-- dump date 20140619_152919 -- class Genbank::misc_feature -- table misc_feature_note -- id note 561304000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 561304000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304000003 Walker A motif; other site 561304000004 ATP binding site [chemical binding]; other site 561304000005 Walker B motif; other site 561304000006 arginine finger; other site 561304000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 561304000008 DnaA box-binding interface [nucleotide binding]; other site 561304000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 561304000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 561304000011 putative DNA binding surface [nucleotide binding]; other site 561304000012 dimer interface [polypeptide binding]; other site 561304000013 beta-clamp/clamp loader binding surface; other site 561304000014 beta-clamp/translesion DNA polymerase binding surface; other site 561304000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 561304000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 561304000017 Walker A/P-loop; other site 561304000018 ATP binding site [chemical binding]; other site 561304000019 Q-loop/lid; other site 561304000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304000021 ABC transporter signature motif; other site 561304000022 Walker B; other site 561304000023 D-loop; other site 561304000024 H-loop/switch region; other site 561304000025 hypothetical protein; Provisional; Region: PRK03195 561304000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 561304000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304000028 Mg2+ binding site [ion binding]; other site 561304000029 G-X-G motif; other site 561304000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 561304000031 anchoring element; other site 561304000032 dimer interface [polypeptide binding]; other site 561304000033 ATP binding site [chemical binding]; other site 561304000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 561304000035 active site 561304000036 putative metal-binding site [ion binding]; other site 561304000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 561304000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 561304000039 CAP-like domain; other site 561304000040 active site 561304000041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 561304000042 protein-splicing catalytic site; other site 561304000043 thioester formation/cholesterol transfer; other site 561304000044 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 561304000045 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 561304000046 DNA gyrase subunit A; Validated; Region: PRK05560 561304000047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 561304000048 primary dimer interface [polypeptide binding]; other site 561304000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561304000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 561304000057 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 561304000058 active site 561304000059 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 561304000060 putative septation inhibitor protein; Reviewed; Region: PRK00159 561304000061 possible cell division protein 561304000062 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 561304000063 Glutamine amidotransferase class-I; Region: GATase; pfam00117 561304000064 glutamine binding [chemical binding]; other site 561304000065 catalytic triad [active] 561304000066 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 561304000067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 561304000068 active site 561304000069 ATP binding site [chemical binding]; other site 561304000070 substrate binding site [chemical binding]; other site 561304000071 activation loop (A-loop); other site 561304000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 561304000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561304000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561304000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561304000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561304000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 561304000078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 561304000079 active site 561304000080 ATP binding site [chemical binding]; other site 561304000081 substrate binding site [chemical binding]; other site 561304000082 activation loop (A-loop); other site 561304000083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 561304000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561304000085 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 561304000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 561304000087 active site 561304000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 561304000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 561304000090 phosphopeptide binding site; other site 561304000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 561304000092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 561304000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 561304000094 phosphopeptide binding site; other site 561304000095 PPE-family protein 561304000096 probable membrane protein 561304000097 hypothetical protein; Validated; Region: PRK00228 561304000098 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 561304000099 Sodium Bile acid symporter family; Region: SBF; cl17470 561304000100 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 561304000101 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 561304000102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304000103 active site 561304000104 HIGH motif; other site 561304000105 nucleotide binding site [chemical binding]; other site 561304000106 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 561304000107 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304000108 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304000109 active site 561304000110 KMSKS motif; other site 561304000111 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 561304000112 tRNA binding surface [nucleotide binding]; other site 561304000116 probable membrane protein 561304000117 protease 561304000121 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 561304000122 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 561304000123 active site 561304000124 catalytic residues [active] 561304000125 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 561304000127 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 561304000130 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 561304000131 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 561304000132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 561304000133 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 561304000134 PPE family; Region: PPE; pfam00823 561304000135 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304000136 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 561304000137 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304000138 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304000139 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 561304000140 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304000141 Protein of unknown function (DUF690); Region: DUF690; pfam05108 561304000142 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 561304000143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304000144 Walker A motif; other site 561304000145 ATP binding site [chemical binding]; other site 561304000146 Walker B motif; other site 561304000147 arginine finger; other site 561304000148 EspG family; Region: ESX-1_EspG; pfam14011 561304000153 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 561304000154 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 561304000155 active site 561304000156 dimer interface [polypeptide binding]; other site 561304000157 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 561304000158 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 561304000159 active site 561304000160 FMN binding site [chemical binding]; other site 561304000161 substrate binding site [chemical binding]; other site 561304000162 3Fe-4S cluster binding site [ion binding]; other site 561304000163 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 561304000164 domain interface; other site 561304000165 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 561304000166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 561304000168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304000169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304000170 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 561304000171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561304000172 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 561304000173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 561304000174 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 561304000175 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 561304000176 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 561304000177 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 561304000178 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 561304000179 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 561304000180 active site 561304000181 catalytic site [active] 561304000182 bacterioferritin 561304000185 prephenate dehydratase; Provisional; Region: PRK11898 561304000186 Prephenate dehydratase; Region: PDT; pfam00800 561304000187 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 561304000188 putative L-Phe binding site [chemical binding]; other site 561304000189 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304000190 catalytic core [active] 561304000192 Septum formation; Region: Septum_form; pfam13845 561304000193 Septum formation; Region: Septum_form; pfam13845 561304000194 seryl-tRNA synthetase; Provisional; Region: PRK05431 561304000195 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 561304000196 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 561304000197 dimer interface [polypeptide binding]; other site 561304000198 active site 561304000199 motif 1; other site 561304000200 motif 2; other site 561304000201 motif 3; other site 561304000205 probable aminoglycoside 3'-phosphotransferase 561304000206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 561304000207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 561304000208 putative acyl-acceptor binding pocket; other site 561304000209 probable acyltransferase 561304000210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561304000211 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 561304000212 active site 561304000213 motif I; other site 561304000214 motif II; other site 561304000215 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 561304000216 hypothetical protein 561304000217 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 561304000218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 561304000219 UDP-galactopyranose mutase; Region: GLF; pfam03275 561304000220 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 561304000221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561304000222 active site 561304000223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 561304000224 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 561304000225 active site 561304000226 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 561304000227 UbiA prenyltransferase family; Region: UbiA; pfam01040 561304000228 Predicted esterase [General function prediction only]; Region: COG0627 561304000229 S-formylglutathione hydrolase; Region: PLN02442 561304000230 Putative esterase; Region: Esterase; pfam00756 561304000231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 561304000232 Cutinase; Region: Cutinase; pfam01083 561304000233 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 561304000234 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304000235 acyl-activating enzyme (AAE) consensus motif; other site 561304000236 active site 561304000237 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304000238 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304000239 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 561304000240 active site 561304000241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 561304000242 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 561304000243 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304000244 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 561304000245 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 561304000246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 561304000247 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 561304000248 acyl-CoA dehydrogenase 561304000249 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 561304000250 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 561304000251 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 561304000252 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 561304000253 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 561304000254 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 561304000255 classical (c) SDRs; Region: SDR_c; cd05233 561304000256 NAD(P) binding site [chemical binding]; other site 561304000257 active site 561304000258 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 561304000259 FAD binding domain; Region: FAD_binding_4; pfam01565 561304000260 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 561304000261 Predicted membrane protein [Function unknown]; Region: COG2246 561304000262 GtrA-like protein; Region: GtrA; pfam04138 561304000264 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 561304000265 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 561304000266 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 561304000267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 561304000268 active site 561304000269 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 561304000270 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 561304000271 Walker A/P-loop; other site 561304000272 ATP binding site [chemical binding]; other site 561304000273 Q-loop/lid; other site 561304000274 ABC transporter signature motif; other site 561304000275 Walker B; other site 561304000276 D-loop; other site 561304000277 H-loop/switch region; other site 561304000278 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 561304000279 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 561304000280 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 561304000281 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304000282 catalytic residue [active] 561304000283 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 561304000284 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 561304000285 NAD(P) binding site [chemical binding]; other site 561304000286 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 561304000287 Beta-lactamase; Region: Beta-lactamase; pfam00144 561304000288 enoyl-CoA hydratase; Provisional; Region: PRK06142 561304000289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304000290 substrate binding site [chemical binding]; other site 561304000291 oxyanion hole (OAH) forming residues; other site 561304000292 trimer interface [polypeptide binding]; other site 561304000293 GXWXG protein; Region: GXWXG; pfam14231 561304000294 histidinol-phosphate aminotransferase 561304000296 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 561304000297 putative hydrophobic ligand binding site [chemical binding]; other site 561304000298 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 561304000299 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 561304000300 homodimer interface [polypeptide binding]; other site 561304000301 active site 561304000302 TDP-binding site; other site 561304000303 acceptor substrate-binding pocket; other site 561304000304 Methyltransferase domain; Region: Methyltransf_24; pfam13578 561304000305 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 561304000306 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 561304000307 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 561304000308 homodimer interface [polypeptide binding]; other site 561304000309 active site 561304000310 TDP-binding site; other site 561304000311 Uncharacterized conserved protein [Function unknown]; Region: COG3268 561304000312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304000313 S-adenosylmethionine binding site [chemical binding]; other site 561304000314 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 561304000315 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 561304000316 acyl-CoA synthetase; Validated; Region: PRK05850 561304000317 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304000318 acyl-activating enzyme (AAE) consensus motif; other site 561304000319 active site 561304000320 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 561304000321 acyl-CoA synthetase; Validated; Region: PRK06060 561304000322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304000323 acyl-activating enzyme (AAE) consensus motif; other site 561304000324 AMP binding site [chemical binding]; other site 561304000325 active site 561304000326 CoA binding site [chemical binding]; other site 561304000327 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304000328 Erythronolide synthase docking; Region: Docking; pfam08990 561304000329 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304000330 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304000331 active site 561304000332 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 561304000333 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304000334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304000335 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 561304000336 Enoylreductase; Region: PKS_ER; smart00829 561304000337 NAD(P) binding site [chemical binding]; other site 561304000338 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 561304000339 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 561304000340 putative NADP binding site [chemical binding]; other site 561304000341 active site 561304000342 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304000343 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 561304000344 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 561304000345 acyl-CoA synthetase; Validated; Region: PRK05850 561304000346 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304000347 acyl-activating enzyme (AAE) consensus motif; other site 561304000348 active site 561304000349 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304000350 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304000351 active site 561304000352 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 561304000353 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304000354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304000355 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 561304000356 Enoylreductase; Region: PKS_ER; smart00829 561304000357 NAD(P) binding site [chemical binding]; other site 561304000358 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 561304000359 KR domain; Region: KR; pfam08659 561304000360 putative NADP binding site [chemical binding]; other site 561304000361 active site 561304000362 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304000364 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 561304000370 possible formamidopyrimidine-DNA glycosylase 561304000371 ketoacyl reductase 561304000372 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 561304000373 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 561304000374 active site 561304000375 dimer interface [polypeptide binding]; other site 561304000376 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 561304000377 dimer interface [polypeptide binding]; other site 561304000378 active site 561304000379 hypothetical protein; Provisional; Region: PRK07857 561304000380 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 561304000381 Part of AAA domain; Region: AAA_19; pfam13245 561304000382 Family description; Region: UvrD_C_2; pfam13538 561304000383 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 561304000384 Peptidase family M23; Region: Peptidase_M23; pfam01551 561304000385 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 561304000386 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 561304000387 CoA-ligase; Region: Ligase_CoA; pfam00549 561304000388 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 561304000389 CoA binding domain; Region: CoA_binding; smart00881 561304000390 CoA-ligase; Region: Ligase_CoA; pfam00549 561304000391 similar to alkanal monooxygenase beta chains 561304000392 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 561304000393 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 561304000394 active site 561304000395 cosubstrate binding site; other site 561304000396 substrate binding site [chemical binding]; other site 561304000397 catalytic site [active] 561304000398 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 561304000399 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 561304000400 purine monophosphate binding site [chemical binding]; other site 561304000401 dimer interface [polypeptide binding]; other site 561304000402 putative catalytic residues [active] 561304000403 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 561304000404 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 561304000406 acyl-CoA dehydrogenase 561304000407 acetyl/propionyl-CoA carboxylase, [beta] subunit 561304000408 acetyl/propionyl-CoA carboxylase, [alpha] subunit 561304000409 acyl-CoA dehydrogenase 561304000410 enoyl-CoA hydratase/isomerase superfamily 561304000411 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 561304000415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561304000416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561304000417 active site 561304000418 phosphorylation site [posttranslational modification] 561304000419 intermolecular recognition site; other site 561304000420 dimerization interface [polypeptide binding]; other site 561304000421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561304000422 DNA binding site [nucleotide binding] 561304000423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561304000424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561304000425 dimerization interface [polypeptide binding]; other site 561304000426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561304000427 dimer interface [polypeptide binding]; other site 561304000428 phosphorylation site [posttranslational modification] 561304000429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304000430 ATP binding site [chemical binding]; other site 561304000431 Mg2+ binding site [ion binding]; other site 561304000432 G-X-G motif; other site 561304000433 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 561304000434 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 561304000435 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 561304000436 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 561304000437 MPT binding site; other site 561304000438 trimer interface [polypeptide binding]; other site 561304000439 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 561304000440 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 561304000442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 561304000443 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 561304000444 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 561304000445 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 561304000446 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 561304000447 active site 561304000448 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 561304000449 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 561304000450 dimer interface [polypeptide binding]; other site 561304000451 putative functional site; other site 561304000452 putative MPT binding site; other site 561304000453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 561304000454 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 561304000456 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 561304000457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 561304000458 ligand binding site [chemical binding]; other site 561304000459 flexible hinge region; other site 561304000460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561304000461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561304000462 Coenzyme A binding pocket [chemical binding]; other site 561304000464 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 561304000465 arginine deiminase 561304000466 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 561304000467 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 561304000468 Predicted methyltransferases [General function prediction only]; Region: COG0313 561304000469 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 561304000470 putative SAM binding site [chemical binding]; other site 561304000471 putative homodimer interface [polypeptide binding]; other site 561304000472 PE_PGRS-family protein 561304000474 PE-family protein 561304000475 ATP-dependent DNA/RNA helicase 561304000476 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 561304000477 DNA-binding site [nucleotide binding]; DNA binding site 561304000478 RNA-binding motif; other site 561304000479 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 561304000480 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 561304000481 active site 561304000482 interdomain interaction site; other site 561304000483 putative metal-binding site [ion binding]; other site 561304000484 nucleotide binding site [chemical binding]; other site 561304000485 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 561304000486 domain I; other site 561304000487 phosphate binding site [ion binding]; other site 561304000488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 561304000489 domain II; other site 561304000490 domain III; other site 561304000491 nucleotide binding site [chemical binding]; other site 561304000492 DNA binding groove [nucleotide binding] 561304000493 catalytic site [active] 561304000494 domain IV; other site 561304000495 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 561304000496 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 561304000497 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 561304000498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561304000499 dimerization interface [polypeptide binding]; other site 561304000500 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 561304000501 cyclase homology domain; Region: CHD; cd07302 561304000502 nucleotidyl binding site; other site 561304000503 metal binding site [ion binding]; metal-binding site 561304000504 dimer interface [polypeptide binding]; other site 561304000505 DNA polymerase III subunit delta'; Validated; Region: PRK07940 561304000506 DNA polymerase III subunit delta'; Validated; Region: PRK08485 561304000507 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 561304000508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304000509 NAD(P) binding site [chemical binding]; other site 561304000510 active site 561304000511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 561304000512 unknown membrane protein 561304000513 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 561304000514 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 561304000515 Ligand binding site; other site 561304000516 Putative Catalytic site; other site 561304000517 DXD motif; other site 561304000518 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 561304000520 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 561304000521 dimer interface [polypeptide binding]; other site 561304000522 substrate binding site [chemical binding]; other site 561304000523 metal binding sites [ion binding]; metal-binding site 561304000524 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 561304000525 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 561304000527 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 561304000528 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 561304000529 Ligand Binding Site [chemical binding]; other site 561304000530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561304000531 active site 561304000532 lipoprotein 561304000534 alcohol dehydrogenase, zinc-type 561304000535 similar bacterial luciferase alpha chains 561304000536 hydrolase 561304000537 FtsH Extracellular; Region: FtsH_ext; pfam06480 561304000538 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 561304000539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304000540 Walker A motif; other site 561304000541 ATP binding site [chemical binding]; other site 561304000542 Walker B motif; other site 561304000543 arginine finger; other site 561304000544 Peptidase family M41; Region: Peptidase_M41; pfam01434 561304000545 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 561304000546 homodecamer interface [polypeptide binding]; other site 561304000547 GTP cyclohydrolase I; Provisional; Region: PLN03044 561304000548 active site 561304000549 putative catalytic site residues [active] 561304000550 zinc binding site [ion binding]; other site 561304000551 GTP-CH-I/GFRP interaction surface; other site 561304000552 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 561304000553 dihydropteroate synthase; Region: DHPS; TIGR01496 561304000554 substrate binding pocket [chemical binding]; other site 561304000555 dimer interface [polypeptide binding]; other site 561304000556 inhibitor binding site; inhibition site 561304000557 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 561304000558 homooctamer interface [polypeptide binding]; other site 561304000559 active site 561304000560 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 561304000561 catalytic center binding site [active] 561304000562 ATP binding site [chemical binding]; other site 561304000563 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 561304000564 Rossmann-like domain; Region: Rossmann-like; pfam10727 561304000565 Uncharacterized conserved protein [Function unknown]; Region: COG5495 561304000566 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 561304000567 Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414 561304000568 pantoate--beta-alanine ligase; Region: panC; TIGR00018 561304000569 active site 561304000570 nucleotide binding site [chemical binding]; other site 561304000571 HIGH motif; other site 561304000572 KMSKS motif; other site 561304000573 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 561304000574 tetramerization interface [polypeptide binding]; other site 561304000575 active site 561304000576 pantothenate kinase; Reviewed; Region: PRK13318 561304000577 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 561304000578 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 561304000579 dimer interface [polypeptide binding]; other site 561304000580 putative anticodon binding site; other site 561304000581 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 561304000582 