-- dump date 20140619_153435 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710685000001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685000002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685000003 active site 710685000004 ATP binding site [chemical binding]; other site 710685000005 substrate binding site [chemical binding]; other site 710685000006 activation loop (A-loop); other site 710685000007 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 710685000008 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710685000009 mce related protein; Region: MCE; pfam02470 710685000010 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685000011 mce related protein; Region: MCE; pfam02470 710685000012 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685000013 mce related protein; Region: MCE; pfam02470 710685000014 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685000015 mce related protein; Region: MCE; pfam02470 710685000016 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710685000017 mce related protein; Region: MCE; pfam02470 710685000018 mce related protein; Region: MCE; pfam02470 710685000019 Permease; Region: Permease; pfam02405 710685000020 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685000021 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685000022 Permease; Region: Permease; pfam02405 710685000023 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 710685000024 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685000025 active site 710685000026 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685000027 active site 710685000028 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710685000029 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 710685000030 nickel binding site [ion binding]; other site 710685000031 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 710685000032 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 710685000033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685000034 catalytic loop [active] 710685000035 iron binding site [ion binding]; other site 710685000036 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 710685000037 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 710685000038 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685000039 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710685000040 SLBB domain; Region: SLBB; pfam10531 710685000041 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 710685000042 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685000043 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685000044 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685000045 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685000046 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 710685000047 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 710685000048 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710685000049 phosphoenolpyruvate synthase; Validated; Region: PRK06464 710685000050 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 710685000051 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710685000052 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710685000053 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 710685000054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685000055 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000056 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 710685000057 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710685000058 dimer interface [polypeptide binding]; other site 710685000059 PYR/PP interface [polypeptide binding]; other site 710685000060 TPP binding site [chemical binding]; other site 710685000061 substrate binding site [chemical binding]; other site 710685000062 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710685000063 Domain of unknown function; Region: EKR; pfam10371 710685000064 4Fe-4S binding domain; Region: Fer4_6; pfam12837 710685000065 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000066 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 710685000067 TPP-binding site [chemical binding]; other site 710685000068 dimer interface [polypeptide binding]; other site 710685000069 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 710685000070 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 710685000071 putative active site [active] 710685000072 putative FMN binding site [chemical binding]; other site 710685000073 putative substrate binding site [chemical binding]; other site 710685000074 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685000075 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685000076 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685000077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685000078 Ligand Binding Site [chemical binding]; other site 710685000079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685000080 Ligand Binding Site [chemical binding]; other site 710685000081 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710685000082 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710685000083 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 710685000084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685000085 active site 710685000086 motif I; other site 710685000087 motif II; other site 710685000088 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710685000089 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710685000090 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710685000091 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710685000092 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 710685000093 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710685000094 putative substrate binding site [chemical binding]; other site 710685000095 putative ATP binding site [chemical binding]; other site 710685000096 4Fe-4S binding domain; Region: Fer4; cl02805 710685000097 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710685000098 dimer interface [polypeptide binding]; other site 710685000099 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685000100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000102 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 710685000103 NAD(P) binding site [chemical binding]; other site 710685000104 active site 710685000105 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 710685000106 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685000107 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685000108 classical (c) SDRs; Region: SDR_c; cd05233 710685000109 NAD(P) binding site [chemical binding]; other site 710685000110 active site 710685000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710685000112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000114 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710685000115 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685000116 short chain dehydrogenase; Provisional; Region: PRK12827 710685000117 classical (c) SDRs; Region: SDR_c; cd05233 710685000118 NAD(P) binding site [chemical binding]; other site 710685000119 active site 710685000120 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685000121 classical (c) SDRs; Region: SDR_c; cd05233 710685000122 NAD(P) binding site [chemical binding]; other site 710685000123 active site 710685000124 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685000125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000127 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685000128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000129 NAD(P) binding site [chemical binding]; other site 710685000130 active site 710685000131 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685000132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000133 NAD(P) binding site [chemical binding]; other site 710685000134 active site 710685000135 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685000136 classical (c) SDRs; Region: SDR_c; cd05233 710685000137 NAD(P) binding site [chemical binding]; other site 710685000138 active site 710685000139 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000140 Cytochrome P450; Region: p450; cl12078 710685000141 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 710685000142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685000144 DNA-binding site [nucleotide binding]; DNA binding site 710685000145 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710685000146 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 710685000147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000148 NAD(P) binding site [chemical binding]; other site 710685000149 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685000150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000151 NAD(P) binding site [chemical binding]; other site 710685000152 active site 710685000153 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710685000154 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710685000155 FAD binding pocket [chemical binding]; other site 710685000156 FAD binding motif [chemical binding]; other site 710685000157 phosphate binding motif [ion binding]; other site 710685000158 beta-alpha-beta structure motif; other site 710685000159 NAD binding pocket [chemical binding]; other site 710685000160 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710685000161 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685000162 catalytic loop [active] 710685000163 iron binding site [ion binding]; other site 710685000164 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710685000165 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685000166 putative di-iron ligands [ion binding]; other site 710685000167 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 710685000168 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710685000169 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685000170 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685000171 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710685000172 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685000173 Walker A/P-loop; other site 710685000174 ATP binding site [chemical binding]; other site 710685000175 Q-loop/lid; other site 710685000176 ABC transporter signature motif; other site 710685000177 Walker B; other site 710685000178 D-loop; other site 710685000179 H-loop/switch region; other site 710685000180 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710685000181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710685000182 active site 710685000183 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710685000184 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710685000185 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710685000186 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710685000187 putative NADP binding site [chemical binding]; other site 710685000188 active site 710685000189 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685000190 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710685000191 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 710685000192 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685000193 classical (c) SDRs; Region: SDR_c; cd05233 710685000194 NAD(P) binding site [chemical binding]; other site 710685000195 active site 710685000196 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710685000197 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685000198 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 710685000199 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000200 Cytochrome P450; Region: p450; cl12078 710685000201 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 710685000202 Flavodoxin; Region: Flavodoxin_1; pfam00258 710685000203 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 710685000204 FAD binding pocket [chemical binding]; other site 710685000205 FAD binding motif [chemical binding]; other site 710685000206 catalytic residues [active] 710685000207 NAD binding pocket [chemical binding]; other site 710685000208 phosphate binding motif [ion binding]; other site 710685000209 beta-alpha-beta structure motif; other site 710685000210 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710685000211 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710685000212 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710685000213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685000214 catalytic loop [active] 710685000215 iron binding site [ion binding]; other site 710685000216 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710685000217 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710685000218 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710685000219 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710685000220 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710685000221 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710685000222 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710685000223 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 710685000224 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685000225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685000226 Walker A motif; other site 710685000227 ATP binding site [chemical binding]; other site 710685000228 Walker B motif; other site 710685000229 arginine finger; other site 710685000230 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 710685000231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685000232 S-adenosylmethionine binding site [chemical binding]; other site 710685000233 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710685000234 classical (c) SDRs; Region: SDR_c; cd05233 710685000235 NAD(P) binding site [chemical binding]; other site 710685000236 active site 710685000237 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685000238 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685000239 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685000240 NAD(P) binding site [chemical binding]; other site 710685000241 catalytic residues [active] 710685000242 lipid-transfer protein; Provisional; Region: PRK07855 710685000243 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685000244 active site 710685000245 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685000246 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685000247 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685000248 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685000249 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685000250 [2Fe-2S] cluster binding site [ion binding]; other site 710685000251 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685000252 hydrophobic ligand binding site; other site 710685000253 short chain dehydrogenase; Provisional; Region: PRK07791 710685000254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000255 NAD(P) binding site [chemical binding]; other site 710685000256 active site 710685000257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000258 enoyl-CoA hydratase; Provisional; Region: PRK12478 710685000259 substrate binding site [chemical binding]; other site 710685000260 oxyanion hole (OAH) forming residues; other site 710685000261 trimer interface [polypeptide binding]; other site 710685000262 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710685000263 putative hydrophobic ligand binding site [chemical binding]; other site 710685000264 protein interface [polypeptide binding]; other site 710685000265 gate; other site 710685000266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000267 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685000268 active site 710685000269 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685000270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000271 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000272 active site 710685000273 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685000274 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000275 Cytochrome P450; Region: p450; cl12078 710685000276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000277 Cytochrome P450; Region: p450; cl12078 710685000278 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000279 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000280 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000281 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000282 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710685000283 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685000284 active site 710685000285 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000286 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000287 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000288 Cytochrome P450; Region: p450; cl12078 710685000289 Cytochrome P450; Region: p450; cl12078 710685000290 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000291 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000292 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000293 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685000295 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710685000296 active site 710685000297 metal binding site [ion binding]; metal-binding site 710685000298 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000299 Cytochrome P450; Region: p450; cl12078 710685000300 enoyl-CoA hydratase; Provisional; Region: PRK06494 710685000301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000302 substrate binding site [chemical binding]; other site 710685000303 oxyanion hole (OAH) forming residues; other site 710685000304 trimer interface [polypeptide binding]; other site 710685000305 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685000306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685000307 AMP binding site [chemical binding]; other site 710685000308 active site 710685000309 acyl-activating enzyme (AAE) consensus motif; other site 710685000310 CoA binding site [chemical binding]; other site 710685000311 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710685000312 Strictosidine synthase; Region: Str_synth; pfam03088 710685000313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685000314 classical (c) SDRs; Region: SDR_c; cd05233 710685000315 NAD(P) binding site [chemical binding]; other site 710685000316 active site 710685000317 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685000318 active site 710685000319 catalytic site [active] 710685000320 short chain dehydrogenase; Provisional; Region: PRK07890 710685000321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000322 NAD(P) binding site [chemical binding]; other site 710685000323 active site 710685000324 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685000325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685000326 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 710685000327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685000328 active site 710685000329 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685000330 active site 710685000331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000332 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685000333 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685000334 active site 710685000335 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000336 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000337 active site 710685000338 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685000339 active site 710685000340 catalytic site [active] 710685000341 succinic semialdehyde dehydrogenase; Region: PLN02278 710685000342 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710685000343 tetramerization interface [polypeptide binding]; other site 710685000344 NAD(P) binding site [chemical binding]; other site 710685000345 catalytic residues [active] 710685000346 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685000347 active site 2 [active] 710685000348 active site 1 [active] 710685000349 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685000350 classical (c) SDRs; Region: SDR_c; cd05233 710685000351 NAD(P) binding site [chemical binding]; other site 710685000352 active site 710685000353 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685000354 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685000355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000356 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685000357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000358 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000360 active site 710685000361 Phosphotransferase enzyme family; Region: APH; pfam01636 710685000362 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710685000363 active site 710685000364 ATP binding site [chemical binding]; other site 710685000365 substrate binding site [chemical binding]; other site 710685000366 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685000367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685000368 dimerization interface [polypeptide binding]; other site 710685000369 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685000370 cyclase homology domain; Region: CHD; cd07302 710685000371 nucleotidyl binding site; other site 710685000372 metal binding site [ion binding]; metal-binding site 710685000373 dimer interface [polypeptide binding]; other site 710685000374 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685000375 classical (c) SDRs; Region: SDR_c; cd05233 710685000376 NAD(P) binding site [chemical binding]; other site 710685000377 active site 710685000378 short chain dehydrogenase; Provisional; Region: PRK07060 710685000379 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685000380 NAD(P) binding site [chemical binding]; other site 710685000381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000382 active site 710685000383 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685000384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000385 substrate binding site [chemical binding]; other site 710685000386 oxyanion hole (OAH) forming residues; other site 710685000387 trimer interface [polypeptide binding]; other site 710685000388 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000389 Cytochrome P450; Region: p450; cl12078 710685000390 enoyl-CoA hydratase; Provisional; Region: PRK08290 710685000391 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000392 substrate binding site [chemical binding]; other site 710685000393 oxyanion hole (OAH) forming residues; other site 710685000394 trimer interface [polypeptide binding]; other site 710685000395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000396 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685000397 active site 710685000398 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685000399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000400 substrate binding site [chemical binding]; other site 710685000401 oxyanion hole (OAH) forming residues; other site 710685000402 trimer interface [polypeptide binding]; other site 710685000403 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685000404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000405 substrate binding site [chemical binding]; other site 710685000406 oxyanion hole (OAH) forming residues; other site 710685000407 trimer interface [polypeptide binding]; other site 710685000408 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710685000409 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685000410 FMN binding site [chemical binding]; other site 710685000411 substrate binding site [chemical binding]; other site 710685000412 putative catalytic residue [active] 710685000413 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685000414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000415 substrate binding site [chemical binding]; other site 710685000416 oxyanion hole (OAH) forming residues; other site 710685000417 trimer interface [polypeptide binding]; other site 710685000418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710685000419 E3 interaction surface; other site 710685000420 lipoyl attachment site [posttranslational modification]; other site 710685000421 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710685000422 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710685000423 tetramer interface [polypeptide binding]; other site 710685000424 TPP-binding site [chemical binding]; other site 710685000425 heterodimer interface [polypeptide binding]; other site 710685000426 phosphorylation loop region [posttranslational modification] 710685000427 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710685000428 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710685000429 alpha subunit interface [polypeptide binding]; other site 710685000430 TPP binding site [chemical binding]; other site 710685000431 heterodimer interface [polypeptide binding]; other site 710685000432 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685000433 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685000434 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685000435 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685000436 thiolase; Provisional; Region: PRK06158 710685000437 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685000438 active site 710685000439 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685000440 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685000441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685000442 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710685000443 dimer interaction site [polypeptide binding]; other site 710685000444 substrate-binding tunnel; other site 710685000445 active site 710685000446 catalytic site [active] 710685000447 substrate binding site [chemical binding]; other site 710685000448 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685000449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685000451 classical (c) SDRs; Region: SDR_c; cd05233 710685000452 NAD(P) binding site [chemical binding]; other site 710685000453 active site 710685000454 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685000455 AMP-binding enzyme; Region: AMP-binding; pfam00501 710685000456 acyl-activating enzyme (AAE) consensus motif; other site 710685000457 AMP binding site [chemical binding]; other site 710685000458 active site 710685000459 CoA binding site [chemical binding]; other site 710685000460 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685000461 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710685000462 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685000463 active site 710685000464 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685000465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000466 NAD(P) binding site [chemical binding]; other site 710685000467 active site 710685000468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000470 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685000471 classical (c) SDRs; Region: SDR_c; cd05233 710685000472 NAD(P) binding site [chemical binding]; other site 710685000473 active site 710685000474 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710685000475 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685000476 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685000477 active site 710685000478 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685000479 catalytic triad [active] 710685000480 dimer interface [polypeptide binding]; other site 710685000481 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685000482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000483 NAD(P) binding site [chemical binding]; other site 710685000484 active site 710685000485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000486 NAD(P) binding site [chemical binding]; other site 710685000487 active site 710685000488 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685000489 classical (c) SDRs; Region: SDR_c; cd05233 710685000490 NAD(P) binding site [chemical binding]; other site 710685000491 active site 710685000492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000493 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710685000494 DNA-binding interface [nucleotide binding]; DNA binding site 710685000495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685000496 Ligand Binding Site [chemical binding]; other site 710685000497 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710685000498 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710685000499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710685000500 synthetase active site [active] 710685000501 NTP binding site [chemical binding]; other site 710685000502 metal binding site [ion binding]; metal-binding site 710685000503 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 710685000504 heme-binding site [chemical binding]; other site 710685000505 MarR family; Region: MarR_2; cl17246 710685000506 Uncharacterized conserved protein [Function unknown]; Region: COG3189 710685000507 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 710685000508 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 710685000509 THF binding site; other site 710685000510 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 710685000511 substrate binding site [chemical binding]; other site 710685000512 THF binding site; other site 710685000513 zinc-binding site [ion binding]; other site 710685000514 aconitate hydratase; Validated; Region: PRK09277 710685000515 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710685000516 substrate binding site [chemical binding]; other site 710685000517 ligand binding site [chemical binding]; other site 710685000518 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 710685000519 substrate binding site [chemical binding]; other site 710685000520 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685000521 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685000522 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 710685000523 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710685000524 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000525 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 710685000526 L-aspartate oxidase; Provisional; Region: PRK06175 710685000527 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710685000528 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 710685000529 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 710685000530 putative Iron-sulfur protein interface [polypeptide binding]; other site 710685000531 proximal heme binding site [chemical binding]; other site 710685000532 distal heme binding site [chemical binding]; other site 710685000533 putative dimer interface [polypeptide binding]; other site 710685000534 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 710685000535 OsmC-like protein; Region: OsmC; cl00767 710685000536 GTP cyclohydrolase I; Provisional; Region: PLN03044 710685000537 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 710685000538 active site 710685000539 Predicted membrane protein [Function unknown]; Region: COG2259 710685000540 dimerization interface [polypeptide binding]; other site 710685000541 putative DNA binding site [nucleotide binding]; other site 710685000542 Predicted transcriptional regulator [Transcription]; Region: COG2345 710685000543 Helix-turn-helix domain; Region: HTH_20; pfam12840 710685000544 putative Zn2+ binding site [ion binding]; other site 710685000545 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710685000546 putative active site [active] 710685000547 transaldolase; Provisional; Region: PRK03903 710685000548 catalytic residue [active] 710685000549 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710685000550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685000551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685000552 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710685000553 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710685000554 D-pathway; other site 710685000555 Putative ubiquinol binding site [chemical binding]; other site 710685000556 Low-spin heme (heme b) binding site [chemical binding]; other site 710685000557 Putative water exit pathway; other site 710685000558 Binuclear center (heme o3/CuB) [ion binding]; other site 710685000559 K-pathway; other site 710685000560 Putative proton exit pathway; other site 710685000561 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 710685000562 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 710685000563 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000564 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 710685000565 Predicted transcriptional regulator [Transcription]; Region: COG2345 710685000566 Helix-turn-helix domain; Region: HTH_20; pfam12840 710685000567 putative DNA binding site [nucleotide binding]; other site 710685000568 putative Zn2+ binding site [ion binding]; other site 710685000569 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710685000570 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710685000571 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685000572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685000573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685000574 DNA binding residues [nucleotide binding] 710685000575 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 710685000576 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 710685000577 tetramer interface [polypeptide binding]; other site 710685000578 heme binding pocket [chemical binding]; other site 710685000579 NADPH binding site [chemical binding]; other site 710685000580 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685000581 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685000582 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685000583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685000584 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710685000585 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710685000586 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710685000587 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710685000588 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710685000589 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685000590 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685000591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000592 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685000593 active site 710685000594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000596 active site 710685000597 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685000598 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685000599 active site 2 [active] 710685000600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710685000601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710685000602 metal binding site [ion binding]; metal-binding site 710685000603 active site 710685000604 I-site; other site 710685000605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710685000606 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710685000607 SmpB-tmRNA interface; other site 710685000608 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 710685000609 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 710685000610 FtsX-like permease family; Region: FtsX; pfam02687 710685000611 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 710685000612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685000613 Walker A/P-loop; other site 710685000614 ATP binding site [chemical binding]; other site 710685000615 Q-loop/lid; other site 710685000616 ABC transporter signature motif; other site 710685000617 Walker B; other site 710685000618 D-loop; other site 710685000619 H-loop/switch region; other site 710685000620 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710685000621 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710685000622 peptide chain release factor 2; Validated; Region: prfB; PRK00578 710685000623 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710685000624 RF-1 domain; Region: RF-1; pfam00472 710685000625 ferredoxin-NADP+ reductase; Region: PLN02852 710685000626 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710685000627 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 710685000628 active site 710685000629 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685000630 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685000631 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685000632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000634 active site 710685000635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000637 active site 710685000638 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 710685000639 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 710685000640 NADP binding site [chemical binding]; other site 710685000641 dimer interface [polypeptide binding]; other site 710685000642 Predicted esterase [General function prediction only]; Region: COG0627 710685000643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685000647 active site 710685000648 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685000649 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 710685000650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685000651 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710685000652 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685000653 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685000654 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710685000655 active site 710685000656 catalytic residues [active] 710685000657 metal binding site [ion binding]; metal-binding site 710685000658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685000661 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685000662 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685000663 active site 710685000664 Phosphotransferase enzyme family; Region: APH; pfam01636 710685000665 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685000666 putative active site [active] 710685000667 putative substrate binding site [chemical binding]; other site 710685000668 ATP binding site [chemical binding]; other site 710685000669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685000670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685000671 S-adenosylmethionine binding site [chemical binding]; other site 710685000672 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685000673 YceI-like domain; Region: YceI; pfam04264 710685000674 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710685000675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685000676 active site 710685000677 phosphorylation site [posttranslational modification] 710685000678 intermolecular recognition site; other site 710685000679 dimerization interface [polypeptide binding]; other site 710685000680 NADH dehydrogenase subunit A; Validated; Region: PRK07928 710685000681 NADH dehydrogenase subunit B; Validated; Region: PRK06411 710685000682 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 710685000683 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 710685000684 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 710685000685 NADH dehydrogenase subunit D; Validated; Region: PRK06075 710685000686 NADH dehydrogenase subunit E; Validated; Region: PRK07539 710685000687 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 710685000688 putative dimer interface [polypeptide binding]; other site 710685000689 [2Fe-2S] cluster binding site [ion binding]; other site 710685000690 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 710685000691 SLBB domain; Region: SLBB; pfam10531 710685000692 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710685000693 NADH dehydrogenase subunit G; Validated; Region: PRK07860 710685000694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685000695 catalytic loop [active] 710685000696 iron binding site [ion binding]; other site 710685000697 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 710685000698 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685000699 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685000700 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 710685000701 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 710685000702 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 710685000703 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 710685000704 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000705 4Fe-4S binding domain; Region: Fer4; pfam00037 710685000706 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 710685000707 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 710685000708 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 710685000709 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 710685000710 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710685000711 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710685000712 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 710685000713 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 710685000714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710685000715 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 710685000716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710685000717 enoyl-CoA hydratase; Provisional; Region: PRK06190 710685000718 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685000719 substrate binding site [chemical binding]; other site 710685000720 oxyanion hole (OAH) forming residues; other site 710685000721 trimer interface [polypeptide binding]; other site 710685000722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685000723 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 710685000724 putative di-iron ligands [ion binding]; other site 710685000725 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685000726 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710685000727 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 710685000728 Di-iron ligands [ion binding]; other site 710685000729 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 710685000730 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 710685000731 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710685000732 Di-iron ligands [ion binding]; other site 710685000733 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 710685000734 acyl-CoA synthetase; Validated; Region: PRK05850 710685000735 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710685000736 acyl-activating enzyme (AAE) consensus motif; other site 710685000737 active site 710685000738 Cytochrome P450; Region: p450; cl12078 710685000739 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685000740 Phosphopantetheine attachment site; Region: PP-binding; cl09936 710685000741 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710685000742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685000743 acyl-activating enzyme (AAE) consensus motif; other site 710685000744 AMP binding site [chemical binding]; other site 710685000745 active site 710685000746 CoA binding site [chemical binding]; other site 710685000747 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710685000748 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685000749 Walker A/P-loop; other site 710685000750 ATP binding site [chemical binding]; other site 710685000751 Q-loop/lid; other site 710685000752 ABC transporter signature motif; other site 710685000753 Walker B; other site 710685000754 D-loop; other site 710685000755 H-loop/switch region; other site 710685000756 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685000757 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685000758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685000759 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710685000760 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685000761 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710685000762 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710685000763 active site 710685000764 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710685000765 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710685000766 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 710685000767 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 710685000768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685000769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685000770 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685000771 putative active site [active] 710685000772 putative substrate binding site [chemical binding]; other site 710685000773 ATP binding site [chemical binding]; other site 710685000774 Phosphotransferase enzyme family; Region: APH; pfam01636 710685000775 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710685000776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685000777 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685000778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685000779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685000780 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685000781 Putative exonuclease, RdgC; Region: RdgC; cl01122 710685000782 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710685000783 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685000784 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710685000785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685000786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685000787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685000788 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685000789 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710685000790 NAD(P) binding site [chemical binding]; other site 710685000791 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 710685000792 putative catalytic site [active] 710685000793 putative metal binding site [ion binding]; other site 710685000794 putative phosphate binding site [ion binding]; other site 710685000795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685000796 heat shock protein 90; Provisional; Region: PRK05218 710685000797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685000798 ATP binding site [chemical binding]; other site 710685000799 Mg2+ binding site [ion binding]; other site 710685000800 G-X-G motif; other site 710685000801 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685000802 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685000803 homodimer interface [polypeptide binding]; other site 710685000804 active site 710685000805 TDP-binding site; other site 710685000806 acceptor substrate-binding pocket; other site 710685000807 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685000808 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685000809 acyl-activating enzyme (AAE) consensus motif; other site 710685000810 AMP binding site [chemical binding]; other site 710685000811 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685000812 Condensation domain; Region: Condensation; pfam00668 710685000813 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685000814 Condensation domain; Region: Condensation; pfam00668 710685000815 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685000816 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685000817 acyl-activating enzyme (AAE) consensus motif; other site 710685000818 AMP binding site [chemical binding]; other site 710685000819 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685000820 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710685000821 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 710685000822 putative NAD(P) binding site [chemical binding]; other site 710685000823 active site 710685000824 putative substrate binding site [chemical binding]; other site 710685000825 Condensation domain; Region: Condensation; pfam00668 710685000826 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685000827 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685000828 acyl-activating enzyme (AAE) consensus motif; other site 710685000829 AMP binding site [chemical binding]; other site 710685000830 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685000831 Condensation domain; Region: Condensation; pfam00668 710685000832 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685000833 Condensation domain; Region: Condensation; pfam00668 710685000834 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685000835 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685000836 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685000837 acyl-activating enzyme (AAE) consensus motif; other site 710685000838 AMP binding site [chemical binding]; other site 710685000839 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685000840 Condensation domain; Region: Condensation; pfam00668 710685000841 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685000842 Condensation domain; Region: Condensation; pfam00668 710685000843 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685000844 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685000845 MbtH-like protein; Region: MbtH; pfam03621 710685000846 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685000847 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685000848 homodimer interface [polypeptide binding]; other site 710685000849 active site 710685000850 TDP-binding site; other site 710685000851 acceptor substrate-binding pocket; other site 710685000852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685000853 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710685000854 Walker A/P-loop; other site 710685000855 ATP binding site [chemical binding]; other site 710685000856 Q-loop/lid; other site 710685000857 ABC transporter signature motif; other site 710685000858 Walker B; other site 710685000859 D-loop; other site 710685000860 H-loop/switch region; other site 710685000861 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685000862 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685000863 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685000864 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685000865 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710685000866 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 710685000867 metal-binding site 710685000868 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 710685000869 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 710685000870 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 710685000871 NADP binding site [chemical binding]; other site 710685000872 active site 710685000873 putative substrate binding site [chemical binding]; other site 710685000874 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 710685000875 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 710685000876 NADP-binding site; other site 710685000877 homotetramer interface [polypeptide binding]; other site 710685000878 substrate binding site [chemical binding]; other site 710685000879 homodimer interface [polypeptide binding]; other site 710685000880 active site 710685000881 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 710685000882 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 710685000883 trimer interface [polypeptide binding]; other site 710685000884 active site 710685000885 substrate binding site [chemical binding]; other site 710685000886 CoA binding site [chemical binding]; other site 710685000887 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000889 NAD(P) binding site [chemical binding]; other site 710685000890 active site 710685000891 WbqC-like protein family; Region: WbqC; pfam08889 710685000892 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685000893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685000894 S-adenosylmethionine binding site [chemical binding]; other site 710685000895 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710685000896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685000897 S-adenosylmethionine binding site [chemical binding]; other site 710685000898 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710685000899 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 710685000900 Ligand binding site; other site 710685000901 Putative Catalytic site; other site 710685000902 DXD motif; other site 710685000903 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 710685000904 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 710685000905 inhibitor-cofactor binding pocket; inhibition site 710685000906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685000907 catalytic residue [active] 710685000908 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685000909 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685000910 homodimer interface [polypeptide binding]; other site 710685000911 active site 710685000912 TDP-binding site; other site 710685000913 acceptor substrate-binding pocket; other site 710685000914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685000916 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685000917 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685000918 homodimer interface [polypeptide binding]; other site 710685000919 active site 710685000920 TDP-binding site; other site 710685000921 acceptor substrate-binding pocket; other site 710685000922 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685000923 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685000924 homodimer interface [polypeptide binding]; other site 710685000925 active site 710685000926 TDP-binding site; other site 710685000927 acceptor substrate-binding pocket; other site 710685000928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685000929 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685000930 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685000931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685000932 NAD(P) binding site [chemical binding]; other site 710685000933 active site 710685000934 Transport protein; Region: actII; TIGR00833 710685000935 Transport protein; Region: actII; TIGR00833 710685000936 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710685000937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685000938 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685000939 Putative sensor; Region: Sensor; pfam13796 710685000940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685000941 Histidine kinase; Region: HisKA_3; pfam07730 710685000942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685000943 ATP binding site [chemical binding]; other site 710685000944 Mg2+ binding site [ion binding]; other site 710685000945 G-X-G motif; other site 710685000946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685000947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685000948 active site 710685000949 phosphorylation site [posttranslational modification] 710685000950 intermolecular recognition site; other site 710685000951 dimerization interface [polypeptide binding]; other site 710685000952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685000953 DNA binding residues [nucleotide binding] 710685000954 dimerization interface [polypeptide binding]; other site 710685000955 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 710685000956 hypothetical protein; Validated; Region: PRK00068 710685000957 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 710685000958 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 710685000959 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710685000960 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710685000961 Uncharacterized conserved protein [Function unknown]; Region: COG5282 710685000962 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710685000963 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710685000964 ABC1 family; Region: ABC1; pfam03109 710685000965 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710685000966 active site 710685000967 ATP binding site [chemical binding]; other site 710685000968 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710685000969 Family description; Region: UvrD_C_2; pfam13538 710685000970 HRDC domain; Region: HRDC; pfam00570 710685000971 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710685000972 catalytic residues [active] 710685000973 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 710685000974 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 710685000975 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 710685000976 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 710685000977 putative NADH binding site [chemical binding]; other site 710685000978 putative active site [active] 710685000979 nudix motif; other site 710685000980 putative metal binding site [ion binding]; other site 710685000981 Ion channel; Region: Ion_trans_2; pfam07885 710685000982 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 710685000983 TrkA-N domain; Region: TrkA_N; pfam02254 710685000984 Predicted membrane protein [Function unknown]; Region: COG4270 710685000985 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710685000986 Part of AAA domain; Region: AAA_19; pfam13245 710685000987 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710685000988 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710685000989 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710685000990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685000991 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710685000992 catalytic site [active] 710685000993 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710685000994 active site 710685000995 DNA binding site [nucleotide binding] 710685000996 TIGR02569 family protein; Region: TIGR02569_actnb 710685000997 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 710685000998 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 710685000999 ATP binding site [chemical binding]; other site 710685001000 substrate interface [chemical binding]; other site 710685001001 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685001002 active site residue [active] 710685001003 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 710685001004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001006 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 710685001007 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710685001008 dinuclear metal binding motif [ion binding]; other site 710685001009 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710685001010 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710685001011 ATP binding site [chemical binding]; other site 710685001012 Mg++ binding site [ion binding]; other site 710685001013 motif III; other site 710685001014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685001015 nucleotide binding region [chemical binding]; other site 710685001016 ATP-binding site [chemical binding]; other site 710685001017 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710685001018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685001019 P-loop; other site 710685001020 Magnesium ion binding site [ion binding]; other site 710685001021 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 710685001022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685001023 Magnesium ion binding site [ion binding]; other site 710685001024 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685001025 catalytic core [active] 710685001026 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710685001027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710685001028 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710685001029 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710685001030 Transcription factor WhiB; Region: Whib; pfam02467 710685001031 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 710685001032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710685001033 Histidine kinase; Region: HisKA_2; pfam07568 710685001034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685001035 ATP binding site [chemical binding]; other site 710685001036 Mg2+ binding site [ion binding]; other site 710685001037 G-X-G motif; other site 710685001038 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685001039 carboxyltransferase (CT) interaction site; other site 710685001040 biotinylation site [posttranslational modification]; other site 710685001041 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 710685001042 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710685001043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685001044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685001045 DNA binding residues [nucleotide binding] 710685001046 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 710685001047 putative deacylase active site [active] 710685001048 short chain dehydrogenase; Provisional; Region: PRK08278 710685001049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685001050 NAD(P) binding site [chemical binding]; other site 710685001051 active site 710685001052 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685001053 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685001054 NAD binding site [chemical binding]; other site 710685001055 catalytic Zn binding site [ion binding]; other site 710685001056 substrate binding site [chemical binding]; other site 710685001057 structural Zn binding site [ion binding]; other site 710685001058 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 710685001059 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685001060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685001061 substrate binding site [chemical binding]; other site 710685001062 oxyanion hole (OAH) forming residues; other site 710685001063 trimer interface [polypeptide binding]; other site 710685001064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001066 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710685001067 Uncharacterized conserved protein [Function unknown]; Region: COG2135 710685001068 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 710685001069 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 710685001070 hinge; other site 710685001071 active site 710685001072 Predicted GTPases [General function prediction only]; Region: COG1162 710685001073 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 710685001074 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710685001075 GTP/Mg2+ binding site [chemical binding]; other site 710685001076 G4 box; other site 710685001077 G5 box; other site 710685001078 G1 box; other site 710685001079 Switch I region; other site 710685001080 G2 box; other site 710685001081 G3 box; other site 710685001082 Switch II region; other site 710685001083 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 710685001084 putative active site [active] 710685001085 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710685001086 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685001087 putative di-iron ligands [ion binding]; other site 710685001088 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710685001089 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710685001090 FAD binding pocket [chemical binding]; other site 710685001091 FAD binding motif [chemical binding]; other site 710685001092 phosphate binding motif [ion binding]; other site 710685001093 beta-alpha-beta structure motif; other site 710685001094 NAD binding pocket [chemical binding]; other site 710685001095 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710685001096 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685001097 catalytic loop [active] 710685001098 iron binding site [ion binding]; other site 710685001099 BCCT family transporter; Region: BCCT; pfam02028 710685001100 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685001101 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685001102 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685001103 hydrophobic ligand binding site; other site 710685001104 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 710685001105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710685001106 ATP binding site [chemical binding]; other site 710685001107 putative Mg++ binding site [ion binding]; other site 710685001108 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710685001109 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 710685001110 30S subunit binding site; other site 710685001111 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 710685001112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685001113 active site 710685001114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 710685001115 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 710685001116 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710685001117 iron-sulfur cluster [ion binding]; other site 710685001118 [2Fe-2S] cluster binding site [ion binding]; other site 710685001119 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710685001120 lipoprotein LpqB; Provisional; Region: PRK13616 710685001121 Sporulation and spore germination; Region: Germane; pfam10646 710685001122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685001123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685001124 dimerization interface [polypeptide binding]; other site 710685001125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685001126 dimer interface [polypeptide binding]; other site 710685001127 phosphorylation site [posttranslational modification] 710685001128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685001129 ATP binding site [chemical binding]; other site 710685001130 Mg2+ binding site [ion binding]; other site 710685001131 G-X-G motif; other site 710685001132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685001133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685001134 active site 710685001135 phosphorylation site [posttranslational modification] 710685001136 intermolecular recognition site; other site 710685001137 dimerization interface [polypeptide binding]; other site 710685001138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685001139 DNA binding site [nucleotide binding] 710685001140 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 710685001141 putative active site [active] 710685001142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685001143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685001144 active site 710685001145 ATP binding site [chemical binding]; other site 710685001146 substrate binding site [chemical binding]; other site 710685001147 activation loop (A-loop); other site 710685001148 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 710685001149 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710685001150 DNA binding site [nucleotide binding] 710685001151 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685001152 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685001153 phosphopeptide binding site; other site 710685001154 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 710685001155 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 710685001156 TMP-binding site; other site 710685001157 ATP-binding site [chemical binding]; other site 710685001158 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710685001159 Secretory lipase; Region: LIP; pfam03583 710685001160 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 710685001161 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 710685001162 homotetramer interface [polypeptide binding]; other site 710685001163 ligand binding site [chemical binding]; other site 710685001164 catalytic site [active] 710685001165 NAD binding site [chemical binding]; other site 710685001166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001168 Rubredoxin [Energy production and conversion]; Region: COG1773 710685001169 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710685001170 iron binding site [ion binding]; other site 710685001171 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710685001172 Rubredoxin; Region: Rubredoxin; pfam00301 710685001173 iron binding site [ion binding]; other site 710685001174 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 710685001175 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710685001176 Di-iron ligands [ion binding]; other site 710685001177 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710685001178 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685001179 putative active site [active] 710685001180 amino acid transporter; Region: 2A0306; TIGR00909 710685001181 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 710685001182 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710685001183 hypothetical protein; Provisional; Region: PRK07236 710685001184 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 710685001185 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710685001186 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710685001187 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 710685001188 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 710685001189 active site 710685001190 substrate binding site [chemical binding]; other site 710685001191 metal binding site [ion binding]; metal-binding site 710685001192 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 710685001193 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 710685001194 Transcription factor WhiB; Region: Whib; pfam02467 710685001195 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 710685001196 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 710685001197 dimer interface [polypeptide binding]; other site 710685001198 substrate binding site [chemical binding]; other site 710685001199 phosphate binding site [ion binding]; other site 710685001200 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 710685001201 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 710685001202 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 710685001203 putative FMN binding site [chemical binding]; other site 710685001204 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 710685001205 nudix motif; other site 710685001206 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 710685001207 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 710685001208 active site 710685001209 Substrate binding site; other site 710685001210 Mg++ binding site; other site 710685001211 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710685001212 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710685001213 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710685001214 Probable Catalytic site; other site 710685001215 metal-binding site 710685001216 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 710685001217 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 710685001218 NADP binding site [chemical binding]; other site 710685001219 active site 710685001220 putative substrate binding site [chemical binding]; other site 710685001221 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710685001222 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710685001223 TIGR03089 family protein; Region: TIGR03089 710685001224 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710685001225 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710685001226 Multicopper oxidase; Region: Cu-oxidase; pfam00394 710685001227 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710685001228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685001229 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 710685001230 FAD binding site [chemical binding]; other site 710685001231 homotetramer interface [polypeptide binding]; other site 710685001232 substrate binding pocket [chemical binding]; other site 710685001233 catalytic base [active] 710685001234 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 710685001235 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 710685001236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685001237 Predicted membrane protein [Function unknown]; Region: COG2246 710685001238 GtrA-like protein; Region: GtrA; pfam04138 710685001239 Bacterial PH domain; Region: DUF304; pfam03703 710685001240 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 710685001241 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 710685001242 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 710685001243 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685001244 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685001245 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685001246 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 710685001247 putative active site [active] 710685001248 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710685001249 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710685001250 active site residue [active] 710685001251 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710685001252 active site residue [active] 710685001253 Fe-S metabolism associated domain; Region: SufE; cl00951 710685001254 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685001255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685001256 NAD(P) binding site [chemical binding]; other site 710685001257 active site 710685001258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685001259 Cytochrome P450; Region: p450; cl12078 710685001260 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 710685001261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685001262 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710685001263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710685001264 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685001265 carboxyltransferase (CT) interaction site; other site 710685001266 biotinylation site [posttranslational modification]; other site 710685001267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685001268 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710685001269 NAD(P) binding site [chemical binding]; other site 710685001270 active site 710685001271 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 710685001272 metal-binding site 710685001273 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685001274 anti sigma factor interaction site; other site 710685001275 regulatory phosphorylation site [posttranslational modification]; other site 710685001276 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685001277 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 710685001278 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 710685001279 active site 710685001280 DNA binding site [nucleotide binding] 710685001281 Int/Topo IB signature motif; other site 710685001282 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710685001283 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710685001284 Restriction endonuclease; Region: Mrr_cat; pfam04471 710685001285 L-lysine aminotransferase; Provisional; Region: PRK08297 710685001286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685001287 inhibitor-cofactor binding pocket; inhibition site 710685001288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001289 catalytic residue [active] 710685001290 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710685001291 AsnC family; Region: AsnC_trans_reg; pfam01037 710685001292 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 710685001293 aldehyde dehydrogenase family 7 member; Region: PLN02315 710685001294 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 710685001295 tetrameric interface [polypeptide binding]; other site 710685001296 NAD binding site [chemical binding]; other site 710685001297 catalytic residues [active] 710685001298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685001301 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 710685001302 ATP binding site [chemical binding]; other site 710685001303 putative Mg++ binding site [ion binding]; other site 710685001304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685001305 nucleotide binding region [chemical binding]; other site 710685001306 ATP-binding site [chemical binding]; other site 710685001307 DEAD/H associated; Region: DEAD_assoc; pfam08494 710685001308 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685001309 FMN binding site [chemical binding]; other site 710685001310 putative catalytic residue [active] 710685001311 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710685001312 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 710685001313 putative DNA binding site [nucleotide binding]; other site 710685001314 catalytic residue [active] 710685001315 putative H2TH interface [polypeptide binding]; other site 710685001316 putative catalytic residues [active] 710685001317 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710685001318 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710685001319 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710685001320 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685001321 putative di-iron ligands [ion binding]; other site 710685001322 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710685001323 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710685001324 FAD binding pocket [chemical binding]; other site 710685001325 FAD binding motif [chemical binding]; other site 710685001326 phosphate binding motif [ion binding]; other site 710685001327 beta-alpha-beta structure motif; other site 710685001328 NAD binding pocket [chemical binding]; other site 710685001329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685001330 catalytic loop [active] 710685001331 iron binding site [ion binding]; other site 710685001332 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 710685001333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001334 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685001335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685001336 substrate binding site [chemical binding]; other site 710685001337 oxyanion hole (OAH) forming residues; other site 710685001338 trimer interface [polypeptide binding]; other site 710685001339 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685001340 classical (c) SDRs; Region: SDR_c; cd05233 710685001341 NAD(P) binding site [chemical binding]; other site 710685001342 active site 710685001343 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 710685001344 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 710685001345 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 710685001346 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 710685001347 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 710685001348 probable active site [active] 710685001349 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710685001350 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 710685001351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685001352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685001353 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685001354 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710685001355 putative active site pocket [active] 710685001356 dimerization interface [polypeptide binding]; other site 710685001357 putative catalytic residue [active] 710685001358 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710685001359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001361 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710685001362 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 710685001363 metal binding site [ion binding]; metal-binding site 710685001364 putative dimer interface [polypeptide binding]; other site 710685001365 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 710685001366 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710685001367 metal binding site [ion binding]; metal-binding site 710685001368 purine nucleoside phosphorylase; Provisional; Region: PRK08202 710685001369 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 710685001370 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710685001371 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710685001372 MarR family; Region: MarR_2; pfam12802 710685001373 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 710685001374 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 710685001375 active site 710685001376 substrate binding site [chemical binding]; other site 710685001377 metal binding site [ion binding]; metal-binding site 710685001378 putative succinate dehydrogenase; Reviewed; Region: PRK12842 710685001379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685001380 active site 710685001381 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710685001382 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685001383 active site 710685001384 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685001385 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685001386 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685001387 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685001388 putative acyl-acceptor binding pocket; other site 710685001389 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685001390 Permease; Region: Permease; pfam02405 710685001391 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 710685001392 adenosine deaminase; Provisional; Region: PRK09358 710685001393 active site 710685001394 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710685001395 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710685001396 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710685001397 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 710685001398 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710685001399 active site 710685001400 catalytic motif [active] 710685001401 Zn binding site [ion binding]; other site 710685001402 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 710685001403 putative Iron-sulfur protein interface [polypeptide binding]; other site 710685001404 putative proximal heme binding site [chemical binding]; other site 710685001405 putative SdhD-like interface [polypeptide binding]; other site 710685001406 putative distal heme binding site [chemical binding]; other site 710685001407 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 710685001408 putative Iron-sulfur protein interface [polypeptide binding]; other site 710685001409 putative proximal heme binding site [chemical binding]; other site 710685001410 putative SdhC-like subunit interface [polypeptide binding]; other site 710685001411 putative distal heme binding site [chemical binding]; other site 710685001412 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 710685001413 L-aspartate oxidase; Provisional; Region: PRK06175 710685001414 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710685001415 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 710685001416 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710685001417 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685001418 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 710685001419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685001420 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710685001421 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685001422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685001423 Ligand Binding Site [chemical binding]; other site 710685001424 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685001425 Ligand Binding Site [chemical binding]; other site 710685001426 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 710685001427 Spore germination protein; Region: Spore_permease; cl17796 710685001428 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710685001429 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685001430 NAD(P) binding site [chemical binding]; other site 710685001431 catalytic residues [active] 710685001432 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710685001433 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710685001434 putative DNA binding site [nucleotide binding]; other site 710685001435 putative Zn2+ binding site [ion binding]; other site 710685001436 AsnC family; Region: AsnC_trans_reg; pfam01037 710685001437 hypothetical protein; Provisional; Region: PRK06541 710685001438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685001439 inhibitor-cofactor binding pocket; inhibition site 710685001440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001441 catalytic residue [active] 710685001442 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 710685001443 Strictosidine synthase; Region: Str_synth; pfam03088 710685001444 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710685001445 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710685001446 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 710685001447 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 710685001448 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 710685001449 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710685001450 active site 710685001451 HIGH motif; other site 710685001452 dimer interface [polypeptide binding]; other site 710685001453 KMSKS motif; other site 710685001454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685001455 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 710685001456 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 710685001457 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 710685001458 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710685001459 homodimer interface [polypeptide binding]; other site 710685001460 substrate-cofactor binding pocket; other site 710685001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001462 catalytic residue [active] 710685001463 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 710685001464 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 710685001465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685001466 S-adenosylmethionine binding site [chemical binding]; other site 710685001467 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 710685001468 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 710685001469 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710685001470 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 710685001471 homodimer interface [polypeptide binding]; other site 710685001472 NADP binding site [chemical binding]; other site 710685001473 substrate binding site [chemical binding]; other site 710685001474 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710685001475 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 710685001476 active site 710685001477 FMN binding site [chemical binding]; other site 710685001478 substrate binding site [chemical binding]; other site 710685001479 putative catalytic residue [active] 710685001480 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 710685001481 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685001482 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685001483 phosphopeptide binding site; other site 710685001484 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685001485 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685001486 phosphopeptide binding site; other site 710685001487 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 710685001488 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710685001489 Walker A/P-loop; other site 710685001490 ATP binding site [chemical binding]; other site 710685001491 Q-loop/lid; other site 710685001492 ABC transporter signature motif; other site 710685001493 Walker B; other site 710685001494 D-loop; other site 710685001495 H-loop/switch region; other site 710685001496 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710685001497 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685001498 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710685001499 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710685001500 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710685001501 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710685001502 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710685001503 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710685001504 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 710685001505 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 710685001506 G1 box; other site 710685001507 GTP/Mg2+ binding site [chemical binding]; other site 710685001508 G2 box; other site 710685001509 Switch I region; other site 710685001510 G3 box; other site 710685001511 Switch II region; other site 710685001512 G4 box; other site 710685001513 G5 box; other site 710685001514 Protein of unknown function (DUF742); Region: DUF742; pfam05331 710685001515 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 710685001516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685001518 ATP binding site [chemical binding]; other site 710685001519 Mg2+ binding site [ion binding]; other site 710685001520 G-X-G motif; other site 710685001521 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 710685001522 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710685001523 FMN binding site [chemical binding]; other site 710685001524 dimer interface [polypeptide binding]; other site 710685001525 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 710685001526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685001527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685001528 putative substrate translocation pore; other site 710685001529 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 710685001530 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710685001531 active site 710685001532 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710685001533 generic binding surface II; other site 710685001534 generic binding surface I; other site 710685001535 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685001536 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685001537 active site 710685001538 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685001539 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710685001540 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685001541 Ligand Binding Site [chemical binding]; other site 710685001542 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685001543 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710685001544 dimer interaction site [polypeptide binding]; other site 710685001545 substrate-binding tunnel; other site 710685001546 active site 710685001547 catalytic site [active] 710685001548 substrate binding site [chemical binding]; other site 710685001549 short chain dehydrogenase; Provisional; Region: PRK07201 710685001550 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 710685001551 putative NAD(P) binding site [chemical binding]; other site 710685001552 active site 710685001553 putative substrate binding site [chemical binding]; other site 710685001554 classical (c) SDRs; Region: SDR_c; cd05233 710685001555 NAD(P) binding site [chemical binding]; other site 710685001556 active site 710685001557 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 710685001558 active site 710685001559 DNA Polymerase Y-family; Region: PolY_like; cd03468 710685001560 DNA binding site [nucleotide binding] 710685001561 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 710685001562 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710685001563 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710685001564 classical (c) SDRs; Region: SDR_c; cd05233 710685001565 short chain dehydrogenase; Provisional; Region: PRK05650 710685001566 NAD(P) binding site [chemical binding]; other site 710685001567 active site 710685001568 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710685001569 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685001570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685001571 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710685001572 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685001573 DNA binding residues [nucleotide binding] 710685001574 putative dimer interface [polypeptide binding]; other site 710685001575 GMP synthase; Reviewed; Region: guaA; PRK00074 710685001576 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 710685001577 AMP/PPi binding site [chemical binding]; other site 710685001578 candidate oxyanion hole; other site 710685001579 catalytic triad [active] 710685001580 potential glutamine specificity residues [chemical binding]; other site 710685001581 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 710685001582 ATP Binding subdomain [chemical binding]; other site 710685001583 Ligand Binding sites [chemical binding]; other site 710685001584 Dimerization subdomain; other site 710685001585 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710685001586 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710685001587 active site 710685001588 non-prolyl cis peptide bond; other site 710685001589 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685001590 Na binding site [ion binding]; other site 710685001591 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 710685001592 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685001593 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710685001594 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710685001595 dimer interface [polypeptide binding]; other site 710685001596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001597 catalytic residue [active] 710685001598 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 710685001599 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 710685001600 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710685001601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685001602 motif II; other site 710685001603 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710685001604 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710685001605 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710685001606 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710685001607 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710685001608 PhoU domain; Region: PhoU; pfam01895 710685001609 PhoU domain; Region: PhoU; pfam01895 710685001610 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710685001611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685001612 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685001613 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 710685001614 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685001615 phosphate binding site [ion binding]; other site 710685001616 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 710685001617 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685001618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 710685001619 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710685001620 active site 710685001621 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 710685001622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685001623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685001624 DNA binding residues [nucleotide binding] 710685001625 Transcription factor WhiB; Region: Whib; pfam02467 710685001626 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 710685001627 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685001628 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710685001629 putative NAD(P) binding site [chemical binding]; other site 710685001630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685001631 dimerization interface [polypeptide binding]; other site 710685001632 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685001633 cyclase homology domain; Region: CHD; cd07302 710685001634 nucleotidyl binding site; other site 710685001635 metal binding site [ion binding]; metal-binding site 710685001636 dimer interface [polypeptide binding]; other site 710685001637 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710685001638 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710685001639 ring oligomerisation interface [polypeptide binding]; other site 710685001640 ATP/Mg binding site [chemical binding]; other site 710685001641 stacking interactions; other site 710685001642 hinge regions; other site 710685001643 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710685001644 oligomerisation interface [polypeptide binding]; other site 710685001645 mobile loop; other site 710685001646 roof hairpin; other site 710685001647 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685001648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685001649 UGMP family protein; Validated; Region: PRK09604 710685001650 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 710685001651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685001652 Coenzyme A binding pocket [chemical binding]; other site 710685001653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710685001654 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 710685001655 Glycoprotease family; Region: Peptidase_M22; pfam00814 710685001656 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 710685001657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685001658 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685001659 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685001660 alanine racemase; Reviewed; Region: alr; PRK00053 710685001661 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 710685001662 active site 710685001663 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710685001664 dimer interface [polypeptide binding]; other site 710685001665 substrate binding site [chemical binding]; other site 710685001666 catalytic residues [active] 710685001667 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 710685001668 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 710685001669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001670 catalytic residue [active] 710685001671 Uncharacterized conserved protein [Function unknown]; Region: COG0062 710685001672 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 710685001673 putative substrate binding site [chemical binding]; other site 710685001674 putative ATP binding site [chemical binding]; other site 710685001675 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710685001676 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710685001677 glutaminase active site [active] 710685001678 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710685001679 dimer interface [polypeptide binding]; other site 710685001680 active site 710685001681 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710685001682 dimer interface [polypeptide binding]; other site 710685001683 active site 710685001684 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685001685 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710685001686 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685001687 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710685001688 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710685001689 ATP binding site [chemical binding]; other site 710685001690 Mg++ binding site [ion binding]; other site 710685001691 motif III; other site 710685001692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685001693 nucleotide binding region [chemical binding]; other site 710685001694 ATP-binding site [chemical binding]; other site 710685001695 Winged helix-turn helix; Region: HTH_29; pfam13551 710685001696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710685001697 Integrase core domain; Region: rve; pfam00665 710685001698 Integrase core domain; Region: rve_3; pfam13683 710685001699 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685001700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685001701 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685001702 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685001703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685001704 active site 710685001705 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 710685001706 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 710685001707 active site 710685001708 substrate binding site [chemical binding]; other site 710685001709 metal binding site [ion binding]; metal-binding site 710685001710 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 710685001711 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 710685001712 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710685001713 23S rRNA interface [nucleotide binding]; other site 710685001714 L3 interface [polypeptide binding]; other site 710685001715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 710685001716 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710685001717 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 710685001718 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710685001719 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685001720 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710685001721 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685001723 Walker A motif; other site 710685001724 ATP binding site [chemical binding]; other site 710685001725 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 710685001726 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710685001727 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710685001728 active site 710685001729 catalytic residues [active] 710685001730 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710685001731 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710685001732 CGNR zinc finger; Region: zf-CGNR; pfam11706 710685001733 EamA-like transporter family; Region: EamA; pfam00892 710685001734 EamA-like transporter family; Region: EamA; pfam00892 710685001735 Cutinase; Region: Cutinase; pfam01083 710685001736 Cutinase; Region: Cutinase; pfam01083 710685001737 Cutinase; Region: Cutinase; pfam01083 710685001738 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710685001739 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 710685001740 dimerization interface 3.5A [polypeptide binding]; other site 710685001741 active site 710685001742 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 710685001743 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710685001744 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710685001745 alphaNTD homodimer interface [polypeptide binding]; other site 710685001746 alphaNTD - beta interaction site [polypeptide binding]; other site 710685001747 alphaNTD - beta' interaction site [polypeptide binding]; other site 710685001748 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 710685001749 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710685001750 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710685001751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710685001752 RNA binding surface [nucleotide binding]; other site 710685001753 30S ribosomal protein S11; Validated; Region: PRK05309 710685001754 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 710685001755 30S ribosomal protein S13; Region: bact_S13; TIGR03631 710685001756 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710685001757 rRNA binding site [nucleotide binding]; other site 710685001758 predicted 30S ribosome binding site; other site 710685001759 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710685001760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685001761 active site 710685001762 phosphorylation site [posttranslational modification] 710685001763 intermolecular recognition site; other site 710685001764 dimerization interface [polypeptide binding]; other site 710685001765 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710685001766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685001767 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685001768 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685001769 ligand binding site [chemical binding]; other site 710685001770 flexible hinge region; other site 710685001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685001772 ATP binding site [chemical binding]; other site 710685001773 Mg2+ binding site [ion binding]; other site 710685001774 G-X-G motif; other site 710685001775 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710685001776 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685001777 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710685001778 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 710685001779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 710685001780 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 710685001781 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 710685001782 NAD binding site [chemical binding]; other site 710685001783 substrate binding site [chemical binding]; other site 710685001784 homodimer interface [polypeptide binding]; other site 710685001785 active site 710685001786 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 710685001787 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710685001788 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710685001789 tetrameric interface [polypeptide binding]; other site 710685001790 NAD binding site [chemical binding]; other site 710685001791 catalytic residues [active] 710685001792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685001793 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 710685001794 substrate binding pocket [chemical binding]; other site 710685001795 FAD binding site [chemical binding]; other site 710685001796 catalytic base [active] 710685001797 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685001798 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 710685001799 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685001800 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685001801 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710685001802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685001803 motif II; other site 710685001804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685001805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685001806 active site 710685001807 phosphorylation site [posttranslational modification] 710685001808 intermolecular recognition site; other site 710685001809 dimerization interface [polypeptide binding]; other site 710685001810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685001811 DNA binding residues [nucleotide binding] 710685001812 dimerization interface [polypeptide binding]; other site 710685001813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685001814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710685001815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685001816 Histidine kinase; Region: HisKA_3; pfam07730 710685001817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685001818 ATP binding site [chemical binding]; other site 710685001819 Mg2+ binding site [ion binding]; other site 710685001820 G-X-G motif; other site 710685001821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685001822 MarR family; Region: MarR; pfam01047 710685001823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685001824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710685001825 active site 710685001826 metal binding site [ion binding]; metal-binding site 710685001827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685001828 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 710685001829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685001830 homodimer interface [polypeptide binding]; other site 710685001831 catalytic residue [active] 710685001832 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 710685001833 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685001834 active site 710685001835 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710685001836 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685001837 PYR/PP interface [polypeptide binding]; other site 710685001838 dimer interface [polypeptide binding]; other site 710685001839 TPP binding site [chemical binding]; other site 710685001840 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 710685001841 TPP-binding site [chemical binding]; other site 710685001842 Putative zinc-finger; Region: zf-HC2; pfam13490 710685001843 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710685001844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685001845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685001846 DNA binding residues [nucleotide binding] 710685001847 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710685001848 active site 710685001849 adenylate kinase; Reviewed; Region: adk; PRK00279 710685001850 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710685001851 AMP-binding site [chemical binding]; other site 710685001852 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710685001853 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710685001854 SecY translocase; Region: SecY; pfam00344 710685001855 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685001856 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685001857 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685001858 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685001859 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685001860 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685001861 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685001862 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710685001863 nucleotide binding site [chemical binding]; other site 710685001864 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 710685001865 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 710685001866 NAD binding site [chemical binding]; other site 710685001867 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 710685001868 intersubunit interface [polypeptide binding]; other site 710685001869 active site 710685001870 Zn2+ binding site [ion binding]; other site 710685001871 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 710685001872 tandem repeat interface [polypeptide binding]; other site 710685001873 oligomer interface [polypeptide binding]; other site 710685001874 active site residues [active] 710685001875 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 710685001876 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 710685001877 tandem repeat interface [polypeptide binding]; other site 710685001878 oligomer interface [polypeptide binding]; other site 710685001879 active site residues [active] 710685001880 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685001881 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 710685001882 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 710685001883 23S rRNA binding site [nucleotide binding]; other site 710685001884 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710685001885 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710685001886 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710685001887 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710685001888 5S rRNA interface [nucleotide binding]; other site 710685001889 L27 interface [polypeptide binding]; other site 710685001890 23S rRNA interface [nucleotide binding]; other site 710685001891 L5 interface [polypeptide binding]; other site 710685001892 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710685001893 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710685001894 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710685001895 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 710685001896 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 710685001897 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710685001898 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710685001899 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710685001900 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 710685001901 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 710685001902 RNA binding site [nucleotide binding]; other site 710685001903 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 710685001904 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710685001905 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710685001906 beta-lactamase TEM; Provisional; Region: PRK15442 710685001907 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710685001908 Sulfatase; Region: Sulfatase; pfam00884 710685001909 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 710685001910 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 710685001911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001913 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685001914 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 710685001915 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710685001916 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710685001917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685001918 GAF domain; Region: GAF; pfam01590 710685001919 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710685001920 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710685001921 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710685001922 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 710685001923 catalytic residue [active] 710685001924 putative FPP diphosphate binding site; other site 710685001925 putative FPP binding hydrophobic cleft; other site 710685001926 dimer interface [polypeptide binding]; other site 710685001927 putative IPP diphosphate binding site; other site 710685001928 hypothetical protein; Provisional; Region: PRK07208 710685001929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685001930 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 710685001931 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 710685001932 putative translocon interaction site; other site 710685001933 23S rRNA interface [nucleotide binding]; other site 710685001934 signal recognition particle (SRP54) interaction site; other site 710685001935 L23 interface [polypeptide binding]; other site 710685001936 trigger factor interaction site; other site 710685001937 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710685001938 23S rRNA interface [nucleotide binding]; other site 710685001939 5S rRNA interface [nucleotide binding]; other site 710685001940 putative antibiotic binding site [chemical binding]; other site 710685001941 L25 interface [polypeptide binding]; other site 710685001942 L27 interface [polypeptide binding]; other site 710685001943 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710685001944 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 710685001945 G-X-X-G motif; other site 710685001946 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710685001947 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710685001948 putative translocon binding site; other site 710685001949 protein-rRNA interface [nucleotide binding]; other site 710685001950 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 710685001951 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710685001952 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710685001953 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710685001954 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 710685001955 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 710685001956 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 710685001957 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 710685001958 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685001959 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685001960 Carboxylesterase family; Region: COesterase; pfam00135 710685001961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685001962 substrate binding pocket [chemical binding]; other site 710685001963 catalytic triad [active] 710685001964 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685001965 Cytochrome P450; Region: p450; cl12078 710685001966 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685001967 Cytochrome P450; Region: p450; cl12078 710685001968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685001969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685001971 putative substrate translocation pore; other site 710685001972 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710685001973 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 710685001974 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685001975 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 710685001976 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710685001977 Probable Catalytic site; other site 710685001978 metal-binding site 710685001979 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 710685001980 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 710685001981 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685001982 phosphate binding site [ion binding]; other site 710685001983 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 710685001984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685001985 FeS/SAM binding site; other site 710685001986 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710685001987 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 710685001988 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685001989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685001990 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 710685001991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685001992 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710685001993 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710685001994 putative dimer interface [polypeptide binding]; other site 710685001995 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685001996 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685001997 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710685001998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710685001999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685002000 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710685002001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685002002 putative DNA binding site [nucleotide binding]; other site 710685002003 putative Zn2+ binding site [ion binding]; other site 710685002004 AsnC family; Region: AsnC_trans_reg; pfam01037 710685002005 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710685002006 Amidinotransferase; Region: Amidinotransf; pfam02274 710685002007 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 710685002008 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685002009 inhibitor-cofactor binding pocket; inhibition site 710685002010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685002011 catalytic residue [active] 710685002012 amino acid transporter; Region: 2A0306; TIGR00909 710685002013 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 710685002014 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685002015 Ligand Binding Site [chemical binding]; other site 710685002016 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685002017 classical (c) SDRs; Region: SDR_c; cd05233 710685002018 NAD(P) binding site [chemical binding]; other site 710685002019 active site 710685002020 arginine deiminase; Provisional; Region: PRK01388 710685002021 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 710685002022 Short C-terminal domain; Region: SHOCT; pfam09851 710685002023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002024 putative substrate translocation pore; other site 710685002025 Cutinase; Region: Cutinase; pfam01083 710685002026 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710685002027 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 710685002028 putative NAD(P) binding site [chemical binding]; other site 710685002029 putative substrate binding site [chemical binding]; other site 710685002030 catalytic Zn binding site [ion binding]; other site 710685002031 structural Zn binding site [ion binding]; other site 710685002032 elongation factor Tu; Reviewed; Region: PRK00049 710685002033 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 710685002034 G1 box; other site 710685002035 GEF interaction site [polypeptide binding]; other site 710685002036 GTP/Mg2+ binding site [chemical binding]; other site 710685002037 Switch I region; other site 710685002038 G2 box; other site 710685002039 G3 box; other site 710685002040 Switch II region; other site 710685002041 G4 box; other site 710685002042 G5 box; other site 710685002043 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710685002044 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 710685002045 Antibiotic Binding Site [chemical binding]; other site 710685002046 elongation factor G; Reviewed; Region: PRK00007 710685002047 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 710685002048 G1 box; other site 710685002049 putative GEF interaction site [polypeptide binding]; other site 710685002050 GTP/Mg2+ binding site [chemical binding]; other site 710685002051 Switch I region; other site 710685002052 G2 box; other site 710685002053 G3 box; other site 710685002054 Switch II region; other site 710685002055 G4 box; other site 710685002056 G5 box; other site 710685002057 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710685002058 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710685002059 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710685002060 30S ribosomal protein S7; Validated; Region: PRK05302 710685002061 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710685002062 S17 interaction site [polypeptide binding]; other site 710685002063 S8 interaction site; other site 710685002064 16S rRNA interaction site [nucleotide binding]; other site 710685002065 streptomycin interaction site [chemical binding]; other site 710685002066 23S rRNA interaction site [nucleotide binding]; other site 710685002067 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710685002068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002070 WHG domain; Region: WHG; pfam13305 710685002071 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710685002072 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710685002073 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710685002074 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710685002075 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685002076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685002077 substrate