate kinase; Reviewed; Region: PRK13318 710686016137 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 710686016138 tetramerization interface [polypeptide binding]; other site 710686016139 active site 710686016140 Pantoate-beta-alanine ligase; Region: PanC; cd00560 710686016141 pantoate--beta-alanine ligase; Region: panC; TIGR00018 710686016142 active site 710686016143 ATP-binding site [chemical binding]; other site 710686016144 pantoate-binding site; other site 710686016145 HXXH motif; other site 710686016146 Rossmann-like domain; Region: Rossmann-like; pfam10727 710686016147 Uncharacterized conserved protein [Function unknown]; Region: COG5495 710686016148 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 710686016149 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 710686016150 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 710686016151 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 710686016152 catalytic center binding site [active] 710686016153 ATP binding site [chemical binding]; other site 710686016154 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 710686016155 homooctamer interface [polypeptide binding]; other site 710686016156 active site 710686016157 dihydropteroate synthase; Region: DHPS; TIGR01496 710686016158 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710686016159 substrate binding pocket [chemical binding]; other site 710686016160 dimer interface [polypeptide binding]; other site 710686016161 inhibitor binding site; inhibition site 710686016162 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 710686016163 homodecamer interface [polypeptide binding]; other site 710686016164 GTP cyclohydrolase I; Provisional; Region: PLN03044 710686016165 active site 710686016166 putative catalytic site residues [active] 710686016167 zinc binding site [ion binding]; other site 710686016168 GTP-CH-I/GFRP interaction surface; other site 710686016169 FtsH Extracellular; Region: FtsH_ext; pfam06480 710686016170 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710686016171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686016172 Walker A motif; other site 710686016173 ATP binding site [chemical binding]; other site 710686016174 Walker B motif; other site 710686016175 arginine finger; other site 710686016176 Peptidase family M41; Region: Peptidase_M41; pfam01434 710686016177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686016178 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710686016179 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686016180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686016181 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710686016182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686016183 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686016184 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 710686016185 putative NAD(P) binding site [chemical binding]; other site 710686016186 catalytic Zn binding site [ion binding]; other site 710686016187 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 710686016188 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710686016189 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710686016190 molybdopterin cofactor binding site; other site 710686016191 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710686016192 putative molybdopterin cofactor binding site; other site 710686016193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686016194 active site 710686016195 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710686016196 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710686016197 Ligand Binding Site [chemical binding]; other site 710686016198 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710686016199 putative hydrolase; Region: TIGR03624 710686016200 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 710686016201 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 710686016202 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710686016203 dimer interface [polypeptide binding]; other site 710686016204 substrate binding site [chemical binding]; other site 710686016205 metal binding sites [ion binding]; metal-binding site 710686016206 putative OHCU decarboxylase; Provisional; Region: PRK13798 710686016207 RyR domain; Region: RyR; pfam02026 710686016208 TIR domain; Region: TIR_2; pfam13676 710686016209 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686016210 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686016211 structural tetrad; other site 710686016212 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 710686016213 structural tetrad; other site 710686016214 FOG: WD40 repeat [General function prediction only]; Region: COG2319 710686016215 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686016216 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686016217 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 710686016218 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710686016219 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710686016220 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710686016221 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686016222 acyl-activating enzyme (AAE) consensus motif; other site 710686016223 AMP binding site [chemical binding]; other site 710686016224 active site 710686016225 CoA binding site [chemical binding]; other site 710686016226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710686016227 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 710686016228 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710686016229 putative trimer interface [polypeptide binding]; other site 710686016230 putative CoA binding site [chemical binding]; other site 710686016231 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710686016232 putative trimer interface [polypeptide binding]; other site 710686016233 putative CoA binding site [chemical binding]; other site 710686016234 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 710686016235 Peptidase family M1; Region: Peptidase_M1; pfam01433 710686016236 Zn binding site [ion binding]; other site 710686016237 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710686016238 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710686016239 Ligand binding site; other site 710686016240 Putative Catalytic site; other site 710686016241 DXD motif; other site 710686016242 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 710686016243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686016244 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710686016245 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686016246 active site 710686016247 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710686016248 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686016249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686016250 NAD(P) binding site [chemical binding]; other site 710686016251 active site 710686016252 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710686016253 DNA polymerase III subunit delta'; Validated; Region: PRK07940 710686016254 DNA polymerase III subunit delta'; Validated; Region: PRK08485 710686016255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686016256 dimerization interface [polypeptide binding]; other site 710686016257 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686016258 cyclase homology domain; Region: CHD; cd07302 710686016259 nucleotidyl binding site; other site 710686016260 metal binding site [ion binding]; metal-binding site 710686016261 dimer interface [polypeptide binding]; other site 710686016262 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 710686016263 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 710686016264 active site 710686016265 interdomain interaction site; other site 710686016266 putative metal-binding site [ion binding]; other site 710686016267 nucleotide binding site [chemical binding]; other site 710686016268 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 710686016269 domain I; other site 710686016270 phosphate binding site [ion binding]; other site 710686016271 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 710686016272 domain II; other site 710686016273 domain III; other site 710686016274 nucleotide binding site [chemical binding]; other site 710686016275 DNA binding groove [nucleotide binding] 710686016276 catalytic site [active] 710686016277 domain IV; other site 710686016278 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710686016279 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710686016280 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710686016281 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710686016282 DNA-binding site [nucleotide binding]; DNA binding site 710686016283 RNA-binding motif; other site 710686016284 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 710686016285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686016286 ATP binding site [chemical binding]; other site 710686016287 putative Mg++ binding site [ion binding]; other site 710686016288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686016289 nucleotide binding region [chemical binding]; other site 710686016290 ATP-binding site [chemical binding]; other site 710686016291 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 710686016292 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 710686016293 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710686016294 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710686016295 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 710686016296 ATP binding site [chemical binding]; other site 710686016297 Walker A motif; other site 710686016298 hexamer interface [polypeptide binding]; other site 710686016299 Walker B motif; other site 710686016300 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 710686016301 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710686016302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686016303 motif II; other site 710686016304 acetyl-CoA synthetase; Provisional; Region: PRK00174 710686016305 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 710686016306 active site 710686016307 CoA binding site [chemical binding]; other site 710686016308 acyl-activating enzyme (AAE) consensus motif; other site 710686016309 AMP binding site [chemical binding]; other site 710686016310 acetate binding site [chemical binding]; other site 710686016311 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710686016312 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686016313 Colicin V production protein; Region: Colicin_V; pfam02674 710686016314 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710686016315 