motif 1; other site 561304000583 dimer interface [polypeptide binding]; other site 561304000584 active site 561304000585 motif 2; other site 561304000586 motif 3; other site 561304000587 Lsr2; Region: Lsr2; pfam11774 561304000588 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 561304000589 Clp amino terminal domain; Region: Clp_N; pfam02861 561304000590 Clp amino terminal domain; Region: Clp_N; pfam02861 561304000591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304000592 Walker A motif; other site 561304000593 ATP binding site [chemical binding]; other site 561304000594 Walker B motif; other site 561304000595 arginine finger; other site 561304000596 UvrB/uvrC motif; Region: UVR; pfam02151 561304000597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304000598 Walker A motif; other site 561304000599 ATP binding site [chemical binding]; other site 561304000600 Walker B motif; other site 561304000601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 561304000602 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 561304000603 chorismate binding enzyme; Region: Chorismate_bind; cl10555 561304000605 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 561304000606 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 561304000607 active site 561304000608 HIGH motif; other site 561304000609 KMSKS motif; other site 561304000610 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 561304000611 tRNA binding surface [nucleotide binding]; other site 561304000612 anticodon binding site; other site 561304000613 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 561304000614 active site 561304000615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 561304000616 Domain of unknown function (DUF348); Region: DUF348; pfam03990 561304000617 Domain of unknown function (DUF348); Region: DUF348; pfam03990 561304000618 Domain of unknown function (DUF348); Region: DUF348; pfam03990 561304000619 G5 domain; Region: G5; pfam07501 561304000620 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 561304000621 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 561304000622 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 561304000623 S-adenosylmethionine binding site [chemical binding]; other site 561304000624 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 561304000625 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 561304000626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 561304000627 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304000628 acyl-activating enzyme (AAE) consensus motif; other site 561304000629 active site 561304000630 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 561304000631 putative active site [active] 561304000632 catalytic residue [active] 561304000633 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 561304000634 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 561304000635 5S rRNA interface [nucleotide binding]; other site 561304000636 CTC domain interface [polypeptide binding]; other site 561304000637 L16 interface [polypeptide binding]; other site 561304000638 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 561304000639 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 561304000640 ArsC family; Region: ArsC; pfam03960 561304000641 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 561304000642 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 561304000643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561304000644 active site 561304000645 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 561304000646 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 561304000647 Substrate binding site; other site 561304000648 Mg++ binding site; other site 561304000649 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 561304000650 active site 561304000651 substrate binding site [chemical binding]; other site 561304000652 CoA binding site [chemical binding]; other site 561304000653 transcriptional regulator (TetR/AcrR family) 561304000654 diaminopimelate decarboxylase 561304000655 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 561304000656 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 561304000657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304000658 ATP binding site [chemical binding]; other site 561304000659 putative Mg++ binding site [ion binding]; other site 561304000660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304000661 nucleotide binding region [chemical binding]; other site 561304000662 ATP-binding site [chemical binding]; other site 561304000663 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 561304000665 lipoprotein 561304000666 enolase; Provisional; Region: eno; PRK00077 561304000667 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 561304000668 dimer interface [polypeptide binding]; other site 561304000669 metal binding site [ion binding]; metal-binding site 561304000670 substrate binding pocket [chemical binding]; other site 561304000671 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 561304000672 Septum formation initiator; Region: DivIC; pfam04977 561304000673 Uncharacterized conserved protein [Function unknown]; Region: COG1507 561304000674 exopolyphosphatase; Region: exo_poly_only; TIGR03706 561304000675 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 561304000676 conserved large membrane protein 561304000677 sensor histidine kinase 561304000678 two-component response regulator 561304000680 PE-family protein 561304000683 acetate kinase 561304000684 phosphate acetyltransferase 561304000685 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 561304000686 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 561304000687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561304000688 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 561304000689 oxidoreductase 561304000690 acyl-CoA dehydrogenase 561304000692 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 561304000693 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 561304000694 homodimer interface [polypeptide binding]; other site 561304000695 substrate-cofactor binding pocket; other site 561304000696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304000697 catalytic residue [active] 561304000698 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 561304000699 active site residue [active] 561304000700 PPE-family protein 561304000702 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 561304000703 CoenzymeA binding site [chemical binding]; other site 561304000704 subunit interaction site [polypeptide binding]; other site 561304000705 PHB binding site; other site 561304000706 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 561304000707 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 561304000708 GDP-binding site [chemical binding]; other site 561304000709 ACT binding site; other site 561304000710 IMP binding site; other site 561304000712 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 561304000713 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 561304000714 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 561304000715 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 561304000716 active site 561304000717 intersubunit interface [polypeptide binding]; other site 561304000718 zinc binding site [ion binding]; other site 561304000719 Na+ binding site [ion binding]; other site 561304000720 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 561304000721 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 561304000725 MarR family; Region: MarR_2; cl17246 561304000726 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 561304000727 ThiC-associated domain; Region: ThiC-associated; pfam13667 561304000728 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 561304000729 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 561304000730 dimer interface [polypeptide binding]; other site 561304000731 substrate binding site [chemical binding]; other site 561304000732 ATP binding site [chemical binding]; other site 561304000734 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 561304000735 ThiS interaction site; other site 561304000736 putative active site [active] 561304000737 tetramer interface [polypeptide binding]; other site 561304000738 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 561304000739 thiS-thiF/thiG interaction site; other site 561304000740 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 561304000741 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 561304000742 thiamine phosphate binding site [chemical binding]; other site 561304000743 active site 561304000744 pyrophosphate binding site [ion binding]; other site 561304000745 MutT homologue 561304000746 membrane protein 561304000747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561304000748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561304000749 substrate binding pocket [chemical binding]; other site 561304000750 membrane-bound complex binding site; other site 561304000751 hinge residues; other site 561304000752 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 561304000753 Catalytic domain of Protein Kinases; Region: PKc; cd00180 561304000754 active site 561304000755 ATP binding site [chemical binding]; other site 561304000756 substrate binding site [chemical binding]; other site 561304000757 activation loop (A-loop); other site 561304000758 unknown, possible membrane protein 561304000759 possible transmembrane protein 561304000761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 561304000762 ATPase of AAA-family 561304000763 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 561304000764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 561304000765 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 561304000766 molybdenum cofactor biosynthesis, protein A 561304000767 probable oxidoreductase 561304000768 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 561304000769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 561304000770 substrate binding pocket [chemical binding]; other site 561304000771 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 561304000772 short chain dehydrogenase; Provisional; Region: PRK06197 561304000773 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 561304000774 putative NAD(P) binding site [chemical binding]; other site 561304000775 active site 561304000776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304000777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304000778 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 561304000779 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 561304000780 ring oligomerisation interface [polypeptide binding]; other site 561304000781 ATP/Mg binding site [chemical binding]; other site 561304000782 stacking interactions; other site 561304000783 hinge regions; other site 561304000784 probable DNA repair RadA homologue 561304000785 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 561304000786 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 561304000787 substrate binding site; other site 561304000788 dimer interface; other site 561304000789 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 561304000790 homotrimer interaction site [polypeptide binding]; other site 561304000791 zinc binding site [ion binding]; other site 561304000792 CDP-binding sites; other site 561304000793 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 561304000794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304000795 active site 561304000796 HIGH motif; other site 561304000797 nucleotide binding site [chemical binding]; other site 561304000798 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 561304000799 KMSKS motif; other site 561304000800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 561304000801 tRNA binding surface [nucleotide binding]; other site 561304000802 anticodon binding site; other site 561304000803 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 561304000804 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 561304000805 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 561304000806 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 561304000809 PPE-family protein 561304000812 probable arsenical pump 561304000814 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 561304000815 putative active site [active] 561304000816 similar to ser-thr-protein kinases 561304000817 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 561304000818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 561304000819 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 561304000820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304000821 Walker A/P-loop; other site 561304000822 ATP binding site [chemical binding]; other site 561304000823 Q-loop/lid; other site 561304000824 ABC transporter signature motif; other site 561304000825 Walker B; other site 561304000826 D-loop; other site 561304000827 H-loop/switch region; other site 561304000828 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 561304000829 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 561304000830 metal binding site [ion binding]; metal-binding site 561304000831 transcriptional regulator (LacI family) 561304000832 transcriptional regulator (TetR/AcrR family) 561304000833 acyl-CoA dehydrogenase 561304000835 electron transfer component of 561304000836 oxidoreductase 561304000837 probable hydrolase 561304000838 lipid carrier protein 561304000839 transcriptional regulator 561304000841 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 561304000842 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 561304000844 probable transferase 561304000845 enoyl-CoA hydratase/isomerase superfamily 561304000846 acyl-CoA synthase 561304000848 hypothetical protein; Validated; Region: PRK07586 561304000849 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 561304000850 PYR/PP interface [polypeptide binding]; other site 561304000851 dimer interface [polypeptide binding]; other site 561304000852 TPP binding site [chemical binding]; other site 561304000853 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 561304000854 TPP-binding site [chemical binding]; other site 561304000855 dimer interface [polypeptide binding]; other site 561304000856 acyl-CoA synthase 561304000857 acyl-CoA dehydrogenase 561304000858 acyl-CoA dehydrogenase 561304000859 ferredoxin 561304000860 dehydrogenase 561304000861 part of mce4 operon 561304000862 part of mce4 operon 561304000863 cell invasion protein 561304000864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 561304000865 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 561304000866 23S rRNA interface [nucleotide binding]; other site 561304000867 L3 interface [polypeptide binding]; other site 561304000868 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 561304000869 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 561304000870 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 561304000871 active site 561304000872 substrate binding site [chemical binding]; other site 561304000873 metal binding site [ion binding]; metal-binding site 561304000876 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 561304000877 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 561304000878 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 561304000879 glutaminase active site [active] 561304000880 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 561304000881 dimer interface [polypeptide binding]; other site 561304000882 active site 561304000883 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 561304000884 dimer interface [polypeptide binding]; other site 561304000885 active site 561304000887 Uncharacterized conserved protein [Function unknown]; Region: COG0062 561304000888 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 561304000889 putative substrate binding site [chemical binding]; other site 561304000890 putative ATP binding site [chemical binding]; other site 561304000891 glutamate decarboxylase 561304000892 alanine racemase; Reviewed; Region: alr; PRK00053 561304000893 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 561304000894 active site 561304000895 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561304000896 dimer interface [polypeptide binding]; other site 561304000897 substrate binding site [chemical binding]; other site 561304000898 catalytic residues [active] 561304000899 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 561304000900 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 561304000901 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 561304000902 Glycoprotease family; Region: Peptidase_M22; pfam00814 561304000903 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 561304000904 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561304000905 UGMP family protein; Validated; Region: PRK09604 561304000906 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 561304000907 oligomerisation interface [polypeptide binding]; other site 561304000908 mobile loop; other site 561304000909 roof hairpin; other site 561304000910 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 561304000911 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 561304000912 ring oligomerisation interface [polypeptide binding]; other site 561304000913 ATP/Mg binding site [chemical binding]; other site 561304000914 stacking interactions; other site 561304000915 hinge regions; other site 561304000916 Transcription factor WhiB; Region: Whib; pfam02467 561304000917 ECF subfamily sigma subunit 561304000919 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 561304000920 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 561304000921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 561304000922 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 561304000923 active site 561304000924 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 561304000925 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 561304000926 phosphate binding site [ion binding]; other site 561304000927 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 561304000928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 561304000929 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 561304000930 possibe dioxygenase 561304000931 transcriptional regulator 561304000932 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 561304000933 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 561304000934 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 561304000935 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 561304000936 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 561304000937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561304000938 motif II; other site 561304000939 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 561304000940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304000941 S-adenosylmethionine binding site [chemical binding]; other site 561304000942 GMP synthase; Reviewed; Region: guaA; PRK00074 561304000943 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 561304000944 AMP/PPi binding site [chemical binding]; other site 561304000945 candidate oxyanion hole; other site 561304000946 catalytic triad [active] 561304000947 potential glutamine specificity residues [chemical binding]; other site 561304000948 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 561304000949 ATP Binding subdomain [chemical binding]; other site 561304000950 Ligand Binding sites [chemical binding]; other site 561304000951 Dimerization subdomain; other site 561304000952 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 561304000953 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 561304000954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 561304000955 PAS domain; Region: PAS_9; pfam13426 561304000956 putative active site [active] 561304000957 heme pocket [chemical binding]; other site 561304000958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 561304000959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 561304000960 metal binding site [ion binding]; metal-binding site 561304000961 active site 561304000962 I-site; other site 561304000963 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561304000964 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 561304000965 TM-ABC transporter signature motif; other site 561304000966 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 561304000967 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 561304000968 putative ligand binding site [chemical binding]; other site 561304000971 phosphate transport system regulator 561304000972 cutinase 561304000973 probable inosine-uridine preferring nucleoside 561304000974 cyclopropanemycolic acid synthase 561304000975 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 561304000976 FeS assembly ATPase SufC; Region: sufC; TIGR01978 561304000977 possible IS1081 transposase 561304000978 possible IS6110 transposase 561304000979 PE family; Region: PE; pfam00934 561304000980 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304000981 PPE family; Region: PPE; pfam00823 561304000982 lipoprotein 561304000983 dehydrogenase 561304000984 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 561304000985 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 561304000986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561304000987 active site 561304000988 motif I; other site 561304000989 motif II; other site 561304000991 DNA polymerase III [alpha] chain 561304000993 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 561304000994 FMN binding site [chemical binding]; other site 561304000995 dimer interface [polypeptide binding]; other site 561304000996 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 561304001001 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 561304001002 catalytic triad [active] 561304001003 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 561304001004 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 561304001005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 561304001006 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 561304001007 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 561304001008 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 561304001009 catalytic site [active] 561304001010 putative active site [active] 561304001011 putative substrate binding site [chemical binding]; other site 561304001012 dimer interface [polypeptide binding]; other site 561304001014 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 561304001015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304001016 NAD(P) binding site [chemical binding]; other site 561304001017 active site 561304001018 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 561304001019 transcriptional regulator (TetR/AcrR family) 561304001020 acyl-CoA synthase 561304001021 3-oxo acid:CoA transferase, [alpha] subunit 561304001022 3-oxo acid:CoA transferase, [beta] subunit 561304001023 acetyl/propionyl-CoA carboxylase, [beta] subunit 561304001024 acetyl/propionyl-CoA carboxylase, [alpha] subunit 561304001025 acyl-CoA dehydrogenase (aka mmgC) 561304001026 aldehyde dehydrogenase 561304001027 citrate lyase [beta] chain 561304001028 pyruvate dehydrogenase E1 component [alpha] subunit 561304001029 pyruvate dehydrogenase E1 component [beta] subunit 561304001030 dihydrolipoamide acetyltransferase 561304001031 group II intron maturase 561304001032 REP-family protein 561304001033 enoyl-CoA hydratase/isomerase superfamily 561304001034 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 561304001035 Cytochrome P450; Region: p450; cl12078 561304001036 thioesterase II 561304001037 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 561304001038 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 561304001039 active site 561304001040 multimer interface [polypeptide binding]; other site 561304001041 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 561304001042 nudix motif; other site 561304001043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561304001044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 561304001045 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 561304001046 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 561304001047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 561304001048 putative acyl-acceptor binding pocket; other site 561304001049 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 561304001050 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 561304001051 nucleotide binding site/active site [active] 561304001052 HIT family signature motif; other site 561304001053 catalytic residue [active] 561304001054 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 561304001055 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 561304001056 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 561304001057 active site 561304001058 dimer interface [polypeptide binding]; other site 561304001059 motif 1; other site 561304001060 motif 2; other site 561304001061 motif 3; other site 561304001062 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 561304001063 anticodon binding site; other site 561304001065 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 561304001066 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 561304001067 active site 561304001068 catalytic tetrad [active] 561304001075 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 561304001076 active site 561304001077 catalytic triad [active] 561304001078 oxyanion hole [active] 561304001079 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 561304001080 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 561304001081 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 561304001082 hypothetical protein; Provisional; Region: PRK10621 561304001083 acyl-CoA synthase 561304001084 ferrous iron transport protein 561304001085 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 561304001086 predicted active site [active] 561304001087 catalytic triad [active] 561304001088 hypothetical protein; Validated; Region: PRK00110 561304001089 spermidine synthase 561304001094 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 561304001095 active site 561304001096 putative DNA-binding cleft [nucleotide binding]; other site 561304001097 dimer interface [polypeptide binding]; other site 561304001098 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 561304001099 RuvA N terminal domain; Region: RuvA_N; pfam01330 561304001100 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 561304001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304001102 Walker A motif; other site 561304001103 ATP binding site [chemical binding]; other site 561304001104 Walker B motif; other site 561304001105 arginine finger; other site 561304001106 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 561304001107 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 561304001108 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304001109 acyl-activating enzyme (AAE) consensus motif; other site 561304001110 AMP binding site [chemical binding]; other site 561304001111 active site 561304001112 CoA binding site [chemical binding]; other site 561304001113 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 561304001114 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 561304001115 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 561304001116 putative NAD(P) binding site [chemical binding]; other site 561304001117 active site 561304001118 putative substrate binding site [chemical binding]; other site 561304001119 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 561304001120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 561304001121 inhibitor-cofactor binding pocket; inhibition site 561304001122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304001123 catalytic residue [active] 561304001124 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 561304001125 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 561304001126 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 561304001127 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 561304001128 Protein export membrane protein; Region: SecD_SecF; pfam02355 561304001129 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 561304001130 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 561304001131 adenine phosphoribosyltransferases 561304001132 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 561304001133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561304001134 Zn2+ binding site [ion binding]; other site 561304001135 Mg2+ binding site [ion binding]; other site 561304001136 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 561304001137 synthetase active site [active] 561304001138 NTP binding site [chemical binding]; other site 561304001139 metal binding site [ion binding]; metal-binding site 561304001140 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 561304001141 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 561304001142 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 561304001143 active site 561304001144 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 561304001145 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 561304001146 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 561304001147 dimer interface [polypeptide binding]; other site 561304001148 motif 1; other site 561304001149 active site 561304001150 motif 2; other site 561304001151 motif 3; other site 561304001152 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 561304001153 anticodon binding site; other site 561304001154 PE_PGRS-family protein 561304001160 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 561304001161 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 561304001162 dimer interface [polypeptide binding]; other site 561304001163 anticodon binding site; other site 561304001164 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 561304001165 homodimer interface [polypeptide binding]; other site 561304001166 motif 1; other site 561304001167 active site 561304001168 motif 2; other site 561304001169 GAD domain; Region: GAD; pfam02938 561304001170 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 561304001171 active site 561304001172 motif 3; other site 561304001174 PPE-family protein 561304001175 transposase 561304001179 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 561304001180 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 561304001181 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 561304001183 recombination factor protein RarA; Reviewed; Region: PRK13342 561304001184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304001185 Walker A motif; other site 561304001186 ATP binding site [chemical binding]; other site 561304001187 Walker B motif; other site 561304001188 arginine finger; other site 561304001189 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 561304001191 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 561304001192 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 561304001193 motif 1; other site 561304001194 active site 561304001195 motif 2; other site 561304001196 motif 3; other site 561304001197 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 561304001198 DHHA1 