binding site [chemical binding]; other site 710685002078 oxyanion hole (OAH) forming residues; other site 710685002079 trimer interface [polypeptide binding]; other site 710685002080 PaaX-like protein; Region: PaaX; pfam07848 710685002081 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 710685002082 enoyl-CoA hydratase; Provisional; Region: PRK12478 710685002083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685002084 substrate binding site [chemical binding]; other site 710685002085 oxyanion hole (OAH) forming residues; other site 710685002086 trimer interface [polypeptide binding]; other site 710685002087 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 710685002088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685002089 active site 710685002090 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 710685002091 active site 710685002092 endonuclease IV; Provisional; Region: PRK01060 710685002093 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 710685002094 AP (apurinic/apyrimidinic) site pocket; other site 710685002095 DNA interaction; other site 710685002096 Metal-binding active site; metal-binding site 710685002097 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710685002098 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 710685002099 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710685002100 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710685002101 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 710685002102 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 710685002103 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 710685002104 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710685002105 DNA binding site [nucleotide binding] 710685002106 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710685002107 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710685002108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710685002109 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710685002110 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710685002111 RPB10 interaction site [polypeptide binding]; other site 710685002112 RPB1 interaction site [polypeptide binding]; other site 710685002113 RPB11 interaction site [polypeptide binding]; other site 710685002114 RPB3 interaction site [polypeptide binding]; other site 710685002115 RPB12 interaction site [polypeptide binding]; other site 710685002116 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710685002117 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685002118 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685002119 molybdopterin cofactor binding site; other site 710685002120 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710685002121 molybdopterin cofactor binding site; other site 710685002122 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 710685002123 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 710685002124 Walker A/P-loop; other site 710685002125 ATP binding site [chemical binding]; other site 710685002126 Q-loop/lid; other site 710685002127 ABC transporter signature motif; other site 710685002128 Walker B; other site 710685002129 D-loop; other site 710685002130 H-loop/switch region; other site 710685002131 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710685002132 core dimer interface [polypeptide binding]; other site 710685002133 peripheral dimer interface [polypeptide binding]; other site 710685002134 L10 interface [polypeptide binding]; other site 710685002135 L11 interface [polypeptide binding]; other site 710685002136 putative EF-Tu interaction site [polypeptide binding]; other site 710685002137 putative EF-G interaction site [polypeptide binding]; other site 710685002138 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 710685002139 23S rRNA interface [nucleotide binding]; other site 710685002140 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710685002141 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710685002142 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710685002143 nucleotide binding site [chemical binding]; other site 710685002144 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 710685002145 active site 710685002146 catalytic site [active] 710685002147 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 710685002148 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 710685002149 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 710685002150 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710685002151 putative catalytic site [active] 710685002152 putative metal binding site [ion binding]; other site 710685002153 putative phosphate binding site [ion binding]; other site 710685002154 putative catalytic site [active] 710685002155 putative phosphate binding site [ion binding]; other site 710685002156 putative metal binding site [ion binding]; other site 710685002157 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 710685002158 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685002159 DNA binding residues [nucleotide binding] 710685002160 drug binding residues [chemical binding]; other site 710685002161 dimer interface [polypeptide binding]; other site 710685002162 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 710685002163 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685002164 Predicted transcriptional regulator [Transcription]; Region: COG2378 710685002165 WYL domain; Region: WYL; pfam13280 710685002166 DinB superfamily; Region: DinB_2; pfam12867 710685002167 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710685002168 DinB superfamily; Region: DinB_2; pfam12867 710685002169 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685002170 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685002171 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710685002172 metabolite-proton symporter; Region: 2A0106; TIGR00883 710685002173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002174 putative substrate translocation pore; other site 710685002175 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710685002176 ABC1 family; Region: ABC1; pfam03109 710685002177 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710685002178 active site 710685002179 ATP binding site [chemical binding]; other site 710685002180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685002181 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685002182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002183 S-adenosylmethionine binding site [chemical binding]; other site 710685002184 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685002185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002186 S-adenosylmethionine binding site [chemical binding]; other site 710685002187 PE-PPE domain; Region: PE-PPE; pfam08237 710685002188 YCII-related domain; Region: YCII; cl00999 710685002189 YCII-related domain; Region: YCII; cl00999 710685002190 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710685002191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685002192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685002193 DNA binding residues [nucleotide binding] 710685002194 AAA ATPase domain; Region: AAA_16; pfam13191 710685002195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685002196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685002197 DNA binding residues [nucleotide binding] 710685002198 dimerization interface [polypeptide binding]; other site 710685002199 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 710685002200 mRNA/rRNA interface [nucleotide binding]; other site 710685002201 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710685002202 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710685002203 23S rRNA interface [nucleotide binding]; other site 710685002204 L7/L12 interface [polypeptide binding]; other site 710685002205 putative thiostrepton binding site; other site 710685002206 L25 interface [polypeptide binding]; other site 710685002207 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 710685002208 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710685002209 putative homodimer interface [polypeptide binding]; other site 710685002210 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 710685002211 heterodimer interface [polypeptide binding]; other site 710685002212 homodimer interface [polypeptide binding]; other site 710685002213 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 710685002214 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685002215 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 710685002216 active site 710685002217 catalytic site [active] 710685002218 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685002219 active site 710685002220 catalytic site [active] 710685002221 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710685002222 LabA_like proteins; Region: LabA_like; cd06167 710685002223 putative metal binding site [ion binding]; other site 710685002224 Uncharacterized conserved protein [Function unknown]; Region: COG1432 710685002225 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 710685002226 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685002227 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685002228 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 710685002229 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685002230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685002231 substrate binding site [chemical binding]; other site 710685002232 oxyanion hole (OAH) forming residues; other site 710685002233 trimer interface [polypeptide binding]; other site 710685002234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685002237 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 710685002238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685002239 Zn2+ binding site [ion binding]; other site 710685002240 Mg2+ binding site [ion binding]; other site 710685002241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685002242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685002243 DNA binding residues [nucleotide binding] 710685002244 dimerization interface [polypeptide binding]; other site 710685002245 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710685002246 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 710685002247 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 710685002248 oligomer interface [polypeptide binding]; other site 710685002249 metal binding site [ion binding]; metal-binding site 710685002250 metal binding site [ion binding]; metal-binding site 710685002251 putative Cl binding site [ion binding]; other site 710685002252 aspartate ring; other site 710685002253 basic sphincter; other site 710685002254 hydrophobic gate; other site 710685002255 periplasmic entrance; other site 710685002256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710685002257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685002258 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710685002259 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710685002260 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710685002261 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 710685002262 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685002263 Zn2+ binding site [ion binding]; other site 710685002264 Mg2+ binding site [ion binding]; other site 710685002265 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 710685002266 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 710685002267 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 710685002268 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 710685002269 AAA domain; Region: AAA_30; pfam13604 710685002270 Family description; Region: UvrD_C_2; pfam13538 710685002271 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685002272 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710685002273 putative hydrophobic ligand binding site [chemical binding]; other site 710685002274 protein interface [polypeptide binding]; other site 710685002275 gate; other site 710685002276 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710685002277 Sulfatase; Region: Sulfatase; pfam00884 710685002278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685002279 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710685002280 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710685002281 acyl-activating enzyme (AAE) consensus motif; other site 710685002282 active site 710685002283 GAF domain; Region: GAF; pfam01590 710685002284 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685002285 GAF domain; Region: GAF; pfam01590 710685002286 GAF domain; Region: GAF_2; pfam13185 710685002287 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685002288 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685002289 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710685002290 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 710685002291 putative di-iron ligands [ion binding]; other site 710685002292 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685002293 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 710685002294 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710685002295 putative active site [active] 710685002296 putative ligand binding site [chemical binding]; other site 710685002297 putative NAD(P) binding site [chemical binding]; other site 710685002298 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 710685002299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685002300 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 710685002301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 710685002302 tartrate dehydrogenase; Provisional; Region: PRK08194 710685002303 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 710685002304 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 710685002305 active site 710685002306 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 710685002307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685002308 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710685002309 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685002310 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685002311 Putative esterase; Region: Esterase; pfam00756 710685002312 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710685002313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685002314 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710685002315 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685002316 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685002317 RES domain; Region: RES; cl02411 710685002318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685002319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685002320 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 710685002321 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710685002322 active site 710685002323 dimer interface [polypeptide binding]; other site 710685002324 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710685002325 Ligand Binding Site [chemical binding]; other site 710685002326 Molecular Tunnel; other site 710685002327 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 710685002328 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710685002329 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710685002330 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710685002331 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710685002332 PIF1-like helicase; Region: PIF1; pfam05970 710685002333 AAA domain; Region: AAA_30; pfam13604 710685002334 Family description; Region: UvrD_C_2; pfam13538 710685002335 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 710685002336 RibD C-terminal domain; Region: RibD_C; cl17279 710685002337 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710685002338 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685002339 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685002340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002341 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685002342 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710685002343 Walker A/P-loop; other site 710685002344 ATP binding site [chemical binding]; other site 710685002345 Q-loop/lid; other site 710685002346 ABC transporter signature motif; other site 710685002347 Walker B; other site 710685002348 D-loop; other site 710685002349 H-loop/switch region; other site 710685002350 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685002351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685002352 substrate binding pocket [chemical binding]; other site 710685002353 membrane-bound complex binding site; other site 710685002354 hinge residues; other site 710685002355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710685002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685002357 dimer interface [polypeptide binding]; other site 710685002358 conserved gate region; other site 710685002359 putative PBP binding loops; other site 710685002360 ABC-ATPase subunit interface; other site 710685002361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685002362 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685002363 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685002364 YceI-like domain; Region: YceI; smart00867 710685002365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685002366 non-specific DNA binding site [nucleotide binding]; other site 710685002367 salt bridge; other site 710685002368 sequence-specific DNA binding site [nucleotide binding]; other site 710685002369 HipA N-terminal domain; Region: Couple_hipA; pfam13657 710685002370 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 710685002371 HipA-like N-terminal domain; Region: HipA_N; pfam07805 710685002372 HipA-like C-terminal domain; Region: HipA_C; pfam07804 710685002373 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 710685002374 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 710685002375 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 710685002376 G1 box; other site 710685002377 putative GEF interaction site [polypeptide binding]; other site 710685002378 GTP/Mg2+ binding site [chemical binding]; other site 710685002379 Switch I region; other site 710685002380 G2 box; other site 710685002381 G3 box; other site 710685002382 Switch II region; other site 710685002383 G4 box; other site 710685002384 G5 box; other site 710685002385 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710685002386 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 710685002387 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710685002388 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710685002389 short chain dehydrogenase; Provisional; Region: PRK07109 710685002390 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 710685002391 putative NAD(P) binding site [chemical binding]; other site 710685002392 active site 710685002393 thiamine pyrophosphate protein; Provisional; Region: PRK08273 710685002394 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 710685002395 PYR/PP interface [polypeptide binding]; other site 710685002396 dimer interface [polypeptide binding]; other site 710685002397 tetramer interface [polypeptide binding]; other site 710685002398 TPP binding site [chemical binding]; other site 710685002399 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685002400 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 710685002401 TPP-binding site [chemical binding]; other site 710685002402 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 710685002403 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710685002404 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685002405 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 710685002406 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 710685002407 metal binding site [ion binding]; metal-binding site 710685002408 substrate binding pocket [chemical binding]; other site 710685002409 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710685002410 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710685002411 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 710685002412 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 710685002413 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685002414 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 710685002415 oligomeric interface; other site 710685002416 putative active site [active] 710685002417 homodimer interface [polypeptide binding]; other site 710685002418 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710685002419 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 710685002420 nudix motif; other site 710685002421 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 710685002422 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 710685002423 active site 710685002424 catalytic residues [active] 710685002425 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 710685002426 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 710685002427 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 710685002428 Nuclease-related domain; Region: NERD; pfam08378 710685002429 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710685002430 Walker A motif; other site 710685002431 ATP binding site [chemical binding]; other site 710685002432 ATPase MipZ; Region: MipZ; pfam09140 710685002433 Family description; Region: UvrD_C_2; pfam13538 710685002434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685002435 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685002436 active site 710685002437 catalytic tetrad [active] 710685002438 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685002439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685002440 AAA domain; Region: AAA_23; pfam13476 710685002441 Walker A/P-loop; other site 710685002442 ATP binding site [chemical binding]; other site 710685002443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 710685002444 ABC transporter signature motif; other site 710685002445 Walker B; other site 710685002446 D-loop; other site 710685002447 H-loop/switch region; other site 710685002448 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 710685002449 metal binding site [ion binding]; metal-binding site 710685002450 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710685002451 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685002452 active site 710685002453 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 710685002454 PLD-like domain; Region: PLDc_2; pfam13091 710685002455 putative homodimer interface [polypeptide binding]; other site 710685002456 putative active site [active] 710685002457 catalytic site [active] 710685002458 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710685002459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685002460 nucleotide binding region [chemical binding]; other site 710685002461 ATP-binding site [chemical binding]; other site 710685002462 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 710685002463 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710685002464 ATP-binding site [chemical binding]; other site 710685002465 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 710685002466 PLD-like domain; Region: PLDc_2; pfam13091 710685002467 putative homodimer interface [polypeptide binding]; other site 710685002468 putative active site [active] 710685002469 catalytic site [active] 710685002470 AAA domain; Region: AAA_11; pfam13086 710685002471 Part of AAA domain; Region: AAA_19; pfam13245 710685002472 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710685002473 AAA domain; Region: AAA_12; pfam13087 710685002474 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685002475 putative active site [active] 710685002476 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 710685002477 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 710685002478 DNA methylase; Region: N6_N4_Mtase; cl17433 710685002479 DNA methylase; Region: N6_N4_Mtase; pfam01555 710685002480 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 710685002481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685002482 Walker A/P-loop; other site 710685002483 ATP binding site [chemical binding]; other site 710685002484 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710685002485 Part of AAA domain; Region: AAA_19; pfam13245 710685002486 Family description; Region: UvrD_C_2; pfam13538 710685002487 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710685002488 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 710685002489 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 710685002490 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685002491 anti sigma factor interaction site; other site 710685002492 regulatory phosphorylation site [posttranslational modification]; other site 710685002493 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685002494 GAF domain; Region: GAF; pfam01590 710685002495 GAF domain; Region: GAF_3; pfam13492 710685002496 GAF domain; Region: GAF_3; pfam13492 710685002497 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710685002498 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685002499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685002500 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685002501 ATP binding site [chemical binding]; other site 710685002502 Mg2+ binding site [ion binding]; other site 710685002503 G-X-G motif; other site 710685002504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 710685002505 P-loop containing region of AAA domain; Region: AAA_29; cl17516 710685002506 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 710685002507 Thioredoxin; Region: Thioredoxin_4; cl17273 710685002508 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710685002509 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 710685002510 homodimer interface [polypeptide binding]; other site 710685002511 putative active site [active] 710685002512 ERCC4 domain; Region: ERCC4; smart00891 710685002513 Lsr2; Region: Lsr2; pfam11774 710685002514 SEC-C motif; Region: SEC-C; pfam02810 710685002515 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 710685002516 Cupin superfamily protein; Region: Cupin_4; pfam08007 710685002517 Cupin-like domain; Region: Cupin_8; pfam13621 710685002518 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 710685002519 putative dimer interface [polypeptide binding]; other site 710685002520 putative [2Fe-2S] cluster binding site [ion binding]; other site 710685002521 Hemerythrin-like domain; Region: Hr-like; cd12108 710685002522 Fe binding site [ion binding]; other site 710685002523 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685002524 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 710685002525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710685002526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685002527 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710685002528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002530 putative substrate translocation pore; other site 710685002531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685002532 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710685002533 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685002534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685002535 Coenzyme A binding pocket [chemical binding]; other site 710685002536 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710685002537 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685002538 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710685002539 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 710685002540 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710685002541 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710685002542 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685002543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710685002544 hypothetical protein; Provisional; Region: PRK07588 710685002545 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685002546 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685002547 anti sigma factor interaction site; other site 710685002548 regulatory phosphorylation site [posttranslational modification]; other site 710685002549 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685002550 Cytochrome P450; Region: p450; cl12078 710685002551 acyl-CoA synthetase; Provisional; Region: PRK13388 710685002552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685002553 acyl-activating enzyme (AAE) consensus motif; other site 710685002554 AMP binding site [chemical binding]; other site 710685002555 active site 710685002556 CoA binding site [chemical binding]; other site 710685002557 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685002558 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685002559 thiolase; Provisional; Region: PRK06158 710685002560 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685002561 active site 710685002562 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685002563 active site 2 [active] 710685002564 active site 1 [active] 710685002565 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685002566 active site 710685002567 catalytic site [active] 710685002568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685002569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685002570 active site 710685002571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685002572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685002573 active site 710685002574 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710685002575 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685002576 Cytochrome P450; Region: p450; cl12078 710685002577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002578 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710685002579 DNA-binding interface [nucleotide binding]; DNA binding site 710685002580 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685002581 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685002582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002584 WHG domain; Region: WHG; pfam13305 710685002585 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685002586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685002587 active site 710685002588 ATP binding site [chemical binding]; other site 710685002589 substrate binding site [chemical binding]; other site 710685002590 activation loop (A-loop); other site 710685002591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685002592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685002593 ligand binding site [chemical binding]; other site 710685002594 flexible hinge region; other site 710685002595 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685002596 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685002597 active site 710685002598 ATP binding site [chemical binding]; other site 710685002599 substrate binding site [chemical binding]; other site 710685002600 activation loop (A-loop); other site 710685002601 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685002602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685002603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002604 S-adenosylmethionine binding site [chemical binding]; other site 710685002605 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685002606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002607 S-adenosylmethionine binding site [chemical binding]; other site 710685002608 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710685002609 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710685002610 dimer interface [polypeptide binding]; other site 710685002611 active site 710685002612 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710685002613 DNA-binding site [nucleotide binding]; DNA binding site 710685002614 RNA-binding motif; other site 710685002615 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710685002616 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 710685002617 amidase catalytic site [active] 710685002618 Zn binding residues [ion binding]; other site 710685002619 substrate binding site [chemical binding]; other site 710685002620 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710685002621 Predicted metalloprotease [General function prediction only]; Region: COG2321 710685002622 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710685002623 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685002624 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685002625 active site 710685002626 ATP binding site [chemical binding]; other site 710685002627 substrate binding site [chemical binding]; other site 710685002628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685002629 substrate binding site [chemical binding]; other site 710685002630 activation loop (A-loop); other site 710685002631 activation loop (A-loop); other site 710685002632 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710685002633 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685002634 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685002635 active site 710685002636 ATP binding site [chemical binding]; other site 710685002637 substrate binding site [chemical binding]; other site 710685002638 activation loop (A-loop); other site 710685002639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685002640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685002641 substrate binding pocket [chemical binding]; other site 710685002642 membrane-bound complex binding site; other site 710685002643 hinge residues; other site 710685002644 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685002645 Cytochrome P450; Region: p450; cl12078 710685002646 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 710685002647 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710685002648 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 710685002649 acetyl-CoA decarbonylase/synthase complex subunit alpha; Validated; Region: PRK00941 710685002650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685002651 NAD(P) binding site [chemical binding]; other site 710685002652 active site 710685002653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685002654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685002655 DNA binding residues [nucleotide binding] 710685002656 dimerization interface [polypeptide binding]; other site 710685002657 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710685002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002660 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710685002661 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685002662 FAD binding domain; Region: FAD_binding_4; pfam01565 710685002663 Berberine and berberine like; Region: BBE; pfam08031 710685002664 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710685002665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 710685002666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685002667 putative metal binding site [ion binding]; other site 710685002668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685002669 dimerization interface [polypeptide binding]; other site 710685002670 putative DNA binding site [nucleotide binding]; other site 710685002671 putative Zn2+ binding site [ion binding]; other site 710685002672 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710685002673 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 710685002674 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 710685002675 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685002676 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685002677 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685002679 NAD(P) binding site [chemical binding]; other site 710685002680 active site 710685002681 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710685002682 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685002683 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685002684 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685002685 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 710685002686 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710685002687 dimer interface [polypeptide binding]; other site 710685002688 acyl-activating enzyme (AAE) consensus motif; other site 710685002689 putative active site [active] 710685002690 AMP binding site [chemical binding]; other site 710685002691 putative CoA binding site [chemical binding]; other site 710685002692 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710685002693 Sulfatase; Region: Sulfatase; pfam00884 710685002694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 710685002695 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 710685002696 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685002697 Transglutaminase/protease-like homologues; Region: TGc; smart00460 710685002698 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 710685002699 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710685002700 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710685002701 heat shock protein HtpX; Provisional; Region: PRK03072 710685002702 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710685002703 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710685002704 substrate binding pocket [chemical binding]; other site 710685002705 chain length determination region; other site 710685002706 substrate-Mg2+ binding site; other site 710685002707 catalytic residues [active] 710685002708 aspartate-rich region 1; other site 710685002709 active site lid residues [active] 710685002710 aspartate-rich region 2; other site 710685002711 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710685002712 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685002713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685002714 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685002715 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 710685002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002717 S-adenosylmethionine binding site [chemical binding]; other site 710685002718 short chain dehydrogenase; Provisional; Region: PRK08263 710685002719 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710685002720 NADP binding site [chemical binding]; other site 710685002721 active site 710685002722 steroid binding site; other site 710685002723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685002724 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710685002725 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710685002726 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 710685002727 catalytic residues [active] 710685002728 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 710685002729 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 710685002730 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 710685002731 dimer interface [polypeptide binding]; other site 710685002732 tetramer interface [polypeptide binding]; other site 710685002733 PYR/PP interface [polypeptide binding]; other site 710685002734 TPP binding site [chemical binding]; other site 710685002735 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 710685002736 TPP-binding site; other site 710685002737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685002738 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685002739 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 710685002740 Homeodomain-like domain; Region: HTH_32; pfam13565 710685002741 putative transposase OrfB; Reviewed; Region: PHA02517 710685002742 Integrase core domain; Region: rve; pfam00665 710685002743 Integrase core domain; Region: rve_3; pfam13683 710685002744 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710685002745 DJ-1 family protein; Region: not_thiJ; TIGR01383 710685002746 conserved cys residue [active] 710685002747 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710685002748 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710685002749 conserved cys residue [active] 710685002750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685002751 O-succinylbenzoate synthase; Provisional; Region: PRK02901 710685002752 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 710685002753 active site 710685002754 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710685002755 TspO/MBR family; Region: TspO_MBR; pfam03073 710685002756 SOUL heme-binding protein; Region: SOUL; pfam04832 710685002757 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685002758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685002759 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685002760 acyl-activating enzyme (AAE) consensus motif; other site 710685002761 acyl-activating enzyme (AAE) consensus motif; other site 710685002762 putative AMP binding site [chemical binding]; other site 710685002763 putative active site [active] 710685002764 putative CoA binding site [chemical binding]; other site 710685002765 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710685002766 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710685002767 active site 710685002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 710685002769 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 710685002770 acyl-CoA synthetase; Validated; Region: PRK06188 710685002771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685002772 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685002773 acyl-activating enzyme (AAE) consensus motif; other site 710685002774 acyl-activating enzyme (AAE) consensus motif; other site 710685002775 putative AMP binding site [chemical binding]; other site 710685002776 putative active site [active] 710685002777 putative CoA binding site [chemical binding]; other site 710685002778 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 710685002779 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 710685002780 active site 710685002781 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710685002782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685002783 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710685002784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002785 S-adenosylmethionine binding site [chemical binding]; other site 710685002786 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 710685002787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685002788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710685002789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685002790 active site 710685002791 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 710685002792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685002793 motif II; other site 710685002794 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685002795 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685002796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685002797 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710685002798 substrate binding site [chemical binding]; other site 710685002799 oxyanion hole (OAH) forming residues; other site 710685002800 trimer interface [polypeptide binding]; other site 710685002801 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710685002802 short chain dehydrogenase; Provisional; Region: PRK05866 710685002803 classical (c) SDRs; Region: SDR_c; cd05233 710685002804 NAD(P) binding site [chemical binding]; other site 710685002805 active site 710685002806 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685002807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685002808 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685002809 acyl-activating enzyme (AAE) consensus motif; other site 710685002810 acyl-activating enzyme (AAE) consensus motif; other site 710685002811 putative AMP binding site [chemical binding]; other site 710685002812 putative active site [active] 710685002813 putative CoA binding site [chemical binding]; other site 710685002814 CoA binding site [chemical binding]; other site 710685002815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685002816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685002817 active site 710685002818 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710685002819 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 710685002820 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710685002821 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 710685002822 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685002823 active site 710685002824 CoA binding site [chemical binding]; other site 710685002825 AMP binding site [chemical binding]; other site 710685002826 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685002827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685002828 active site 710685002829 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 710685002830 homodimer interface [polypeptide binding]; other site 710685002831 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 710685002832 active site pocket [active] 710685002833 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 710685002834 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710685002835 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 710685002836 Moco binding site; other site 710685002837 metal coordination site [ion binding]; other site 710685002838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685002839 S-adenosylmethionine binding site [chemical binding]; other site 710685002840 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 710685002841 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710685002842 Ligand binding site; other site 710685002843 Putative Catalytic site; other site 710685002844 DXD motif; other site 710685002845 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685002847 active site 710685002848 phosphorylation site [posttranslational modification] 710685002849 intermolecular recognition site; other site 710685002850 dimerization interface [polypeptide binding]; other site 710685002851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685002852 DNA binding site [nucleotide binding] 710685002853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685002854 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685002855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685002856 dimer interface [polypeptide binding]; other site 710685002857 phosphorylation site [posttranslational modification] 710685002858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685002859 ATP binding site [chemical binding]; other site 710685002860 Mg2+ binding site [ion binding]; other site 710685002861 G-X-G motif; other site 710685002862 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685002863 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 710685002864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685002865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685002866 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710685002867 Serine hydrolase (FSH1); Region: FSH1; pfam03959 710685002868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685002869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685002870 NAD(P) binding site [chemical binding]; other site 710685002871 active site 710685002872 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 710685002873 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 710685002874 UbiA prenyltransferase family; Region: UbiA; pfam01040 710685002875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002877 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685002878 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710685002879 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685002880 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 710685002881 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710685002882 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710685002883 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 710685002884 ResB-like family; Region: ResB; pfam05140 710685002885 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710685002886 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710685002887 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710685002888 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685002889 catalytic residues [active] 710685002890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685002891 catalytic core [active] 710685002892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685002893 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 710685002894 inhibitor-cofactor binding pocket; inhibition site 710685002895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685002896 catalytic residue [active] 710685002897 DivIVA domain; Region: DivI1A_domain; TIGR03544 710685002898 DivIVA domain; Region: DivI1A_domain; TIGR03544 710685002899 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685002900 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710685002901 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685002902 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685002903 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685002904 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685002905 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685002906 Cytochrome P450; Region: p450; pfam00067 710685002907 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685002908 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710685002909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002911 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710685002912 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685002913 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685002914 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685002915 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 710685002916 dimer interface [polypeptide binding]; other site 710685002917 active site 710685002918 Schiff base residues; other site 710685002919 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 710685002920 active site 710685002921 homodimer interface [polypeptide binding]; other site 710685002922 SAM binding site [chemical binding]; other site 710685002923 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 710685002924 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710685002925 active site 710685002926 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 710685002927 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 710685002928 domain interfaces; other site 710685002929 active site 710685002930 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 710685002931 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 710685002932 tRNA; other site 710685002933 putative tRNA binding site [nucleotide binding]; other site 710685002934 putative NADP binding site [chemical binding]; other site 710685002935 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 710685002936 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 710685002937 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710685002938 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710685002939 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685002940 active site 710685002941 catalytic site [active] 710685002942 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685002943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685002944 putative acyl-acceptor binding pocket; other site 710685002945 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685002946 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 710685002947 putative NAD(P) binding site [chemical binding]; other site 710685002948 active site 710685002949 putative substrate binding site [chemical binding]; other site 710685002950 DNA binding domain, excisionase family; Region: excise; TIGR01764 710685002951 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 710685002952 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710685002953 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685002954 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 710685002955 active site 2 [active] 710685002956 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710685002957 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710685002958 DNA interaction; other site 710685002959 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710685002960 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710685002961 YCII-related domain; Region: YCII; pfam03795 710685002962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685002963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685002964 active site 710685002965 phosphorylation site [posttranslational modification] 710685002966 intermolecular recognition site; other site 710685002967 dimerization interface [polypeptide binding]; other site 710685002968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685002969 DNA binding site [nucleotide binding] 710685002970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685002971 dimer interface [polypeptide binding]; other site 710685002972 phosphorylation site [posttranslational modification] 710685002973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685002974 ATP binding site [chemical binding]; other site 710685002975 Mg2+ binding site [ion binding]; other site 710685002976 G-X-G motif; other site 710685002977 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685002978 catalytic core [active] 710685002979 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685002980 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 710685002981 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 710685002982 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 710685002983 putative ADP-binding pocket [chemical binding]; other site 710685002984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710685002985 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710685002986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685002987 NAD(P) binding site [chemical binding]; other site 710685002988 active site 710685002989 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710685002990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685002991 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710685002992 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685002993 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 710685002994 FAD binding domain; Region: FAD_binding_4; pfam01565 710685002995 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 710685002996 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710685002997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685002998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685002999 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 710685003000 Subunit I/III interface [polypeptide binding]; other site 710685003001 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 710685003002 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685003003 Cytochrome P450; Region: p450; cl12078 710685003004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003006 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685003007 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685003008 Cytochrome P450; Region: p450; cl12078 710685003009 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685003010 classical (c) SDRs; Region: SDR_c; cd05233 710685003011 NAD(P) binding site [chemical binding]; other site 710685003012 active site 710685003013 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685003014 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685003015 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685003016 NAD binding site [chemical binding]; other site 710685003017 catalytic residues [active] 710685003018 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685003019 mce related protein; Region: MCE; pfam02470 710685003020 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685003021 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685003022 mce related protein; Region: MCE; pfam02470 710685003023 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685003024 mce related protein; Region: MCE; pfam02470 710685003025 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685003026 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685003027 mce related protein; Region: MCE; pfam02470 710685003028 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685003029 mce related protein; Region: MCE; pfam02470 710685003030 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685003031 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685003032 mce related protein; Region: MCE; pfam02470 710685003033 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685003034 Cytochrome P450; Region: p450; cl12078 710685003035 thiolase; Provisional; Region: PRK06158 710685003036 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685003037 active site 710685003038 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685003039 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685003040 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685003041 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685003042 Phosphotransferase enzyme family; Region: APH; pfam01636 710685003043 Ecdysteroid kinase; Region: EcKinase; cl17738 710685003044 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685003045 classical (c) SDRs; Region: SDR_c; cd05233 710685003046 NAD(P) binding site [chemical binding]; other site 710685003047 active site 710685003048 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 710685003049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003050 acyl-activating enzyme (AAE) consensus motif; other site 710685003051 AMP binding site [chemical binding]; other site 710685003052 active site 710685003053 CoA binding site [chemical binding]; other site 710685003054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685003055 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 710685003056 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 710685003057 Na binding site [ion binding]; other site 710685003058 putative glycosylation site [posttranslational modification]; other site 710685003059 putative glycosylation site [posttranslational modification]; other site 710685003060 ykkC-yxkD leader 710685003061 agmatinase; Region: agmatinase; TIGR01230 710685003062 Agmatinase-like family; Region: Agmatinase-like; cd09990 710685003063 active site 710685003064 oligomer interface [polypeptide binding]; other site 710685003065 Mn binding site [ion binding]; other site 710685003066 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710685003067 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 710685003068 putative active site [active] 710685003069 catalytic triad [active] 710685003070 putative dimer interface [polypeptide binding]; other site 710685003071 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710685003072 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710685003073 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 710685003074 active site 710685003075 catalytic triad [active] 710685003076 calcium binding site [ion binding]; other site 710685003077 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 710685003078 intersubunit interface [polypeptide binding]; other site 710685003079 active site 710685003080 catalytic residue [active] 710685003081 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 710685003082 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 710685003083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685003084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685003085 non-specific DNA binding site [nucleotide binding]; other site 710685003086 salt bridge; other site 710685003087 sequence-specific DNA binding site [nucleotide binding]; other site 710685003088 Predicted membrane protein [Function unknown]; Region: COG2733 710685003089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003091 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 710685003092 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685003093 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 710685003094 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710685003095 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710685003096 isocitrate lyase; Provisional; Region: PRK15063 710685003097 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710685003098 tetramer interface [polypeptide binding]; other site 710685003099 active site 710685003100 Mg2+/Mn2+ binding site [ion binding]; other site 710685003101 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685003102 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 710685003103 active site 2 [active] 710685003104 active site 1 [active] 710685003105 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685003106 active site 2 [active] 710685003107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685003109 non-specific DNA binding site [nucleotide binding]; other site 710685003110 salt bridge; other site 710685003111 sequence-specific DNA binding site [nucleotide binding]; other site 710685003112 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 710685003113 Domain of unknown function (DUF955); Region: DUF955; pfam06114 710685003114 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 710685003115 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685003116 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685003117 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 710685003118 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 710685003119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685003120 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685003121 Protein of unknown function (DUF779); Region: DUF779; pfam05610 710685003122 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710685003123 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685003124 NAD(P) binding site [chemical binding]; other site 710685003125 catalytic residues [active] 710685003126 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 710685003127 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685003128 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710685003129 Imelysin; Region: Peptidase_M75; pfam09375 710685003130 enoyl-CoA hydratase; Provisional; Region: PRK12478 710685003131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685003132 substrate binding site [chemical binding]; other site 710685003133 oxyanion hole (OAH) forming residues; other site 710685003134 trimer interface [polypeptide binding]; other site 710685003135 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 710685003136 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 710685003137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685003138 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 710685003139 NAD(P) binding site [chemical binding]; other site 710685003140 catalytic residues [active] 710685003141 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710685003142 active site 710685003143 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710685003144 DinB superfamily; Region: DinB_2; pfam12867 710685003145 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 710685003146 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710685003147 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 710685003148 active site 710685003149 putative substrate binding pocket [chemical binding]; other site 710685003150 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685003151 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685003152 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685003153 classical (c) SDRs; Region: SDR_c; cd05233 710685003154 NAD(P) binding site [chemical binding]; other site 710685003155 active site 710685003156 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 710685003157 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 710685003158 putative NAD(P) binding site [chemical binding]; other site 710685003159 dimer interface [polypeptide binding]; other site 710685003160 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685003161 putative active site [active] 710685003162 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710685003163 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710685003164 ring oligomerisation interface [polypeptide binding]; other site 710685003165 ATP/Mg binding site [chemical binding]; other site 710685003166 stacking interactions; other site 710685003167 hinge regions; other site 710685003168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003170 short chain dehydrogenase; Provisional; Region: PRK06197 710685003171 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710685003172 putative NAD(P) binding site [chemical binding]; other site 710685003173 active site 710685003174 Cupin domain; Region: Cupin_2; pfam07883 710685003175 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 710685003176 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710685003177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685003178 ABC transporter signature motif; other site 710685003179 Walker B; other site 710685003180 D-loop; other site 710685003181 H-loop/switch region; other site 710685003182 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710685003183 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 710685003184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685003185 ATP binding site [chemical binding]; other site 710685003186 putative Mg++ binding site [ion binding]; other site 710685003187 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 710685003188 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710685003189 DNA binding site [nucleotide binding] 710685003190 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685003191 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685003192 phosphopeptide binding site; other site 710685003193 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 710685003194 putative hydrophobic ligand binding site [chemical binding]; other site 710685003195 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710685003196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685003197 active site 710685003198 motif I; other site 710685003199 motif II; other site 710685003200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685003201 Predicted membrane protein [Function unknown]; Region: COG3428 710685003202 Bacterial PH domain; Region: DUF304; pfam03703 710685003203 Uncharacterized conserved protein [Function unknown]; Region: COG3402 710685003204 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685003205 short chain dehydrogenase; Provisional; Region: PRK06197 710685003206 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710685003207 putative NAD(P) binding site [chemical binding]; other site 710685003208 active site 710685003209 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710685003210 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710685003211 dimer interface [polypeptide binding]; other site 710685003212 putative functional site; other site 710685003213 putative MPT binding site; other site 710685003214 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 710685003215 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 710685003216 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 710685003217 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 710685003218 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 710685003219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685003220 Walker A motif; other site 710685003221 ATP binding site [chemical binding]; other site 710685003222 Walker B motif; other site 710685003223 arginine finger; other site 710685003224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685003225 Walker A motif; other site 710685003226 ATP binding site [chemical binding]; other site 710685003227 Walker B motif; other site 710685003228 arginine finger; other site 710685003229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685003230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685003231 S-adenosylmethionine binding site [chemical binding]; other site 710685003232 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710685003233 2TM domain; Region: 2TM; pfam13239 710685003234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685003235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685003236 active site 710685003237 phosphorylation site [posttranslational modification] 710685003238 intermolecular recognition site; other site 710685003239 dimerization interface [polypeptide binding]; other site 710685003240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685003241 DNA binding residues [nucleotide binding] 710685003242 dimerization interface [polypeptide binding]; other site 710685003243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710685003244 Histidine kinase; Region: HisKA_3; pfam07730 710685003245 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710685003246 ATP binding site [chemical binding]; other site 710685003247 Mg2+ binding site [ion binding]; other site 710685003248 G-X-G motif; other site 710685003249 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710685003250 FOG: CBS domain [General function prediction only]; Region: COG0517 710685003251 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710685003252 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 710685003253 transmembrane helices; other site 710685003254 hypothetical protein; Provisional; Region: PRK08244 710685003255 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685003256 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 710685003257 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710685003258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710685003259 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 710685003260 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 710685003261 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 710685003262 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 710685003263 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710685003264 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 710685003265 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 710685003266 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 710685003267 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685003268 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685003269 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 710685003270 carboxylate-amine ligase; Provisional; Region: PRK13517 710685003271 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710685003272 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 710685003273 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 710685003274 E-class dimer interface [polypeptide binding]; other site 710685003275 P-class dimer interface [polypeptide binding]; other site 710685003276 active site 710685003277 Cu2+ binding site [ion binding]; other site 710685003278 Zn2+ binding site [ion binding]; other site 710685003279 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710685003280 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 710685003281 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710685003282 active site 710685003283 catalytic residues [active] 710685003284 metal binding site [ion binding]; metal-binding site 710685003285 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710685003286 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685003287 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685003288 active site 710685003289 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 710685003290 putative catalytic site [active] 710685003291 putative phosphate binding site [ion binding]; other site 710685003292 active site 710685003293 metal binding site A [ion binding]; metal-binding site 710685003294 DNA binding site [nucleotide binding] 710685003295 putative AP binding site [nucleotide binding]; other site 710685003296 putative metal binding site B [ion binding]; other site 710685003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685003298 putative substrate translocation pore; other site 710685003299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685003300 putative substrate translocation pore; other site 710685003301 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 710685003302 ThiC-associated domain; Region: ThiC-associated; pfam13667 710685003303 ThiC family; Region: ThiC; pfam01964 710685003304 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 710685003305 dimer interface [polypeptide binding]; other site 710685003306 substrate binding site [chemical binding]; other site 710685003307 ATP binding site [chemical binding]; other site 710685003308 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 710685003309 Septum formation; Region: Septum_form; pfam13845 710685003310 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685003311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685003312 Predicted membrane protein [Function unknown]; Region: COG4270 710685003313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003317 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685003318 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 710685003319 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710685003320 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710685003321 PA/protease or protease-like domain interface [polypeptide binding]; other site 710685003322 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710685003323 Peptidase family M28; Region: Peptidase_M28; pfam04389 710685003324 active site 710685003325 metal binding site [ion binding]; metal-binding site 710685003326 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 710685003327 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710685003328 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710685003329 PA/protease or protease-like domain interface [polypeptide binding]; other site 710685003330 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710685003331 active site 710685003332 metal binding site [ion binding]; metal-binding site 710685003333 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 710685003334 active site 710685003335 catalytic triad [active] 710685003336 oxyanion hole [active] 710685003337 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 710685003338 ThiS interaction site; other site 710685003339 putative active site [active] 710685003340 tetramer interface [polypeptide binding]; other site 710685003341 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 710685003342 thiS-thiF/thiG interaction site; other site 710685003343 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710685003344 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710685003345 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 710685003346 thiamine phosphate binding site [chemical binding]; other site 710685003347 active site 710685003348 pyrophosphate binding site [ion binding]; other site 710685003349 NUDIX domain; Region: NUDIX; pfam00293 710685003350 nudix motif; other site 710685003351 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 710685003352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685003353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685003354 substrate binding pocket [chemical binding]; other site 710685003355 membrane-bound complex binding site; other site 710685003356 hinge residues; other site 710685003357 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685003358 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685003359 active site 710685003360 ATP binding site [chemical binding]; other site 710685003361 substrate binding site [chemical binding]; other site 710685003362 activation loop (A-loop); other site 710685003363 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685003364 anti sigma factor interaction site; other site 710685003365 regulatory phosphorylation site [posttranslational modification]; other site 710685003366 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 710685003367 propionate/acetate kinase; Provisional; Region: PRK12379 710685003368 phosphate acetyltransferase; Reviewed; Region: PRK05632 710685003369 DRTGG domain; Region: DRTGG; pfam07085 710685003370 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 710685003371 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710685003372 putative catalytic site [active] 710685003373 putative metal binding site [ion binding]; other site 710685003374 putative phosphate binding site [ion binding]; other site 710685003375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003376 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685003377 NAD(P) binding site [chemical binding]; other site 710685003378 active site 710685003379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685003380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710685003381 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 710685003382 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 710685003383 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710685003384 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 710685003385 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710685003386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710685003387 active site 710685003388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710685003389 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 710685003390 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 710685003391 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 710685003392 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685003393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685003394 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710685003395 active site 710685003396 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710685003397 non-prolyl cis peptide bond; other site 710685003398 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710685003399 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 710685003400 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685003401 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685003402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685003403 Coenzyme A binding pocket [chemical binding]; other site 710685003404 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710685003405 classical (c) SDRs; Region: SDR_c; cd05233 710685003406 NAD(P) binding site [chemical binding]; other site 710685003407 active site 710685003408 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685003409 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685003410 active site 710685003411 short chain dehydrogenase; Provisional; Region: PRK07825 710685003412 classical (c) SDRs; Region: SDR_c; cd05233 710685003413 NAD(P) binding site [chemical binding]; other site 710685003414 active site 710685003415 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 710685003416 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710685003417 homodimer interface [polypeptide binding]; other site 710685003418 substrate-cofactor binding pocket; other site 710685003419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685003420 catalytic residue [active] 710685003421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710685003422 active site residue [active] 710685003423 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 710685003424 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685003425 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710685003426 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 710685003427 MarR family; Region: MarR_2; pfam12802 710685003428 MMPL family; Region: MMPL; pfam03176 710685003429 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685003430 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685003431 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685003432 Cytochrome P450; Region: p450; cl12078 710685003433 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685003434 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685003435 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685003436 CoenzymeA binding site [chemical binding]; other site 710685003437 subunit interaction site [polypeptide binding]; other site 710685003438 PHB binding site; other site 710685003439 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 710685003440 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 710685003441 GDP-binding site [chemical binding]; other site 710685003442 ACT binding site; other site 710685003443 IMP binding site; other site 710685003444 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 710685003445 Peptidase family M50; Region: Peptidase_M50; pfam02163 710685003446 active site 710685003447 putative substrate binding region [chemical binding]; other site 710685003448 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 710685003449 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 710685003450 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 710685003451 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 710685003452 active site 710685003453 intersubunit interface [polypeptide binding]; other site 710685003454 zinc binding site [ion binding]; other site 710685003455 Na+ binding site [ion binding]; other site 710685003456 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710685003457 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710685003458 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 710685003459 Thioredoxin; Region: Thioredoxin_4; pfam13462 710685003460 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710685003461 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 710685003462 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710685003463 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710685003464 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685003465 classical (c) SDRs; Region: SDR_c; cd05233 710685003466 NAD(P) binding site [chemical binding]; other site 710685003467 active site 710685003468 acyl-CoA synthetase; Validated; Region: PRK07788 710685003469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003471 acyl-activating enzyme (AAE) consensus motif; other site 710685003472 AMP binding site [chemical binding]; other site 710685003473 active site 710685003474 CoA binding site [chemical binding]; other site 710685003475 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 710685003476 Clp amino terminal domain; Region: Clp_N; pfam02861 710685003477 Clp amino terminal domain; Region: Clp_N; pfam02861 710685003478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685003479 Walker A motif; other site 710685003480 ATP binding site [chemical binding]; other site 710685003481 Walker B motif; other site 710685003482 arginine finger; other site 710685003483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685003484 Walker A motif; other site 710685003485 ATP binding site [chemical binding]; other site 710685003486 Walker B motif; other site 710685003487 arginine finger; other site 710685003488 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710685003489 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710685003490 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710685003491 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710685003492 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710685003493 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710685003494 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710685003495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 710685003496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 710685003497 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710685003498 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710685003499 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710685003500 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685003501 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710685003502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003504 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 710685003505 heme-binding site [chemical binding]; other site 710685003506 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 710685003507 FMN reductase; Validated; Region: fre; PRK08051 710685003508 FAD binding pocket [chemical binding]; other site 710685003509 FAD binding motif [chemical binding]; other site 710685003510 phosphate binding motif [ion binding]; other site 710685003511 beta-alpha-beta structure motif; other site 710685003512 NAD binding pocket [chemical binding]; other site 710685003513 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 710685003514 active site 710685003515 catalytic residues [active] 710685003516 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 710685003517 DNA binding residues [nucleotide binding] 710685003518 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685003519 putative dimer interface [polypeptide binding]; other site 710685003520 chaperone protein DnaJ; Provisional; Region: PRK14279 710685003521 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710685003522 HSP70 interaction site [polypeptide binding]; other site 710685003523 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710685003524 Zn binding sites [ion binding]; other site 710685003525 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710685003526 dimer interface [polypeptide binding]; other site 710685003527 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 710685003528 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710685003529 dimer interface [polypeptide binding]; other site 710685003530 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710685003531 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710685003532 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 710685003533 nucleotide binding site [chemical binding]; other site 710685003534 NEF interaction site [polypeptide binding]; other site 710685003535 SBD interface [polypeptide binding]; other site 710685003536 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 710685003537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685003538 Hemerythrin-like domain; Region: Hr-like; cd12108 710685003539 Fe binding site [ion binding]; other site 710685003540 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685003541 TIGR03085 family protein; Region: TIGR03085 710685003542 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685003543 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685003544 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710685003545 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710685003546 G1 box; other site 710685003547 GTP/Mg2+ binding site [chemical binding]; other site 710685003548 G2 box; other site 710685003549 Switch I region; other site 710685003550 G3 box; other site 710685003551 Switch II region; other site 710685003552 G4 box; other site 710685003553 G5 box; other site 710685003554 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710685003555 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710685003556 G1 box; other site 710685003557 GTP/Mg2+ binding site [chemical binding]; other site 710685003558 G2 box; other site 710685003559 Switch I region; other site 710685003560 G3 box; other site 710685003561 Switch II region; other site 710685003562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685003563 nucleotide binding site [chemical binding]; other site 710685003564 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685003565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685003566 DNA binding residues [nucleotide binding] 710685003567 dimerization interface [polypeptide binding]; other site 710685003568 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 710685003569 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710685003570 4Fe-4S binding domain; Region: Fer4; cl02805 710685003571 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710685003572 4Fe-4S binding domain; Region: Fer4; pfam00037 710685003573 Cysteine-rich domain; Region: CCG; pfam02754 710685003574 Cysteine-rich domain; Region: CCG; pfam02754 710685003575 aminotransferase AlaT; Validated; Region: PRK09265 710685003576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685003577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685003578 homodimer interface [polypeptide binding]; other site 710685003579 catalytic residue [active] 710685003580 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710685003581 YibE/F-like protein; Region: YibE_F; pfam07907 710685003582 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 710685003583 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 710685003584 substrate binding site; other site 710685003585 tetramer interface; other site 710685003586 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685003587 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685003588 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685003589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685003590 Cytochrome P450; Region: p450; cl12078 710685003591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003593 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 710685003594 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710685003595 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710685003596 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710685003597 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710685003598 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710685003599 trimer interface [polypeptide binding]; other site 710685003600 active site 710685003601 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 710685003602 active site 710685003603 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710685003604 dinuclear metal binding motif [ion binding]; other site 710685003605 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 710685003606 Secretory lipase; Region: LIP; pfam03583 710685003607 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685003608 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685003609 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685003610 active site 710685003611 ATP binding site [chemical binding]; other site 710685003612 substrate binding site [chemical binding]; other site 710685003613 activation loop (A-loop); other site 710685003614 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710685003615 NHL repeat; Region: NHL; pfam01436 710685003616 NHL repeat; Region: NHL; pfam01436 710685003617 NHL repeat; Region: NHL; pfam01436 710685003618 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 710685003619 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710685003620 DNA binding site [nucleotide binding] 710685003621 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685003622 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685003623 phosphopeptide binding site; other site 710685003624 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710685003625 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710685003626 active site 710685003627 iron coordination sites [ion binding]; other site 710685003628 substrate binding pocket [chemical binding]; other site 710685003629 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710685003630 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710685003631 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710685003632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685003633 GAF domain; Region: GAF; pfam01590 710685003634 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685003635 anti sigma factor interaction site; other site 710685003636 regulatory phosphorylation site [posttranslational modification]; other site 710685003637 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685003638 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710685003639 MASE1; Region: MASE1; cl17823 710685003640 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685003641 Domain of unknown function (DUF427); Region: DUF427; cl00998 710685003642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710685003643 Interferon-induced transmembrane protein; Region: CD225; pfam04505 710685003644 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710685003645 pyranose oxidase; Region: pyranose_ox; TIGR02462 710685003646 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685003647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685003648 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685003649 active site 710685003650 ATP binding site [chemical binding]; other site 710685003651 substrate binding site [chemical binding]; other site 710685003652 activation loop (A-loop); other site 710685003653 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685003654 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710685003655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003656 NAD(P) binding site [chemical binding]; other site 710685003657 active site 710685003658 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685003659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685003660 DNA-binding site [nucleotide binding]; DNA binding site 710685003661 FCD domain; Region: FCD; pfam07729 710685003662 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685003663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003664 acyl-activating enzyme (AAE) consensus motif; other site 710685003665 AMP binding site [chemical binding]; other site 710685003666 active site 710685003667 CoA binding site [chemical binding]; other site 710685003668 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 710685003669 intersubunit interface [polypeptide binding]; other site 710685003670 active site 710685003671 Zn2+ binding site [ion binding]; other site 710685003672 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685003673 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685003674 nucleotide binding site [chemical binding]; other site 710685003675 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685003676 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685003677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710685003678 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710685003679 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 710685003680 active site 710685003681 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710685003682 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710685003683 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710685003684 active site 710685003685 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710685003686 Eukaryotic porin family that forms channels in the mitochondrial outer membrane; Region: Porin3; cl03224 710685003687 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685003688 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685003689 active site 710685003690 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710685003691 Sulfatase; Region: Sulfatase; pfam00884 710685003692 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 710685003693 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 710685003694 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710685003695 Active Sites [active] 710685003696 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 710685003697 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 710685003698 CysD dimerization site [polypeptide binding]; other site 710685003699 G1 box; other site 710685003700 putative GEF interaction site [polypeptide binding]; other site 710685003701 GTP/Mg2+ binding site [chemical binding]; other site 710685003702 Switch I region; other site 710685003703 G2 box; other site 710685003704 G3 box; other site 710685003705 Switch II region; other site 710685003706 G4 box; other site 710685003707 G5 box; other site 710685003708 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 710685003709 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 710685003710 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 710685003711 ligand-binding site [chemical binding]; other site 710685003712 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 710685003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685003714 S-adenosylmethionine binding site [chemical binding]; other site 710685003715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685003716 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710685003717 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710685003718 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710685003719 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710685003720 active site 710685003721 catalytic residues [active] 710685003722 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710685003723 EspG family; Region: ESX-1_EspG; pfam14011 710685003724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 710685003725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710685003726 PPE family; Region: PPE; pfam00823 710685003727 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710685003728 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685003729 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710685003730 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685003731 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710685003732 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710685003733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685003734 Walker A motif; other site 710685003735 ATP binding site [chemical binding]; other site 710685003736 Walker B motif; other site 710685003737 arginine finger; other site 710685003738 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685003739 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685003740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685003741 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685003742 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685003743 cyclase homology domain; Region: CHD; cd07302 710685003744 nucleotidyl binding site; other site 710685003745 metal binding site [ion binding]; metal-binding site 710685003746 dimer interface [polypeptide binding]; other site 710685003747 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710685003748 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 710685003749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685003750 Zn binding site [ion binding]; other site 710685003751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003753 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 710685003754 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 710685003755 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 710685003756 putative ligand binding site [chemical binding]; other site 710685003757 putative NAD binding site [chemical binding]; other site 710685003758 catalytic site [active] 710685003759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685003760 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685003761 active site 710685003762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685003763 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710685003764 FAD binding site [chemical binding]; other site 710685003765 substrate binding site [chemical binding]; other site 710685003766 catalytic base [active] 710685003767 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685003768 classical (c) SDRs; Region: SDR_c; cd05233 710685003769 NAD(P) binding site [chemical binding]; other site 710685003770 active site 710685003771 acyl-CoA synthetase; Validated; Region: PRK07788 710685003772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003774 active site 710685003775 CoA binding site [chemical binding]; other site 710685003776 AMP binding site [chemical binding]; other site 710685003777 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710685003778 nucleotide binding site [chemical binding]; other site 710685003779 YacP-like NYN domain; Region: NYN_YacP; cl01491 710685003780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685003781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685003782 salt bridge; other site 710685003783 non-specific DNA binding site [nucleotide binding]; other site 710685003784 sequence-specific DNA binding site [nucleotide binding]; other site 710685003785 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710685003786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003787 NAD(P) binding site [chemical binding]; other site 710685003788 active site 710685003789 TIGR03086 family protein; Region: TIGR03086 710685003790 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685003791 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685003792 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 710685003793 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 710685003794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 710685003795 hypothetical protein; Provisional; Region: PRK06753 710685003796 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685003797 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 710685003798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685003799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710685003800 dimerization interface [polypeptide binding]; other site 710685003801 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 710685003802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685003803 putative substrate translocation pore; other site 710685003804 Lysine efflux permease [General function prediction only]; Region: COG1279 710685003805 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685003806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003807 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 710685003808 short chain dehydrogenase; Provisional; Region: PRK08267 710685003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003810 NAD(P) binding site [chemical binding]; other site 710685003811 active site 710685003812 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 710685003813 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710685003814 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710685003815 intersubunit interface [polypeptide binding]; other site 710685003816 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 710685003817 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 710685003818 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 710685003819 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 710685003820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685003821 Coenzyme A binding pocket [chemical binding]; other site 710685003822 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 710685003823 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710685003824 active site 710685003825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710685003826 DNA binding site [nucleotide binding] 710685003827 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710685003828 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710685003829 putative active site [active] 710685003830 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710685003831 putative active site [active] 710685003832 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 710685003833 E-class dimer interface [polypeptide binding]; other site 710685003834 P-class dimer interface [polypeptide binding]; other site 710685003835 active site 710685003836 Cu2+ binding site [ion binding]; other site 710685003837 Zn2+ binding site [ion binding]; other site 710685003838 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 710685003839 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 710685003840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685003841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685003842 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710685003843 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710685003844 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710685003845 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710685003846 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710685003847 putative dimer interface [polypeptide binding]; other site 710685003848 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710685003849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710685003850 tetramer interface [polypeptide binding]; other site 710685003851 active site 710685003852 Mg2+/Mn2+ binding site [ion binding]; other site 710685003853 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 710685003854 L-aspartate oxidase; Provisional; Region: PRK06175 710685003855 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710685003856 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 710685003857 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685003858 catalytic loop [active] 710685003859 iron binding site [ion binding]; other site 710685003860 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710685003861 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685003862 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685003863 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710685003864 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710685003865 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 710685003866 FAD binding site [chemical binding]; other site 710685003867 substrate binding site [chemical binding]; other site 710685003868 catalytic residues [active] 710685003869 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710685003870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685003871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685003872 dimer interface [polypeptide binding]; other site 710685003873 phosphorylation site [posttranslational modification] 710685003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685003875 ATP binding site [chemical binding]; other site 710685003876 Mg2+ binding site [ion binding]; other site 710685003877 G-X-G motif; other site 710685003878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685003879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685003880 active site 710685003881 phosphorylation site [posttranslational modification] 710685003882 intermolecular recognition site; other site 710685003883 dimerization interface [polypeptide binding]; other site 710685003884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685003885 DNA binding site [nucleotide binding] 710685003886 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710685003887 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710685003888 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 710685003889 active site clefts [active] 710685003890 zinc binding site [ion binding]; other site 710685003891 dimer interface [polypeptide binding]; other site 710685003892 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685003893 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685003894 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 710685003895 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 710685003896 gating phenylalanine in ion channel; other site 710685003897 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 710685003898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685003899 dimer interface [polypeptide binding]; other site 710685003900 active site 710685003901 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 710685003902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003903 active site 710685003904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685003905 NAD(P) binding site [chemical binding]; other site 710685003906 active site 710685003907 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685003908 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685003909 active site 2 [active] 710685003910 active site 1 [active] 710685003911 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685003912 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685003913 homodimer interface [polypeptide binding]; other site 710685003914 active site 710685003915 TDP-binding site; other site 710685003916 acceptor substrate-binding pocket; other site 710685003917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685003918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685003919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710685003920 Walker A/P-loop; other site 710685003921 ATP binding site [chemical binding]; other site 710685003922 Q-loop/lid; other site 710685003923 ABC transporter signature motif; other site 710685003924 Walker B; other site 710685003925 D-loop; other site 710685003926 H-loop/switch region; other site 710685003927 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 710685003928 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 710685003929 active site 710685003930 zinc binding site [ion binding]; other site 710685003931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003933 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710685003934 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710685003935 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 710685003936 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 710685003937 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 710685003938 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 710685003939 active site 710685003940 substrate binding pocket [chemical binding]; other site 710685003941 homodimer interaction site [polypeptide binding]; other site 710685003942 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710685003943 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003944 acyl-activating enzyme (AAE) consensus motif; other site 710685003945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685003946 AMP binding site [chemical binding]; other site 710685003947 active site 710685003948 acyl-activating enzyme (AAE) consensus motif; other site 710685003949 CoA binding site [chemical binding]; other site 710685003950 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685003951 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 710685003952 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685003953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685003954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685003955 S-adenosylmethionine binding site [chemical binding]; other site 710685003956 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710685003957 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685003958 NAD binding site [chemical binding]; other site 710685003959 catalytic residues [active] 710685003960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685003961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685003962 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710685003963 Helix-turn-helix domain; Region: HTH_18; pfam12833 710685003964 DinB superfamily; Region: DinB_2; pfam12867 710685003965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685003966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685003967 active site 710685003968 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685003969 active site 710685003970 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 710685003971 enoyl-CoA hydratase; Provisional; Region: PRK08252 710685003972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685003973 substrate binding site [chemical binding]; other site 710685003974 oxyanion hole (OAH) forming residues; other site 710685003975 trimer interface [polypeptide binding]; other site 710685003976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685003977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685003978 active site 710685003979 ATP binding site [chemical binding]; other site 710685003980 substrate binding site [chemical binding]; other site 710685003981 activation loop (A-loop); other site 710685003982 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685003983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685003984 putative acyl-acceptor binding pocket; other site 710685003985 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710685003986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685003987 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 710685003988 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685003989 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685003990 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685003991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685003992 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685003993 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685003994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685003995 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685003996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685003997 active site 710685003998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685003999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004000 active site 710685004001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685004002 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685004003 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710685004004 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685004005 active site 710685004006 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685004007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685004008 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685004009 active site 2 [active] 710685004010 active site 1 [active] 710685004011 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685004012 active site 2 [active] 710685004013 active site 1 [active] 710685004014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685004015 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004016 active site 710685004017 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710685004018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685004019 DNA-binding site [nucleotide binding]; DNA binding site 710685004020 UTRA domain; Region: UTRA; cl17743 710685004021 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685004022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685004023 substrate binding site [chemical binding]; other site 710685004024 oxyanion hole (OAH) forming residues; other site 710685004025 trimer interface [polypeptide binding]; other site 710685004026 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710685004027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685004028 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685004029 acyl-activating enzyme (AAE) consensus motif; other site 710685004030 putative AMP binding site [chemical binding]; other site 710685004031 putative active site [active] 710685004032 putative CoA binding site [chemical binding]; other site 710685004033 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685004034 cyclase homology domain; Region: CHD; cd07302 710685004035 nucleotidyl binding site; other site 710685004036 metal binding site [ion binding]; metal-binding site 710685004037 dimer interface [polypeptide binding]; other site 710685004038 Predicted ATPase [General function prediction only]; Region: COG3903 710685004039 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 710685004040 active site 710685004041 substrate-binding site [chemical binding]; other site 710685004042 metal-binding site [ion binding] 710685004043 GTP binding site [chemical binding]; other site 710685004044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004045 S-adenosylmethionine binding site [chemical binding]; other site 710685004046 LabA_like proteins; Region: LabA_like; cd06167 710685004047 putative metal binding site [ion binding]; other site 710685004048 MMPL family; Region: MMPL; pfam03176 710685004049 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710685004050 MMPL family; Region: MMPL; pfam03176 710685004051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710685004052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710685004053 Predicted integral membrane protein [Function unknown]; Region: COG0392 710685004054 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710685004055 Peptidase family M23; Region: Peptidase_M23; pfam01551 710685004056 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 710685004057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685004058 HAMP domain; Region: HAMP; pfam00672 710685004059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685004060 phosphorylation site [posttranslational modification] 710685004061 dimer interface [polypeptide binding]; other site 710685004062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685004063 ATP binding site [chemical binding]; other site 710685004064 Mg2+ binding site [ion binding]; other site 710685004065 G-X-G motif; other site 710685004066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685004067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685004068 active site 710685004069 phosphorylation site [posttranslational modification] 710685004070 intermolecular recognition site; other site 710685004071 dimerization interface [polypeptide binding]; other site 710685004072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685004073 DNA binding site [nucleotide binding] 710685004074 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685004075 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 710685004076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685004077 non-specific DNA binding site [nucleotide binding]; other site 710685004078 salt bridge; other site 710685004079 sequence-specific DNA binding site [nucleotide binding]; other site 710685004080 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 710685004081 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 710685004082 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 710685004083 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 710685004084 active site 710685004085 Zn binding site [ion binding]; other site 710685004086 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685004087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685004088 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685004089 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710685004090 putative homotetramer interface [polypeptide binding]; other site 710685004091 putative homodimer interface [polypeptide binding]; other site 710685004092 putative allosteric switch controlling residues; other site 710685004093 putative metal binding site [ion binding]; other site 710685004094 putative homodimer-homodimer interface [polypeptide binding]; other site 710685004095 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710685004096 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 710685004097 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685004098 hydrophobic ligand binding site; other site 710685004099 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685004100 FAD binding domain; Region: FAD_binding_4; pfam01565 710685004101 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685004102 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710685004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004104 S-adenosylmethionine binding site [chemical binding]; other site 710685004105 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 710685004106 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 710685004107 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710685004108 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685004109 RNA polymerase factor sigma-70; Validated; Region: PRK08241 710685004110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685004111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685004112 DNA binding residues [nucleotide binding] 710685004113 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710685004114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685004115 MarR family; Region: MarR_2; pfam12802 710685004116 Pirin-related protein [General function prediction only]; Region: COG1741 710685004117 Pirin; Region: Pirin; pfam02678 710685004118 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710685004119 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 710685004120 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685004121 hydrophobic ligand binding site; other site 710685004122 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 710685004123 Fructosamine kinase; Region: Fructosamin_kin; cl17579 710685004124 Phosphotransferase enzyme family; Region: APH; pfam01636 710685004125 short chain dehydrogenase; Provisional; Region: PRK06914 710685004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685004127 NAD(P) binding site [chemical binding]; other site 710685004128 active site 710685004129 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685004130 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710685004131 RDD family; Region: RDD; pfam06271 710685004132 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685004133 mce related protein; Region: MCE; pfam02470 710685004134 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685004135 mce related protein; Region: MCE; pfam02470 710685004136 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685004137 mce related protein; Region: MCE; pfam02470 710685004138 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685004139 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685004140 mce related protein; Region: MCE; pfam02470 710685004141 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710685004142 mce related protein; Region: MCE; pfam02470 710685004143 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685004144 mce related protein; Region: MCE; pfam02470 710685004145 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685004146 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685004147 Permease; Region: Permease; pfam02405 710685004148 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685004149 Permease; Region: Permease; pfam02405 710685004150 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 710685004151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685004152 