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686016316 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710686016317 putative active site [active] 710686016318 putative CoA binding site [chemical binding]; other site 710686016319 nudix motif; other site 710686016320 metal binding site [ion binding]; metal-binding site 710686016321 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710686016322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686016323 catalytic residues [active] 710686016324 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710686016325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710686016326 minor groove reading motif; other site 710686016327 helix-hairpin-helix signature motif; other site 710686016328 substrate binding pocket [chemical binding]; other site 710686016329 active site 710686016330 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710686016331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686016332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686016333 ligand binding site [chemical binding]; other site 710686016334 flexible hinge region; other site 710686016335 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710686016336 putative switch regulator; other site 710686016337 non-specific DNA interactions [nucleotide binding]; other site 710686016338 DNA binding site [nucleotide binding] 710686016339 sequence specific DNA binding site [nucleotide binding]; other site 710686016340 putative cAMP binding site [chemical binding]; other site 710686016341 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686016342 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 710686016343 homotrimer interaction site [polypeptide binding]; other site 710686016344 putative active site [active] 710686016345 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 710686016346 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710686016347 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710686016348 P loop; other site 710686016349 Nucleotide binding site [chemical binding]; other site 710686016350 DTAP/Switch II; other site 710686016351 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710686016352 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710686016353 DTAP/Switch II; other site 710686016354 Switch I; other site 710686016355 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710686016356 Transcription factor WhiB; Region: Whib; pfam02467 710686016357 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710686016358 Transglycosylase; Region: Transgly; pfam00912 710686016359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710686016360 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710686016361 phosphodiesterase YaeI; Provisional; Region: PRK11340 710686016362 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710686016363 putative active site [active] 710686016364 putative metal binding site [ion binding]; other site 710686016365 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710686016366 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710686016367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686016368 catalytic residue [active] 710686016369 Uncharacterized conserved protein [Function unknown]; Region: COG5361 710686016370 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 710686016371 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710686016372 Uncharacterized conserved protein [Function unknown]; Region: COG5361 710686016373 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 710686016374 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 710686016375 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 710686016376 putative methyltransferase; Provisional; Region: PRK14967 710686016377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686016378 S-adenosylmethionine binding site [chemical binding]; other site 710686016379 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686016380 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 710686016381 Yqey-like protein; Region: YqeY; pfam09424 710686016382 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710686016383 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 710686016384 MoxR-like ATPases [General function prediction only]; Region: COG0714 710686016385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686016386 Walker A motif; other site 710686016387 ATP binding site [chemical binding]; other site 710686016388 Walker B motif; other site 710686016389 arginine finger; other site 710686016390 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710686016391 Protein of unknown function DUF58; Region: DUF58; pfam01882 710686016392 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 710686016393 Predicted membrane protein/domain [Function unknown]; Region: COG1714 710686016394 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 710686016395 Protein of unknown function (DUF998); Region: DUF998; pfam06197 710686016396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686016397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686016398 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 710686016399 Cupin; Region: Cupin_6; pfam12852 710686016400 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710686016401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710686016402 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 710686016403 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710686016404 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710686016405 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710686016406 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686016407 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710686016408 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710686016409 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710686016410 active site 710686016411 catalytic tetrad [active] 710686016412 glycerol kinase; Provisional; Region: glpK; PRK00047 710686016413 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 710686016414 N- and C-terminal domain interface [polypeptide binding]; other site 710686016415 active site 710686016416 MgATP binding site [chemical binding]; other site 710686016417 catalytic site [active] 710686016418 metal binding site [ion binding]; metal-binding site 710686016419 putative homotetramer interface [polypeptide binding]; other site 710686016420 glycerol binding site [chemical binding]; other site 710686016421 homodimer interface [polypeptide binding]; other site 710686016422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686016423 S-adenosylmethionine binding site [chemical binding]; other site 710686016424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686016425 S-adenosylmethionine binding site [chemical binding]; other site 710686016426 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 710686016427 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710686016428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686016429 catalytic residue [active] 710686016430 Uncharacterized conserved protein [Function unknown]; Region: COG4301 710686016431 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 710686016432 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 710686016433 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710686016434 putative active site [active] 710686016435 putative dimer interface [polypeptide binding]; other site 710686016436 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 710686016437 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710686016438 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 710686016439 PknH-like extracellular domain; Region: PknH_C; pfam14032 710686016440 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 710686016441 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710686016442 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 710686016443 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710686016444 aspartate kinase; Reviewed; Region: PRK06635 710686016445 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 710686016446 putative nucleotide binding site [chemical binding]; other site 710686016447 putative catalytic residues [active] 710686016448 putative Mg ion binding site [ion binding]; other site 710686016449 putative aspartate binding site [chemical binding]; other site 710686016450 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 710686016451 putative allosteric regulatory site; other site 710686016452 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 710686016453 putative allosteric regulatory residue; other site 710686016454 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710686016455 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 710686016456 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710686016457 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710686016458 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 710686016459 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710686016460 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710686016461 active site 710686016462 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 710686016463 domain_subunit interface; other site 710686016464 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710686016465 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 710686016466 active site 710686016467 FMN binding site [chemical binding]; other site 710686016468 substrate binding site [chemical binding]; other site 710686016469 3Fe-4S cluster binding site [ion binding]; other site 710686016470 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686016471 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 710686016472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686016473 non-specific DNA binding site [nucleotide binding]; other site 710686016474 salt bridge; other site 710686016475 sequence-specific DNA binding site [nucleotide binding]; other site 710686016476 Cupin domain; Region: Cupin_2; pfam07883 710686016477 2-isopropylmalate synthase; Validated; Region: PRK03739 710686016478 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 710686016479 active site 710686016480 catalytic residues [active] 710686016481 metal binding site [ion binding]; metal-binding site 710686016482 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710686016483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710686016484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686016485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686016486 active site 710686016487 metal binding site [ion binding]; metal-binding site 710686016488 