domain; Region: DHHA1; pfam02272 561304001199 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 561304001200 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 561304001201 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 561304001202 dimerization interface [polypeptide binding]; other site 561304001203 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 561304001204 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 561304001205 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 561304001206 NAD(P) binding site [chemical binding]; other site 561304001207 shikimate binding site; other site 561304001208 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 561304001209 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 561304001210 Tetramer interface [polypeptide binding]; other site 561304001211 active site 561304001212 FMN-binding site [chemical binding]; other site 561304001213 shikimate kinase; Reviewed; Region: aroK; PRK00131 561304001214 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 561304001215 ADP binding site [chemical binding]; other site 561304001216 magnesium binding site [ion binding]; other site 561304001217 putative shikimate binding site; other site 561304001218 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 561304001219 active site 561304001220 dimer interface [polypeptide binding]; other site 561304001221 metal binding site [ion binding]; metal-binding site 561304001222 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 561304001223 Dehydroquinase class II; Region: DHquinase_II; pfam01220 561304001224 trimer interface [polypeptide binding]; other site 561304001225 active site 561304001226 dimer interface [polypeptide binding]; other site 561304001227 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 561304001228 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 561304001229 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 561304001230 active site 561304001231 elongation factor P; Validated; Region: PRK00529 561304001232 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 561304001233 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 561304001234 RNA binding site [nucleotide binding]; other site 561304001235 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 561304001236 RNA binding site [nucleotide binding]; other site 561304001237 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 561304001238 putative RNA binding site [nucleotide binding]; other site 561304001239 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 561304001240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 561304001241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304001242 catalytic residue [active] 561304001243 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 561304001244 possible oxidoreductase 561304001245 probable penicillin binding protein 561304001246 some similarity to methyltransferases 561304001248 regulatory protein pyrimidine biosynthesis 561304001249 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 561304001250 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 561304001251 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 561304001252 dihydroorotase; Validated; Region: pyrC; PRK09357 561304001253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 561304001254 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 561304001255 active site 561304001257 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 561304001258 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 561304001259 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 561304001260 catalytic site [active] 561304001261 subunit interface [polypeptide binding]; other site 561304001262 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 561304001263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561304001264 ATP-grasp domain; Region: ATP-grasp_4; cl17255 561304001265 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 561304001266 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561304001267 ATP-grasp domain; Region: ATP-grasp_4; cl17255 561304001268 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 561304001269 IMP binding site; other site 561304001270 dimer interface [polypeptide binding]; other site 561304001271 interdomain contacts; other site 561304001272 partial ornithine binding site; other site 561304001273 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 561304001274 active site 561304001275 dimer interface [polypeptide binding]; other site 561304001276 PE family; Region: PE; pfam00934 561304001277 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304001278 PPE family; Region: PPE; pfam00823 561304001279 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 561304001280 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 561304001281 catalytic site [active] 561304001282 G-X2-G-X-G-K; other site 561304001283 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 561304001284 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 561304001285 Flavoprotein; Region: Flavoprotein; pfam02441 561304001286 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 561304001287 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 561304001288 S-adenosylmethionine synthetase; Validated; Region: PRK05250 561304001289 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 561304001290 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 561304001291 probable lipase 561304001292 probable lipase 561304001293 possible membrane protein 561304001294 primosome assembly protein PriA; Provisional; Region: PRK14873 561304001295 similar to phosphatidylethanolamine N-methyltransferase 561304001296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 561304001297 MarR family; Region: MarR; pfam01047 561304001298 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 561304001299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304001300 S-adenosylmethionine binding site [chemical binding]; other site 561304001301 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 561304001302 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 561304001303 putative active site [active] 561304001304 substrate binding site [chemical binding]; other site 561304001305 putative cosubstrate binding site; other site 561304001306 catalytic site [active] 561304001307 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 561304001308 substrate binding site [chemical binding]; other site 561304001309 similar to Fmu protein 561304001310 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 561304001311 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 561304001312 substrate binding site [chemical binding]; other site 561304001313 hexamer interface [polypeptide binding]; other site 561304001314 metal binding site [ion binding]; metal-binding site 561304001315 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 561304001316 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 561304001317 catalytic motif [active] 561304001318 Zn binding site [ion binding]; other site 561304001319 RibD C-terminal domain; Region: RibD_C; pfam01872 561304001320 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 561304001321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561304001322 putative substrate translocation pore; other site 561304001323 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 561304001324 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 561304001325 Lumazine binding domain; Region: Lum_binding; pfam00677 561304001326 Lumazine binding domain; Region: Lum_binding; pfam00677 561304001327 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 561304001328 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 561304001329 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 561304001330 dimerization interface [polypeptide binding]; other site 561304001331 active site 561304001332 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 561304001333 homopentamer interface [polypeptide binding]; other site 561304001334 active site 561304001335 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 561304001336 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 561304001337 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 561304001338 GIY-YIG motif/motif A; other site 561304001339 active site 561304001340 catalytic site [active] 561304001341 putative DNA binding site [nucleotide binding]; other site 561304001342 metal binding site [ion binding]; metal-binding site 561304001343 UvrB/uvrC motif; Region: UVR; pfam02151 561304001344 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 561304001345 Helix-hairpin-helix motif; Region: HHH; pfam00633 561304001346 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 561304001347 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 561304001348 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 561304001349 phosphate binding site [ion binding]; other site 561304001350 putative substrate binding pocket [chemical binding]; other site 561304001351 dimer interface [polypeptide binding]; other site 561304001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 561304001353 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 561304001355 possible transporter 561304001356 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 561304001357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 561304001358 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 561304001359 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 561304001360 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 561304001361 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 561304001362 Phosphoglycerate kinase; Region: PGK; pfam00162 561304001363 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 561304001364 substrate binding site [chemical binding]; other site 561304001365 hinge regions; other site 561304001366 ADP binding site [chemical binding]; other site 561304001367 catalytic site [active] 561304001368 triosephosphate isomerase; Provisional; Region: PRK14567 561304001369 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 561304001370 substrate binding site [chemical binding]; other site 561304001371 dimer interface [polypeptide binding]; other site 561304001372 catalytic triad [active] 561304001373 Preprotein translocase SecG subunit; Region: SecG; cl09123 561304001374 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 561304001375 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 561304001376 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 561304001377 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 561304001378 putative active site [active] 561304001379 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 561304001380 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 561304001381 glucose-6-phosphate 1-dehydrogenase 561304001382 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 561304001383 putative active site [active] 561304001384 transaldolase; Provisional; Region: PRK03903 561304001385 catalytic residue [active] 561304001386 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 561304001387 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 561304001388 TPP-binding site [chemical binding]; other site 561304001389 dimer interface [polypeptide binding]; other site 561304001390 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 561304001391 PYR/PP interface [polypeptide binding]; other site 561304001392 dimer interface [polypeptide binding]; other site 561304001393 TPP binding site [chemical binding]; other site 561304001394 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 561304001395 UbiA prenyltransferase family; Region: UbiA; pfam01040 561304001396 Probable quinone oxidoreductase 561304001398 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 561304001399 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 561304001400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 561304001401 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 561304001402 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561304001403 Walker A/P-loop; other site 561304001404 ATP binding site [chemical binding]; other site 561304001405 Q-loop/lid; other site 561304001406 ABC transporter signature motif; other site 561304001407 Walker B; other site 561304001408 D-loop; other site 561304001409 H-loop/switch region; other site 561304001410 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 561304001411 Predicted transcriptional regulator [Transcription]; Region: COG2345 561304001412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 561304001413 putative DNA binding site [nucleotide binding]; other site 561304001414 dimerization interface [polypeptide binding]; other site 561304001415 putative Zn2+ binding site [ion binding]; other site 561304001416 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 561304001417 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 561304001418 protein-splicing catalytic site; other site 561304001419 thioester formation/cholesterol transfer; other site 561304001420 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 561304001421 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 561304001422 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 561304001423 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 561304001424 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 561304001425 FeS assembly protein SufD; Region: sufD; TIGR01981 561304001426 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 561304001427 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 561304001428 Walker A/P-loop; other site 561304001429 ATP binding site [chemical binding]; other site 561304001430 Q-loop/lid; other site 561304001431 ABC transporter signature motif; other site 561304001432 Walker B; other site 561304001433 D-loop; other site 561304001434 H-loop/switch region; other site 561304001435 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 561304001436 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 561304001437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304001438 catalytic residue [active] 561304001439 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 561304001440 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 561304001441 trimerization site [polypeptide binding]; other site 561304001442 active site 561304001443 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 561304001444 acyl-CoA dehydrogenase 561304001445 acyl-CoA dehydrogenase 561304001448 hypothetical protein; Reviewed; Region: PRK07914 561304001449 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 561304001450 Uncharacterized conserved protein [Function unknown]; Region: COG2308 561304001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 561304001452 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 561304001453 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 561304001454 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 561304001455 Transglutaminase/protease-like homologues; Region: TGc; smart00460 561304001459 GTP-binding protein LepA; Provisional; Region: PRK05433 561304001460 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 561304001461 G1 box; other site 561304001462 putative GEF interaction site [polypeptide binding]; other site 561304001463 GTP/Mg2+ binding site [chemical binding]; other site 561304001464 Switch I region; other site 561304001465 G2 box; other site 561304001466 G3 box; other site 561304001467 Switch II region; other site 561304001468 G4 box; other site 561304001469 G5 box; other site 561304001470 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 561304001471 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 561304001472 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 561304001474 possible hydroxylase 561304001475 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 561304001476 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 561304001477 sulphate transport system permease 561304001478 sulphate transport system permease 561304001479 sulphate transport ATP-binding protein 561304001481 ECF family sigma factor 561304001484 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 561304001485 HTH domain; Region: HTH_11; cl17392 561304001486 chaperone protein DnaJ; Provisional; Region: PRK14278 561304001487 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 561304001488 HSP70 interaction site [polypeptide binding]; other site 561304001489 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 561304001490 Zn binding sites [ion binding]; other site 561304001491 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 561304001492 dimer interface [polypeptide binding]; other site 561304001493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 561304001494 RNA methyltransferase, RsmE family; Region: TIGR00046 561304001495 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 561304001496 K homology RNA-binding domain; Region: KH; smart00322 561304001497 PhoH-like protein; Region: PhoH; pfam02562 561304001498 metal-binding heat shock protein; Provisional; Region: PRK00016 561304001500 GTPase Era; Reviewed; Region: era; PRK00089 561304001501 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 561304001502 G1 box; other site 561304001503 GTP/Mg2+ binding site [chemical binding]; other site 561304001504 Switch I region; other site 561304001505 G2 box; other site 561304001506 Switch II region; other site 561304001507 G3 box; other site 561304001508 G4 box; other site 561304001509 G5 box; other site 561304001510 KH domain; Region: KH_2; pfam07650 561304001511 amidase 561304001512 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 561304001513 Recombination protein O N terminal; Region: RecO_N; pfam11967 561304001514 Recombination protein O C terminal; Region: RecO_C; pfam02565 561304001515 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 561304001516 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 561304001517 catalytic residue [active] 561304001518 putative FPP diphosphate binding site; other site 561304001519 putative FPP binding hydrophobic cleft; other site 561304001520 dimer interface [polypeptide binding]; other site 561304001521 putative IPP diphosphate binding site; other site 561304001523 lipoprotein 561304001525 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 561304001526 Part of AAA domain; Region: AAA_19; pfam13245 561304001527 Family description; Region: UvrD_C_2; pfam13538 561304001528 HRDC domain; Region: HRDC; pfam00570 561304001529 Transcription factor WhiB; Region: Whib; pfam02467 561304001530 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 561304001531 ABC1 family; Region: ABC1; pfam03109 561304001532 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 561304001533 active site 561304001534 ATP binding site [chemical binding]; other site 561304001536 Uncharacterized conserved protein [Function unknown]; Region: COG5282 561304001537 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 561304001538 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 561304001539 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 561304001540 hypothetical protein; Validated; Region: PRK00068 561304001541 Uncharacterized conserved protein [Function unknown]; Region: COG1615 561304001543 probable non-heme haloperoxidase 561304001544 Probable flavin-containing monoamine oxidase 561304001547 transcriptional regulator 561304001548 REP-family protein 561304001551 transcriptional regulator, MoxR homologue 561304001552 possible membrane protein 561304001553 NADH dehydrogenase chain N 561304001554 3-hydroxyacyl-CoA dehydrogenase 561304001555 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 561304001556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 561304001557 active site 561304001558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 561304001559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 561304001560 active site 561304001561 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 561304001562 active site 561304001563 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 561304001564 Some similarity to D-lactate dehydrogenase 561304001565 ferredoxin-NADP+ reductase; Region: PLN02852 561304001566 peptide chain release factor 2; Validated; Region: prfB; PRK00578 561304001567 This domain is found in peptide chain release factors; Region: PCRF; smart00937 561304001568 RF-1 domain; Region: RF-1; pfam00472 561304001570 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 561304001571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304001572 Walker A/P-loop; other site 561304001573 ATP binding site [chemical binding]; other site 561304001574 Q-loop/lid; other site 561304001575 ABC transporter signature motif; other site 561304001576 Walker B; other site 561304001577 D-loop; other site 561304001578 H-loop/switch region; other site 561304001579 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 561304001580 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 561304001581 FtsX-like permease family; Region: FtsX; pfam02687 561304001582 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 561304001583 SmpB-tmRNA interface; other site 561304001585 probable oxidoreductase 561304001586 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 561304001587 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 561304001588 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 561304001589 homodimer interface [polypeptide binding]; other site 561304001590 NADP binding site [chemical binding]; other site 561304001591 substrate binding site [chemical binding]; other site 561304001592 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 561304001593 Protein of unknown function (DUF732); Region: DUF732; pfam05305 561304001594 probable oxidoreductase 561304001595 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 561304001596 REP-family protein 561304001598 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 561304001599 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 561304001600 cystathionine [beta]-lyase 561304001601 isocitrate dehydrogenase 561304001602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 561304001603 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 561304001604 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 561304001605 active site 561304001606 HIGH motif; other site 561304001607 dimer interface [polypeptide binding]; other site 561304001608 KMSKS motif; other site 561304001609 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 561304001610 N-acetylglucosamine-6-P-deacetylase 561304001611 glucosamine-fructose-6-phosphateaminotransferase( pseudogene) 561304001612 probable sugar transport protein 561304001613 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 561304001614 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 561304001615 probable aminotransferase 561304001616 similar to SigI, ECF family 561304001619 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 561304001620 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 561304001621 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 561304001622 L-aspartate oxidase; Provisional; Region: PRK06175 561304001623 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 561304001624 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 561304001625 putative Iron-sulfur protein interface [polypeptide binding]; other site 561304001626 putative proximal heme binding site [chemical binding]; other site 561304001627 putative SdhC-like subunit interface [polypeptide binding]; other site 561304001628 putative distal heme binding site [chemical binding]; other site 561304001629 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 561304001630 putative Iron-sulfur protein interface [polypeptide binding]; other site 561304001631 putative proximal heme binding site [chemical binding]; other site 561304001632 putative SdhD-like interface [polypeptide binding]; other site 561304001633 putative distal heme binding site [chemical binding]; other site 561304001634 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 561304001635 adenosine deaminase; Provisional; Region: PRK09358 561304001636 active site 561304001637 possible membrane protein 561304001638 possible membrane protein 561304001639 probable acid phosphatase 561304001640 uracil phophoribosyltransferase 561304001641 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 561304001642 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 561304001643 active site 561304001644 substrate binding site [chemical binding]; other site 561304001645 metal binding site [ion binding]; metal-binding site 561304001646 purine nucleoside phosphorylase; Provisional; Region: PRK08202 561304001647 probable aminohydrolase 561304001648 probable aminohydrolase 561304001650 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 561304001651 putative active site pocket [active] 561304001652 dimerization interface [polypeptide binding]; other site 561304001653 putative catalytic residue [active] 561304001654 dihydrolipoamide dehydrogenase 561304001655 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 561304001656 probable deaminase, riboflavin synthesis 561304001657 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 561304001658 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 561304001659 ATP-dependent helicase 561304001660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304001661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304001662 aldehyde dehydrogenase 561304001664 transcriptional regulator (Lrp/AsnC family) 561304001665 lysine-[epsilon] aminotransferase 561304001668 anti-sigma B factor 561304001669 ECF subfamily sigma subunit 561304001670 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 561304001671 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561304001672 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 561304001673 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 561304001674 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 561304001675 carboxyltransferase (CT) interaction site; other site 561304001676 biotinylation site [posttranslational modification]; other site 561304001678 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 561304001679 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 561304001680 active site residue [active] 561304001681 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 561304001682 active site residue [active] 561304001683 Maf-like protein; Region: Maf; pfam02545 561304001684 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 561304001685 active site 561304001686 dimer interface [polypeptide binding]; other site 561304001687 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 561304001688 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 561304001689 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 561304001690 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 561304001691 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 561304001692 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 561304001693 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 561304001694 Bacterial PH domain; Region: DUF304; pfam03703 561304001695 Predicted membrane protein [Function unknown]; Region: COG2246 561304001696 GtrA-like protein; Region: GtrA; pfam04138 561304001697 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 561304001698 ATP-grasp domain; Region: ATP-grasp; pfam02222 561304001699 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 561304001700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 561304001701 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 561304001702 active site 561304001703 PstA component of phosphate uptake 561304001704 PstC component of phosphate uptake 561304001705 PstS component of phosphate uptake 561304001706 ABC transport component of phosphate uptake 561304001707 PstS component of phosphate uptake 561304001708 serine-threonine protein kinase 561304001712 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 561304001713 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561304001714 Soluble P-type ATPase [General function prediction only]; Region: COG4087 561304001715 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 561304001717 Transcriptional regulator [Transcription]; Region: LytR; COG1316 561304001718 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 561304001719 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 561304001720 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 561304001721 NADP binding site [chemical binding]; other site 561304001722 active site 561304001723 putative substrate binding site [chemical binding]; other site 561304001724 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 561304001725 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 561304001726 Probable Catalytic site; other site 561304001727 metal-binding site 561304001728 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 561304001729 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 561304001730 active site 561304001731 Substrate binding site; other site 561304001732 Mg++ binding site; other site 561304001733 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 561304001735 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 561304001736 nudix motif; other site 561304001737 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 561304001738 Methyltransferase domain; Region: Methyltransf_26; pfam13659 561304001739 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 561304001740 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 561304001741 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 561304001742 putative FMN binding site [chemical binding]; other site 561304001743 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 561304001744 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 561304001745 dimer interface [polypeptide binding]; other site 561304001746 phosphate binding site [ion binding]; other site 561304001747 Transcription factor WhiB; Region: Whib; pfam02467 561304001748 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 561304001749 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 561304001750 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 561304001751 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 561304001752 active site 561304001753 substrate binding site [chemical binding]; other site 561304001754 metal binding site [ion binding]; metal-binding site 561304001755 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 561304001756 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 561304001757 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 561304001759 probable cationic amino acid transporter 561304001760 possible alkane-1 monooxygenase 561304001761 possible rubredoxin 561304001762 transcriptional regulator (TetR/AcrR family) 561304001763 Adenosylhomocysteinase; Provisional; Region: PTZ00075 561304001764 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 561304001765 homotetramer interface [polypeptide binding]; other site 561304001766 ligand binding site [chemical binding]; other site 561304001767 catalytic site [active] 561304001768 NAD binding site [chemical binding]; other site 561304001769 