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685004153 acyl-activating enzyme (AAE) consensus motif; other site 710685004154 acyl-activating enzyme (AAE) consensus motif; other site 710685004155 putative AMP binding site [chemical binding]; other site 710685004156 putative active site [active] 710685004157 putative CoA binding site [chemical binding]; other site 710685004158 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710685004159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685004160 DNA-binding site [nucleotide binding]; DNA binding site 710685004161 FCD domain; Region: FCD; pfam07729 710685004162 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685004163 putative hydrophobic ligand binding site [chemical binding]; other site 710685004164 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710685004165 active site 710685004166 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710685004167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004168 S-adenosylmethionine binding site [chemical binding]; other site 710685004169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685004170 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685004171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685004172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685004173 DNA binding residues [nucleotide binding] 710685004174 dimerization interface [polypeptide binding]; other site 710685004175 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 710685004176 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685004177 NAD(P) binding site [chemical binding]; other site 710685004178 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710685004179 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710685004180 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710685004181 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710685004182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004183 active site 710685004184 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710685004185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004187 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 710685004188 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 710685004189 ligand binding site [chemical binding]; other site 710685004190 homodimer interface [polypeptide binding]; other site 710685004191 NAD(P) binding site [chemical binding]; other site 710685004192 trimer interface B [polypeptide binding]; other site 710685004193 trimer interface A [polypeptide binding]; other site 710685004194 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 710685004195 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 710685004196 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 710685004197 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685004198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004199 active site 710685004200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685004201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685004202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685004203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685004204 ATP binding site [chemical binding]; other site 710685004205 Mg2+ binding site [ion binding]; other site 710685004206 G-X-G motif; other site 710685004207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685004208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685004209 active site 710685004210 phosphorylation site [posttranslational modification] 710685004211 intermolecular recognition site; other site 710685004212 dimerization interface [polypeptide binding]; other site 710685004213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685004214 DNA binding residues [nucleotide binding] 710685004215 dimerization interface [polypeptide binding]; other site 710685004216 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 710685004217 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685004218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685004219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004220 active site 710685004221 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 710685004222 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 710685004223 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 710685004224 Protein of unknown function (DUF456); Region: DUF456; pfam04306 710685004225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004226 S-adenosylmethionine binding site [chemical binding]; other site 710685004227 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710685004228 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 710685004229 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685004230 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710685004231 NAD(P) binding site [chemical binding]; other site 710685004232 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685004233 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 710685004234 homodimer interface [polypeptide binding]; other site 710685004235 NAD binding site [chemical binding]; other site 710685004236 active site 710685004237 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710685004238 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 710685004239 NAD(P) binding site [chemical binding]; other site 710685004240 catalytic residues [active] 710685004241 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685004242 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710685004243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004247 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710685004248 Pirin-related protein [General function prediction only]; Region: COG1741 710685004249 Pirin; Region: Pirin; pfam02678 710685004250 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710685004251 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710685004252 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 710685004253 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710685004254 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710685004255 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710685004256 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 710685004257 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710685004258 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710685004259 putative substrate binding site [chemical binding]; other site 710685004260 putative ATP binding site [chemical binding]; other site 710685004261 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710685004262 active site 710685004263 phosphorylation site [posttranslational modification] 710685004264 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 710685004265 active site 710685004266 P-loop; other site 710685004267 phosphorylation site [posttranslational modification] 710685004268 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 710685004269 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710685004270 dimerization domain swap beta strand [polypeptide binding]; other site 710685004271 regulatory protein interface [polypeptide binding]; other site 710685004272 active site 710685004273 regulatory phosphorylation site [posttranslational modification]; other site 710685004274 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710685004275 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710685004276 active site 710685004277 catalytic residues [active] 710685004278 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710685004279 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 710685004280 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 710685004281 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 710685004282 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 710685004283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685004284 active site 710685004285 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710685004286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685004287 Walker A/P-loop; other site 710685004288 ATP binding site [chemical binding]; other site 710685004289 Q-loop/lid; other site 710685004290 ABC transporter signature motif; other site 710685004291 Walker B; other site 710685004292 D-loop; other site 710685004293 H-loop/switch region; other site 710685004294 TOBE domain; Region: TOBE_2; pfam08402 710685004295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685004296 dimer interface [polypeptide binding]; other site 710685004297 conserved gate region; other site 710685004298 putative PBP binding loops; other site 710685004299 ABC-ATPase subunit interface; other site 710685004300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710685004301 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710685004302 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710685004303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004305 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 710685004306 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 710685004307 elongation factor G; Reviewed; Region: PRK12740 710685004308 G1 box; other site 710685004309 putative GEF interaction site [polypeptide binding]; other site 710685004310 GTP/Mg2+ binding site [chemical binding]; other site 710685004311 Switch I region; other site 710685004312 G2 box; other site 710685004313 G3 box; other site 710685004314 Switch II region; other site 710685004315 G4 box; other site 710685004316 G5 box; other site 710685004317 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710685004318 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710685004319 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710685004320 Uncharacterized conserved protein [Function unknown]; Region: COG1434 710685004321 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 710685004322 putative active site [active] 710685004323 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685004324 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710685004325 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286 710685004326 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 710685004327 active site 710685004328 catalytic triad [active] 710685004329 calcium binding site [ion binding]; other site 710685004330 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685004331 anti sigma factor interaction site; other site 710685004332 regulatory phosphorylation site [posttranslational modification]; other site 710685004333 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 710685004334 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 710685004335 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 710685004336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685004337 ATP binding site [chemical binding]; other site 710685004338 Mg2+ binding site [ion binding]; other site 710685004339 G-X-G motif; other site 710685004340 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 710685004341 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 710685004342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710685004343 PAS domain; Region: PAS_9; pfam13426 710685004344 putative active site [active] 710685004345 heme pocket [chemical binding]; other site 710685004346 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685004347 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685004348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685004349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685004352 metabolite-proton symporter; Region: 2A0106; TIGR00883 710685004353 putative substrate translocation pore; other site 710685004354 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710685004355 Protein of unknown function DUF58; Region: DUF58; pfam01882 710685004356 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685004357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685004358 Walker A motif; other site 710685004359 ATP binding site [chemical binding]; other site 710685004360 Walker B motif; other site 710685004361 arginine finger; other site 710685004362 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710685004363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004364 S-adenosylmethionine binding site [chemical binding]; other site 710685004365 K+ potassium transporter; Region: K_trans; pfam02705 710685004366 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685004367 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685004368 active site 710685004369 GtrA-like protein; Region: GtrA; pfam04138 710685004370 Rhomboid family; Region: Rhomboid; pfam01694 710685004371 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685004372 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710685004373 FMN binding site [chemical binding]; other site 710685004374 dimer interface [polypeptide binding]; other site 710685004375 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685004376 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685004377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710685004378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685004379 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685004380 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 710685004381 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 710685004382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685004383 ATP binding site [chemical binding]; other site 710685004384 putative Mg++ binding site [ion binding]; other site 710685004385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685004386 nucleotide binding region [chemical binding]; other site 710685004387 Helicase associated domain (HA2); Region: HA2; pfam04408 710685004388 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 710685004389 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 710685004390 Uncharacterized conserved protein [Function unknown]; Region: COG0397 710685004391 hypothetical protein; Validated; Region: PRK00029 710685004392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685004393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685004394 DNA binding residues [nucleotide binding] 710685004395 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685004396 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685004397 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710685004398 putative FMN binding site [chemical binding]; other site 710685004399 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710685004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685004401 NAD(P) binding site [chemical binding]; other site 710685004402 active site 710685004403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004404 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710685004405 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710685004406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710685004407 putative active site [active] 710685004408 putative metal binding site [ion binding]; other site 710685004409 Part of AAA domain; Region: AAA_19; pfam13245 710685004410 Family description; Region: UvrD_C_2; pfam13538 710685004411 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710685004412 putative active site [active] 710685004413 putative CoA binding site [chemical binding]; other site 710685004414 nudix motif; other site 710685004415 metal binding site [ion binding]; metal-binding site 710685004416 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710685004417 MarR family; Region: MarR_2; pfam12802 710685004418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685004419 putative substrate translocation pore; other site 710685004420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685004421 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685004422 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685004423 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685004424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685004425 Zn2+ binding site [ion binding]; other site 710685004426 Mg2+ binding site [ion binding]; other site 710685004427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685004428 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685004429 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685004430 active site 710685004431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685004432 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685004433 active site 710685004434 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685004435 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685004436 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685004437 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685004438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710685004439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685004440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710685004441 dimerization interface [polypeptide binding]; other site 710685004442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710685004443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685004444 ATP binding site [chemical binding]; other site 710685004445 putative Mg++ binding site [ion binding]; other site 710685004446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685004447 nucleotide binding region [chemical binding]; other site 710685004448 ATP-binding site [chemical binding]; other site 710685004449 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 710685004450 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685004451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685004452 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685004453 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685004454 active site 710685004455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685004456 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 710685004457 putative substrate translocation pore; other site 710685004458 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 710685004459 active site 710685004460 catalytic residues [active] 710685004461 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 710685004462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685004463 S-adenosylmethionine binding site [chemical binding]; other site 710685004464 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685004465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685004466 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685004467 classical (c) SDRs; Region: SDR_c; cd05233 710685004468 NAD(P) binding site [chemical binding]; other site 710685004469 active site 710685004470 FAD binding domain; Region: FAD_binding_4; pfam01565 710685004471 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710685004472 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685004473 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 710685004474 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 710685004475 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 710685004476 benzoylformate decarboxylase; Reviewed; Region: PRK07092 710685004477 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685004478 PYR/PP interface [polypeptide binding]; other site 710685004479 dimer interface [polypeptide binding]; other site 710685004480 TPP binding site [chemical binding]; other site 710685004481 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685004482 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 710685004483 TPP-binding site [chemical binding]; other site 710685004484 dimer interface [polypeptide binding]; other site 710685004485 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710685004486 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 710685004487 Protein of unknown function DUF58; Region: DUF58; pfam01882 710685004488 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685004489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685004490 ATP binding site [chemical binding]; other site 710685004491 Walker A motif; other site 710685004492 Walker B motif; other site 710685004493 arginine finger; other site 710685004494 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685004495 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685004496 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685004497 active site 710685004498 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685004499 catalytic triad [active] 710685004500 dimer interface [polypeptide binding]; other site 710685004501 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710685004502 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710685004503 putative active site [active] 710685004504 putative metal binding site [ion binding]; other site 710685004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 710685004506 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710685004507 Amidase; Region: Amidase; cl11426 710685004508 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685004509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685004510 substrate binding site [chemical binding]; other site 710685004511 oxyanion hole (OAH) forming residues; other site 710685004512 trimer interface [polypeptide binding]; other site 710685004513 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 710685004514 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 710685004515 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 710685004516 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 710685004517 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685004518 active site 710685004519 catalytic site [active] 710685004520 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685004521 active site 2 [active] 710685004522 active site 1 [active] 710685004523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685004524 short chain dehydrogenase; Validated; Region: PRK08264 710685004525 NAD(P) binding site [chemical binding]; other site 710685004526 active site 710685004527 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685004528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685004529 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 710685004530 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710685004531 active site 710685004532 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 710685004533 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 710685004534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710685004535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685004536 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685004537 classical (c) SDRs; Region: SDR_c; cd05233 710685004538 NAD(P) binding site [chemical binding]; other site 710685004539 active site 710685004540 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 710685004541 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 710685004542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685004543 TIGR03085 family protein; Region: TIGR03085 710685004544 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710685004545 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 710685004546 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710685004547 putative active site [active] 710685004548 putative active site [active] 710685004549 catalytic site [active] 710685004550 catalytic site [active] 710685004551 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 710685004552 putative active site [active] 710685004553 catalytic site [active] 710685004554 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 710685004555 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 710685004556 Isochorismatase family; Region: Isochorismatase; pfam00857 710685004557 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710685004558 catalytic triad [active] 710685004559 conserved cis-peptide bond; other site 710685004560 oxidoreductase; Provisional; Region: PRK06196 710685004561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685004562 NAD(P) binding site [chemical binding]; other site 710685004563 active site 710685004564 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 710685004565 lycopene cyclase; Region: lycopene_cycl; TIGR01789 710685004566 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 710685004567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004569 WHG domain; Region: WHG; pfam13305 710685004570 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 710685004571 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 710685004572 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710685004573 Protein of unknown function, DUF488; Region: DUF488; pfam04343 710685004574 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 710685004575 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710685004576 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 710685004577 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 710685004578 putative heme binding pocket [chemical binding]; other site 710685004579 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 710685004580 thioester formation/cholesterol transfer; other site 710685004581 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 710685004582 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710685004583 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710685004584 Walker A motif; other site 710685004585 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 710685004586 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710685004587 ATP binding site [chemical binding]; other site 710685004588 Walker B motif; other site 710685004589 DNA binding loops [nucleotide binding] 710685004590 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710685004591 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710685004592 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710685004593 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 710685004594 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710685004595 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710685004596 dimer interface [polypeptide binding]; other site 710685004597 ssDNA binding site [nucleotide binding]; other site 710685004598 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710685004599 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 710685004600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685004601 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710685004602 cyclase homology domain; Region: CHD; cd07302 710685004603 nucleotidyl binding site; other site 710685004604 metal binding site [ion binding]; metal-binding site 710685004605 dimer interface [polypeptide binding]; other site 710685004606 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710685004607 active site 710685004608 catalytic triad [active] 710685004609 oxyanion hole [active] 710685004610 Predicted integral membrane protein [Function unknown]; Region: COG5650 710685004611 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710685004612 Transglycosylase; Region: Transgly; pfam00912 710685004613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710685004614 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710685004615 Predicted transcriptional regulators [Transcription]; Region: COG1695 710685004616 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710685004617 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 710685004618 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 710685004619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685004620 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710685004621 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 710685004622 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710685004623 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685004624 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685004625 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710685004626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685004627 DNA-binding site [nucleotide binding]; DNA binding site 710685004628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685004629 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685004630 substrate binding pocket [chemical binding]; other site 710685004631 membrane-bound complex binding site; other site 710685004632 hinge residues; other site 710685004633 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710685004634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685004635 dimer interface [polypeptide binding]; other site 710685004636 conserved gate region; other site 710685004637 putative PBP binding loops; other site 710685004638 ABC-ATPase subunit interface; other site 710685004639 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685004640 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710685004641 Walker A/P-loop; other site 710685004642 ATP binding site [chemical binding]; other site 710685004643 Q-loop/lid; other site 710685004644 ABC transporter signature motif; other site 710685004645 Walker B; other site 710685004646 D-loop; other site 710685004647 H-loop/switch region; other site 710685004648 MarR family; Region: MarR; pfam01047 710685004649 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 710685004650 short chain dehydrogenase; Provisional; Region: PRK08219 710685004651 classical (c) SDRs; Region: SDR_c; cd05233 710685004652 NAD(P) binding site [chemical binding]; other site 710685004653 active site 710685004654 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710685004655 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685004656 putative active site [active] 710685004657 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 710685004658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685004659 active site 710685004660 HIGH motif; other site 710685004661 nucleotide binding site [chemical binding]; other site 710685004662 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710685004663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685004664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685004665 active site 710685004666 KMSKS motif; other site 710685004667 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 710685004668 tRNA binding surface [nucleotide binding]; other site 710685004669 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710685004670 hypothetical protein; Validated; Region: PRK00228 710685004671 TIGR03084 family protein; Region: TIGR03084 710685004672 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685004673 Wyosine base formation; Region: Wyosine_form; pfam08608 710685004674 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 710685004675 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 710685004676 active site 710685004677 NTP binding site [chemical binding]; other site 710685004678 metal binding triad [ion binding]; metal-binding site 710685004679 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 710685004680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685004681 Zn2+ binding site [ion binding]; other site 710685004682 Mg2+ binding site [ion binding]; other site 710685004683 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710685004684 active site 710685004685 Ap6A binding site [chemical binding]; other site 710685004686 nudix motif; other site 710685004687 metal binding site [ion binding]; metal-binding site 710685004688 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 710685004689 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 710685004690 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 710685004691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685004692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685004693 DNA binding residues [nucleotide binding] 710685004694 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710685004695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685004696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685004697 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710685004698 catalytic residues [active] 710685004699 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710685004700 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710685004701 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710685004702 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710685004703 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710685004704 active site 710685004705 metal binding site [ion binding]; metal-binding site 710685004706 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 710685004707 ParB-like nuclease domain; Region: ParB; smart00470 710685004708 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710685004709 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685004710 P-loop; other site 710685004711 Magnesium ion binding site [ion binding]; other site 710685004712 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685004713 Magnesium ion binding site [ion binding]; other site 710685004714 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 710685004715 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 710685004716 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 710685004717 G-X-X-G motif; other site 710685004718 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 710685004719 RxxxH motif; other site 710685004720 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 710685004721 Uncharacterized conserved protein [Function unknown]; Region: COG0759 710685004722 ribonuclease P; Reviewed; Region: rnpA; PRK00588 710685004723 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 710685004724 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 710685004725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685004726 Walker A motif; other site 710685004727 ATP binding site [chemical binding]; other site 710685004728 Walker B motif; other site 710685004729 arginine finger; other site 710685004730 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710685004731 DnaA box-binding interface [nucleotide binding]; other site 710685004732 DNA polymerase III subunit beta; Validated; Region: PRK07761 710685004733 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 710685004734 putative DNA binding surface [nucleotide binding]; other site 710685004735 dimer interface [polypeptide binding]; other site 710685004736 beta-clamp/clamp loader binding surface; other site 710685004737 beta-clamp/translesion DNA polymerase binding surface; other site 710685004738 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685004739 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 710685004740 recombination protein F; Reviewed; Region: recF; PRK00064 710685004741 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 710685004742 Walker A/P-loop; other site 710685004743 ATP binding site [chemical binding]; other site 710685004744 Q-loop/lid; other site 710685004745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685004746 ABC transporter signature motif; other site 710685004747 Walker B; other site 710685004748 D-loop; other site 710685004749 H-loop/switch region; other site 710685004750 hypothetical protein; Provisional; Region: PRK03195 710685004751 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710685004752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685004753 Mg2+ binding site [ion binding]; other site 710685004754 G-X-G motif; other site 710685004755 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710685004756 anchoring element; other site 710685004757 dimer interface [polypeptide binding]; other site 710685004758 ATP binding site [chemical binding]; other site 710685004759 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710685004760 active site 710685004761 putative metal-binding site [ion binding]; other site 710685004762 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710685004763 DNA gyrase subunit A; Validated; Region: PRK05560 710685004764 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710685004765 CAP-like domain; other site 710685004766 active site 710685004767 primary dimer interface [polypeptide binding]; other site 710685004768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004772 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004773 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710685004774 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 710685004775 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685004776 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685004777 cyclase homology domain; Region: CHD; cd07302 710685004778 nucleotidyl binding site; other site 710685004779 metal binding site [ion binding]; metal-binding site 710685004780 dimer interface [polypeptide binding]; other site 710685004781 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 710685004782 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710685004783 active site 710685004784 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710685004785 putative septation inhibitor protein; Reviewed; Region: PRK00159 710685004786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710685004787 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 710685004788 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710685004789 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 710685004790 Glutamine amidotransferase class-I; Region: GATase; pfam00117 710685004791 glutamine binding [chemical binding]; other site 710685004792 catalytic triad [active] 710685004793 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685004794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685004795 active site 710685004796 ATP binding site [chemical binding]; other site 710685004797 substrate binding site [chemical binding]; other site 710685004798 activation loop (A-loop); other site 710685004799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 710685004800 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710685004801 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710685004802 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710685004803 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710685004804 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685004805 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685004806 active site 710685004807 ATP binding site [chemical binding]; other site 710685004808 substrate binding site [chemical binding]; other site 710685004809 activation loop (A-loop); other site 710685004810 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710685004811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710685004812 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 710685004813 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710685004814 active site 710685004815 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685004816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685004817 phosphopeptide binding site; other site 710685004818 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 710685004819 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685004820 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685004821 phosphopeptide binding site; other site 710685004822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004823 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685004824 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685004825 molybdopterin cofactor binding site; other site 710685004826 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710685004827 putative molybdopterin cofactor binding site; other site 710685004828 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685004829 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685004830 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685004831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685004832 active site 710685004833 ATP binding site [chemical binding]; other site 710685004834 substrate binding site [chemical binding]; other site 710685004835 activation loop (A-loop); other site 710685004836 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685004837 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685004838 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685004839 CoenzymeA binding site [chemical binding]; other site 710685004840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685004841 Coenzyme A binding pocket [chemical binding]; other site 710685004842 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 710685004843 Pirin-related protein [General function prediction only]; Region: COG1741 710685004844 Pirin; Region: Pirin; pfam02678 710685004845 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710685004846 hypothetical protein; Provisional; Region: PRK02268 710685004847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685004848 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685004849 active site 710685004850 ATP binding site [chemical binding]; other site 710685004851 substrate binding site [chemical binding]; other site 710685004852 activation loop (A-loop); other site 710685004853 Predicted membrane protein [Function unknown]; Region: COG3428 710685004854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685004855 MarR family; Region: MarR; pfam01047 710685004856 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685004857 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685004858 Transcription factor WhiB; Region: Whib; pfam02467 710685004859 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710685004860 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710685004861 EspG family; Region: ESX-1_EspG; pfam14011 710685004862 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710685004863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685004864 Walker A motif; other site 710685004865 ATP binding site [chemical binding]; other site 710685004866 Walker B motif; other site 710685004867 arginine finger; other site 710685004868 Protein of unknown function (DUF690); Region: DUF690; pfam05108 710685004869 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710685004870 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685004871 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710685004872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685004873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685004874 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710685004875 PPE family; Region: PPE; pfam00823 710685004876 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 710685004877 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710685004878 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710685004879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685004880 P-loop; other site 710685004881 Magnesium ion binding site [ion binding]; other site 710685004882 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 710685004883 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 710685004884 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710685004885 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710685004886 NodB motif; other site 710685004887 active site 710685004888 catalytic site [active] 710685004889 metal binding site [ion binding]; metal-binding site 710685004890 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685004891 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685004892 potassium/proton antiporter; Reviewed; Region: PRK05326 710685004893 TrkA-C domain; Region: TrkA_C; pfam02080 710685004894 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710685004895 TrkA-N domain; Region: TrkA_N; pfam02254 710685004896 TrkA-C domain; Region: TrkA_C; pfam02080 710685004897 TIGR03086 family protein; Region: TIGR03086 710685004898 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685004899 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710685004900 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 710685004901 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710685004902 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710685004903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685004904 dimerization interface [polypeptide binding]; other site 710685004905 putative DNA binding site [nucleotide binding]; other site 710685004906 putative Zn2+ binding site [ion binding]; other site 710685004907 hypothetical protein; Provisional; Region: PRK07945 710685004908 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 710685004909 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 710685004910 active site 710685004911 yiaA/B two helix domain; Region: YiaAB; cl01759 710685004912 DNA polymerase IV; Validated; Region: PRK03858 710685004913 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710685004914 active site 710685004915 DNA binding site [nucleotide binding] 710685004916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685004917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685004918 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685004919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685004920 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 710685004921 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 710685004922 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 710685004923 DNA binding residues [nucleotide binding] 710685004924 dimer interface [polypeptide binding]; other site 710685004925 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 710685004926 Copper resistance protein D; Region: CopD; cl00563 710685004927 CopC domain; Region: CopC; pfam04234 710685004928 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 710685004929 Domain of unknown function (DUF955); Region: DUF955; cl01076 710685004930 Predicted membrane protein [Function unknown]; Region: COG2119 710685004931 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710685004932 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710685004933 yybP-ykoY leader 710685004934 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710685004935 Catalytic site [active] 710685004936 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 710685004937 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685004938 active site residue [active] 710685004939 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 710685004940 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 710685004941 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 710685004942 putative active site [active] 710685004943 catalytic site [active] 710685004944 putative metal binding site [ion binding]; other site 710685004945 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 710685004946 Ferritin-like domain; Region: Ferritin; pfam00210 710685004947 ferroxidase diiron center [ion binding]; other site 710685004948 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710685004949 CAAX protease self-immunity; Region: Abi; pfam02517 710685004950 prephenate dehydratase; Provisional; Region: PRK11898 710685004951 Prephenate dehydratase; Region: PDT; pfam00800 710685004952 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 710685004953 putative L-Phe binding site [chemical binding]; other site 710685004954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685004955 catalytic core [active] 710685004956 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 710685004957 Septum formation; Region: Septum_form; pfam13845 710685004958 Septum formation; Region: Septum_form; pfam13845 710685004959 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710685004960 seryl-tRNA synthetase; Provisional; Region: PRK05431 710685004961 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710685004962 dimer interface [polypeptide binding]; other site 710685004963 active site 710685004964 motif 1; other site 710685004965 motif 2; other site 710685004966 motif 3; other site 710685004967 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710685004968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685004969 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685004970 iron-sulfur cluster [ion binding]; other site 710685004971 [2Fe-2S] cluster binding site [ion binding]; other site 710685004972 Predicted ATPase [General function prediction only]; Region: COG3910 710685004973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685004974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 710685004975 Walker A/P-loop; other site 710685004976 Walker A/P-loop; other site 710685004977 ATP binding site [chemical binding]; other site 710685004978 ATP binding site [chemical binding]; other site 710685004979 Q-loop/lid; other site 710685004980 ABC transporter signature motif; other site 710685004981 Walker B; other site 710685004982 D-loop; other site 710685004983 H-loop/switch region; other site 710685004984 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685004985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685004986 putative acyl-acceptor binding pocket; other site 710685004987 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685004988 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685004989 putative acyl-acceptor binding pocket; other site 710685004990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685004991 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710685004992 active site 710685004993 motif I; other site 710685004994 motif II; other site 710685004995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685004996 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710685004997 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 710685004998 amidase catalytic site [active] 710685004999 Zn binding residues [ion binding]; other site 710685005000 substrate binding site [chemical binding]; other site 710685005001 LGFP repeat; Region: LGFP; pfam08310 710685005002 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 710685005003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685005004 UDP-galactopyranose mutase; Region: GLF; pfam03275 710685005005 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710685005006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685005007 active site 710685005008 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710685005009 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 710685005010 Putative esterase; Region: Esterase; pfam00756 710685005011 Putative esterase; Region: Esterase; pfam00756 710685005012 Cutinase; Region: Cutinase; pfam01083 710685005013 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 710685005014 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710685005015 acyl-activating enzyme (AAE) consensus motif; other site 710685005016 active site 710685005017 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685005018 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710685005019 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710685005020 active site 710685005021 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710685005022 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710685005023 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685005024 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 710685005025 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685005026 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685005027 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685005028 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 710685005029 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685005030 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685005031 active site 710685005032 ATP binding site [chemical binding]; other site 710685005033 substrate binding site [chemical binding]; other site 710685005034 activation loop (A-loop); other site 710685005035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685005036 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710685005037 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710685005038 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710685005039 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 710685005040 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 710685005041 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685005042 classical (c) SDRs; Region: SDR_c; cd05233 710685005043 NAD(P) binding site [chemical binding]; other site 710685005044 active site 710685005045 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685005046 FAD binding domain; Region: FAD_binding_4; pfam01565 710685005047 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 710685005048 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710685005049 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710685005050 Predicted membrane protein [Function unknown]; Region: COG2246 710685005051 GtrA-like protein; Region: GtrA; pfam04138 710685005052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685005053 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710685005054 DNA-binding site [nucleotide binding]; DNA binding site 710685005055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685005056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685005057 homodimer interface [polypeptide binding]; other site 710685005058 catalytic residue [active] 710685005059 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685005060 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685005061 Phosphotransferase enzyme family; Region: APH; pfam01636 710685005062 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 710685005063 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685005064 Winged helix-turn helix; Region: HTH_29; pfam13551 710685005065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710685005066 Integrase core domain; Region: rve; pfam00665 710685005067 Integrase core domain; Region: rve_3; pfam13683 710685005068 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 710685005069 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710685005070 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710685005071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685005072 active site 710685005073 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 710685005074 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 710685005075 Walker A/P-loop; other site 710685005076 ATP binding site [chemical binding]; other site 710685005077 Q-loop/lid; other site 710685005078 ABC transporter signature motif; other site 710685005079 Walker B; other site 710685005080 D-loop; other site 710685005081 H-loop/switch region; other site 710685005082 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 710685005083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710685005084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685005085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685005086 catalytic residue [active] 710685005087 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 710685005088 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 710685005089 NAD(P) binding site [chemical binding]; other site 710685005090 MarR family; Region: MarR; pfam01047 710685005091 MarR family; Region: MarR_2; cl17246 710685005092 Predicted membrane protein [Function unknown]; Region: COG4425 710685005093 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710685005094 enoyl-CoA hydratase; Provisional; Region: PRK06142 710685005095 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685005096 substrate binding site [chemical binding]; other site 710685005097 oxyanion hole (OAH) forming residues; other site 710685005098 trimer interface [polypeptide binding]; other site 710685005099 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685005100 TIGR03086 family protein; Region: TIGR03086 710685005101 GXWXG protein; Region: GXWXG; pfam14231 710685005102 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 710685005103 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 710685005104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685005105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685005106 homodimer interface [polypeptide binding]; other site 710685005107 catalytic residue [active] 710685005108 Predicted membrane protein [Function unknown]; Region: COG2259 710685005109 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710685005110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685005111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685005112 DNA binding residues [nucleotide binding] 710685005113 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710685005114 iron-sulfur cluster [ion binding]; other site 710685005115 [2Fe-2S] cluster binding site [ion binding]; other site 710685005116 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 710685005117 active site 710685005118 metal binding site [ion binding]; metal-binding site 710685005119 homotetramer interface [polypeptide binding]; other site 710685005120 Protein of unknown function (DUF419); Region: DUF419; cl15265 710685005121 short chain dehydrogenase; Provisional; Region: PRK07825 710685005122 classical (c) SDRs; Region: SDR_c; cd05233 710685005123 NAD(P) binding site [chemical binding]; other site 710685005124 active site 710685005125 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 710685005126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685005127 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710685005128 apolar tunnel; other site 710685005129 heme binding site [chemical binding]; other site 710685005130 dimerization interface [polypeptide binding]; other site 710685005131 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685005132 classical (c) SDRs; Region: SDR_c; cd05233 710685005133 NAD(P) binding site [chemical binding]; other site 710685005134 active site 710685005135 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 710685005136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685005137 catalytic core [active] 710685005138 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685005139 putative active site [active] 710685005140 putative substrate binding site [chemical binding]; other site 710685005141 ATP binding site [chemical binding]; other site 710685005142 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 710685005143 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710685005144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685005145 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710685005146 Walker A/P-loop; other site 710685005147 ATP binding site [chemical binding]; other site 710685005148 Q-loop/lid; other site 710685005149 ABC transporter signature motif; other site 710685005150 Walker B; other site 710685005151 D-loop; other site 710685005152 H-loop/switch region; other site 710685005153 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710685005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685005155 putative PBP binding loops; other site 710685005156 dimer interface [polypeptide binding]; other site 710685005157 ABC-ATPase subunit interface; other site 710685005158 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 710685005159 prephenate dehydrogenase; Validated; Region: PRK06545 710685005160 prephenate dehydrogenase; Validated; Region: PRK08507 710685005161 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 710685005162 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710685005163 nucleoside/Zn binding site; other site 710685005164 dimer interface [polypeptide binding]; other site 710685005165 catalytic motif [active] 710685005166 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685005167 PAS fold; Region: PAS_2; pfam08446 710685005168 GAF domain; Region: GAF; pfam01590 710685005169 Phytochrome region; Region: PHY; pfam00360 710685005170 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685005171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710685005172 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685005173 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685005174 NAD(P) binding site [chemical binding]; other site 710685005175 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685005176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685005177 active site 710685005178 metal binding site [ion binding]; metal-binding site 710685005179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 710685005180 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685005181 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685005182 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710685005183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685005184 active site 710685005185 phosphorylation site [posttranslational modification] 710685005186 intermolecular recognition site; other site 710685005187 dimerization interface [polypeptide binding]; other site 710685005188 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685005189 CHASE3 domain; Region: CHASE3; pfam05227 710685005190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685005191 dimerization interface [polypeptide binding]; other site 710685005192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685005193 dimer interface [polypeptide binding]; other site 710685005194 phosphorylation site [posttranslational modification] 710685005195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685005196 ATP binding site [chemical binding]; other site 710685005197 Mg2+ binding site [ion binding]; other site 710685005198 G-X-G motif; other site 710685005199 Response regulator receiver domain; Region: Response_reg; pfam00072 710685005200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685005201 active site 710685005202 phosphorylation site [posttranslational modification] 710685005203 intermolecular recognition site; other site 710685005204 dimerization interface [polypeptide binding]; other site 710685005205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685005206 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685005207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685005208 ATP binding site [chemical binding]; other site 710685005209 Mg2+ binding site [ion binding]; other site 710685005210 G-X-G motif; other site 710685005211 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685005212 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710685005213 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710685005214 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 710685005215 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 710685005216 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710685005217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685005218 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685005219 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685005220 Integrase core domain; Region: rve; pfam00665 710685005221 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685005222 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710685005223 Walker A/P-loop; other site 710685005224 ATP binding site [chemical binding]; other site 710685005225 Q-loop/lid; other site 710685005226 ABC transporter signature motif; other site 710685005227 Walker B; other site 710685005228 D-loop; other site 710685005229 H-loop/switch region; other site 710685005230 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685005231 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685005232 substrate binding pocket [chemical binding]; other site 710685005233 membrane-bound complex binding site; other site 710685005234 hinge residues; other site 710685005235 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710685005236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685005237 dimer interface [polypeptide binding]; other site 710685005238 conserved gate region; other site 710685005239 putative PBP binding loops; other site 710685005240 ABC-ATPase subunit interface; other site 710685005241 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 710685005242 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 710685005243 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 710685005244 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 710685005245 active site 710685005246 HIGH motif; other site 710685005247 nucleotide binding site [chemical binding]; other site 710685005248 active site 710685005249 KMSKS motif; other site 710685005250 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685005251 hypothetical protein; Provisional; Region: PRK07588 710685005252 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710685005253 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710685005254 active site 710685005255 DNA binding site [nucleotide binding] 710685005256 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710685005257 DNA binding site [nucleotide binding] 710685005258 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710685005259 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685005260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685005261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685005262 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710685005263 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710685005264 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 710685005265 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 710685005266 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 710685005267 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 710685005268 tetramer interface [polypeptide binding]; other site 710685005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685005270 catalytic residue [active] 710685005271 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710685005272 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710685005273 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 710685005274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685005275 nucleotide binding site [chemical binding]; other site 710685005276 Short C-terminal domain; Region: SHOCT; pfam09851 710685005277 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 710685005278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685005279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685005280 motif II; other site 710685005281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685005282 dimerization interface [polypeptide binding]; other site 710685005283 putative DNA binding site [nucleotide binding]; other site 710685005284 putative Zn2+ binding site [ion binding]; other site 710685005285 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710685005286 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710685005287 active site 710685005288 DNA binding site [nucleotide binding] 710685005289 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710685005290 DNA binding site [nucleotide binding] 710685005291 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685005292 active site 710685005293 catalytic residues [active] 710685005294 DNA binding site [nucleotide binding] 710685005295 Int/Topo IB signature motif; other site 710685005296 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710685005297 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685005298 active site 710685005299 DNA binding site [nucleotide binding] 710685005300 Int/Topo IB signature motif; other site 710685005301 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 710685005302 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710685005303 DNA binding site [nucleotide binding] 710685005304 active site 710685005305 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710685005306 DNA binding site [nucleotide binding] 710685005307 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710685005308 nucleotide binding site [chemical binding]; other site 710685005309 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685005310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685005311 S-adenosylmethionine binding site [chemical binding]; other site 710685005312 Cutinase; Region: Cutinase; pfam01083 710685005313 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685005314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685005315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685005316 active site 710685005317 ATP binding site [chemical binding]; other site 710685005318 substrate binding site [chemical binding]; other site 710685005319 activation loop (A-loop); other site 710685005320 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685005321 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685005322 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685005323 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685005324 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685005325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685005326 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685005327 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685005328 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710685005329 protein binding site [polypeptide binding]; other site 710685005330 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 710685005331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685005332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685005333 catalytic residue [active] 710685005334 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 710685005335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685005336 Walker A motif; other site 710685005337 ATP binding site [chemical binding]; other site 710685005338 Walker B motif; other site 710685005339 arginine finger; other site 710685005340 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 710685005341 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685005343 S-adenosylmethionine binding site [chemical binding]; other site 710685005344 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685005345 FAD binding domain; Region: FAD_binding_4; pfam01565 710685005346 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685005347 hydrophobic ligand binding site; other site 710685005348 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710685005349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710685005350 active site 710685005351 metal binding site [ion binding]; metal-binding site 710685005352 hypothetical protein; Validated; Region: PRK00153 710685005353 recombination protein RecR; Reviewed; Region: recR; PRK00076 710685005354 RecR protein; Region: RecR; pfam02132 710685005355 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710685005356 putative active site [active] 710685005357 putative metal-binding site [ion binding]; other site 710685005358 tetramer interface [polypeptide binding]; other site 710685005359 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710685005360 catalytic triad [active] 710685005361 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 710685005362 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685005363 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 710685005364 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 710685005365 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710685005366 active site 710685005367 catalytic site [active] 710685005368 substrate binding site [chemical binding]; other site 710685005369 2-isopropylmalate synthase; Validated; Region: PRK03739 710685005370 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 710685005371 active site 710685005372 catalytic residues [active] 710685005373 metal binding site [ion binding]; metal-binding site 710685005374 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710685005375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685005376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685005377 non-specific DNA binding site [nucleotide binding]; other site 710685005378 salt bridge; other site 710685005379 sequence-specific DNA binding site [nucleotide binding]; other site 710685005380 Cupin domain; Region: Cupin_2; pfam07883 710685005381 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685005382 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710685005383 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 710685005384 active site 710685005385 FMN binding site [chemical binding]; other site 710685005386 substrate binding site [chemical binding]; other site 710685005387 3Fe-4S cluster binding site [ion binding]; other site 710685005388 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 710685005389 domain_subunit interface; other site 710685005390 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710685005391 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710685005392 active site 710685005393 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 710685005394 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710685005395 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685005396 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710685005397 aspartate kinase; Reviewed; Region: PRK06635 710685005398 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 710685005399 putative nucleotide binding site [chemical binding]; other site 710685005400 putative catalytic residues [active] 710685005401 putative Mg ion binding site [ion binding]; other site 710685005402 putative aspartate binding site [chemical binding]; other site 710685005403 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 710685005404 putative allosteric regulatory site; other site 710685005405 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 710685005406 putative allosteric regulatory residue; other site 710685005407 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 710685005408 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710685005409 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710685005410 hydroperoxidase II; Provisional; Region: katE; PRK11249 710685005411 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 710685005412 heme binding pocket [chemical binding]; other site 710685005413 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 710685005414 domain interactions; other site 710685005415 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685005416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685005417 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685005418 iron-sulfur cluster [ion binding]; other site 710685005419 [2Fe-2S] cluster binding site [ion binding]; other site 710685005420 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 710685005421 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 710685005422 tetramer interface [polypeptide binding]; other site 710685005423 heme binding pocket [chemical binding]; other site 710685005424 NADPH binding site [chemical binding]; other site 710685005425 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 710685005426 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685005427 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 710685005428 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 710685005429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710685005430 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 710685005431 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710685005432 putative active site [active] 710685005433 putative dimer interface [polypeptide binding]; other site 710685005434 Uncharacterized conserved protein [Function unknown]; Region: COG4301 710685005435 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 710685005436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685005437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685005438 catalytic residue [active] 710685005439 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710685005440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685005441 S-adenosylmethionine binding site [chemical binding]; other site 710685005442 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 710685005443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685005444 S-adenosylmethionine binding site [chemical binding]; other site 710685005445 glycerol kinase; Provisional; Region: glpK; PRK00047 710685005446 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 710685005447 N- and C-terminal domain interface [polypeptide binding]; other site 710685005448 active site 710685005449 MgATP binding site [chemical binding]; other site 710685005450 catalytic site [active] 710685005451 metal binding site [ion binding]; metal-binding site 710685005452 putative homotetramer interface [polypeptide binding]; other site 710685005453 glycerol binding site [chemical binding]; other site 710685005454 homodimer interface [polypeptide binding]; other site 710685005455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685005456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685005457 active site 710685005458 catalytic tetrad [active] 710685005459 Predicted transcriptional regulators [Transcription]; Region: COG1695 710685005460 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710685005461 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710685005462 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685005463 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685005464 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685005465 Predicted membrane protein/domain [Function unknown]; Region: COG1714 710685005466 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 710685005467 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710685005468 Protein of unknown function DUF58; Region: DUF58; pfam01882 710685005469 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685005470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685005471 Walker A motif; other site 710685005472 ATP binding site [chemical binding]; other site 710685005473 Walker B motif; other site 710685005474 arginine finger; other site 710685005475 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 710685005476 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710685005477 Yqey-like protein; Region: YqeY; pfam09424 710685005478 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685005479 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 710685005480 putative methyltransferase; Provisional; Region: PRK14967 710685005481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685005482 S-adenosylmethionine binding site [chemical binding]; other site 710685005483 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 710685005484 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710685005485 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710685005486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685005487 catalytic residue [active] 710685005488 phosphodiesterase YaeI; Provisional; Region: PRK11340 710685005489 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710685005490 putative active site [active] 710685005491 putative metal binding site [ion binding]; other site 710685005492 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710685005493 Transglycosylase; Region: Transgly; pfam00912 710685005494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710685005495 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710685005496 Transcription factor WhiB; Region: Whib; pfam02467 710685005497 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710685005498 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710685005499 DTAP/Switch II; other site 710685005500 Switch I; other site 710685005501 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685005502 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710685005503 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710685005504 P loop; other site 710685005505 Nucleotide binding site [chemical binding]; other site 710685005506 DTAP/Switch II; other site 710685005507 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 710685005508 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 710685005509 homotrimer interaction site [polypeptide binding]; other site 710685005510 putative active site [active] 710685005511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685005512 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685005513 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685005514 ligand binding site [chemical binding]; other site 710685005515 flexible hinge region; other site 710685005516 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710685005517 putative switch regulator; other site 710685005518 non-specific DNA interactions [nucleotide binding]; other site 710685005519 DNA binding site [nucleotide binding] 710685005520 sequence specific DNA binding site [nucleotide binding]; other site 710685005521 putative cAMP binding site [chemical binding]; other site 710685005522 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710685005523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710685005524 minor groove reading motif; other site 710685005525 helix-hairpin-helix signature motif; other site 710685005526 substrate binding pocket [chemical binding]; other site 710685005527 active site 710685005528 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710685005529 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710685005530 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685005531 catalytic residues [active] 710685005532 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710685005533 putative active site [active] 710685005534 putative CoA binding site [chemical binding]; other site 710685005535 nudix motif; other site 710685005536 metal binding site [ion binding]; metal-binding site 710685005537 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710685005538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685005539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685005540 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710685005541 acetyl-CoA synthetase; Provisional; Region: PRK00174 710685005542 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 710685005543 active site 710685005544 CoA binding site [chemical binding]; other site 710685005545 acyl-activating enzyme (AAE) consensus motif; other site 710685005546 AMP binding site [chemical binding]; other site 710685005547 acetate binding site [chemical binding]; other site 710685005548 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710685005549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685005550 motif II; other site 710685005551 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 710685005552 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710685005553 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 710685005554 ATP binding site [chemical binding]; other site 710685005555 Walker A motif; other site 710685005556 hexamer interface [polypeptide binding]; other site 710685005557 Walker B motif; other site 710685005558 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710685005559 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 710685005560 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 710685005561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685005562 ATP binding site [chemical binding]; other site 710685005563 putative Mg++ binding site [ion binding]; other site 710685005564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685005565 ATP-binding site [chemical binding]; other site 710685005566 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 710685005567 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710685005568 DNA-binding site [nucleotide binding]; DNA binding site 710685005569 RNA-binding motif; other site 710685005570 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 710685005571 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 710685005572 active site 710685005573 interdomain interaction site; other site 710685005574 putative metal-binding site [ion binding]; other site 710685005575 nucleotide binding site [chemical binding]; other site 710685005576 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 710685005577 domain I; other site 710685005578 phosphate binding site [ion binding]; other site 710685005579 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 710685005580 domain II; other site 710685005581 domain III; other site 710685005582 nucleotide binding site [chemical binding]; other site 710685005583 DNA binding groove [nucleotide binding] 710685005584 catalytic site [active] 710685005585 domain IV; other site 710685005586 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710685005587 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710685005588 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710685005589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685005590 dimerization interface [polypeptide binding]; other site 710685005591 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685005592 cyclase homology domain; Region: CHD; cd07302 710685005593 nucleotidyl binding site; other site 710685005594 metal binding site [ion binding]; metal-binding site 710685005595 dimer interface [polypeptide binding]; other site 710685005596 DNA polymerase III subunit delta'; Validated; Region: PRK07940 710685005597 DNA polymerase III subunit delta'; Validated; Region: PRK08485 710685005598 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685005599 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 710685005600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685005601 NAD(P) binding site [chemical binding]; other site 710685005602 active site 710685005603 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710685005604 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 710685005605 active site 710685005606 putative substrate binding pocket [chemical binding]; other site 710685005607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685005608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685005609 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 710685005610 Zn binding site [ion binding]; other site 710685005611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685005612 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685005613 acyl-activating enzyme (AAE) consensus motif; other site 710685005614 AMP binding site [chemical binding]; other site 710685005615 active site 710685005616 CoA binding site [chemical binding]; other site 710685005617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685005618 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 710685005619 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710685005620 putative trimer interface [polypeptide binding]; other site 710685005621 putative CoA binding site [chemical binding]; other site 710685005622 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710685005623 putative trimer interface [polypeptide binding]; other site 710685005624 putative CoA binding site [chemical binding]; other site 710685005625 yybP-ykoY leader 710685005626 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 710685005627 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685005628 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685005629 putative OHCU decarboxylase; Provisional; Region: PRK13798 710685005630 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710685005631 dimer interface [polypeptide binding]; other site 710685005632 substrate binding site [chemical binding]; other site 710685005633 metal binding sites [ion binding]; metal-binding site 710685005634 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 710685005635 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 710685005636 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710685005637 putative hydrolase; Region: TIGR03624 710685005638 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710685005639 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710685005640 Ligand Binding Site [chemical binding]; other site 710685005641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685005642 active site 710685005643 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 710685005644 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685005645 putative [Fe4-S4] binding site [ion binding]; other site 710685005646 putative molybdopterin cofactor binding site [chemical binding]; other site 710685005647 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710685005648 putative molybdopterin cofactor binding site; other site 710685005649 Uncharacterized conserved protein [Function unknown]; Region: COG2968 710685005650 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 710685005651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685005652 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685005653 FtsH Extracellular; Region: FtsH_ext; pfam06480 710685005654 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710685005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685005656 Walker A motif; other site 710685005657 ATP binding site [chemical binding]; other site 710685005658 Walker B motif; other site 710685005659 arginine finger; other site 710685005660 Peptidase family M41; Region: Peptidase_M41; pfam01434 710685005661 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 710685005662 homodecamer interface [polypeptide binding]; other site 710685005663 GTP cyclohydrolase I; Provisional; Region: PLN03044 710685005664 active site 710685005665 putative catalytic site residues [active] 710685005666 zinc binding site [ion binding]; other site 710685005667 GTP-CH-I/GFRP interaction surface; other site 710685005668 dihydropteroate synthase; Region: DHPS; TIGR01496 710685005669 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710685005670 substrate binding pocket [chemical binding]; other site 710685005671 dimer interface [polypeptide binding]; other site 710685005672 inhibitor binding site; inhibition site 710685005673 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 710685005674 homooctamer interface [polypeptide binding]; other site 710685005675 active site 710685005676 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 710685005677 catalytic center binding site [active] 710685005678 ATP binding site [chemical binding]; other site 710685005679 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 710685005680 Uncharacterized conserved protein [Function unknown]; Region: COG5495 710685005681 Rossmann-like domain; Region: Rossmann-like; pfam10727 710685005682 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 710685005683 Pantoate-beta-alanine ligase; Region: PanC; cd00560 710685005684 pantoate--beta-alanine ligase; Region: panC; TIGR00018 710685005685 active site 710685005686 ATP-binding site [chemical binding]; other site 710685005687 pantoate-binding site; other site 710685005688 HXXH motif; other site 710685005689 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 710685005690 tetramerization interface [polypeptide binding]; other site 710685005691 active site 710685005692 pantothenate kinase; Reviewed; Region: PRK13318 710685005693 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 710685005694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 710685005695 active site 710685005696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710685005697 dimer interface [polypeptide binding]; other site 710685005698 substrate binding site [chemical binding]; other site 710685005699 catalytic residue [active] 710685005700 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 710685005701 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710685005702 dimer interface [polypeptide binding]; other site 710685005703 putative anticodon binding site; other site 710685005704 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710685005705 motif 1; other site 710685005706 dimer interface [polypeptide binding]; other site 710685005707 active site 710685005708 motif 2; other site 710685005709 motif 3; other site 710685005710 Lsr2; Region: Lsr2; pfam11774 710685005711 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 710685005712 Clp amino terminal domain; Region: Clp_N; pfam02861 710685005713 Clp amino terminal domain; Region: Clp_N; pfam02861 710685005714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685005715 Walker A motif; other site 710685005716 ATP binding site [chemical binding]; other site 710685005717 Walker B motif; other site 710685005718 arginine finger; other site 710685005719 UvrB/uvrC motif; Region: UVR; pfam02151 710685005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685005721 Walker A motif; other site 710685005722 ATP binding site [chemical binding]; other site 710685005723 Walker B motif; other site 710685005724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710685005725 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 710685005726 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 710685005727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685005728 catalytic core [active] 710685005729 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 710685005730 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710685005731 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 710685005732 Lipase (class 2); Region: Lipase_2; pfam01674 710685005733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685005734 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710685005735 catalytic site [active] 710685005736 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710685005737 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710685005738 conserved cys residue [active] 710685005739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685005740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685005741 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685005742 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685005743 cyclase homology domain; Region: CHD; cd07302 710685005744 nucleotidyl binding site; other site 710685005745 metal binding site [ion binding]; metal-binding site 710685005746 dimer interface [polypeptide binding]; other site 710685005747 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710685005748 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710685005749 minor groove reading motif; other site 710685005750 helix-hairpin-helix signature motif; other site 710685005751 substrate binding pocket [chemical binding]; other site 710685005752 active site 710685005753 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710685005754 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 710685005755 active site clefts [active] 710685005756 zinc binding site [ion binding]; other site 710685005757 dimer interface [polypeptide binding]; other site 710685005758 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 710685005759 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710685005760 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 710685005761 DNA repair protein RadA; Provisional; Region: PRK11823 710685005762 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 710685005763 Walker A motif/ATP binding site; other site 710685005764 ATP binding site [chemical binding]; other site 710685005765 Walker B motif; other site 710685005766 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710685005767 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 710685005768 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 710685005769 homotrimer interaction site [polypeptide binding]; other site 710685005770 zinc binding site [ion binding]; other site 710685005771 CDP-binding sites; other site 710685005772 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710685005773 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710685005774 active site 710685005775 HIGH motif; other site 710685005776 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710685005777 KMSKS motif; other site 710685005778 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 710685005779 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710685005780 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710685005781 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710685005782 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710685005783 active site 710685005784 catalytic triad [active] 710685005785 oxyanion hole [active] 710685005786 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710685005787 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 710685005788 transmembrane helices; other site 710685005789 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710685005790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685005791 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 710685005792 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 710685005793 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 710685005794 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 710685005795 putative active site [active] 710685005796 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 710685005797 putative FMN binding site [chemical binding]; other site 710685005798 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710685005799 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710685005800 active site residue [active] 710685005801 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710685005802 active site residue [active] 710685005803 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710685005804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 710685005805 putative PBP binding regions; other site 710685005806 ABC-ATPase subunit interface; other site 710685005807 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710685005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685005809 Walker A/P-loop; other site 710685005810 ATP binding site [chemical binding]; other site 710685005811 Q-loop/lid; other site 710685005812 ABC transporter signature motif; other site 710685005813 Walker B; other site 710685005814 D-loop; other site 710685005815 H-loop/switch region; other site 710685005816 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710685005817 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 710685005818 intersubunit interface [polypeptide binding]; other site 710685005819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710685005820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710685005821 DNA binding site [nucleotide binding] 710685005822 domain linker motif; other site 710685005823 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 710685005824 putative dimerization interface [polypeptide binding]; other site 710685005825 putative ligand binding site [chemical binding]; other site 710685005826 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 710685005827 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 710685005828 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 710685005829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685005830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685005831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005832 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685005833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005834 active site 710685005835 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005837 active site 710685005838 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710685005839 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710685005840 FAD binding pocket [chemical binding]; other site 710685005841 FAD binding motif [chemical binding]; other site 710685005842 phosphate binding motif [ion binding]; other site 710685005843 beta-alpha-beta structure motif; other site 710685005844 NAD(p) ribose binding residues [chemical binding]; other site 710685005845 NAD binding pocket [chemical binding]; other site 710685005846 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710685005847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685005848 catalytic loop [active] 710685005849 iron binding site [ion binding]; other site 710685005850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005851 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 710685005852 Flavin binding site [chemical binding]; other site 710685005853 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710685005854 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710685005855 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710685005856 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710685005857 active site 710685005858 Fe binding site [ion binding]; other site 710685005859 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710685005860 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710685005861 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685005862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685005863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710685005864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685005865 LysR substrate binding domain; Region: LysR_substrate; pfam03466 710685005866 dimerization interface [polypeptide binding]; other site 710685005867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685005868 metabolite-proton symporter; Region: 2A0106; TIGR00883 710685005869 putative substrate translocation pore; other site 710685005870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685005871 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 710685005872 NAD(P) binding site [chemical binding]; other site 710685005873 active site 710685005874 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 710685005875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685005876 acyl-activating enzyme (AAE) consensus motif; other site 710685005877 AMP binding site [chemical binding]; other site 710685005878 active site 710685005879 CoA binding site [chemical binding]; other site 710685005880 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685005881 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685005882 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685005883 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685005884 active site 710685005885 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710685005886 aspartate aminotransferase; Provisional; Region: PRK05764 710685005887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685005888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685005889 homodimer interface [polypeptide binding]; other site 710685005890 catalytic residue [active] 710685005891 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 710685005892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685005893 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710685005894 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685005895 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 710685005896 active site 710685005897 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685005898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005900 active site 710685005901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005903 active site 710685005904 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710685005905 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685005906 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710685005907 acyl-activating enzyme (AAE) consensus motif; other site 710685005908 acyl-activating enzyme (AAE) consensus motif; other site 710685005909 putative AMP binding site [chemical binding]; other site 710685005910 putative active site [active] 710685005911 putative CoA binding site [chemical binding]; other site 710685005912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005914 active site 710685005915 short chain dehydrogenase; Provisional; Region: PRK07831 710685005916 classical (c) SDRs; Region: SDR_c; cd05233 710685005917 NAD(P) binding site [chemical binding]; other site 710685005918 active site 710685005919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685005920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685005921 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 710685005922 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710685005923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685005924 dimer interface [polypeptide binding]; other site 710685005925 active site 710685005926 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685005927 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685005928 NAD binding site [chemical binding]; other site 710685005929 catalytic Zn binding site [ion binding]; other site 710685005930 substrate binding site [chemical binding]; other site 710685005931 structural Zn binding site [ion binding]; other site 710685005932 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685005933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685005934 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710685005935 Transport protein; Region: actII; TIGR00833 710685005936 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 710685005937 Condensation domain; Region: Condensation; pfam00668 710685005938 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 710685005939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685005940 ATP binding site [chemical binding]; other site 710685005941 Mg2+ binding site [ion binding]; other site 710685005942 G-X-G motif; other site 710685005943 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710685005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685005945 active site 710685005946 phosphorylation site [posttranslational modification] 710685005947 intermolecular recognition site; other site 710685005948 dimerization interface [polypeptide binding]; other site 710685005949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685005950 putative DNA binding site [nucleotide binding]; other site 710685005951 putative Zn2+ binding site [ion binding]; other site 710685005952 Nitronate monooxygenase; Region: NMO; pfam03060 710685005953 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685005954 FMN binding site [chemical binding]; other site 710685005955 substrate binding site [chemical binding]; other site 710685005956 putative catalytic residue [active] 710685005957 Coenzyme A transferase; Region: CoA_trans; cl17247 710685005958 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710685005959 enoyl-CoA hydratase; Provisional; Region: PRK06495 710685005960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685005961 substrate binding site [chemical binding]; other site 710685005962 oxyanion hole (OAH) forming residues; other site 710685005963 trimer interface [polypeptide binding]; other site 710685005964 short chain dehydrogenase; Provisional; Region: PRK07856 710685005965 classical (c) SDRs; Region: SDR_c; cd05233 710685005966 NAD(P) binding site [chemical binding]; other site 710685005967 active site 710685005968 short chain dehydrogenase; Provisional; Region: PRK07791 710685005969 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 710685005970 homodimer interface [polypeptide binding]; other site 710685005971 NAD binding site [chemical binding]; other site 710685005972 active site 710685005973 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685005974 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685005975 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 710685005976 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685005977 dimer interface [polypeptide binding]; other site 710685005978 active site 710685005979 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685005980 Cytochrome P450; Region: p450; cl12078 710685005981 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 710685005982 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685005983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685005985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685005986 active site 710685005987 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685005988 active site 710685005989 catalytic site [active] 710685005990 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685005991 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685005992 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 710685005993 putative active site [active] 710685005994 putative catalytic site [active] 710685005995 lipid-transfer protein; Provisional; Region: PRK07855 710685005996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685005997 active site 710685005998 enoyl-CoA hydratase; Region: PLN02864 710685005999 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685006000 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710685006001 dimer interaction site [polypeptide binding]; other site 710685006002 substrate-binding tunnel; other site 710685006003 active site 710685006004 catalytic site [active] 710685006005 substrate binding site [chemical binding]; other site 710685006006 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 710685006007 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685006008 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 710685006009 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710685006010 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710685006011 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710685006012 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710685006013 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710685006014 active site 710685006015 catalytic residues [active] 710685006016 metal binding site [ion binding]; metal-binding site 710685006017 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710685006018 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 710685006019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685006020 ATP binding site [chemical binding]; other site 710685006021 putative Mg++ binding site [ion binding]; other site 710685006022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685006023 nucleotide binding region [chemical binding]; other site 710685006024 ATP-binding site [chemical binding]; other site 710685006025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685006026 active site 710685006027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685006028 putative DNA binding site [nucleotide binding]; other site 710685006029 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685006030 putative Zn2+ binding site [ion binding]; other site 710685006031 short chain dehydrogenase; Provisional; Region: PRK07890 710685006032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006033 NAD(P) binding site [chemical binding]; other site 710685006034 active site 710685006035 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 710685006036 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685006037 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685006038 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710685006039 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710685006040 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710685006041 trimer interface [polypeptide binding]; other site 710685006042 putative metal binding site [ion binding]; other site 710685006043 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 710685006044 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 710685006045 MOSC domain; Region: MOSC; pfam03473 710685006046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685006047 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685006048 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685006049 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 710685006050 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685006051 active site 710685006052 lipid-transfer protein; Provisional; Region: PRK07937 710685006053 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685006054 active site 710685006055 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685006056 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685006057 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685006058 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685006059 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685006060 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710685006061 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 710685006062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006063 Cytochrome P450; Region: p450; cl12078 710685006064 enoyl-CoA hydratase; Provisional; Region: PRK07799 710685006065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006066 substrate binding site [chemical binding]; other site 710685006067 oxyanion hole (OAH) forming residues; other site 710685006068 trimer interface [polypeptide binding]; other site 710685006069 acyl-CoA synthetase; Validated; Region: PRK07798 710685006070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006071 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710685006072 acyl-activating enzyme (AAE) consensus motif; other site 710685006073 acyl-activating enzyme (AAE) consensus motif; other site 710685006074 putative AMP binding site [chemical binding]; other site 710685006075 putative active site [active] 710685006076 putative CoA binding site [chemical binding]; other site 710685006077 Nitronate monooxygenase; Region: NMO; pfam03060 710685006078 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685006079 FMN binding site [chemical binding]; other site 710685006080 substrate binding site [chemical binding]; other site 710685006081 putative catalytic residue [active] 710685006082 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710685006083 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710685006084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685006085 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 710685006086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006087 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710685006088 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710685006089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685006090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006091 NAD(P) binding site [chemical binding]; other site 710685006092 active site 710685006093 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710685006094 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 710685006095 active site 710685006096 FMN binding site [chemical binding]; other site 710685006097 substrate binding site [chemical binding]; other site 710685006098 putative catalytic residue [active] 710685006099 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685006100 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685006101 active site 710685006102 TDP-binding site; other site 710685006103 acceptor substrate-binding pocket; other site 710685006104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006106 acyl-CoA synthetase; Validated; Region: PRK07867 710685006107 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 710685006108 acyl-activating enzyme (AAE) consensus motif; other site 710685006109 putative AMP binding site [chemical binding]; other site 710685006110 putative active site [active] 710685006111 putative CoA binding site [chemical binding]; other site 710685006112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685006113 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685006114 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685006115 active site 710685006116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685006117 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710685006118 FAD binding site [chemical binding]; other site 710685006119 substrate binding site [chemical binding]; other site 710685006120 catalytic base [active] 710685006121 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685006122 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685006123 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 710685006124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006125 NAD(P) binding site [chemical binding]; other site 710685006126 active site 710685006127 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685006128 Permease; Region: Permease; pfam02405 710685006129 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685006130 Permease; Region: Permease; pfam02405 710685006131 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006132 mce related protein; Region: MCE; pfam02470 710685006133 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685006134 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006135 mce related protein; Region: MCE; pfam02470 710685006136 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006137 mce related protein; Region: MCE; pfam02470 710685006138 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006139 mce related protein; Region: MCE; pfam02470 710685006140 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006141 mce related protein; Region: MCE; pfam02470 710685006142 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006143 mce related protein; Region: MCE; pfam02470 710685006144 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 710685006145 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 710685006146 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 710685006147 active site 710685006148 homotetramer interface [polypeptide binding]; other site 710685006149 enoyl-CoA hydratase; Provisional; Region: PRK08290 710685006150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006151 substrate binding site [chemical binding]; other site 710685006152 oxyanion hole (OAH) forming residues; other site 710685006153 trimer interface [polypeptide binding]; other site 710685006154 classical (c) SDRs; Region: SDR_c; cd05233 710685006155 NAD(P) binding site [chemical binding]; other site 710685006156 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 710685006157 active site 710685006158 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685006159 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685006160 active site 710685006161 GXWXG protein; Region: GXWXG; pfam14231 710685006162 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 710685006163 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710685006164 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710685006165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685006166 catalytic loop [active] 710685006167 iron binding site [ion binding]; other site 710685006168 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710685006169 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710685006170 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 710685006171 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 710685006172 putative hydrophobic ligand binding site [chemical binding]; other site 710685006173 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710685006174 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710685006175 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710685006176 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 710685006177 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 710685006178 XdhC Rossmann domain; Region: XdhC_C; pfam13478 710685006179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006180 Cytochrome P450; Region: p450; cl12078 710685006181 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 710685006182 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710685006183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685006184 D-galactonate transporter; Region: 2A0114; TIGR00893 710685006185 putative substrate translocation pore; other site 710685006186 Prostaglandin dehydrogenases; Region: PGDH; cd05288 710685006187 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 710685006188 NAD(P) binding site [chemical binding]; other site 710685006189 substrate binding site [chemical binding]; other site 710685006190 dimer interface [polypeptide binding]; other site 710685006191 Cutinase; Region: Cutinase; pfam01083 710685006192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685006194 NAD(P) binding site [chemical binding]; other site 710685006195 active site 710685006196 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006197 Cytochrome P450; Region: p450; cl12078 710685006198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006200 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 710685006201 Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345 710685006202 Cupin domain; Region: Cupin_2; cl17218 710685006203 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710685006204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006205 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685006206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006207 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685006208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 710685006209 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 710685006210 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 710685006211 Uncharacterized conserved protein [Function unknown]; Region: COG2006 710685006212 Domain of unknown function (DUF362); Region: DUF362; pfam04015 710685006213 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 710685006214 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 710685006215 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710685006216 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 710685006217 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 710685006218 glutamine binding [chemical binding]; other site 710685006219 catalytic triad [active] 710685006220 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710685006221 Ligand Binding Site [chemical binding]; other site 710685006222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 710685006223 AIR carboxylase; Region: AIRC; cl00310 710685006224 hypothetical protein; Provisional; Region: PRK04194 710685006225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006226 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685006227 acyl-activating enzyme (AAE) consensus motif; other site 710685006228 AMP binding site [chemical binding]; other site 710685006229 active site 710685006230 CoA binding site [chemical binding]; other site 710685006231 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 710685006232 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 710685006233 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 710685006234 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 710685006235 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 710685006236 tetramer interface [polypeptide binding]; other site 710685006237 active site 710685006238 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 710685006239 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 710685006240 