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686016489 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686016490 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686016491 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710686016492 active site 710686016493 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710686016494 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710686016495 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710686016496 active site 710686016497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686016498 Cytochrome P450; Region: p450; cl12078 710686016499 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 710686016500 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710686016501 active site 710686016502 catalytic site [active] 710686016503 substrate binding site [chemical binding]; other site 710686016504 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 710686016505 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710686016506 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 710686016507 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710686016508 catalytic triad [active] 710686016509 recombination protein RecR; Reviewed; Region: recR; PRK00076 710686016510 RecR protein; Region: RecR; pfam02132 710686016511 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710686016512 putative active site [active] 710686016513 putative metal-binding site [ion binding]; other site 710686016514 tetramer interface [polypeptide binding]; other site 710686016515 hypothetical protein; Validated; Region: PRK00153 710686016516 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710686016517 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710686016518 active site 710686016519 metal binding site [ion binding]; metal-binding site 710686016520 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 710686016521 hydrophobic ligand binding site; other site 710686016522 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686016523 FAD binding domain; Region: FAD_binding_4; pfam01565 710686016524 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710686016525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686016526 S-adenosylmethionine binding site [chemical binding]; other site 710686016527 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 710686016528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686016529 Walker A motif; other site 710686016530 ATP binding site [chemical binding]; other site 710686016531 Walker B motif; other site 710686016532 arginine finger; other site 710686016533 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 710686016534 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 710686016535 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686016536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686016537 catalytic residue [active] 710686016538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686016539 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710686016540 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710686016541 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686016542 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686016543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686016544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686016545 active site 710686016546 ATP binding site [chemical binding]; other site 710686016547 substrate binding site [chemical binding]; other site 710686016548 activation loop (A-loop); other site 710686016549 Cutinase; Region: Cutinase; pfam01083 710686016550 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 710686016551 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 710686016552 tetramer interface [polypeptide binding]; other site 710686016553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686016554 catalytic residue [active] 710686016555 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710686016556 nucleotide binding site [chemical binding]; other site 710686016557 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710686016558 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710686016559 active site 710686016560 DNA binding site [nucleotide binding] 710686016561 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710686016562 DNA binding site [nucleotide binding] 710686016563 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710686016564 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710686016565 active site 710686016566 DNA binding site [nucleotide binding] 710686016567 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710686016568 DNA binding site [nucleotide binding] 710686016569 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710686016570 Phosphotransferase enzyme family; Region: APH; pfam01636 710686016571 active site 710686016572 ATP binding site [chemical binding]; other site 710686016573 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 710686016574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710686016575 inhibitor-cofactor binding pocket; inhibition site 710686016576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686016577 catalytic residue [active] 710686016578 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 710686016579 active site 710686016580 HIGH motif; other site 710686016581 nucleotide binding site [chemical binding]; other site 710686016582 active site 710686016583 KMSKS motif; other site 710686016584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686016585 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686016586 substrate binding pocket [chemical binding]; other site 710686016587 membrane-bound complex binding site; other site 710686016588 hinge residues; other site 710686016589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710686016590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686016591 dimer interface [polypeptide binding]; other site 710686016592 conserved gate region; other site 710686016593 putative PBP binding loops; other site 710686016594 ABC-ATPase subunit interface; other site 710686016595 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710686016596 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710686016597 Walker A/P-loop; other site 710686016598 ATP binding site [chemical binding]; other site 710686016599 Q-loop/lid; other site 710686016600 ABC transporter signature motif; other site 710686016601 Walker B; other site 710686016602 D-loop; other site 710686016603 H-loop/switch region; other site 710686016604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710686016605 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 710686016606 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686016607 Cytochrome P450; Region: p450; cl12078 710686016608 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 710686016609 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 710686016610 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710686016611 haloalkane dehalogenase; Provisional; Region: PRK00870 710686016612 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710686016613 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686016614 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016615 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016616 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710686016617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686016618 Protein kinase domain; Region: Pkinase; pfam00069 710686016619 active site 710686016620 ATP binding site [chemical binding]; other site 710686016621 substrate binding site [chemical binding]; other site 710686016622 activation loop (A-loop); other site 710686016623 AAA domain; Region: AAA_11; pfam13086 710686016624 Part of AAA domain; Region: AAA_19; pfam13245 710686016625 AAA domain; Region: AAA_12; pfam13087 710686016626 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710686016627 putative active site [active] 710686016628 catalytic site [active] 710686016629 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 710686016630 HsdM N-terminal domain; Region: HsdM_N; pfam12161 710686016631 Methyltransferase domain; Region: Methyltransf_26; pfam13659 710686016632 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 710686016633 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710686016634 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 710686016635 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710686016636 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 710686016637 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 710686016638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686016639 ATP binding site [chemical binding]; other site 710686016640 putative Mg++ binding site [ion binding]; other site 710686016641 Protein of unknown function DUF45; Region: DUF45; pfam01863 710686016642 multiple promoter invertase; Provisional; Region: mpi; PRK13413 710686016643 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 710686016644 catalytic residues [active] 710686016645 catalytic nucleophile [active] 710686016646 Presynaptic Site I dimer interface [polypeptide binding]; other site 710686016647 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 710686016648 Synaptic Flat tetramer interface [polypeptide binding]; other site 710686016649 Synaptic Site I dimer interface [polypeptide binding]; other site 710686016650 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710686016651 DNA-binding interface [nucleotide binding]; DNA binding site 710686016652 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710686016653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710686016654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710686016655 non-specific DNA binding site [nucleotide binding]; other site 710686016656 salt bridge; other site 710686016657 sequence-specific DNA binding site [nucleotide binding]; other site 710686016658 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710686016659 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016660 Helix-turn-helix domain; Region: HTH_17; cl17695 710686016661 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016662 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016663 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 710686016664 nucleotide binding site [chemical binding]; other site 710686016665 AAA domain; Region: AAA_25; pfam13481 710686016666 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710686016667 Walker A motif; other site 710686016668 ATP binding site [chemical binding]; other site 710686016669 Walker B motif; other site 710686016670 Helix-turn-helix domain; Region: HTH_17; pfam12728 710686016671 Helix-turn-helix