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 561304001770 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 561304001771 TMP-binding site; other site 561304001772 ATP-binding site [chemical binding]; other site 561304001773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561304001774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561304001775 active site 561304001776 phosphorylation site [posttranslational modification] 561304001777 intermolecular recognition site; other site 561304001778 dimerization interface [polypeptide binding]; other site 561304001779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561304001780 DNA binding site [nucleotide binding] 561304001781 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 561304001782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561304001783 dimerization interface [polypeptide binding]; other site 561304001784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561304001785 dimer interface [polypeptide binding]; other site 561304001786 phosphorylation site [posttranslational modification] 561304001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304001788 ATP binding site [chemical binding]; other site 561304001789 Mg2+ binding site [ion binding]; other site 561304001790 G-X-G motif; other site 561304001791 lipoprotein LpqB; Provisional; Region: PRK13616 561304001792 Sporulation and spore germination; Region: Germane; pfam10646 561304001793 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 561304001794 30S subunit binding site; other site 561304001795 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 561304001796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 561304001797 ATP binding site [chemical binding]; other site 561304001798 putative Mg++ binding site [ion binding]; other site 561304001799 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 561304001800 membrane protein 561304001801 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 561304001802 TrkA-C domain; Region: TrkA_C; pfam02080 561304001803 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 561304001804 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 561304001810 oxidoreductase 561304001811 acyl-[ACP] desaturase 561304001812 beta-ketoadipyl-CoA thiolase 561304001813 Predicted GTPases [General function prediction only]; Region: COG1162 561304001814 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 561304001815 GTPase/Zn-binding domain interface [polypeptide binding]; other site 561304001816 GTP/Mg2+ binding site [chemical binding]; other site 561304001817 G4 box; other site 561304001818 G5 box; other site 561304001819 G1 box; other site 561304001820 Switch I region; other site 561304001821 G2 box; other site 561304001822 G3 box; other site 561304001823 Switch II region; other site 561304001824 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 561304001825 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 561304001826 hinge; other site 561304001827 active site 561304001828 Uncharacterized conserved protein [Function unknown]; Region: COG2135 561304001829 REP-family protein 561304001830 arylsulfatase 561304001831 PPE-family protein 561304001832 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 561304001833 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 561304001834 Uncharacterized conserved protein [Function unknown]; Region: EbsC; COG2606 561304001835 putative deacylase active site [active] 561304001836 oxidoreductase 561304001837 ECF subfamily sigma subunit 561304001839 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 561304001840 carboxyltransferase (CT) interaction site; other site 561304001841 biotinylation site [posttranslational modification]; other site 561304001842 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 561304001843 PAS domain S-box; Region: sensory_box; TIGR00229 561304001844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 561304001845 Histidine kinase; Region: HisKA_2; pfam07568 561304001846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304001847 ATP binding site [chemical binding]; other site 561304001848 Mg2+ binding site [ion binding]; other site 561304001849 G-X-G motif; other site 561304001850 Transcription factor WhiB; Region: Whib; pfam02467 561304001852 possible acyltransferase 561304001853 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 561304001854 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 561304001855 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 561304001857 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 561304001858 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 561304001859 ATP binding site [chemical binding]; other site 561304001860 Mg++ binding site [ion binding]; other site 561304001861 motif III; other site 561304001862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304001863 nucleotide binding region [chemical binding]; other site 561304001864 ATP-binding site [chemical binding]; other site 561304001866 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 561304001867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304001868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304001869 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 561304001870 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 561304001871 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 561304001872 ATP binding site [chemical binding]; other site 561304001873 substrate interface [chemical binding]; other site 561304001874 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 561304001875 active site residue [active] 561304001876 TIGR02569 family protein; Region: TIGR02569_actnb 561304001877 methyltransferase 561304001878 probable lipase 561304001880 probable ATP-dependent DNA helicase 561304001881 potassium channel 561304001882 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 561304001883 metal binding site 2 [ion binding]; metal-binding site 561304001884 putative DNA binding helix; other site 561304001885 metal binding site 1 [ion binding]; metal-binding site 561304001886 dimer interface [polypeptide binding]; other site 561304001887 structural Zn2+ binding site [ion binding]; other site 561304001889 glycyl-tRNA synthetase; Provisional; Region: PRK04173 561304001890 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 561304001891 motif 1; other site 561304001892 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 561304001893 active site 561304001894 motif 2; other site 561304001895 motif 3; other site 561304001896 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 561304001897 anticodon binding site; other site 561304001898 transposase 561304001899 PPE-family protein 561304001900 phospholipase C precursor 561304001901 precursor of probable membrane protein 561304001902 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 561304001903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561304001904 Zn2+ binding site [ion binding]; other site 561304001905 Mg2+ binding site [ion binding]; other site 561304001906 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 561304001907 superoxide dismutase precursor (Cu-Zn) 561304001908 DNA primase; Validated; Region: dnaG; PRK05667 561304001909 CHC2 zinc finger; Region: zf-CHC2; pfam01807 561304001910 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 561304001911 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 561304001912 active site 561304001913 metal binding site [ion binding]; metal-binding site 561304001914 interdomain interaction site; other site 561304001915 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 561304001916 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 561304001917 probable malate oxidoreductase 561304001919 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 561304001920 active site 561304001921 Zn2+ binding site [ion binding]; other site 561304001922 serine O-acetyltransferase; Region: cysE; TIGR01172 561304001923 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 561304001924 trimer interface [polypeptide binding]; other site 561304001925 active site 561304001926 substrate binding site [chemical binding]; other site 561304001927 CoA binding site [chemical binding]; other site 561304001928 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 561304001929 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 561304001930 dimer interface [polypeptide binding]; other site 561304001931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304001932 catalytic residue [active] 561304001933 TQXA domain; Region: TQXA_dom; TIGR03934 561304001934 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 561304001935 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 561304001936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304001937 catalytic residue [active] 561304001938 lipoprotein 561304001939 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 561304001940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 561304001941 ABC transporter 561304001943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561304001944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561304001945 Walker A/P-loop; other site 561304001946 ATP binding site [chemical binding]; other site 561304001947 Q-loop/lid; other site 561304001948 ABC transporter signature motif; other site 561304001949 Walker B; other site 561304001950 D-loop; other site 561304001951 H-loop/switch region; other site 561304001952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 561304001953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561304001954 Walker A/P-loop; other site 561304001955 ATP binding site [chemical binding]; other site 561304001956 Q-loop/lid; other site 561304001957 ABC transporter signature motif; other site 561304001958 Walker B; other site 561304001959 D-loop; other site 561304001960 H-loop/switch region; other site 561304001961 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 561304001962 non-specific lipid transport protein 561304001963 iron-dependent transcriptional repressor 561304001964 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 561304001965 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 561304001966 active site 561304001967 Riboflavin kinase; Region: Flavokinase; pfam01687 561304001968 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 561304001969 16S/18S rRNA binding site [nucleotide binding]; other site 561304001970 S13e-L30e interaction site [polypeptide binding]; other site 561304001971 25S rRNA binding site [nucleotide binding]; other site 561304001972 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 561304001973 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 561304001974 oligomer interface [polypeptide binding]; other site 561304001975 RNA binding site [nucleotide binding]; other site 561304001976 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 561304001977 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 561304001978 RNase E interface [polypeptide binding]; other site 561304001979 trimer interface [polypeptide binding]; other site 561304001980 active site 561304001981 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 561304001982 putative nucleic acid binding region [nucleotide binding]; other site 561304001983 G-X-X-G motif; other site 561304001984 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 561304001985 RNA binding site [nucleotide binding]; other site 561304001986 domain interface; other site 561304001987 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 561304001988 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 561304001989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 561304001990 probable oxidoreductase 561304001991 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 561304001992 lipoyl synthase; Provisional; Region: PRK05481 561304001993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561304001994 FeS/SAM binding site; other site 561304001995 lipoate-protein ligase B; Provisional; Region: PRK14345 561304001996 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 561304001997 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 561304001998 putative NAD(P) binding site [chemical binding]; other site 561304001999 putative active site [active] 561304002000 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 561304002001 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 561304002002 E3 interaction surface; other site 561304002003 lipoyl attachment site [posttranslational modification]; other site 561304002004 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 561304002005 E3 interaction surface; other site 561304002006 lipoyl attachment site [posttranslational modification]; other site 561304002007 e3 binding domain; Region: E3_binding; pfam02817 561304002008 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 561304002009 short chain dehydrogenase; Validated; Region: PRK05855 561304002010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 561304002011 classical (c) SDRs; Region: SDR_c; cd05233 561304002012 NAD(P) binding site [chemical binding]; other site 561304002013 active site 561304002014 multifunctional aminopeptidase A; Provisional; Region: PRK00913 561304002015 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 561304002016 interface (dimer of trimers) [polypeptide binding]; other site 561304002017 Substrate-binding/catalytic site; other site 561304002018 Zn-binding sites [ion binding]; other site 561304002019 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 561304002020 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 561304002021 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 561304002022 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 561304002023 homodimer interface [polypeptide binding]; other site 561304002024 substrate-cofactor binding pocket; other site 561304002025 catalytic residue [active] 561304002026 cobalamin (5'-phosphate) synthase 561304002027 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 561304002028 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 561304002029 putative dimer interface [polypeptide binding]; other site 561304002030 active site pocket [active] 561304002031 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 561304002033 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 561304002034 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 561304002035 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 561304002036 substrate binding site [chemical binding]; other site 561304002037 ATP binding site [chemical binding]; other site 561304002038 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 561304002039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 561304002040 active site 561304002041 dimer interface [polypeptide binding]; other site 561304002042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 561304002043 Ligand Binding Site [chemical binding]; other site 561304002044 Molecular Tunnel; other site 561304002045 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 561304002046 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 561304002047 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 561304002048 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 561304002049 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 561304002050 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 561304002051 heme bH binding site [chemical binding]; other site 561304002052 Qi binding site; other site 561304002053 intrachain domain interface; other site 561304002054 heme bL binding site [chemical binding]; other site 561304002055 interchain domain interface [polypeptide binding]; other site 561304002056 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 561304002057 Qo binding site; other site 561304002058 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 561304002059 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 561304002060 iron-sulfur cluster [ion binding]; other site 561304002061 [2Fe-2S] cluster binding site [ion binding]; other site 561304002062 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 561304002063 Cytochrome c; Region: Cytochrom_C; pfam00034 561304002064 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 561304002065 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 561304002066 Subunit I/III interface [polypeptide binding]; other site 561304002067 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 561304002068 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 561304002069 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 561304002071 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 561304002072 NlpC/P60 family; Region: NLPC_P60; pfam00877 561304002073 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 561304002074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561304002075 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 561304002076 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 561304002077 acyl-activating enzyme (AAE) consensus motif; other site 561304002078 putative AMP binding site [chemical binding]; other site 561304002079 putative active site [active] 561304002080 putative CoA binding site [chemical binding]; other site 561304002081 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 561304002082 putative hydrophobic ligand binding site [chemical binding]; other site 561304002083 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 561304002084 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 561304002085 P loop; other site 561304002086 Nucleotide binding site [chemical binding]; other site 561304002087 DTAP/Switch II; other site 561304002088 Switch I; other site 561304002089 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 561304002090 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 561304002091 putative acyl-acceptor binding pocket; other site 561304002092 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 561304002093 probable integral membrane protein 561304002094 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 561304002095 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 561304002096 Catalytic domain of Protein Kinases; Region: PKc; cd00180 561304002097 active site 561304002098 ATP binding site [chemical binding]; other site 561304002099 substrate binding site [chemical binding]; other site 561304002100 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 561304002101 substrate binding site [chemical binding]; other site 561304002102 activation loop (A-loop); other site 561304002103 activation loop (A-loop); other site 561304002104 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 561304002105 geranylgeranyl pyrophosphate synthase 561304002106 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 561304002107 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561304002108 Coenzyme A binding pocket [chemical binding]; other site 561304002109 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 561304002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 561304002111 MraZ protein; Region: MraZ; pfam02381 561304002112 MraZ protein; Region: MraZ; pfam02381 561304002113 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 561304002114 MraW methylase family; Region: Methyltransf_5; cl17771 561304002115 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 561304002116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 561304002117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561304002118 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 561304002119 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 561304002120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561304002121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561304002122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561304002123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561304002124 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 561304002125 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 561304002126 Mg++ binding site [ion binding]; other site 561304002127 putative catalytic motif [active] 561304002128 putative substrate binding site [chemical binding]; other site 561304002129 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 561304002130 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561304002131 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561304002132 cell division protein FtsW; Region: ftsW; TIGR02614 561304002133 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 561304002134 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 561304002135 active site 561304002136 homodimer interface [polypeptide binding]; other site 561304002137 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 561304002138 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 561304002139 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561304002140 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561304002141 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 561304002142 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 561304002143 cell division protein FtsZ; Validated; Region: PRK09330 561304002144 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 561304002145 nucleotide binding site [chemical binding]; other site 561304002146 SulA interaction site; other site 561304002147 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 561304002148 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 561304002149 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 561304002150 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561304002151 catalytic residue [active] 561304002152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 561304002153 Predicted integral membrane protein [Function unknown]; Region: COG0762 561304002154 DivIVA domain; Region: DivI1A_domain; TIGR03544 561304002155 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 561304002157 glutamine synthetase, type I; Region: GlnA; TIGR00653 561304002158 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 561304002159 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 561304002160 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 561304002161 probable magnesium transport ATPase C 561304002162 probable dehydrogenase 561304002166 flavoprotein 561304002169 Unsure01. Len: 237 bases. Part of a repeat_region (Leprep3) which has not been sequenced, correspond to position 1107576..1107812 in Mycobacterium leprae strain TN genome. 561304002174 glucose-6-phosphate 1-dehydrogenase 561304002175 6-phosphogluconate dehydrogenase (Gram +) 561304002176 possible non-heme bromoperoxidase 561304002177 hypothetical protein (pseudogene). 561304002178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304002179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304002180 possible epoxide hydrolase 561304002182 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 561304002184 pyruvate phosphate dikinase; Provisional; Region: PRK05878 561304002185 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 561304002186 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 561304002187 Predicted membrane protein [Function unknown]; Region: COG2259 561304002188 citrate synthase; Provisional; Region: PRK14033 561304002189 possible membrane transporter 561304002190 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 561304002191 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 561304002192 THF binding site; other site 561304002193 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 561304002194 substrate binding site [chemical binding]; other site 561304002195 THF binding site; other site 561304002196 zinc-binding site [ion binding]; other site 561304002197 possible transposase 561304002198 possible 561304002200 polyketide synthase (chalcone synthase-like) 561304002202 [alpha]-methyl acyl-CoA racemase 561304002203 short-chain alcohol dehydrogenase 561304002204 probable drug transport protein 561304002205 probable drug transporter 561304002206 hypothetical protein (pseudogene). 561304002208 dehydrogenase 561304002210 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 561304002211 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304002212 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 561304002213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561304002214 Coenzyme A binding pocket [chemical binding]; other site 561304002215 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 561304002216 hypothetical protein (pseudogene). 561304002220 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 561304002221 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 561304002222 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 561304002223 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 561304002224 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 561304002225 recA bacterial DNA recombination protein; Region: RecA; cl17211 561304002226 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 561304002227 protein-splicing catalytic site; other site 561304002228 thioester formation/cholesterol transfer; other site 561304002229 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 561304002230 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 561304002231 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 561304002232 recA bacterial DNA recombination protein; Region: RecA; cl17211 561304002233 protein-splicing catalytic site; other site 561304002234 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 561304002235 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 561304002236 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 561304002237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561304002238 FeS/SAM binding site; other site 561304002240 serine-threonine protein kinase 561304002242 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 561304002243 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 561304002244 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 561304002245 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 561304002246 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 561304002247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 561304002248 GTPases [General function prediction only]; Region: HflX; COG2262 561304002249 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 561304002250 HflX GTPase family; Region: HflX; cd01878 561304002251 G1 box; other site 561304002252 GTP/Mg2+ binding site [chemical binding]; other site 561304002253 Switch I region; other site 561304002254 G2 box; other site 561304002255 G3 box; other site 561304002256 Switch II region; other site 561304002257 G4 box; other site 561304002258 G5 box; other site 561304002259 possible acyl-CoA dehydrogenase 561304002260 possible transposase 561304002262 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 561304002263 LGFP repeat; Region: LGFP; pfam08310 561304002264 LGFP repeat; Region: LGFP; pfam08310 561304002265 LGFP repeat; Region: LGFP; pfam08310 561304002266 LGFP repeat; Region: LGFP; pfam08310 561304002267 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 561304002268 LexA repressor; Validated; Region: PRK00215 561304002269 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 561304002270 Catalytic site [active] 561304002271 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 561304002272 ATP cone domain; Region: ATP-cone; pfam03477 561304002273 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 561304002274 heme-binding site [chemical binding]; other site 561304002276 possible hydrolase 561304002277 PAC2 family; Region: PAC2; pfam09754 561304002278 possible dehydrogenase 561304002279 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 561304002280 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 561304002281 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 561304002282 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 561304002283 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 561304002284 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 561304002285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 561304002286 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 561304002287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561304002288 DNA binding residues [nucleotide binding] 561304002289 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 561304002290 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 561304002291 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 561304002295 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 561304002296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 561304002297 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 561304002298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561304002299 DNA binding residues [nucleotide binding] 561304002300 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561304002301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561304002302 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 561304002303 active site 561304002304 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 561304002305 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 561304002306 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 561304002307 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 561304002308 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 561304002309 trimer interface [polypeptide binding]; other site 561304002310 active site 561304002311 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 561304002314 potassium uptake protein 561304002316 possible membrane protein 561304002317 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 561304002318 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 561304002319 transmembrane helices; other site 561304002320 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 561304002321 FOG: CBS domain [General function prediction only]; Region: COG0517 561304002322 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 561304002323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 561304002324 TPP-binding site; other site 561304002325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 561304002326 PYR/PP interface [polypeptide binding]; other site 561304002327 dimer interface [polypeptide binding]; other site 561304002328 TPP binding site [chemical binding]; other site 561304002329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 561304002331 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 561304002332 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 561304002333 catalytic site [active] 561304002334 putative active site [active] 561304002335 putative substrate binding site [chemical binding]; other site 561304002336 Helicase and RNase D C-terminal; Region: HRDC; smart00341 561304002337 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 561304002338 enoyl-CoA hydratase/isomerase superfamily 561304002339 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 561304002340 substrate binding site [chemical binding]; other site 561304002341 active site 561304002342 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 561304002343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 561304002344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561304002345 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 561304002346 methyltransferase 561304002348 transposase 561304002349 resolvase 561304002351 acyl-CoA synthetase; Validated; Region: PRK07787 561304002352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304002353 acyl-activating enzyme (AAE) consensus motif; other site 561304002354 AMP binding site [chemical binding]; other site 561304002355 active site 561304002356 CoA binding site [chemical binding]; other site 561304002357 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 561304002358 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 561304002359 PE family; Region: PE; pfam00934 561304002360 Unsure02. Len: 227 bases. Part of a repeat_region which has not been sequenced, correspond to position 1220624..1220850 in Mycobacterium leprae strain TN genome. 