homodimer interface [polypeptide binding]; other site 710685006241 substrate-cofactor binding pocket; other site 710685006242 catalytic residue [active] 710685006243 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710685006244 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685006245 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 710685006246 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 710685006247 hypothetical protein; Provisional; Region: PRK07206 710685006248 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 710685006249 HNH endonuclease; Region: HNH_3; pfam13392 710685006250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685006251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685006252 active site 710685006253 phosphorylation site [posttranslational modification] 710685006254 intermolecular recognition site; other site 710685006255 dimerization interface [polypeptide binding]; other site 710685006256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685006257 DNA binding site [nucleotide binding] 710685006258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685006259 dimerization interface [polypeptide binding]; other site 710685006260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685006261 dimer interface [polypeptide binding]; other site 710685006262 phosphorylation site [posttranslational modification] 710685006263 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685006264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685006265 ATP binding site [chemical binding]; other site 710685006266 Mg2+ binding site [ion binding]; other site 710685006267 G-X-G motif; other site 710685006268 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 710685006269 nucleotide binding site/active site [active] 710685006270 HIT family signature motif; other site 710685006271 catalytic residue [active] 710685006272 classical (c) SDRs; Region: SDR_c; cd05233 710685006273 NAD(P) binding site [chemical binding]; other site 710685006274 active site 710685006275 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685006276 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685006277 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685006278 NAD binding site [chemical binding]; other site 710685006279 catalytic Zn binding site [ion binding]; other site 710685006280 substrate binding site [chemical binding]; other site 710685006281 structural Zn binding site [ion binding]; other site 710685006282 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685006283 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685006284 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006285 Cytochrome P450; Region: p450; cl12078 710685006286 short chain dehydrogenase; Provisional; Region: PRK07775 710685006287 classical (c) SDRs; Region: SDR_c; cd05233 710685006288 NAD(P) binding site [chemical binding]; other site 710685006289 active site 710685006290 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006291 Cytochrome P450; Region: p450; cl12078 710685006292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006293 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710685006294 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685006295 NAD binding site [chemical binding]; other site 710685006296 catalytic residues [active] 710685006297 short chain dehydrogenase; Provisional; Region: PRK07774 710685006298 classical (c) SDRs; Region: SDR_c; cd05233 710685006299 NAD(P) binding site [chemical binding]; other site 710685006300 active site 710685006301 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710685006302 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685006303 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710685006304 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006305 Cytochrome P450; Region: p450; cl12078 710685006306 Predicted membrane protein [Function unknown]; Region: COG4270 710685006307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006310 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710685006311 DNA-binding interface [nucleotide binding]; DNA binding site 710685006312 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006313 Cytochrome P450; Region: p450; cl12078 710685006314 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710685006315 Amidinotransferase; Region: Amidinotransf; cl12043 710685006316 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 710685006317 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 710685006318 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 710685006319 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 710685006320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710685006321 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006323 NAD(P) binding site [chemical binding]; other site 710685006324 active site 710685006325 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685006326 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 710685006327 adenylosuccinate lyase; Region: purB; TIGR00928 710685006328 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 710685006329 tetramer interface [polypeptide binding]; other site 710685006330 active site 710685006331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006332 Cytochrome P450; Region: p450; cl12078 710685006333 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 710685006334 gating phenylalanine in ion channel; other site 710685006335 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710685006336 trehalose synthase; Region: treS_nterm; TIGR02456 710685006337 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 710685006338 active site 710685006339 catalytic site [active] 710685006340 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 710685006341 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 710685006342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006344 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710685006345 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710685006346 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710685006347 active site 710685006348 catalytic site [active] 710685006349 enoyl-CoA hydratase; Provisional; Region: PRK08260 710685006350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006351 substrate binding site [chemical binding]; other site 710685006352 oxyanion hole (OAH) forming residues; other site 710685006353 trimer interface [polypeptide binding]; other site 710685006354 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 710685006355 Isochorismatase family; Region: Isochorismatase; pfam00857 710685006356 catalytic triad [active] 710685006357 metal binding site [ion binding]; metal-binding site 710685006358 conserved cis-peptide bond; other site 710685006359 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 710685006360 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685006361 NAD binding site [chemical binding]; other site 710685006362 catalytic Zn binding site [ion binding]; other site 710685006363 structural Zn binding site [ion binding]; other site 710685006364 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685006365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685006366 active site 710685006367 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 710685006368 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685006369 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 710685006370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685006371 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685006372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685006373 S-adenosylmethionine binding site [chemical binding]; other site 710685006374 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 710685006375 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710685006376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006379 Cytochrome P450; Region: p450; cl12078 710685006380 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006381 Cytochrome P450; Region: p450; cl12078 710685006382 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685006383 CoenzymeA binding site [chemical binding]; other site 710685006384 subunit interaction site [polypeptide binding]; other site 710685006385 PHB binding site; other site 710685006386 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710685006387 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 710685006388 methionine sulfoxide reductase A; Provisional; Region: PRK14054 710685006389 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685006390 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710685006391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006392 NAD(P) binding site [chemical binding]; other site 710685006393 active site 710685006394 AAA ATPase domain; Region: AAA_16; pfam13191 710685006395 Predicted ATPase [General function prediction only]; Region: COG3899 710685006396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685006397 DNA binding residues [nucleotide binding] 710685006398 dimerization interface [polypeptide binding]; other site 710685006399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685006400 classical (c) SDRs; Region: SDR_c; cd05233 710685006401 NAD(P) binding site [chemical binding]; other site 710685006402 active site 710685006403 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710685006404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685006405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685006406 DNA binding residues [nucleotide binding] 710685006407 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685006408 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685006409 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685006410 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685006411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006412 substrate binding site [chemical binding]; other site 710685006413 oxyanion hole (OAH) forming residues; other site 710685006414 trimer interface [polypeptide binding]; other site 710685006415 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685006416 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685006417 phosphopeptide binding site; other site 710685006418 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685006419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685006420 active site 710685006421 ATP binding site [chemical binding]; other site 710685006422 substrate binding site [chemical binding]; other site 710685006423 activation loop (A-loop); other site 710685006424 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685006425 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685006426 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710685006427 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685006428 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685006429 hydrophobic ligand binding site; other site 710685006430 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710685006431 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710685006432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710685006433 minor groove reading motif; other site 710685006434 helix-hairpin-helix signature motif; other site 710685006435 active site 710685006436 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 710685006437 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710685006438 dimerization interface [polypeptide binding]; other site 710685006439 DPS ferroxidase diiron center [ion binding]; other site 710685006440 ion pore; other site 710685006441 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 710685006442 amphipathic channel; other site 710685006443 Asn-Pro-Ala signature motifs; other site 710685006444 Cupin; Region: Cupin_1; smart00835 710685006445 Cupin; Region: Cupin_1; smart00835 710685006446 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685006447 CoenzymeA binding site [chemical binding]; other site 710685006448 subunit interaction site [polypeptide binding]; other site 710685006449 PHB binding site; other site 710685006450 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710685006451 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685006452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685006453 motif II; other site 710685006454 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710685006455 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710685006456 active site 710685006457 dimer interface [polypeptide binding]; other site 710685006458 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710685006459 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710685006460 active site 710685006461 FMN binding site [chemical binding]; other site 710685006462 substrate binding site [chemical binding]; other site 710685006463 3Fe-4S cluster binding site [ion binding]; other site 710685006464 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710685006465 domain interface; other site 710685006466 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710685006467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006468 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 710685006469 ATP binding site [chemical binding]; other site 710685006470 active site 710685006471 substrate binding site [chemical binding]; other site 710685006472 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 710685006473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685006474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006476 WHG domain; Region: WHG; pfam13305 710685006477 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 710685006478 catalytic residues [active] 710685006479 dimer interface [polypeptide binding]; other site 710685006480 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 710685006481 Predicted deacetylase [General function prediction only]; Region: COG3233 710685006482 putative active site [active] 710685006483 putative Zn binding site [ion binding]; other site 710685006484 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685006485 FAD binding domain; Region: FAD_binding_2; pfam00890 710685006486 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710685006487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685006488 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685006489 MULE transposase domain; Region: MULE; pfam10551 710685006490 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 710685006491 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 710685006492 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 710685006493 putative active site [active] 710685006494 catalytic triad [active] 710685006495 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685006496 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685006497 Integrase core domain; Region: rve; pfam00665 710685006498 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 710685006499 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 710685006500 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 710685006501 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 710685006502 active site 710685006503 metal binding site [ion binding]; metal-binding site 710685006504 yybP-ykoY leader 710685006505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 710685006506 putative Zn2+ binding site [ion binding]; other site 710685006507 putative DNA binding site [nucleotide binding]; other site 710685006508 yybP-ykoY leader 710685006509 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 710685006510 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685006511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685006512 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 710685006513 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 710685006514 dimerization interface [polypeptide binding]; other site 710685006515 ATP binding site [chemical binding]; other site 710685006516 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 710685006517 dimerization interface [polypeptide binding]; other site 710685006518 ATP binding site [chemical binding]; other site 710685006519 Predicted membrane protein [Function unknown]; Region: COG4425 710685006520 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710685006521 CAAX protease self-immunity; Region: Abi; pfam02517 710685006522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685006523 classical (c) SDRs; Region: SDR_c; cd05233 710685006524 NAD(P) binding site [chemical binding]; other site 710685006525 active site 710685006526 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006527 mce related protein; Region: MCE; pfam02470 710685006528 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685006529 amidophosphoribosyltransferase; Provisional; Region: PRK07847 710685006530 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 710685006531 active site 710685006532 tetramer interface [polypeptide binding]; other site 710685006533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685006534 active site 710685006535 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 710685006536 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710685006537 putative NAD(P) binding site [chemical binding]; other site 710685006538 putative active site [active] 710685006539 Cupin domain; Region: Cupin_2; pfam07883 710685006540 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 710685006541 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 710685006542 dimerization interface [polypeptide binding]; other site 710685006543 putative ATP binding site [chemical binding]; other site 710685006544 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 710685006545 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 710685006546 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 710685006547 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710685006548 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710685006549 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 710685006550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685006551 catalytic residue [active] 710685006552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685006553 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685006554 ligand binding site [chemical binding]; other site 710685006555 flexible hinge region; other site 710685006556 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685006557 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685006558 ligand binding site [chemical binding]; other site 710685006559 flexible hinge region; other site 710685006560 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 710685006561 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 710685006562 putative active site [active] 710685006563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685006564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685006565 Walker A/P-loop; other site 710685006566 ATP binding site [chemical binding]; other site 710685006567 Q-loop/lid; other site 710685006568 ABC transporter signature motif; other site 710685006569 Walker B; other site 710685006570 D-loop; other site 710685006571 H-loop/switch region; other site 710685006572 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685006573 phosphopeptide binding site; other site 710685006574 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685006575 cyclase homology domain; Region: CHD; cd07302 710685006576 nucleotidyl binding site; other site 710685006577 metal binding site [ion binding]; metal-binding site 710685006578 dimer interface [polypeptide binding]; other site 710685006579 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 710685006580 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685006581 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 710685006582 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685006583 active site 710685006584 DNA binding site [nucleotide binding] 710685006585 Int/Topo IB signature motif; other site 710685006586 Resolvase, N terminal domain; Region: Resolvase; pfam00239 710685006587 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710685006588 catalytic residues [active] 710685006589 Recombinase; Region: Recombinase; pfam07508 710685006590 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710685006591 nucleotide binding site [chemical binding]; other site 710685006592 AAA domain; Region: AAA_25; pfam13481 710685006593 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 710685006594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685006595 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685006596 substrate binding pocket [chemical binding]; other site 710685006597 membrane-bound complex binding site; other site 710685006598 hinge residues; other site 710685006599 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710685006600 heme-binding site [chemical binding]; other site 710685006601 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 710685006602 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710685006603 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710685006604 active site residue [active] 710685006605 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710685006606 active site residue [active] 710685006607 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 710685006608 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710685006609 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685006610 catalytic residues [active] 710685006611 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710685006612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685006613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685006614 DNA binding site [nucleotide binding] 710685006615 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 710685006616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710685006617 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710685006618 PBP superfamily domain; Region: PBP_like_2; cl17296 710685006619 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 710685006620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685006621 dimer interface [polypeptide binding]; other site 710685006622 conserved gate region; other site 710685006623 putative PBP binding loops; other site 710685006624 ABC-ATPase subunit interface; other site 710685006625 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 710685006626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685006627 dimer interface [polypeptide binding]; other site 710685006628 conserved gate region; other site 710685006629 putative PBP binding loops; other site 710685006630 ABC-ATPase subunit interface; other site 710685006631 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 710685006632 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 710685006633 Walker A/P-loop; other site 710685006634 ATP binding site [chemical binding]; other site 710685006635 Q-loop/lid; other site 710685006636 ABC transporter signature motif; other site 710685006637 Walker B; other site 710685006638 D-loop; other site 710685006639 H-loop/switch region; other site 710685006640 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710685006641 PhoU domain; Region: PhoU; pfam01895 710685006642 PhoU domain; Region: PhoU; pfam01895 710685006643 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710685006644 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710685006645 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 710685006646 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 710685006647 FMN binding site [chemical binding]; other site 710685006648 active site 710685006649 catalytic residues [active] 710685006650 substrate binding site [chemical binding]; other site 710685006651 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 710685006652 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 710685006653 homodimer interface [polypeptide binding]; other site 710685006654 putative substrate binding pocket [chemical binding]; other site 710685006655 diiron center [ion binding]; other site 710685006656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 710685006658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685006659 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685006660 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685006661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006662 short chain dehydrogenase; Provisional; Region: PRK07832 710685006663 NAD(P) binding site [chemical binding]; other site 710685006664 active site 710685006665 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685006666 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685006667 NAD(P) binding site [chemical binding]; other site 710685006668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685006669 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685006670 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710685006671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006673 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710685006674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006675 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685006676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685006677 active site 710685006678 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 710685006679 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685006680 putative NAD(P) binding site [chemical binding]; other site 710685006681 active site 710685006682 putative substrate binding site [chemical binding]; other site 710685006683 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710685006684 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685006685 Permease; Region: Permease; pfam02405 710685006686 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685006687 Permease; Region: Permease; pfam02405 710685006688 mce related protein; Region: MCE; pfam02470 710685006689 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685006690 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006691 mce related protein; Region: MCE; pfam02470 710685006692 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685006693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006694 mce related protein; Region: MCE; pfam02470 710685006695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006696 mce related protein; Region: MCE; pfam02470 710685006697 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006698 mce related protein; Region: MCE; pfam02470 710685006699 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685006700 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685006701 mce related protein; Region: MCE; pfam02470 710685006702 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685006703 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685006704 putative hydrophobic ligand binding site [chemical binding]; other site 710685006705 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685006706 putative hydrophobic ligand binding site [chemical binding]; other site 710685006707 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685006708 putative hydrophobic ligand binding site [chemical binding]; other site 710685006709 Cation efflux family; Region: Cation_efflux; pfam01545 710685006710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685006711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685006712 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685006713 putative hydrophobic ligand binding site [chemical binding]; other site 710685006714 aminotransferase; Validated; Region: PRK07777 710685006715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685006716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685006717 homodimer interface [polypeptide binding]; other site 710685006718 catalytic residue [active] 710685006719 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710685006720 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 710685006721 FMN binding site [chemical binding]; other site 710685006722 active site 710685006723 substrate binding site [chemical binding]; other site 710685006724 catalytic residue [active] 710685006725 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 710685006726 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685006727 dimer interface [polypeptide binding]; other site 710685006728 active site 710685006729 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 710685006730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006731 substrate binding site [chemical binding]; other site 710685006732 oxyanion hole (OAH) forming residues; other site 710685006733 trimer interface [polypeptide binding]; other site 710685006734 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710685006735 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710685006736 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685006737 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006738 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006739 acyl-activating enzyme (AAE) consensus motif; other site 710685006740 AMP binding site [chemical binding]; other site 710685006741 active site 710685006742 acyl-activating enzyme (AAE) consensus motif; other site 710685006743 CoA binding site [chemical binding]; other site 710685006744 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710685006745 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710685006746 Amidase; Region: Amidase; cl11426 710685006747 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685006748 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685006749 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710685006750 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710685006751 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710685006752 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 710685006753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685006754 ATP binding site [chemical binding]; other site 710685006755 putative Mg++ binding site [ion binding]; other site 710685006756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685006757 nucleotide binding region [chemical binding]; other site 710685006758 ATP-binding site [chemical binding]; other site 710685006759 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710685006760 WYL domain; Region: WYL; pfam13280 710685006761 Transposase (partial DDE domain); Region: Transposase_1; pfam01359 710685006762 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 710685006763 trimer interface [polypeptide binding]; other site 710685006764 dimer interface [polypeptide binding]; other site 710685006765 putative active site [active] 710685006766 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710685006767 MPT binding site; other site 710685006768 trimer interface [polypeptide binding]; other site 710685006769 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 710685006770 MoaD interaction [polypeptide binding]; other site 710685006771 active site residues [active] 710685006772 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710685006773 Ubiquitin-like proteins; Region: UBQ; cl00155 710685006774 charged pocket; other site 710685006775 hydrophobic patch; other site 710685006776 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 710685006777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685006778 FeS/SAM binding site; other site 710685006779 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 710685006780 hypothetical protein; Provisional; Region: PRK11770 710685006781 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710685006782 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710685006783 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710685006784 DNA-binding site [nucleotide binding]; DNA binding site 710685006785 RNA-binding motif; other site 710685006786 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 710685006787 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 710685006788 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 710685006789 putative dimer interface [polypeptide binding]; other site 710685006790 N-terminal domain interface [polypeptide binding]; other site 710685006791 putative substrate binding pocket (H-site) [chemical binding]; other site 710685006792 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 710685006793 H+ Antiporter protein; Region: 2A0121; TIGR00900 710685006794 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 710685006795 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685006796 hydrophobic ligand binding site; other site 710685006797 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 710685006798 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710685006799 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710685006800 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 710685006801 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 710685006802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685006803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685006804 catalytic residue [active] 710685006805 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710685006806 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710685006807 active site 710685006808 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710685006809 Ferredoxin [Energy production and conversion]; Region: COG1146 710685006810 4Fe-4S binding domain; Region: Fer4; pfam00037 710685006811 ferredoxin-NADP+ reductase; Region: PLN02852 710685006812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006813 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710685006814 putative dimer interface [polypeptide binding]; other site 710685006815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685006816 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710685006817 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 710685006818 active site 710685006819 catalytic residues [active] 710685006820 TIGR03086 family protein; Region: TIGR03086 710685006821 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685006822 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710685006823 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 710685006824 dimer interface [polypeptide binding]; other site 710685006825 active site 710685006826 citrylCoA binding site [chemical binding]; other site 710685006827 oxalacetate/citrate binding site [chemical binding]; other site 710685006828 coenzyme A binding site [chemical binding]; other site 710685006829 catalytic triad [active] 710685006830 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 710685006831 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710685006832 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 710685006833 enterobactin exporter EntS; Provisional; Region: PRK10489 710685006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 710685006835 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685006836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006837 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 710685006838 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710685006839 dimer interface [polypeptide binding]; other site 710685006840 active site 710685006841 citrylCoA binding site [chemical binding]; other site 710685006842 NADH binding [chemical binding]; other site 710685006843 cationic pore residues; other site 710685006844 oxalacetate/citrate binding site [chemical binding]; other site 710685006845 coenzyme A binding site [chemical binding]; other site 710685006846 catalytic triad [active] 710685006847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685006848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685006849 putative substrate translocation pore; other site 710685006850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685006851 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710685006852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685006853 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 710685006854 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710685006855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685006856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685006857 dimerization interface [polypeptide binding]; other site 710685006858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685006859 dimer interface [polypeptide binding]; other site 710685006860 phosphorylation site [posttranslational modification] 710685006861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685006862 ATP binding site [chemical binding]; other site 710685006863 Mg2+ binding site [ion binding]; other site 710685006864 G-X-G motif; other site 710685006865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685006866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685006867 active site 710685006868 phosphorylation site [posttranslational modification] 710685006869 intermolecular recognition site; other site 710685006870 dimerization interface [polypeptide binding]; other site 710685006871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685006872 DNA binding site [nucleotide binding] 710685006873 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 710685006874 PLD-like domain; Region: PLDc_2; pfam13091 710685006875 putative active site [active] 710685006876 putative catalytic site [active] 710685006877 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 710685006878 PLD-like domain; Region: PLDc_2; pfam13091 710685006879 putative active site [active] 710685006880 putative catalytic site [active] 710685006881 Chromate transporter; Region: Chromate_transp; pfam02417 710685006882 Chromate transporter; Region: Chromate_transp; pfam02417 710685006883 Ion transport protein; Region: Ion_trans; pfam00520 710685006884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710685006885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685006886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685006887 Walker A/P-loop; other site 710685006888 ATP binding site [chemical binding]; other site 710685006889 Q-loop/lid; other site 710685006890 ABC transporter signature motif; other site 710685006891 Walker B; other site 710685006892 D-loop; other site 710685006893 H-loop/switch region; other site 710685006894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685006895 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 710685006896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685006897 Walker A/P-loop; other site 710685006898 ATP binding site [chemical binding]; other site 710685006899 Q-loop/lid; other site 710685006900 ABC transporter signature motif; other site 710685006901 Walker B; other site 710685006902 D-loop; other site 710685006903 H-loop/switch region; other site 710685006904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685006905 Epoxide hydrolase N terminus; Region: EHN; pfam06441 710685006906 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685006907 AMP-binding domain protein; Validated; Region: PRK08315 710685006908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006909 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710685006910 acyl-activating enzyme (AAE) consensus motif; other site 710685006911 acyl-activating enzyme (AAE) consensus motif; other site 710685006912 putative AMP binding site [chemical binding]; other site 710685006913 putative active site [active] 710685006914 putative CoA binding site [chemical binding]; other site 710685006915 FAD binding domain; Region: FAD_binding_3; pfam01494 710685006916 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006918 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 710685006919 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685006920 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685006921 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685006922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685006923 substrate binding site [chemical binding]; other site 710685006924 oxyanion hole (OAH) forming residues; other site 710685006925 trimer interface [polypeptide binding]; other site 710685006926 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710685006927 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710685006928 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685006929 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685006930 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 710685006931 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710685006932 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685006933 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710685006934 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710685006935 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685006936 hydrophobic ligand binding site; other site 710685006937 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 710685006938 dimer interface [polypeptide binding]; other site 710685006939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685006940 ligand binding site [chemical binding]; other site 710685006941 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 710685006942 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006943 Cytochrome P450; Region: p450; cl12078 710685006944 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685006945 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685006946 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685006947 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685006948 Cytochrome P450; Region: p450; cl12078 710685006949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685006950 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710685006951 Walker A motif; other site 710685006952 ATP binding site [chemical binding]; other site 710685006953 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710685006954 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710685006955 metal ion-dependent adhesion site (MIDAS); other site 710685006956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685006959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685006960 short chain dehydrogenase; Provisional; Region: PRK07814 710685006961 classical (c) SDRs; Region: SDR_c; cd05233 710685006962 NAD(P) binding site [chemical binding]; other site 710685006963 active site 710685006964 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685006965 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685006967 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710685006968 NAD(P) binding site [chemical binding]; other site 710685006969 active site 710685006970 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685006971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685006972 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685006973 acyl-activating enzyme (AAE) consensus motif; other site 710685006974 acyl-activating enzyme (AAE) consensus motif; other site 710685006975 putative AMP binding site [chemical binding]; other site 710685006976 putative active site [active] 710685006977 putative CoA binding site [chemical binding]; other site 710685006978 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710685006979 classical (c) SDRs; Region: SDR_c; cd05233 710685006980 NAD(P) binding site [chemical binding]; other site 710685006981 active site 710685006982 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 710685006983 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710685006984 acyl-activating enzyme (AAE) consensus motif; other site 710685006985 putative AMP binding site [chemical binding]; other site 710685006986 putative active site [active] 710685006987 putative CoA binding site [chemical binding]; other site 710685006988 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710685006989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685006990 DNA-binding site [nucleotide binding]; DNA binding site 710685006991 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710685006992 PQQ-like domain; Region: PQQ_2; pfam13360 710685006993 Strictosidine synthase; Region: Str_synth; pfam03088 710685006994 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 710685006995 PQQ-like domain; Region: PQQ_2; pfam13360 710685006996 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685006997 classical (c) SDRs; Region: SDR_c; cd05233 710685006998 NAD(P) binding site [chemical binding]; other site 710685006999 active site 710685007000 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007001 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685007002 [2Fe-2S] cluster binding site [ion binding]; other site 710685007003 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685007004 hydrophobic ligand binding site; other site 710685007005 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685007006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685007007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685007008 NAD(P) binding site [chemical binding]; other site 710685007009 active site 710685007010 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685007011 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685007012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685007013 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685007014 active site 710685007015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685007016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685007017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685007018 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685007019 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710685007020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685007021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685007022 active site 710685007023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685007024 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685007025 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685007026 active site 710685007027 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710685007028 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685007029 PYR/PP interface [polypeptide binding]; other site 710685007030 dimer interface [polypeptide binding]; other site 710685007031 TPP binding site [chemical binding]; other site 710685007032 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685007033 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710685007034 TPP-binding site; other site 710685007035 dimer interface [polypeptide binding]; other site 710685007036 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 710685007037 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007038 NAD binding site [chemical binding]; other site 710685007039 catalytic residues [active] 710685007040 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710685007041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 710685007042 active site 710685007043 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710685007044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685007045 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710685007046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685007047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685007048 NAD(P) binding site [chemical binding]; other site 710685007049 active site 710685007050 Integrase core domain; Region: rve; pfam00665 710685007051 Integrase core domain; Region: rve_3; cl15866 710685007052 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 710685007053 AAA ATPase domain; Region: AAA_16; pfam13191 710685007054 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710685007055 TniQ; Region: TniQ; pfam06527 710685007056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685007057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685007058 non-specific DNA binding site [nucleotide binding]; other site 710685007059 salt bridge; other site 710685007060 sequence-specific DNA binding site [nucleotide binding]; other site 710685007061 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 710685007062 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710685007063 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710685007064 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007065 metal-binding site [ion binding] 710685007066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685007067 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007068 metal-binding site [ion binding] 710685007069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685007070 S-adenosylmethionine binding site [chemical binding]; other site 710685007071 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 710685007072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685007073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685007074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685007075 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685007076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685007077 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685007078 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685007079 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685007080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685007081 active site 710685007082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685007083 phosphorylation site [posttranslational modification] 710685007084 intermolecular recognition site; other site 710685007085 dimerization interface [polypeptide binding]; other site 710685007086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685007087 DNA binding site [nucleotide binding] 710685007088 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685007089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685007090 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685007091 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710685007092 DNA binding residues [nucleotide binding] 710685007093 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685007094 cyclase homology domain; Region: CHD; cd07302 710685007095 nucleotidyl binding site; other site 710685007096 metal binding site [ion binding]; metal-binding site 710685007097 dimer interface [polypeptide binding]; other site 710685007098 metallochaperone-like domain; Region: TRASH; smart00746 710685007099 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710685007100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685007101 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710685007102 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685007103 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685007104 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685007105 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685007106 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685007107 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710685007108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685007109 dimer interface [polypeptide binding]; other site 710685007110 phosphorylation site [posttranslational modification] 710685007111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685007112 ATP binding site [chemical binding]; other site 710685007113 Mg2+ binding site [ion binding]; other site 710685007114 G-X-G motif; other site 710685007115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685007116 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 710685007117 active site 710685007118 phosphorylation site [posttranslational modification] 710685007119 intermolecular recognition site; other site 710685007120 dimerization interface [polypeptide binding]; other site 710685007121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685007122 DNA binding site [nucleotide binding] 710685007123 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710685007124 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710685007125 Multicopper oxidase; Region: Cu-oxidase; pfam00394 710685007126 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710685007127 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685007128 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685007129 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710685007130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685007131 catalytic residues [active] 710685007132 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710685007133 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685007134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685007135 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685007136 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710685007137 Peptidase family M48; Region: Peptidase_M48; cl12018 710685007138 Putative esterase; Region: Esterase; pfam00756 710685007139 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710685007140 Peptidase family M23; Region: Peptidase_M23; pfam01551 710685007141 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 710685007142 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710685007143 putative active site [active] 710685007144 catalytic triad [active] 710685007145 putative dimer interface [polypeptide binding]; other site 710685007146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685007147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685007148 active site 710685007149 phosphorylation site [posttranslational modification] 710685007150 intermolecular recognition site; other site 710685007151 dimerization interface [polypeptide binding]; other site 710685007152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685007153 DNA binding site [nucleotide binding] 710685007154 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710685007155 Cupin domain; Region: Cupin_2; pfam07883 710685007156 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710685007157 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 710685007158 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710685007159 dimer interface [polypeptide binding]; other site 710685007160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685007161 catalytic residue [active] 710685007162 multidrug resistance protein MdtH; Provisional; Region: PRK11646 710685007163 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 710685007164 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 710685007165 dimerization interface [polypeptide binding]; other site 710685007166 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710685007167 putative homodimer interface [polypeptide binding]; other site 710685007168 putative homotetramer interface [polypeptide binding]; other site 710685007169 putative allosteric switch controlling residues; other site 710685007170 putative metal binding site [ion binding]; other site 710685007171 putative homodimer-homodimer interface [polypeptide binding]; other site 710685007172 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 710685007173 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007174 metal-binding site [ion binding] 710685007175 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710685007176 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710685007177 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 710685007178 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710685007179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685007180 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710685007181 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710685007182 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710685007183 Predicted membrane protein [Function unknown]; Region: COG3462 710685007184 Short C-terminal domain; Region: SHOCT; pfam09851 710685007185 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710685007186 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710685007187 active site residue [active] 710685007188 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710685007189 active site residue [active] 710685007190 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 710685007191 PAP2 superfamily; Region: PAP2; pfam01569 710685007192 active site 710685007193 PAP2 superfamily; Region: PAP2; pfam01569 710685007194 serine/threonine protein kinase; Provisional; Region: PRK14879 710685007195 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710685007196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685007197 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685007198 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007199 metal-binding site [ion binding] 710685007200 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710685007201 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685007202 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710685007203 putative phosphoketolase; Provisional; Region: PRK05261 710685007204 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 710685007205 TPP-binding site; other site 710685007206 XFP C-terminal domain; Region: XFP_C; pfam09363 710685007207 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710685007208 putative homodimer interface [polypeptide binding]; other site 710685007209 putative homotetramer interface [polypeptide binding]; other site 710685007210 putative allosteric switch controlling residues; other site 710685007211 putative metal binding site [ion binding]; other site 710685007212 putative homodimer-homodimer interface [polypeptide binding]; other site 710685007213 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007214 metal-binding site [ion binding] 710685007215 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710685007216 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685007217 metal-binding site [ion binding] 710685007218 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685007219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710685007220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685007221 S-adenosylmethionine binding site [chemical binding]; other site 710685007222 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 710685007223 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710685007224 active site 710685007225 catalytic triad [active] 710685007226 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710685007227 putative active site [active] 710685007228 putative CoA binding site [chemical binding]; other site 710685007229 nudix motif; other site 710685007230 metal binding site [ion binding]; metal-binding site 710685007231 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 710685007232 ABC1 family; Region: ABC1; cl17513 710685007233 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710685007234 active site 710685007235 ATP binding site [chemical binding]; other site 710685007236 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710685007237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685007238 motif II; other site 710685007239 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710685007240 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710685007241 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710685007242 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710685007243 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710685007244 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710685007245 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710685007246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685007247 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685007248 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710685007249 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685007250 Walker A/P-loop; other site 710685007251 ATP binding site [chemical binding]; other site 710685007252 Q-loop/lid; other site 710685007253 ABC transporter signature motif; other site 710685007254 Walker B; other site 710685007255 D-loop; other site 710685007256 H-loop/switch region; other site 710685007257 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710685007258 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710685007259 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710685007260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685007261 catalytic residues [active] 710685007262 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710685007263 CopC domain; Region: CopC; pfam04234 710685007264 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710685007265 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 710685007266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685007267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685007268 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685007269 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685007270 VirB8 protein; Region: VirB8; cl01500 710685007271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685007272 dimerization interface [polypeptide binding]; other site 710685007273 putative DNA binding site [nucleotide binding]; other site 710685007274 putative Zn2+ binding site [ion binding]; other site 710685007275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 710685007276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685007277 putative metal binding site [ion binding]; other site 710685007278 DinB superfamily; Region: DinB_2; pfam12867 710685007279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685007280 dimerization interface [polypeptide binding]; other site 710685007281 putative DNA binding site [nucleotide binding]; other site 710685007282 putative Zn2+ binding site [ion binding]; other site 710685007283 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 710685007284 amphipathic channel; other site 710685007285 Asn-Pro-Ala signature motifs; other site 710685007286 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710685007287 Low molecular weight phosphatase family; Region: LMWPc; cl00105 710685007288 active site 710685007289 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710685007290 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710685007291 active site 710685007292 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 710685007293 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 710685007294 DNA binding residues [nucleotide binding] 710685007295 dimer interface [polypeptide binding]; other site 710685007296 mercury binding site [ion binding]; other site 710685007297 Alkylmercury lyase; Region: MerB; pfam03243 710685007298 Fic/DOC family; Region: Fic; cl00960 710685007299 Divergent AAA domain; Region: AAA_4; pfam04326 710685007300 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 710685007301 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710685007302 Active Sites [active] 710685007303 TniQ; Region: TniQ; pfam06527 710685007304 Short C-terminal domain; Region: SHOCT; pfam09851 710685007305 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 710685007306 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685007307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685007308 motif II; other site 710685007309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685007310 dimerization interface [polypeptide binding]; other site 710685007311 putative DNA binding site [nucleotide binding]; other site 710685007312 putative Zn2+ binding site [ion binding]; other site 710685007313 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710685007314 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710685007315 active site 710685007316 DNA binding site [nucleotide binding] 710685007317 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710685007318 DNA binding site [nucleotide binding] 710685007319 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685007320 active site 710685007321 catalytic residues [active] 710685007322 DNA binding site [nucleotide binding] 710685007323 Int/Topo IB signature motif; other site 710685007324 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710685007325 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007326 active site 710685007327 DNA binding site [nucleotide binding] 710685007328 Int/Topo IB signature motif; other site 710685007329 AAA domain; Region: AAA_22; pfam13401 710685007330 TniQ; Region: TniQ; pfam06527 710685007331 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 710685007332 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 710685007333 tetramer interface [polypeptide binding]; other site 710685007334 active site 710685007335 D-cysteine desulfhydrase; Validated; Region: PRK03910 710685007336 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710685007337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685007338 catalytic residue [active] 710685007339 argininosuccinate lyase; Region: argH; TIGR00838 710685007340 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710685007341 tetramer interface [polypeptide binding]; other site 710685007342 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685007343 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685007344 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007345 active site 710685007346 DNA binding site [nucleotide binding] 710685007347 Int/Topo IB signature motif; other site 710685007348 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007349 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 710685007350 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007351 active site 710685007352 DNA binding site [nucleotide binding] 710685007353 Int/Topo IB signature motif; other site 710685007354 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685007355 MULE transposase domain; Region: MULE; pfam10551 710685007356 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685007357 MULE transposase domain; Region: MULE; pfam10551 710685007358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007359 active site 710685007360 DNA binding site [nucleotide binding] 710685007361 Int/Topo IB signature motif; other site 710685007362 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007363 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 710685007364 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007365 active site 710685007366 DNA binding site [nucleotide binding] 710685007367 Int/Topo IB signature motif; other site 710685007368 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 710685007369 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 710685007370 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 710685007371 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710685007372 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 710685007373 putative di-iron ligands [ion binding]; other site 710685007374 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685007375 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710685007376 tetramer interface [polypeptide binding]; other site 710685007377 D-cysteine desulfhydrase; Validated; Region: PRK03910 710685007378 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710685007379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685007380 catalytic residue [active] 710685007381 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 710685007382 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 710685007383 tetramer interface [polypeptide binding]; other site 710685007384 active site 710685007385 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 710685007386 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 710685007387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685007388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685007389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685007390 NAD(P) binding site [chemical binding]; other site 710685007391 active site 710685007392 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710685007393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685007394 dimer interface [polypeptide binding]; other site 710685007395 conserved gate region; other site 710685007396 putative PBP binding loops; other site 710685007397 ABC-ATPase subunit interface; other site 710685007398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685007399 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 710685007400 Walker A/P-loop; other site 710685007401 ATP binding site [chemical binding]; other site 710685007402 Q-loop/lid; other site 710685007403 ABC transporter signature motif; other site 710685007404 Walker B; other site 710685007405 D-loop; other site 710685007406 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 710685007407 conserved cys residue [active] 710685007408 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 710685007409 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 710685007410 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710685007411 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710685007412 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685007413 substrate binding pocket [chemical binding]; other site 710685007414 membrane-bound complex binding site; other site 710685007415 hinge residues; other site 710685007416 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710685007417 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685007418 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710685007419 Coenzyme A transferase; Region: CoA_trans; cl17247 710685007420 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 710685007421 CoA binding domain; Region: CoA_binding_2; pfam13380 710685007422 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 710685007423 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 710685007424 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 710685007425 substrate binding site [chemical binding]; other site 710685007426 THF binding site; other site 710685007427 zinc-binding site [ion binding]; other site 710685007428 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710685007429 dimerization interface [polypeptide binding]; other site 710685007430 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710685007431 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710685007432 dimerization interface [polypeptide binding]; other site 710685007433 putative path to active site cavity [active] 710685007434 diiron center [ion binding]; other site 710685007435 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710685007436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685007437 catalytic loop [active] 710685007438 iron binding site [ion binding]; other site 710685007439 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710685007440 FAD binding pocket [chemical binding]; other site 710685007441 conserved FAD binding motif [chemical binding]; other site 710685007442 phosphate binding motif [ion binding]; other site 710685007443 beta-alpha-beta structure motif; other site 710685007444 NAD binding pocket [chemical binding]; other site 710685007445 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710685007446 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710685007447 classical (c) SDRs; Region: SDR_c; cd05233 710685007448 NAD(P) binding site [chemical binding]; other site 710685007449 active site 710685007450 Transcription factor WhiB; Region: Whib; pfam02467 710685007451 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685007452 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007453 active site 710685007454 DNA binding site [nucleotide binding] 710685007455 Int/Topo IB signature motif; other site 710685007456 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 710685007457 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007458 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685007459 active site 710685007460 catalytic residues [active] 710685007461 DNA binding site [nucleotide binding] 710685007462 Int/Topo IB signature motif; other site 710685007463 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685007464 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007465 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685007466 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007467 active site 710685007468 DNA binding site [nucleotide binding] 710685007469 Int/Topo IB signature motif; other site 710685007470 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007471 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 710685007472 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007473 active site 710685007474 DNA binding site [nucleotide binding] 710685007475 Int/Topo IB signature motif; other site 710685007476 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685007477 MULE transposase domain; Region: MULE; pfam10551 710685007478 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710685007479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685007480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685007481 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685007482 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710685007483 putative catalytic cysteine [active] 710685007484 Secretory lipase; Region: LIP; pfam03583 710685007485 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685007486 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710685007487 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710685007488 putative di-iron ligands [ion binding]; other site 710685007489 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 710685007490 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 710685007491 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710685007492 conserved cys residue [active] 710685007493 adenylate kinase; Reviewed; Region: adk; PRK00279 710685007494 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710685007495 AMP-binding site [chemical binding]; other site 710685007496 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710685007497 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685007498 Permease; Region: Permease; pfam02405 710685007499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685007500 Permease; Region: Permease; pfam02405 710685007501 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710685007502 mce related protein; Region: MCE; pfam02470 710685007503 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685007504 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007505 mce related protein; Region: MCE; pfam02470 710685007506 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685007507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007508 mce related protein; Region: MCE; pfam02470 710685007509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007510 mce related protein; Region: MCE; pfam02470 710685007511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007512 mce related protein; Region: MCE; pfam02470 710685007513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007514 mce related protein; Region: MCE; pfam02470 710685007515 RDD family; Region: RDD; pfam06271 710685007516 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710685007517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007518 NAD(P) binding site [chemical binding]; other site 710685007519 catalytic residues [active] 710685007520 Protein of unknown function (DUF779); Region: DUF779; pfam05610 710685007521 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710685007522 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685007523 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 710685007524 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685007525 catalytic Zn binding site [ion binding]; other site 710685007526 structural Zn binding site [ion binding]; other site 710685007527 NAD(P) binding site [chemical binding]; other site 710685007528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685007529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685007530 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710685007531 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 710685007532 acyl-activating enzyme (AAE) consensus motif; other site 710685007533 putative AMP binding site [chemical binding]; other site 710685007534 putative active site [active] 710685007535 putative CoA binding site [chemical binding]; other site 710685007536 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710685007537 apolar tunnel; other site 710685007538 heme binding site [chemical binding]; other site 710685007539 dimerization interface [polypeptide binding]; other site 710685007540 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685007541 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685007542 NAD binding site [chemical binding]; other site 710685007543 catalytic Zn binding site [ion binding]; other site 710685007544 substrate binding site [chemical binding]; other site 710685007545 structural Zn binding site [ion binding]; other site 710685007546 AMP-binding domain protein; Validated; Region: PRK08315 710685007547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685007548 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710685007549 acyl-activating enzyme (AAE) consensus motif; other site 710685007550 putative AMP binding site [chemical binding]; other site 710685007551 putative active site [active] 710685007552 putative CoA binding site [chemical binding]; other site 710685007553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685007554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685007555 active site 710685007556 putative acyltransferase; Provisional; Region: PRK05790 710685007557 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685007558 dimer interface [polypeptide binding]; other site 710685007559 active site 710685007560 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685007561 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685007562 substrate binding site [chemical binding]; other site 710685007563 oxyanion hole (OAH) forming residues; other site 710685007564 trimer interface [polypeptide binding]; other site 710685007565 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685007566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685007567 NAD(P) binding site [chemical binding]; other site 710685007568 active site 710685007569 RDD family; Region: RDD; pfam06271 710685007570 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710685007571 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710685007572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685007573 Walker A motif; other site 710685007574 ATP binding site [chemical binding]; other site 710685007575 Walker B motif; other site 710685007576 arginine finger; other site 710685007577 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 710685007578 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710685007579 active site 710685007580 NAD binding site [chemical binding]; other site 710685007581 metal binding site [ion binding]; metal-binding site 710685007582 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 710685007583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710685007584 Walker A motif; other site 710685007585 ATP binding site [chemical binding]; other site 710685007586 Walker B motif; other site 710685007587 arginine finger; other site 710685007588 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 710685007589 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685007590 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007591 NAD(P) binding site [chemical binding]; other site 710685007592 catalytic residues [active] 710685007593 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685007594 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685007595 acyl-activating enzyme (AAE) consensus motif; other site 710685007596 AMP binding site [chemical binding]; other site 710685007597 active site 710685007598 CoA binding site [chemical binding]; other site 710685007599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710685007600 DNA binding site [nucleotide binding] 710685007601 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 710685007602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685007603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685007604 DNA binding residues [nucleotide binding] 710685007605 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 710685007606 Predicted integral membrane protein [Function unknown]; Region: COG5660 710685007607 Putative zinc-finger; Region: zf-HC2; pfam13490 710685007608 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 710685007609 Ammonia monooxygenase; Region: AMO; pfam02461 710685007610 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 710685007611 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 710685007612 RDD family; Region: RDD; pfam06271 710685007613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710685007614 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685007615 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710685007616 dinuclear metal binding motif [ion binding]; other site 710685007617 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710685007618 dinuclear metal binding motif [ion binding]; other site 710685007619 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710685007620 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 710685007621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685007622 catalytic loop [active] 710685007623 iron binding site [ion binding]; other site 710685007624 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710685007625 FAD binding pocket [chemical binding]; other site 710685007626 conserved FAD binding motif [chemical binding]; other site 710685007627 phosphate binding motif [ion binding]; other site 710685007628 beta-alpha-beta structure motif; other site 710685007629 NAD binding pocket [chemical binding]; other site 710685007630 Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964 710685007631 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710685007632 Predicted integral membrane protein [Function unknown]; Region: COG5660 710685007633 Putative zinc-finger; Region: zf-HC2; pfam13490 710685007634 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 710685007635 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 710685007636 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 710685007637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710685007638 Integrase core domain; Region: rve; pfam00665 710685007639 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 710685007640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685007641 active site 710685007642 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 710685007643 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685007644 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685007645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685007646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685007647 S-adenosylmethionine binding site [chemical binding]; other site 710685007648 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 710685007649 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685007650 phosphate binding site [ion binding]; other site 710685007651 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 710685007652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685007653 FeS/SAM binding site; other site 710685007654 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710685007655 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 710685007656 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710685007657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685007659 active site 710685007660 phosphorylation site [posttranslational modification] 710685007661 intermolecular recognition site; other site 710685007662 dimerization interface [polypeptide binding]; other site 710685007663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685007664 DNA binding residues [nucleotide binding] 710685007665 dimerization interface [polypeptide binding]; other site 710685007666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685007667 Histidine kinase; Region: HisKA_3; pfam07730 710685007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685007669 ATP binding site [chemical binding]; other site 710685007670 Mg2+ binding site [ion binding]; other site 710685007671 G-X-G motif; other site 710685007672 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710685007673 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710685007674 active site 710685007675 NAD binding site [chemical binding]; other site 710685007676 metal binding site [ion binding]; metal-binding site 710685007677 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685007678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685007679 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685007680 acetyl-CoA synthetase; Provisional; Region: PRK00174 710685007681 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 710685007682 active site 710685007683 CoA binding site [chemical binding]; other site 710685007684 acyl-activating enzyme (AAE) consensus motif; other site 710685007685 AMP binding site [chemical binding]; other site 710685007686 acetate binding site [chemical binding]; other site 710685007687 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 710685007688 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710685007689 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685007690 active site 710685007691 catalytic residues [active] 710685007692 DNA binding site [nucleotide binding] 710685007693 Int/Topo IB signature motif; other site 710685007694 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685007695 MULE transposase domain; Region: MULE; pfam10551 710685007696 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710685007697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685007698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685007699 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685007700 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710685007701 MULE transposase domain; Region: MULE; pfam10551 710685007702 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007703 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 710685007704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007705 active site 710685007706 DNA binding site [nucleotide binding] 710685007707 Int/Topo IB signature motif; other site 710685007708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007709 active site 710685007710 DNA binding site [nucleotide binding] 710685007711 Int/Topo IB signature motif; other site 710685007712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710685007713 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685007714 active site 710685007715 catalytic residues [active] 710685007716 DNA binding site [nucleotide binding] 710685007717 Int/Topo IB signature motif; other site 710685007718 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685007719 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007720 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 710685007721 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685007722 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 710685007723 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685007724 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685007725 active site 710685007726 catalytic residues [active] 710685007727 DNA binding site [nucleotide binding] 710685007728 Int/Topo IB signature motif; other site 710685007729 AAA domain; Region: AAA_17; pfam13207 710685007730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710685007731 RNA binding surface [nucleotide binding]; other site 710685007732 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 710685007733 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 710685007734 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710685007735 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710685007736 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710685007737 putative dimer interface [polypeptide binding]; other site 710685007738 Predicted transcriptional regulators [Transcription]; Region: COG1733 710685007739 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710685007740 Predicted transcriptional regulators [Transcription]; Region: COG1733 710685007741 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710685007742 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710685007743 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710685007744 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 710685007745 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685007746 active site 710685007747 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685007748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 710685007749 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685007750 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685007751 putative acyl-acceptor binding pocket; other site 710685007752 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 710685007753 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 710685007754 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685007755 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685007756 phosphopeptide binding site; other site 710685007757 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685007758 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685007759 phosphopeptide binding site; other site 710685007760 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710685007761 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 710685007762 Walker A/P-loop; other site 710685007763 ATP binding site [chemical binding]; other site 710685007764 Q-loop/lid; other site 710685007765 ABC transporter signature motif; other site 710685007766 Walker B; other site 710685007767 D-loop; other site 710685007768 H-loop/switch region; other site 710685007769 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710685007770 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685007771 Ligand Binding Site [chemical binding]; other site 710685007772 SIR2-like domain; Region: SIR2_2; pfam13289 710685007773 DNA protecting protein DprA; Region: dprA; TIGR00732 710685007774 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 710685007775 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710685007776 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007777 active site 710685007778 DNA binding site [nucleotide binding] 710685007779 Int/Topo IB signature motif; other site 710685007780 integrase; Provisional; Region: int; PHA02601 710685007781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685007782 active site 710685007783 DNA binding site [nucleotide binding] 710685007784 Int/Topo IB signature motif; other site 710685007785 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685007786 classical (c) SDRs; Region: SDR_c; cd05233 710685007787 NAD(P) binding site [chemical binding]; other site 710685007788 active site 710685007789 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 710685007790 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007791 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 710685007792 alpha subunit interface [polypeptide binding]; other site 710685007793 active site 710685007794 substrate binding site [chemical binding]; other site 710685007795 Fe binding site [ion binding]; other site 710685007796 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 710685007797 oligomerization interface [polypeptide binding]; other site 710685007798 active site 710685007799 metal binding site [ion binding]; metal-binding site 710685007800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685007801 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685007802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685007803 DNA-binding site [nucleotide binding]; DNA binding site 710685007804 FCD domain; Region: FCD; pfam07729 710685007805 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710685007806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685007807 catalytic loop [active] 710685007808 iron binding site [ion binding]; other site 710685007809 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710685007810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685007811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 710685007812 membrane-bound complex binding site; other site 710685007813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685007814 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685007815 NAD(P) binding site [chemical binding]; other site 710685007816 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 710685007817 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685007818 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685007819 Cytochrome P450; Region: p450; cl12078 710685007820 Cytochrome P450; Region: p450; cl12078 710685007821 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685007822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007823 NAD(P) binding site [chemical binding]; other site 710685007824 catalytic residues [active] 710685007825 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710685007826 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685007827 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685007828 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685007829 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007830 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685007831 iron-sulfur cluster [ion binding]; other site 710685007832 [2Fe-2S] cluster binding site [ion binding]; other site 710685007833 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685007834 beta subunit interface [polypeptide binding]; other site 710685007835 alpha subunit interface [polypeptide binding]; other site 710685007836 active site 710685007837 substrate binding site [chemical binding]; other site 710685007838 Fe binding site [ion binding]; other site 710685007839 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007840 inter-subunit interface; other site 710685007841 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 710685007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685007843 NAD(P) binding site [chemical binding]; other site 710685007844 active site 710685007845 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685007846 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685007847 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710685007848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685007849 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 710685007850 Cupin domain; Region: Cupin_2; pfam07883 710685007851 Cupin domain; Region: Cupin_2; pfam07883 710685007852 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 710685007853 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685007854 putative active site [active] 710685007855 catalytic residue [active] 710685007856 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710685007857 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710685007858 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710685007859 active site 710685007860 Fe binding site [ion binding]; other site 710685007861 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710685007862 Class I aldolases; Region: Aldolase_Class_I; cl17187 710685007863 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685007864 catalytic residue [active] 710685007865 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007866 inter-subunit interface; other site 710685007867 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 710685007868 L-aspartate oxidase; Provisional; Region: PRK06175 710685007869 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710685007870 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 710685007871 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 710685007872 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007873 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 710685007874 NAD(P) binding site [chemical binding]; other site 710685007875 catalytic residues [active] 710685007876 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007877 inter-subunit interface; other site 710685007878 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007879 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 710685007880 alpha subunit interaction site [polypeptide binding]; other site 710685007881 beta subunit interaction site [polypeptide binding]; other site 710685007882 iron-sulfur cluster [ion binding]; other site 710685007883 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685007884 beta subunit interface [polypeptide binding]; other site 710685007885 alpha subunit interface [polypeptide binding]; other site 710685007886 active site 710685007887 substrate binding site [chemical binding]; other site 710685007888 Fe binding site [ion binding]; other site 710685007889 short chain dehydrogenase; Provisional; Region: PRK06138 710685007890 classical (c) SDRs; Region: SDR_c; cd05233 710685007891 NAD(P) binding site [chemical binding]; other site 710685007892 active site 710685007893 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685007894 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 710685007895 putative NAD(P) binding site [chemical binding]; other site 710685007896 catalytic Zn binding site [ion binding]; other site 710685007897 VPS10 domain; Region: VPS10; smart00602 710685007898 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007899 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685007900 [2Fe-2S] cluster binding site [ion binding]; other site 710685007901 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685007902 hydrophobic ligand binding site; other site 710685007903 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685007904 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710685007905 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710685007906 active site 710685007907 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685007908 Permease; Region: Permease; pfam02405 710685007909 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685007910 Permease; Region: Permease; pfam02405 710685007911 mce related protein; Region: MCE; pfam02470 710685007912 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685007913 mce related protein; Region: MCE; pfam02470 710685007914 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685007915 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007916 mce related protein; Region: MCE; pfam02470 710685007917 mce related protein; Region: MCE; pfam02470 710685007918 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007919 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007920 mce related protein; Region: MCE; pfam02470 710685007921 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685007922 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685007923 mce related protein; Region: MCE; pfam02470 710685007924 Epoxide hydrolase N terminus; Region: EHN; pfam06441 710685007925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685007926 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685007927 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685007928 NAD(P) binding site [chemical binding]; other site 710685007929 catalytic residues [active] 710685007930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685007931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685007932 putative substrate translocation pore; other site 710685007933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685007934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685007935 putative DNA binding site [nucleotide binding]; other site 710685007936 putative Zn2+ binding site [ion binding]; other site 710685007937 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007938 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 710685007939 alpha subunit interaction site [polypeptide binding]; other site 710685007940 beta subunit interaction site [polypeptide binding]; other site 710685007941 iron-sulfur cluster [ion binding]; other site 710685007942 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685007943 beta subunit interface [polypeptide binding]; other site 710685007944 alpha subunit interface [polypeptide binding]; other site 710685007945 active site 710685007946 substrate binding site [chemical binding]; other site 710685007947 Fe binding site [ion binding]; other site 710685007948 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007949 inter-subunit interface; other site 710685007950 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685007951 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 710685007952 putative NAD(P) binding site [chemical binding]; other site 710685007953 catalytic Zn binding site [ion binding]; other site 710685007954 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685007955 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685007956 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685007957 active site 710685007958 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685007959 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685007960 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685007961 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685007962 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685007963 iron-sulfur cluster [ion binding]; other site 710685007964 [2Fe-2S] cluster binding site [ion binding]; other site 710685007965 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685007966 beta subunit interface [polypeptide binding]; other site 710685007967 alpha subunit interface [polypeptide binding]; other site 710685007968 active site 710685007969 substrate binding site [chemical binding]; other site 710685007970 Fe binding site [ion binding]; other site 710685007971 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007972 inter-subunit interface; other site 710685007973 Cupin domain; Region: Cupin_2; pfam07883 710685007974 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 710685007975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685007976 MarR family; Region: MarR; pfam01047 710685007977 MarR family; Region: MarR_2; cl17246 710685007978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685007979 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685007980 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685007981 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685007982 iron-sulfur cluster [ion binding]; other site 710685007983 [2Fe-2S] cluster binding site [ion binding]; other site 710685007984 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685007985 beta subunit interface [polypeptide binding]; other site 710685007986 alpha subunit interface [polypeptide binding]; other site 710685007987 active site 710685007988 substrate binding site [chemical binding]; other site 710685007989 Fe binding site [ion binding]; other site 710685007990 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685007991 inter-subunit interface; other site 710685007992 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685007993 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685007994 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710685007995 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 710685007996 active site 710685007997 metal binding site [ion binding]; metal-binding site 710685007998 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 710685007999 intersubunit interface [polypeptide binding]; other site 710685008000 active site 710685008001 Zn2+ binding site [ion binding]; other site 710685008002 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 710685008003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008004 NAD(P) binding site [chemical binding]; other site 710685008005 active site 710685008006 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710685008007 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710685008008 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710685008009 active site 710685008010 Fe binding site [ion binding]; other site 710685008011 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685008012 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 710685008013 alpha subunit interaction site [polypeptide binding]; other site 710685008014 beta subunit interaction site [polypeptide binding]; other site 710685008015 iron-sulfur cluster [ion binding]; other site 710685008016 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 710685008017 beta subunit interface [polypeptide binding]; other site 710685008018 alpha subunit interface [polypeptide binding]; other site 710685008019 active site 710685008020 substrate binding site [chemical binding]; other site 710685008021 Fe binding site [ion binding]; other site 710685008022 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710685008023 inter-subunit interface; other site 710685008024 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685008025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685008026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710685008027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685008028 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 710685008029 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710685008030 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710685008031 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685008032 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710685008033 active site 710685008034 inhibitor site; inhibition site 710685008035 dimer interface [polypeptide binding]; other site 710685008036 catalytic residue [active] 710685008037 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710685008038 Cupin domain; Region: Cupin_2; pfam07883 710685008039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685008040 MarR family; Region: MarR; pfam01047 710685008041 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685008042 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685008043 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685008044 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710685008045 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 710685008046 active site 710685008047 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710685008048 active site 710685008049 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710685008050 tetramer interface [polypeptide binding]; other site 710685008051 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685008052 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685008053 Coenzyme A transferase; Region: CoA_trans; cl17247 710685008054 Coenzyme A transferase; Region: CoA_trans; cl17247 710685008055 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710685008056 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710685008057 active site 710685008058 catalytic residues [active] 710685008059 DNA binding site [nucleotide binding] 710685008060 Int/Topo IB signature motif; other site 710685008061 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685008062 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685008063 Uncharacterized conserved protein [Function unknown]; Region: COG2442 710685008064 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710685008065 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710685008066 dimer interface [polypeptide binding]; other site 710685008067 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685008068 Ligand Binding Site [chemical binding]; other site 710685008069 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685008070 Ligand Binding Site [chemical binding]; other site 710685008071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685008072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685008073 active site 710685008074 phosphorylation site [posttranslational modification] 710685008075 intermolecular recognition site; other site 710685008076 dimerization interface [polypeptide binding]; other site 710685008077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685008078 DNA binding residues [nucleotide binding] 710685008079 dimerization interface [polypeptide binding]; other site 710685008080 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685008081 Ligand Binding Site [chemical binding]; other site 710685008082 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710685008083 Ligand Binding Site [chemical binding]; other site 710685008084 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710685008085 dimer interface [polypeptide binding]; other site 710685008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 710685008087 Predicted kinase [General function prediction only]; Region: COG0645 710685008088 AAA domain; Region: AAA_17; pfam13207 710685008089 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685008090 Ligand Binding Site [chemical binding]; other site 710685008091 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 710685008092 30S subunit binding site; other site 710685008093 hypothetical protein; Provisional; Region: PRK07877 710685008094 hypothetical protein; Provisional; Region: PRK07877 710685008095 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 710685008096 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710685008097 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 710685008098 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710685008099 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710685008100 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685008101 GAF domain; Region: GAF; pfam01590 710685008102 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685008103 GAF domain; Region: GAF_3; pfam13492 710685008104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685008105 Histidine kinase; Region: HisKA_3; pfam07730 710685008106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685008107 ATP binding site [chemical binding]; other site 710685008108 Mg2+ binding site [ion binding]; other site 710685008109 G-X-G motif; other site 710685008110 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 710685008111 Subunit I/III interface [polypeptide binding]; other site 710685008112 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 710685008113 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685008114 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 710685008115 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710685008116 putative anti-sigmaE protein; Provisional; Region: PRK13920 710685008117 Anti-sigma-K factor rskA; Region: RskA; pfam10099 710685008118 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 710685008119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685008120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685008121 DNA binding residues [nucleotide binding] 710685008122 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 710685008123 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685008124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685008125 S-adenosylmethionine binding site [chemical binding]; other site 710685008126 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 710685008127 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 710685008128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685008129 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710685008130 putative active site pocket [active] 710685008131 dimerization interface [polypeptide binding]; other site 710685008132 putative catalytic residue [active] 710685008133 Protein of unknown function (DUF867); Region: DUF867; pfam05908 710685008134 manganese transport protein MntH; Reviewed; Region: PRK00701 710685008135 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710685008136 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685008137 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685008138 short chain dehydrogenase; Provisional; Region: PRK07814 710685008139 classical (c) SDRs; Region: SDR_c; cd05233 710685008140 NAD(P) binding site [chemical binding]; other site 710685008141 active site 710685008142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685008143 S-adenosylmethionine binding site [chemical binding]; other site 710685008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008146 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 710685008147 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 710685008148 putative DNA binding site [nucleotide binding]; other site 710685008149 putative homodimer interface [polypeptide binding]; other site 710685008150 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 710685008151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710685008152 putative substrate binding site [chemical binding]; other site 710685008153 putative ATP binding site [chemical binding]; other site 710685008154 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 710685008155 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 710685008156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 710685008157 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685008158 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 710685008159 inhibitor binding site; inhibition site 710685008160 catalytic Zn binding site [ion binding]; other site 710685008161 structural Zn binding site [ion binding]; other site 710685008162 NADP binding site [chemical binding]; other site 710685008163 tetramer interface [polypeptide binding]; other site 710685008164 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 710685008165 MarR family; Region: MarR_2; pfam12802 710685008166 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 710685008167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710685008168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710685008169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710685008170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710685008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685008172 dimer interface [polypeptide binding]; other site 710685008173 putative PBP binding loops; other site 710685008174 ABC-ATPase subunit interface; other site 710685008175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710685008176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685008177 dimer interface [polypeptide binding]; other site 710685008178 conserved gate region; other site 710685008179 putative PBP binding loops; other site 710685008180 ABC-ATPase subunit interface; other site 710685008181 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710685008182 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710685008183 Walker A/P-loop; other site 710685008184 ATP binding site [chemical binding]; other site 710685008185 Q-loop/lid; other site 710685008186 ABC transporter signature motif; other site 710685008187 Walker B; other site 710685008188 D-loop; other site 710685008189 H-loop/switch region; other site 710685008190 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 710685008191 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 710685008192 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685008193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685008194 active site 710685008195 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 710685008196 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 710685008197 nucleotide binding site [chemical binding]; other site 710685008198 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 710685008199 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710685008200 active site 710685008201 DNA binding site [nucleotide binding] 710685008202 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710685008203 DNA binding site [nucleotide binding] 710685008204 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685008205 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685008206 active site 710685008207 ATP binding site [chemical binding]; other site 710685008208 substrate binding site [chemical binding]; other site 710685008209 activation loop (A-loop); other site 710685008210 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710685008211 Kelch domain; Region: Kelch; smart00612 710685008212 Kelch motif; Region: Kelch_1; pfam01344 710685008213 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710685008214 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 710685008215 Kelch motif; Region: Kelch_1; pfam01344 710685008216 Kelch motif; Region: Kelch_6; pfam13964 710685008217 Kelch motif; Region: Kelch_1; pfam01344 710685008218 Kelch domain; Region: Kelch; smart00612 710685008219 Kelch motif; Region: Kelch_1; pfam01344 710685008220 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710685008221 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685008222 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685008223 phosphopeptide binding site; other site 710685008224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685008225 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 710685008226 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 710685008227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685008228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685008229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685008230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685008231 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685008232 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685008233 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 710685008234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685008235 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710685008236 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710685008237 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 710685008238 active site 710685008239 SAM binding site [chemical binding]; other site 710685008240 homodimer interface [polypeptide binding]; other site 710685008241 Predicted membrane protein [Function unknown]; Region: COG1950 710685008242 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710685008243 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 710685008244 putative DNA binding site [nucleotide binding]; other site 710685008245 catalytic residue [active] 710685008246 putative H2TH interface [polypeptide binding]; other site 710685008247 putative catalytic residues [active] 710685008248 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710685008249 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710685008250 chorismate mutase; Provisional; Region: PRK09269 710685008251 Chorismate mutase type II; Region: CM_2; cl00693 710685008252 short chain dehydrogenase; Provisional; Region: PRK08251 710685008253 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 710685008254 putative NAD(P) binding site [chemical binding]; other site 710685008255 active site 710685008256 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 710685008257 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 710685008258 active site 710685008259 dimer interface [polypeptide binding]; other site 710685008260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 710685008261 dimer interface [polypeptide binding]; other site 710685008262 active site 710685008263 succinic semialdehyde dehydrogenase; Region: PLN02278 710685008264 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710685008265 tetramerization interface [polypeptide binding]; other site 710685008266 NAD(P) binding site [chemical binding]; other site 710685008267 catalytic residues [active] 710685008268 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685008269 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710685008270 active site 710685008271 catalytic triad [active] 710685008272 oxyanion hole [active] 710685008273 hypothetical protein; Provisional; Region: PRK07857 710685008274 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710685008275 Part of AAA domain; Region: AAA_19; pfam13245 710685008276 Family description; Region: UvrD_C_2; pfam13538 710685008277 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710685008278 Peptidase family M23; Region: Peptidase_M23; pfam01551 710685008279 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 710685008280 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 710685008281 CoA-ligase; Region: Ligase_CoA; pfam00549 710685008282 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 710685008283 CoA binding domain; Region: CoA_binding; smart00881 710685008284 CoA-ligase; Region: Ligase_CoA; pfam00549 710685008285 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710685008286 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685008287 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685008288 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685008289 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 710685008290 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 710685008291 active site 710685008292 dimer interface [polypeptide binding]; other site 710685008293 non-prolyl cis peptide bond; other site 710685008294 insertion regions; other site 710685008295 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 710685008296 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 710685008297 active site 710685008298 substrate binding site [chemical binding]; other site 710685008299 cosubstrate binding site; other site 710685008300 catalytic site [active] 710685008301 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 710685008302 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 710685008303 purine monophosphate binding site [chemical binding]; other site 710685008304 dimer interface [polypeptide binding]; other site 710685008305 putative catalytic residues [active] 710685008306 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 710685008307 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 710685008308 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 710685008309 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 710685008310 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710685008311 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 710685008312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710685008313 metal ion-dependent adhesion site (MIDAS); other site 710685008314 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710685008315 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 