domain; Region: HTH_17; cl17695 710686016672 integrase; Provisional; Region: int; PHA02601 710686016673 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710686016674 active site 710686016675 Int/Topo IB signature motif; other site 710686016676 DNA binding site [nucleotide binding] 710686016677 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710686016678 nucleoside/Zn binding site; other site 710686016679 dimer interface [polypeptide binding]; other site 710686016680 catalytic motif [active] 710686016681 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 710686016682 prephenate dehydrogenase; Validated; Region: PRK06545 710686016683 prephenate dehydrogenase; Validated; Region: PRK08507 710686016684 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 710686016685 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710686016686 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710686016687 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 710686016688 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710686016689 Walker A/P-loop; other site 710686016690 ATP binding site [chemical binding]; other site 710686016691 Q-loop/lid; other site 710686016692 ABC transporter signature motif; other site 710686016693 Walker B; other site 710686016694 D-loop; other site 710686016695 H-loop/switch region; other site 710686016696 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710686016697 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 710686016698 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710686016699 putative active site [active] 710686016700 putative substrate binding site [chemical binding]; other site 710686016701 ATP binding site [chemical binding]; other site 710686016702 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686016703 catalytic core [active] 710686016704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710686016705 classical (c) SDRs; Region: SDR_c; cd05233 710686016706 NAD(P) binding site [chemical binding]; other site 710686016707 active site 710686016708 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 710686016709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686016710 Protein of unknown function (DUF419); Region: DUF419; cl15265 710686016711 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 710686016712 active site 710686016713 metal binding site [ion binding]; metal-binding site 710686016714 homotetramer interface [polypeptide binding]; other site 710686016715 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710686016716 iron-sulfur cluster [ion binding]; other site 710686016717 [2Fe-2S] cluster binding site [ion binding]; other site 710686016718 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710686016719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686016720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686016721 DNA binding residues [nucleotide binding] 710686016722 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686016723 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686016724 cyclase homology domain; Region: CHD; cd07302 710686016725 nucleotidyl binding site; other site 710686016726 metal binding site [ion binding]; metal-binding site 710686016727 dimer interface [polypeptide binding]; other site 710686016728 AAA ATPase domain; Region: AAA_16; pfam13191 710686016729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686016730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686016731 DNA binding residues [nucleotide binding] 710686016732 dimerization interface [polypeptide binding]; other site 710686016733 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 710686016734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686016735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686016736 homodimer interface [polypeptide binding]; other site 710686016737 catalytic residue [active] 710686016738 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686016739 TIGR03086 family protein; Region: TIGR03086 710686016740 enoyl-CoA hydratase; Provisional; Region: PRK06142 710686016741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686016742 substrate binding site [chemical binding]; other site 710686016743 oxyanion hole (OAH) forming residues; other site 710686016744 trimer interface [polypeptide binding]; other site 710686016745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710686016746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686016747 NAD(P) binding site [chemical binding]; other site 710686016748 active site 710686016749 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686016750 MarR family; Region: MarR; pfam01047 710686016751 MarR family; Region: MarR_2; cl17246 710686016752 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 710686016753 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 710686016754 NAD(P) binding site [chemical binding]; other site 710686016755 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710686016756 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686016757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686016758 catalytic residue [active] 710686016759 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 710686016760 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 710686016761 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 710686016762 Walker A/P-loop; other site 710686016763 ATP binding site [chemical binding]; other site 710686016764 Q-loop/lid; other site 710686016765 ABC transporter signature motif; other site 710686016766 Walker B; other site 710686016767 D-loop; other site 710686016768 H-loop/switch region; other site 710686016769 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710686016770 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686016771 active site 710686016772 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 710686016773 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710686016774 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710686016775 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710686016776 active site 710686016777 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710686016778 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710686016779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686016780 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710686016781 DNA-binding site [nucleotide binding]; DNA binding site 710686016782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710686016783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710686016784 homodimer interface [polypeptide binding]; other site 710686016785 catalytic residue [active] 710686016786 Predicted membrane protein [Function unknown]; Region: COG2246 710686016787 GtrA-like protein; Region: GtrA; pfam04138 710686016788 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710686016789 FAD binding domain; Region: FAD_binding_4; pfam01565 710686016790 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 710686016791 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710686016792 classical (c) SDRs; Region: SDR_c; cd05233 710686016793 NAD(P) binding site [chemical binding]; other site 710686016794 active site 710686016795 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 710686016796 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 710686016797 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710686016798 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710686016799 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710686016800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710686016801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710686016802 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710686016803 active site 710686016804 ATP binding site [chemical binding]; other site 710686016805 substrate binding site [chemical binding]; other site 710686016806 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710686016807 substrate binding site [chemical binding]; other site 710686016808 activation loop (A-loop); other site 710686016809 activation loop (A-loop); other site 710686016810 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686016811 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686016812 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710686016813 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686016814 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686016815 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710686016816 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710686016817 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710686016818 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710686016819 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016820 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710686016821 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710686016822 active site 710686016823 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710686016824 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710686016825 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710686016826 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 710686016827 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 710686016828 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710686016829 acyl-activating enzyme (AAE) consensus motif; other site 710686016830 active site 710686016831 Cutinase; Region: Cutinase; pfam01083 710686016832 Putative esterase; Region: Esterase; pfam00756 710686016833 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710686016834 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 710686016835 Putative esterase; Region: Esterase; pfam00756 710686016836 S-formylglutathione hydrolase; Region: PLN02442 710686016837 Putative esterase; Region: Esterase; pfam00756 710686016838 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 710686016839 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710686016840 active site 710686016841 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710686016842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710686016843 active site 710686016844 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 710686016845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686016846 UDP-galactopyranose mutase; Region: GLF; pfam03275 710686016847 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710686016848 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 710686016849 amidase catalytic site [active] 710686016850 Zn binding residues [ion binding]; other site 710686016851 substrate binding site [chemical binding]; other site 710686016852 LGFP repeat; Region: LGFP; pfam08310 710686016853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686016854 