561304002361 possible PPE-family protein 561304002362 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 561304002363 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 561304002364 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 561304002365 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 561304002366 putative trimer interface [polypeptide binding]; other site 561304002367 putative CoA binding site [chemical binding]; other site 561304002368 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 561304002369 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 561304002370 metal binding site [ion binding]; metal-binding site 561304002371 putative dimer interface [polypeptide binding]; other site 561304002373 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 561304002374 acyl CoA-ligase 561304002375 dihydropteroate synthase; Region: DHPS; TIGR01496 561304002376 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 561304002377 substrate binding pocket [chemical binding]; other site 561304002378 dimer interface [polypeptide binding]; other site 561304002379 inhibitor binding site; inhibition site 561304002380 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 561304002381 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 561304002382 DivIVA domain; Region: DivI1A_domain; TIGR03544 561304002383 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 561304002384 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 561304002386 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 561304002387 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 561304002388 ligand binding site; other site 561304002389 oligomer interface; other site 561304002390 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 561304002391 dimer interface [polypeptide binding]; other site 561304002392 N-terminal domain interface [polypeptide binding]; other site 561304002393 sulfate 1 binding site; other site 561304002394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304002395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304002397 probable integral membrane protein 561304002398 probable ABC transmembrane transport protein 561304002399 transcriptional regulator 561304002400 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 561304002401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304002402 S-adenosylmethionine binding site [chemical binding]; other site 561304002403 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 561304002404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 561304002405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561304002406 DNA binding residues [nucleotide binding] 561304002407 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 561304002408 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 561304002409 protein binding site [polypeptide binding]; other site 561304002410 sec-independent translocase; Provisional; Region: PRK03100 561304002411 Domain of unknown function DUF59; Region: DUF59; pfam01883 561304002412 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 561304002413 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 561304002414 possible membrane protein 561304002419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561304002420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561304002421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 561304002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304002423 dimer interface [polypeptide binding]; other site 561304002424 conserved gate region; other site 561304002425 putative PBP binding loops; other site 561304002426 ABC-ATPase subunit interface; other site 561304002427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561304002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304002429 dimer interface [polypeptide binding]; other site 561304002430 conserved gate region; other site 561304002431 ABC-ATPase subunit interface; other site 561304002432 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 561304002433 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 561304002434 Walker A/P-loop; other site 561304002435 ATP binding site [chemical binding]; other site 561304002436 Q-loop/lid; other site 561304002437 ABC transporter signature motif; other site 561304002438 Walker B; other site 561304002439 D-loop; other site 561304002440 H-loop/switch region; other site 561304002441 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 561304002442 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 561304002443 oligomer interface [polypeptide binding]; other site 561304002444 metal binding site [ion binding]; metal-binding site 561304002445 metal binding site [ion binding]; metal-binding site 561304002446 putative Cl binding site [ion binding]; other site 561304002447 basic sphincter; other site 561304002448 hydrophobic gate; other site 561304002449 periplasmic entrance; other site 561304002450 malate dehydrogenase; Provisional; Region: PRK05442 561304002451 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 561304002452 NAD(P) binding site [chemical binding]; other site 561304002453 dimer interface [polypeptide binding]; other site 561304002454 malate binding site [chemical binding]; other site 561304002455 PE_PGRS-family protein 561304002456 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 561304002457 classical (c) SDRs; Region: SDR_c; cd05233 561304002458 NAD(P) binding site [chemical binding]; other site 561304002459 active site 561304002460 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 561304002461 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 561304002462 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 561304002463 TPP-binding site [chemical binding]; other site 561304002464 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 561304002465 dimer interface [polypeptide binding]; other site 561304002466 PYR/PP interface [polypeptide binding]; other site 561304002467 TPP binding site [chemical binding]; other site 561304002468 probable drug efflux protein 561304002469 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 561304002470 RNase_H superfamily; Region: RNase_H_2; pfam13482 561304002471 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 561304002472 Part of AAA domain; Region: AAA_19; pfam13245 561304002473 AAA domain; Region: AAA_12; pfam13087 561304002474 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 561304002475 possible ATP-dependent DNA/RNA helicase 561304002476 Acyltransferase family; Region: Acyl_transf_3; pfam01757 561304002477 possible cytochrome P-450 561304002478 FAD binding domain; Region: FAD_binding_4; pfam01565 561304002479 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 561304002480 probable multidrug resistance pump 561304002481 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 561304002482 Fe-S cluster binding site [ion binding]; other site 561304002483 DNA binding site [nucleotide binding] 561304002484 active site 561304002485 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 561304002487 probable aminotransferase 561304002488 amidase AMI2_MYCTU Q11056 561304002490 similar to adenylate cyclases 561304002492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561304002493 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 561304002494 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 561304002495 Walker A/P-loop; other site 561304002496 ATP binding site [chemical binding]; other site 561304002497 Q-loop/lid; other site 561304002498 ABC transporter signature motif; other site 561304002499 Walker B; other site 561304002500 D-loop; other site 561304002501 H-loop/switch region; other site 561304002502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561304002503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561304002504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304002505 Walker A/P-loop; other site 561304002506 ATP binding site [chemical binding]; other site 561304002507 Q-loop/lid; other site 561304002508 ABC transporter signature motif; other site 561304002509 Walker B; other site 561304002510 D-loop; other site 561304002511 H-loop/switch region; other site 561304002512 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 561304002513 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 561304002514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304002515 catalytic core [active] 561304002517 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 561304002518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 561304002519 active site 561304002520 metal binding site [ion binding]; metal-binding site 561304002521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304002522 Walker A/P-loop; other site 561304002523 ATP binding site [chemical binding]; other site 561304002524 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 561304002525 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 561304002526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 561304002527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 561304002528 Walker A/P-loop; other site 561304002529 ATP binding site [chemical binding]; other site 561304002530 Q-loop/lid; other site 561304002531 ABC transporter signature motif; other site 561304002532 Walker B; other site 561304002533 D-loop; other site 561304002534 H-loop/switch region; other site 561304002535 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 561304002536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 561304002537 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 561304002538 Walker A/P-loop; other site 561304002539 ATP binding site [chemical binding]; other site 561304002540 Q-loop/lid; other site 561304002541 ABC transporter signature motif; other site 561304002542 Walker B; other site 561304002543 D-loop; other site 561304002544 H-loop/switch region; other site 561304002545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 561304002546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 561304002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304002548 dimer interface [polypeptide binding]; other site 561304002549 conserved gate region; other site 561304002550 putative PBP binding loops; other site 561304002551 ABC-ATPase subunit interface; other site 561304002552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 561304002553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304002554 dimer interface [polypeptide binding]; other site 561304002555 putative PBP binding loops; other site 561304002556 ABC-ATPase subunit interface; other site 561304002558 lipoprotein 561304002559 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 561304002560 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 561304002561 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 561304002562 active site 561304002563 HIGH motif; other site 561304002564 KMSK motif region; other site 561304002565 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 561304002566 tRNA binding surface [nucleotide binding]; other site 561304002567 anticodon binding site; other site 561304002568 diaminopimelate decarboxylase; Region: lysA; TIGR01048 561304002569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 561304002570 active site 561304002571 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561304002572 substrate binding site [chemical binding]; other site 561304002573 catalytic residues [active] 561304002574 dimer interface [polypeptide binding]; other site 561304002575 homoserine dehydrogenase; Provisional; Region: PRK06349 561304002576 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 561304002577 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 561304002578 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 561304002579 threonine synthase; Reviewed; Region: PRK06721 561304002580 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 561304002581 homodimer interface [polypeptide binding]; other site 561304002582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304002583 catalytic residue [active] 561304002584 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 561304002585 transcription termination factor Rho; Provisional; Region: PRK12678 561304002586 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 561304002587 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 561304002588 RNA binding site [nucleotide binding]; other site 561304002589 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 561304002590 multimer interface [polypeptide binding]; other site 561304002591 Walker A motif; other site 561304002592 ATP binding site [chemical binding]; other site 561304002593 Walker B motif; other site 561304002594 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 561304002595 peptide chain release factor 1; Region: prfA; TIGR00019 561304002596 PCRF domain; Region: PCRF; pfam03462 561304002597 RF-1 domain; Region: RF-1; pfam00472 561304002598 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 561304002599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304002600 S-adenosylmethionine binding site [chemical binding]; other site 561304002601 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 561304002602 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 561304002603 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 561304002604 Mg++ binding site [ion binding]; other site 561304002605 putative catalytic motif [active] 561304002606 substrate binding site [chemical binding]; other site 561304002607 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 561304002608 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 561304002609 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 561304002610 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 561304002611 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 561304002612 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 561304002613 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 561304002614 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 561304002615 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 561304002616 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 561304002617 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561304002618 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 561304002619 beta subunit interaction interface [polypeptide binding]; other site 561304002620 Walker A motif; other site 561304002621 ATP binding site [chemical binding]; other site 561304002622 Walker B motif; other site 561304002623 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561304002624 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 561304002625 core domain interface [polypeptide binding]; other site 561304002626 delta subunit interface [polypeptide binding]; other site 561304002627 epsilon subunit interface [polypeptide binding]; other site 561304002628 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 561304002629 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561304002630 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 561304002631 alpha subunit interaction interface [polypeptide binding]; other site 561304002632 Walker A motif; other site 561304002633 ATP binding site [chemical binding]; other site 561304002634 Walker B motif; other site 561304002635 inhibitor binding site; inhibition site 561304002636 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561304002637 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 561304002638 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 561304002639 gamma subunit interface [polypeptide binding]; other site 561304002640 epsilon subunit interface [polypeptide binding]; other site 561304002641 LBP interface [polypeptide binding]; other site 561304002642 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 561304002643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 561304002644 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 561304002645 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 561304002646 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 561304002647 hinge; other site 561304002648 active site 561304002649 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 561304002650 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 561304002651 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 561304002652 DNA binding site [nucleotide binding] 561304002653 active site 561304002654 DNA-3-methyladenine glycosidase II 561304002655 probable oxidoreductase 561304002657 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 561304002658 hypothetical protein; Provisional; Region: PRK03298 561304002660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 561304002661 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 561304002662 dimer interface [polypeptide binding]; other site 561304002663 substrate binding site [chemical binding]; other site 561304002664 metal binding site [ion binding]; metal-binding site 561304002665 putative acyltransferase; Provisional; Region: PRK05790 561304002666 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 561304002667 dimer interface [polypeptide binding]; other site 561304002668 active site 561304002669 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 561304002670 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 561304002671 1,4-[alpha]-glucan branching enzyme 561304002673 possible glycogen phosphorylase 561304002674 possible antibiotic efflux protein 561304002676 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 561304002677 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 561304002678 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 561304002679 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 561304002680 cleavage site 561304002683 cysteine synthase B 561304002684 Rhomboid family; Region: Rhomboid; pfam01694 561304002685 glutamate racemase; Provisional; Region: PRK00865 561304002686 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 561304002687 ribonuclease PH; Reviewed; Region: rph; PRK00173 561304002688 Ribonuclease PH; Region: RNase_PH_bact; cd11362 561304002689 hexamer interface [polypeptide binding]; other site 561304002690 active site 561304002691 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 561304002692 active site 561304002693 dimerization interface [polypeptide binding]; other site 561304002694 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 561304002695 Glucitol operon activator [Transcription]; Region: GutM; COG4578 561304002696 possible 3-oxoacyl-[ACP] reductase 561304002697 possible acyl-CoA dehydrogenase 561304002698 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 561304002699 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 561304002700 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304002701 PPE family; Region: PPE; pfam00823 561304002702 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 561304002703 PE family; Region: PE; pfam00934 561304002704 zinc-containing alcohol dehydrogenase 561304002705 probable cytochrome p450 561304002706 acyl-CoA synthase 561304002707 Transcriptional regulators [Transcription]; Region: FadR; COG2186 561304002708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 561304002709 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 561304002710 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 561304002711 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 561304002712 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 561304002713 phosphate binding site [ion binding]; other site 561304002714 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 561304002715 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 561304002716 putative active site [active] 561304002717 putative catalytic site [active] 561304002718 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 561304002719 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 561304002720 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 561304002721 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 561304002722 putative NAD(P) binding site [chemical binding]; other site 561304002723 active site 561304002724 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 561304002725 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 561304002726 active site 561304002727 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 561304002728 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 561304002729 hypothetical protein; Provisional; Region: PRK08201 561304002730 active site 561304002731 metal binding site [ion binding]; metal-binding site 561304002732 dimer interface [polypeptide binding]; other site 561304002734 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 561304002735 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 561304002736 HIGH motif; other site 561304002737 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 561304002738 active site 561304002739 KMSKS motif; other site 561304002740 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 561304002741 tRNA binding surface [nucleotide binding]; other site 561304002742 anticodon binding site; other site 561304002744 probable DNA-damage-inducible protein 561304002745 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 561304002746 active site 561304002747 homotetramer interface [polypeptide binding]; other site 561304002748 homodimer interface [polypeptide binding]; other site 561304002749 lipoprotein signal peptidase; Provisional; Region: PRK14764 561304002750 lipoprotein signal peptidase; Provisional; Region: PRK14787 561304002751 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 561304002752 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 561304002753 active site 561304002755 lipoprotein 561304002756 hemoglobin-like, oxygen carrier 561304002757 probable fatty-acyl CoA reductase 561304002758 probable ketoacyl reductase 561304002760 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 561304002761 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 561304002762 active site 561304002763 PHP Thumb interface [polypeptide binding]; other site 561304002764 metal binding site [ion binding]; metal-binding site 561304002765 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 561304002766 generic binding surface II; other site 561304002767 generic binding surface I; other site 561304002769 threonine dehydratase; Validated; Region: PRK08639 561304002770 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 561304002771 tetramer interface [polypeptide binding]; other site 561304002772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304002773 catalytic residue [active] 561304002774 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 561304002775 putative Ile/Val binding site [chemical binding]; other site 561304002776 [alpha]-amylase 561304002777 probable glycogen debranching enzyme 561304002778 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 561304002779 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 561304002780 NlpC/P60 family; Region: NLPC_P60; pfam00877 561304002782 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 561304002783 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 561304002784 inhibitor-cofactor binding pocket; inhibition site 561304002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304002786 catalytic residue [active] 561304002787 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 561304002788 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 561304002789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304002790 catalytic residue [active] 561304002791 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 561304002793 biotin synthase; Validated; Region: PRK06256 561304002794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561304002795 FeS/SAM binding site; other site 561304002796 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 561304002797 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 561304002799 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 561304002800 nudix motif; other site 561304002801 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 561304002802 quinolinate synthetase; Provisional; Region: PRK09375 561304002803 L-aspartate oxidase; Provisional; Region: PRK07804 561304002804 L-aspartate oxidase; Provisional; Region: PRK06175 561304002805 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 561304002806 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 561304002807 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 561304002808 dimerization interface [polypeptide binding]; other site 561304002809 active site 561304002810 probable esterase 561304002811 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304002812 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304002813 active site 561304002814 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 561304002815 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304002816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304002817 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 561304002818 Enoylreductase; Region: PKS_ER; smart00829 561304002819 NAD(P) binding site [chemical binding]; other site 561304002820 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 561304002821 KR domain; Region: KR; pfam08659 561304002822 putative NADP binding site [chemical binding]; other site 561304002823 active site 561304002824 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304002825 Condensation domain; Region: Condensation; pfam00668 561304002826 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 561304002827 PE-PPE domain; Region: PE-PPE; pfam08237 561304002828 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 561304002829 acyl-CoA synthetase; Validated; Region: PRK05850 561304002830 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304002831 acyl-activating enzyme (AAE) consensus motif; other site 561304002832 active site 561304002833 polyketide synthase 561304002834 polyketide synthase (chalcone synthase-like) 561304002835 possible cytochrome P450 561304002836 Probable cytochrome p450 561304002837 Probable ABC transporter 561304002838 probable ABC transporter 561304002839 enoyl-CoA hydratase; Provisional; Region: PRK05864 561304002840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304002841 substrate binding site [chemical binding]; other site 561304002842 oxyanion hole (OAH) forming residues; other site 561304002843 trimer interface [polypeptide binding]; other site 561304002844 transcriptional regulator (LuxR/UhpA family) 561304002845 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 561304002846 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 561304002847 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 561304002848 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 561304002849 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 561304002850 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 561304002851 putative acyl-acceptor binding pocket; other site 561304002852 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 561304002853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 561304002854 putative acyl-acceptor binding pocket; other site 561304002856 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 561304002857 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304002858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304002859 ABC transporter; Region: ABC_tran_2; pfam12848 561304002860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304002861 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 561304002864 probable maltase [alpha]-glucosidase 561304002865 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 561304002866 apolar tunnel; other site 561304002867 heme binding site [chemical binding]; other site 561304002868 dimerization interface [polypeptide binding]; other site 561304002869 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 561304002870 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 561304002871 active site 561304002873 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 561304002874 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 561304002875 NAD binding site [chemical binding]; other site 561304002876 dimerization interface [polypeptide binding]; other site 561304002877 product binding site; other site 561304002878 substrate binding site [chemical binding]; other site 561304002879 zinc binding site [ion binding]; other site 561304002880 catalytic residues [active] 561304002881 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 561304002882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561304002883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304002884 homodimer interface [polypeptide binding]; other site 561304002885 catalytic residue [active] 561304002886 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 561304002887 putative active site pocket [active] 561304002888 4-fold oligomerization interface [polypeptide binding]; other site 561304002889 metal binding residues [ion binding]; metal-binding site 561304002890 3-fold/trimer interface [polypeptide binding]; other site 561304002891 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 561304002892 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 561304002893 putative active site [active] 561304002894 oxyanion strand; other site 561304002895 catalytic triad [active] 561304002896 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 561304002897 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 561304002898 catalytic residues [active] 561304002899 impA, inositol monophosphtase 561304002900 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 561304002901 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 561304002902 substrate binding site [chemical binding]; other site 561304002903 glutamase interaction surface [polypeptide binding]; other site 561304002904 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 561304002905 possible membrane protein 561304002906 serine-threonine protein kinase 561304002907 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 561304002908 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 561304002909 (bacterioferritin comigratory protein) 561304002910 anthranilate synthase component I; Provisional; Region: PRK13571 561304002911 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 561304002912 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 561304002913 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 