710685008316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008317 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710685008318 NAD(P) binding site [chemical binding]; other site 710685008319 active site 710685008320 enoyl-CoA hydratase; Provisional; Region: PRK07827 710685008321 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008322 substrate binding site [chemical binding]; other site 710685008323 oxyanion hole (OAH) forming residues; other site 710685008324 trimer interface [polypeptide binding]; other site 710685008325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685008326 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685008327 active site 710685008328 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710685008329 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685008330 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685008331 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710685008332 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685008333 carboxyltransferase (CT) interaction site; other site 710685008334 biotinylation site [posttranslational modification]; other site 710685008335 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685008336 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685008337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685008338 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685008339 active site 710685008340 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 710685008341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685008342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685008343 active site 710685008344 phosphorylation site [posttranslational modification] 710685008345 intermolecular recognition site; other site 710685008346 dimerization interface [polypeptide binding]; other site 710685008347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685008348 DNA binding site [nucleotide binding] 710685008349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685008350 dimerization interface [polypeptide binding]; other site 710685008351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685008352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685008353 dimer interface [polypeptide binding]; other site 710685008354 phosphorylation site [posttranslational modification] 710685008355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685008356 ATP binding site [chemical binding]; other site 710685008357 Mg2+ binding site [ion binding]; other site 710685008358 G-X-G motif; other site 710685008359 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710685008360 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685008361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710685008362 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710685008363 MPT binding site; other site 710685008364 trimer interface [polypeptide binding]; other site 710685008365 MspA; Region: MspA; pfam09203 710685008366 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 710685008367 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 710685008368 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 710685008369 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 710685008370 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 710685008371 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 710685008372 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 710685008373 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 710685008374 active site 710685008375 tetramer interface; other site 710685008376 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710685008377 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710685008378 dimer interface [polypeptide binding]; other site 710685008379 putative functional site; other site 710685008380 putative MPT binding site; other site 710685008381 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710685008382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710685008383 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710685008384 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710685008385 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710685008386 catalytic triad [active] 710685008387 Protein of unknown function (DUF742); Region: DUF742; pfam05331 710685008388 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 710685008389 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008390 mce related protein; Region: MCE; pfam02470 710685008391 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008392 mce related protein; Region: MCE; pfam02470 710685008393 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008394 mce related protein; Region: MCE; pfam02470 710685008395 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008396 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008397 mce related protein; Region: MCE; pfam02470 710685008398 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008399 mce related protein; Region: MCE; pfam02470 710685008400 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008401 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008402 mce related protein; Region: MCE; pfam02470 710685008403 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008406 enoyl-CoA hydratase; Provisional; Region: PRK07509 710685008407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008408 substrate binding site [chemical binding]; other site 710685008409 oxyanion hole (OAH) forming residues; other site 710685008410 trimer interface [polypeptide binding]; other site 710685008411 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710685008412 Ecdysteroid kinase; Region: EcKinase; cl17738 710685008413 lipid-transfer protein; Provisional; Region: PRK08256 710685008414 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685008415 active site 710685008416 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685008417 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685008418 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 710685008419 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710685008420 nucleotide binding site [chemical binding]; other site 710685008421 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 710685008422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008423 NAD(P) binding site [chemical binding]; other site 710685008424 active site 710685008425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685008426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685008427 ligand binding site [chemical binding]; other site 710685008428 flexible hinge region; other site 710685008429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710685008430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685008431 Coenzyme A binding pocket [chemical binding]; other site 710685008432 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 710685008433 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710685008434 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710685008435 shikimate binding site; other site 710685008436 NAD(P) binding site [chemical binding]; other site 710685008437 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710685008438 PE-PPE domain; Region: PE-PPE; pfam08237 710685008439 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 710685008440 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 710685008441 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 710685008442 DNA binding residues [nucleotide binding] 710685008443 dimer interface [polypeptide binding]; other site 710685008444 [2Fe-2S] cluster binding site [ion binding]; other site 710685008445 arginine deiminase; Provisional; Region: PRK01388 710685008446 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710685008447 Predicted methyltransferases [General function prediction only]; Region: COG0313 710685008448 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 710685008449 putative SAM binding site [chemical binding]; other site 710685008450 putative homodimer interface [polypeptide binding]; other site 710685008451 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 710685008452 chorismate binding enzyme; Region: Chorismate_bind; cl10555 710685008453 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710685008454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685008455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685008456 DNA binding residues [nucleotide binding] 710685008457 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685008458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685008459 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710685008460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685008461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685008462 DNA binding residues [nucleotide binding] 710685008463 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685008464 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685008465 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685008466 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 710685008467 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710685008468 active site 710685008469 HIGH motif; other site 710685008470 KMSKS motif; other site 710685008471 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710685008472 tRNA binding surface [nucleotide binding]; other site 710685008473 anticodon binding site; other site 710685008474 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710685008475 active site 710685008476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 710685008477 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710685008478 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710685008479 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710685008480 G5 domain; Region: G5; pfam07501 710685008481 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710685008482 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 710685008483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685008484 S-adenosylmethionine binding site [chemical binding]; other site 710685008485 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685008486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685008487 active site 710685008488 ATP binding site [chemical binding]; other site 710685008489 substrate binding site [chemical binding]; other site 710685008490 activation loop (A-loop); other site 710685008491 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 710685008492 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710685008493 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710685008494 acyl-activating enzyme (AAE) consensus motif; other site 710685008495 active site 710685008496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685008497 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710685008498 Walker A/P-loop; other site 710685008499 ATP binding site [chemical binding]; other site 710685008500 Q-loop/lid; other site 710685008501 ABC transporter signature motif; other site 710685008502 Walker B; other site 710685008503 D-loop; other site 710685008504 H-loop/switch region; other site 710685008505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685008506 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710685008507 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685008508 putative active site [active] 710685008509 putative substrate binding site [chemical binding]; other site 710685008510 ATP binding site [chemical binding]; other site 710685008511 Phosphotransferase enzyme family; Region: APH; pfam01636 710685008512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008514 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 710685008515 4Fe-4S binding domain; Region: Fer4; pfam00037 710685008516 Cutinase; Region: Cutinase; pfam01083 710685008517 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710685008518 putative active site [active] 710685008519 catalytic residue [active] 710685008520 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 710685008521 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 710685008522 5S rRNA interface [nucleotide binding]; other site 710685008523 CTC domain interface [polypeptide binding]; other site 710685008524 L16 interface [polypeptide binding]; other site 710685008525 short chain dehydrogenase; Provisional; Region: PRK06197 710685008526 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710685008527 putative NAD(P) binding site [chemical binding]; other site 710685008528 active site 710685008529 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710685008530 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 710685008531 ArsC family; Region: ArsC; pfam03960 710685008532 catalytic residues [active] 710685008533 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710685008534 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 710685008535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685008536 active site 710685008537 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 710685008538 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 710685008539 Substrate binding site; other site 710685008540 Mg++ binding site; other site 710685008541 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 710685008542 active site 710685008543 substrate binding site [chemical binding]; other site 710685008544 CoA binding site [chemical binding]; other site 710685008545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008547 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 710685008548 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 710685008549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685008550 ATP binding site [chemical binding]; other site 710685008551 putative Mg++ binding site [ion binding]; other site 710685008552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685008553 nucleotide binding region [chemical binding]; other site 710685008554 ATP-binding site [chemical binding]; other site 710685008555 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 710685008556 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 710685008557 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 710685008558 homodimer interface [polypeptide binding]; other site 710685008559 metal binding site [ion binding]; metal-binding site 710685008560 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710685008561 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710685008562 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710685008563 enolase; Provisional; Region: eno; PRK00077 710685008564 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710685008565 dimer interface [polypeptide binding]; other site 710685008566 metal binding site [ion binding]; metal-binding site 710685008567 substrate binding pocket [chemical binding]; other site 710685008568 Septum formation initiator; Region: DivIC; pfam04977 710685008569 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 710685008570 Uncharacterized conserved protein [Function unknown]; Region: COG1507 710685008571 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710685008572 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710685008573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685008574 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710685008575 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710685008576 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 710685008577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685008578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685008579 catalytic residue [active] 710685008580 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 710685008581 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685008582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008583 substrate binding site [chemical binding]; other site 710685008584 oxyanion hole (OAH) forming residues; other site 710685008585 trimer interface [polypeptide binding]; other site 710685008586 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685008587 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685008588 [2Fe-2S] cluster binding site [ion binding]; other site 710685008589 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 710685008590 putative alpha subunit interface [polypeptide binding]; other site 710685008591 putative active site [active] 710685008592 putative substrate binding site [chemical binding]; other site 710685008593 Fe binding site [ion binding]; other site 710685008594 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 710685008595 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685008596 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 710685008597 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710685008598 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710685008599 PaaX-like protein; Region: PaaX; pfam07848 710685008600 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 710685008601 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710685008602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685008603 acyl-activating enzyme (AAE) consensus motif; other site 710685008604 AMP binding site [chemical binding]; other site 710685008605 active site 710685008606 CoA binding site [chemical binding]; other site 710685008607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685008608 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685008609 hydrophobic ligand binding site; other site 710685008610 Domain of unknown function (DUF309); Region: DUF309; pfam03745 710685008611 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 710685008612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685008613 active site 710685008614 phosphorylation site [posttranslational modification] 710685008615 intermolecular recognition site; other site 710685008616 dimerization interface [polypeptide binding]; other site 710685008617 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685008618 DNA binding site [nucleotide binding] 710685008619 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 710685008620 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 710685008621 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 710685008622 Ligand Binding Site [chemical binding]; other site 710685008623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685008624 dimer interface [polypeptide binding]; other site 710685008625 phosphorylation site [posttranslational modification] 710685008626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685008627 ATP binding site [chemical binding]; other site 710685008628 Mg2+ binding site [ion binding]; other site 710685008629 G-X-G motif; other site 710685008630 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710685008631 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710685008632 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 710685008633 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685008634 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710685008635 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 710685008636 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 710685008637 EamA-like transporter family; Region: EamA; pfam00892 710685008638 EamA-like transporter family; Region: EamA; cl17759 710685008639 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710685008640 catalytic residue [active] 710685008641 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685008642 active site 710685008643 GAF domain; Region: GAF; pfam01590 710685008644 GAF domain; Region: GAF_2; pfam13185 710685008645 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685008646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710685008647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710685008648 metal binding site [ion binding]; metal-binding site 710685008649 active site 710685008650 I-site; other site 710685008651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710685008652 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710685008653 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685008654 DNA binding residues [nucleotide binding] 710685008655 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710685008656 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710685008657 conserved cys residue [active] 710685008658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685008659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685008660 Zn2+ binding site [ion binding]; other site 710685008661 Mg2+ binding site [ion binding]; other site 710685008662 FMN binding site [chemical binding]; other site 710685008663 Nitroreductase family; Region: Nitroreductase; pfam00881 710685008664 dimer interface [polypeptide binding]; other site 710685008665 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710685008666 MASE1; Region: MASE1; cl17823 710685008667 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685008668 GAF domain; Region: GAF; pfam01590 710685008669 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710685008670 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685008671 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 710685008672 putative active site [active] 710685008673 Response regulator receiver domain; Region: Response_reg; pfam00072 710685008674 transcriptional regulator NarL; Provisional; Region: PRK10651 710685008675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710685008676 DNA binding residues [nucleotide binding] 710685008677 dimerization interface [polypeptide binding]; other site 710685008678 Cutinase; Region: Cutinase; pfam01083 710685008679 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 710685008680 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710685008681 conserved cys residue [active] 710685008682 Emopamil binding protein; Region: EBP; pfam05241 710685008683 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685008684 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685008685 molybdopterin cofactor binding site; other site 710685008686 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710685008687 molybdopterin cofactor binding site; other site 710685008688 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685008689 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685008690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685008691 metabolite-proton symporter; Region: 2A0106; TIGR00883 710685008692 putative substrate translocation pore; other site 710685008693 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685008694 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685008695 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685008696 iron-sulfur cluster [ion binding]; other site 710685008697 [2Fe-2S] cluster binding site [ion binding]; other site 710685008698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008699 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685008700 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685008701 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 710685008702 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710685008703 Cl- selectivity filter; other site 710685008704 Cl- binding residues [ion binding]; other site 710685008705 pore gating glutamate residue; other site 710685008706 dimer interface [polypeptide binding]; other site 710685008707 H+/Cl- coupling transport residue; other site 710685008708 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710685008709 nucleoside/Zn binding site; other site 710685008710 dimer interface [polypeptide binding]; other site 710685008711 catalytic motif [active] 710685008712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685008713 anti sigma factor interaction site; other site 710685008714 regulatory phosphorylation site [posttranslational modification]; other site 710685008715 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685008716 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710685008717 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710685008718 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710685008719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685008720 active site 710685008721 phosphorylation site [posttranslational modification] 710685008722 intermolecular recognition site; other site 710685008723 dimerization interface [polypeptide binding]; other site 710685008724 Homeodomain-like domain; Region: HTH_23; pfam13384 710685008725 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 710685008726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685008727 ATP binding site [chemical binding]; other site 710685008728 Mg2+ binding site [ion binding]; other site 710685008729 G-X-G motif; other site 710685008730 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 710685008731 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 710685008732 lipid-transfer protein; Provisional; Region: PRK08256 710685008733 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685008734 active site 710685008735 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685008736 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685008737 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685008738 active site 710685008739 ATP binding site [chemical binding]; other site 710685008740 substrate binding site [chemical binding]; other site 710685008741 activation loop (A-loop); other site 710685008742 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710685008743 DNA binding site [nucleotide binding] 710685008744 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710685008745 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685008746 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685008747 phosphopeptide binding site; other site 710685008748 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685008749 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685008750 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685008751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008752 NAD(P) binding site [chemical binding]; other site 710685008753 active site 710685008754 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710685008755 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 710685008756 putative NAD(P) binding site [chemical binding]; other site 710685008757 catalytic Zn binding site [ion binding]; other site 710685008758 structural Zn binding site [ion binding]; other site 710685008759 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 710685008760 Patatin-like phospholipase; Region: Patatin; pfam01734 710685008761 nucleophile elbow; other site 710685008762 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710685008763 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 710685008764 active site 710685008765 nucleophile elbow; other site 710685008766 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 710685008767 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710685008768 active site residue [active] 710685008769 Predicted membrane protein [Function unknown]; Region: COG4425 710685008770 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710685008771 enoyl-CoA hydratase; Provisional; Region: PRK05862 710685008772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008773 substrate binding site [chemical binding]; other site 710685008774 oxyanion hole (OAH) forming residues; other site 710685008775 trimer interface [polypeptide binding]; other site 710685008776 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 710685008777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008778 substrate binding site [chemical binding]; other site 710685008779 oxyanion hole (OAH) forming residues; other site 710685008780 trimer interface [polypeptide binding]; other site 710685008781 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 710685008782 Bax inhibitor 1 like; Region: BaxI_1; cl17691 710685008783 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710685008784 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 710685008785 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685008786 dimer interface [polypeptide binding]; other site 710685008787 active site 710685008788 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 710685008789 active site 710685008790 catalytic triad [active] 710685008791 oxyanion hole [active] 710685008792 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710685008793 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 710685008794 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710685008795 dimer interface [polypeptide binding]; other site 710685008796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685008797 catalytic residue [active] 710685008798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 710685008799 Interferon-induced transmembrane protein; Region: CD225; pfam04505 710685008800 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 710685008801 RDD family; Region: RDD; pfam06271 710685008802 RDD family; Region: RDD; pfam06271 710685008803 cystathionine gamma-synthase; Provisional; Region: PRK07811 710685008804 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710685008805 homodimer interface [polypeptide binding]; other site 710685008806 substrate-cofactor binding pocket; other site 710685008807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685008808 catalytic residue [active] 710685008809 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 710685008810 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710685008811 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710685008812 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710685008813 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 710685008814 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 710685008815 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 710685008816 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 710685008817 catalytic residues [active] 710685008818 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685008819 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 710685008820 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 710685008821 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710685008822 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 710685008823 catalytic residue [active] 710685008824 putative FPP diphosphate binding site; other site 710685008825 putative FPP binding hydrophobic cleft; other site 710685008826 dimer interface [polypeptide binding]; other site 710685008827 putative IPP diphosphate binding site; other site 710685008828 pantothenate kinase; Provisional; Region: PRK05439 710685008829 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 710685008830 ATP-binding site [chemical binding]; other site 710685008831 CoA-binding site [chemical binding]; other site 710685008832 Mg2+-binding site [ion binding]; other site 710685008833 serine hydroxymethyltransferase; Provisional; Region: PRK13580 710685008834 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710685008835 dimer interface [polypeptide binding]; other site 710685008836 active site 710685008837 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710685008838 folate binding site [chemical binding]; other site 710685008839 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710685008840 dinuclear metal binding motif [ion binding]; other site 710685008841 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 710685008842 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 710685008843 putative active site [active] 710685008844 PhoH-like protein; Region: PhoH; pfam02562 710685008845 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710685008846 Walker A motif; other site 710685008847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685008848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685008849 DNA binding residues [nucleotide binding] 710685008850 dimerization interface [polypeptide binding]; other site 710685008851 fumarate hydratase; Reviewed; Region: fumC; PRK00485 710685008852 Class II fumarases; Region: Fumarase_classII; cd01362 710685008853 active site 710685008854 tetramer interface [polypeptide binding]; other site 710685008855 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 710685008856 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 710685008857 putative active site [active] 710685008858 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 710685008859 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710685008860 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710685008861 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710685008862 classical (c) SDRs; Region: SDR_c; cd05233 710685008863 short chain dehydrogenase; Provisional; Region: PRK05650 710685008864 NAD(P) binding site [chemical binding]; other site 710685008865 active site 710685008866 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685008867 classical (c) SDRs; Region: SDR_c; cd05233 710685008868 NAD(P) binding site [chemical binding]; other site 710685008869 active site 710685008870 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685008871 hydrophobic ligand binding site; other site 710685008872 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710685008873 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710685008874 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 710685008875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685008876 motif II; other site 710685008877 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710685008878 Sulfatase; Region: Sulfatase; pfam00884 710685008879 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 710685008880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008881 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 710685008882 NAD(P) binding site [chemical binding]; other site 710685008883 active site 710685008884 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 710685008885 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 710685008886 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 710685008887 generic binding surface II; other site 710685008888 generic binding surface I; other site 710685008889 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 710685008890 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 710685008891 GTP-binding protein YchF; Reviewed; Region: PRK09601 710685008892 YchF GTPase; Region: YchF; cd01900 710685008893 G1 box; other site 710685008894 GTP/Mg2+ binding site [chemical binding]; other site 710685008895 Switch I region; other site 710685008896 G2 box; other site 710685008897 Switch II region; other site 710685008898 G3 box; other site 710685008899 G4 box; other site 710685008900 G5 box; other site 710685008901 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 710685008902 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685008903 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685008904 Integrase core domain; Region: rve; pfam00665 710685008905 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 710685008906 dimer interface [polypeptide binding]; other site 710685008907 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685008908 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 710685008909 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685008910 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710685008911 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685008912 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 710685008913 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710685008914 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 710685008915 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685008916 cyclase homology domain; Region: CHD; cd07302 710685008917 nucleotidyl binding site; other site 710685008918 metal binding site [ion binding]; metal-binding site 710685008919 dimer interface [polypeptide binding]; other site 710685008920 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685008921 hypothetical protein; Provisional; Region: PRK06149 710685008922 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710685008923 active site 710685008924 ATP binding site [chemical binding]; other site 710685008925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685008926 inhibitor-cofactor binding pocket; inhibition site 710685008927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685008928 catalytic residue [active] 710685008929 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685008930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685008931 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685008932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008934 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 710685008935 dimer interface [polypeptide binding]; other site 710685008936 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685008937 Permease; Region: Permease; pfam02405 710685008938 Permease; Region: Permease; pfam02405 710685008939 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685008940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008941 mce related protein; Region: MCE; pfam02470 710685008942 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008943 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008944 mce related protein; Region: MCE; pfam02470 710685008945 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008946 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008947 mce related protein; Region: MCE; pfam02470 710685008948 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008949 mce related protein; Region: MCE; pfam02470 710685008950 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008951 mce related protein; Region: MCE; pfam02470 710685008952 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685008953 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685008954 mce related protein; Region: MCE; pfam02470 710685008955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685008956 Predicted membrane protein [Function unknown]; Region: COG2259 710685008957 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 710685008958 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685008959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685008960 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710685008961 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710685008962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685008963 dimer interface [polypeptide binding]; other site 710685008964 active site 710685008965 enoyl-CoA hydratase; Provisional; Region: PRK08252 710685008966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008967 substrate binding site [chemical binding]; other site 710685008968 oxyanion hole (OAH) forming residues; other site 710685008969 trimer interface [polypeptide binding]; other site 710685008970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685008971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685008972 active site 710685008973 Fasciclin domain; Region: Fasciclin; pfam02469 710685008974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685008975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685008976 oxidoreductase; Provisional; Region: PRK06196 710685008977 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710685008978 putative NAD(P) binding site [chemical binding]; other site 710685008979 active site 710685008980 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710685008981 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710685008982 trimer interface [polypeptide binding]; other site 710685008983 putative metal binding site [ion binding]; other site 710685008984 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710685008985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685008986 NAD(P) binding site [chemical binding]; other site 710685008987 active site 710685008988 CAAX protease self-immunity; Region: Abi; pfam02517 710685008989 H+ Antiporter protein; Region: 2A0121; TIGR00900 710685008990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685008991 putative substrate translocation pore; other site 710685008992 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685008993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685008994 substrate binding site [chemical binding]; other site 710685008995 oxyanion hole (OAH) forming residues; other site 710685008996 trimer interface [polypeptide binding]; other site 710685008997 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685008998 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685008999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710685009000 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 710685009001 NAD binding site [chemical binding]; other site 710685009002 homodimer interface [polypeptide binding]; other site 710685009003 homotetramer interface [polypeptide binding]; other site 710685009004 active site 710685009005 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710685009006 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685009007 FMN binding site [chemical binding]; other site 710685009008 substrate binding site [chemical binding]; other site 710685009009 putative catalytic residue [active] 710685009010 DoxX; Region: DoxX; pfam07681 710685009011 MMPL family; Region: MMPL; pfam03176 710685009012 MMPL family; Region: MMPL; pfam03176 710685009013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009015 WHG domain; Region: WHG; pfam13305 710685009016 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 710685009017 NAD-dependent deacetylase; Provisional; Region: PRK00481 710685009018 NAD+ binding site [chemical binding]; other site 710685009019 substrate binding site [chemical binding]; other site 710685009020 Zn binding site [ion binding]; other site 710685009021 Predicted transcriptional regulators [Transcription]; Region: COG1725 710685009022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685009023 DNA-binding site [nucleotide binding]; DNA binding site 710685009024 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685009025 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685009026 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 710685009027 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685009028 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685009029 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685009030 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 710685009031 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 710685009032 Na binding site [ion binding]; other site 710685009033 Protein of unknown function, DUF485; Region: DUF485; pfam04341 710685009034 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685009035 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685009036 Na binding site [ion binding]; other site 710685009037 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 710685009038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685009039 active site 710685009040 phosphorylation site [posttranslational modification] 710685009041 intermolecular recognition site; other site 710685009042 dimerization interface [polypeptide binding]; other site 710685009043 LytTr DNA-binding domain; Region: LytTR; smart00850 710685009044 Histidine kinase; Region: His_kinase; pfam06580 710685009045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685009046 ATP binding site [chemical binding]; other site 710685009047 Mg2+ binding site [ion binding]; other site 710685009048 G-X-G motif; other site 710685009049 uncharacterized HhH-GPD family protein; Region: TIGR03252 710685009050 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710685009051 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 710685009052 catalytic residues [active] 710685009053 catalytic nucleophile [active] 710685009054 FMN binding site [chemical binding]; other site 710685009055 Nitroreductase family; Region: Nitroreductase; pfam00881 710685009056 dimer interface [polypeptide binding]; other site 710685009057 mannosyltransferase; Provisional; Region: pimE; PRK13375 710685009058 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 710685009059 aromatic arch; other site 710685009060 DCoH dimer interaction site [polypeptide binding]; other site 710685009061 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 710685009062 DCoH tetramer interaction site [polypeptide binding]; other site 710685009063 substrate binding site [chemical binding]; other site 710685009064 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 710685009065 active site 710685009066 8-oxo-dGMP binding site [chemical binding]; other site 710685009067 nudix motif; other site 710685009068 metal binding site [ion binding]; metal-binding site 710685009069 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685009070 Cytochrome P450; Region: p450; cl12078 710685009071 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 710685009072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 710685009073 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 710685009074 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 710685009075 G1 box; other site 710685009076 putative GEF interaction site [polypeptide binding]; other site 710685009077 GTP/Mg2+ binding site [chemical binding]; other site 710685009078 Switch I region; other site 710685009079 G2 box; other site 710685009080 G3 box; other site 710685009081 Switch II region; other site 710685009082 G4 box; other site 710685009083 G5 box; other site 710685009084 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 710685009085 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 710685009086 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710685009087 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710685009088 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710685009089 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 710685009090 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710685009091 putative ion selectivity filter; other site 710685009092 putative pore gating glutamate residue; other site 710685009093 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 710685009094 FO synthase; Reviewed; Region: fbiC; PRK09234 710685009095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685009096 FeS/SAM binding site; other site 710685009097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685009098 FeS/SAM binding site; other site 710685009099 Uncharacterized conserved protein [Function unknown]; Region: COG2353 710685009100 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710685009101 Ferredoxin [Energy production and conversion]; Region: COG1146 710685009102 4Fe-4S binding domain; Region: Fer4; pfam00037 710685009103 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 710685009104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685009105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685009106 homodimer interface [polypeptide binding]; other site 710685009107 catalytic residue [active] 710685009108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685009109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685009110 active site 710685009111 phosphorylation site [posttranslational modification] 710685009112 intermolecular recognition site; other site 710685009113 dimerization interface [polypeptide binding]; other site 710685009114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685009115 DNA binding residues [nucleotide binding] 710685009116 dimerization interface [polypeptide binding]; other site 710685009117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685009118 Histidine kinase; Region: HisKA_3; pfam07730 710685009119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685009120 ATP binding site [chemical binding]; other site 710685009121 Mg2+ binding site [ion binding]; other site 710685009122 G-X-G motif; other site 710685009123 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710685009124 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710685009125 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710685009126 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710685009127 substrate binding pocket [chemical binding]; other site 710685009128 chain length determination region; other site 710685009129 substrate-Mg2+ binding site; other site 710685009130 catalytic residues [active] 710685009131 aspartate-rich region 1; other site 710685009132 active site lid residues [active] 710685009133 aspartate-rich region 2; other site 710685009134 phytoene desaturase; Region: crtI_fam; TIGR02734 710685009135 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 710685009136 active site lid residues [active] 710685009137 substrate binding pocket [chemical binding]; other site 710685009138 catalytic residues [active] 710685009139 substrate-Mg2+ binding site; other site 710685009140 aspartate-rich region 1; other site 710685009141 aspartate-rich region 2; other site 710685009142 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 710685009143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685009144 Uncharacterized conserved protein [Function unknown]; Region: COG3349 710685009145 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685009146 iron-sulfur cluster [ion binding]; other site 710685009147 [2Fe-2S] cluster binding site [ion binding]; other site 710685009148 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 710685009149 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 710685009150 active site 710685009151 metal binding site [ion binding]; metal-binding site 710685009152 nudix motif; other site 710685009153 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685009154 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 710685009155 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 710685009156 Glutamate binding site [chemical binding]; other site 710685009157 NAD binding site [chemical binding]; other site 710685009158 catalytic residues [active] 710685009159 Proline dehydrogenase; Region: Pro_dh; cl03282 710685009160 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710685009161 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710685009162 dimer interface [polypeptide binding]; other site 710685009163 active site 710685009164 ADP-ribose binding site [chemical binding]; other site 710685009165 nudix motif; other site 710685009166 metal binding site [ion binding]; metal-binding site 710685009167 acyl-CoA synthetase; Validated; Region: PRK07787 710685009168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685009169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685009170 acyl-activating enzyme (AAE) consensus motif; other site 710685009171 acyl-activating enzyme (AAE) consensus motif; other site 710685009172 AMP binding site [chemical binding]; other site 710685009173 active site 710685009174 CoA binding site [chemical binding]; other site 710685009175 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710685009176 active site 710685009177 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 710685009178 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 710685009179 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 710685009180 putative trimer interface [polypeptide binding]; other site 710685009181 putative CoA binding site [chemical binding]; other site 710685009182 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 710685009183 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 710685009184 metal binding site [ion binding]; metal-binding site 710685009185 putative dimer interface [polypeptide binding]; other site 710685009186 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710685009187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685009188 Walker A/P-loop; other site 710685009189 ATP binding site [chemical binding]; other site 710685009190 Q-loop/lid; other site 710685009191 ABC transporter signature motif; other site 710685009192 Walker B; other site 710685009193 D-loop; other site 710685009194 H-loop/switch region; other site 710685009195 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685009196 hypothetical protein; Provisional; Region: PHA02690 710685009197 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 710685009198 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 710685009199 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 710685009200 acyl-activating enzyme (AAE) consensus motif; other site 710685009201 putative AMP binding site [chemical binding]; other site 710685009202 putative active site [active] 710685009203 putative CoA binding site [chemical binding]; other site 710685009204 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710685009205 dihydropteroate synthase; Region: DHPS; TIGR01496 710685009206 substrate binding pocket [chemical binding]; other site 710685009207 dimer interface [polypeptide binding]; other site 710685009208 inhibitor binding site; inhibition site 710685009209 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 710685009210 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710685009211 DivIVA domain; Region: DivI1A_domain; TIGR03544 710685009212 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 710685009213 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 710685009214 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 710685009215 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685009216 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 710685009217 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 710685009218 ligand binding site; other site 710685009219 oligomer interface; other site 710685009220 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 710685009221 sulfate 1 binding site; other site 710685009222 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 710685009223 Winged helix-turn helix; Region: HTH_29; pfam13551 710685009224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710685009225 Integrase core domain; Region: rve; pfam00665 710685009226 Integrase core domain; Region: rve_3; pfam13683 710685009227 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685009228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685009229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685009230 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685009231 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710685009232 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710685009233 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710685009234 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685009235 Walker A/P-loop; other site 710685009236 ATP binding site [chemical binding]; other site 710685009237 Q-loop/lid; other site 710685009238 ABC transporter signature motif; other site 710685009239 Walker B; other site 710685009240 D-loop; other site 710685009241 H-loop/switch region; other site 710685009242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009244 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710685009245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685009246 S-adenosylmethionine binding site [chemical binding]; other site 710685009247 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 710685009248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685009249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685009250 DNA binding residues [nucleotide binding] 710685009251 Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347 710685009252 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685009253 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710685009254 protein binding site [polypeptide binding]; other site 710685009255 sec-independent translocase; Provisional; Region: PRK03100 710685009256 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710685009257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710685009258 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 710685009259 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710685009260 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710685009261 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710685009262 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 710685009263 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 710685009264 MgtE intracellular N domain; Region: MgtE_N; smart00924 710685009265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 710685009266 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710685009267 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710685009268 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710685009269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710685009270 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710685009271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710685009272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685009273 dimer interface [polypeptide binding]; other site 710685009274 conserved gate region; other site 710685009275 putative PBP binding loops; other site 710685009276 ABC-ATPase subunit interface; other site 710685009277 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710685009278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685009279 dimer interface [polypeptide binding]; other site 710685009280 conserved gate region; other site 710685009281 putative PBP binding loops; other site 710685009282 ABC-ATPase subunit interface; other site 710685009283 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710685009284 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710685009285 Walker A/P-loop; other site 710685009286 ATP binding site [chemical binding]; other site 710685009287 Q-loop/lid; other site 710685009288 ABC transporter signature motif; other site 710685009289 Walker B; other site 710685009290 D-loop; other site 710685009291 H-loop/switch region; other site 710685009292 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 710685009293 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710685009294 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710685009295 oligomer interface [polypeptide binding]; other site 710685009296 metal binding site [ion binding]; metal-binding site 710685009297 metal binding site [ion binding]; metal-binding site 710685009298 putative Cl binding site [ion binding]; other site 710685009299 basic sphincter; other site 710685009300 hydrophobic gate; other site 710685009301 periplasmic entrance; other site 710685009302 malate dehydrogenase; Provisional; Region: PRK05442 710685009303 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 710685009304 NAD(P) binding site [chemical binding]; other site 710685009305 dimer interface [polypeptide binding]; other site 710685009306 malate binding site [chemical binding]; other site 710685009307 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710685009308 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710685009309 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 710685009310 NAD(P) binding pocket [chemical binding]; other site 710685009311 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 710685009312 short chain dehydrogenase; Provisional; Region: PRK06181 710685009313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009314 NAD(P) binding site [chemical binding]; other site 710685009315 active site 710685009316 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 710685009317 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710685009318 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 710685009319 TPP-binding site [chemical binding]; other site 710685009320 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 710685009321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685009322 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 710685009323 putative substrate translocation pore; other site 710685009324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685009325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685009326 putative substrate translocation pore; other site 710685009327 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685009328 FAD binding domain; Region: FAD_binding_4; pfam01565 710685009329 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 710685009330 RNase_H superfamily; Region: RNase_H_2; pfam13482 710685009331 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710685009332 Part of AAA domain; Region: AAA_19; pfam13245 710685009333 AAA domain; Region: AAA_12; pfam13087 710685009334 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 710685009335 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 710685009336 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710685009337 ATP binding site [chemical binding]; other site 710685009338 Mg++ binding site [ion binding]; other site 710685009339 motif III; other site 710685009340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685009341 nucleotide binding region [chemical binding]; other site 710685009342 ATP-binding site [chemical binding]; other site 710685009343 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 710685009344 putative RNA binding site [nucleotide binding]; other site 710685009345 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 710685009346 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710685009347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009349 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685009350 FAD binding domain; Region: FAD_binding_4; pfam01565 710685009351 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710685009352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685009353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685009354 DNA binding residues [nucleotide binding] 710685009355 dimerization interface [polypeptide binding]; other site 710685009356 H+ Antiporter protein; Region: 2A0121; TIGR00900 710685009357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685009358 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 710685009359 Fe-S cluster binding site [ion binding]; other site 710685009360 DNA binding site [nucleotide binding] 710685009361 active site 710685009362 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710685009363 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685009364 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685009365 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 710685009366 HIT family signature motif; other site 710685009367 catalytic residue [active] 710685009368 amidase; Provisional; Region: PRK12470 710685009369 Amidase; Region: Amidase; pfam01425 710685009370 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 710685009371 putative active site [active] 710685009372 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685009373 cyclase homology domain; Region: CHD; cd07302 710685009374 nucleotidyl binding site; other site 710685009375 metal binding site [ion binding]; metal-binding site 710685009376 dimer interface [polypeptide binding]; other site 710685009377 Short C-terminal domain; Region: SHOCT; pfam09851 710685009378 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685009379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009380 NAD(P) binding site [chemical binding]; other site 710685009381 active site 710685009382 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685009383 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685009384 active site 710685009385 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710685009386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685009387 metal-binding site [ion binding] 710685009388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710685009389 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 710685009390 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710685009391 metal-binding site [ion binding] 710685009392 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 710685009393 putative active site [active] 710685009394 dimerization interface [polypeptide binding]; other site 710685009395 putative tRNAtyr binding site [nucleotide binding]; other site 710685009396 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685009397 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 710685009398 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685009399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685009400 molybdopterin cofactor binding site; other site 710685009401 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710685009402 molybdopterin cofactor binding site; other site 710685009403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685009404 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 710685009405 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710685009406 Walker A/P-loop; other site 710685009407 ATP binding site [chemical binding]; other site 710685009408 Q-loop/lid; other site 710685009409 ABC transporter signature motif; other site 710685009410 Walker B; other site 710685009411 D-loop; other site 710685009412 H-loop/switch region; other site 710685009413 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710685009414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685009415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685009416 Walker A/P-loop; other site 710685009417 ATP binding site [chemical binding]; other site 710685009418 Q-loop/lid; other site 710685009419 ABC transporter signature motif; other site 710685009420 Walker B; other site 710685009421 D-loop; other site 710685009422 H-loop/switch region; other site 710685009423 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710685009424 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710685009425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685009426 catalytic core [active] 710685009427 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 710685009428 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 710685009429 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 710685009430 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 710685009431 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 710685009432 active site 710685009433 metal binding site [ion binding]; metal-binding site 710685009434 DNA binding site [nucleotide binding] 710685009435 P-loop containing region of AAA domain; Region: AAA_29; cl17516 710685009436 choline dehydrogenase; Validated; Region: PRK02106 710685009437 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710685009438 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 710685009439 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 710685009440 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710685009441 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710685009442 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 710685009443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710685009444 Walker A/P-loop; other site 710685009445 ATP binding site [chemical binding]; other site 710685009446 Q-loop/lid; other site 710685009447 ABC transporter signature motif; other site 710685009448 Walker B; other site 710685009449 D-loop; other site 710685009450 H-loop/switch region; other site 710685009451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710685009452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710685009453 Walker A/P-loop; other site 710685009454 ATP binding site [chemical binding]; other site 710685009455 Q-loop/lid; other site 710685009456 ABC transporter signature motif; other site 710685009457 Walker B; other site 710685009458 D-loop; other site 710685009459 H-loop/switch region; other site 710685009460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710685009461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710685009462 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 710685009463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685009464 dimer interface [polypeptide binding]; other site 710685009465 conserved gate region; other site 710685009466 putative PBP binding loops; other site 710685009467 ABC-ATPase subunit interface; other site 710685009468 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 710685009469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685009470 dimer interface [polypeptide binding]; other site 710685009471 conserved gate region; other site 710685009472 putative PBP binding loops; other site 710685009473 ABC-ATPase subunit interface; other site 710685009474 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685009475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685009476 active site 710685009477 phosphorylation site [posttranslational modification] 710685009478 intermolecular recognition site; other site 710685009479 dimerization interface [polypeptide binding]; other site 710685009480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685009481 DNA binding site [nucleotide binding] 710685009482 HAMP domain; Region: HAMP; pfam00672 710685009483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685009484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685009485 dimer interface [polypeptide binding]; other site 710685009486 phosphorylation site [posttranslational modification] 710685009487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685009488 ATP binding site [chemical binding]; other site 710685009489 Mg2+ binding site [ion binding]; other site 710685009490 G-X-G motif; other site 710685009491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685009492 active site 710685009493 GtrA-like protein; Region: GtrA; pfam04138 710685009494 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710685009495 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 710685009496 active site clefts [active] 710685009497 zinc binding site [ion binding]; other site 710685009498 dimer interface [polypeptide binding]; other site 710685009499 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 710685009500 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710685009501 Active Sites [active] 710685009502 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 710685009503 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 710685009504 CysD dimerization site [polypeptide binding]; other site 710685009505 G1 box; other site 710685009506 putative GEF interaction site [polypeptide binding]; other site 710685009507 GTP/Mg2+ binding site [chemical binding]; other site 710685009508 Switch I region; other site 710685009509 G2 box; other site 710685009510 G3 box; other site 710685009511 Switch II region; other site 710685009512 G4 box; other site 710685009513 G5 box; other site 710685009514 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 710685009515 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 710685009516 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 710685009517 ligand-binding site [chemical binding]; other site 710685009518 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710685009519 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710685009520 active site 710685009521 Rrf2 family protein; Region: rrf2_super; TIGR00738 710685009522 Transcriptional regulator; Region: Rrf2; pfam02082 710685009523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009524 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685009525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685009526 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685009527 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685009528 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 710685009529 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685009530 metal binding site [ion binding]; metal-binding site 710685009531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710685009532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710685009533 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685009534 Nitronate monooxygenase; Region: NMO; pfam03060 710685009535 FMN binding site [chemical binding]; other site 710685009536 substrate binding site [chemical binding]; other site 710685009537 putative catalytic residue [active] 710685009538 probable polyamine oxidase; Region: PLN02268 710685009539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685009540 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710685009541 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685009542 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685009543 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 710685009544 putative dimer interface [polypeptide binding]; other site 710685009545 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685009546 ligand binding site [chemical binding]; other site 710685009547 Zn binding site [ion binding]; other site 710685009548 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685009549 short chain dehydrogenase; Provisional; Region: PRK06197 710685009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009551 NAD(P) binding site [chemical binding]; other site 710685009552 active site 710685009553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009555 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685009556 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685009557 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710685009558 nucleophilic elbow; other site 710685009559 catalytic triad; other site 710685009560 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685009561 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 710685009562 MarC family integral membrane protein; Region: MarC; cl00919 710685009563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685009564 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710685009565 NAD(P) binding site [chemical binding]; other site 710685009566 Isochorismatase family; Region: Isochorismatase; pfam00857 710685009567 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 710685009568 catalytic triad [active] 710685009569 conserved cis-peptide bond; other site 710685009570 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 710685009571 Peptidase family M48; Region: Peptidase_M48; cl12018 710685009572 Isochorismatase family; Region: Isochorismatase; pfam00857 710685009573 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 710685009574 catalytic triad [active] 710685009575 conserved cis-peptide bond; other site 710685009576 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 710685009577 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 710685009578 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 710685009579 nucleotide binding site/active site [active] 710685009580 HIT family signature motif; other site 710685009581 catalytic residue [active] 710685009582 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 710685009583 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 710685009584 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710685009585 active site 710685009586 HIGH motif; other site 710685009587 KMSK motif region; other site 710685009588 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 710685009589 tRNA binding surface [nucleotide binding]; other site 710685009590 anticodon binding site; other site 710685009591 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710685009592 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710685009593 active site 710685009594 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710685009595 substrate binding site [chemical binding]; other site 710685009596 catalytic residues [active] 710685009597 dimer interface [polypeptide binding]; other site 710685009598 homoserine dehydrogenase; Provisional; Region: PRK06349 710685009599 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710685009600 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 710685009601 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 710685009602 threonine synthase; Reviewed; Region: PRK06721 710685009603 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 710685009604 homodimer interface [polypeptide binding]; other site 710685009605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685009606 catalytic residue [active] 710685009607 homoserine kinase; Provisional; Region: PRK01212 710685009608 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 710685009609 transcription termination factor Rho; Provisional; Region: PRK12608 710685009610 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710685009611 RNA binding site [nucleotide binding]; other site 710685009612 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 710685009613 multimer interface [polypeptide binding]; other site 710685009614 Walker A motif; other site 710685009615 ATP binding site [chemical binding]; other site 710685009616 Walker B motif; other site 710685009617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009619 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 710685009620 peptide chain release factor 1; Region: prfA; TIGR00019 710685009621 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710685009622 RF-1 domain; Region: RF-1; pfam00472 710685009623 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 710685009624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685009625 S-adenosylmethionine binding site [chemical binding]; other site 710685009626 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 710685009627 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 710685009628 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 710685009629 Mg++ binding site [ion binding]; other site 710685009630 putative catalytic motif [active] 710685009631 substrate binding site [chemical binding]; other site 710685009632 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 710685009633 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 710685009634 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 710685009635 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710685009636 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 710685009637 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 710685009638 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 710685009639 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 710685009640 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710685009641 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710685009642 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710685009643 beta subunit interaction interface [polypeptide binding]; other site 710685009644 Walker A motif; other site 710685009645 ATP binding site [chemical binding]; other site 710685009646 Walker B motif; other site 710685009647 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710685009648 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 710685009649 core domain interface [polypeptide binding]; other site 710685009650 delta subunit interface [polypeptide binding]; other site 710685009651 epsilon subunit interface [polypeptide binding]; other site 710685009652 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710685009653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710685009654 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710685009655 alpha subunit interaction interface [polypeptide binding]; other site 710685009656 Walker A motif; other site 710685009657 ATP binding site [chemical binding]; other site 710685009658 Walker B motif; other site 710685009659 inhibitor binding site; inhibition site 710685009660 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710685009661 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 710685009662 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 710685009663 gamma subunit interface [polypeptide binding]; other site 710685009664 epsilon subunit interface [polypeptide binding]; other site 710685009665 LBP interface [polypeptide binding]; other site 710685009666 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 710685009667 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 710685009668 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 710685009669 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 710685009670 hinge; other site 710685009671 active site 710685009672 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710685009673 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 710685009674 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710685009675 DNA binding site [nucleotide binding] 710685009676 active site 710685009677 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 710685009678 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 710685009679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685009680 AlkA N-terminal domain; Region: AlkA_N; pfam06029 710685009681 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710685009682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710685009683 minor groove reading motif; other site 710685009684 helix-hairpin-helix signature motif; other site 710685009685 substrate binding pocket [chemical binding]; other site 710685009686 active site 710685009687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685009688 dimerization interface [polypeptide binding]; other site 710685009689 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685009690 cyclase homology domain; Region: CHD; cd07302 710685009691 nucleotidyl binding site; other site 710685009692 metal binding site [ion binding]; metal-binding site 710685009693 dimer interface [polypeptide binding]; other site 710685009694 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 710685009695 hypothetical protein; Provisional; Region: PRK03298 710685009696 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710685009697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685009698 dimer interface [polypeptide binding]; other site 710685009699 substrate binding site [chemical binding]; other site 710685009700 metal binding site [ion binding]; metal-binding site 710685009701 putative acyltransferase; Provisional; Region: PRK05790 710685009702 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685009703 dimer interface [polypeptide binding]; other site 710685009704 active site 710685009705 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710685009706 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 710685009707 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685009708 glycogen branching enzyme; Provisional; Region: PRK05402 710685009709 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 710685009710 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 710685009711 active site 710685009712 catalytic site [active] 710685009713 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 710685009714 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 710685009715 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 710685009716 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710685009717 active site 710685009718 homodimer interface [polypeptide binding]; other site 710685009719 catalytic site [active] 710685009720 acceptor binding site [chemical binding]; other site 710685009721 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 710685009722 putative homodimer interface [polypeptide binding]; other site 710685009723 putative active site pocket [active] 710685009724 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 710685009725 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 710685009726 MspA; Region: MspA; pfam09203 710685009727 Predicted metalloprotease [General function prediction only]; Region: COG2321 710685009728 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710685009729 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 710685009730 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 710685009731 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 710685009732 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 710685009733 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 710685009734 active site 710685009735 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 710685009736 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 710685009737 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 710685009738 putative active site pocket [active] 710685009739 cleavage site 710685009740 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 710685009741 MPN+ (JAMM) motif; other site 710685009742 Zinc-binding site [ion binding]; other site 710685009743 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 710685009744 MoaE interaction surface [polypeptide binding]; other site 710685009745 MoeB interaction surface [polypeptide binding]; other site 710685009746 thiocarboxylated glycine; other site 710685009747 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710685009748 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710685009749 dimer interface [polypeptide binding]; other site 710685009750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685009751 catalytic residue [active] 710685009752 Rhomboid family; Region: Rhomboid; pfam01694 710685009753 glutamate racemase; Provisional; Region: PRK00865 710685009754 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 710685009755 ribonuclease PH; Reviewed; Region: rph; PRK00173 710685009756 Ribonuclease PH; Region: RNase_PH_bact; cd11362 710685009757 hexamer interface [polypeptide binding]; other site 710685009758 active site 710685009759 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 710685009760 active site 710685009761 dimerization interface [polypeptide binding]; other site 710685009762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685009763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009765 haloalkane dehalogenase; Provisional; Region: PRK00870 710685009766 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710685009767 Glucitol operon activator protein (GutM); Region: GutM; cl01890 710685009768 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 710685009769 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710685009770 Amidase; Region: Amidase; pfam01425 710685009771 short chain dehydrogenase; Provisional; Region: PRK06500 710685009772 classical (c) SDRs; Region: SDR_c; cd05233 710685009773 NAD(P) binding site [chemical binding]; other site 710685009774 active site 710685009775 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710685009776 MarR family; Region: MarR_2; pfam12802 710685009777 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710685009778 putative hydrophobic ligand binding site [chemical binding]; other site 710685009779 protein interface [polypeptide binding]; other site 710685009780 gate; other site 710685009781 Transcription factor WhiB; Region: Whib; pfam02467 710685009782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009784 Cupin domain; Region: Cupin_2; cl17218 710685009785 Helix-turn-helix domain; Region: HTH_18; pfam12833 710685009786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685009787 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685009788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685009789 metabolite-proton symporter; Region: 2A0106; TIGR00883 710685009790 putative substrate translocation pore; other site 710685009791 hypothetical protein; Provisional; Region: PRK05463 710685009792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685009793 dimerization interface [polypeptide binding]; other site 710685009794 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685009795 cyclase homology domain; Region: CHD; cd07302 710685009796 nucleotidyl binding site; other site 710685009797 metal binding site [ion binding]; metal-binding site 710685009798 dimer interface [polypeptide binding]; other site 710685009799 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685009800 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685009801 acyl-activating enzyme (AAE) consensus motif; other site 710685009802 putative AMP binding site [chemical binding]; other site 710685009803 putative active site [active] 710685009804 putative CoA binding site [chemical binding]; other site 710685009805 short chain dehydrogenase; Provisional; Region: PRK08278 710685009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009807 NAD(P) binding site [chemical binding]; other site 710685009808 active site 710685009809 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 710685009810 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710685009811 B12 binding site [chemical binding]; other site 710685009812 cobalt ligand [ion binding]; other site 710685009813 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685009814 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685009815 putative CoA-transferase; Provisional; Region: PRK11430 710685009816 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685009817 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685009818 catalytic loop [active] 710685009819 iron binding site [ion binding]; other site 710685009820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685009821 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685009822 acyl-activating enzyme (AAE) consensus motif; other site 710685009823 AMP binding site [chemical binding]; other site 710685009824 active site 710685009825 CoA binding site [chemical binding]; other site 710685009826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009830 active site 710685009831 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685009832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685009833 substrate binding site [chemical binding]; other site 710685009834 oxyanion hole (OAH) forming residues; other site 710685009835 trimer interface [polypeptide binding]; other site 710685009836 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685009837 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685009838 Integrase core domain; Region: rve; pfam00665 710685009839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685009840 enoyl-CoA hydratase; Provisional; Region: PRK12478 710685009841 substrate binding site [chemical binding]; other site 710685009842 oxyanion hole (OAH) forming residues; other site 710685009843 trimer interface [polypeptide binding]; other site 710685009844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009845 NAD(P) binding site [chemical binding]; other site 710685009846 active site 710685009847 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 710685009848 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710685009849 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685009850 G1 box; other site 710685009851 GTP/Mg2+ binding site [chemical binding]; other site 710685009852 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685009853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009854 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 710685009855 Subunit I/III interface [polypeptide binding]; other site 710685009856 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 710685009857 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685009858 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685009859 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685009860 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685009861 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685009862 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685009863 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 710685009864 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685009865 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 710685009866 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710685009867 putative active site [active] 710685009868 Fe(II) binding site [ion binding]; other site 710685009869 putative dimer interface [polypeptide binding]; other site 710685009870 putative tetramer interface [polypeptide binding]; other site 710685009871 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 710685009872 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685009873 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710685009874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685009875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009876 NAD(P) binding site [chemical binding]; other site 710685009877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009878 active site 710685009879 Putative cyclase; Region: Cyclase; pfam04199 710685009880 Predicted flavoprotein [General function prediction only]; Region: COG0431 710685009881 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710685009882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685009883 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685009884 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685009885 classical (c) SDRs; Region: SDR_c; cd05233 710685009886 NAD(P) binding site [chemical binding]; other site 710685009887 active site 710685009888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685009889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009890 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685009891 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685009892 Cytochrome P450; Region: p450; cl12078 710685009893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685009894 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685009895 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710685009896 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710685009897 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710685009898 active site 710685009899 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710685009900 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710685009901 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710685009902 active site 710685009903 enoyl-CoA hydratase; Provisional; Region: PRK12478 710685009904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685009905 substrate binding site [chemical binding]; other site 710685009906 oxyanion hole (OAH) forming residues; other site 710685009907 trimer interface [polypeptide binding]; other site 710685009908 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685009909 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685009910 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685009911 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685009912 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685009913 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685009914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009915 NAD(P) binding site [chemical binding]; other site 710685009916 active site 710685009917 short chain dehydrogenase; Provisional; Region: PRK05876 710685009918 classical (c) SDRs; Region: SDR_c; cd05233 710685009919 NAD(P) binding site [chemical binding]; other site 710685009920 active site 710685009921 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685009922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009924 active site 710685009925 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685009926 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685009927 putative acyl-acceptor binding pocket; other site 710685009928 acyl-CoA synthetase; Provisional; Region: PRK13382 710685009929 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685009930 acyl-activating enzyme (AAE) consensus motif; other site 710685009931 putative AMP binding site [chemical binding]; other site 710685009932 putative active site [active] 710685009933 putative CoA binding site [chemical binding]; other site 710685009934 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685009935 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685009936 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685009937 Ecdysteroid kinase; Region: EcKinase; cl17738 710685009938 Phosphotransferase enzyme family; Region: APH; pfam01636 710685009939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009941 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685009942 classical (c) SDRs; Region: SDR_c; cd05233 710685009943 NAD(P) binding site [chemical binding]; other site 710685009944 active site 710685009945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685009946 Cytochrome P450; Region: p450; cl12078 710685009947 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685009948 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685009949 active site 710685009950 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685009951 catalytic triad [active] 710685009952 dimer interface [polypeptide binding]; other site 710685009953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685009954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685009955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009957 active site 710685009958 enoyl-CoA hydratase; Provisional; Region: PRK08290 710685009959 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685009960 substrate binding site [chemical binding]; other site 710685009961 oxyanion hole (OAH) forming residues; other site 710685009962 trimer interface [polypeptide binding]; other site 710685009963 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710685009964 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685009965 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685009966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009967 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710685009968 NAD(P) binding site [chemical binding]; other site 710685009969 active site 710685009970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009974 active site 710685009975 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685009976 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710685009977 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685009978 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710685009979 active site 710685009980 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685009981 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685009982 [2Fe-2S] cluster binding site [ion binding]; other site 710685009983 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710685009984 alpha subunit interface [polypeptide binding]; other site 710685009985 active site 710685009986 substrate binding site [chemical binding]; other site 710685009987 Fe binding site [ion binding]; other site 710685009988 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685009989 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685009990 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685009991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685009992 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685009993 active site 710685009994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685009995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685009996 NAD(P) binding site [chemical binding]; other site 710685009997 active site 710685009998 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685009999 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685010000 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685010001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010002 substrate binding site [chemical binding]; other site 710685010003 oxyanion hole (OAH) forming residues; other site 710685010004 trimer interface [polypeptide binding]; other site 710685010005 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710685010006 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685010007 dimer interface [polypeptide binding]; other site 710685010008 active site 710685010009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010011 active site 710685010012 TetR family transcriptional regulator; Provisional; Region: PRK14996 710685010013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010014 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710685010015 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710685010016 NAD(P) binding site [chemical binding]; other site 710685010017 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685010018 Phosphotransferase enzyme family; Region: APH; pfam01636 710685010019 putative active site [active] 710685010020 putative substrate binding site [chemical binding]; other site 710685010021 ATP binding site [chemical binding]; other site 710685010022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010024 active site 710685010025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685010026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685010027 NAD(P) binding site [chemical binding]; other site 710685010028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010030 classical (c) SDRs; Region: SDR_c; cd05233 710685010031 NAD(P) binding site [chemical binding]; other site 710685010032 active site 710685010033 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685010034 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685010035 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685010036 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685010037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685010038 NAD(P) binding site [chemical binding]; other site 710685010039 active site 710685010040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010042 active site 710685010043 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710685010044 metal ion-dependent adhesion site (MIDAS); other site 710685010045 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 710685010046 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 710685010047 Walker A motif; other site 710685010048 ATP binding site [chemical binding]; other site 710685010049 Walker B motif; other site 710685010050 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710685010051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010053 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685010054 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685010055 [2Fe-2S] cluster binding site [ion binding]; other site 710685010056 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710685010057 alpha subunit interface [polypeptide binding]; other site 710685010058 active site 710685010059 substrate binding site [chemical binding]; other site 710685010060 Fe binding site [ion binding]; other site 710685010061 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710685010062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685010063 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710685010064 active site 710685010065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685010066 MarR family; Region: MarR_2; pfam12802 710685010067 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685010068 catalytic loop [active] 710685010069 iron binding site [ion binding]; other site 710685010070 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685010071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685010072 NAD(P) binding site [chemical binding]; other site 710685010073 active site 710685010074 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685010075 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685010076 [2Fe-2S] cluster binding site [ion binding]; other site 710685010077 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710685010078 alpha subunit interface [polypeptide binding]; other site 710685010079 active site 710685010080 substrate binding site [chemical binding]; other site 710685010081 Fe binding site [ion binding]; other site 710685010082 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710685010083 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710685010084 substrate binding pocket [chemical binding]; other site 710685010085 active site 710685010086 iron coordination sites [ion binding]; other site 710685010087 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010088 Cytochrome P450; Region: p450; cl12078 710685010089 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685010090 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685010091 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710685010092 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685010093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685010094 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010095 Cytochrome P450; Region: p450; cl12078 710685010096 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685010097 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685010098 Cytochrome P450; Region: p450; cl12078 710685010099 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010100 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710685010101 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685010102 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685010103 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710685010104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685010105 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685010106 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685010107 lipid-transfer protein; Provisional; Region: PRK07855 710685010108 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685010109 active site 710685010110 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685010111 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710685010112 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710685010113 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685010114 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685010115 iron-sulfur cluster [ion binding]; other site 710685010116 [2Fe-2S] cluster binding site [ion binding]; other site 710685010117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685010118 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685010119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010120 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685010121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010124 active site 710685010125 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685010126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010127 substrate binding site [chemical binding]; other site 710685010128 oxyanion hole (OAH) forming residues; other site 710685010129 trimer interface [polypeptide binding]; other site 710685010130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010132 active site 710685010133 short chain dehydrogenase; Provisional; Region: PRK08278 710685010134 classical (c) SDRs; Region: SDR_c; cd05233 710685010135 NAD(P) binding site [chemical binding]; other site 710685010136 active site 710685010137 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685010138 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685010139 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710685010140 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685010141 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010142 Cytochrome P450; Region: p450; cl12078 710685010143 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 710685010144 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685010145 classical (c) SDRs; Region: SDR_c; cd05233 710685010146 NAD(P) binding site [chemical binding]; other site 710685010147 active site 710685010148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685010149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685010150 NAD(P) binding site [chemical binding]; other site 710685010151 active site 710685010152 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710685010153 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685010154 NAD binding site [chemical binding]; other site 710685010155 catalytic residues [active] 710685010156 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685010157 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685010158 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685010159 Permease; Region: Permease; pfam02405 710685010160 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685010161 Permease; Region: Permease; pfam02405 710685010162 mce related protein; Region: MCE; pfam02470 710685010163 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685010164 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010165 mce related protein; Region: MCE; pfam02470 710685010166 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710685010167 mce related protein; Region: MCE; pfam02470 710685010168 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685010169 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010170 mce related protein; Region: MCE; pfam02470 710685010171 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 710685010172 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010173 mce related protein; Region: MCE; pfam02470 710685010174 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685010175 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010176 mce related protein; Region: MCE; pfam02470 710685010177 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710685010178 nudix motif; other site 710685010179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010180 Cytochrome P450; Region: p450; cl12078 710685010181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010183 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 710685010184 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710685010185 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685010186 active site 710685010187 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685010188 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685010189 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685010190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685010191 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685010192 Uncharacterized conserved protein [Function unknown]; Region: COG4278 710685010193 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685010194 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685010195 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710685010196 dimer interface [polypeptide binding]; other site 710685010197 substrate binding site [chemical binding]; other site 710685010198 metal binding site [ion binding]; metal-binding site 710685010199 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685010200 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010201 substrate binding site [chemical binding]; other site 710685010202 oxyanion hole (OAH) forming residues; other site 710685010203 trimer interface [polypeptide binding]; other site 710685010204 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 710685010205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685010206 acyl-activating enzyme (AAE) consensus motif; other site 710685010207 AMP binding site [chemical binding]; other site 710685010208 active site 710685010209 CoA binding site [chemical binding]; other site 710685010210 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685010211 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710685010212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685010213 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710685010214 acyl-activating enzyme (AAE) consensus motif; other site 710685010215 acyl-activating enzyme (AAE) consensus motif; other site 710685010216 putative AMP binding site [chemical binding]; other site 710685010217 putative active site [active] 710685010218 putative CoA binding site [chemical binding]; other site 710685010219 hypothetical protein; Provisional; Region: PRK05415 710685010220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710685010221 active site 710685010222 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710685010223 substrate binding site; other site 710685010224 dimer interface; other site 710685010225 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685010226 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 710685010227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685010228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685010229 putative substrate translocation pore; other site 710685010230 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710685010231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685010232 DNA binding residues [nucleotide binding] 710685010233 putative dimer interface [polypeptide binding]; other site 710685010234 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710685010235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685010236 dimer interface [polypeptide binding]; other site 710685010237 conserved gate region; other site 710685010238 putative PBP binding loops; other site 710685010239 ABC-ATPase subunit interface; other site 710685010240 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710685010241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685010242 dimer interface [polypeptide binding]; other site 710685010243 conserved gate region; other site 710685010244 putative PBP binding loops; other site 710685010245 ABC-ATPase subunit interface; other site 710685010246 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 710685010247 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710685010248 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710685010249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685010250 Walker A/P-loop; other site 710685010251 ATP binding site [chemical binding]; other site 710685010252 Q-loop/lid; other site 710685010253 ABC transporter signature motif; other site 710685010254 Walker B; other site 710685010255 D-loop; other site 710685010256 H-loop/switch region; other site 710685010257 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710685010258 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710685010259 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 710685010260 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685010261 phosphate binding site [ion binding]; other site 710685010262 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 710685010263 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 710685010264 putative active site [active] 710685010265 putative catalytic site [active] 710685010266 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710685010267 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710685010268 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 710685010269 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 710685010270 putative NAD(P) binding site [chemical binding]; other site 710685010271 active site 710685010272 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 710685010273 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710685010274 active site 710685010275 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 710685010276 hypothetical protein; Provisional; Region: PRK07907 710685010277 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 710685010278 active site 710685010279 metal binding site [ion binding]; metal-binding site 710685010280 dimer interface [polypeptide binding]; other site 710685010281 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710685010282 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685010283 catalytic triad [active] 710685010284 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710685010285 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685010286 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710685010287 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710685010288 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685010289 Predicted membrane protein [Function unknown]; Region: COG2860 710685010290 UPF0126 domain; Region: UPF0126; pfam03458 710685010291 UPF0126 domain; Region: UPF0126; pfam03458 710685010292 murein hydrolase B; Provisional; Region: PRK10760; cl17906 710685010293 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685010294 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710685010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685010296 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685010297 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 710685010298 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 710685010299 catalytic site [active] 710685010300 putative active site [active] 710685010301 putative substrate binding site [chemical binding]; other site 710685010302 dimer interface [polypeptide binding]; other site 710685010303 Domain of unknown function DUF87; Region: DUF87; pfam01935 710685010304 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 710685010305 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685010306 classical (c) SDRs; Region: SDR_c; cd05233 710685010307 NAD(P) binding site [chemical binding]; other site 710685010308 active site 710685010309 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 710685010310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685010311 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685010312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010314 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 710685010315 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685010316 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685010317 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710685010318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685010319 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710685010320 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 710685010321 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685010322 carboxyltransferase (CT) interaction site; other site 710685010323 biotinylation site [posttranslational modification]; other site 710685010324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010325 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010326 active site 710685010327 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710685010328 putative active site [active] 710685010329 putative catalytic site [active] 710685010330 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710685010331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685010332 MarR family; Region: MarR; pfam01047 710685010333 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710685010334 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710685010335 tetramer interface [polypeptide binding]; other site 710685010336 TPP-binding site [chemical binding]; other site 710685010337 heterodimer interface [polypeptide binding]; other site 710685010338 phosphorylation loop region [posttranslational modification] 710685010339 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710685010340 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710685010341 alpha subunit interface [polypeptide binding]; other site 710685010342 TPP binding site [chemical binding]; other site 710685010343 heterodimer interface [polypeptide binding]; other site 710685010344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685010345 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710685010346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710685010347 E3 interaction surface; other site 710685010348 lipoyl attachment site [posttranslational modification]; other site 710685010349 e3 binding domain; Region: E3_binding; pfam02817 710685010350 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710685010351 enoyl-CoA hydratase; Provisional; Region: PRK05870 710685010352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010353 substrate binding site [chemical binding]; other site 710685010354 oxyanion hole (OAH) forming residues; other site 710685010355 trimer interface [polypeptide binding]; other site 710685010356 PE-PPE domain; Region: PE-PPE; pfam08237 710685010357 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685010358 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685010359 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710685010360 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 710685010361 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685010362 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685010363 putative acyl-acceptor binding pocket; other site 710685010364 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 710685010365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 710685010366 putative acyl-acceptor binding pocket; other site 710685010367 Copper resistance protein D; Region: CopD; pfam05425 710685010368 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710685010369 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710685010370 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710685010371 dimer interface [polypeptide binding]; other site 710685010372 ssDNA binding site [nucleotide binding]; other site 710685010373 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710685010374 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 710685010375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685010376 Walker A/P-loop; other site 710685010377 ATP binding site [chemical binding]; other site 710685010378 Q-loop/lid; other site 710685010379 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685010380 ABC transporter; Region: ABC_tran_2; pfam12848 710685010381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685010382 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 710685010383 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710685010384 active site 710685010385 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685010386 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685010387 Integrase core domain; Region: rve; pfam00665 710685010388 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 710685010389 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 710685010390 active site 710685010391 catalytic site [active] 710685010392 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710685010393 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710685010394 apolar tunnel; other site 710685010395 heme binding site [chemical binding]; other site 710685010396 dimerization interface [polypeptide binding]; other site 710685010397 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710685010398 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685010399 active site 710685010400 Repair protein; Region: Repair_PSII; cl01535 710685010401 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685010402 active site 710685010403 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 710685010404 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 710685010405 Zn binding site [ion binding]; other site 710685010406 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685010407 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710685010408 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710685010409 