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710686016855 active site 710686016856 motif I; other site 710686016857 motif II; other site 710686016858 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710686016859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686016860 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686016861 putative acyl-acceptor binding pocket; other site 710686016862 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710686016863 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710686016864 putative acyl-acceptor binding pocket; other site 710686016865 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710686016866 Phosphotransferase enzyme family; Region: APH; pfam01636 710686016867 active site 710686016868 ATP binding site [chemical binding]; other site 710686016869 substrate binding site [chemical binding]; other site 710686016870 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710686016871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710686016872 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710686016873 iron-sulfur cluster [ion binding]; other site 710686016874 [2Fe-2S] cluster binding site [ion binding]; other site 710686016875 seryl-tRNA synthetase; Provisional; Region: PRK05431 710686016876 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710686016877 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710686016878 dimer interface [polypeptide binding]; other site 710686016879 active site 710686016880 motif 1; other site 710686016881 motif 2; other site 710686016882 motif 3; other site 710686016883 Septum formation; Region: Septum_form; pfam13845 710686016884 Septum formation; Region: Septum_form; pfam13845 710686016885 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 710686016886 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710686016887 catalytic core [active] 710686016888 prephenate dehydratase; Provisional; Region: PRK11898 710686016889 Prephenate dehydratase; Region: PDT; pfam00800 710686016890 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 710686016891 putative L-Phe binding site [chemical binding]; other site 710686016892 CAAX protease self-immunity; Region: Abi; pfam02517 710686016893 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710686016894 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 710686016895 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 710686016896 putative active site [active] 710686016897 catalytic site [active] 710686016898 putative metal binding site [ion binding]; other site 710686016899 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 710686016900 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710686016901 active site residue [active] 710686016902 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 710686016903 yybP-ykoY leader; Mycsm_06223 710686016904 Predicted membrane protein [Function unknown]; Region: COG2119 710686016905 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710686016906 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710686016907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710686016908 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 710686016909 CopC domain; Region: CopC; pfam04234 710686016910 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 710686016911 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710686016912 DNA binding residues [nucleotide binding] 710686016913 dimer interface [polypeptide binding]; other site 710686016914 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 710686016915 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 710686016916 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710686016917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710686016918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686016919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686016920 DNA polymerase IV; Validated; Region: PRK03858 710686016921 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710686016922 active site 710686016923 DNA binding site [nucleotide binding] 710686016924 hypothetical protein; Provisional; Region: PRK07945 710686016925 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 710686016926 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 710686016927 active site 710686016928 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710686016929 TIGR03086 family protein; Region: TIGR03086 710686016930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686016931 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710686016932 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710686016933 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710686016934 active site 710686016935 NodB motif; other site 710686016936 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710686016937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686016938 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710686016939 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710686016940 active site 710686016941 dimer interface [polypeptide binding]; other site 710686016942 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710686016943 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710686016944 active site 710686016945 FMN binding site [chemical binding]; other site 710686016946 substrate binding site [chemical binding]; other site 710686016947 3Fe-4S cluster binding site [ion binding]; other site 710686016948 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710686016949 domain interface; other site 710686016950 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710686016951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710686016952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710686016953 motif II; other site 710686016954 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710686016955 CoenzymeA binding site [chemical binding]; other site 710686016956 subunit interaction site [polypeptide binding]; other site 710686016957 PHB binding site; other site 710686016958 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710686016959 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 710686016960 Cl- selectivity filter; other site 710686016961 Cl- binding residues [ion binding]; other site 710686016962 pore gating glutamate residue; other site 710686016963 dimer interface [polypeptide binding]; other site 710686016964 H+/Cl- coupling transport residue; other site 710686016965 Cupin; Region: Cupin_1; smart00835 710686016966 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 710686016967 Cupin; Region: Cupin_1; smart00835 710686016968 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 710686016969 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710686016970 dimerization interface [polypeptide binding]; other site 710686016971 DPS ferroxidase diiron center [ion binding]; other site 710686016972 ion pore; other site 710686016973 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710686016974 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710686016975 minor groove reading motif; other site 710686016976 helix-hairpin-helix signature motif; other site 710686016977 active site 710686016978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710686016979 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710686016980 hydrophobic ligand binding site; other site 710686016981 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710686016982 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710686016983 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 710686016984 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 710686016985 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710686016986 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710686016987 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710686016988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686016989 NAD(P) binding site [chemical binding]; other site 710686016990 active site 710686016991 SnoaL-like domain; Region: SnoaL_2; pfam12680 710686016992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686016993 SelR domain; Region: SelR; pfam01641 710686016994 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710686016995 methionine sulfoxide reductase A; Provisional; Region: PRK14054 710686016996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686016997 Cytochrome P450; Region: p450; cl12078 710686016998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686016999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686017000 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710686017001 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686017002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686017003 DNA binding residues [nucleotide binding] 710686017004 dimerization interface [polypeptide binding]; other site 710686017005 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710686017006 Cytochrome P450; Region: p450; cl12078 710686017007 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 710686017008 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 710686017009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710686017010 S-adenosylmethionine binding site [chemical binding]; other site 710686017011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710686017012 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710686017013 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 710686017014 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686017015 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 710686017016 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710686017017 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686017018 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 710686017019 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 710686017020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710686017021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710686017022 active site 710686017023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710686017024 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710686017025 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710686017026 tetramer interface [polypeptide binding]; other site 710686017027 active site 710686017028 Mg2+/Mn2+ binding site [ion binding]; other site 710686017029 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710686017030 classical (c) SDRs; Region: SDR_c; cd05233 710686017031 NAD(P) binding site [chemical binding]; other site 710686017032 active site 710686017033 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 710686017034 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710686017035 