561304002914 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 561304002915 active site 561304002916 ribulose/triose binding site [chemical binding]; other site 561304002917 phosphate binding site [ion binding]; other site 561304002918 substrate (anthranilate) binding pocket [chemical binding]; other site 561304002919 product (indole) binding pocket [chemical binding]; other site 561304002920 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 561304002921 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 561304002922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304002923 catalytic residue [active] 561304002924 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 561304002925 substrate binding site [chemical binding]; other site 561304002926 active site 561304002927 catalytic residues [active] 561304002928 heterodimer interface [polypeptide binding]; other site 561304002929 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 561304002930 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 561304002931 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 561304002932 pyruvate kinase; Provisional; Region: PRK06247 561304002933 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 561304002934 domain interfaces; other site 561304002935 active site 561304002936 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 561304002937 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 561304002938 active site 561304002939 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 561304002940 catalytic triad [active] 561304002941 dimer interface [polypeptide binding]; other site 561304002943 short-chain alcohol dehydrogenase 561304002944 ABC transporter 561304002945 ABC transporter 561304002946 cytochrome d ubiquinol oxidase subunit II 561304002947 cytochrome bd-II oxidase subunit I 561304002948 C-term similar eukaryotic adenylate/guanylate cyclases 561304002949 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 561304002950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561304002951 active site 561304002952 phosphorylation site [posttranslational modification] 561304002953 intermolecular recognition site; other site 561304002954 dimerization interface [polypeptide binding]; other site 561304002955 ANTAR domain; Region: ANTAR; pfam03861 561304002956 lipid carrier protein 561304002957 hypothetical protein; Provisional; Region: PRK07906 561304002958 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 561304002959 putative metal binding site [ion binding]; other site 561304002960 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 561304002961 substrate binding site [chemical binding]; other site 561304002963 transposase 561304002964 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 561304002965 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 561304002966 quinone interaction residues [chemical binding]; other site 561304002967 active site 561304002968 catalytic residues [active] 561304002969 FMN binding site [chemical binding]; other site 561304002970 substrate binding site [chemical binding]; other site 561304002972 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 561304002973 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304002974 catalytic core [active] 561304002975 conserved hypothetical protein; Region: TIGR03847 561304002976 conserved hypothetical protein; Region: TIGR03843 561304002977 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 561304002978 active site 561304002979 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 561304002980 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304002981 active site 561304002982 HIGH motif; other site 561304002983 nucleotide binding site [chemical binding]; other site 561304002984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304002985 active site 561304002986 KMSKS motif; other site 561304002987 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 561304002988 putative tRNA binding surface [nucleotide binding]; other site 561304002989 oxidoreductase 561304002990 L-asparagine permease; Provisional; Region: PRK15049 561304002991 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 561304002992 PAC2 family; Region: PAC2; pfam09754 561304002993 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 561304002994 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 561304002995 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 561304002996 substrate binding pocket [chemical binding]; other site 561304002997 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 561304002998 B12 binding site [chemical binding]; other site 561304002999 cobalt ligand [ion binding]; other site 561304003000 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 561304003001 PPE-family protein 561304003002 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 561304003003 homodimer interface [polypeptide binding]; other site 561304003004 putative metal binding site [ion binding]; other site 561304003005 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 561304003006 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 561304003007 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 561304003009 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 561304003010 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 561304003011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304003012 S-adenosylmethionine binding site [chemical binding]; other site 561304003013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 561304003014 proteasome ATPase; Region: pup_AAA; TIGR03689 561304003015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304003016 Walker A motif; other site 561304003017 ATP binding site [chemical binding]; other site 561304003018 Walker B motif; other site 561304003019 arginine finger; other site 561304003021 possible integral membrane protein 561304003022 similar to phytoene dehydrogenase precursor 561304003023 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 561304003024 Pup-like protein; Region: Pup; pfam05639 561304003025 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 561304003026 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 561304003027 active site 561304003028 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 561304003029 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 561304003030 active site 561304003035 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 561304003036 Predicted transcriptional regulator [Transcription]; Region: COG2378 561304003037 WYL domain; Region: WYL; pfam13280 561304003038 Predicted transcriptional regulator [Transcription]; Region: COG2378 561304003039 WYL domain; Region: WYL; pfam13280 561304003040 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 561304003041 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 561304003042 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 561304003043 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 561304003044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304003045 ATP binding site [chemical binding]; other site 561304003046 putative Mg++ binding site [ion binding]; other site 561304003047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304003048 nucleotide binding region [chemical binding]; other site 561304003049 ATP-binding site [chemical binding]; other site 561304003050 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 561304003051 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 561304003052 partially similar to DNA polymerase I 561304003053 cytoplasmic peptidase 561304003054 Unsure03. Len: 315 bases. Part of a repeat_region (Rlep8) which has not been sequenced, correspond to position 1593475..1593789 in Mycobacterium leprae strain TN genome. 561304003056 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 561304003057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 561304003058 TAP-like protein; Region: Abhydrolase_4; pfam08386 561304003059 hypothetical protein; Provisional; Region: PRK14059 561304003060 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 561304003064 transcriptional regulator (LuxR/UhpA family) 561304003065 acyl-CoA synthetase; Validated; Region: PRK07868 561304003066 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 561304003067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304003068 acyl-activating enzyme (AAE) consensus motif; other site 561304003069 AMP binding site [chemical binding]; other site 561304003070 active site 561304003071 CoA binding site [chemical binding]; other site 561304003072 Uncharacterized conserved protein [Function unknown]; Region: COG2835 561304003074 probable transmembrane protein 561304003075 probable ABC transporter 561304003076 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 561304003077 active site 561304003078 DNA binding site [nucleotide binding] 561304003079 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 561304003080 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 561304003081 active site 561304003082 HIGH motif; other site 561304003083 dimer interface [polypeptide binding]; other site 561304003084 KMSKS motif; other site 561304003085 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561304003086 RNA binding surface [nucleotide binding]; other site 561304003090 probable hydrolase 561304003091 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 561304003092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561304003093 RNA binding surface [nucleotide binding]; other site 561304003094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304003095 S-adenosylmethionine binding site [chemical binding]; other site 561304003096 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 561304003097 ATP-NAD kinase; Region: NAD_kinase; pfam01513 561304003098 DNA repair protein RecN; Region: recN; TIGR00634 561304003099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304003100 Walker A/P-loop; other site 561304003101 ATP binding site [chemical binding]; other site 561304003102 Q-loop/lid; other site 561304003103 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 561304003104 ABC transporter signature motif; other site 561304003105 Walker B; other site 561304003106 D-loop; other site 561304003107 H-loop/switch region; other site 561304003108 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 561304003109 Thiamine pyrophosphokinase; Region: TPK; cl08415 561304003110 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 561304003111 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 561304003112 CTP synthetase; Validated; Region: pyrG; PRK05380 561304003113 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 561304003114 Catalytic site [active] 561304003115 active site 561304003116 UTP binding site [chemical binding]; other site 561304003117 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 561304003118 active site 561304003119 putative oxyanion hole; other site 561304003120 catalytic triad [active] 561304003122 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 561304003123 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 561304003124 active site 561304003125 Int/Topo IB signature motif; other site 561304003126 methyltransferase 561304003127 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 561304003128 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 561304003129 P-loop; other site 561304003130 Magnesium ion binding site [ion binding]; other site 561304003131 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 561304003132 Magnesium ion binding site [ion binding]; other site 561304003133 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 561304003134 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 561304003135 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 561304003136 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561304003137 RNA binding surface [nucleotide binding]; other site 561304003138 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 561304003139 active site 561304003140 cytidylate kinase; Provisional; Region: cmk; PRK00023 561304003141 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 561304003142 CMP-binding site; other site 561304003143 The sites determining sugar specificity; other site 561304003144 GTP-binding protein Der; Reviewed; Region: PRK03003 561304003145 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 561304003146 G1 box; other site 561304003147 GTP/Mg2+ binding site [chemical binding]; other site 561304003148 Switch I region; other site 561304003149 G2 box; other site 561304003150 Switch II region; other site 561304003151 G3 box; other site 561304003152 G4 box; other site 561304003153 G5 box; other site 561304003154 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 561304003155 G1 box; other site 561304003156 GTP/Mg2+ binding site [chemical binding]; other site 561304003157 Switch I region; other site 561304003158 G2 box; other site 561304003159 G3 box; other site 561304003160 Switch II region; other site 561304003161 G4 box; other site 561304003162 G5 box; other site 561304003165 transcriptional regulator (IclR family) 561304003166 probable aminoglycoside 3'-phosphotransferases 561304003169 oxidoreductase, possible 561304003170 DNA polymerase I; Provisional; Region: PRK05755 561304003171 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 561304003172 active site 561304003173 metal binding site 1 [ion binding]; metal-binding site 561304003174 putative 5' ssDNA interaction site; other site 561304003175 metal binding site 3; metal-binding site 561304003176 metal binding site 2 [ion binding]; metal-binding site 561304003177 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 561304003178 putative DNA binding site [nucleotide binding]; other site 561304003179 putative metal binding site [ion binding]; other site 561304003180 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 561304003181 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 561304003182 active site 561304003183 DNA binding site [nucleotide binding] 561304003184 catalytic site [active] 561304003185 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 561304003186 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 561304003187 RNA binding site [nucleotide binding]; other site 561304003188 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 561304003189 RNA binding site [nucleotide binding]; other site 561304003190 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 561304003191 RNA binding site [nucleotide binding]; other site 561304003192 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 561304003193 RNA binding site [nucleotide binding]; other site 561304003194 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 561304003195 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 561304003196 CoA-binding site [chemical binding]; other site 561304003197 ATP-binding [chemical binding]; other site 561304003198 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 561304003199 ABC transporter 561304003200 serine-threonine protein kinase 561304003201 excinuclease ABC subunit B; Provisional; Region: PRK05298 561304003202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304003203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304003204 nucleotide binding region [chemical binding]; other site 561304003205 ATP-binding site [chemical binding]; other site 561304003206 Ultra-violet resistance protein B; Region: UvrB; pfam12344 561304003207 UvrB/uvrC motif; Region: UVR; pfam02151 561304003208 probable drug efflux protein 561304003209 Predicted membrane protein [Function unknown]; Region: COG5305 561304003210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 561304003211 Ligand Binding Site [chemical binding]; other site 561304003212 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 561304003213 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 561304003214 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 561304003215 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 561304003216 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 561304003217 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 561304003218 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 561304003219 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 561304003220 dimer interface [polypeptide binding]; other site 561304003221 putative anticodon binding site; other site 561304003222 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 561304003223 motif 1; other site 561304003224 dimer interface [polypeptide binding]; other site 561304003225 active site 561304003226 motif 2; other site 561304003227 motif 3; other site 561304003228 translation initiation factor IF-3; Region: infC; TIGR00168 561304003229 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 561304003230 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 561304003231 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 561304003232 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 561304003233 23S rRNA binding site [nucleotide binding]; other site 561304003234 L21 binding site [polypeptide binding]; other site 561304003235 L13 binding site [polypeptide binding]; other site 561304003236 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 561304003237 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 561304003238 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 561304003240 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 561304003241 cyclase homology domain; Region: CHD; cd07302 561304003242 nucleotidyl binding site; other site 561304003243 metal binding site [ion binding]; metal-binding site 561304003244 dimer interface [polypeptide binding]; other site 561304003245 possible membrane protein 561304003246 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 561304003247 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 561304003248 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 561304003249 dimer interface [polypeptide binding]; other site 561304003250 motif 1; other site 561304003251 active site 561304003252 motif 2; other site 561304003253 motif 3; other site 561304003254 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 561304003255 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 561304003256 putative tRNA-binding site [nucleotide binding]; other site 561304003257 B3/4 domain; Region: B3_4; pfam03483 561304003258 tRNA synthetase B5 domain; Region: B5; smart00874 561304003259 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 561304003260 dimer interface [polypeptide binding]; other site 561304003261 motif 1; other site 561304003262 motif 3; other site 561304003263 motif 2; other site 561304003264 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 561304003265 PE-family protein 561304003266 transposase 561304003267 transposase 561304003268 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 561304003269 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 561304003270 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 561304003271 heterotetramer interface [polypeptide binding]; other site 561304003272 active site pocket [active] 561304003273 cleavage site 561304003274 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 561304003275 feedback inhibition sensing region; other site 561304003276 homohexameric interface [polypeptide binding]; other site 561304003277 nucleotide binding site [chemical binding]; other site 561304003278 N-acetyl-L-glutamate binding site [chemical binding]; other site 561304003279 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 561304003280 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 561304003281 inhibitor-cofactor binding pocket; inhibition site 561304003282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304003283 catalytic residue [active] 561304003284 ornithine carbamoyltransferase; Provisional; Region: PRK00779 561304003285 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 561304003286 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 561304003287 arginine repressor; Provisional; Region: PRK03341 561304003288 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 561304003289 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 561304003290 argininosuccinate synthase; Provisional; Region: PRK13820 561304003291 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 561304003292 ANP binding site [chemical binding]; other site 561304003293 Substrate Binding Site II [chemical binding]; other site 561304003294 Substrate Binding Site I [chemical binding]; other site 561304003295 argininosuccinate lyase; Provisional; Region: PRK00855 561304003296 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 561304003297 active sites [active] 561304003298 tetramer interface [polypeptide binding]; other site 561304003299 PGRS-family protein 561304003300 polyketide synthase (chalcone synthase-like) 561304003301 polyketide synthase 561304003302 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 561304003303 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 561304003304 putative catalytic residue [active] 561304003305 PAS domain S-box; Region: sensory_box; TIGR00229 561304003306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 561304003307 putative active site [active] 561304003308 heme pocket [chemical binding]; other site 561304003309 PAS domain S-box; Region: sensory_box; TIGR00229 561304003310 PAS domain; Region: PAS; smart00091 561304003311 PAS domain; Region: PAS_8; pfam13188 561304003312 PAS domain; Region: PAS_9; pfam13426 561304003313 putative active site [active] 561304003314 heme pocket [chemical binding]; other site 561304003315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 561304003316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 561304003317 metal binding site [ion binding]; metal-binding site 561304003318 active site 561304003319 I-site; other site 561304003322 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 561304003323 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 561304003324 active site 561304003325 nucleophile elbow; other site 561304003326 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 561304003327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304003328 Walker A/P-loop; other site 561304003329 ATP binding site [chemical binding]; other site 561304003330 Q-loop/lid; other site 561304003331 ABC transporter signature motif; other site 561304003332 Walker B; other site 561304003333 D-loop; other site 561304003334 H-loop/switch region; other site 561304003335 TOBE domain; Region: TOBE_2; pfam08402 561304003336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561304003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304003338 dimer interface [polypeptide binding]; other site 561304003339 conserved gate region; other site 561304003340 putative PBP binding loops; other site 561304003341 ABC-ATPase subunit interface; other site 561304003342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561304003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304003344 dimer interface [polypeptide binding]; other site 561304003345 conserved gate region; other site 561304003346 putative PBP binding loops; other site 561304003347 ABC-ATPase subunit interface; other site 561304003348 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561304003349 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 561304003350 ECF family sigma factor 561304003351 DoxX-like family; Region: DoxX_2; pfam13564 561304003353 pyrazinamide resistance/sensitivity 561304003355 probable carboxylesterase 561304003356 probable lipoprotein 561304003358 polyketide synthase 561304003360 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 561304003361 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 561304003362 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 561304003363 Ligand binding site; other site 561304003364 Putative Catalytic site; other site 561304003365 DXD motif; other site 561304003366 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 561304003367 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 561304003368 putative active site [active] 561304003369 catalytic triad [active] 561304003370 putative dimer interface [polypeptide binding]; other site 561304003373 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 561304003374 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 561304003375 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 561304003376 cobalt insertion 561304003377 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 561304003378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 561304003379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561304003380 DNA binding residues [nucleotide binding] 561304003381 precorrin reductase 561304003382 precorrin-3 methylase 561304003384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304003385 catalytic core [active] 561304003386 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 561304003387 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 561304003388 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 561304003389 active site 561304003390 (T/H)XGH motif; other site 561304003394 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 561304003395 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 561304003396 putative catalytic cysteine [active] 561304003397 possible monooxygenasemonoxygenase 561304003399 ribokinase 561304003401 NAD synthetase; Reviewed; Region: nadE; PRK02628 561304003402 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 561304003403 multimer interface [polypeptide binding]; other site 561304003404 active site 561304003405 catalytic triad [active] 561304003406 protein interface 1 [polypeptide binding]; other site 561304003407 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 561304003408 homodimer interface [polypeptide binding]; other site 561304003409 NAD binding pocket [chemical binding]; other site 561304003410 ATP binding pocket [chemical binding]; other site 561304003411 Mg binding site [ion binding]; other site 561304003412 active-site loop [active] 561304003413 gamma-glutamyl kinase; Provisional; Region: PRK05429 561304003414 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 561304003415 nucleotide binding site [chemical binding]; other site 561304003416 homotetrameric interface [polypeptide binding]; other site 561304003417 putative phosphate binding site [ion binding]; other site 561304003418 putative allosteric binding site; other site 561304003419 PUA domain; Region: PUA; pfam01472 561304003420 GTPase CgtA; Reviewed; Region: obgE; PRK12296 561304003421 GTP1/OBG; Region: GTP1_OBG; pfam01018 561304003422 Obg GTPase; Region: Obg; cd01898 561304003423 G1 box; other site 561304003424 GTP/Mg2+ binding site [chemical binding]; other site 561304003425 Switch I region; other site 561304003426 G2 box; other site 561304003427 G3 box; other site 561304003428 Switch II region; other site 561304003429 G4 box; other site 561304003430 G5 box; other site 561304003431 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 561304003432 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 561304003433 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 561304003434 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 561304003435 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 561304003436 homodimer interface [polypeptide binding]; other site 561304003437 oligonucleotide binding site [chemical binding]; other site 561304003438 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 561304003439 active site 561304003440 multimer interface [polypeptide binding]; other site 561304003441 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 561304003442 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 561304003443 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 561304003444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304003445 active site 561304003446 HIGH motif; other site 561304003447 nucleotide binding site [chemical binding]; other site 561304003448 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 561304003449 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 561304003450 active site 561304003451 KMSKS motif; other site 561304003452 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 561304003453 tRNA binding surface [nucleotide binding]; other site 561304003454 anticodon binding site; other site 561304003455 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 561304003458 oxidoreductase, beta subunit 561304003459 probable oxidoreductase alpha subunit 561304003460 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 561304003461 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 561304003462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304003463 Walker A motif; other site 561304003464 ATP binding site [chemical binding]; other site 561304003465 Walker B motif; other site 561304003466 arginine finger; other site 561304003467 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 561304003468 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 561304003469 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 561304003470 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 561304003471 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 561304003472 oligomer interface [polypeptide binding]; other site 561304003473 active site residues [active] 561304003474 Clp protease; Region: CLP_protease; pfam00574 561304003475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 561304003476 oligomer interface [polypeptide binding]; other site 561304003477 active site residues [active] 561304003478 trigger factor; Provisional; Region: tig; PRK01490 561304003479 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 561304003480 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 561304003481 probable esterase 561304003482 probable DNA glycosylase, endonuclease VIII 561304003483 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 561304003484 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 561304003485 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 561304003486 catalytic residues [active] 561304003487 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 561304003488 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 561304003489 Zn binding site [ion binding]; other site 561304003490 possible transport protein 561304003491 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 561304003492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561304003493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304003494 homodimer interface [polypeptide binding]; other site 561304003495 catalytic residue [active] 561304003496 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 561304003497 4Fe-4S binding domain; Region: Fer4; pfam00037 561304003498 2,4-Dienoyl-CoA Reductase 561304003500 FO synthase; Reviewed; Region: fbiC; PRK09234 561304003501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561304003502 FeS/SAM binding site; other site 561304003503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561304003504 FeS/SAM binding site; other site 561304003505 PE-family protein 561304003506 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 561304003507 transcriptional regulator 561304003508 