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 710685010410 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710685010411 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 710685010412 putative DNA binding site [nucleotide binding]; other site 710685010413 catalytic residue [active] 710685010414 putative H2TH interface [polypeptide binding]; other site 710685010415 putative catalytic residues [active] 710685010416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710685010417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710685010418 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685010419 GAF domain; Region: GAF; pfam01590 710685010420 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685010421 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710685010422 trigger factor; Provisional; Region: tig; PRK01490 710685010423 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710685010424 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710685010425 Clp protease; Region: CLP_protease; pfam00574 710685010426 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710685010427 oligomer interface [polypeptide binding]; other site 710685010428 active site residues [active] 710685010429 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 710685010430 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710685010431 oligomer interface [polypeptide binding]; other site 710685010432 active site residues [active] 710685010433 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 710685010434 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 710685010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685010436 Walker A motif; other site 710685010437 ATP binding site [chemical binding]; other site 710685010438 Walker B motif; other site 710685010439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 710685010440 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685010441 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685010442 active site 710685010443 TDP-binding site; other site 710685010444 acceptor substrate-binding pocket; other site 710685010445 homodimer interface [polypeptide binding]; other site 710685010446 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685010447 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 710685010448 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 710685010449 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 710685010450 putative molybdopterin cofactor binding site [chemical binding]; other site 710685010451 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 710685010452 putative molybdopterin cofactor binding site; other site 710685010453 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685010454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685010455 active site 710685010456 Winged helix-turn helix; Region: HTH_29; pfam13551 710685010457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710685010458 Integrase core domain; Region: rve; pfam00665 710685010459 Integrase core domain; Region: rve_3; pfam13683 710685010460 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 710685010461 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 710685010462 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685010463 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710685010464 putative homotetramer interface [polypeptide binding]; other site 710685010465 putative homodimer interface [polypeptide binding]; other site 710685010466 putative allosteric switch controlling residues; other site 710685010467 putative metal binding site [ion binding]; other site 710685010468 putative homodimer-homodimer interface [polypeptide binding]; other site 710685010469 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710685010470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010471 active site residue [active] 710685010472 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 710685010473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685010474 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010475 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010476 active site residue [active] 710685010477 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710685010478 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710685010479 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685010480 catalytic residues [active] 710685010481 Domain of unknown function DUF302; Region: DUF302; pfam03625 710685010482 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710685010483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685010484 Rhodanese-like domain; Region: Rhodanese; pfam00581 710685010485 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010486 active site residue [active] 710685010487 hypothetical protein; Provisional; Region: PRK06062 710685010488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685010489 inhibitor-cofactor binding pocket; inhibition site 710685010490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685010491 catalytic residue [active] 710685010492 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710685010493 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710685010494 tetrameric interface [polypeptide binding]; other site 710685010495 NAD binding site [chemical binding]; other site 710685010496 catalytic residues [active] 710685010497 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710685010498 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710685010499 Metal-binding active site; metal-binding site 710685010500 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685010501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685010502 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710685010503 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710685010504 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 710685010505 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685010506 dimer interface [polypeptide binding]; other site 710685010507 PYR/PP interface [polypeptide binding]; other site 710685010508 TPP binding site [chemical binding]; other site 710685010509 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685010510 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 710685010511 TPP-binding site; other site 710685010512 KduI/IolB family; Region: KduI; pfam04962 710685010513 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710685010514 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 710685010515 substrate binding site [chemical binding]; other site 710685010516 ATP binding site [chemical binding]; other site 710685010517 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710685010518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685010519 DNA-binding site [nucleotide binding]; DNA binding site 710685010520 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710685010521 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 710685010522 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710685010523 DNA interaction; other site 710685010524 Metal-binding active site; metal-binding site 710685010525 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 710685010526 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 710685010527 putative ligand binding site [chemical binding]; other site 710685010528 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710685010529 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710685010530 TM-ABC transporter signature motif; other site 710685010531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710685010532 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710685010533 Walker A/P-loop; other site 710685010534 ATP binding site [chemical binding]; other site 710685010535 Q-loop/lid; other site 710685010536 ABC transporter signature motif; other site 710685010537 Walker B; other site 710685010538 D-loop; other site 710685010539 H-loop/switch region; other site 710685010540 AMP-binding domain protein; Validated; Region: PRK08315 710685010541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685010542 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710685010543 acyl-activating enzyme (AAE) consensus motif; other site 710685010544 putative AMP binding site [chemical binding]; other site 710685010545 putative active site [active] 710685010546 putative CoA binding site [chemical binding]; other site 710685010547 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010548 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685010549 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685010550 active site 710685010551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010552 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710685010553 FAD binding site [chemical binding]; other site 710685010554 substrate binding site [chemical binding]; other site 710685010555 catalytic base [active] 710685010556 enoyl-CoA hydratase; Provisional; Region: PRK08290 710685010557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010558 substrate binding site [chemical binding]; other site 710685010559 oxyanion hole (OAH) forming residues; other site 710685010560 trimer interface [polypeptide binding]; other site 710685010561 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685010562 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710685010563 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 710685010564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685010565 catalytic loop [active] 710685010566 iron binding site [ion binding]; other site 710685010567 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 710685010568 FAD binding pocket [chemical binding]; other site 710685010569 FAD binding motif [chemical binding]; other site 710685010570 phosphate binding motif [ion binding]; other site 710685010571 beta-alpha-beta structure motif; other site 710685010572 NAD binding pocket [chemical binding]; other site 710685010573 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710685010574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685010575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685010576 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685010577 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 710685010578 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710685010579 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 710685010580 dimerization interface [polypeptide binding]; other site 710685010581 active site 710685010582 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710685010583 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 710685010584 homodimer interface [polypeptide binding]; other site 710685010585 putative NAD(P) binding site [chemical binding]; other site 710685010586 active site 710685010587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010589 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 710685010590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685010591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685010592 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685010593 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685010594 Permease; Region: Permease; pfam02405 710685010595 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710685010596 Permease; Region: Permease; pfam02405 710685010597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010598 mce related protein; Region: MCE; pfam02470 710685010599 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685010600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010601 mce related protein; Region: MCE; pfam02470 710685010602 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010603 mce related protein; Region: MCE; pfam02470 710685010604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010605 mce related protein; Region: MCE; pfam02470 710685010606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010607 mce related protein; Region: MCE; pfam02470 710685010608 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710685010609 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710685010610 mce related protein; Region: MCE; pfam02470 710685010611 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710685010612 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710685010613 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685010614 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685010615 Cytochrome P450; Region: p450; cl12078 710685010616 GAF domain; Region: GAF; cl17456 710685010617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685010618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685010619 DNA binding residues [nucleotide binding] 710685010620 dimerization interface [polypeptide binding]; other site 710685010621 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685010622 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685010623 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710685010624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710685010625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685010626 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710685010627 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 710685010628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710685010629 DNA binding site [nucleotide binding] 710685010630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 710685010631 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 710685010632 putative ligand binding site [chemical binding]; other site 710685010633 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710685010634 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 710685010635 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710685010636 dimer interface [polypeptide binding]; other site 710685010637 PYR/PP interface [polypeptide binding]; other site 710685010638 TPP binding site [chemical binding]; other site 710685010639 substrate binding site [chemical binding]; other site 710685010640 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 710685010641 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 710685010642 TPP-binding site [chemical binding]; other site 710685010643 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 710685010644 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 710685010645 GTP binding site; other site 710685010646 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710685010647 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710685010648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685010649 hypothetical protein; Provisional; Region: PRK06847 710685010650 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685010651 CoenzymeA binding site [chemical binding]; other site 710685010652 subunit interaction site [polypeptide binding]; other site 710685010653 PHB binding site; other site 710685010654 Predicted transcriptional regulators [Transcription]; Region: COG1733 710685010655 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710685010656 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710685010657 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685010658 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710685010659 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 710685010660 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 710685010661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685010662 active site 710685010663 HIGH motif; other site 710685010664 nucleotide binding site [chemical binding]; other site 710685010665 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710685010666 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 710685010667 active site 710685010668 KMSKS motif; other site 710685010669 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710685010670 tRNA binding surface [nucleotide binding]; other site 710685010671 anticodon binding site; other site 710685010672 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 710685010673 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 710685010674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685010675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710685010676 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 710685010677 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 710685010678 active site 710685010679 multimer interface [polypeptide binding]; other site 710685010680 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 710685010681 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 710685010682 homodimer interface [polypeptide binding]; other site 710685010683 oligonucleotide binding site [chemical binding]; other site 710685010684 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 710685010685 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 710685010686 GTPase CgtA; Reviewed; Region: obgE; PRK12296 710685010687 GTP1/OBG; Region: GTP1_OBG; pfam01018 710685010688 Obg GTPase; Region: Obg; cd01898 710685010689 G1 box; other site 710685010690 GTP/Mg2+ binding site [chemical binding]; other site 710685010691 Switch I region; other site 710685010692 G2 box; other site 710685010693 G3 box; other site 710685010694 Switch II region; other site 710685010695 G4 box; other site 710685010696 G5 box; other site 710685010697 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 710685010698 gamma-glutamyl kinase; Provisional; Region: PRK05429 710685010699 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 710685010700 nucleotide binding site [chemical binding]; other site 710685010701 homotetrameric interface [polypeptide binding]; other site 710685010702 putative phosphate binding site [ion binding]; other site 710685010703 putative allosteric binding site; other site 710685010704 PUA domain; Region: PUA; pfam01472 710685010705 NAD-dependent deacetylase; Provisional; Region: PRK00481 710685010706 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 710685010707 Isochorismatase family; Region: Isochorismatase; pfam00857 710685010708 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710685010709 catalytic triad [active] 710685010710 conserved cis-peptide bond; other site 710685010711 NAD synthetase; Reviewed; Region: nadE; PRK02628 710685010712 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 710685010713 multimer interface [polypeptide binding]; other site 710685010714 active site 710685010715 catalytic triad [active] 710685010716 protein interface 1 [polypeptide binding]; other site 710685010717 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 710685010718 homodimer interface [polypeptide binding]; other site 710685010719 NAD binding pocket [chemical binding]; other site 710685010720 ATP binding pocket [chemical binding]; other site 710685010721 Mg binding site [ion binding]; other site 710685010722 active-site loop [active] 710685010723 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710685010724 Cation efflux family; Region: Cation_efflux; cl00316 710685010725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685010726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685010727 putative DNA binding site [nucleotide binding]; other site 710685010728 dimerization interface [polypeptide binding]; other site 710685010729 putative Zn2+ binding site [ion binding]; other site 710685010730 Winged helix-turn helix; Region: HTH_29; pfam13551 710685010731 Homeodomain-like domain; Region: HTH_23; pfam13384 710685010732 Homeodomain-like domain; Region: HTH_32; pfam13565 710685010733 putative transposase OrfB; Reviewed; Region: PHA02517 710685010734 Integrase core domain; Region: rve; pfam00665 710685010735 Integrase core domain; Region: rve_3; pfam13683 710685010736 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685010737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685010738 substrate binding site [chemical binding]; other site 710685010739 oxyanion hole (OAH) forming residues; other site 710685010740 trimer interface [polypeptide binding]; other site 710685010741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710685010742 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 710685010743 substrate binding site [chemical binding]; other site 710685010744 dimer interface [polypeptide binding]; other site 710685010745 ATP binding site [chemical binding]; other site 710685010746 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 710685010747 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 710685010748 putative catalytic cysteine [active] 710685010749 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710685010750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685010751 Walker A motif; other site 710685010752 ATP binding site [chemical binding]; other site 710685010753 Walker B motif; other site 710685010754 arginine finger; other site 710685010755 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710685010756 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710685010757 metal ion-dependent adhesion site (MIDAS); other site 710685010758 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 710685010759 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710685010760 active site 710685010761 (T/H)XGH motif; other site 710685010762 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 710685010763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685010764 catalytic core [active] 710685010765 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710685010766 active site 710685010767 catalytic triad [active] 710685010768 oxyanion hole [active] 710685010769 EDD domain protein, DegV family; Region: DegV; TIGR00762 710685010770 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710685010771 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685010772 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685010773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685010774 classical (c) SDRs; Region: SDR_c; cd05233 710685010775 NAD(P) binding site [chemical binding]; other site 710685010776 active site 710685010777 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685010778 CoenzymeA binding site [chemical binding]; other site 710685010779 subunit interaction site [polypeptide binding]; other site 710685010780 PHB binding site; other site 710685010781 Predicted transcriptional regulators [Transcription]; Region: COG1695 710685010782 Transcriptional regulator PadR-like family; Region: PadR; cl17335 710685010783 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 710685010784 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685010785 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685010786 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710685010787 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685010788 hydrophobic ligand binding site; other site 710685010789 Transposase; Region: HTH_Tnp_1; pfam01527 710685010790 HTH-like domain; Region: HTH_21; pfam13276 710685010791 Integrase core domain; Region: rve; pfam00665 710685010792 Integrase core domain; Region: rve_3; pfam13683 710685010793 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685010794 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685010795 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685010796 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685010797 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685010798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685010799 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685010800 classical (c) SDRs; Region: SDR_c; cd05233 710685010801 NAD(P) binding site [chemical binding]; other site 710685010802 active site 710685010803 acyl-CoA synthetase; Validated; Region: PRK08316 710685010804 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685010805 acyl-activating enzyme (AAE) consensus motif; other site 710685010806 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685010807 acyl-activating enzyme (AAE) consensus motif; other site 710685010808 putative AMP binding site [chemical binding]; other site 710685010809 putative active site [active] 710685010810 putative CoA binding site [chemical binding]; other site 710685010811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010813 active site 710685010814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685010815 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 710685010816 NAD(P) binding site [chemical binding]; other site 710685010817 homodimer interface [polypeptide binding]; other site 710685010818 active site 710685010819 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 710685010820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685010821 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685010822 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685010823 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710685010824 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685010825 hypothetical protein; Validated; Region: PRK07121 710685010826 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685010827 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710685010828 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710685010829 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710685010830 active site 710685010831 Fe binding site [ion binding]; other site 710685010832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010834 active site 710685010835 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685010836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685010837 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685010838 classical (c) SDRs; Region: SDR_c; cd05233 710685010839 NAD(P) binding site [chemical binding]; other site 710685010840 active site 710685010841 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685010842 classical (c) SDRs; Region: SDR_c; cd05233 710685010843 NAD(P) binding site [chemical binding]; other site 710685010844 active site 710685010845 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710685010846 comEA protein; Region: comE; TIGR01259 710685010847 Helix-hairpin-helix motif; Region: HHH; pfam00633 710685010848 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 710685010849 Competence protein; Region: Competence; pfam03772 710685010850 hypothetical protein; Reviewed; Region: PRK07914 710685010851 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 710685010852 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 710685010853 Uncharacterized conserved protein [Function unknown]; Region: COG2308 710685010854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710685010855 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710685010856 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685010857 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710685010858 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710685010859 S-formylglutathione hydrolase; Region: PLN02442 710685010860 Putative esterase; Region: Esterase; pfam00756 710685010861 Cutinase; Region: Cutinase; pfam01083 710685010862 ribonuclease Z; Reviewed; Region: PRK00055 710685010863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685010864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685010865 active site 710685010866 catalytic tetrad [active] 710685010867 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 710685010868 FOG: CBS domain [General function prediction only]; Region: COG0517 710685010869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 710685010870 PemK-like protein; Region: PemK; pfam02452 710685010871 GTP-binding protein LepA; Provisional; Region: PRK05433 710685010872 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 710685010873 G1 box; other site 710685010874 putative GEF interaction site [polypeptide binding]; other site 710685010875 GTP/Mg2+ binding site [chemical binding]; other site 710685010876 Switch I region; other site 710685010877 G2 box; other site 710685010878 G3 box; other site 710685010879 Switch II region; other site 710685010880 G4 box; other site 710685010881 G5 box; other site 710685010882 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710685010883 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710685010884 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710685010885 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685010886 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685010887 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710685010888 Rhodanese-like domain; Region: Rhodanese; pfam00581 710685010889 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010890 active site residue [active] 710685010891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 710685010892 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 710685010893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685010894 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685010895 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 710685010896 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 710685010897 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 710685010898 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685010899 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685010900 active site 710685010901 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710685010902 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710685010903 hypothetical protein; Provisional; Region: PRK06185 710685010904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685010905 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710685010906 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710685010907 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710685010908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685010909 dimer interface [polypeptide binding]; other site 710685010910 conserved gate region; other site 710685010911 putative PBP binding loops; other site 710685010912 ABC-ATPase subunit interface; other site 710685010913 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710685010914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685010915 dimer interface [polypeptide binding]; other site 710685010916 conserved gate region; other site 710685010917 putative PBP binding loops; other site 710685010918 ABC-ATPase subunit interface; other site 710685010919 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 710685010920 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 710685010921 Walker A/P-loop; other site 710685010922 ATP binding site [chemical binding]; other site 710685010923 Q-loop/lid; other site 710685010924 ABC transporter signature motif; other site 710685010925 Walker B; other site 710685010926 D-loop; other site 710685010927 H-loop/switch region; other site 710685010928 TOBE domain; Region: TOBE; pfam03459 710685010929 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 710685010930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010931 active site 710685010932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685010933 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 710685010934 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710685010935 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710685010936 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685010937 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685010938 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 710685010939 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710685010940 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710685010941 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710685010942 Walker A/P-loop; other site 710685010943 ATP binding site [chemical binding]; other site 710685010944 Q-loop/lid; other site 710685010945 ABC transporter signature motif; other site 710685010946 Walker B; other site 710685010947 D-loop; other site 710685010948 H-loop/switch region; other site 710685010949 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 710685010950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685010951 substrate binding pocket [chemical binding]; other site 710685010952 membrane-bound complex binding site; other site 710685010953 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710685010954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685010955 dimer interface [polypeptide binding]; other site 710685010956 conserved gate region; other site 710685010957 putative PBP binding loops; other site 710685010958 ABC-ATPase subunit interface; other site 710685010959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710685010960 active site residue [active] 710685010961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685010962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685010963 active site 710685010964 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 710685010965 active site 710685010966 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 710685010967 non-prolyl cis peptide bond; other site 710685010968 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685010969 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 710685010970 Na binding site [ion binding]; other site 710685010971 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 710685010972 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685010973 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 710685010974 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710685010975 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710685010976 putative active site [active] 710685010977 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710685010978 putative active site [active] 710685010979 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 710685010980 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710685010981 Active Sites [active] 710685010982 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 710685010983 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710685010984 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710685010985 coproporphyrinogen III oxidase; Validated; Region: PRK05628 710685010986 HemN C-terminal domain; Region: HemN_C; pfam06969 710685010987 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710685010988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685010989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685010990 DNA binding residues [nucleotide binding] 710685010991 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710685010992 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710685010993 active site 710685010994 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710685010995 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710685010996 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710685010997 KR domain; Region: KR; pfam08659 710685010998 putative NADP binding site [chemical binding]; other site 710685010999 active site 710685011000 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710685011001 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 710685011002 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 710685011003 acyl-activating enzyme (AAE) consensus motif; other site 710685011004 active site 710685011005 AMP binding site [chemical binding]; other site 710685011006 substrate binding site [chemical binding]; other site 710685011007 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 710685011008 Condensation domain; Region: Condensation; pfam00668 710685011009 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685011010 Nonribosomal peptide synthase; Region: NRPS; pfam08415 710685011011 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 710685011012 acyl-activating enzyme (AAE) consensus motif; other site 710685011013 AMP binding site [chemical binding]; other site 710685011014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685011015 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710685011016 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710685011017 Condensation domain; Region: Condensation; pfam00668 710685011018 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685011019 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685011020 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685011021 acyl-activating enzyme (AAE) consensus motif; other site 710685011022 AMP binding site [chemical binding]; other site 710685011023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685011024 Condensation domain; Region: Condensation; pfam00668 710685011025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685011026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685011027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685011028 Condensation domain; Region: Condensation; pfam00668 710685011029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685011030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685011031 acyl-activating enzyme (AAE) consensus motif; other site 710685011032 AMP binding site [chemical binding]; other site 710685011033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685011034 Condensation domain; Region: Condensation; pfam00668 710685011035 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685011036 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 710685011037 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710685011038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685011039 Walker A/P-loop; other site 710685011040 ATP binding site [chemical binding]; other site 710685011041 Q-loop/lid; other site 710685011042 ABC transporter signature motif; other site 710685011043 Walker B; other site 710685011044 D-loop; other site 710685011045 H-loop/switch region; other site 710685011046 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 710685011047 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 710685011048 FAD binding pocket [chemical binding]; other site 710685011049 FAD binding motif [chemical binding]; other site 710685011050 phosphate binding motif [ion binding]; other site 710685011051 NAD binding pocket [chemical binding]; other site 710685011052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710685011053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685011054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685011055 Walker A/P-loop; other site 710685011056 ATP binding site [chemical binding]; other site 710685011057 Q-loop/lid; other site 710685011058 ABC transporter signature motif; other site 710685011059 Walker B; other site 710685011060 D-loop; other site 710685011061 H-loop/switch region; other site 710685011062 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 710685011063 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710685011064 HTH domain; Region: HTH_11; cl17392 710685011065 chaperone protein DnaJ; Provisional; Region: PRK14278 710685011066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710685011067 HSP70 interaction site [polypeptide binding]; other site 710685011068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710685011069 Zn binding sites [ion binding]; other site 710685011070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710685011071 dimer interface [polypeptide binding]; other site 710685011072 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 710685011073 Thioesterase domain; Region: Thioesterase; pfam00975 710685011074 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710685011075 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710685011076 active site 710685011077 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710685011078 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 710685011079 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710685011080 NADP binding site [chemical binding]; other site 710685011081 active site 710685011082 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685011083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685011084 S-adenosylmethionine binding site [chemical binding]; other site 710685011085 K homology RNA-binding domain; Region: KH; smart00322 710685011086 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 710685011087 PhoH-like protein; Region: PhoH; pfam02562 710685011088 metal-binding heat shock protein; Provisional; Region: PRK00016 710685011089 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710685011090 Domain of unknown function DUF21; Region: DUF21; pfam01595 710685011091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710685011092 Transporter associated domain; Region: CorC_HlyC; smart01091 710685011093 GTPase Era; Reviewed; Region: era; PRK00089 710685011094 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 710685011095 G1 box; other site 710685011096 GTP/Mg2+ binding site [chemical binding]; other site 710685011097 Switch I region; other site 710685011098 G2 box; other site 710685011099 Switch II region; other site 710685011100 G3 box; other site 710685011101 G4 box; other site 710685011102 G5 box; other site 710685011103 KH domain; Region: KH_2; pfam07650 710685011104 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710685011105 amidase; Provisional; Region: PRK06061 710685011106 Amidase; Region: Amidase; pfam01425 710685011107 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 710685011108 Recombination protein O N terminal; Region: RecO_N; pfam11967 710685011109 Recombination protein O C terminal; Region: RecO_C; pfam02565 710685011110 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 710685011111 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 710685011112 catalytic residue [active] 710685011113 putative FPP diphosphate binding site; other site 710685011114 putative FPP binding hydrophobic cleft; other site 710685011115 dimer interface [polypeptide binding]; other site 710685011116 putative IPP diphosphate binding site; other site 710685011117 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710685011118 metal binding site 2 [ion binding]; metal-binding site 710685011119 putative DNA binding helix; other site 710685011120 metal binding site 1 [ion binding]; metal-binding site 710685011121 dimer interface [polypeptide binding]; other site 710685011122 structural Zn2+ binding site [ion binding]; other site 710685011123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685011124 dimerization interface [polypeptide binding]; other site 710685011125 putative DNA binding site [nucleotide binding]; other site 710685011126 putative Zn2+ binding site [ion binding]; other site 710685011127 glycyl-tRNA synthetase; Provisional; Region: PRK04173 710685011128 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710685011129 motif 1; other site 710685011130 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 710685011131 active site 710685011132 motif 2; other site 710685011133 motif 3; other site 710685011134 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 710685011135 anticodon binding site; other site 710685011136 Repair protein; Region: Repair_PSII; pfam04536 710685011137 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 710685011138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685011139 Zn2+ binding site [ion binding]; other site 710685011140 Mg2+ binding site [ion binding]; other site 710685011141 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 710685011142 DNA primase; Validated; Region: dnaG; PRK05667 710685011143 CHC2 zinc finger; Region: zf-CHC2; cl17510 710685011144 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710685011145 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710685011146 active site 710685011147 metal binding site [ion binding]; metal-binding site 710685011148 interdomain interaction site; other site 710685011149 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 710685011150 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 710685011151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685011152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685011153 active site 710685011154 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 710685011155 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 710685011156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 710685011157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685011158 putative substrate translocation pore; other site 710685011159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685011160 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685011161 MarR family; Region: MarR; pfam01047 710685011162 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 710685011163 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710685011164 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710685011165 Walker A/P-loop; other site 710685011166 ATP binding site [chemical binding]; other site 710685011167 Q-loop/lid; other site 710685011168 ABC transporter signature motif; other site 710685011169 Walker B; other site 710685011170 D-loop; other site 710685011171 H-loop/switch region; other site 710685011172 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710685011173 Walker A/P-loop; other site 710685011174 ATP binding site [chemical binding]; other site 710685011175 Q-loop/lid; other site 710685011176 ABC transporter signature motif; other site 710685011177 Walker B; other site 710685011178 D-loop; other site 710685011179 H-loop/switch region; other site 710685011180 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710685011181 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710685011182 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710685011183 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685011184 MspA; Region: MspA; pfam09203 710685011185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685011186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685011187 active site 710685011188 phosphorylation site [posttranslational modification] 710685011189 intermolecular recognition site; other site 710685011190 dimerization interface [polypeptide binding]; other site 710685011191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685011192 DNA binding site [nucleotide binding] 710685011193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685011194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685011195 dimerization interface [polypeptide binding]; other site 710685011196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685011197 dimer interface [polypeptide binding]; other site 710685011198 phosphorylation site [posttranslational modification] 710685011199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685011200 ATP binding site [chemical binding]; other site 710685011201 Mg2+ binding site [ion binding]; other site 710685011202 G-X-G motif; other site 710685011203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685011204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685011205 active site 710685011206 phosphorylation site [posttranslational modification] 710685011207 intermolecular recognition site; other site 710685011208 dimerization interface [polypeptide binding]; other site 710685011209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685011210 DNA binding site [nucleotide binding] 710685011211 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710685011212 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710685011213 active site 710685011214 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710685011215 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011216 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011217 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011218 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011219 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011220 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011221 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710685011222 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 710685011223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685011224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685011225 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 710685011226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685011227 active site 710685011228 HIGH motif; other site 710685011229 nucleotide binding site [chemical binding]; other site 710685011230 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685011231 active site 710685011232 KMSKS motif; other site 710685011233 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685011234 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685011235 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685011236 cyclase homology domain; Region: CHD; cd07302 710685011237 nucleotidyl binding site; other site 710685011238 metal binding site [ion binding]; metal-binding site 710685011239 dimer interface [polypeptide binding]; other site 710685011240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710685011241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710685011242 catalytic residue [active] 710685011243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685011244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685011245 active site 710685011246 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685011247 classical (c) SDRs; Region: SDR_c; cd05233 710685011248 NAD(P) binding site [chemical binding]; other site 710685011249 active site 710685011250 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710685011251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710685011252 Walker A/P-loop; other site 710685011253 ATP binding site [chemical binding]; other site 710685011254 Q-loop/lid; other site 710685011255 ABC transporter signature motif; other site 710685011256 Walker B; other site 710685011257 D-loop; other site 710685011258 H-loop/switch region; other site 710685011259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710685011260 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710685011261 Walker A/P-loop; other site 710685011262 ATP binding site [chemical binding]; other site 710685011263 Q-loop/lid; other site 710685011264 ABC transporter signature motif; other site 710685011265 Walker B; other site 710685011266 D-loop; other site 710685011267 H-loop/switch region; other site 710685011268 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710685011269 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 710685011270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685011271 dimer interface [polypeptide binding]; other site 710685011272 conserved gate region; other site 710685011273 putative PBP binding loops; other site 710685011274 ABC-ATPase subunit interface; other site 710685011275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710685011276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685011277 dimer interface [polypeptide binding]; other site 710685011278 conserved gate region; other site 710685011279 putative PBP binding loops; other site 710685011280 ABC-ATPase subunit interface; other site 710685011281 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710685011282 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 710685011283 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685011284 classical (c) SDRs; Region: SDR_c; cd05233 710685011285 NAD(P) binding site [chemical binding]; other site 710685011286 active site 710685011287 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685011288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685011289 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685011290 nucleotide binding site [chemical binding]; other site 710685011291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685011292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685011293 active site 710685011294 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710685011295 DJ-1 family protein; Region: not_thiJ; TIGR01383 710685011296 conserved cys residue [active] 710685011297 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710685011298 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710685011299 conserved cys residue [active] 710685011300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685011301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685011302 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 710685011303 short chain dehydrogenase; Provisional; Region: PRK05854 710685011304 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710685011305 putative NAD(P) binding site [chemical binding]; other site 710685011306 active site 710685011307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685011308 Short C-terminal domain; Region: SHOCT; pfam09851 710685011309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685011310 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 710685011311 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685011312 NAD binding site [chemical binding]; other site 710685011313 catalytic Zn binding site [ion binding]; other site 710685011314 substrate binding site [chemical binding]; other site 710685011315 structural Zn binding site [ion binding]; other site 710685011316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685011317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685011318 DNA binding residues [nucleotide binding] 710685011319 dimerization interface [polypeptide binding]; other site 710685011320 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685011321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685011322 S-adenosylmethionine binding site [chemical binding]; other site 710685011323 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 710685011324 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 710685011325 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685011326 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685011327 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 710685011328 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685011329 diacylglycerol kinase; Reviewed; Region: PRK11914 710685011330 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710685011331 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710685011332 FAD binding domain; Region: FAD_binding_4; pfam01565 710685011333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685011334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685011335 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 710685011336 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685011337 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685011338 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685011339 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710685011340 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710685011341 dimer interface [polypeptide binding]; other site 710685011342 active site 710685011343 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710685011344 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710685011345 dimer interface [polypeptide binding]; other site 710685011346 active site 710685011347 acyl carrier protein; Provisional; Region: acpP; PRK00982 710685011348 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710685011349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710685011350 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710685011351 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710685011352 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 710685011353 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 710685011354 dimer interface [polypeptide binding]; other site 710685011355 TPP-binding site [chemical binding]; other site 710685011356 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 710685011357 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 710685011358 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710685011359 dimer interface [polypeptide binding]; other site 710685011360 catalytic triad [active] 710685011361 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710685011362 FMN binding site [chemical binding]; other site 710685011363 dimer interface [polypeptide binding]; other site 710685011364 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685011365 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 710685011366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685011367 Ligand Binding Site [chemical binding]; other site 710685011368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685011369 Ligand Binding Site [chemical binding]; other site 710685011370 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685011371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685011372 active site 710685011373 metal binding site [ion binding]; metal-binding site 710685011374 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 710685011375 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 710685011376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710685011377 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710685011378 active site 710685011379 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 710685011380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685011381 motif II; other site 710685011382 hypothetical protein; Provisional; Region: PRK07908 710685011383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685011384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685011385 homodimer interface [polypeptide binding]; other site 710685011386 catalytic residue [active] 710685011387 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710685011388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 710685011389 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710685011390 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 710685011391 Putative zinc ribbon domain; Region: DUF164; pfam02591 710685011392 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 710685011393 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 710685011394 RNA/DNA hybrid binding site [nucleotide binding]; other site 710685011395 active site 710685011396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685011397 catalytic core [active] 710685011398 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685011399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685011400 sequence-specific DNA binding site [nucleotide binding]; other site 710685011401 salt bridge; other site 710685011402 Cupin domain; Region: Cupin_2; pfam07883 710685011403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685011404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685011405 S-adenosylmethionine binding site [chemical binding]; other site 710685011406 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 710685011407 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 710685011408 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710685011409 DNA binding site [nucleotide binding] 710685011410 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710685011411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685011412 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710685011413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685011414 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710685011415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685011416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685011417 dimerization interface [polypeptide binding]; other site 710685011418 putative DNA binding site [nucleotide binding]; other site 710685011419 putative Zn2+ binding site [ion binding]; other site 710685011420 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 710685011421 arsenical-resistance protein; Region: acr3; TIGR00832 710685011422 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710685011423 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710685011424 active site 710685011425 Low molecular weight phosphatase family; Region: LMWPc; cl00105 710685011426 active site 710685011427 DinB superfamily; Region: DinB_2; pfam12867 710685011428 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710685011429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685011430 DNA-binding site [nucleotide binding]; DNA binding site 710685011431 FCD domain; Region: FCD; pfam07729 710685011432 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 710685011433 putative active site; other site 710685011434 putative metal binding residues [ion binding]; other site 710685011435 signature motif; other site 710685011436 putative triphosphate binding site [ion binding]; other site 710685011437 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 710685011438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685011439 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685011440 substrate binding site [chemical binding]; other site 710685011441 oxyanion hole (OAH) forming residues; other site 710685011442 trimer interface [polypeptide binding]; other site 710685011443 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 710685011444 oligomerization interface [polypeptide binding]; other site 710685011445 active site 710685011446 metal binding site [ion binding]; metal-binding site 710685011447 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685011448 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685011449 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685011450 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685011451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685011452 Coenzyme A binding pocket [chemical binding]; other site 710685011453 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710685011454 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710685011455 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685011456 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 710685011457 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710685011458 metal binding triad; other site 710685011459 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710685011460 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710685011461 metal binding triad; other site 710685011462 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710685011463 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685011464 CoenzymeA binding site [chemical binding]; other site 710685011465 subunit interaction site [polypeptide binding]; other site 710685011466 PHB binding site; other site 710685011467 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685011468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685011469 Predicted membrane protein [Function unknown]; Region: COG2259 710685011470 glutamine synthetase, type I; Region: GlnA; TIGR00653 710685011471 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710685011472 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685011473 RDD family; Region: RDD; pfam06271 710685011474 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710685011475 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710685011476 active site 710685011477 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 710685011478 lipoyl synthase; Provisional; Region: PRK05481 710685011479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685011480 FeS/SAM binding site; other site 710685011481 lipoate-protein ligase B; Provisional; Region: PRK14345 710685011482 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 710685011483 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 710685011484 putative NAD(P) binding site [chemical binding]; other site 710685011485 putative active site [active] 710685011486 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710685011487 E3 interaction surface; other site 710685011488 lipoyl attachment site [posttranslational modification]; other site 710685011489 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710685011490 E3 interaction surface; other site 710685011491 lipoyl attachment site [posttranslational modification]; other site 710685011492 e3 binding domain; Region: E3_binding; pfam02817 710685011493 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 710685011494 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710685011495 short chain dehydrogenase; Validated; Region: PRK05855 710685011496 classical (c) SDRs; Region: SDR_c; cd05233 710685011497 NAD(P) binding site [chemical binding]; other site 710685011498 active site 710685011499 multifunctional aminopeptidase A; Provisional; Region: PRK00913 710685011500 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 710685011501 interface (dimer of trimers) [polypeptide binding]; other site 710685011502 Substrate-binding/catalytic site; other site 710685011503 Zn-binding sites [ion binding]; other site 710685011504 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685011505 cyclase homology domain; Region: CHD; cd07302 710685011506 nucleotidyl binding site; other site 710685011507 metal binding site [ion binding]; metal-binding site 710685011508 dimer interface [polypeptide binding]; other site 710685011509 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 710685011510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710685011511 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 710685011512 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 710685011513 homodimer interface [polypeptide binding]; other site 710685011514 substrate-cofactor binding pocket; other site 710685011515 catalytic residue [active] 710685011516 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685011517 cobalamin synthase; Reviewed; Region: cobS; PRK00235 710685011518 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 710685011519 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 710685011520 putative dimer interface [polypeptide binding]; other site 710685011521 active site pocket [active] 710685011522 putative cataytic base [active] 710685011523 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 710685011524 homotrimer interface [polypeptide binding]; other site 710685011525 Walker A motif; other site 710685011526 GTP binding site [chemical binding]; other site 710685011527 Walker B motif; other site 710685011528 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 710685011529 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 710685011530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685011531 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685011532 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685011533 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 710685011534 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710685011535 substrate binding site [chemical binding]; other site 710685011536 ATP binding site [chemical binding]; other site 710685011537 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 710685011538 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710685011539 active site 710685011540 dimer interface [polypeptide binding]; other site 710685011541 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710685011542 Ligand Binding Site [chemical binding]; other site 710685011543 Molecular Tunnel; other site 710685011544 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 710685011545 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 710685011546 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 710685011547 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710685011548 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 710685011549 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 710685011550 heme bH binding site [chemical binding]; other site 710685011551 intrachain domain interface; other site 710685011552 heme bL binding site [chemical binding]; other site 710685011553 interchain domain interface [polypeptide binding]; other site 710685011554 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 710685011555 Qo binding site; other site 710685011556 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 710685011557 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710685011558 iron-sulfur cluster [ion binding]; other site 710685011559 [2Fe-2S] cluster binding site [ion binding]; other site 710685011560 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710685011561 Cytochrome c; Region: Cytochrom_C; pfam00034 710685011562 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710685011563 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 710685011564 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 710685011565 Subunit I/III interface [polypeptide binding]; other site 710685011566 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 710685011567 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710685011568 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710685011569 hypothetical protein; Validated; Region: PRK07883 710685011570 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710685011571 active site 710685011572 catalytic site [active] 710685011573 substrate binding site [chemical binding]; other site 710685011574 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710685011575 GIY-YIG motif/motif A; other site 710685011576 active site 710685011577 catalytic site [active] 710685011578 putative DNA binding site [nucleotide binding]; other site 710685011579 metal binding site [ion binding]; metal-binding site 710685011580 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685011581 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685011582 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 710685011583 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685011584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685011585 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710685011586 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710685011587 acyl-activating enzyme (AAE) consensus motif; other site 710685011588 putative AMP binding site [chemical binding]; other site 710685011589 putative active site [active] 710685011590 putative CoA binding site [chemical binding]; other site 710685011591 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685011592 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710685011593 putative hydrophobic ligand binding site [chemical binding]; other site 710685011594 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710685011595 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710685011596 P loop; other site 710685011597 Nucleotide binding site [chemical binding]; other site 710685011598 DTAP/Switch II; other site 710685011599 Switch I; other site 710685011600 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685011601 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685011602 putative acyl-acceptor binding pocket; other site 710685011603 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710685011604 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 710685011605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685011606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685011607 active site 710685011608 ATP binding site [chemical binding]; other site 710685011609 substrate binding site [chemical binding]; other site 710685011610 activation loop (A-loop); other site 710685011611 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710685011612 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710685011613 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710685011614 substrate binding pocket [chemical binding]; other site 710685011615 chain length determination region; other site 710685011616 substrate-Mg2+ binding site; other site 710685011617 catalytic residues [active] 710685011618 aspartate-rich region 1; other site 710685011619 active site lid residues [active] 710685011620 aspartate-rich region 2; other site 710685011621 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 710685011622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 710685011623 MraZ protein; Region: MraZ; pfam02381 710685011624 MraZ protein; Region: MraZ; pfam02381 710685011625 MraW methylase family; Region: Methyltransf_5; cl17771 710685011626 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 710685011627 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710685011628 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 710685011629 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710685011630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 710685011631 Probable transposase; Region: OrfB_IS605; pfam01385 710685011632 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 710685011633 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 710685011634 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710685011635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685011636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710685011637 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 710685011638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685011639 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710685011640 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 710685011641 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 710685011642 Mg++ binding site [ion binding]; other site 710685011643 putative catalytic motif [active] 710685011644 putative substrate binding site [chemical binding]; other site 710685011645 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 710685011646 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 710685011647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685011648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710685011649 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 710685011650 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 710685011651 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 710685011652 active site 710685011653 homodimer interface [polypeptide binding]; other site 710685011654 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 710685011655 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710685011656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710685011657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710685011658 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 710685011659 Cell division protein FtsQ; Region: FtsQ; pfam03799 710685011660 cell division protein FtsZ; Validated; Region: PRK09330 710685011661 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 710685011662 nucleotide binding site [chemical binding]; other site 710685011663 SulA interaction site; other site 710685011664 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 710685011665 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 710685011666 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 710685011667 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710685011668 catalytic residue [active] 710685011669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 710685011670 Predicted integral membrane protein [Function unknown]; Region: COG0762 710685011671 DivIVA domain; Region: DivI1A_domain; TIGR03544 710685011672 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710685011673 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 710685011674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685011675 active site 710685011676 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 710685011677 putative hydrophobic ligand binding site [chemical binding]; other site 710685011678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685011679 TIGR01777 family protein; Region: yfcH 710685011680 NAD(P) binding site [chemical binding]; other site 710685011681 active site 710685011682 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710685011683 catalytic triad [active] 710685011684 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685011685 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685011686 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710685011687 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 710685011688 putative active site [active] 710685011689 catalytic site [active] 710685011690 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 710685011691 putative active site [active] 710685011692 catalytic site [active] 710685011693 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685011694 Cytochrome P450; Region: p450; cl12078 710685011695 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710685011696 Winged helix-turn helix; Region: HTH_29; pfam13551 710685011697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 710685011698 Integrase core domain; Region: rve; pfam00665 710685011699 Integrase core domain; Region: rve_3; pfam13683 710685011700 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685011701 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685011702 active site 710685011703 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685011704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685011705 short chain dehydrogenase; Provisional; Region: PRK08267 710685011706 classical (c) SDRs; Region: SDR_c; cd05233 710685011707 NAD(P) binding site [chemical binding]; other site 710685011708 active site 710685011709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685011710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685011711 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710685011712 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710685011713 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710685011714 active site 710685011715 dimer interface [polypeptide binding]; other site 710685011716 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710685011717 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710685011718 active site 710685011719 FMN binding site [chemical binding]; other site 710685011720 substrate binding site [chemical binding]; other site 710685011721 3Fe-4S cluster binding site [ion binding]; other site 710685011722 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710685011723 domain interface; other site 710685011724 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710685011725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685011726 pyruvate kinase; Provisional; Region: PRK06247 710685011727 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710685011728 domain interfaces; other site 710685011729 active site 710685011730 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685011731 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685011732 active site 710685011733 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685011734 catalytic triad [active] 710685011735 dimer interface [polypeptide binding]; other site 710685011736 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 710685011737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685011738 Walker A/P-loop; other site 710685011739 ATP binding site [chemical binding]; other site 710685011740 Q-loop/lid; other site 710685011741 ABC transporter signature motif; other site 710685011742 Walker B; other site 710685011743 D-loop; other site 710685011744 H-loop/switch region; other site 710685011745 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 710685011746 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710685011747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685011748 Walker A/P-loop; other site 710685011749 ATP binding site [chemical binding]; other site 710685011750 Q-loop/lid; other site 710685011751 ABC transporter signature motif; other site 710685011752 Walker B; other site 710685011753 D-loop; other site 710685011754 H-loop/switch region; other site 710685011755 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710685011756 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710685011757 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 710685011758 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 710685011759 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 710685011760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685011761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685011762 substrate binding pocket [chemical binding]; other site 710685011763 membrane-bound complex binding site; other site 710685011764 hinge residues; other site 710685011765 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710685011766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685011767 dimer interface [polypeptide binding]; other site 710685011768 conserved gate region; other site 710685011769 putative PBP binding loops; other site 710685011770 ABC-ATPase subunit interface; other site 710685011771 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685011772 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710685011773 Walker A/P-loop; other site 710685011774 ATP binding site [chemical binding]; other site 710685011775 Q-loop/lid; other site 710685011776 ABC transporter signature motif; other site 710685011777 Walker B; other site 710685011778 D-loop; other site 710685011779 H-loop/switch region; other site 710685011780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710685011781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685011782 ATP binding site [chemical binding]; other site 710685011783 Mg2+ binding site [ion binding]; other site 710685011784 G-X-G motif; other site 710685011785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710685011786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685011787 active site 710685011788 phosphorylation site [posttranslational modification] 710685011789 intermolecular recognition site; other site 710685011790 dimerization interface [polypeptide binding]; other site 710685011791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710685011792 DNA binding residues [nucleotide binding] 710685011793 dimerization interface [polypeptide binding]; other site 710685011794 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710685011795 Ferritin-like domain; Region: Ferritin; pfam00210 710685011796 dimerization interface [polypeptide binding]; other site 710685011797 DPS ferroxidase diiron center [ion binding]; other site 710685011798 ion pore; other site 710685011799 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710685011800 cyclase homology domain; Region: CHD; cd07302 710685011801 nucleotidyl binding site; other site 710685011802 metal binding site [ion binding]; metal-binding site 710685011803 dimer interface [polypeptide binding]; other site 710685011804 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 710685011805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685011806 active site 710685011807 phosphorylation site [posttranslational modification] 710685011808 intermolecular recognition site; other site 710685011809 dimerization interface [polypeptide binding]; other site 710685011810 ANTAR domain; Region: ANTAR; pfam03861 710685011811 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 710685011812 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 710685011813 dimerization interface [polypeptide binding]; other site 710685011814 ligand binding site [chemical binding]; other site 710685011815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710685011816 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710685011817 TM-ABC transporter signature motif; other site 710685011818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710685011819 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710685011820 TM-ABC transporter signature motif; other site 710685011821 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710685011822 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710685011823 Walker A/P-loop; other site 710685011824 ATP binding site [chemical binding]; other site 710685011825 Q-loop/lid; other site 710685011826 ABC transporter signature motif; other site 710685011827 Walker B; other site 710685011828 D-loop; other site 710685011829 H-loop/switch region; other site 710685011830 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710685011831 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710685011832 Walker A/P-loop; other site 710685011833 ATP binding site [chemical binding]; other site 710685011834 Q-loop/lid; other site 710685011835 ABC transporter signature motif; other site 710685011836 Walker B; other site 710685011837 D-loop; other site 710685011838 H-loop/switch region; other site 710685011839 lipid-transfer protein; Provisional; Region: PRK06059 710685011840 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685011841 active site 710685011842 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685011843 DNA polymerase I; Provisional; Region: PRK05755 710685011844 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710685011845 active site 710685011846 metal binding site 1 [ion binding]; metal-binding site 710685011847 putative 5' ssDNA interaction site; other site 710685011848 metal binding site 3; metal-binding site 710685011849 metal binding site 2 [ion binding]; metal-binding site 710685011850 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710685011851 putative DNA binding site [nucleotide binding]; other site 710685011852 putative metal binding site [ion binding]; other site 710685011853 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 710685011854 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 710685011855 active site 710685011856 DNA binding site [nucleotide binding] 710685011857 catalytic site [active] 710685011858 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 710685011859 Protease prsW family; Region: PrsW-protease; pfam13367 710685011860 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 710685011861 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 710685011862 RNA binding site [nucleotide binding]; other site 710685011863 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 710685011864 RNA binding site [nucleotide binding]; other site 710685011865 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710685011866 RNA binding site [nucleotide binding]; other site 710685011867 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 710685011868 RNA binding site [nucleotide binding]; other site 710685011869 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 710685011870 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710685011871 CoA-binding site [chemical binding]; other site 710685011872 ATP-binding [chemical binding]; other site 710685011873 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 710685011874 Protein of unknown function (DUF402); Region: DUF402; cl00979 710685011875 excinuclease ABC subunit B; Provisional; Region: PRK05298 710685011876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685011877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685011878 nucleotide binding region [chemical binding]; other site 710685011879 ATP-binding site [chemical binding]; other site 710685011880 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710685011881 UvrB/uvrC motif; Region: UVR; pfam02151 710685011882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685011883 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 710685011884 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 710685011885 MgtC family; Region: MgtC; pfam02308 710685011886 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685011887 hydrophobic ligand binding site; other site 710685011888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685011889 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685011890 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 710685011891 active site 710685011892 Fe-S cluster binding site [ion binding]; other site 710685011893 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710685011894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685011895 Ligand Binding Site [chemical binding]; other site 710685011896 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 710685011897 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710685011898 putative active site [active] 710685011899 catalytic triad [active] 710685011900 putative dimer interface [polypeptide binding]; other site 710685011901 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 710685011902 catalytic residue [active] 710685011903 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685011904 Cytochrome P450; Region: p450; cl12078 710685011905 short chain dehydrogenase; Provisional; Region: PRK08303 710685011906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685011907 NAD(P) binding site [chemical binding]; other site 710685011908 active site 710685011909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685011910 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710685011911 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710685011912 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710685011913 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710685011914 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710685011915 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710685011916 CHAT domain; Region: CHAT; cl17868 710685011917 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710685011918 Predicted esterase [General function prediction only]; Region: COG0627 710685011919 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 710685011920 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 710685011921 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710685011922 dimer interface [polypeptide binding]; other site 710685011923 putative anticodon binding site; other site 710685011924 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710685011925 motif 1; other site 710685011926 dimer interface [polypeptide binding]; other site 710685011927 active site 710685011928 motif 2; other site 710685011929 motif 3; other site 710685011930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685011931 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 710685011932 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710685011933 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710685011934 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 710685011935 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710685011936 23S rRNA binding site [nucleotide binding]; other site 710685011937 L21 binding site [polypeptide binding]; other site 710685011938 L13 binding site [polypeptide binding]; other site 710685011939 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710685011940 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 710685011941 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710685011942 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685011943 classical (c) SDRs; Region: SDR_c; cd05233 710685011944 NAD(P) binding site [chemical binding]; other site 710685011945 active site 710685011946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685011947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685011948 active site 710685011949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 710685011950 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685011951 cyclase homology domain; Region: CHD; cd07302 710685011952 nucleotidyl binding site; other site 710685011953 metal binding site [ion binding]; metal-binding site 710685011954 dimer interface [polypeptide binding]; other site 710685011955 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710685011956 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710685011957 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710685011958 dimer interface [polypeptide binding]; other site 710685011959 motif 1; other site 710685011960 active site 710685011961 motif 2; other site 710685011962 motif 3; other site 710685011963 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710685011964 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710685011965 putative tRNA-binding site [nucleotide binding]; other site 710685011966 B3/4 domain; Region: B3_4; pfam03483 710685011967 tRNA synthetase B5 domain; Region: B5; smart00874 710685011968 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710685011969 dimer interface [polypeptide binding]; other site 710685011970 motif 1; other site 710685011971 motif 3; other site 710685011972 motif 2; other site 710685011973 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 710685011974 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 710685011975 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 710685011976 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710685011977 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 710685011978 heterotetramer interface [polypeptide binding]; other site 710685011979 active site pocket [active] 710685011980 cleavage site 710685011981 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 710685011982 feedback inhibition sensing region; other site 710685011983 homohexameric interface [polypeptide binding]; other site 710685011984 nucleotide binding site [chemical binding]; other site 710685011985 N-acetyl-L-glutamate binding site [chemical binding]; other site 710685011986 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 710685011987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685011988 inhibitor-cofactor binding pocket; inhibition site 710685011989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685011990 catalytic residue [active] 710685011991 ornithine carbamoyltransferase; Provisional; Region: PRK00779 710685011992 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710685011993 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710685011994 arginine repressor; Provisional; Region: PRK03341 710685011995 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 710685011996 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 710685011997 argininosuccinate synthase; Provisional; Region: PRK13820 710685011998 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 710685011999 ANP binding site [chemical binding]; other site 710685012000 Substrate Binding Site II [chemical binding]; other site 710685012001 Substrate Binding Site I [chemical binding]; other site 710685012002 argininosuccinate lyase; Provisional; Region: PRK00855 710685012003 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 710685012004 active sites [active] 710685012005 tetramer interface [polypeptide binding]; other site 710685012006 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710685012007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685012008 ABC transporter; Region: ABC_tran_2; pfam12848 710685012009 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685012010 acyl-CoA synthetase; Validated; Region: PRK07868 710685012011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012013 acyl-activating enzyme (AAE) consensus motif; other site 710685012014 active site 710685012015 AMP binding site [chemical binding]; other site 710685012016 CoA binding site [chemical binding]; other site 710685012017 Uncharacterized conserved protein [Function unknown]; Region: COG2835 710685012018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012020 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685012021 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710685012022 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710685012023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685012024 Walker A/P-loop; other site 710685012025 ATP binding site [chemical binding]; other site 710685012026 Q-loop/lid; other site 710685012027 ABC transporter signature motif; other site 710685012028 Walker B; other site 710685012029 D-loop; other site 710685012030 H-loop/switch region; other site 710685012031 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 710685012032 active site 710685012033 DNA binding site [nucleotide binding] 710685012034 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710685012035 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710685012036 active site 710685012037 HIGH motif; other site 710685012038 dimer interface [polypeptide binding]; other site 710685012039 KMSKS motif; other site 710685012040 S4 RNA-binding domain; Region: S4; smart00363 710685012041 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 710685012042 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710685012043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685012044 active site 710685012045 motif I; other site 710685012046 motif II; other site 710685012047 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710685012048 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 710685012049 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 710685012050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710685012051 RNA binding surface [nucleotide binding]; other site 710685012052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685012053 S-adenosylmethionine binding site [chemical binding]; other site 710685012054 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 710685012055 ATP-NAD kinase; Region: NAD_kinase; pfam01513 710685012056 DNA repair protein RecN; Region: recN; TIGR00634 710685012057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685012058 Walker A/P-loop; other site 710685012059 ATP binding site [chemical binding]; other site 710685012060 Q-loop/lid; other site 710685012061 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710685012062 ABC transporter signature motif; other site 710685012063 Walker B; other site 710685012064 D-loop; other site 710685012065 H-loop/switch region; other site 710685012066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012068 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710685012069 active site 710685012070 metal binding site [ion binding]; metal-binding site 710685012071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685012072 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 710685012073 Thiamine pyrophosphokinase; Region: TPK; cl08415 710685012074 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 710685012075 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 710685012076 CTP synthetase; Validated; Region: pyrG; PRK05380 710685012077 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 710685012078 Catalytic site [active] 710685012079 active site 710685012080 UTP binding site [chemical binding]; other site 710685012081 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710685012082 active site 710685012083 putative oxyanion hole; other site 710685012084 catalytic triad [active] 710685012085 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710685012086 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710685012087 dimer interface [polypeptide binding]; other site 710685012088 ADP-ribose binding site [chemical binding]; other site 710685012089 active site 710685012090 nudix motif; other site 710685012091 metal binding site [ion binding]; metal-binding site 710685012092 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 710685012093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685012094 active site 710685012095 DNA binding site [nucleotide binding] 710685012096 Int/Topo IB signature motif; other site 710685012097 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710685012098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685012099 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710685012100 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685012101 P-loop; other site 710685012102 Magnesium ion binding site [ion binding]; other site 710685012103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710685012104 Magnesium ion binding site [ion binding]; other site 710685012105 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 710685012106 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 710685012107 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 710685012108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710685012109 RNA binding surface [nucleotide binding]; other site 710685012110 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 710685012111 active site 710685012112 cytidylate kinase; Provisional; Region: cmk; PRK00023 710685012113 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 710685012114 CMP-binding site; other site 710685012115 The sites determining sugar specificity; other site 710685012116 GTP-binding protein Der; Reviewed; Region: PRK03003 710685012117 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 710685012118 G1 box; other site 710685012119 GTP/Mg2+ binding site [chemical binding]; other site 710685012120 Switch I region; other site 710685012121 G2 box; other site 710685012122 Switch II region; other site 710685012123 G3 box; other site 710685012124 G4 box; other site 710685012125 G5 box; other site 710685012126 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 710685012127 G1 box; other site 710685012128 GTP/Mg2+ binding site [chemical binding]; other site 710685012129 Switch I region; other site 710685012130 G2 box; other site 710685012131 G3 box; other site 710685012132 Switch II region; other site 710685012133 G4 box; other site 710685012134 G5 box; other site 710685012135 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710685012136 hypothetical protein; Provisional; Region: PRK10621 710685012137 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710685012138 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 710685012139 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 710685012140 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685012141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685012142 active site 710685012143 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710685012144 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685012145 active site 710685012146 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685012147 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685012148 classical (c) SDRs; Region: SDR_c; cd05233 710685012149 NAD(P) binding site [chemical binding]; other site 710685012150 active site 710685012151 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 710685012152 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685012153 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685012154 enoyl-CoA hydratase; Provisional; Region: PRK07799 710685012155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685012156 substrate binding site [chemical binding]; other site 710685012157 oxyanion hole (OAH) forming residues; other site 710685012158 trimer interface [polypeptide binding]; other site 710685012159 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012161 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685012162 anti sigma factor interaction site; other site 710685012163 regulatory phosphorylation site [posttranslational modification]; other site 710685012164 B12 binding domain; Region: B12-binding_2; pfam02607 710685012165 B12 binding domain; Region: B12-binding; pfam02310 710685012166 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685012167 Condensation domain; Region: Condensation; pfam00668 710685012168 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012169 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685012170 acyl-activating enzyme (AAE) consensus motif; other site 710685012171 AMP binding site [chemical binding]; other site 710685012172 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012173 Condensation domain; Region: Condensation; pfam00668 710685012174 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012175 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012176 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012177 acyl-activating enzyme (AAE) consensus motif; other site 710685012178 AMP binding site [chemical binding]; other site 710685012179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012180 Condensation domain; Region: Condensation; pfam00668 710685012181 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012182 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012183 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012184 acyl-activating enzyme (AAE) consensus motif; other site 710685012185 AMP binding site [chemical binding]; other site 710685012186 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012187 Condensation domain; Region: Condensation; pfam00668 710685012188 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012191 acyl-activating enzyme (AAE) consensus motif; other site 710685012192 AMP binding site [chemical binding]; other site 710685012193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012194 Condensation domain; Region: Condensation; pfam00668 710685012195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012196 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012197 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685012198 acyl-activating enzyme (AAE) consensus motif; other site 710685012199 AMP binding site [chemical binding]; other site 710685012200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012201 Condensation domain; Region: Condensation; pfam00668 710685012202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012203 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012204 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012205 acyl-activating enzyme (AAE) consensus motif; other site 710685012206 AMP binding site [chemical binding]; other site 710685012207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012208 peptide synthase; Provisional; Region: PRK12467 710685012209 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012210 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012211 acyl-activating enzyme (AAE) consensus motif; other site 710685012212 AMP binding site [chemical binding]; other site 710685012213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012214 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012216 acyl-activating enzyme (AAE) consensus motif; other site 710685012217 AMP binding site [chemical binding]; other site 710685012218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012219 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685012220 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012221 acyl-activating enzyme (AAE) consensus motif; other site 710685012222 AMP binding site [chemical binding]; other site 710685012223 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012224 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012225 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012226 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012227 acyl-activating enzyme (AAE) consensus motif; other site 710685012228 AMP binding site [chemical binding]; other site 710685012229 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012230 Condensation domain; Region: Condensation; pfam00668 710685012231 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012232 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012233 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012234 acyl-activating enzyme (AAE) consensus motif; other site 710685012235 AMP binding site [chemical binding]; other site 710685012236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012237 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 710685012238 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012239 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012240 acyl-activating enzyme (AAE) consensus motif; other site 710685012241 AMP binding site [chemical binding]; other site 710685012242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012243 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710685012244 Transport protein; Region: actII; TIGR00833 710685012245 Peptidase C80 family; Region: Peptidase_C80; pfam11713 710685012246 Cutinase; Region: Cutinase; pfam01083 710685012247 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 710685012248 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685012249 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685012250 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710685012251 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710685012252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012253 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685012254 classical (c) SDRs; Region: SDR_c; cd05233 710685012255 NAD(P) binding site [chemical binding]; other site 710685012256 active site 710685012257 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685012258 Cytochrome P450; Region: p450; cl12078 710685012259 acyl-CoA synthetase; Provisional; Region: PRK13388 710685012260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012261 acyl-activating enzyme (AAE) consensus motif; other site 710685012262 AMP binding site [chemical binding]; other site 710685012263 active site 710685012264 CoA binding site [chemical binding]; other site 710685012265 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685012266 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685012267 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685012268 [2Fe-2S] cluster binding site [ion binding]; other site 710685012269 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685012270 hydrophobic ligand binding site; other site 710685012271 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 710685012272 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685012273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685012274 substrate binding site [chemical binding]; other site 710685012275 oxyanion hole (OAH) forming residues; other site 710685012276 trimer interface [polypeptide binding]; other site 710685012277 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012278 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012279 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685012280 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685012281 active site 710685012282 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685012283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685012284 active site 710685012285 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685012286 classical (c) SDRs; Region: SDR_c; cd05233 710685012287 NAD(P) binding site [chemical binding]; other site 710685012288 active site 710685012289 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710685012290 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710685012291 tetramer interface [polypeptide binding]; other site 710685012292 TPP-binding site [chemical binding]; other site 710685012293 heterodimer interface [polypeptide binding]; other site 710685012294 phosphorylation loop region [posttranslational modification] 710685012295 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710685012296 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710685012297 alpha subunit interface [polypeptide binding]; other site 710685012298 TPP binding site [chemical binding]; other site 710685012299 heterodimer interface [polypeptide binding]; other site 710685012300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685012301 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 710685012302 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710685012303 E3 interaction surface; other site 710685012304 lipoyl attachment site [posttranslational modification]; other site 710685012305 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685012306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685012307 substrate binding site [chemical binding]; other site 710685012308 oxyanion hole (OAH) forming residues; other site 710685012309 trimer interface [polypeptide binding]; other site 710685012310 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710685012311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012312 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685012313 acyl-activating enzyme (AAE) consensus motif; other site 710685012314 acyl-activating enzyme (AAE) consensus motif; other site 710685012315 putative AMP binding site [chemical binding]; other site 710685012316 putative active site [active] 710685012317 putative CoA binding site [chemical binding]; other site 710685012318 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685012319 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685012320 NAD binding site [chemical binding]; other site 710685012321 catalytic Zn binding site [ion binding]; other site 710685012322 substrate binding site [chemical binding]; other site 710685012323 structural Zn binding site [ion binding]; other site 710685012324 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685012325 Cytochrome P450; Region: p450; cl12078 710685012326 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 710685012327 iron-sulfur cluster [ion binding]; other site 710685012328 [2Fe-2S] cluster binding site [ion binding]; other site 710685012329 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685012330 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685012331 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710685012332 classical (c) SDRs; Region: SDR_c; cd05233 710685012333 NAD(P) binding site [chemical binding]; other site 710685012334 active site 710685012335 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685012336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685012337 DNA-binding site [nucleotide binding]; DNA binding site 710685012338 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710685012339 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012340 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012341 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012342 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685012344 Cytochrome P450; Region: p450; cl12078 710685012345 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685012346 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685012347 [2Fe-2S] cluster binding site [ion binding]; other site 710685012348 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685012349 hydrophobic ligand binding site; other site 710685012350 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 710685012351 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 710685012352 acyl-activating enzyme (AAE) consensus motif; other site 710685012353 putative AMP binding site [chemical binding]; other site 710685012354 putative active site [active] 710685012355 putative CoA binding site [chemical binding]; other site 710685012356 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685012357 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685012358 active site 2 [active] 710685012359 active site 1 [active] 710685012360 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685012361 active site 2 [active] 710685012362 active site 1 [active] 710685012363 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710685012364 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685012365 NAD binding site [chemical binding]; other site 710685012366 catalytic residues [active] 710685012367 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 710685012368 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685012369 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685012370 [2Fe-2S] cluster binding site [ion binding]; other site 710685012371 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 710685012372 putative alpha subunit interface [polypeptide binding]; other site 710685012373 putative active site [active] 710685012374 putative substrate binding site [chemical binding]; other site 710685012375 Fe binding site [ion binding]; other site 710685012376 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710685012377 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710685012378 active site 710685012379 catalytic triad [active] 710685012380 oxyanion hole [active] 710685012381 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 710685012382 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 710685012383 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 710685012384 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685012385 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685012386 Integrase core domain; Region: rve; pfam00665 710685012387 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685012388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685012389 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710685012390 nudix motif; other site 710685012391 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685012392 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685012393 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685012394 active site 710685012395 ATP binding site [chemical binding]; other site 710685012396 substrate binding site [chemical binding]; other site 710685012397 activation loop (A-loop); other site 710685012398 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710685012399 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 710685012400 FMN-binding pocket [chemical binding]; other site 710685012401 flavin binding motif; other site 710685012402 phosphate binding motif [ion binding]; other site 710685012403 beta-alpha-beta structure motif; other site 710685012404 NAD binding pocket [chemical binding]; other site 710685012405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685012406 catalytic loop [active] 710685012407 iron binding site [ion binding]; other site 710685012408 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710685012409 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710685012410 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685012411 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685012412 putative acyl-acceptor binding pocket; other site 710685012413 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685012414 hydrophobic ligand binding site; other site 710685012415 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 710685012416 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710685012417 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710685012418 active site 710685012419 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710685012420 substrate binding site [chemical binding]; other site 710685012421 catalytic residues [active] 710685012422 dimer interface [polypeptide binding]; other site 710685012423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685012425 protochlorophyllide reductase; Region: PLN00015 710685012426 NAD(P) binding site [chemical binding]; other site 710685012427 active site 710685012428 Domain of unknown function (DUF202); Region: DUF202; cl09954 710685012429 Domain of unknown function (DUF202); Region: DUF202; cl09954 710685012430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012431 putative substrate translocation pore; other site 710685012432 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710685012433 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710685012434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012436 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710685012437 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710685012438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685012439 substrate binding pocket [chemical binding]; other site 710685012440 catalytic triad [active] 710685012441 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 710685012442 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710685012443 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710685012444 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685012445 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685012446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685012448 dimerization interface [polypeptide binding]; other site 710685012449 putative DNA binding site [nucleotide binding]; other site 710685012450 putative Zn2+ binding site [ion binding]; other site 710685012451 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 710685012452 putative hydrophobic ligand binding site [chemical binding]; other site 710685012453 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710685012454 metal binding site [ion binding]; metal-binding site 710685012455 substrate binding site [chemical binding]; other site 710685012456 dimer interface [polypeptide binding]; other site 710685012457 hypothetical protein; Validated; Region: PRK07121 710685012458 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685012459 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710685012460 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710685012461 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710685012462 hypothetical protein; Provisional; Region: PRK06184 710685012463 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685012464 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685012465 hypothetical protein; Provisional; Region: PRK05858 710685012466 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685012467 PYR/PP interface [polypeptide binding]; other site 710685012468 dimer interface [polypeptide binding]; other site 710685012469 TPP binding site [chemical binding]; other site 710685012470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685012471 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710685012472 TPP-binding site; other site 710685012473 dimer interface [polypeptide binding]; other site 710685012474 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 710685012475 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 710685012476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 710685012477 nucleotide binding region [chemical binding]; other site 710685012478 ATP-binding site [chemical binding]; other site 710685012479 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710685012480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710685012481 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710685012482 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 710685012483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710685012484 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710685012485 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 710685012486 lipoyl attachment site [posttranslational modification]; other site 710685012487 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685012488 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685012489 phosphopeptide binding site; other site 710685012490 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 710685012491 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685012492 DNA binding residues [nucleotide binding] 710685012493 Bifunctional nuclease; Region: DNase-RNase; pfam02577 710685012494 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 710685012495 DNA binding residues [nucleotide binding] 