NAD binding site [chemical binding]; other site 710686017036 catalytic Zn binding site [ion binding]; other site 710686017037 structural Zn binding site [ion binding]; other site 710686017038 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 710686017039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710686017040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710686017041 catalytic residue [active] 710686017042 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 710686017043 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686017044 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 710686017045 Isochorismatase family; Region: Isochorismatase; pfam00857 710686017046 catalytic triad [active] 710686017047 metal binding site [ion binding]; metal-binding site 710686017048 conserved cis-peptide bond; other site 710686017049 enoyl-CoA hydratase; Provisional; Region: PRK06210 710686017050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686017051 substrate binding site [chemical binding]; other site 710686017052 oxyanion hole (OAH) forming residues; other site 710686017053 trimer interface [polypeptide binding]; other site 710686017054 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710686017055 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710686017056 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710686017057 active site 710686017058 catalytic site [active] 710686017059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686017060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686017061 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686017062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686017063 NAD(P) binding site [chemical binding]; other site 710686017064 active site 710686017065 PAS fold; Region: PAS_3; pfam08447 710686017066 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710686017067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710686017068 MarR family; Region: MarR_2; pfam12802 710686017069 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710686017070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686017071 Walker A/P-loop; other site 710686017072 ATP binding site [chemical binding]; other site 710686017073 Q-loop/lid; other site 710686017074 ABC transporter signature motif; other site 710686017075 Walker B; other site 710686017076 D-loop; other site 710686017077 H-loop/switch region; other site 710686017078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710686017079 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710686017080 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 710686017081 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710686017082 Protein of unknown function, DUF417; Region: DUF417; cl01162 710686017083 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710686017084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710686017085 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 710686017086 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 710686017087 trehalose synthase; Region: treS_nterm; TIGR02456 710686017088 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 710686017089 active site 710686017090 catalytic site [active] 710686017091 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 710686017092 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 710686017093 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 710686017094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710686017095 active site 710686017096 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710686017097 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710686017098 active site 710686017099 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710686017100 substrate binding site [chemical binding]; other site 710686017101 catalytic residues [active] 710686017102 dimer interface [polypeptide binding]; other site 710686017103 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710686017104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710686017105 Walker A/P-loop; other site 710686017106 ATP binding site [chemical binding]; other site 710686017107 Q-loop/lid; other site 710686017108 ABC transporter signature motif; other site 710686017109 Walker B; other site 710686017110 D-loop; other site 710686017111 H-loop/switch region; other site 710686017112 TOBE domain; Region: TOBE_2; pfam08402 710686017113 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710686017114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686017115 dimer interface [polypeptide binding]; other site 710686017116 conserved gate region; other site 710686017117 putative PBP binding loops; other site 710686017118 ABC-ATPase subunit interface; other site 710686017119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686017120 ABC-ATPase subunit interface; other site 710686017121 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710686017122 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710686017123 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 710686017124 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710686017125 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 710686017126 elongation factor G; Reviewed; Region: PRK12740 710686017127 G1 box; other site 710686017128 putative GEF interaction site [polypeptide binding]; other site 710686017129 GTP/Mg2+ binding site [chemical binding]; other site 710686017130 Switch I region; other site 710686017131 G2 box; other site 710686017132 G3 box; other site 710686017133 Switch II region; other site 710686017134 G4 box; other site 710686017135 G5 box; other site 710686017136 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710686017137 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710686017138 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710686017139 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710686017140 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710686017141 active site 710686017142 GAF domain; Region: GAF_2; pfam13185 710686017143 GAF domain; Region: GAF; cl17456 710686017144 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710686017145 ATP binding site [chemical binding]; other site 710686017146 Mg2+ binding site [ion binding]; other site 710686017147 G-X-G motif; other site 710686017148 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710686017149 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686017150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686017151 DNA binding residues [nucleotide binding] 710686017152 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710686017153 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 710686017154 active site 710686017155 catalytic triad [active] 710686017156 calcium binding site [ion binding]; other site 710686017157 L-lactate permease; Region: Lactate_perm; cl00701 710686017158 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710686017159 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 710686017160 L-lactate permease; Region: Lactate_perm; cl00701 710686017161 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686017162 anti sigma factor interaction site; other site 710686017163 regulatory phosphorylation site [posttranslational modification]; other site 710686017164 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 710686017165 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 710686017166 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 710686017167 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 710686017168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710686017169 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 710686017170 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 710686017171 PAS domain S-box; Region: sensory_box; TIGR00229 710686017172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710686017173 putative active site [active] 710686017174 heme pocket [chemical binding]; other site 710686017175 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710686017176 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710686017177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710686017178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686017179 anti sigma factor interaction site; other site 710686017180 regulatory phosphorylation site [posttranslational modification]; other site 710686017181 ANTAR domain; Region: ANTAR; pfam03861 710686017182 galactokinase; Provisional; Region: PRK00555 710686017183 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 710686017184 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 710686017185 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 710686017186 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 710686017187 dimer interface [polypeptide binding]; other site 710686017188 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 710686017189 active site 710686017190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710686017191 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 710686017192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710686017193 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710686017194 Na binding site [ion binding]; other site 710686017195 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 710686017196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710686017197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710686017198 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 710686017199 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710686017200 Protein of unknown function DUF58; Region: DUF58; pfam01882 710686017201 MoxR-like ATPases [General function prediction only]; Region: COG0714 710686017202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686017203 Walker A motif; other site 710686017204 ATP binding site [chemical binding]; other site 710686017205 Walker B motif; other site 710686017206 arginine finger; other site 710686017207 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710686017208 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710686017209 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710686017210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710686017211 substrate binding site [chemical binding]; other site 710686017212 oxyanion hole (OAH) forming residues; other site 710686017213 trimer interface [polypeptide binding]; other site 710686017214 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 710686017215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710686017216 classical (c) SDRs; Region: SDR_c; cd05233 710686017217 NAD(P) binding site [chemical binding]; other site 710686017218 active site 