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 561304003509 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 561304003510 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 561304003511 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 561304003512 G1 box; other site 561304003513 putative GEF interaction site [polypeptide binding]; other site 561304003514 GTP/Mg2+ binding site [chemical binding]; other site 561304003515 Switch I region; other site 561304003516 G2 box; other site 561304003517 G3 box; other site 561304003518 Switch II region; other site 561304003519 G4 box; other site 561304003520 G5 box; other site 561304003521 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 561304003522 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 561304003523 nitrate reductase [gamma] chain 561304003524 nitrate reductase [delta] chain 561304003525 nitrate reductase [beta] chain 561304003526 nitrate reductase [alpha] subunit 561304003527 MutT homologue 561304003528 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 561304003529 aromatic arch; other site 561304003530 DCoH dimer interaction site [polypeptide binding]; other site 561304003531 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 561304003532 DCoH tetramer interaction site [polypeptide binding]; other site 561304003533 substrate binding site [chemical binding]; other site 561304003534 mannosyltransferase; Provisional; Region: pimE; PRK13375 561304003536 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 561304003538 transcriptional regulator (GntR family) 561304003539 NAD-dependent deacetylase; Provisional; Region: PRK00481 561304003540 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 561304003541 NAD+ binding site [chemical binding]; other site 561304003542 substrate binding site [chemical binding]; other site 561304003543 Zn binding site [ion binding]; other site 561304003544 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 561304003545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561304003546 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 561304003547 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 561304003548 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 561304003549 dimer interface [polypeptide binding]; other site 561304003550 active site 561304003551 catalytic residue [active] 561304003552 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 561304003554 type I restriction/modification system DNA 561304003555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 561304003556 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 561304003557 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 561304003558 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 561304003559 folate binding site [chemical binding]; other site 561304003560 NADP+ binding site [chemical binding]; other site 561304003561 thymidylate synthase; Reviewed; Region: thyA; PRK01827 561304003562 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 561304003563 dimerization interface [polypeptide binding]; other site 561304003564 active site 561304003566 acyl-CoA dehydrogenase 561304003567 3-oxoacyl-[ACP] reductase 561304003568 acyl-CoA synthase 561304003569 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 561304003570 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 561304003571 dihydrodipicolinate reductase 561304003572 REP-family protein 561304003573 probable oxidoreductase 561304003575 transcriptional regulator (Lrp/AsnC family) 561304003576 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 561304003577 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 561304003578 hexamer interface [polypeptide binding]; other site 561304003579 ligand binding site [chemical binding]; other site 561304003580 putative active site [active] 561304003581 NAD(P) binding site [chemical binding]; other site 561304003582 PPE-family protein 561304003583 PE_PGRS-family protein 561304003585 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 561304003586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304003587 Walker A motif; other site 561304003588 ATP binding site [chemical binding]; other site 561304003589 Walker B motif; other site 561304003590 arginine finger; other site 561304003591 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 561304003592 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 561304003593 catalytic residues [active] 561304003594 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 561304003595 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 561304003596 active site 561304003597 catalytic residues [active] 561304003598 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 561304003599 EspG family; Region: ESX-1_EspG; pfam14011 561304003600 Probable ferredoxin 561304003601 Probable member of the cytochrome P450 561304003602 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 561304003603 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304003604 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 561304003605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304003606 Protein of unknown function (DUF690); Region: DUF690; pfam05108 561304003607 probable 4-[alpha]-glucanotransferase 561304003608 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 561304003609 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 561304003610 RNA binding site [nucleotide binding]; other site 561304003611 active site 561304003612 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 561304003613 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 561304003614 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 561304003615 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 561304003616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 561304003617 active site 561304003618 metal binding site [ion binding]; metal-binding site 561304003622 enoyl-CoA hydratase/isomerase superfamily 561304003623 prolyl-tRNA synthetase; Provisional; Region: PRK08661 561304003624 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 561304003625 dimer interface [polypeptide binding]; other site 561304003626 motif 1; other site 561304003627 active site 561304003628 motif 2; other site 561304003629 motif 3; other site 561304003630 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 561304003631 anticodon binding site; other site 561304003632 zinc-binding site [ion binding]; other site 561304003634 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 561304003635 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 561304003636 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 561304003637 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 561304003638 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 561304003639 G1 box; other site 561304003640 putative GEF interaction site [polypeptide binding]; other site 561304003641 GTP/Mg2+ binding site [chemical binding]; other site 561304003642 Switch I region; other site 561304003643 G2 box; other site 561304003644 G3 box; other site 561304003645 Switch II region; other site 561304003646 G4 box; other site 561304003647 G5 box; other site 561304003648 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 561304003649 Translation-initiation factor 2; Region: IF-2; pfam11987 561304003650 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 561304003651 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 561304003652 putative RNA binding cleft [nucleotide binding]; other site 561304003653 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 561304003654 NusA N-terminal domain; Region: NusA_N; pfam08529 561304003655 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 561304003656 RNA binding site [nucleotide binding]; other site 561304003657 homodimer interface [polypeptide binding]; other site 561304003658 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 561304003659 G-X-X-G motif; other site 561304003660 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 561304003661 G-X-X-G motif; other site 561304003663 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 561304003664 dinuclear metal binding motif [ion binding]; other site 561304003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561304003666 putative substrate translocation pore; other site 561304003667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561304003668 multifunctional enzyme, siroheme synthase 561304003669 cobyrinic acid a,c-diamide synthase 561304003670 cob(I)alamin adenosyltransferase 561304003671 possible magnesium-chelatase 561304003675 glutathione reductase homologue 561304003676 probable nickel transport protein 561304003677 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 561304003678 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 561304003679 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 561304003680 catalytic triad [active] 561304003681 proable glutamine synthase 561304003682 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 561304003683 active site 561304003684 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 561304003685 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 561304003686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561304003690 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 561304003691 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 561304003692 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 561304003693 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 561304003694 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 561304003695 active site 561304003696 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 561304003697 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 561304003698 putative substrate binding region [chemical binding]; other site 561304003699 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 561304003700 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 561304003701 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 561304003702 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 561304003703 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 561304003704 possible mercury resistance transport system 561304003705 hypothetical protein Mpt53 561304003708 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 561304003709 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 561304003710 ribosome recycling factor; Reviewed; Region: frr; PRK00083 561304003711 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 561304003712 hinge region; other site 561304003713 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 561304003714 putative nucleotide binding site [chemical binding]; other site 561304003715 uridine monophosphate binding site [chemical binding]; other site 561304003716 homohexameric interface [polypeptide binding]; other site 561304003717 two-component response regulator 561304003719 multidrug resistance protein 561304003720 possible regulatory protein 561304003721 amidase; Provisional; Region: PRK07869 561304003722 Amidase; Region: Amidase; pfam01425 561304003723 elongation factor Ts; Provisional; Region: tsf; PRK09377 561304003724 UBA/TS-N domain; Region: UBA; pfam00627 561304003725 Elongation factor TS; Region: EF_TS; pfam00889 561304003726 Elongation factor TS; Region: EF_TS; pfam00889 561304003727 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 561304003728 rRNA interaction site [nucleotide binding]; other site 561304003729 S8 interaction site; other site 561304003730 putative laminin-1 binding site; other site 561304003732 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 561304003733 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 561304003734 active site 561304003735 DNA binding site [nucleotide binding] 561304003736 Int/Topo IB signature motif; other site 561304003737 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 561304003738 ATP-grasp domain; Region: ATP-grasp_4; cl17255 561304003739 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 561304003741 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 561304003742 affects formate dehydrogenase-N 561304003743 molybdopterin-containing oxidoreductase 561304003744 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 561304003745 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 561304003746 RNA/DNA hybrid binding site [nucleotide binding]; other site 561304003747 active site 561304003748 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 561304003749 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 561304003750 Catalytic site [active] 561304003751 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 561304003752 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 561304003753 Slight similarity to beta-lactamase 561304003754 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 561304003755 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 561304003756 RimM N-terminal domain; Region: RimM; pfam01782 561304003757 PRC-barrel domain; Region: PRC; pfam05239 561304003758 hypothetical protein; Provisional; Region: PRK02821 561304003759 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 561304003760 G-X-X-G motif; other site 561304003761 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 561304003763 serine-threonine protein kinase 561304003765 signal recognition particle protein; Provisional; Region: PRK10867 561304003766 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 561304003767 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 561304003768 P loop; other site 561304003769 GTP binding site [chemical binding]; other site 561304003770 Signal peptide binding domain; Region: SRP_SPB; pfam02978 561304003771 heat shock protein 90; Provisional; Region: PRK05218 561304003772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304003773 ATP binding site [chemical binding]; other site 561304003774 Mg2+ binding site [ion binding]; other site 561304003775 G-X-G motif; other site 561304003776 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 561304003777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304003778 ATP binding site [chemical binding]; other site 561304003779 putative Mg++ binding site [ion binding]; other site 561304003780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 561304003781 ATP-binding site [chemical binding]; other site 561304003782 uridylyltransferase 561304003783 nitrogen regulatory protein 561304003784 ammonium transporter 561304003785 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 561304003786 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 561304003787 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 561304003788 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 561304003789 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 561304003790 Walker A/P-loop; other site 561304003791 ATP binding site [chemical binding]; other site 561304003792 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 561304003793 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 561304003794 ABC transporter signature motif; other site 561304003795 Walker B; other site 561304003796 D-loop; other site 561304003797 H-loop/switch region; other site 561304003798 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 561304003799 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 561304003800 metal binding triad; other site 561304003801 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 561304003802 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 561304003803 metal binding triad; other site 561304003804 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 561304003805 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 561304003806 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 561304003807 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 561304003808 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 561304003809 TAP-like protein; Region: Abhydrolase_4; pfam08386 561304003810 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 561304003811 TAP-like protein; Region: Abhydrolase_4; pfam08386 561304003813 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 561304003814 oligomerization interface [polypeptide binding]; other site 561304003815 active site 561304003816 metal binding site [ion binding]; metal-binding site 561304003818 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 561304003819 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 561304003820 RNA/DNA hybrid binding site [nucleotide binding]; other site 561304003821 active site 561304003822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304003823 catalytic core [active] 561304003824 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 561304003825 Putative zinc ribbon domain; Region: DUF164; pfam02591 561304003826 Uncharacterized conserved protein [Function unknown]; Region: COG0327 561304003827 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 561304003828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 561304003829 Uncharacterized conserved protein [Function unknown]; Region: COG0327 561304003830 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 561304003831 aminotransferase 561304003834 low molecular weight protein-tyrosine-phosphatase 561304003835 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 561304003836 cobinamide synthase 561304003839 member of AhpC/TSA family 561304003840 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 561304003842 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 561304003843 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 561304003844 dimer interface [polypeptide binding]; other site 561304003845 TPP-binding site [chemical binding]; other site 561304003846 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 561304003847 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 561304003848 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 561304003849 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 561304003850 acyl carrier protein; Provisional; Region: acpP; PRK00982 561304003851 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 561304003852 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 561304003853 dimer interface [polypeptide binding]; other site 561304003854 active site 561304003855 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 561304003856 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 561304003857 dimer interface [polypeptide binding]; other site 561304003858 active site 561304003859 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 561304003860 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 561304003861 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 561304003862 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 561304003863 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 561304003864 DNA binding site [nucleotide binding] 561304003865 catalytic residue [active] 561304003866 H2TH interface [polypeptide binding]; other site 561304003867 putative catalytic residues [active] 561304003868 turnover-facilitating residue; other site 561304003869 intercalation triad [nucleotide binding]; other site 561304003870 8OG recognition residue [nucleotide binding]; other site 561304003871 putative reading head residues; other site 561304003872 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 561304003873 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 561304003874 ribonuclease III; Reviewed; Region: rnc; PRK00102 561304003875 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 561304003876 dimerization interface [polypeptide binding]; other site 561304003877 active site 561304003878 metal binding site [ion binding]; metal-binding site 561304003879 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 561304003880 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 561304003881 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 561304003882 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 561304003883 integral membrane protein 561304003884 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 561304003885 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 561304003886 active site 561304003887 (T/H)XGH motif; other site 561304003888 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 561304003889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304003890 S-adenosylmethionine binding site [chemical binding]; other site 561304003891 pyruvate carboxylase 561304003892 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 561304003893 putative active site [active] 561304003894 redox center [active] 561304003895 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 561304003896 Thioredoxin; Region: Thioredoxin_4; cl17273 561304003897 probable lipase/esterase 561304003898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 561304003899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 561304003900 active site 561304003901 catalytic tetrad [active] 561304003903 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 561304003904 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 561304003905 generic binding surface II; other site 561304003906 ssDNA binding site; other site 561304003907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304003908 ATP binding site [chemical binding]; other site 561304003909 putative Mg++ binding site [ion binding]; other site 561304003910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304003911 nucleotide binding region [chemical binding]; other site 561304003912 ATP-binding site [chemical binding]; other site 561304003915 50S ribosomal protein L28 561304003916 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 561304003917 ligand binding site [chemical binding]; other site 561304003918 active site 561304003919 UGI interface [polypeptide binding]; other site 561304003920 catalytic site [active] 561304003921 thiamine monophosphate kinase; Provisional; Region: PRK05731 561304003922 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 561304003923 ATP binding site [chemical binding]; other site 561304003924 dimerization interface [polypeptide binding]; other site 561304003925 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 561304003926 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 561304003927 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 561304003928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 561304003929 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 561304003930 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 561304003931 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 561304003932 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 561304003933 polyphosphate kinase; Provisional; Region: PRK05443 561304003934 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 561304003935 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 561304003936 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 561304003937 putative domain interface [polypeptide binding]; other site 561304003938 putative active site [active] 561304003939 catalytic site [active] 561304003940 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 561304003941 putative active site [active] 561304003942 catalytic site [active] 561304003943 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 561304003944 active site 561304003945 Ap6A binding site [chemical binding]; other site 561304003946 nudix motif; other site 561304003947 metal binding site [ion binding]; metal-binding site 561304003948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304003949 catalytic core [active] 561304003950 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 561304003951 IHF - DNA interface [nucleotide binding]; other site 561304003952 IHF dimer interface [polypeptide binding]; other site 561304003953 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 561304003954 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 561304003955 substrate binding site [chemical binding]; other site 561304003956 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 561304003957 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 561304003958 substrate binding site [chemical binding]; other site 561304003959 ligand binding site [chemical binding]; other site 561304003960 transcriptional regulator (IclR family) 561304003962 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 561304003963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561304003964 active site 561304003965 HIGH motif; other site 561304003966 nucleotide binding site [chemical binding]; other site 561304003967 catalytic core domain of glutamyl-tRNA and glutaminyl-tRNA synthetase; Region: GlxRS_core; cd00418 561304003968 KMSKS motif; other site 561304003969 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 561304003970 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 561304003971 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 561304003972 probable fluoroquinolone efflux protein 561304003973 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 561304003974 tartrate dehydrogenase; Region: TTC; TIGR02089 561304003975 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 561304003976 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 561304003977 ligand binding site [chemical binding]; other site 561304003978 NAD binding site [chemical binding]; other site 561304003979 dimerization interface [polypeptide binding]; other site 561304003980 catalytic site [active] 561304003981 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 561304003982 putative L-serine binding site [chemical binding]; other site 561304003983 dehydrogenase 561304003984 ketol-acid reductoisomerase; Provisional; Region: PRK05479 561304003985 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 561304003986 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 561304003987 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 561304003988 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 561304003989 putative valine binding site [chemical binding]; other site 561304003990 dimer interface [polypeptide binding]; other site 561304003991 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 561304003992 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 561304003993 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 561304003994 PYR/PP interface [polypeptide binding]; other site 561304003995 dimer interface [polypeptide binding]; other site 561304003996 TPP binding site [chemical binding]; other site 561304003997 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 561304003998 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 561304003999 TPP-binding site [chemical binding]; other site 561304004000 dimer interface [polypeptide binding]; other site 561304004002 Predicted membrane protein [Function unknown]; Region: COG2259 561304004003 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 561304004004 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 561304004005 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 561304004006 GatB domain; Region: GatB_Yqey; pfam02637 561304004007 6-phosphofructokinase; Provisional; Region: PRK03202 561304004008 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 561304004009 active site 561304004010 ADP/pyrophosphate binding site [chemical binding]; other site 561304004011 dimerization interface [polypeptide binding]; other site 561304004012 allosteric effector site; other site 561304004013 fructose-1,6-bisphosphate binding site; other site 561304004014 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 561304004015 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 561304004016 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 561304004017 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 561304004018 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 561304004019 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 561304004020 nucleotide binding pocket [chemical binding]; other site 561304004021 K-X-D-G motif; other site 561304004022 catalytic site [active] 561304004023 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 561304004024 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 561304004025 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 561304004026 Dimer interface [polypeptide binding]; other site 561304004027 BRCT sequence motif; other site 561304004028 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 561304004029 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 561304004030 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 561304004031 Ligand Binding Site [chemical binding]; other site 561304004032 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 561304004033 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 561304004034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304004035 catalytic residue [active] 561304004036 some similarity to acyltransferase Q59601 561304004038 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 561304004039 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 561304004040 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 561304004041 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 561304004042 Ligand binding site [chemical binding]; other site 561304004043 Electron transfer flavoprotein domain; Region: ETF; pfam01012 561304004044 Methyltransferase domain; Region: Methyltransf_23; pfam13489 561304004045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304004046 S-adenosylmethionine binding site [chemical binding]; other site 561304004047 Uncharacterized conserved protein [Function unknown]; Region: COG1543 561304004048 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 561304004049 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 561304004050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561304004051 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 561304004052 unknown membrane protein 561304004054 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 561304004055 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 561304004056 trimer interface [polypeptide binding]; other site 561304004057 active site 561304004058 substrate binding site [chemical binding]; other site 561304004059 CoA binding site [chemical binding]; other site 561304004060 FOG: WD40-like repeat [Function unknown]; Region: COG1520 561304004061 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 561304004062 probable hypothetical protein 561304004064 Methyltransferase domain; Region: Methyltransf_31; pfam13847 561304004065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304004066 S-adenosylmethionine binding site [chemical binding]; other site 561304004067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304004068 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 561304004069 substrate binding site [chemical binding]; other site 561304004070 oxyanion hole (OAH) forming residues; other site 561304004071 trimer interface [polypeptide binding]; other site 561304004073 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 561304004074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304004075 Walker A/P-loop; other site 561304004076 ATP binding site [chemical binding]; other site 561304004077 ABC transporter signature motif; other site 561304004078 Walker B; other site 561304004079 D-loop; other site 