710685012496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685012497 putative dimer interface [polypeptide binding]; other site 710685012498 glycine dehydrogenase; Provisional; Region: PRK05367 710685012499 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710685012500 tetramer interface [polypeptide binding]; other site 710685012501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685012502 catalytic residue [active] 710685012503 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710685012504 tetramer interface [polypeptide binding]; other site 710685012505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685012506 catalytic residue [active] 710685012507 haloalkane dehalogenase; Provisional; Region: PRK03204 710685012508 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685012509 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710685012510 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710685012511 metal ion-dependent adhesion site (MIDAS); other site 710685012512 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 710685012513 active site 710685012514 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710685012515 Domain of unknown function DUF21; Region: DUF21; pfam01595 710685012516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710685012517 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710685012518 Domain of unknown function DUF21; Region: DUF21; pfam01595 710685012519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710685012520 Transporter associated domain; Region: CorC_HlyC; smart01091 710685012521 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 710685012522 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710685012523 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710685012524 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710685012525 active site 710685012526 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710685012527 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 710685012528 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 710685012529 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 710685012530 Predicted transcriptional regulator [Transcription]; Region: COG3682 710685012531 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685012532 CoenzymeA binding site [chemical binding]; other site 710685012533 subunit interaction site [polypeptide binding]; other site 710685012534 PHB binding site; other site 710685012535 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 710685012536 alpha-gamma subunit interface [polypeptide binding]; other site 710685012537 beta-gamma subunit interface [polypeptide binding]; other site 710685012538 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 710685012539 alpha-beta subunit interface [polypeptide binding]; other site 710685012540 urease subunit alpha; Reviewed; Region: ureC; PRK13206 710685012541 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 710685012542 subunit interactions [polypeptide binding]; other site 710685012543 active site 710685012544 flap region; other site 710685012545 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 710685012546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685012547 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685012548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685012549 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685012550 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685012551 short chain dehydrogenase; Provisional; Region: PRK12939 710685012552 classical (c) SDRs; Region: SDR_c; cd05233 710685012553 NAD(P) binding site [chemical binding]; other site 710685012554 active site 710685012555 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710685012556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685012557 dimer interface [polypeptide binding]; other site 710685012558 conserved gate region; other site 710685012559 putative PBP binding loops; other site 710685012560 ABC-ATPase subunit interface; other site 710685012561 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 710685012562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685012563 Walker A/P-loop; other site 710685012564 ATP binding site [chemical binding]; other site 710685012565 Q-loop/lid; other site 710685012566 ABC transporter signature motif; other site 710685012567 Walker B; other site 710685012568 D-loop; other site 710685012569 H-loop/switch region; other site 710685012570 TOBE domain; Region: TOBE; pfam03459 710685012571 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 710685012572 Predicted membrane protein [Function unknown]; Region: COG2261 710685012573 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 710685012574 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 710685012575 putative NAD(P) binding site [chemical binding]; other site 710685012576 putative substrate binding site [chemical binding]; other site 710685012577 catalytic Zn binding site [ion binding]; other site 710685012578 structural Zn binding site [ion binding]; other site 710685012579 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710685012580 CGNR zinc finger; Region: zf-CGNR; pfam11706 710685012581 CAAX protease self-immunity; Region: Abi; pfam02517 710685012582 putative phosphoketolase; Provisional; Region: PRK05261 710685012583 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 710685012584 TPP-binding site; other site 710685012585 Src Homology 3 domain superfamily; Region: SH3; cl17036 710685012586 peptide ligand binding site [polypeptide binding]; other site 710685012587 XFP C-terminal domain; Region: XFP_C; pfam09363 710685012588 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685012589 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685012590 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685012591 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012592 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012593 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685012594 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685012595 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710685012596 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685012597 active site 710685012598 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 710685012599 classical (c) SDRs; Region: SDR_c; cd05233 710685012600 NAD(P) binding site [chemical binding]; other site 710685012601 active site 710685012602 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710685012603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685012604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685012605 Protein of unknown function DUF72; Region: DUF72; pfam01904 710685012606 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 710685012607 minor groove reading motif; other site 710685012608 helix-hairpin-helix signature motif; other site 710685012609 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 710685012610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685012611 Walker A motif; other site 710685012612 ATP binding site [chemical binding]; other site 710685012613 Walker B motif; other site 710685012614 arginine finger; other site 710685012615 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710685012616 Predicted esterase [General function prediction only]; Region: COG0627 710685012617 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 710685012618 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710685012619 active site 710685012620 substrate binding site [chemical binding]; other site 710685012621 FMN binding site [chemical binding]; other site 710685012622 putative catalytic residues [active] 710685012623 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710685012624 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710685012625 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685012626 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685012627 ligand binding site [chemical binding]; other site 710685012628 flexible hinge region; other site 710685012629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710685012630 dimerization interface [polypeptide binding]; other site 710685012631 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710685012632 cyclase homology domain; Region: CHD; cd07302 710685012633 nucleotidyl binding site; other site 710685012634 metal binding site [ion binding]; metal-binding site 710685012635 dimer interface [polypeptide binding]; other site 710685012636 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 710685012637 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 710685012638 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710685012639 active site 710685012640 catalytic site [active] 710685012641 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710685012642 nucleoside/Zn binding site; other site 710685012643 dimer interface [polypeptide binding]; other site 710685012644 catalytic motif [active] 710685012645 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685012646 CoenzymeA binding site [chemical binding]; other site 710685012647 subunit interaction site [polypeptide binding]; other site 710685012648 PHB binding site; other site 710685012649 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710685012650 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 710685012651 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710685012652 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 710685012653 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710685012654 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 710685012655 EthD domain; Region: EthD; cl17553 710685012656 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685012657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685012658 phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280 710685012659 substrate binding site [chemical binding]; other site 710685012660 oxyanion hole (OAH) forming residues; other site 710685012661 trimer interface [polypeptide binding]; other site 710685012662 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 710685012663 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 710685012664 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 710685012665 heme binding site [chemical binding]; other site 710685012666 ferroxidase pore; other site 710685012667 ferroxidase diiron center [ion binding]; other site 710685012668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685012669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012670 putative substrate translocation pore; other site 710685012671 CHASE3 domain; Region: CHASE3; pfam05227 710685012672 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710685012673 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685012674 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685012675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685012676 ATP binding site [chemical binding]; other site 710685012677 Walker A/P-loop; other site 710685012678 Q-loop/lid; other site 710685012679 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685012680 anti sigma factor interaction site; other site 710685012681 regulatory phosphorylation site [posttranslational modification]; other site 710685012682 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685012683 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710685012684 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685012685 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685012686 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710685012687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685012688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685012689 short chain dehydrogenase; Provisional; Region: PRK08303 710685012690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685012691 NAD(P) binding site [chemical binding]; other site 710685012692 active site 710685012693 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710685012694 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685012695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685012696 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710685012697 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710685012698 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710685012699 Luciferase helical bundle domain; Region: Luciferase_3H; pfam10284 710685012700 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710685012701 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710685012702 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710685012703 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685012704 active site 710685012705 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710685012706 active site 710685012707 catalytic triad [active] 710685012708 oxyanion hole [active] 710685012709 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710685012710 active site 710685012711 catalytic triad [active] 710685012712 oxyanion hole [active] 710685012713 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710685012714 Chain length determinant protein; Region: Wzz; cl15801 710685012715 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710685012716 Chain length determinant protein; Region: Wzz; cl15801 710685012717 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 710685012718 Glycoside hydrolase family 71; Region: GH71; cd11577 710685012719 putative ligand binding site [chemical binding]; other site 710685012720 putative catalytic site [active] 710685012721 Secretory lipase; Region: LIP; pfam03583 710685012722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685012723 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 710685012724 putative ADP-binding pocket [chemical binding]; other site 710685012725 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 710685012726 putative trimer interface [polypeptide binding]; other site 710685012727 putative active site [active] 710685012728 putative substrate binding site [chemical binding]; other site 710685012729 putative CoA binding site [chemical binding]; other site 710685012730 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 710685012731 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 710685012732 NADP binding site [chemical binding]; other site 710685012733 active site 710685012734 putative substrate binding site [chemical binding]; other site 710685012735 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 710685012736 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 710685012737 NADP-binding site; other site 710685012738 homotetramer interface [polypeptide binding]; other site 710685012739 substrate binding site [chemical binding]; other site 710685012740 homodimer interface [polypeptide binding]; other site 710685012741 active site 710685012742 putative glycosyl transferase; Provisional; Region: PRK10307 710685012743 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 710685012744 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 710685012745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685012746 motif II; other site 710685012747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685012748 Cytochrome P450; Region: p450; cl12078 710685012749 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685012750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685012751 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685012752 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685012753 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685012754 hydrophobic ligand binding site; other site 710685012755 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 710685012756 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685012757 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 710685012758 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685012759 catalytic residues [active] 710685012760 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710685012761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685012762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685012763 putative Zn2+ binding site [ion binding]; other site 710685012764 putative DNA binding site [nucleotide binding]; other site 710685012765 Src homology 2 (SH2) domain; Region: SH2; cl15255 710685012766 phosphotyrosine binding pocket [polypeptide binding]; other site 710685012767 hydrophobic binding pocket [polypeptide binding]; other site 710685012768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710685012769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685012770 Coenzyme A binding pocket [chemical binding]; other site 710685012771 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710685012772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685012773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685012774 S-adenosylmethionine binding site [chemical binding]; other site 710685012775 benzoate transport; Region: 2A0115; TIGR00895 710685012776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685012779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012781 Protein of unknown function, DUF393; Region: DUF393; pfam04134 710685012782 agmatinase; Region: agmatinase; TIGR01230 710685012783 Agmatinase-like family; Region: Agmatinase-like; cd09990 710685012784 active site 710685012785 oligomer interface [polypeptide binding]; other site 710685012786 Mn binding site [ion binding]; other site 710685012787 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710685012788 active site 710685012789 serine racemase; Region: PLN02970 710685012790 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710685012791 tetramer interface [polypeptide binding]; other site 710685012792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685012793 catalytic residue [active] 710685012794 POT family; Region: PTR2; cl17359 710685012795 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 710685012796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685012797 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710685012798 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685012799 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710685012800 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685012801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685012802 DNA-binding site [nucleotide binding]; DNA binding site 710685012803 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710685012804 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710685012805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685012806 non-specific DNA binding site [nucleotide binding]; other site 710685012807 salt bridge; other site 710685012808 sequence-specific DNA binding site [nucleotide binding]; other site 710685012809 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685012810 Cytochrome P450; Region: p450; cl12078 710685012811 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 710685012812 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 710685012813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012815 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685012816 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685012817 molybdopterin cofactor binding site; other site 710685012818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685012819 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710685012820 putative molybdopterin cofactor binding site; other site 710685012821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685012822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685012823 Nitronate monooxygenase; Region: NMO; pfam03060 710685012824 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685012825 FMN binding site [chemical binding]; other site 710685012826 substrate binding site [chemical binding]; other site 710685012827 putative catalytic residue [active] 710685012828 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710685012829 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710685012830 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685012831 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710685012832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685012833 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685012834 NAD(P) binding site [chemical binding]; other site 710685012835 active site 710685012836 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685012837 CoenzymeA binding site [chemical binding]; other site 710685012838 subunit interaction site [polypeptide binding]; other site 710685012839 PHB binding site; other site 710685012840 competence damage-inducible protein A; Provisional; Region: PRK00549 710685012841 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 710685012842 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 710685012843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685012844 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 710685012845 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685012846 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710685012847 dimer interface [polypeptide binding]; other site 710685012848 acyl-activating enzyme (AAE) consensus motif; other site 710685012849 putative active site [active] 710685012850 AMP binding site [chemical binding]; other site 710685012851 putative CoA binding site [chemical binding]; other site 710685012852 hypothetical protein; Validated; Region: PRK02101 710685012853 NlpC/P60 family; Region: NLPC_P60; cl17555 710685012854 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710685012855 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 710685012856 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710685012857 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685012858 cyclase homology domain; Region: CHD; cd07302 710685012859 nucleotidyl binding site; other site 710685012860 metal binding site [ion binding]; metal-binding site 710685012861 dimer interface [polypeptide binding]; other site 710685012862 Predicted ATPase [General function prediction only]; Region: COG3899 710685012863 AAA ATPase domain; Region: AAA_16; pfam13191 710685012864 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685012865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685012866 dimerization interface [polypeptide binding]; other site 710685012867 putative DNA binding site [nucleotide binding]; other site 710685012868 putative Zn2+ binding site [ion binding]; other site 710685012869 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 710685012870 putative hydrophobic ligand binding site [chemical binding]; other site 710685012871 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710685012872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685012873 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685012874 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685012875 active site 710685012876 TDP-binding site; other site 710685012877 acceptor substrate-binding pocket; other site 710685012878 homodimer interface [polypeptide binding]; other site 710685012879 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710685012880 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710685012881 catalytic triad [active] 710685012882 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 710685012883 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 710685012884 heme binding site [chemical binding]; other site 710685012885 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 710685012886 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710685012887 metal binding site 2 [ion binding]; metal-binding site 710685012888 putative DNA binding helix; other site 710685012889 metal binding site 1 [ion binding]; metal-binding site 710685012890 dimer interface [polypeptide binding]; other site 710685012891 structural Zn2+ binding site [ion binding]; other site 710685012892 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685012893 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710685012894 active site 710685012895 catalytic triad [active] 710685012896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685012897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685012898 dimer interface [polypeptide binding]; other site 710685012899 phosphorylation site [posttranslational modification] 710685012900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685012901 ATP binding site [chemical binding]; other site 710685012902 Mg2+ binding site [ion binding]; other site 710685012903 G-X-G motif; other site 710685012904 haloalkane dehalogenase; Provisional; Region: PRK00870 710685012905 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710685012906 tetramer interface [polypeptide binding]; other site 710685012907 active site 710685012908 Mg2+/Mn2+ binding site [ion binding]; other site 710685012909 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 710685012910 Predicted dehydrogenase [General function prediction only]; Region: COG0579 710685012911 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710685012912 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685012913 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685012914 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685012915 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685012917 acyl-activating enzyme (AAE) consensus motif; other site 710685012918 AMP binding site [chemical binding]; other site 710685012919 active site 710685012920 CoA binding site [chemical binding]; other site 710685012921 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685012922 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685012923 active site 710685012924 DJ-1 family protein; Region: not_thiJ; TIGR01383 710685012925 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710685012926 conserved cys residue [active] 710685012927 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 710685012928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710685012929 MOSC domain; Region: MOSC; pfam03473 710685012930 3-alpha domain; Region: 3-alpha; pfam03475 710685012931 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 710685012932 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685012933 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685012934 active site 710685012935 ATP binding site [chemical binding]; other site 710685012936 substrate binding site [chemical binding]; other site 710685012937 activation loop (A-loop); other site 710685012938 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710685012939 DinB superfamily; Region: DinB_2; pfam12867 710685012940 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710685012941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685012942 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685012943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685012944 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685012945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012946 putative substrate translocation pore; other site 710685012947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685012948 Condensation domain; Region: Condensation; pfam00668 710685012949 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710685012950 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685012951 acyl-activating enzyme (AAE) consensus motif; other site 710685012952 AMP binding site [chemical binding]; other site 710685012953 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012954 Condensation domain; Region: Condensation; pfam00668 710685012955 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685012956 Condensation domain; Region: Condensation; pfam00668 710685012957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012959 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710685012960 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 710685012961 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710685012962 acyl-activating enzyme (AAE) consensus motif; other site 710685012963 AMP binding site [chemical binding]; other site 710685012964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012965 Condensation domain; Region: Condensation; pfam00668 710685012966 Condensation domain; Region: Condensation; pfam00668 710685012967 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012968 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012969 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 710685012970 acyl-activating enzyme (AAE) consensus motif; other site 710685012971 AMP binding site [chemical binding]; other site 710685012972 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012973 Condensation domain; Region: Condensation; pfam00668 710685012974 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012975 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710685012976 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 710685012977 acyl-activating enzyme (AAE) consensus motif; other site 710685012978 AMP binding site [chemical binding]; other site 710685012979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685012980 Condensation domain; Region: Condensation; pfam00668 710685012981 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710685012982 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685012983 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710685012984 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 710685012985 putative hydrophobic ligand binding site [chemical binding]; other site 710685012986 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710685012987 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685012988 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685012989 Predicted transcriptional regulator [Transcription]; Region: COG2378 710685012990 HTH domain; Region: HTH_11; pfam08279 710685012991 WYL domain; Region: WYL; pfam13280 710685012992 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 710685012993 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 710685012994 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 710685012995 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 710685012996 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710685012997 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 710685012998 TrkA-N domain; Region: TrkA_N; pfam02254 710685012999 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013001 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685013004 Walker A/P-loop; other site 710685013005 ATP binding site [chemical binding]; other site 710685013006 Q-loop/lid; other site 710685013007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685013008 ABC transporter signature motif; other site 710685013009 Walker B; other site 710685013010 D-loop; other site 710685013011 H-loop/switch region; other site 710685013012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685013013 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 710685013014 Walker A/P-loop; other site 710685013015 ATP binding site [chemical binding]; other site 710685013016 Q-loop/lid; other site 710685013017 ABC transporter signature motif; other site 710685013018 Walker B; other site 710685013019 D-loop; other site 710685013020 H-loop/switch region; other site 710685013021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685013022 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710685013023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685013024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710685013025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685013026 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685013027 Phosphate-starvation-inducible E; Region: PsiE; cl01264 710685013028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685013029 S-adenosylmethionine binding site [chemical binding]; other site 710685013030 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 710685013031 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685013032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685013033 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710685013034 Na binding site [ion binding]; other site 710685013035 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685013036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685013037 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685013038 hydrophobic ligand binding site; other site 710685013039 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710685013040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685013041 Walker A/P-loop; other site 710685013042 ATP binding site [chemical binding]; other site 710685013043 Q-loop/lid; other site 710685013044 ABC transporter signature motif; other site 710685013045 Walker B; other site 710685013046 D-loop; other site 710685013047 H-loop/switch region; other site 710685013048 TOBE domain; Region: TOBE_2; pfam08402 710685013049 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710685013050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710685013051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685013052 dimer interface [polypeptide binding]; other site 710685013053 conserved gate region; other site 710685013054 putative PBP binding loops; other site 710685013055 ABC-ATPase subunit interface; other site 710685013056 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710685013057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685013058 dimer interface [polypeptide binding]; other site 710685013059 conserved gate region; other site 710685013060 putative PBP binding loops; other site 710685013061 ABC-ATPase subunit interface; other site 710685013062 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 710685013063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710685013064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685013065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710685013066 dimerization interface [polypeptide binding]; other site 710685013067 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710685013068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685013069 D-xylulose kinase; Region: XylB; TIGR01312 710685013070 nucleotide binding site [chemical binding]; other site 710685013071 Predicted membrane protein [Function unknown]; Region: COG2259 710685013072 RDD family; Region: RDD; pfam06271 710685013073 GntP family permease; Region: GntP_permease; pfam02447 710685013074 fructuronate transporter; Provisional; Region: PRK10034; cl15264 710685013075 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 710685013076 AAA domain; Region: AAA_33; pfam13671 710685013077 ATP-binding site [chemical binding]; other site 710685013078 Gluconate-6-phosphate binding site [chemical binding]; other site 710685013079 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685013080 FCD domain; Region: FCD; pfam07729 710685013081 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685013082 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685013083 Integrase core domain; Region: rve; pfam00665 710685013084 hypothetical protein; Provisional; Region: PRK02237 710685013085 Ecdysteroid kinase; Region: EcKinase; cl17738 710685013086 Phosphotransferase enzyme family; Region: APH; pfam01636 710685013087 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710685013088 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685013089 substrate binding pocket [chemical binding]; other site 710685013090 catalytic triad [active] 710685013091 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710685013092 Cation efflux family; Region: Cation_efflux; cl00316 710685013093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685013094 dimerization interface [polypeptide binding]; other site 710685013095 putative DNA binding site [nucleotide binding]; other site 710685013096 putative Zn2+ binding site [ion binding]; other site 710685013097 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 710685013098 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 710685013099 active site 710685013100 dimer interface [polypeptide binding]; other site 710685013101 non-prolyl cis peptide bond; other site 710685013102 insertion regions; other site 710685013103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685013104 substrate binding pocket [chemical binding]; other site 710685013105 membrane-bound complex binding site; other site 710685013106 hinge residues; other site 710685013107 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710685013108 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 710685013109 Walker A/P-loop; other site 710685013110 ATP binding site [chemical binding]; other site 710685013111 Q-loop/lid; other site 710685013112 ABC transporter signature motif; other site 710685013113 Walker B; other site 710685013114 D-loop; other site 710685013115 H-loop/switch region; other site 710685013116 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710685013117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685013118 dimer interface [polypeptide binding]; other site 710685013119 conserved gate region; other site 710685013120 putative PBP binding loops; other site 710685013121 ABC-ATPase subunit interface; other site 710685013122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710685013123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710685013124 DNA binding site [nucleotide binding] 710685013125 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710685013126 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685013127 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 710685013128 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 710685013129 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710685013130 Ligand binding site; other site 710685013131 Putative Catalytic site; other site 710685013132 DXD motif; other site 710685013133 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 710685013134 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710685013135 putative active site [active] 710685013136 catalytic triad [active] 710685013137 putative dimer interface [polypeptide binding]; other site 710685013138 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710685013139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685013140 active site 710685013141 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 710685013142 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710685013143 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710685013144 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710685013145 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 710685013146 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710685013147 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710685013148 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013150 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710685013151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685013152 dimer interface [polypeptide binding]; other site 710685013153 conserved gate region; other site 710685013154 putative PBP binding loops; other site 710685013155 ABC-ATPase subunit interface; other site 710685013156 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 710685013157 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710685013158 Walker A/P-loop; other site 710685013159 ATP binding site [chemical binding]; other site 710685013160 Q-loop/lid; other site 710685013161 ABC transporter signature motif; other site 710685013162 Walker B; other site 710685013163 D-loop; other site 710685013164 H-loop/switch region; other site 710685013165 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710685013166 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710685013167 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710685013168 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 710685013169 active site 710685013170 iron coordination sites [ion binding]; other site 710685013171 substrate binding pocket [chemical binding]; other site 710685013172 precorrin-3B synthase; Region: CobG; TIGR02435 710685013173 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710685013174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710685013175 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 710685013176 Precorrin-8X methylmutase; Region: CbiC; pfam02570 710685013177 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 710685013178 active site 710685013179 SAM binding site [chemical binding]; other site 710685013180 homodimer interface [polypeptide binding]; other site 710685013181 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 710685013182 active site 710685013183 SAM binding site [chemical binding]; other site 710685013184 homodimer interface [polypeptide binding]; other site 710685013185 Phosphotransferase enzyme family; Region: APH; pfam01636 710685013186 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710685013187 substrate binding site [chemical binding]; other site 710685013188 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 710685013189 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 710685013190 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 710685013191 active site 710685013192 SAM binding site [chemical binding]; other site 710685013193 homodimer interface [polypeptide binding]; other site 710685013194 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 710685013195 active site 710685013196 putative homodimer interface [polypeptide binding]; other site 710685013197 SAM binding site [chemical binding]; other site 710685013198 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 710685013199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685013200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685013201 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685013202 NAD(P) binding site [chemical binding]; other site 710685013203 active site 710685013204 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685013205 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710685013206 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710685013207 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710685013208 active site 710685013209 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 710685013210 dimer interface [polypeptide binding]; other site 710685013211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685013212 metal binding site [ion binding]; metal-binding site 710685013213 5'-3' exonuclease; Region: 53EXOc; smart00475 710685013214 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710685013215 active site 710685013216 metal binding site 1 [ion binding]; metal-binding site 710685013217 putative 5' ssDNA interaction site; other site 710685013218 metal binding site 3; metal-binding site 710685013219 metal binding site 2 [ion binding]; metal-binding site 710685013220 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710685013221 putative DNA binding site [nucleotide binding]; other site 710685013222 putative metal binding site [ion binding]; other site 710685013223 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710685013224 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 710685013225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685013226 ATP binding site [chemical binding]; other site 710685013227 putative Mg++ binding site [ion binding]; other site 710685013228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685013229 nucleotide binding region [chemical binding]; other site 710685013230 ATP-binding site [chemical binding]; other site 710685013231 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 710685013232 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 710685013233 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 710685013234 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 710685013235 Predicted transcriptional regulator [Transcription]; Region: COG2378 710685013236 WYL domain; Region: WYL; pfam13280 710685013237 Predicted transcriptional regulator [Transcription]; Region: COG2378 710685013238 WYL domain; Region: WYL; pfam13280 710685013239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685013240 S-adenosylmethionine binding site [chemical binding]; other site 710685013241 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 710685013242 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710685013243 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685013244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685013245 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 710685013246 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 710685013247 active site 710685013248 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 710685013249 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710685013250 active site 710685013251 Pup-like protein; Region: Pup; cl05289 710685013252 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 710685013253 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 710685013254 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710685013255 proteasome ATPase; Region: pup_AAA; TIGR03689 710685013256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685013257 Walker A motif; other site 710685013258 ATP binding site [chemical binding]; other site 710685013259 Walker B motif; other site 710685013260 arginine finger; other site 710685013261 Protein of unknown function (DUF503); Region: DUF503; pfam04456 710685013262 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 710685013263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685013264 S-adenosylmethionine binding site [chemical binding]; other site 710685013265 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 710685013266 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685013267 mercuric reductase; Validated; Region: PRK06370 710685013268 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685013269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685013270 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685013271 Predicted membrane protein [Function unknown]; Region: COG3918 710685013272 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 710685013273 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 710685013274 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 710685013275 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 710685013276 homodimer interface [polypeptide binding]; other site 710685013277 putative metal binding site [ion binding]; other site 710685013278 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 710685013279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685013280 putative substrate translocation pore; other site 710685013281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685013282 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710685013283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685013284 motif II; other site 710685013285 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 710685013286 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 710685013287 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 710685013288 substrate binding pocket [chemical binding]; other site 710685013289 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 710685013290 B12 binding site [chemical binding]; other site 710685013291 cobalt ligand [ion binding]; other site 710685013292 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 710685013293 PAC2 family; Region: PAC2; pfam09754 710685013294 Uncharacterized conserved protein [Function unknown]; Region: COG5361 710685013295 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 710685013296 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710685013297 short chain dehydrogenase; Provisional; Region: PRK05872 710685013298 classical (c) SDRs; Region: SDR_c; cd05233 710685013299 NAD(P) binding site [chemical binding]; other site 710685013300 active site 710685013301 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710685013302 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 710685013303 active site 710685013304 HIGH motif; other site 710685013305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710685013306 active site 710685013307 KMSKS motif; other site 710685013308 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 710685013309 putative tRNA binding surface [nucleotide binding]; other site 710685013310 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710685013311 active site 710685013312 conserved hypothetical protein; Region: TIGR03843 710685013313 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 710685013314 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685013315 catalytic core [active] 710685013316 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 710685013317 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 710685013318 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 710685013319 quinone interaction residues [chemical binding]; other site 710685013320 active site 710685013321 catalytic residues [active] 710685013322 FMN binding site [chemical binding]; other site 710685013323 substrate binding site [chemical binding]; other site 710685013324 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710685013325 substrate binding site [chemical binding]; other site 710685013326 hypothetical protein; Provisional; Region: PRK07906 710685013327 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 710685013328 putative metal binding site [ion binding]; other site 710685013329 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710685013330 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 710685013331 catalytic residues [active] 710685013332 catalytic nucleophile [active] 710685013333 Recombinase; Region: Recombinase; pfam07508 710685013334 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 710685013335 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710685013336 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685013337 Creatinine amidohydrolase; Region: Creatininase; pfam02633 710685013338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 710685013339 Transposase; Region: DDE_Tnp_ISL3; pfam01610 710685013340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685013341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685013342 active site 710685013343 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685013344 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685013345 NAD binding site [chemical binding]; other site 710685013346 catalytic Zn binding site [ion binding]; other site 710685013347 substrate binding site [chemical binding]; other site 710685013348 structural Zn binding site [ion binding]; other site 710685013349 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710685013350 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 710685013351 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 710685013352 putative active site [active] 710685013353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685013354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685013355 active site 710685013356 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685013357 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710685013358 dimer interface [polypeptide binding]; other site 710685013359 acyl-activating enzyme (AAE) consensus motif; other site 710685013360 putative active site [active] 710685013361 AMP binding site [chemical binding]; other site 710685013362 putative CoA binding site [chemical binding]; other site 710685013363 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685013364 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710685013365 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 710685013366 Cytochrome P450; Region: p450; cl12078 710685013367 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013369 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685013370 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013372 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013374 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710685013375 classical (c) SDRs; Region: SDR_c; cd05233 710685013376 NAD(P) binding site [chemical binding]; other site 710685013377 active site 710685013378 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710685013379 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710685013380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013381 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 710685013382 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685013383 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710685013384 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685013385 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685013386 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 710685013387 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685013388 carboxyltransferase (CT) interaction site; other site 710685013389 biotinylation site [posttranslational modification]; other site 710685013390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685013391 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685013392 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685013393 active site 710685013394 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710685013395 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685013396 acyl-activating enzyme (AAE) consensus motif; other site 710685013397 AMP binding site [chemical binding]; other site 710685013398 active site 710685013399 CoA binding site [chemical binding]; other site 710685013400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013401 tellurite resistance protein TehB; Provisional; Region: PRK12335 710685013402 TIGR03084 family protein; Region: TIGR03084 710685013403 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685013404 Wyosine base formation; Region: Wyosine_form; pfam08608 710685013405 enoyl-CoA hydratase; Provisional; Region: PRK06494 710685013406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685013407 substrate binding site [chemical binding]; other site 710685013408 oxyanion hole (OAH) forming residues; other site 710685013409 trimer interface [polypeptide binding]; other site 710685013410 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685013411 active site 2 [active] 710685013412 active site 1 [active] 710685013413 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 710685013414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685013415 active site 2 [active] 710685013416 active site 1 [active] 710685013417 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685013418 active site 710685013419 catalytic site [active] 710685013420 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685013421 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685013422 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685013423 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685013424 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685013425 thiolase; Provisional; Region: PRK06158 710685013426 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685013427 active site 710685013428 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 710685013429 Uncharacterized ACR, COG1753; Region: DUF217; cl00762 710685013430 Helix-turn-helix domain; Region: HTH_18; pfam12833 710685013431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685013432 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710685013433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685013434 catalytic loop [active] 710685013435 iron binding site [ion binding]; other site 710685013436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685013437 Cytochrome P450; Region: p450; cl12078 710685013438 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710685013439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685013440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685013441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013443 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685013444 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685013445 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685013446 CoenzymeA binding site [chemical binding]; other site 710685013447 subunit interaction site [polypeptide binding]; other site 710685013448 PHB binding site; other site 710685013449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013451 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710685013452 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685013453 active site 710685013454 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685013455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685013456 NAD(P) binding site [chemical binding]; other site 710685013457 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685013458 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685013459 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 710685013460 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710685013461 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710685013462 D-pathway; other site 710685013463 Putative ubiquinol binding site [chemical binding]; other site 710685013464 Low-spin heme (heme b) binding site [chemical binding]; other site 710685013465 Putative water exit pathway; other site 710685013466 Binuclear center (heme o3/CuB) [ion binding]; other site 710685013467 K-pathway; other site 710685013468 Putative proton exit pathway; other site 710685013469 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 710685013470 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 710685013471 [4Fe-4S] binding site [ion binding]; other site 710685013472 molybdopterin cofactor binding site; other site 710685013473 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 710685013474 molybdopterin cofactor binding site; other site 710685013475 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 710685013476 Flavodoxin; Region: Flavodoxin_1; pfam00258 710685013477 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 710685013478 FAD binding pocket [chemical binding]; other site 710685013479 FAD binding motif [chemical binding]; other site 710685013480 catalytic residues [active] 710685013481 NAD binding pocket [chemical binding]; other site 710685013482 phosphate binding motif [ion binding]; other site 710685013483 beta-alpha-beta structure motif; other site 710685013484 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 710685013485 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685013486 Ligand Binding Site [chemical binding]; other site 710685013487 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 710685013488 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 710685013489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 710685013490 PAS domain; Region: PAS; smart00091 710685013491 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 710685013492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685013493 ATP binding site [chemical binding]; other site 710685013494 Mg2+ binding site [ion binding]; other site 710685013495 G-X-G motif; other site 710685013496 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710685013497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685013498 active site 710685013499 phosphorylation site [posttranslational modification] 710685013500 intermolecular recognition site; other site 710685013501 dimerization interface [polypeptide binding]; other site 710685013502 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685013503 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685013504 active site 710685013505 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 710685013506 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 710685013507 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 710685013508 substrate binding site [chemical binding]; other site 710685013509 active site 710685013510 catalytic residues [active] 710685013511 heterodimer interface [polypeptide binding]; other site 710685013512 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 710685013513 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 710685013514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685013515 catalytic residue [active] 710685013516 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 710685013517 active site 710685013518 ribulose/triose binding site [chemical binding]; other site 710685013519 phosphate binding site [ion binding]; other site 710685013520 substrate (anthranilate) binding pocket [chemical binding]; other site 710685013521 product (indole) binding pocket [chemical binding]; other site 710685013522 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 710685013523 anthranilate synthase component I; Provisional; Region: PRK13571 710685013524 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 710685013525 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710685013526 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710685013527 catalytic triad [active] 710685013528 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685013529 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685013530 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 710685013531 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 710685013532 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710685013533 substrate binding site [chemical binding]; other site 710685013534 glutamase interaction surface [polypeptide binding]; other site 710685013535 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710685013536 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 710685013537 active site 710685013538 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 710685013539 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710685013540 catalytic residues [active] 710685013541 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 710685013542 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 710685013543 putative active site [active] 710685013544 oxyanion strand; other site 710685013545 catalytic triad [active] 710685013546 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 710685013547 putative active site pocket [active] 710685013548 4-fold oligomerization interface [polypeptide binding]; other site 710685013549 metal binding residues [ion binding]; metal-binding site 710685013550 3-fold/trimer interface [polypeptide binding]; other site 710685013551 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 710685013552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685013553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685013554 homodimer interface [polypeptide binding]; other site 710685013555 catalytic residue [active] 710685013556 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 710685013557 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 710685013558 NAD binding site [chemical binding]; other site 710685013559 dimerization interface [polypeptide binding]; other site 710685013560 product binding site; other site 710685013561 substrate binding site [chemical binding]; other site 710685013562 zinc binding site [ion binding]; other site 710685013563 catalytic residues [active] 710685013564 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685013565 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685013566 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685013567 NAD(P) binding site [chemical binding]; other site 710685013568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013570 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 710685013571 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 710685013572 dimerization interface [polypeptide binding]; other site 710685013573 active site 710685013574 L-aspartate oxidase; Provisional; Region: PRK07804 710685013575 L-aspartate oxidase; Provisional; Region: PRK06175 710685013576 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710685013577 quinolinate synthetase; Provisional; Region: PRK09375 710685013578 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 710685013579 nudix motif; other site 710685013580 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 710685013581 Secretory lipase; Region: LIP; pfam03583 710685013582 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 710685013583 biotin synthase; Validated; Region: PRK06256 710685013584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685013585 FeS/SAM binding site; other site 710685013586 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 710685013587 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685013588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013589 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685013590 Protein of unknown function (DUF419); Region: DUF419; cl15265 710685013591 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710685013592 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710685013593 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 710685013594 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 710685013595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685013596 catalytic residue [active] 710685013597 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 710685013598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685013599 inhibitor-cofactor binding pocket; inhibition site 710685013600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685013601 catalytic residue [active] 710685013602 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710685013603 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710685013604 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710685013605 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710685013606 active site 710685013607 catalytic site [active] 710685013608 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 710685013609 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 710685013610 active site 710685013611 catalytic site [active] 710685013612 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 710685013613 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 710685013614 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 710685013615 catalytic site [active] 710685013616 active site 710685013617 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710685013618 threonine dehydratase; Validated; Region: PRK08639 710685013619 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710685013620 tetramer interface [polypeptide binding]; other site 710685013621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685013622 catalytic residue [active] 710685013623 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 710685013624 putative Ile/Val binding site [chemical binding]; other site 710685013625 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685013626 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685013627 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710685013628 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710685013629 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710685013630 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710685013631 tetramer interface [polypeptide binding]; other site 710685013632 active site 710685013633 Mg2+/Mn2+ binding site [ion binding]; other site 710685013634 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 710685013635 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 710685013636 active site 710685013637 PHP Thumb interface [polypeptide binding]; other site 710685013638 metal binding site [ion binding]; metal-binding site 710685013639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710685013640 generic binding surface II; other site 710685013641 generic binding surface I; other site 710685013642 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685013643 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685013644 Predicted transcriptional regulators [Transcription]; Region: COG1733 710685013645 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710685013646 Predicted permeases [General function prediction only]; Region: RarD; COG2962 710685013647 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710685013648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710685013649 active site 710685013650 lipoprotein signal peptidase; Provisional; Region: PRK14764 710685013651 lipoprotein signal peptidase; Provisional; Region: PRK14787 710685013652 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 710685013653 active site 710685013654 homodimer interface [polypeptide binding]; other site 710685013655 homotetramer interface [polypeptide binding]; other site 710685013656 DNA polymerase IV; Provisional; Region: PRK03348 710685013657 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710685013658 active site 710685013659 DNA binding site [nucleotide binding] 710685013660 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710685013661 dinuclear metal binding motif [ion binding]; other site 710685013662 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 710685013663 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685013664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710685013665 RNA binding surface [nucleotide binding]; other site 710685013666 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 710685013667 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710685013668 HIGH motif; other site 710685013669 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710685013670 active site 710685013671 KMSKS motif; other site 710685013672 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 710685013673 tRNA binding surface [nucleotide binding]; other site 710685013674 anticodon binding site; other site 710685013675 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710685013676 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685013677 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685013678 membrane ATPase/protein kinase; Provisional; Region: PRK09435 710685013679 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 710685013680 Walker A; other site 710685013681 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710685013682 G4 box; other site 710685013683 G5 box; other site 710685013684 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 710685013685 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 710685013686 active site 710685013687 substrate binding site [chemical binding]; other site 710685013688 coenzyme B12 binding site [chemical binding]; other site 710685013689 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710685013690 B12 binding site [chemical binding]; other site 710685013691 cobalt ligand [ion binding]; other site 710685013692 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 710685013693 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 710685013694 heterodimer interface [polypeptide binding]; other site 710685013695 substrate interaction site [chemical binding]; other site 710685013696 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710685013697 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710685013698 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710685013699 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685013700 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685013701 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710685013702 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710685013703 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 710685013704 ferrochelatase; Reviewed; Region: hemH; PRK00035 710685013705 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 710685013706 C-terminal domain interface [polypeptide binding]; other site 710685013707 active site 710685013708 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 710685013709 active site 710685013710 N-terminal domain interface [polypeptide binding]; other site 710685013711 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 710685013712 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 710685013713 NAD binding site [chemical binding]; other site 710685013714 homotetramer interface [polypeptide binding]; other site 710685013715 homodimer interface [polypeptide binding]; other site 710685013716 substrate binding site [chemical binding]; other site 710685013717 active site 710685013718 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 710685013719 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710685013720 NAD(P) binding site [chemical binding]; other site 710685013721 homotetramer interface [polypeptide binding]; other site 710685013722 homodimer interface [polypeptide binding]; other site 710685013723 active site 710685013724 hypothetical protein; Provisional; Region: PRK13685 710685013725 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710685013726 metal ion-dependent adhesion site (MIDAS); other site 710685013727 hypothetical protein; Provisional; Region: PRK13685 710685013728 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 710685013729 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710685013730 metal ion-dependent adhesion site (MIDAS); other site 710685013731 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710685013732 Protein of unknown function DUF58; Region: DUF58; pfam01882 710685013733 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685013734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685013735 Walker A motif; other site 710685013736 ATP binding site [chemical binding]; other site 710685013737 Walker B motif; other site 710685013738 arginine finger; other site 710685013739 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685013740 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685013741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 710685013742 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710685013743 NlpC/P60 family; Region: NLPC_P60; pfam00877 710685013744 aconitate hydratase; Validated; Region: PRK09277 710685013745 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710685013746 substrate binding site [chemical binding]; other site 710685013747 ligand binding site [chemical binding]; other site 710685013748 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 710685013749 substrate binding site [chemical binding]; other site 710685013750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013752 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710685013753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685013754 Walker A/P-loop; other site 710685013755 ATP binding site [chemical binding]; other site 710685013756 Q-loop/lid; other site 710685013757 ABC transporter signature motif; other site 710685013758 Walker B; other site 710685013759 D-loop; other site 710685013760 H-loop/switch region; other site 710685013761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710685013762 enoyl-CoA hydratase; Provisional; Region: PRK05864 710685013763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685013764 substrate binding site [chemical binding]; other site 710685013765 oxyanion hole (OAH) forming residues; other site 710685013766 trimer interface [polypeptide binding]; other site 710685013767 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 710685013768 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710685013769 catalytic residues [active] 710685013770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710685013771 MOSC domain; Region: MOSC; pfam03473 710685013772 3-alpha domain; Region: 3-alpha; pfam03475 710685013773 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 710685013774 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710685013775 FAD binding pocket [chemical binding]; other site 710685013776 FAD binding motif [chemical binding]; other site 710685013777 phosphate binding motif [ion binding]; other site 710685013778 beta-alpha-beta structure motif; other site 710685013779 NAD binding pocket [chemical binding]; other site 710685013780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710685013781 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710685013782 catalytic loop [active] 710685013783 iron binding site [ion binding]; other site 710685013784 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710685013785 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710685013786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685013787 active site 710685013788 motif II; other site 710685013789 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710685013790 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 710685013791 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710685013792 trimerization site [polypeptide binding]; other site 710685013793 active site 710685013794 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710685013795 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 710685013796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685013797 catalytic residue [active] 710685013798 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 710685013799 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 710685013800 Walker A/P-loop; other site 710685013801 ATP binding site [chemical binding]; other site 710685013802 Q-loop/lid; other site 710685013803 ABC transporter signature motif; other site 710685013804 Walker B; other site 710685013805 D-loop; other site 710685013806 H-loop/switch region; other site 710685013807 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 710685013808 FeS assembly protein SufD; Region: sufD; TIGR01981 710685013809 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710685013810 FeS assembly protein SufB; Region: sufB; TIGR01980 710685013811 Predicted transcriptional regulator [Transcription]; Region: COG2345 710685013812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685013813 dimerization interface [polypeptide binding]; other site 710685013814 putative DNA binding site [nucleotide binding]; other site 710685013815 putative Zn2+ binding site [ion binding]; other site 710685013816 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 710685013817 Prostaglandin dehydrogenases; Region: PGDH; cd05288 710685013818 NAD(P) binding site [chemical binding]; other site 710685013819 substrate binding site [chemical binding]; other site 710685013820 dimer interface [polypeptide binding]; other site 710685013821 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710685013822 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710685013823 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710685013824 Walker A/P-loop; other site 710685013825 ATP binding site [chemical binding]; other site 710685013826 Q-loop/lid; other site 710685013827 ABC transporter signature motif; other site 710685013828 Walker B; other site 710685013829 D-loop; other site 710685013830 H-loop/switch region; other site 710685013831 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710685013832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013834 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 710685013835 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 710685013836 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685013837 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 710685013838 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 710685013839 NADP binding site [chemical binding]; other site 710685013840 dimer interface [polypeptide binding]; other site 710685013841 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 710685013842 UbiA prenyltransferase family; Region: UbiA; pfam01040 710685013843 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 710685013844 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710685013845 TPP-binding site [chemical binding]; other site 710685013846 dimer interface [polypeptide binding]; other site 710685013847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710685013848 PYR/PP interface [polypeptide binding]; other site 710685013849 dimer interface [polypeptide binding]; other site 710685013850 TPP binding site [chemical binding]; other site 710685013851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685013852 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710685013853 putative active site [active] 710685013854 transaldolase; Provisional; Region: PRK03903 710685013855 catalytic residue [active] 710685013856 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 710685013857 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710685013858 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710685013859 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 710685013860 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 710685013861 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710685013862 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 710685013863 putative active site [active] 710685013864 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685013865 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685013866 active site 710685013867 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685013868 Cytochrome P450; Region: p450; cl12078 710685013869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685013870 classical (c) SDRs; Region: SDR_c; cd05233 710685013871 NAD(P) binding site [chemical binding]; other site 710685013872 active site 710685013873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685013874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685013875 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 710685013876 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 710685013877 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710685013878 triosephosphate isomerase; Provisional; Region: PRK14565 710685013879 substrate binding site [chemical binding]; other site 710685013880 dimer interface [polypeptide binding]; other site 710685013881 catalytic triad [active] 710685013882 Phosphoglycerate kinase; Region: PGK; pfam00162 710685013883 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 710685013884 substrate binding site [chemical binding]; other site 710685013885 hinge regions; other site 710685013886 ADP binding site [chemical binding]; other site 710685013887 catalytic site [active] 710685013888 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 710685013889 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 710685013890 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710685013891 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685013892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685013893 substrate binding pocket [chemical binding]; other site 710685013894 membrane-bound complex binding site; other site 710685013895 hinge residues; other site 710685013896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685013897 cyclase homology domain; Region: CHD; cd07302 710685013898 nucleotidyl binding site; other site 710685013899 metal binding site [ion binding]; metal-binding site 710685013900 dimer interface [polypeptide binding]; other site 710685013901 Predicted ATPase [General function prediction only]; Region: COG3903 710685013902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710685013903 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 710685013904 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 710685013905 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 710685013906 phosphate binding site [ion binding]; other site 710685013907 putative substrate binding pocket [chemical binding]; other site 710685013908 dimer interface [polypeptide binding]; other site 710685013909 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 710685013910 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710685013911 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710685013912 GIY-YIG motif/motif A; other site 710685013913 active site 710685013914 catalytic site [active] 710685013915 putative DNA binding site [nucleotide binding]; other site 710685013916 metal binding site [ion binding]; metal-binding site 710685013917 UvrB/uvrC motif; Region: UVR; pfam02151 710685013918 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710685013919 Helix-hairpin-helix motif; Region: HHH; pfam00633 710685013920 helix-hairpin-helix signature motif; other site 710685013921 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 710685013922 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 710685013923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710685013924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685013925 Coenzyme A binding pocket [chemical binding]; other site 710685013926 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710685013927 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 710685013928 homopentamer interface [polypeptide binding]; other site 710685013929 active site 710685013930 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 710685013931 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710685013932 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710685013933 dimerization interface [polypeptide binding]; other site 710685013934 active site 710685013935 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685013936 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 710685013937 Lumazine binding domain; Region: Lum_binding; pfam00677 710685013938 Lumazine binding domain; Region: Lum_binding; pfam00677 710685013939 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 710685013940 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685013941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685013942 putative substrate translocation pore; other site 710685013943 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 710685013944 intracellular protease, PfpI family; Region: PfpI; TIGR01382 710685013945 proposed catalytic triad [active] 710685013946 conserved cys residue [active] 710685013947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710685013948 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710685013949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710685013950 Walker A/P-loop; other site 710685013951 ATP binding site [chemical binding]; other site 710685013952 Q-loop/lid; other site 710685013953 ABC transporter signature motif; other site 710685013954 Walker B; other site 710685013955 D-loop; other site 710685013956 H-loop/switch region; other site 710685013957 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710685013958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710685013959 ligand binding site [chemical binding]; other site 710685013960 flexible hinge region; other site 710685013961 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 710685013962 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 710685013963 catalytic motif [active] 710685013964 Zn binding site [ion binding]; other site 710685013965 RibD C-terminal domain; Region: RibD_C; pfam01872 710685013966 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 710685013967 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 710685013968 substrate binding site [chemical binding]; other site 710685013969 hexamer interface [polypeptide binding]; other site 710685013970 metal binding site [ion binding]; metal-binding site 710685013971 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 710685013972 putative RNA binding site [nucleotide binding]; other site 710685013973 16S rRNA methyltransferase B; Provisional; Region: PRK14902 710685013974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685013975 S-adenosylmethionine binding site [chemical binding]; other site 710685013976 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710685013977 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710685013978 putative active site [active] 710685013979 substrate binding site [chemical binding]; other site 710685013980 putative cosubstrate binding site; other site 710685013981 catalytic site [active] 710685013982 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710685013983 substrate binding site [chemical binding]; other site 710685013984 LemA family; Region: LemA; cl00742 710685013985 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 710685013986 primosome assembly protein PriA; Provisional; Region: PRK14873 710685013987 Predicted membrane protein [Function unknown]; Region: COG3714 710685013988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685013989 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685013990 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685013991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685013992 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710685013993 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710685013994 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710685013995 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710685013996 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 710685013997 Flavoprotein; Region: Flavoprotein; pfam02441 710685013998 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 710685013999 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 710685014000 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 710685014001 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 710685014002 catalytic site [active] 710685014003 G-X2-G-X-G-K; other site 710685014004 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 710685014005 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 710685014006 active site 710685014007 dimer interface [polypeptide binding]; other site 710685014008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 710685014009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685014010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685014011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 710685014012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685014013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685014014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 710685014015 IMP binding site; other site 710685014016 dimer interface [polypeptide binding]; other site 710685014017 interdomain contacts; other site 710685014018 partial ornithine binding site; other site 710685014019 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 710685014020 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 710685014021 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 710685014022 catalytic site [active] 710685014023 subunit interface [polypeptide binding]; other site 710685014024 dihydroorotase; Validated; Region: pyrC; PRK09357 710685014025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685014026 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 710685014027 active site 710685014028 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 710685014029 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710685014030 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710685014031 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 710685014032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685014033 active site 710685014034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710685014035 Beta-lactamase; Region: Beta-lactamase; pfam00144 710685014036 hypothetical protein; Provisional; Region: PRK07236 710685014037 hypothetical protein; Provisional; Region: PRK07588 710685014038 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685014039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710685014040 Helix-turn-helix domain; Region: HTH_38; pfam13936 710685014041 Integrase core domain; Region: rve; pfam00665 710685014042 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 710685014043 putative RNA binding site [nucleotide binding]; other site 710685014044 elongation factor P; Validated; Region: PRK00529 710685014045 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710685014046 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 710685014047 RNA binding site [nucleotide binding]; other site 710685014048 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 710685014049 RNA binding site [nucleotide binding]; other site 710685014050 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710685014051 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710685014052 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710685014053 active site 710685014054 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 710685014055 Dehydroquinase class II; Region: DHquinase_II; pfam01220 710685014056 trimer interface [polypeptide binding]; other site 710685014057 active site 710685014058 dimer interface [polypeptide binding]; other site 710685014059 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 710685014060 active site 710685014061 dimer interface [polypeptide binding]; other site 710685014062 metal binding site [ion binding]; metal-binding site 710685014063 shikimate kinase; Reviewed; Region: aroK; PRK00131 710685014064 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 710685014065 ADP binding site [chemical binding]; other site 710685014066 magnesium binding site [ion binding]; other site 710685014067 putative shikimate binding site; other site 710685014068 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 710685014069 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 710685014070 Tetramer interface [polypeptide binding]; other site 710685014071 active site 710685014072 FMN-binding site [chemical binding]; other site 710685014073 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 710685014074 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710685014075 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 710685014076 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710685014077 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 710685014078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685014079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014080 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 710685014081 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685014082 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 710685014083 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 710685014084 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710685014085 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710685014086 shikimate binding site; other site 710685014087 NAD(P) binding site [chemical binding]; other site 710685014088 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 710685014089 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 710685014090 dimerization interface [polypeptide binding]; other site 710685014091 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 710685014092 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710685014093 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 710685014094 motif 1; other site 710685014095 active site 710685014096 motif 2; other site 710685014097 motif 3; other site 710685014098 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710685014099 DHHA1 domain; Region: DHHA1; pfam02272 710685014100 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 710685014101 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 710685014102 putative hydrophobic ligand binding site [chemical binding]; other site 710685014103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685014104 putative DNA binding site [nucleotide binding]; other site 710685014105 putative Zn2+ binding site [ion binding]; other site 710685014106 recombination factor protein RarA; Reviewed; Region: PRK13342 710685014107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685014108 Walker A motif; other site 710685014109 ATP binding site [chemical binding]; other site 710685014110 Walker B motif; other site 710685014111 arginine finger; other site 710685014112 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 710685014113 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 710685014114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 710685014115 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 710685014116 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685014117 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710685014118 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710685014119 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 710685014120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710685014121 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710685014122 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710685014123 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710685014124 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710685014125 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 710685014126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 710685014127 Domain of unknown function (DUF389); Region: DUF389; cl00781 710685014128 Predicted transcriptional regulators [Transcription]; Region: COG1733 710685014129 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710685014130 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710685014131 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685014132 dimer interface [polypeptide binding]; other site 710685014133 active site 710685014134 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685014135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685014136 short chain dehydrogenase; Provisional; Region: PRK06197 710685014137 NAD(P) binding site [chemical binding]; other site 710685014138 active site 710685014139 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710685014140 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 710685014141 dimer interface [polypeptide binding]; other site 710685014142 anticodon binding site; other site 710685014143 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 710685014144 homodimer interface [polypeptide binding]; other site 710685014145 motif 1; other site 710685014146 active site 710685014147 motif 2; other site 710685014148 GAD domain; Region: GAD; pfam02938 710685014149 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710685014150 active site 710685014151 motif 3; other site 710685014152 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 710685014153 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710685014154 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710685014155 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710685014156 putative hydrophobic ligand binding site [chemical binding]; other site 710685014157 protein interface [polypeptide binding]; other site 710685014158 gate; other site 710685014159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685014160 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710685014161 substrate binding pocket [chemical binding]; other site 710685014162 catalytic triad [active] 710685014163 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710685014164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685014165 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685014166 classical (c) SDRs; Region: SDR_c; cd05233 710685014167 NAD(P) binding site [chemical binding]; other site 710685014168 active site 710685014169 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685014170 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685014171 active site 710685014172 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685014173 catalytic triad [active] 710685014174 dimer interface [polypeptide binding]; other site 710685014175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685014176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014177 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685014178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685014179 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685014180 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685014181 active site 710685014182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685014183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685014184 active site 710685014185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710685014186 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710685014187 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710685014188 Radical SAM superfamily; Region: Radical_SAM; pfam04055 710685014189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685014190 FeS/SAM binding site; other site 710685014191 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685014192 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710685014193 homodimer interface [polypeptide binding]; other site 710685014194 active site 710685014195 TDP-binding site; other site 710685014196 acceptor substrate-binding pocket; other site 710685014197 probable selenate reductase, molybdenum-binding subunit; Region: Se_sel_red_Mo; TIGR03313 710685014198 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710685014199 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 710685014200 putative ligand binding site [chemical binding]; other site 710685014201 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710685014202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710685014203 TM-ABC transporter signature motif; other site 710685014204 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710685014205 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710685014206 TM-ABC transporter signature motif; other site 710685014207 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 710685014208 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710685014209 Walker A/P-loop; other site 710685014210 ATP binding site [chemical binding]; other site 710685014211 Q-loop/lid; other site 710685014212 ABC transporter signature motif; other site 710685014213 Walker B; other site 710685014214 D-loop; other site 710685014215 H-loop/switch region; other site 710685014216 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 710685014217 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710685014218 Walker A/P-loop; other site 710685014219 ATP binding site [chemical binding]; other site 710685014220 Q-loop/lid; other site 710685014221 ABC transporter signature motif; other site 710685014222 Walker B; other site 710685014223 D-loop; other site 710685014224 H-loop/switch region; other site 710685014225 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710685014226 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710685014227 RibD C-terminal domain; Region: RibD_C; cl17279 710685014228 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710685014229 PAS domain; Region: PAS; smart00091 710685014230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710685014231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710685014232 metal binding site [ion binding]; metal-binding site 710685014233 active site 710685014234 I-site; other site 710685014235 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 710685014236 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 710685014237 dimer interface [polypeptide binding]; other site 710685014238 motif 1; other site 710685014239 active site 710685014240 motif 2; other site 710685014241 motif 3; other site 710685014242 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 710685014243 anticodon binding site; other site 710685014244 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710685014245 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710685014246 active site 710685014247 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710685014248 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710685014249 active site 710685014250 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710685014251 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 710685014252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685014253 Zn2+ binding site [ion binding]; other site 710685014254 Mg2+ binding site [ion binding]; other site 710685014255 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710685014256 synthetase active site [active] 710685014257 NTP binding site [chemical binding]; other site 710685014258 metal binding site [ion binding]; metal-binding site 710685014259 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 710685014260 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 710685014261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685014262 active site 710685014263 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710685014264 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710685014265 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 710685014266 Protein export membrane protein; Region: SecD_SecF; pfam02355 710685014267 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 710685014268 Protein export membrane protein; Region: SecD_SecF; cl14618 710685014269 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 710685014270 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685014271 active site 710685014272 metal binding site [ion binding]; metal-binding site 710685014273 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 710685014274 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710685014275 inhibitor-cofactor binding pocket; inhibition site 710685014276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685014277 catalytic residue [active] 710685014278 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710685014279 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 710685014280 tetrameric interface [polypeptide binding]; other site 710685014281 NAD binding site [chemical binding]; other site 710685014282 catalytic residues [active] 710685014283 substrate binding site [chemical binding]; other site 710685014284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685014285 MarR family; Region: MarR_2; pfam12802 710685014286 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710685014287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685014288 acyl-activating enzyme (AAE) consensus motif; other site 710685014289 AMP binding site [chemical binding]; other site 710685014290 active site 710685014291 CoA binding site [chemical binding]; other site 710685014292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685014293 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710685014294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685014295 NAD(P) binding site [chemical binding]; other site 710685014296 active site 710685014297 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 710685014298 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710685014299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685014300 Walker A motif; other site 710685014301 ATP binding site [chemical binding]; other site 710685014302 Walker B motif; other site 710685014303 arginine finger; other site 710685014304 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710685014305 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710685014306 RuvA N terminal domain; Region: RuvA_N; pfam01330 710685014307 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 710685014308 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 710685014309 active site 710685014310 putative DNA-binding cleft [nucleotide binding]; other site 710685014311 dimer interface [polypeptide binding]; other site 710685014312 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710685014313 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710685014314 hypothetical protein; Validated; Region: PRK00110 710685014315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685014316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014317 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 710685014318 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 710685014319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685014320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685014321 active site 710685014322 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 710685014323 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 710685014324 predicted active site [active] 710685014325 catalytic triad [active] 710685014326 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710685014327 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685014328 active site 710685014329 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685014330 catalytic triad [active] 710685014331 dimer interface [polypeptide binding]; other site 710685014332 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 710685014333 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 710685014334 active site 710685014335 multimer interface [polypeptide binding]; other site 710685014336 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 710685014337 nudix motif; other site 710685014338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685014339 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685014340 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 710685014341 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 710685014342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 710685014343 putative acyl-acceptor binding pocket; other site 710685014344 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710685014345 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 710685014346 nucleotide binding site/active site [active] 710685014347 HIT family signature motif; other site 710685014348 catalytic residue [active] 710685014349 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710685014350 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710685014351 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710685014352 active site 710685014353 dimer interface [polypeptide binding]; other site 710685014354 motif 1; other site 710685014355 motif 2; other site 710685014356 motif 3; other site 710685014357 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710685014358 anticodon binding site; other site 710685014359 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 710685014360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685014361 CoenzymeA binding site [chemical binding]; other site 710685014362 subunit interaction site [polypeptide binding]; other site 710685014363 PHB binding site; other site 710685014364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685014365 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685014366 active site 710685014367 catalytic tetrad [active] 710685014368 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 710685014369 GAF domain; Region: GAF_2; pfam13185 710685014370 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685014371 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710685014372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710685014373 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710685014374 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685014375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685014376 putative substrate translocation pore; other site 710685014377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685014378 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710685014379 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710685014380 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 710685014381 GAF domain; Region: GAF; pfam01590 710685014382 GAF domain; Region: GAF_2; pfam13185 710685014383 ANTAR domain; Region: ANTAR; pfam03861 710685014384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710685014385 Helix-turn-helix domain; Region: HTH_18; pfam12833 710685014386 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685014387 hydrophobic ligand binding site; other site 710685014388 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 710685014389 Clp amino terminal domain; Region: Clp_N; pfam02861 710685014390 Clp amino terminal domain; Region: Clp_N; pfam02861 710685014391 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710685014392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685014393 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710685014394 DNA binding residues [nucleotide binding] 710685014395 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 710685014396 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710685014397 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710685014398 DNA binding site [nucleotide binding] 710685014399 active site 710685014400 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710685014401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 710685014402 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710685014403 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 710685014404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710685014405 Walker A motif; other site 710685014406 ATP binding site [chemical binding]; other site 710685014407 Walker B motif; other site 710685014408 hypothetical protein; Provisional; Region: PRK14059 710685014409 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710685014410 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685014411 TAP-like protein; Region: Abhydrolase_4; pfam08386 710685014412 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710685014413 Phosphotransferase enzyme family; Region: APH; pfam01636 710685014414 Ecdysteroid kinase; Region: EcKinase; cl17738 710685014415 Double zinc ribbon; Region: DZR; pfam12773 710685014416 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710685014417 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 710685014418 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710685014419 cyclase homology domain; Region: CHD; cd07302 710685014420 nucleotidyl binding site; other site 710685014421 metal binding site [ion binding]; metal-binding site 710685014422 dimer interface [polypeptide binding]; other site 710685014423 AAA ATPase domain; Region: AAA_16; pfam13191 710685014424 AAA domain; Region: AAA_22; pfam13401 710685014425 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685014426 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685014427 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685014428 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 710685014429 SelR domain; Region: SelR; pfam01641 710685014430 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 710685014431 malate dehydrogenase; Provisional; Region: PRK13529 710685014432 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710685014433 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 710685014434 NAD(P) binding pocket [chemical binding]; other site 710685014435 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 710685014436 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 710685014437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685014438 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 710685014439 substrate binding site [chemical binding]; other site 710685014440 active site 710685014441 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 710685014442 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 710685014443 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 710685014444 catalytic site [active] 710685014445 putative active site [active] 710685014446 putative substrate binding site [chemical binding]; other site 710685014447 Helicase and RNase D C-terminal; Region: HRDC; smart00341 710685014448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685014449 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 710685014450 putative active site [active] 710685014451 putative metal binding site [ion binding]; other site 710685014452 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710685014453 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710685014454 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 710685014455 TPP-binding site; other site 710685014456 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710685014457 PYR/PP interface [polypeptide binding]; other site 710685014458 dimer interface [polypeptide binding]; other site 710685014459 TPP binding site [chemical binding]; other site 710685014460 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685014461 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 710685014462 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685014463 TRAM domain; Region: TRAM; pfam01938 710685014464 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 710685014465 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710685014466 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710685014467 TrkA-N domain; Region: TrkA_N; pfam02254 710685014468 TrkA-N domain; Region: TrkA_N; pfam02254 710685014469 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710685014470 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685014471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685014472 putative substrate translocation pore; other site 710685014473 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 710685014474 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710685014475 generic binding surface II; other site 710685014476 ssDNA binding site; other site 710685014477 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 710685014478 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710685014479 trimer interface [polypeptide binding]; other site 710685014480 active site 710685014481 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 710685014482 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710685014483 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710685014484 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 710685014485 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710685014486 active site 710685014487 dimerization interface [polypeptide binding]; other site 710685014488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710685014489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710685014490 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710685014491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685014492 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710685014493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685014494 DNA binding residues [nucleotide binding] 710685014495 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 710685014496 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710685014497 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710685014498 DNA binding residues [nucleotide binding] 710685014499 TOBE domain; Region: TOBE; cl01440 710685014500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685014501 S-adenosylmethionine binding site [chemical binding]; other site 710685014502 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 710685014503 homotrimer interaction site [polypeptide binding]; other site 710685014504 putative active site [active] 710685014505 Protein of unknown function (DUF952); Region: DUF952; cl01393 710685014506 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 710685014507 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 710685014508 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 710685014509 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710685014510 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 710685014511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685014512 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710685014513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685014514 DNA binding residues [nucleotide binding] 710685014515 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710685014516 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 710685014517 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710685014518 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 710685014519 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710685014520 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 710685014521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685014522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685014523 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685014524 PAC2 family; Region: PAC2; pfam09754 710685014525 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685014526 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685014527 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 710685014528 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 710685014529 ATP cone domain; Region: ATP-cone; pfam03477 710685014530 LexA repressor; Validated; Region: PRK00215 710685014531 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 710685014532 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 710685014533 Catalytic site [active] 710685014534 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710685014535 LGFP repeat; Region: LGFP; pfam08310 710685014536 LGFP repeat; Region: LGFP; pfam08310 710685014537 LGFP repeat; Region: LGFP; pfam08310 710685014538 LGFP repeat; Region: LGFP; pfam08310 710685014539 LGFP repeat; Region: LGFP; pfam08310 710685014540 GTPases [General function prediction only]; Region: HflX; COG2262 710685014541 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 710685014542 HflX GTPase family; Region: HflX; cd01878 710685014543 G1 box; other site 710685014544 GTP/Mg2+ binding site [chemical binding]; other site 710685014545 Switch I region; other site 710685014546 G2 box; other site 710685014547 G3 box; other site 710685014548 Switch II region; other site 710685014549 G4 box; other site 710685014550 G5 box; other site 710685014551 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 710685014552 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710685014553 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710685014554 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 710685014555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685014556 Walker A motif; other site 710685014557 ATP binding site [chemical binding]; other site 710685014558 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 710685014559 active site 710685014560 metal binding site [ion binding]; metal-binding site 710685014561 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710685014562 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710685014563 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710685014564 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 710685014565 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 710685014566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685014567 FeS/SAM binding site; other site 710685014568 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710685014569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710685014570 