710686017219 RNA polymerase factor sigma-70; Validated; Region: PRK08241 710686017220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686017221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686017222 DNA binding residues [nucleotide binding] 710686017223 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710686017224 Predicted membrane protein [Function unknown]; Region: COG2246 710686017225 GtrA-like protein; Region: GtrA; pfam04138 710686017226 Rhomboid family; Region: Rhomboid; pfam01694 710686017227 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710686017228 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710686017229 active site 710686017230 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710686017231 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710686017232 heme-binding site [chemical binding]; other site 710686017233 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710686017234 Beta-lactamase; Region: Beta-lactamase; pfam00144 710686017235 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686017236 anti sigma factor interaction site; other site 710686017237 regulatory phosphorylation site [posttranslational modification]; other site 710686017238 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710686017239 Response regulator receiver domain; Region: Response_reg; pfam00072 710686017240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686017241 active site 710686017242 phosphorylation site [posttranslational modification] 710686017243 intermolecular recognition site; other site 710686017244 dimerization interface [polypeptide binding]; other site 710686017245 CHASE3 domain; Region: CHASE3; pfam05227 710686017246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710686017247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686017248 dimerization interface [polypeptide binding]; other site 710686017249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686017250 dimer interface [polypeptide binding]; other site 710686017251 phosphorylation site [posttranslational modification] 710686017252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686017253 ATP binding site [chemical binding]; other site 710686017254 Mg2+ binding site [ion binding]; other site 710686017255 G-X-G motif; other site 710686017256 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710686017257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686017258 active site 710686017259 phosphorylation site [posttranslational modification] 710686017260 intermolecular recognition site; other site 710686017261 dimerization interface [polypeptide binding]; other site 710686017262 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710686017263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710686017264 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710686017265 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710686017266 substrate binding pocket [chemical binding]; other site 710686017267 catalytic triad [active] 710686017268 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 710686017269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710686017270 ATP binding site [chemical binding]; other site 710686017271 putative Mg++ binding site [ion binding]; other site 710686017272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710686017273 nucleotide binding region [chemical binding]; other site 710686017274 Helicase associated domain (HA2); Region: HA2; pfam04408 710686017275 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 710686017276 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 710686017277 hypothetical protein; Validated; Region: PRK00029 710686017278 Uncharacterized conserved protein [Function unknown]; Region: COG0397 710686017279 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710686017280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686017281 Cutinase; Region: Cutinase; pfam01083 710686017282 Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345 710686017283 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710686017284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686017285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686017286 DNA binding residues [nucleotide binding] 710686017287 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710686017288 putative FMN binding site [chemical binding]; other site 710686017289 AAA ATPase domain; Region: AAA_16; pfam13191 710686017290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710686017291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710686017292 DNA binding residues [nucleotide binding] 710686017293 dimerization interface [polypeptide binding]; other site 710686017294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710686017295 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710686017296 NAD(P) binding site [chemical binding]; other site 710686017297 active site 710686017298 O-methyltransferase; Region: Methyltransf_2; pfam00891 710686017299 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710686017300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686017301 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710686017302 YCII-related domain; Region: YCII; cl00999 710686017303 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710686017304 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710686017305 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710686017306 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710686017307 putative active site [active] 710686017308 putative metal binding site [ion binding]; other site 710686017309 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 710686017310 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 710686017311 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 710686017312 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710686017313 RNA binding site [nucleotide binding]; other site 710686017314 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 710686017315 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710686017316 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710686017317 PDZ domain; Region: PDZ_2; pfam13180 710686017318 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710686017319 active site 710686017320 catalytic site [active] 710686017321 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710686017322 active site 2 [active] 710686017323 active site 1 [active] 710686017324 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710686017325 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710686017326 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710686017327 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710686017328 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 710686017329 putative NAD(P) binding site [chemical binding]; other site 710686017330 catalytic Zn binding site [ion binding]; other site 710686017331 structural Zn binding site [ion binding]; other site 710686017332 acyl-CoA synthetase; Validated; Region: PRK07788 710686017333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710686017334 acyl-activating enzyme (AAE) consensus motif; other site 710686017335 AMP binding site [chemical binding]; other site 710686017336 active site 710686017337 CoA binding site [chemical binding]; other site 710686017338 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 710686017339 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710686017340 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710686017341 FtsX-like permease family; Region: FtsX; pfam02687 710686017342 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710686017343 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686017344 Walker A/P-loop; other site 710686017345 ATP binding site [chemical binding]; other site 710686017346 Q-loop/lid; other site 710686017347 ABC transporter signature motif; other site 710686017348 Walker B; other site 710686017349 D-loop; other site 710686017350 H-loop/switch region; other site 710686017351 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 710686017352 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710686017353 Walker A/P-loop; other site 710686017354 ATP binding site [chemical binding]; other site 710686017355 Q-loop/lid; other site 710686017356 ABC transporter signature motif; other site 710686017357 Walker B; other site 710686017358 D-loop; other site 710686017359 H-loop/switch region; other site 710686017360 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710686017361 active site 710686017362 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710686017363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710686017364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710686017365 active site 710686017366 phosphorylation site [posttranslational modification] 710686017367 intermolecular recognition site; other site 710686017368 dimerization interface [polypeptide binding]; other site 710686017369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710686017370 DNA binding site [nucleotide binding] 710686017371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710686017372 dimerization interface [polypeptide binding]; other site 710686017373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710686017374 dimer interface [polypeptide binding]; other site 710686017375 phosphorylation site [posttranslational modification] 710686017376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710686017377 ATP binding site [chemical binding]; other site 710686017378 Mg2+ binding site [ion binding]; other site 710686017379 G-X-G motif; other site 710686017380 Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional; Region: PTZ00139 710686017381 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017382 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017383 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017384 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710686017385 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017386 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017387 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017388 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710686017389 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710686017390 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710686017391 ligand binding site [chemical binding]; other site 710686017392 flexible hinge region; other site 710686017393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686017394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686017395 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710686017396 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 710686017397 thioredoxin 2; Provisional; Region: PRK10996 710686017398 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686017399 catalytic residues [active] 710686017400 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 710686017401 Clp amino terminal domain; Region: Clp_N; pfam02861 710686017402 Clp amino terminal domain; Region: Clp_N; pfam02861 710686017403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686017404 Walker A motif; other site 710686017405 ATP binding site [chemical binding]; other site 710686017406 Walker B motif; other site 710686017407 arginine finger; other site 710686017408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710686017409 Walker A motif; other site 710686017410 ATP binding site [chemical binding]; other site 710686017411 Walker B motif; other site 710686017412 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710686017413 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 710686017414 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 710686017415 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 710686017416 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710686017417 HSP70 interaction site [polypeptide binding]; other site 710686017418 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710686017419 substrate binding site [polypeptide binding]; other site 710686017420 dimer interface [polypeptide binding]; other site 710686017421 GrpE; Region: GrpE; pfam01025 710686017422 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710686017423 dimer interface [polypeptide binding]; other site 710686017424 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710686017425 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710686017426 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 710686017427 nucleotide binding site [chemical binding]; other site 710686017428 NEF interaction site [polypeptide binding]; other site 710686017429 SBD interface [polypeptide binding]; other site 710686017430 CodY GAF-like domain; Region: CodY; pfam06018 710686017431 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710686017432 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 710686017433 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710686017434 anti sigma factor interaction site; other site 710686017435 regulatory phosphorylation site [posttranslational modification]; other site 710686017436 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 710686017437 PemK-like protein; Region: PemK; pfam02452 710686017438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686017439 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710686017440 cyclase homology domain; Region: CHD; cd07302 710686017441 nucleotidyl binding site; other site 710686017442 metal binding site [ion binding]; metal-binding site 710686017443 dimer interface [polypeptide binding]; other site 710686017444 replicative DNA helicase; Region: DnaB; TIGR00665 710686017445 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710686017446 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710686017447 Walker A motif; other site 710686017448 ATP binding site [chemical binding]; other site 710686017449 Walker B motif; other site 710686017450 DNA binding loops [nucleotide binding] 710686017451 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710686017452 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710686017453 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710686017454 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 710686017455 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710686017456 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710686017457 dimer interface [polypeptide binding]; other site 710686017458 ssDNA binding site [nucleotide binding]; other site 710686017459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710686017460 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 710686017461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710686017462 TAP-like protein; Region: Abhydrolase_4; pfam08386 710686017463 Predicted integral membrane protein [Function unknown]; Region: COG5650 710686017464 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710686017465 Transglycosylase; Region: Transgly; pfam00912 710686017466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710686017467 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710686017468 Predicted transcriptional regulators [Transcription]; Region: COG1695 710686017469 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710686017470 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 710686017471 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 710686017472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710686017473 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710686017474 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710686017475 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710686017476 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710686017477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710686017478 DNA-binding site [nucleotide binding]; DNA binding site 710686017479 FCD domain; Region: FCD; pfam07729 710686017480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710686017481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710686017482 substrate binding pocket [chemical binding]; other site 710686017483 membrane-bound complex binding site; other site 710686017484 hinge residues; other site 710686017485 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710686017486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710686017487 dimer interface [polypeptide binding]; other site 710686017488 conserved gate region; other site 710686017489 putative PBP binding loops; other site 710686017490 ABC-ATPase subunit interface; other site 710686017491 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710686017492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710686017493 Walker A/P-loop; other site 710686017494 ATP binding site [chemical binding]; other site 710686017495 Q-loop/lid; other site 710686017496 ABC transporter signature motif; other site 710686017497 Walker B; other site 710686017498 D-loop; other site 710686017499 H-loop/switch region; other site 710686017500 MarR family; Region: MarR; pfam01047 710686017501 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 710686017502 short chain dehydrogenase; Provisional; Region: PRK08219 710686017503 classical (c) SDRs; Region: SDR_c; cd05233 710686017504 NAD(P) binding site [chemical binding]; other site 710686017505 active site 710686017506 Secretory lipase; Region: LIP; pfam03583 710686017507 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 710686017508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686017509 active site 710686017510 HIGH motif; other site 710686017511 nucleotide binding site [chemical binding]; other site 710686017512 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710686017513 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686017514 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710686017515 active site 710686017516 KMSKS motif; other site 710686017517 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 710686017518 tRNA binding surface [nucleotide binding]; other site 710686017519 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710686017520 hypothetical protein; Validated; Region: PRK00228 710686017521 H+ Antiporter protein; Region: 2A0121; TIGR00900 710686017522 TIGR03084 family protein; Region: TIGR03084 710686017523 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710686017524 Wyosine base formation; Region: Wyosine_form; pfam08608 710686017525 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 710686017526 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 710686017527 active site 710686017528 NTP binding site [chemical binding]; other site 710686017529 metal binding triad [ion binding]; metal-binding site 710686017530 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 710686017531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710686017532 Zn2+ binding site [ion binding]; other site 710686017533 Mg2+ binding site [ion binding]; other site 710686017534 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 710686017535 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710686017536 active site 710686017537 Ap6A binding site [chemical binding]; other site 710686017538 nudix motif; other site 710686017539 metal binding site [ion binding]; metal-binding site 710686017540 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 710686017541 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 710686017542 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 710686017543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710686017544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710686017545 DNA binding residues [nucleotide binding] 710686017546 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710686017547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710686017548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710686017549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710686017550 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710686017551 catalytic residues [active] 710686017552 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710686017553 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710686017554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710686017555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710686017556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710686017557 active site 710686017558 metal binding site [ion binding]; metal-binding site 710686017559 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 710686017560 ParB-like nuclease domain; Region: ParB; smart00470 710686017561 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710686017562 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710686017563 Magnesium ion binding site [ion binding]; other site 710686017564 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 710686017565 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 710686017566 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 710686017567 G-X-X-G motif; other site 710686017568 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 710686017569 RxxxH motif; other site 710686017570 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 710686017571 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 710686017572 hypothetical protein; Validated; Region: PRK00041 710686017573 ribonuclease P; Reviewed; Region: rnpA; PRK00588 710686017574 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399