Walker A/P-loop; other site 710685014571 ATP binding site [chemical binding]; other site 710685014572 Q-loop/lid; other site 710685014573 ABC transporter signature motif; other site 710685014574 Walker B; other site 710685014575 D-loop; other site 710685014576 H-loop/switch region; other site 710685014577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710685014578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710685014579 substrate binding pocket [chemical binding]; other site 710685014580 membrane-bound complex binding site; other site 710685014581 hinge residues; other site 710685014582 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710685014583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685014584 dimer interface [polypeptide binding]; other site 710685014585 conserved gate region; other site 710685014586 putative PBP binding loops; other site 710685014587 ABC-ATPase subunit interface; other site 710685014588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685014589 dimer interface [polypeptide binding]; other site 710685014590 conserved gate region; other site 710685014591 putative PBP binding loops; other site 710685014592 ABC-ATPase subunit interface; other site 710685014593 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685014594 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685014595 recombination regulator RecX; Reviewed; Region: recX; PRK00117 710685014596 recombinase A; Provisional; Region: recA; PRK09354 710685014597 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710685014598 hexamer interface [polypeptide binding]; other site 710685014599 Walker A motif; other site 710685014600 ATP binding site [chemical binding]; other site 710685014601 Walker B motif; other site 710685014602 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 710685014603 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 710685014604 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685014605 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 710685014606 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 710685014607 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 710685014608 NifU-like domain; Region: NifU; cl00484 710685014609 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685014610 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 710685014611 nickel binding site [ion binding]; other site 710685014612 HupF/HypC family; Region: HupF_HypC; pfam01455 710685014613 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 710685014614 Acylphosphatase; Region: Acylphosphatase; pfam00708 710685014615 HypF finger; Region: zf-HYPF; pfam07503 710685014616 HypF finger; Region: zf-HYPF; pfam07503 710685014617 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 710685014618 HupF/HypC family; Region: HupF_HypC; pfam01455 710685014619 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 710685014620 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 710685014621 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 710685014622 dimerization interface [polypeptide binding]; other site 710685014623 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 710685014624 ATP binding site [chemical binding]; other site 710685014625 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 710685014626 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710685014627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710685014628 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710685014629 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710685014630 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710685014631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710685014632 non-specific DNA binding site [nucleotide binding]; other site 710685014633 salt bridge; other site 710685014634 sequence-specific DNA binding site [nucleotide binding]; other site 710685014635 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 710685014636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685014637 Coenzyme A binding pocket [chemical binding]; other site 710685014638 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 710685014639 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710685014640 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 710685014641 Uncharacterized conserved protein [Function unknown]; Region: COG1359 710685014642 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685014643 classical (c) SDRs; Region: SDR_c; cd05233 710685014644 NAD(P) binding site [chemical binding]; other site 710685014645 active site 710685014646 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710685014647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685014648 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710685014649 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685014650 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 710685014651 dimer interface [polypeptide binding]; other site 710685014652 active site 710685014653 catalytic residue [active] 710685014654 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 710685014655 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710685014656 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710685014657 nucleoside/Zn binding site; other site 710685014658 dimer interface [polypeptide binding]; other site 710685014659 catalytic motif [active] 710685014660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 710685014661 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710685014662 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710685014663 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710685014664 folate binding site [chemical binding]; other site 710685014665 NADP+ binding site [chemical binding]; other site 710685014666 thymidylate synthase; Reviewed; Region: thyA; PRK01827 710685014667 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710685014668 dimerization interface [polypeptide binding]; other site 710685014669 active site 710685014670 Dienelactone hydrolase family; Region: DLH; pfam01738 710685014671 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710685014672 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685014673 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685014674 active site 710685014675 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685014676 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685014677 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710685014678 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710685014679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 710685014680 dihydrodipicolinate reductase; Provisional; Region: PRK00048 710685014681 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685014682 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 710685014683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685014684 dimerization interface [polypeptide binding]; other site 710685014685 putative DNA binding site [nucleotide binding]; other site 710685014686 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710685014687 putative Zn2+ binding site [ion binding]; other site 710685014688 AsnC family; Region: AsnC_trans_reg; pfam01037 710685014689 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710685014690 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 710685014691 hexamer interface [polypeptide binding]; other site 710685014692 ligand binding site [chemical binding]; other site 710685014693 putative active site [active] 710685014694 NAD(P) binding site [chemical binding]; other site 710685014695 hypothetical protein; Provisional; Region: PRK01842 710685014696 SEC-C motif; Region: SEC-C; pfam02810 710685014697 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710685014698 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 710685014699 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 710685014700 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 710685014701 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 710685014702 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 710685014703 RNase E interface [polypeptide binding]; other site 710685014704 trimer interface [polypeptide binding]; other site 710685014705 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 710685014706 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 710685014707 RNase E interface [polypeptide binding]; other site 710685014708 trimer interface [polypeptide binding]; other site 710685014709 active site 710685014710 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 710685014711 putative nucleic acid binding region [nucleotide binding]; other site 710685014712 G-X-X-G motif; other site 710685014713 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 710685014714 RNA binding site [nucleotide binding]; other site 710685014715 domain interface; other site 710685014716 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 710685014717 16S/18S rRNA binding site [nucleotide binding]; other site 710685014718 S13e-L30e interaction site [polypeptide binding]; other site 710685014719 25S rRNA binding site [nucleotide binding]; other site 710685014720 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 710685014721 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710685014722 active site 710685014723 Riboflavin kinase; Region: Flavokinase; pfam01687 710685014724 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 710685014725 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 710685014726 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710685014727 FeoA domain; Region: FeoA; pfam04023 710685014728 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685014729 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685014730 substrate binding pocket [chemical binding]; other site 710685014731 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 710685014732 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 710685014733 RNA binding site [nucleotide binding]; other site 710685014734 active site 710685014735 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 710685014736 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 710685014737 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 710685014738 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 710685014739 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710685014740 active site 710685014741 metal binding site [ion binding]; metal-binding site 710685014742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685014743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014744 Predicted acyl esterases [General function prediction only]; Region: COG2936 710685014745 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710685014746 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 710685014747 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 710685014748 enoyl-CoA hydratase; Provisional; Region: PRK06190 710685014749 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685014750 substrate binding site [chemical binding]; other site 710685014751 oxyanion hole (OAH) forming residues; other site 710685014752 trimer interface [polypeptide binding]; other site 710685014753 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710685014754 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 710685014755 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710685014756 DHH family; Region: DHH; pfam01368 710685014757 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 710685014758 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710685014759 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710685014760 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 710685014761 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 710685014762 G1 box; other site 710685014763 putative GEF interaction site [polypeptide binding]; other site 710685014764 GTP/Mg2+ binding site [chemical binding]; other site 710685014765 Switch I region; other site 710685014766 G2 box; other site 710685014767 G3 box; other site 710685014768 Switch II region; other site 710685014769 G4 box; other site 710685014770 G5 box; other site 710685014771 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 710685014772 Translation-initiation factor 2; Region: IF-2; pfam11987 710685014773 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 710685014774 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 710685014775 putative RNA binding cleft [nucleotide binding]; other site 710685014776 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 710685014777 NusA N-terminal domain; Region: NusA_N; pfam08529 710685014778 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 710685014779 RNA binding site [nucleotide binding]; other site 710685014780 homodimer interface [polypeptide binding]; other site 710685014781 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710685014782 G-X-X-G motif; other site 710685014783 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710685014784 G-X-X-G motif; other site 710685014785 ribosome maturation protein RimP; Reviewed; Region: PRK00092 710685014786 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 710685014787 putative oligomer interface [polypeptide binding]; other site 710685014788 putative RNA binding site [nucleotide binding]; other site 710685014789 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710685014790 dinuclear metal binding motif [ion binding]; other site 710685014791 prolyl-tRNA synthetase; Provisional; Region: PRK09194 710685014792 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 710685014793 dimer interface [polypeptide binding]; other site 710685014794 motif 1; other site 710685014795 active site 710685014796 motif 2; other site 710685014797 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 710685014798 putative deacylase active site [active] 710685014799 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710685014800 active site 710685014801 motif 3; other site 710685014802 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 710685014803 anticodon binding site; other site 710685014804 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685014805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685014806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685014807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685014808 putative substrate translocation pore; other site 710685014809 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 710685014810 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 710685014811 homodimer interface [polypeptide binding]; other site 710685014812 active site 710685014813 SAM binding site [chemical binding]; other site 710685014814 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 710685014815 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710685014816 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 710685014817 catalytic triad [active] 710685014818 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 710685014819 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 710685014820 Walker A motif; other site 710685014821 homodimer interface [polypeptide binding]; other site 710685014822 ATP binding site [chemical binding]; other site 710685014823 hydroxycobalamin binding site [chemical binding]; other site 710685014824 Walker B motif; other site 710685014825 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 710685014826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685014827 Walker A motif; other site 710685014828 ATP binding site [chemical binding]; other site 710685014829 Walker B motif; other site 710685014830 arginine finger; other site 710685014831 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 710685014832 metal ion-dependent adhesion site (MIDAS); other site 710685014833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685014834 Coenzyme A binding pocket [chemical binding]; other site 710685014835 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710685014836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685014837 mycothione reductase; Reviewed; Region: PRK07846 710685014838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710685014839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685014840 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710685014841 High-affinity nickel-transport protein; Region: NicO; cl00964 710685014842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685014843 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710685014844 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710685014845 Predicted ATPase [General function prediction only]; Region: COG3903 710685014846 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710685014847 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710685014848 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710685014849 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 710685014850 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710685014851 Phosphotransferase enzyme family; Region: APH; pfam01636 710685014852 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 710685014853 active site 710685014854 ATP binding site [chemical binding]; other site 710685014855 substrate binding site [chemical binding]; other site 710685014856 dimer interface [polypeptide binding]; other site 710685014857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685014858 dimerization interface [polypeptide binding]; other site 710685014859 putative DNA binding site [nucleotide binding]; other site 710685014860 putative Zn2+ binding site [ion binding]; other site 710685014861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685014862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685014863 DNA-binding site [nucleotide binding]; DNA binding site 710685014864 FCD domain; Region: FCD; pfam07729 710685014865 short chain dehydrogenase; Provisional; Region: PRK06057 710685014866 classical (c) SDRs; Region: SDR_c; cd05233 710685014867 NAD(P) binding site [chemical binding]; other site 710685014868 active site 710685014869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685014870 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710685014871 NAD(P) binding site [chemical binding]; other site 710685014872 catalytic residues [active] 710685014873 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 710685014874 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 710685014875 catalytic triad [active] 710685014876 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710685014877 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710685014878 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710685014879 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 710685014880 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 710685014881 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710685014882 active site 710685014883 dimer interface [polypeptide binding]; other site 710685014884 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710685014885 Ligand Binding Site [chemical binding]; other site 710685014886 Molecular Tunnel; other site 710685014887 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 710685014888 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710685014889 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685014890 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685014891 cobyric acid synthase; Provisional; Region: PRK00784 710685014892 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685014893 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685014894 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710685014895 catalytic triad [active] 710685014896 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710685014897 active site 710685014898 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710685014899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014900 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710685014901 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710685014902 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710685014903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710685014904 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 710685014905 primary dimer interface [polypeptide binding]; other site 710685014906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710685014907 Coenzyme A binding pocket [chemical binding]; other site 710685014908 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710685014909 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 710685014910 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 710685014911 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710685014912 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710685014913 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 710685014914 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 710685014915 active site 710685014916 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 710685014917 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710685014918 putative substrate binding region [chemical binding]; other site 710685014919 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710685014920 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710685014921 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710685014922 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 710685014923 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 710685014924 Fasciclin domain; Region: Fasciclin; pfam02469 710685014925 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710685014926 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 710685014927 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710685014928 catalytic residues [active] 710685014929 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 710685014930 Fasciclin domain; Region: Fasciclin; pfam02469 710685014931 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 710685014932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685014933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685014934 DNA binding residues [nucleotide binding] 710685014935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685014936 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710685014937 NAD(P) binding site [chemical binding]; other site 710685014938 active site 710685014939 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685014940 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710685014941 SelR domain; Region: SelR; pfam01641 710685014942 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685014943 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685014944 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 710685014945 DNA photolyase; Region: DNA_photolyase; pfam00875 710685014946 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685014947 classical (c) SDRs; Region: SDR_c; cd05233 710685014948 NAD(P) binding site [chemical binding]; other site 710685014949 active site 710685014950 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 710685014951 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685014952 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685014953 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685014954 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710685014955 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710685014956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685014957 active site 710685014958 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710685014959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685014960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685014961 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685014962 active site 710685014963 metal binding site [ion binding]; metal-binding site 710685014964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685014965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685014966 active site 710685014967 metal binding site [ion binding]; metal-binding site 710685014968 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710685014969 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710685014970 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 710685014971 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685014972 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685014973 Cytochrome P450; Region: p450; cl12078 710685014974 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685014975 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685014976 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685014977 active site 2 [active] 710685014978 active site 1 [active] 710685014979 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685014980 active site 2 [active] 710685014981 active site 1 [active] 710685014982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685014983 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685014984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685014985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685014986 active site 710685014987 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710685014988 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710685014989 hydrophobic ligand binding site; other site 710685014990 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685014991 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685014992 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685014993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685014994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685014995 classical (c) SDRs; Region: SDR_c; cd05233 710685014996 NAD(P) binding site [chemical binding]; other site 710685014997 active site 710685014998 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 710685014999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685015000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710685015001 NAD(P) binding site [chemical binding]; other site 710685015002 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015003 Cytochrome P450; Region: p450; cl12078 710685015004 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710685015005 Strictosidine synthase; Region: Str_synth; pfam03088 710685015006 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710685015007 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710685015008 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710685015009 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710685015010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015011 Cytochrome P450; Region: p450; cl12078 710685015012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015014 Ecdysteroid kinase; Region: EcKinase; cl17738 710685015015 Phosphotransferase enzyme family; Region: APH; pfam01636 710685015016 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685015017 putative active site [active] 710685015018 putative substrate binding site [chemical binding]; other site 710685015019 ATP binding site [chemical binding]; other site 710685015020 Phosphotransferase enzyme family; Region: APH; pfam01636 710685015021 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685015022 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685015023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015025 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710685015026 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685015027 NAD binding site [chemical binding]; other site 710685015028 catalytic residues [active] 710685015029 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685015030 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685015031 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 710685015032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710685015033 FeS/SAM binding site; other site 710685015034 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710685015035 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710685015036 ribosome recycling factor; Reviewed; Region: frr; PRK00083 710685015037 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 710685015038 hinge region; other site 710685015039 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 710685015040 putative nucleotide binding site [chemical binding]; other site 710685015041 uridine monophosphate binding site [chemical binding]; other site 710685015042 homohexameric interface [polypeptide binding]; other site 710685015043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685015044 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685015045 S-adenosylmethionine binding site [chemical binding]; other site 710685015046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710685015047 MarR family; Region: MarR; pfam01047 710685015048 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 710685015049 agmatinase; Region: agmatinase; TIGR01230 710685015050 active site 710685015051 metal binding site [ion binding]; metal-binding site 710685015052 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 710685015053 amidase; Provisional; Region: PRK07869 710685015054 Amidase; Region: Amidase; pfam01425 710685015055 elongation factor Ts; Provisional; Region: tsf; PRK09377 710685015056 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 710685015057 Elongation factor TS; Region: EF_TS; pfam00889 710685015058 Elongation factor TS; Region: EF_TS; pfam00889 710685015059 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710685015060 rRNA interaction site [nucleotide binding]; other site 710685015061 S8 interaction site; other site 710685015062 putative laminin-1 binding site; other site 710685015063 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710685015064 Peptidase family M23; Region: Peptidase_M23; pfam01551 710685015065 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710685015066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685015067 active site 710685015068 DNA binding site [nucleotide binding] 710685015069 Int/Topo IB signature motif; other site 710685015070 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 710685015071 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710685015072 putative active site [active] 710685015073 putative substrate binding site [chemical binding]; other site 710685015074 putative FMN binding site [chemical binding]; other site 710685015075 putative catalytic residues [active] 710685015076 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 710685015077 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 710685015078 FAD binding pocket [chemical binding]; other site 710685015079 FAD binding motif [chemical binding]; other site 710685015080 phosphate binding motif [ion binding]; other site 710685015081 NAD binding pocket [chemical binding]; other site 710685015082 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 710685015083 DNA protecting protein DprA; Region: dprA; TIGR00732 710685015084 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 710685015085 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 710685015086 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710685015087 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710685015088 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 710685015089 hypothetical protein; Reviewed; Region: PRK12497 710685015090 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710685015091 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710685015092 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710685015093 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710685015094 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710685015095 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 710685015096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685015097 dimer interface [polypeptide binding]; other site 710685015098 conserved gate region; other site 710685015099 ABC-ATPase subunit interface; other site 710685015100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710685015101 dimer interface [polypeptide binding]; other site 710685015102 conserved gate region; other site 710685015103 ABC-ATPase subunit interface; other site 710685015104 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710685015105 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710685015106 Walker A/P-loop; other site 710685015107 ATP binding site [chemical binding]; other site 710685015108 Q-loop/lid; other site 710685015109 ABC transporter signature motif; other site 710685015110 Walker B; other site 710685015111 D-loop; other site 710685015112 H-loop/switch region; other site 710685015113 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685015114 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015115 acyl-activating enzyme (AAE) consensus motif; other site 710685015116 AMP binding site [chemical binding]; other site 710685015117 active site 710685015118 CoA binding site [chemical binding]; other site 710685015119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710685015120 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710685015121 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685015122 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685015123 active site 710685015124 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710685015125 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685015126 active site 710685015127 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685015128 catalytic triad [active] 710685015129 dimer interface [polypeptide binding]; other site 710685015130 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 710685015131 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685015132 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 710685015133 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 710685015134 TPP-binding site [chemical binding]; other site 710685015135 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710685015136 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 710685015137 PYR/PP interface [polypeptide binding]; other site 710685015138 dimer interface [polypeptide binding]; other site 710685015139 TPP binding site [chemical binding]; other site 710685015140 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710685015141 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 710685015142 active site 710685015143 Mn binding site [ion binding]; other site 710685015144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685015145 UMP phosphatase; Provisional; Region: PRK10444 710685015146 active site 710685015147 motif I; other site 710685015148 motif II; other site 710685015149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685015150 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710685015151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015152 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 710685015153 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685015154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685015155 NAD(P) binding site [chemical binding]; other site 710685015156 active site 710685015157 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710685015158 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710685015159 active site 710685015160 iron coordination sites [ion binding]; other site 710685015161 substrate binding pocket [chemical binding]; other site 710685015162 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 710685015163 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685015164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015165 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685015166 substrate binding site [chemical binding]; other site 710685015167 trimer interface [polypeptide binding]; other site 710685015168 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685015169 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685015170 [2Fe-2S] cluster binding site [ion binding]; other site 710685015171 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710685015172 alpha subunit interface [polypeptide binding]; other site 710685015173 active site 710685015174 substrate binding site [chemical binding]; other site 710685015175 Fe binding site [ion binding]; other site 710685015176 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685015177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685015178 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710685015179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015180 Cytochrome P450; Region: p450; cl12078 710685015181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015183 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685015184 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685015185 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685015186 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710685015187 active site 710685015188 inhibitor site; inhibition site 710685015189 dimer interface [polypeptide binding]; other site 710685015190 catalytic residue [active] 710685015191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015193 active site 710685015194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015195 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685015196 classical (c) SDRs; Region: SDR_c; cd05233 710685015197 NAD(P) binding site [chemical binding]; other site 710685015198 active site 710685015199 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685015200 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685015201 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015202 Cytochrome P450; Region: p450; cl12078 710685015203 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015204 Cytochrome P450; Region: p450; cl12078 710685015205 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710685015206 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685015207 NAD binding site [chemical binding]; other site 710685015208 catalytic residues [active] 710685015209 short chain dehydrogenase; Provisional; Region: PRK06179 710685015210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685015211 NAD(P) binding site [chemical binding]; other site 710685015212 active site 710685015213 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710685015214 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 710685015215 ligand binding site [chemical binding]; other site 710685015216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710685015217 MoxR-like ATPases [General function prediction only]; Region: COG0714 710685015218 Walker A motif; other site 710685015219 ATP binding site [chemical binding]; other site 710685015220 Walker B motif; other site 710685015221 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710685015222 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710685015223 metal ion-dependent adhesion site (MIDAS); other site 710685015224 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685015225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015226 active site 710685015227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015228 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685015229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015230 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685015231 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710685015232 FMN binding site [chemical binding]; other site 710685015233 dimer interface [polypeptide binding]; other site 710685015234 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685015235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015239 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710685015240 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710685015241 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710685015242 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 710685015243 ligand binding site [chemical binding]; other site 710685015244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015245 Cytochrome P450; Region: p450; cl12078 710685015246 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685015247 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685015248 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685015249 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685015250 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 710685015251 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 710685015252 RNA/DNA hybrid binding site [nucleotide binding]; other site 710685015253 active site 710685015254 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710685015255 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710685015256 Catalytic site [active] 710685015257 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710685015258 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 710685015259 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710685015260 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 710685015261 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 710685015262 RimM N-terminal domain; Region: RimM; pfam01782 710685015263 PRC-barrel domain; Region: PRC; pfam05239 710685015264 hypothetical protein; Provisional; Region: PRK02821 710685015265 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 710685015266 G-X-X-G motif; other site 710685015267 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 710685015268 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685015269 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685015270 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685015271 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710685015272 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710685015273 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710685015274 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710685015275 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710685015276 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710685015277 active site 710685015278 signal recognition particle protein; Provisional; Region: PRK10867 710685015279 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710685015280 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710685015281 P loop; other site 710685015282 GTP binding site [chemical binding]; other site 710685015283 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 710685015284 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710685015285 PII uridylyl-transferase; Provisional; Region: PRK03381 710685015286 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710685015287 metal binding triad; other site 710685015288 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710685015289 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710685015290 Zn2+ binding site [ion binding]; other site 710685015291 Mg2+ binding site [ion binding]; other site 710685015292 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 710685015293 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710685015294 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 710685015295 Nitrogen regulatory protein P-II; Region: P-II; smart00938 710685015296 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710685015297 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 710685015298 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710685015299 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710685015300 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 710685015301 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 710685015302 homotetramer interface [polypeptide binding]; other site 710685015303 FMN binding site [chemical binding]; other site 710685015304 homodimer contacts [polypeptide binding]; other site 710685015305 putative active site [active] 710685015306 putative substrate binding site [chemical binding]; other site 710685015307 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710685015308 AAA domain; Region: AAA_23; pfam13476 710685015309 Walker A/P-loop; other site 710685015310 ATP binding site [chemical binding]; other site 710685015311 Q-loop/lid; other site 710685015312 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 710685015313 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710685015314 ABC transporter signature motif; other site 710685015315 Walker B; other site 710685015316 D-loop; other site 710685015317 H-loop/switch region; other site 710685015318 acylphosphatase; Provisional; Region: PRK14422 710685015319 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 710685015320 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710685015321 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710685015322 DNA binding site [nucleotide binding] 710685015323 catalytic residue [active] 710685015324 H2TH interface [polypeptide binding]; other site 710685015325 putative catalytic residues [active] 710685015326 turnover-facilitating residue; other site 710685015327 intercalation triad [nucleotide binding]; other site 710685015328 8OG recognition residue [nucleotide binding]; other site 710685015329 putative reading head residues; other site 710685015330 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710685015331 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710685015332 ribonuclease III; Reviewed; Region: rnc; PRK00102 710685015333 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 710685015334 dimerization interface [polypeptide binding]; other site 710685015335 active site 710685015336 metal binding site [ion binding]; metal-binding site 710685015337 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 710685015338 dsRNA binding site [nucleotide binding]; other site 710685015339 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 710685015340 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710685015341 Hemerythrin-like domain; Region: Hr-like; cd12108 710685015342 Fe binding site [ion binding]; other site 710685015343 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 710685015344 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 710685015345 active site 710685015346 (T/H)XGH motif; other site 710685015347 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 710685015348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685015349 S-adenosylmethionine binding site [chemical binding]; other site 710685015350 pyruvate carboxylase; Reviewed; Region: PRK12999 710685015351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710685015352 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685015353 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710685015354 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 710685015355 active site 710685015356 catalytic residues [active] 710685015357 metal binding site [ion binding]; metal-binding site 710685015358 homodimer binding site [polypeptide binding]; other site 710685015359 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710685015360 carboxyltransferase (CT) interaction site; other site 710685015361 biotinylation site [posttranslational modification]; other site 710685015362 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 710685015363 putative active site [active] 710685015364 redox center [active] 710685015365 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710685015366 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 710685015367 catalytic residues [active] 710685015368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685015369 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710685015370 substrate binding pocket [chemical binding]; other site 710685015371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685015372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685015373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685015374 active site 710685015375 catalytic tetrad [active] 710685015376 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710685015377 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710685015378 active site 710685015379 catalytic tetrad [active] 710685015380 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710685015381 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 710685015382 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710685015383 generic binding surface II; other site 710685015384 ssDNA binding site; other site 710685015385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710685015386 ATP binding site [chemical binding]; other site 710685015387 putative Mg++ binding site [ion binding]; other site 710685015388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710685015389 nucleotide binding region [chemical binding]; other site 710685015390 ATP-binding site [chemical binding]; other site 710685015391 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710685015392 DAK2 domain; Region: Dak2; pfam02734 710685015393 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710685015394 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 710685015395 ligand binding site [chemical binding]; other site 710685015396 active site 710685015397 UGI interface [polypeptide binding]; other site 710685015398 catalytic site [active] 710685015399 thiamine monophosphate kinase; Provisional; Region: PRK05731 710685015400 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 710685015401 ATP binding site [chemical binding]; other site 710685015402 dimerization interface [polypeptide binding]; other site 710685015403 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710685015404 AsnC family; Region: AsnC_trans_reg; pfam01037 710685015405 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 710685015406 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 710685015407 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 710685015408 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710685015409 cystathionine gamma-lyase; Validated; Region: PRK07582 710685015410 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710685015411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685015412 catalytic residue [active] 710685015413 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 710685015414 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710685015415 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710685015416 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 710685015417 polyphosphate kinase; Provisional; Region: PRK05443 710685015418 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 710685015419 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 710685015420 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 710685015421 putative domain interface [polypeptide binding]; other site 710685015422 putative active site [active] 710685015423 catalytic site [active] 710685015424 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710685015425 putative active site [active] 710685015426 catalytic site [active] 710685015427 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710685015428 active site 710685015429 Ap6A binding site [chemical binding]; other site 710685015430 nudix motif; other site 710685015431 metal binding site [ion binding]; metal-binding site 710685015432 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685015433 catalytic core [active] 710685015434 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710685015435 IHF - DNA interface [nucleotide binding]; other site 710685015436 IHF dimer interface [polypeptide binding]; other site 710685015437 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 710685015438 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 710685015439 substrate binding site [chemical binding]; other site 710685015440 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 710685015441 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 710685015442 substrate binding site [chemical binding]; other site 710685015443 ligand binding site [chemical binding]; other site 710685015444 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710685015445 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685015446 Bacterial transcriptional regulator; Region: IclR; pfam01614 710685015447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685015448 active site 710685015449 Erythromycin esterase; Region: Erythro_esteras; pfam05139 710685015450 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 710685015451 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710685015452 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685015453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015455 Ligand Binding Site [chemical binding]; other site 710685015456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015457 Ligand Binding Site [chemical binding]; other site 710685015458 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015459 Ligand Binding Site [chemical binding]; other site 710685015460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015461 Ligand Binding Site [chemical binding]; other site 710685015462 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015463 Ligand Binding Site [chemical binding]; other site 710685015464 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 710685015465 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685015466 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685015467 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015468 Ligand Binding Site [chemical binding]; other site 710685015469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015470 Ligand Binding Site [chemical binding]; other site 710685015471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015472 Ligand Binding Site [chemical binding]; other site 710685015473 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685015474 Ligand Binding Site [chemical binding]; other site 710685015475 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710685015476 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710685015477 HIGH motif; other site 710685015478 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710685015479 active site 710685015480 KMSKS motif; other site 710685015481 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 710685015482 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710685015483 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710685015484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685015485 putative substrate translocation pore; other site 710685015486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685015487 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 710685015488 tartrate dehydrogenase; Region: TTC; TIGR02089 710685015489 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 710685015490 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 710685015491 ligand binding site [chemical binding]; other site 710685015492 NAD binding site [chemical binding]; other site 710685015493 dimerization interface [polypeptide binding]; other site 710685015494 catalytic site [active] 710685015495 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 710685015496 putative L-serine binding site [chemical binding]; other site 710685015497 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710685015498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710685015499 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 710685015500 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 710685015501 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685015502 DNA binding residues [nucleotide binding] 710685015503 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 710685015504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710685015505 active site 710685015506 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710685015507 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710685015508 ketol-acid reductoisomerase; Provisional; Region: PRK05479 710685015509 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 710685015510 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 710685015511 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 710685015512 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 710685015513 putative valine binding site [chemical binding]; other site 710685015514 dimer interface [polypeptide binding]; other site 710685015515 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 710685015516 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 710685015517 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710685015518 PYR/PP interface [polypeptide binding]; other site 710685015519 dimer interface [polypeptide binding]; other site 710685015520 TPP binding site [chemical binding]; other site 710685015521 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 710685015522 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 710685015523 TPP-binding site [chemical binding]; other site 710685015524 dimer interface [polypeptide binding]; other site 710685015525 Protein of unknown function (DUF983); Region: DUF983; cl02211 710685015526 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710685015527 Predicted membrane protein [Function unknown]; Region: COG2259 710685015528 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710685015529 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 710685015530 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710685015531 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710685015532 GatB domain; Region: GatB_Yqey; smart00845 710685015533 6-phosphofructokinase; Provisional; Region: PRK03202 710685015534 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 710685015535 active site 710685015536 ADP/pyrophosphate binding site [chemical binding]; other site 710685015537 dimerization interface [polypeptide binding]; other site 710685015538 allosteric effector site; other site 710685015539 fructose-1,6-bisphosphate binding site; other site 710685015540 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710685015541 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 710685015542 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 710685015543 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 710685015544 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685015545 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 710685015546 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710685015547 nucleotide binding pocket [chemical binding]; other site 710685015548 K-X-D-G motif; other site 710685015549 catalytic site [active] 710685015550 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710685015551 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710685015552 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 710685015553 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 710685015554 Dimer interface [polypeptide binding]; other site 710685015555 BRCT sequence motif; other site 710685015556 Protein of unknown function (DUF419); Region: DUF419; pfam04237 710685015557 4-coumarate--CoA ligase; Region: PLN02246 710685015558 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 710685015559 acyl-activating enzyme (AAE) consensus motif; other site 710685015560 active site 710685015561 putative CoA binding site [chemical binding]; other site 710685015562 AMP binding site [chemical binding]; other site 710685015563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710685015564 dimerization interface [polypeptide binding]; other site 710685015565 putative DNA binding site [nucleotide binding]; other site 710685015566 putative Zn2+ binding site [ion binding]; other site 710685015567 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 710685015568 putative hydrophobic ligand binding site [chemical binding]; other site 710685015569 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 710685015570 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685015571 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710685015572 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 710685015573 Ligand Binding Site [chemical binding]; other site 710685015574 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 710685015575 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 710685015576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710685015577 catalytic residue [active] 710685015578 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685015579 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685015580 putative acyl-acceptor binding pocket; other site 710685015581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 710685015582 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710685015583 putative FMN binding site [chemical binding]; other site 710685015584 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 710685015585 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 710685015586 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 710685015587 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 710685015588 Ligand binding site [chemical binding]; other site 710685015589 Electron transfer flavoprotein domain; Region: ETF; pfam01012 710685015590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685015591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685015592 S-adenosylmethionine binding site [chemical binding]; other site 710685015593 Uncharacterized conserved protein [Function unknown]; Region: COG1543 710685015594 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 710685015595 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 710685015596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710685015597 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710685015598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685015599 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710685015600 substrate binding pocket [chemical binding]; other site 710685015601 catalytic triad [active] 710685015602 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 710685015603 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 710685015604 trimer interface [polypeptide binding]; other site 710685015605 active site 710685015606 substrate binding site [chemical binding]; other site 710685015607 CoA binding site [chemical binding]; other site 710685015608 FOG: WD40-like repeat [Function unknown]; Region: COG1520 710685015609 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 710685015610 active site 710685015611 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 710685015612 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710685015613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685015614 S-adenosylmethionine binding site [chemical binding]; other site 710685015615 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685015616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015617 substrate binding site [chemical binding]; other site 710685015618 oxyanion hole (OAH) forming residues; other site 710685015619 trimer interface [polypeptide binding]; other site 710685015620 endoglucanase; Region: PLN02171 710685015621 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 710685015622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685015623 Walker A/P-loop; other site 710685015624 ATP binding site [chemical binding]; other site 710685015625 Q-loop/lid; other site 710685015626 ABC transporter signature motif; other site 710685015627 Walker B; other site 710685015628 D-loop; other site 710685015629 H-loop/switch region; other site 710685015630 Predicted membrane protein [Function unknown]; Region: COG2364 710685015631 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710685015632 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710685015633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685015634 DNA-binding site [nucleotide binding]; DNA binding site 710685015635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710685015636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710685015637 homodimer interface [polypeptide binding]; other site 710685015638 catalytic residue [active] 710685015639 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 710685015640 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 710685015641 phosphoserine phosphatase SerB; Region: serB; TIGR00338 710685015642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710685015643 motif II; other site 710685015644 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710685015645 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710685015646 D-pathway; other site 710685015647 Putative ubiquinol binding site [chemical binding]; other site 710685015648 Low-spin heme (heme b) binding site [chemical binding]; other site 710685015649 Putative water exit pathway; other site 710685015650 Binuclear center (heme o3/CuB) [ion binding]; other site 710685015651 K-pathway; other site 710685015652 Putative proton exit pathway; other site 710685015653 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 710685015654 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710685015655 siderophore binding site; other site 710685015656 YCII-related domain; Region: YCII; cl00999 710685015657 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710685015658 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 710685015659 putative NAD(P) binding site [chemical binding]; other site 710685015660 putative substrate binding site [chemical binding]; other site 710685015661 catalytic Zn binding site [ion binding]; other site 710685015662 structural Zn binding site [ion binding]; other site 710685015663 dimer interface [polypeptide binding]; other site 710685015664 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710685015665 GAF domain; Region: GAF; pfam01590 710685015666 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710685015667 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710685015668 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710685015669 Cutinase; Region: Cutinase; pfam01083 710685015670 EcsC protein family; Region: EcsC; pfam12787 710685015671 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685015672 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685015673 active site 710685015674 ATP binding site [chemical binding]; other site 710685015675 substrate binding site [chemical binding]; other site 710685015676 activation loop (A-loop); other site 710685015677 PknH-like extracellular domain; Region: PknH_C; pfam14032 710685015678 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 710685015679 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 710685015680 dimer interface [polypeptide binding]; other site 710685015681 putative radical transfer pathway; other site 710685015682 diiron center [ion binding]; other site 710685015683 tyrosyl radical; other site 710685015684 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685015685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685015686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015688 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710685015689 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710685015690 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710685015691 dimerization interface [polypeptide binding]; other site 710685015692 substrate binding pocket [chemical binding]; other site 710685015693 Predicted transcriptional regulator [Transcription]; Region: COG2345 710685015694 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710685015695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710685015696 S-adenosylmethionine binding site [chemical binding]; other site 710685015697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710685015698 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 710685015699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710685015700 Walker A/P-loop; other site 710685015701 ATP binding site [chemical binding]; other site 710685015702 Q-loop/lid; other site 710685015703 ABC transporter signature motif; other site 710685015704 Walker B; other site 710685015705 D-loop; other site 710685015706 H-loop/switch region; other site 710685015707 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 710685015708 GIY-YIG motif/motif A; other site 710685015709 putative active site [active] 710685015710 putative metal binding site [ion binding]; other site 710685015711 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 710685015712 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 710685015713 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 710685015714 Class I ribonucleotide reductase; Region: RNR_I; cd01679 710685015715 active site 710685015716 dimer interface [polypeptide binding]; other site 710685015717 catalytic residues [active] 710685015718 effector binding site; other site 710685015719 R2 peptide binding site; other site 710685015720 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 710685015721 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710685015722 catalytic residues [active] 710685015723 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710685015724 Predicted flavoprotein [General function prediction only]; Region: COG0431 710685015725 DNA polymerase IV; Validated; Region: PRK03352 710685015726 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710685015727 active site 710685015728 DNA binding site [nucleotide binding] 710685015729 short chain dehydrogenase; Provisional; Region: PRK07832 710685015730 classical (c) SDRs; Region: SDR_c; cd05233 710685015731 NAD(P) binding site [chemical binding]; other site 710685015732 active site 710685015733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015735 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015736 Cytochrome P450; Region: p450; cl12078 710685015737 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710685015738 Phosphotransferase enzyme family; Region: APH; pfam01636 710685015739 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710685015740 putative active site [active] 710685015741 putative substrate binding site [chemical binding]; other site 710685015742 ATP binding site [chemical binding]; other site 710685015743 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710685015744 pyruvate dehydrogenase; Provisional; Region: PRK09124 710685015745 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 710685015746 PYR/PP interface [polypeptide binding]; other site 710685015747 tetramer interface [polypeptide binding]; other site 710685015748 dimer interface [polypeptide binding]; other site 710685015749 TPP binding site [chemical binding]; other site 710685015750 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710685015751 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 710685015752 TPP-binding site [chemical binding]; other site 710685015753 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710685015754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685015755 NAD(P) binding site [chemical binding]; other site 710685015756 active site 710685015757 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710685015758 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710685015759 Moco binding site; other site 710685015760 metal coordination site [ion binding]; other site 710685015761 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 710685015762 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 710685015763 active site 710685015764 DNA binding site [nucleotide binding] 710685015765 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 710685015766 DNA binding site [nucleotide binding] 710685015767 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710685015768 Predicted transcriptional regulator [Transcription]; Region: COG2345 710685015769 Helix-turn-helix domain; Region: HTH_20; pfam12840 710685015770 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 710685015771 heme-binding site [chemical binding]; other site 710685015772 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 710685015773 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 710685015774 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 710685015775 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 710685015776 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 710685015777 [4Fe-4S] binding site [ion binding]; other site 710685015778 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685015779 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685015780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685015781 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 710685015782 molybdopterin cofactor binding site; other site 710685015783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685015784 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 710685015785 putative substrate translocation pore; other site 710685015786 carbon starvation protein A; Provisional; Region: PRK15015 710685015787 Carbon starvation protein CstA; Region: CstA; pfam02554 710685015788 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 710685015789 Protein of unknown function (DUF466); Region: DUF466; pfam04328 710685015790 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710685015791 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710685015792 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 710685015793 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710685015794 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015795 Cytochrome P450; Region: p450; cl12078 710685015796 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685015797 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710685015798 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710685015799 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710685015800 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710685015801 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 710685015802 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685015803 SnoaL-like domain; Region: SnoaL_2; pfam12680 710685015804 Phosphotransferase enzyme family; Region: APH; pfam01636 710685015805 Ecdysteroid kinase; Region: EcKinase; cl17738 710685015806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685015807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015808 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 710685015809 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710685015810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685015811 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710685015812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710685015813 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 710685015814 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 710685015815 homodimer interface [polypeptide binding]; other site 710685015816 putative substrate binding pocket [chemical binding]; other site 710685015817 diiron center [ion binding]; other site 710685015818 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685015819 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685015820 [2Fe-2S] cluster binding site [ion binding]; other site 710685015821 Isochorismatase family; Region: Isochorismatase; pfam00857 710685015822 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710685015823 catalytic triad [active] 710685015824 conserved cis-peptide bond; other site 710685015825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685015826 CoenzymeA binding site [chemical binding]; other site 710685015827 subunit interaction site [polypeptide binding]; other site 710685015828 PHB binding site; other site 710685015829 acyl-CoA synthetase; Validated; Region: PRK07798 710685015830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015831 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710685015832 acyl-activating enzyme (AAE) consensus motif; other site 710685015833 acyl-activating enzyme (AAE) consensus motif; other site 710685015834 putative AMP binding site [chemical binding]; other site 710685015835 putative active site [active] 710685015836 putative CoA binding site [chemical binding]; other site 710685015837 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710685015838 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 710685015839 NAD(P) binding site [chemical binding]; other site 710685015840 catalytic residues [active] 710685015841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685015842 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685015843 NAD(P) binding site [chemical binding]; other site 710685015844 active site 710685015845 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685015846 Cytochrome P450; Region: p450; cl12078 710685015847 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685015848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015849 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685015850 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685015851 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710685015852 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685015853 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710685015854 molybdopterin cofactor binding site; other site 710685015855 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710685015856 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710685015857 molybdopterin cofactor binding site; other site 710685015858 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710685015859 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685015860 active site 710685015861 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710685015862 classical (c) SDRs; Region: SDR_c; cd05233 710685015863 NAD(P) binding site [chemical binding]; other site 710685015864 active site 710685015865 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685015866 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710685015867 classical (c) SDRs; Region: SDR_c; cd05233 710685015868 NAD(P) binding site [chemical binding]; other site 710685015869 active site 710685015870 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710685015871 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 710685015872 putative NADP binding site [chemical binding]; other site 710685015873 putative substrate binding site [chemical binding]; other site 710685015874 active site 710685015875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015877 active site 710685015878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015879 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685015880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015881 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710685015882 acyl-CoA synthetase; Validated; Region: PRK07798 710685015883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015884 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710685015885 acyl-activating enzyme (AAE) consensus motif; other site 710685015886 acyl-activating enzyme (AAE) consensus motif; other site 710685015887 putative AMP binding site [chemical binding]; other site 710685015888 putative active site [active] 710685015889 putative CoA binding site [chemical binding]; other site 710685015890 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685015891 enoyl-CoA hydratase; Provisional; Region: PRK06210 710685015892 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015893 substrate binding site [chemical binding]; other site 710685015894 oxyanion hole (OAH) forming residues; other site 710685015895 trimer interface [polypeptide binding]; other site 710685015896 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710685015897 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710685015898 active site 710685015899 inhibitor site; inhibition site 710685015900 dimer interface [polypeptide binding]; other site 710685015901 catalytic residue [active] 710685015902 enoyl-CoA hydratase; Provisional; Region: PRK08252 710685015903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015904 substrate binding site [chemical binding]; other site 710685015905 oxyanion hole (OAH) forming residues; other site 710685015906 trimer interface [polypeptide binding]; other site 710685015907 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685015908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685015909 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710685015910 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685015911 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710685015912 dimer interface [polypeptide binding]; other site 710685015913 active site 710685015914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015915 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710685015916 substrate binding site [chemical binding]; other site 710685015917 oxyanion hole (OAH) forming residues; other site 710685015918 trimer interface [polypeptide binding]; other site 710685015919 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710685015920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685015921 DNA-binding site [nucleotide binding]; DNA binding site 710685015922 FCD domain; Region: FCD; pfam07729 710685015923 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685015924 active site 2 [active] 710685015925 active site 1 [active] 710685015926 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685015927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015928 substrate binding site [chemical binding]; other site 710685015929 oxyanion hole (OAH) forming residues; other site 710685015930 trimer interface [polypeptide binding]; other site 710685015931 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685015932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015933 substrate binding site [chemical binding]; other site 710685015934 oxyanion hole (OAH) forming residues; other site 710685015935 trimer interface [polypeptide binding]; other site 710685015936 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 710685015937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685015938 substrate binding site [chemical binding]; other site 710685015939 oxyanion hole (OAH) forming residues; other site 710685015940 trimer interface [polypeptide binding]; other site 710685015941 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685015942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015943 AMP binding site [chemical binding]; other site 710685015944 active site 710685015945 acyl-activating enzyme (AAE) consensus motif; other site 710685015946 CoA binding site [chemical binding]; other site 710685015947 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685015948 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015950 acyl-activating enzyme (AAE) consensus motif; other site 710685015951 acyl-activating enzyme (AAE) consensus motif; other site 710685015952 AMP binding site [chemical binding]; other site 710685015953 active site 710685015954 CoA binding site [chemical binding]; other site 710685015955 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685015956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685015957 acyl-activating enzyme (AAE) consensus motif; other site 710685015958 AMP binding site [chemical binding]; other site 710685015959 active site 710685015960 CoA binding site [chemical binding]; other site 710685015961 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710685015962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685015963 DNA-binding site [nucleotide binding]; DNA binding site 710685015964 FCD domain; Region: FCD; pfam07729 710685015965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015967 active site 710685015968 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 710685015969 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710685015970 dimer interface [polypeptide binding]; other site 710685015971 active site 710685015972 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685015973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685015974 NAD(P) binding site [chemical binding]; other site 710685015975 active site 710685015976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685015977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685015978 active site 710685015979 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685015980 classical (c) SDRs; Region: SDR_c; cd05233 710685015981 NAD(P) binding site [chemical binding]; other site 710685015982 active site 710685015983 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710685015984 putative active site [active] 710685015985 putative catalytic site [active] 710685015986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710685015987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710685015988 metal binding site [ion binding]; metal-binding site 710685015989 active site 710685015990 I-site; other site 710685015991 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710685015992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685015993 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710685015994 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710685015995 active site 710685015996 PAS domain S-box; Region: sensory_box; TIGR00229 710685015997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710685015998 putative active site [active] 710685015999 heme pocket [chemical binding]; other site 710685016000 PAS domain S-box; Region: sensory_box; TIGR00229 710685016001 PAS domain; Region: PAS; smart00091 710685016002 PAS domain; Region: PAS_9; pfam13426 710685016003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 710685016004 putative active site [active] 710685016005 heme pocket [chemical binding]; other site 710685016006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710685016007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710685016008 metal binding site [ion binding]; metal-binding site 710685016009 active site 710685016010 I-site; other site 710685016011 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685016012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016013 active site 710685016014 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710685016015 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685016016 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685016017 active site 710685016018 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 710685016019 EamA-like transporter family; Region: EamA; pfam00892 710685016020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016024 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016025 Cytochrome P450; Region: p450; cl12078 710685016026 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016027 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710685016028 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685016029 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710685016030 iron-sulfur cluster [ion binding]; other site 710685016031 [2Fe-2S] cluster binding site [ion binding]; other site 710685016032 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685016033 hydrophobic ligand binding site; other site 710685016034 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710685016035 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710685016036 FMN binding site [chemical binding]; other site 710685016037 substrate binding site [chemical binding]; other site 710685016038 putative catalytic residue [active] 710685016039 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710685016040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710685016041 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 710685016042 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 710685016043 RNA/DNA hybrid binding site [nucleotide binding]; other site 710685016044 active site 710685016045 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 710685016046 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685016047 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685016048 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685016049 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685016050 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685016051 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685016052 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685016053 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685016054 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710685016055 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685016056 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685016057 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685016058 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685016059 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685016060 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685016061 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685016062 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710685016063 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685016064 active site 710685016065 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685016066 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685016067 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685016068 Excalibur calcium-binding domain; Region: Excalibur; smart00894 710685016069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016071 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 710685016072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710685016073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710685016074 active site 710685016075 ATP binding site [chemical binding]; other site 710685016076 substrate binding site [chemical binding]; other site 710685016077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710685016078 substrate binding site [chemical binding]; other site 710685016079 activation loop (A-loop); other site 710685016080 activation loop (A-loop); other site 710685016081 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685016082 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 710685016083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016085 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 710685016086 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685016087 CoenzymeA binding site [chemical binding]; other site 710685016088 subunit interaction site [polypeptide binding]; other site 710685016089 PHB binding site; other site 710685016090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016092 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016093 Cytochrome P450; Region: p450; cl12078 710685016094 Cytochrome P450; Region: p450; cl12078 710685016095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016097 Homeodomain-like domain; Region: HTH_23; pfam13384 710685016098 Helix-turn-helix domain; Region: HTH_17; pfam12728 710685016099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685016100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710685016101 active site 710685016102 DNA binding site [nucleotide binding] 710685016103 Int/Topo IB signature motif; other site 710685016104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685016105 putative substrate translocation pore; other site 710685016106 D-galactonate transporter; Region: 2A0114; TIGR00893 710685016107 phosphoglucomutase; Validated; Region: PRK07564 710685016108 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 710685016109 active site 710685016110 substrate binding site [chemical binding]; other site 710685016111 metal binding site [ion binding]; metal-binding site 710685016112 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710685016113 catalytic core [active] 710685016114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710685016115 Ligand Binding Site [chemical binding]; other site 710685016116 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 710685016117 CrcB-like protein; Region: CRCB; pfam02537 710685016118 acyl carrier protein; Validated; Region: PRK05883 710685016119 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 710685016120 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016121 acyl-activating enzyme (AAE) consensus motif; other site 710685016122 AMP binding site [chemical binding]; other site 710685016123 active site 710685016124 CoA binding site [chemical binding]; other site 710685016125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 710685016126 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 710685016127 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 710685016128 active site 710685016129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016131 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 710685016132 putative hydrophobic ligand binding site [chemical binding]; other site 710685016133 Patatin-like phospholipase; Region: Patatin; pfam01734 710685016134 nucleophile elbow; other site 710685016135 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685016136 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685016137 NAD binding site [chemical binding]; other site 710685016138 catalytic residues [active] 710685016139 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 710685016140 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 710685016141 active site 710685016142 dimer interface [polypeptide binding]; other site 710685016143 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710685016144 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 710685016145 active site 710685016146 trimer interface [polypeptide binding]; other site 710685016147 allosteric site; other site 710685016148 active site lid [active] 710685016149 hexamer (dimer of trimers) interface [polypeptide binding]; other site 710685016150 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 710685016151 HPr interaction site; other site 710685016152 glycerol kinase (GK) interaction site [polypeptide binding]; other site 710685016153 active site 710685016154 phosphorylation site [posttranslational modification] 710685016155 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 710685016156 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 710685016157 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 710685016158 active site turn [active] 710685016159 phosphorylation site [posttranslational modification] 710685016160 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710685016161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016162 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710685016163 acyl-activating enzyme (AAE) consensus motif; other site 710685016164 acyl-activating enzyme (AAE) consensus motif; other site 710685016165 putative AMP binding site [chemical binding]; other site 710685016166 putative active site [active] 710685016167 putative CoA binding site [chemical binding]; other site 710685016168 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710685016169 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016170 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710685016171 FMN binding site [chemical binding]; other site 710685016172 dimer interface [polypeptide binding]; other site 710685016173 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016174 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685016175 enoyl-CoA hydratase; Provisional; Region: PRK08290 710685016176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016177 substrate binding site [chemical binding]; other site 710685016178 oxyanion hole (OAH) forming residues; other site 710685016179 trimer interface [polypeptide binding]; other site 710685016180 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710685016181 CoenzymeA binding site [chemical binding]; other site 710685016182 subunit interaction site [polypeptide binding]; other site 710685016183 PHB binding site; other site 710685016184 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685016185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016187 active site 710685016188 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016189 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016190 active site 710685016191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016193 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685016194 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685016195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016196 substrate binding site [chemical binding]; other site 710685016197 oxyanion hole (OAH) forming residues; other site 710685016198 trimer interface [polypeptide binding]; other site 710685016199 glycerate dehydrogenase; Provisional; Region: PRK06487 710685016200 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 710685016201 ligand binding site [chemical binding]; other site 710685016202 NAD binding site [chemical binding]; other site 710685016203 dimerization interface [polypeptide binding]; other site 710685016204 catalytic site [active] 710685016205 active site 710685016206 iron coordination sites [ion binding]; other site 710685016207 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710685016208 substrate binding pocket [chemical binding]; other site 710685016209 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 710685016210 thiolase; Provisional; Region: PRK06158 710685016211 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685016212 active site 710685016213 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685016214 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685016215 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685016216 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685016217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016218 acyl-activating enzyme (AAE) consensus motif; other site 710685016219 AMP binding site [chemical binding]; other site 710685016220 active site 710685016221 CoA binding site [chemical binding]; other site 710685016222 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 710685016223 homodimer interface [polypeptide binding]; other site 710685016224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016225 NAD binding site [chemical binding]; other site 710685016226 active site 710685016227 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685016228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016229 substrate binding site [chemical binding]; other site 710685016230 oxyanion hole (OAH) forming residues; other site 710685016231 trimer interface [polypeptide binding]; other site 710685016232 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685016233 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710685016234 active site 2 [active] 710685016235 active site 1 [active] 710685016236 enoyl-CoA hydratase; Provisional; Region: PRK06688 710685016237 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016238 substrate binding site [chemical binding]; other site 710685016239 oxyanion hole (OAH) forming residues; other site 710685016240 trimer interface [polypeptide binding]; other site 710685016241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016242 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710685016243 active site 710685016244 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685016245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016246 substrate binding site [chemical binding]; other site 710685016247 oxyanion hole (OAH) forming residues; other site 710685016248 trimer interface [polypeptide binding]; other site 710685016249 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710685016250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710685016251 substrate binding site [chemical binding]; other site 710685016252 oxyanion hole (OAH) forming residues; other site 710685016253 trimer interface [polypeptide binding]; other site 710685016254 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710685016255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016256 acyl-activating enzyme (AAE) consensus motif; other site 710685016257 AMP binding site [chemical binding]; other site 710685016258 active site 710685016259 CoA binding site [chemical binding]; other site 710685016260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710685016262 NAD(P) binding site [chemical binding]; other site 710685016263 active site 710685016264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016265 active site 710685016266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016267 classical (c) SDRs; Region: SDR_c; cd05233 710685016268 NAD(P) binding site [chemical binding]; other site 710685016269 active site 710685016270 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016271 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685016272 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685016273 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016274 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710685016275 Protein of unknown function (DUF1749); Region: DUF1749; pfam08538 710685016276 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685016277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016278 short chain dehydrogenase; Provisional; Region: PRK12827 710685016279 NAD(P) binding site [chemical binding]; other site 710685016280 active site 710685016281 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685016282 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 710685016283 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710685016284 putative NAD(P) binding site [chemical binding]; other site 710685016285 catalytic Zn binding site [ion binding]; other site 710685016286 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685016287 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685016288 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710685016289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710685016290 active site 710685016291 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 710685016292 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710685016293 acyl-activating enzyme (AAE) consensus motif; other site 710685016294 putative AMP binding site [chemical binding]; other site 710685016295 putative active site [active] 710685016296 putative CoA binding site [chemical binding]; other site 710685016297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016299 active site 710685016300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016301 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685016302 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685016304 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016305 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016306 active site 710685016307 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685016308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016309 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685016310 SnoaL-like domain; Region: SnoaL_3; pfam13474 710685016311 Isochorismatase family; Region: Isochorismatase; pfam00857 710685016312 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710685016313 catalytic triad [active] 710685016314 conserved cis-peptide bond; other site 710685016315 Amidohydrolase; Region: Amidohydro_2; pfam04909 710685016316 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710685016317 putative active site [active] 710685016318 putative catalytic site [active] 710685016319 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685016320 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685016321 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685016322 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685016323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710685016324 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685016325 NAD binding site [chemical binding]; other site 710685016326 catalytic residues [active] 710685016327 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016328 Cytochrome P450; Region: p450; cl12078 710685016329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016331 active site 710685016332 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710685016333 active site 710685016334 catalytic site [active] 710685016335 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710685016336 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685016337 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685016338 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016339 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685016340 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710685016341 active site 710685016342 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 710685016343 putative active site [active] 710685016344 putative catalytic site [active] 710685016345 lipid-transfer protein; Provisional; Region: PRK07855 710685016346 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685016347 active site 710685016348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016350 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710685016351 metal binding site [ion binding]; metal-binding site 710685016352 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016353 Cytochrome P450; Region: p450; cl12078 710685016354 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710685016355 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710685016356 SnoaL-like domain; Region: SnoaL_4; pfam13577 710685016357 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710685016358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016359 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710685016360 acyl-activating enzyme (AAE) consensus motif; other site 710685016361 acyl-activating enzyme (AAE) consensus motif; other site 710685016362 AMP binding site [chemical binding]; other site 710685016363 active site 710685016364 CoA binding site [chemical binding]; other site 710685016365 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685016366 active site 710685016367 short chain dehydrogenase; Provisional; Region: PRK07814 710685016368 classical (c) SDRs; Region: SDR_c; cd05233 710685016369 NAD(P) binding site [chemical binding]; other site 710685016370 active site 710685016371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016372 classical (c) SDRs; Region: SDR_c; cd05233 710685016373 NAD(P) binding site [chemical binding]; other site 710685016374 active site 710685016375 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710685016376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710685016377 DNA-binding site [nucleotide binding]; DNA binding site 710685016378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016379 NAD(P) binding site [chemical binding]; other site 710685016380 short chain dehydrogenase; Provisional; Region: PRK08267 710685016381 active site 710685016382 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016383 Cytochrome P450; Region: p450; cl12078 710685016384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016385 classical (c) SDRs; Region: SDR_c; cd05233 710685016386 NAD(P) binding site [chemical binding]; other site 710685016387 active site 710685016388 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 710685016389 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710685016390 classical (c) SDRs; Region: SDR_c; cd05233 710685016391 NAD(P) binding site [chemical binding]; other site 710685016392 active site 710685016393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016395 NAD(P) binding site [chemical binding]; other site 710685016396 active site 710685016397 short chain dehydrogenase; Provisional; Region: PRK07060 710685016398 NAD(P) binding site [chemical binding]; other site 710685016399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016400 active site 710685016401 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016402 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710685016403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016404 NAD(P) binding site [chemical binding]; other site 710685016405 active site 710685016406 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016407 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710685016408 Cytochrome P450; Region: p450; cl12078 710685016409 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016410 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710685016411 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710685016412 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 710685016413 ligand binding site [chemical binding]; other site 710685016414 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710685016415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016417 classical (c) SDRs; Region: SDR_c; cd05233 710685016418 NAD(P) binding site [chemical binding]; other site 710685016419 active site 710685016420 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710685016421 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710685016422 NAD binding site [chemical binding]; other site 710685016423 catalytic residues [active] 710685016424 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710685016425 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710685016426 NAD binding site [chemical binding]; other site 710685016427 catalytic Zn binding site [ion binding]; other site 710685016428 substrate binding site [chemical binding]; other site 710685016429 structural Zn binding site [ion binding]; other site 710685016430 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710685016431 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710685016432 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685016433 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685016434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710685016435 putative acyl-acceptor binding pocket; other site 710685016436 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710685016437 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710685016438 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710685016439 short chain dehydrogenase; Provisional; Region: PRK07856 710685016440 classical (c) SDRs; Region: SDR_c; cd05233 710685016441 NAD(P) binding site [chemical binding]; other site 710685016442 active site 710685016443 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 710685016444 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710685016445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016446 classical (c) SDRs; Region: SDR_c; cd05233 710685016447 NAD(P) binding site [chemical binding]; other site 710685016448 active site 710685016449 amino acid transporter; Region: 2A0306; TIGR00909 710685016450 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710685016451 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710685016452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710685016453 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016454 classical (c) SDRs; Region: SDR_c; cd05233 710685016455 NAD(P) binding site [chemical binding]; other site 710685016456 active site 710685016457 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685016458 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710685016459 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710685016460 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710685016461 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 710685016462 active site 710685016463 diiron metal binding site [ion binding]; other site 710685016464 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710685016465 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710685016466 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685016467 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685016468 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685016469 lipid-transfer protein; Provisional; Region: PRK07855 710685016470 active site 710685016471 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 710685016472 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710685016473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016474 NAD(P) binding site [chemical binding]; other site 710685016475 active site 710685016476 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710685016477 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 710685016478 putative active site [active] 710685016479 catalytic triad [active] 710685016480 putative dimer interface [polypeptide binding]; other site 710685016481 Domain of unknown function DUF302; Region: DUF302; pfam03625 710685016482 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016483 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710685016484 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710685016485 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710685016486 active site 710685016487 iron coordination sites [ion binding]; other site 710685016488 substrate binding pocket [chemical binding]; other site 710685016489 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685016490 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685016491 [2Fe-2S] cluster binding site [ion binding]; other site 710685016492 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710685016493 alpha subunit interface [polypeptide binding]; other site 710685016494 active site 710685016495 substrate binding site [chemical binding]; other site 710685016496 Fe binding site [ion binding]; other site 710685016497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710685016498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710685016499 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 710685016500 putative effector binding pocket; other site 710685016501 dimerization interface [polypeptide binding]; other site 710685016502 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710685016503 Domain of unknown function (DUF385); Region: DUF385; cl04387 710685016504 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 710685016505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710685016506 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 710685016507 putative dimer interface [polypeptide binding]; other site 710685016508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710685016509 ligand binding site [chemical binding]; other site 710685016510 Zn binding site [ion binding]; other site 710685016511 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710685016512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710685016513 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710685016514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710685016515 DNA binding residues [nucleotide binding] 710685016516 MMPL family; Region: MMPL; pfam03176 710685016517 MMPL family; Region: MMPL; pfam03176 710685016518 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 710685016519 phosphopeptide binding site; other site 710685016520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685016521 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710685016522 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710685016523 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710685016524 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685016525 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685016526 anti sigma factor interaction site; other site 710685016527 regulatory phosphorylation site [posttranslational modification]; other site 710685016528 PAS domain; Region: PAS_9; pfam13426 710685016529 GAF domain; Region: GAF_3; pfam13492 710685016530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710685016531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710685016532 dimer interface [polypeptide binding]; other site 710685016533 phosphorylation site [posttranslational modification] 710685016534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710685016535 ATP binding site [chemical binding]; other site 710685016536 Mg2+ binding site [ion binding]; other site 710685016537 G-X-G motif; other site 710685016538 Response regulator receiver domain; Region: Response_reg; pfam00072 710685016539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710685016540 active site 710685016541 phosphorylation site [posttranslational modification] 710685016542 intermolecular recognition site; other site 710685016543 dimerization interface [polypeptide binding]; other site 710685016544 PAS domain S-box; Region: sensory_box; TIGR00229 710685016545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710685016546 putative active site [active] 710685016547 heme pocket [chemical binding]; other site 710685016548 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710685016549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710685016550 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710685016551 ATP binding site [chemical binding]; other site 710685016552 Mg2+ binding site [ion binding]; other site 710685016553 G-X-G motif; other site 710685016554 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710685016555 anti sigma factor interaction site; other site 710685016556 regulatory phosphorylation site [posttranslational modification]; other site 710685016557 PAS fold; Region: PAS_3; pfam08447 710685016558 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710685016559 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710685016560 PhoU domain; Region: PhoU; pfam01895 710685016561 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 710685016562 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710685016563 DUF35 OB-fold domain; Region: DUF35; pfam01796 710685016564 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 710685016565 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710685016566 active site 710685016567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016568 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710685016569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016570 active site 710685016571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710685016572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710685016573 active site 710685016574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710685016577 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 710685016578 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016579 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710685016580 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710685016581 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 710685016582 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710685016583 DNA binding residues [nucleotide binding] 710685016584 putative dimer interface [polypeptide binding]; other site 710685016585 PAS fold; Region: PAS_3; pfam08447 710685016586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710685016587 putative active site [active] 710685016588 heme pocket [chemical binding]; other site 710685016589 ANTAR domain; Region: ANTAR; pfam03861 710685016590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710685016591 classical (c) SDRs; Region: SDR_c; cd05233 710685016592 NAD(P) binding site [chemical binding]; other site 710685016593 active site 710685016594 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 710685016595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710685016596 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710685016597 putative acyl-acceptor binding pocket; other site 710685016598 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710685016599 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710685016600 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685016601 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685016602 phosphopeptide binding site; other site 710685016603 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710685016604 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710685016605 phosphopeptide binding site; other site 710685016606 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710685016607 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710685016608 Walker A/P-loop; other site 710685016609 ATP binding site [chemical binding]; other site 710685016610 Q-loop/lid; other site 710685016611 ABC transporter signature motif; other site 710685016612 Walker B; other site 710685016613 D-loop; other site 710685016614 H-loop/switch region; other site 710685016615 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 710685016616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710685016617 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 710685016618 NAD(P) binding site [chemical binding]; other site 710685016619 active site 710685016620 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710685016621 active site 710685016622 metal binding site [ion binding]; metal-binding site 710685016623 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710685016624 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710685016625 active site 710685016626 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710685016627 catalytic triad [active] 710685016628 dimer interface [polypeptide binding]; other site 710685016629 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710685016630 classical (c) SDRs; Region: SDR_c; cd05233 710685016631 NAD(P) binding site [chemical binding]; other site 710685016632 active site 710685016633 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685016634 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710685016635 active site 710685016636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710685016637 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710685016638 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710685016639 [2Fe-2S] cluster binding site [ion binding]; other site 710685016640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710685016641 hydrophobic ligand binding site; other site 710685016642 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710685016643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016644 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710685016645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710685016646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710685016647 putative substrate translocation pore; other site 710685016648 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710685016649 nucleoside/Zn binding site; other site 710685016650 dimer interface [polypeptide binding]; other site 710685016651 catalytic motif [active] 710685016652 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710685016653 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710685016654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710685016655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710685016656 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924