561304004080 H-loop/switch region; other site 561304004081 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 561304004082 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 561304004083 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 561304004084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561304004085 motif II; other site 561304004086 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 561304004087 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 561304004088 D-pathway; other site 561304004089 Putative ubiquinol binding site [chemical binding]; other site 561304004090 Low-spin heme (heme b) binding site [chemical binding]; other site 561304004091 Putative water exit pathway; other site 561304004092 Binuclear center (heme o3/CuB) [ion binding]; other site 561304004093 K-pathway; other site 561304004094 Putative proton exit pathway; other site 561304004095 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 561304004096 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 561304004097 siderophore binding site; other site 561304004098 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 561304004099 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 561304004100 putative NAD(P) binding site [chemical binding]; other site 561304004101 putative substrate binding site [chemical binding]; other site 561304004102 catalytic Zn binding site [ion binding]; other site 561304004103 structural Zn binding site [ion binding]; other site 561304004104 dimer interface [polypeptide binding]; other site 561304004105 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 561304004106 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 561304004107 dimer interface [polypeptide binding]; other site 561304004108 putative radical transfer pathway; other site 561304004109 diiron center [ion binding]; other site 561304004110 tyrosyl radical; other site 561304004111 Probable monooxygenase 561304004112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304004113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304004114 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 561304004115 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 561304004116 Class I ribonucleotide reductase; Region: RNR_I; cd01679 561304004117 active site 561304004118 dimer interface [polypeptide binding]; other site 561304004119 catalytic residues [active] 561304004120 effector binding site; other site 561304004121 R2 peptide binding site; other site 561304004122 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 561304004123 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 561304004124 catalytic residues [active] 561304004126 transcriptional regulator 561304004127 DNA-damage-inducible protein 561304004128 short chain dehydrogenase; Provisional; Region: PRK07832 561304004129 classical (c) SDRs; Region: SDR_c; cd05233 561304004130 NAD(P) binding site [chemical binding]; other site 561304004131 active site 561304004132 transcriptional regulator 561304004133 possible lanosterol 14-alpha-demethylases 561304004134 PE-family protein 561304004135 transcriptional regulator (GntR family) 561304004136 acyl-CoA dehydrogenase 561304004137 short-chain alcohol dehydrogenase 561304004138 DNA ligase 561304004139 starvation-induced stress response protein 561304004141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 561304004142 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 561304004143 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 561304004144 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 561304004145 metal binding site [ion binding]; metal-binding site 561304004146 active site 561304004147 I-site; other site 561304004148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 561304004149 hypothetical protein; Provisional; Region: PRK07877 561304004150 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 561304004151 ATP binding site [chemical binding]; other site 561304004152 substrate interface [chemical binding]; other site 561304004153 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 561304004154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 561304004155 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 561304004156 cyclase homology domain; Region: CHD; cd07302 561304004157 nucleotidyl binding site; other site 561304004158 metal binding site [ion binding]; metal-binding site 561304004159 dimer interface [polypeptide binding]; other site 561304004160 Predicted ATPase [General function prediction only]; Region: COG3903 561304004161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 561304004162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 561304004163 DNA binding residues [nucleotide binding] 561304004164 dimerization interface [polypeptide binding]; other site 561304004165 PPE-family protein 561304004166 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 561304004167 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 561304004168 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 561304004169 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 561304004170 transcriptional regulator 561304004171 probable oxidoreductase 561304004172 phosphoglucomutase 561304004173 integrase 561304004174 possible transport protein 561304004175 transport protein 561304004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304004180 dimer interface [polypeptide binding]; other site 561304004181 conserved gate region; other site 561304004182 putative PBP binding loops; other site 561304004183 ABC-ATPase subunit interface; other site 561304004184 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561304004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304004186 dimer interface [polypeptide binding]; other site 561304004187 conserved gate region; other site 561304004188 putative PBP binding loops; other site 561304004189 ABC-ATPase subunit interface; other site 561304004190 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561304004191 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 561304004193 arginine/ornithine transporter 561304004194 ornithine aminotransferase 561304004195 ornithine aminotransferase 561304004197 transcriptional regulator (Lrp/AsnC family) 561304004198 glycerol-3-phosphate dehydrogenase 561304004199 transcriptional regulator 561304004202 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 561304004203 Beta-lactamase; Region: Beta-lactamase; pfam00144 561304004204 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 561304004205 Methyltransferase domain; Region: Methyltransf_31; pfam13847 561304004206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304004207 S-adenosylmethionine binding site [chemical binding]; other site 561304004208 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 561304004209 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 561304004210 NAD binding site [chemical binding]; other site 561304004211 catalytic Zn binding site [ion binding]; other site 561304004212 substrate binding site [chemical binding]; other site 561304004213 structural Zn binding site [ion binding]; other site 561304004215 apolipoprotein N-acyltransferase-a 561304004216 Probable cytochrome P-450 561304004219 YacP-like NYN domain; Region: NYN_YacP; cl01491 561304004220 probable Na+/H+ exchanger 561304004221 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 561304004222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561304004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304004224 homodimer interface [polypeptide binding]; other site 561304004225 catalytic residue [active] 561304004226 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 561304004227 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 561304004228 putative dimer interface [polypeptide binding]; other site 561304004229 probable esterase 561304004230 membrane ATPase/protein kinase; Provisional; Region: PRK09435 561304004231 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 561304004232 Walker A; other site 561304004233 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 561304004234 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 561304004235 active site 561304004236 substrate binding site [chemical binding]; other site 561304004237 coenzyme B12 binding site [chemical binding]; other site 561304004238 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 561304004239 B12 binding site [chemical binding]; other site 561304004240 cobalt ligand [ion binding]; other site 561304004241 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 561304004242 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 561304004243 heterodimer interface [polypeptide binding]; other site 561304004244 substrate interaction site [chemical binding]; other site 561304004245 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 561304004246 probable membrane protein 561304004247 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 561304004248 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 561304004249 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 561304004250 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 561304004251 ferrochelatase; Reviewed; Region: hemH; PRK00035 561304004252 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 561304004253 C-terminal domain interface [polypeptide binding]; other site 561304004254 active site 561304004255 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 561304004256 active site 561304004257 N-terminal domain interface [polypeptide binding]; other site 561304004258 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 561304004259 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 561304004260 NAD binding site [chemical binding]; other site 561304004261 homotetramer interface [polypeptide binding]; other site 561304004262 homodimer interface [polypeptide binding]; other site 561304004263 substrate binding site [chemical binding]; other site 561304004264 active site 561304004265 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 561304004266 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 561304004267 NAD(P) binding site [chemical binding]; other site 561304004268 homotetramer interface [polypeptide binding]; other site 561304004269 homodimer interface [polypeptide binding]; other site 561304004270 active site 561304004271 hypothetical protein; Provisional; Region: PRK13685 561304004272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 561304004273 metal ion-dependent adhesion site (MIDAS); other site 561304004274 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 561304004275 Protein of unknown function DUF58; Region: DUF58; pfam01882 561304004276 MoxR-like ATPases [General function prediction only]; Region: COG0714 561304004277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304004278 Walker A motif; other site 561304004279 ATP binding site [chemical binding]; other site 561304004280 Walker B motif; other site 561304004281 arginine finger; other site 561304004282 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 561304004283 NlpC/P60 family; Region: NLPC_P60; pfam00877 561304004284 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 561304004285 NlpC/P60 family; Region: NLPC_P60; pfam00877 561304004286 aconitate hydratase; Validated; Region: PRK09277 561304004287 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 561304004288 substrate binding site [chemical binding]; other site 561304004289 ligand binding site [chemical binding]; other site 561304004290 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 561304004291 substrate binding site [chemical binding]; other site 561304004292 transcriptional regulator (TetR/AcrR family) 561304004293 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 561304004294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304004295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304004296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561304004297 enoyl-CoA hydratase/isomerase superfamily 561304004298 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561304004299 catalytic residues [active] 561304004300 cation-transporting ATPase 561304004301 similar at C-term to adenylate cyclases 561304004302 probable cutinase 561304004303 transposase 561304004305 Unsure04. Len: 304 bases. Part of a repeat_region (Leprep5) which has not been sequenced, correspond to position 2209189..2209492 in Mycobacterium leprae strain TN genome. 561304004307 cobinamide kinase 561304004308 cobyric acid synthase 561304004309 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304004310 PPE family; Region: PPE; pfam00823 561304004312 aminotransferase 561304004313 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 561304004314 active site 561304004315 adenylate kinase; Reviewed; Region: adk; PRK00279 561304004316 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 561304004317 AMP-binding site [chemical binding]; other site 561304004318 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 561304004319 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 561304004320 SecY translocase; Region: SecY; pfam00344 561304004322 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 561304004323 primary dimer interface [polypeptide binding]; other site 561304004324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561304004325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 561304004326 Coenzyme A binding pocket [chemical binding]; other site 561304004327 xylulose kinase 561304004328 similar to D-3-phosphoglycerate dehydrogenases 561304004329 L-fuculose phosphate aldolase 561304004330 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 561304004331 tandem repeat interface [polypeptide binding]; other site 561304004332 oligomer interface [polypeptide binding]; other site 561304004333 active site residues [active] 561304004334 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 561304004335 tandem repeat interface [polypeptide binding]; other site 561304004336 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 561304004337 oligomer interface [polypeptide binding]; other site 561304004338 active site residues [active] 561304004339 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 561304004340 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 561304004341 23S rRNA binding site [nucleotide binding]; other site 561304004342 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 561304004343 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 561304004344 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 561304004345 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 561304004346 5S rRNA interface [nucleotide binding]; other site 561304004347 L27 interface [polypeptide binding]; other site 561304004348 23S rRNA interface [nucleotide binding]; other site 561304004349 L5 interface [polypeptide binding]; other site 561304004350 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 561304004351 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 561304004352 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 561304004353 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 561304004354 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 561304004355 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 561304004356 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 561304004357 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 561304004358 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 561304004359 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 561304004360 RNA binding site [nucleotide binding]; other site 561304004361 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 561304004364 integral membrane protein 561304004365 arylsulfatase 561304004366 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 561304004367 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 561304004368 putative translocon interaction site; other site 561304004369 23S rRNA interface [nucleotide binding]; other site 561304004370 signal recognition particle (SRP54) interaction site; other site 561304004371 L23 interface [polypeptide binding]; other site 561304004372 trigger factor interaction site; other site 561304004373 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 561304004374 23S rRNA interface [nucleotide binding]; other site 561304004375 5S rRNA interface [nucleotide binding]; other site 561304004376 putative antibiotic binding site [chemical binding]; other site 561304004377 L25 interface [polypeptide binding]; other site 561304004378 L27 interface [polypeptide binding]; other site 561304004379 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 561304004380 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 561304004381 G-X-X-G motif; other site 561304004382 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 561304004383 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 561304004384 putative translocon binding site; other site 561304004385 protein-rRNA interface [nucleotide binding]; other site 561304004386 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 561304004387 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 561304004388 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 561304004389 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 561304004390 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 561304004391 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 561304004392 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 561304004393 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 561304004394 PE-family protein 561304004395 gmc-type oxidoreductase 561304004396 glycosyltransferase 561304004398 L-lactate dehydrogenase (cytochrome) 561304004399 coenzyme pqq synthesis protein E 561304004401 transcriptional regulator (TetR/AcrR family) 561304004403 oxidoreductase 561304004404 dehydrogenase, SDR family 561304004405 potential membrane protein 561304004406 elongation factor Tu; Reviewed; Region: PRK00049 561304004407 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 561304004408 G1 box; other site 561304004409 GEF interaction site [polypeptide binding]; other site 561304004410 GTP/Mg2+ binding site [chemical binding]; other site 561304004411 Switch I region; other site 561304004412 G2 box; other site 561304004413 G3 box; other site 561304004414 Switch II region; other site 561304004415 G4 box; other site 561304004416 G5 box; other site 561304004417 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 561304004418 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 561304004419 Antibiotic Binding Site [chemical binding]; other site 561304004420 elongation factor G; Reviewed; Region: PRK00007 561304004421 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 561304004422 G1 box; other site 561304004423 putative GEF interaction site [polypeptide binding]; other site 561304004424 GTP/Mg2+ binding site [chemical binding]; other site 561304004425 Switch I region; other site 561304004426 G2 box; other site 561304004427 G3 box; other site 561304004428 Switch II region; other site 561304004429 G4 box; other site 561304004430 G5 box; other site 561304004431 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 561304004432 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 561304004433 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 561304004434 30S ribosomal protein S7; Validated; Region: PRK05302 561304004435 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 561304004436 S17 interaction site [polypeptide binding]; other site 561304004437 S8 interaction site; other site 561304004438 16S rRNA interaction site [nucleotide binding]; other site 561304004439 streptomycin interaction site [chemical binding]; other site 561304004440 23S rRNA interaction site [nucleotide binding]; other site 561304004441 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 561304004442 glycosyltransferase 561304004443 transcriptional regulator (TetR/AcrR family) 561304004444 possible membrane protein 561304004445 possible membrane protein 561304004446 enoyl-CoA hydratase/isomerase superfamily 561304004448 enoyl-CoA hydratase/isomerase superfamily 561304004449 acyl-CoA dehydrogenase (aka aidB) 561304004450 endonuclease IV; Provisional; Region: PRK01060 561304004451 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 561304004452 AP (apurinic/apyrimidinic) site pocket; other site 561304004453 DNA interaction; other site 561304004454 Metal-binding active site; metal-binding site 561304004455 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 561304004456 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 561304004457 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 561304004458 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 561304004459 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 561304004460 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 561304004461 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 561304004462 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 561304004463 G-loop; other site 561304004464 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 561304004465 DNA binding site [nucleotide binding] 561304004466 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 561304004467 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 561304004468 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 561304004469 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 561304004470 RPB10 interaction site [polypeptide binding]; other site 561304004471 RPB1 interaction site [polypeptide binding]; other site 561304004472 RPB11 interaction site [polypeptide binding]; other site 561304004473 RPB3 interaction site [polypeptide binding]; other site 561304004474 RPB12 interaction site [polypeptide binding]; other site 561304004475 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 561304004476 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 561304004477 Walker A/P-loop; other site 561304004478 ATP binding site [chemical binding]; other site 561304004479 Q-loop/lid; other site 561304004480 ABC transporter signature motif; other site 561304004481 Walker B; other site 561304004482 D-loop; other site 561304004483 H-loop/switch region; other site 561304004484 dioxygenase 561304004485 transcriptional regulator 561304004486 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 561304004487 core dimer interface [polypeptide binding]; other site 561304004488 peripheral dimer interface [polypeptide binding]; other site 561304004489 L10 interface [polypeptide binding]; other site 561304004490 L11 interface [polypeptide binding]; other site 561304004491 putative EF-Tu interaction site [polypeptide binding]; other site 561304004492 putative EF-G interaction site [polypeptide binding]; other site 561304004493 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 561304004494 23S rRNA interface [nucleotide binding]; other site 561304004495 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 561304004496 transcriptional regulator (ROK family) 561304004497 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 561304004498 ABC1 family; Region: ABC1; cl17513 561304004499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 561304004500 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 561304004501 Serine hydrolase (FSH1); Region: FSH1; pfam03959 561304004502 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 561304004503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304004504 S-adenosylmethionine binding site [chemical binding]; other site 561304004505 methyl mycolic acid synthase 2 561304004506 methyl mycolic acid synthase 3 561304004507 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 561304004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304004509 S-adenosylmethionine binding site [chemical binding]; other site 561304004510 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 561304004511 mRNA/rRNA interface [nucleotide binding]; other site 561304004512 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 561304004513 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 561304004514 23S rRNA interface [nucleotide binding]; other site 561304004515 L7/L12 interface [polypeptide binding]; other site 561304004516 putative thiostrepton binding site; other site 561304004517 L25 interface [polypeptide binding]; other site 561304004518 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 561304004519 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 561304004520 putative homodimer interface [polypeptide binding]; other site 561304004521 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 561304004522 heterodimer interface [polypeptide binding]; other site 561304004523 homodimer interface [polypeptide binding]; other site 561304004524 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 561304004525 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 561304004526 active site 561304004527 catalytic site [active] 561304004528 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 561304004529 active site 561304004530 catalytic site [active] 561304004531 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 561304004532 active site 561304004533 catalytic site [active] 561304004534 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 561304004535 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 561304004536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 561304004537 enoyl-CoA hydratase/isomerase superfamily 561304004538 equivalent to MKU20446_1 MK35 561304004539 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 561304004542 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 561304004543 active site clefts [active] 561304004544 zinc binding site [ion binding]; other site 561304004545 dimer interface [polypeptide binding]; other site 561304004546 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 561304004547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 561304004548 minor groove reading motif; other site 561304004549 helix-hairpin-helix signature motif; other site 561304004550 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 561304004551 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 561304004552 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 561304004553 catalytic site [active] 561304004554 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 561304004555 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 561304004556 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 561304004558 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 561304004559 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 561304004560 E-class dimer interface [polypeptide binding]; other site 561304004561 P-class dimer interface [polypeptide binding]; other site 561304004562 active site 561304004563 Cu2+ binding site [ion binding]; other site 561304004564 Zn2+ binding site [ion binding]; other site 561304004565 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 561304004566 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 561304004567 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 561304004568 active site 561304004569 catalytic residues [active] 561304004570 metal binding site [ion binding]; metal-binding site 561304004572 exodeoxyribonuclease III 561304004573 cation-transporting 561304004575 PPE-family protein 561304004576 GTP-binding protein YchF; Reviewed; Region: PRK09601 561304004577 YchF GTPase; Region: YchF; cd01900 561304004578 G1 box; other site 561304004579 GTP/Mg2+ binding site [chemical binding]; other site 561304004580 Switch I region; other site 561304004581 G2 box; other site 561304004582 Switch II region; other site 561304004583 G3 box; other site 561304004584 G4 box; other site 561304004585 G5 box; other site 561304004586 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 561304004587 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 561304004588 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 561304004589 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 561304004590 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 561304004591 generic binding surface II; other site 561304004592 generic binding surface I; other site 561304004593 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 561304004594 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 561304004595 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 561304004596 putative NAD(P) binding site [chemical binding]; other site 561304004597 active site 561304004598 putative substrate binding site [chemical binding]; other site 561304004600 possible IS1081 transposase 561304004601 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 561304004602 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 561304004603 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 561304004604 putative active site [active] 561304004605 fumarate hydratase; Reviewed; Region: fumC; PRK00485 561304004606 Class II fumarases; Region: Fumarase_classII; cd01362 561304004607 active site 561304004608 tetramer interface [polypeptide binding]; other site 561304004609 probable transmembrane protein 561304004610 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 561304004611 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 561304004612 NodB motif; other site 561304004613 active site 561304004614 catalytic site [active] 561304004615 metal binding site [ion binding]; metal-binding site 561304004616 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 561304004617 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 561304004618 putative active site [active] 561304004619 PhoH-like protein; Region: PhoH; pfam02562 561304004620 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 561304004621 dinuclear metal binding motif [ion binding]; other site 561304004622 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 561304004623 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 561304004624 dimer interface [polypeptide binding]; other site 561304004625 active site 561304004626 glycine-pyridoxal phosphate binding site [chemical binding]; other site 561304004627 folate binding site [chemical binding]; other site 561304004628 pantothenate kinase; Provisional; Region: PRK05439 561304004629 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 561304004630 ATP-binding site [chemical binding]; other site 561304004631 CoA-binding site [chemical binding]; other site 561304004632 Mg2+-binding site [ion binding]; other site 561304004633 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 561304004634 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 561304004635 active site 561304004636 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 561304004637 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 561304004638 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 561304004639 alphaNTD - beta interaction site [polypeptide binding]; other site 561304004640 alphaNTD homodimer interface [polypeptide binding]; other site 561304004641 alphaNTD - beta' interaction site [polypeptide binding]; other site 561304004642 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 561304004643 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 561304004644 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 561304004645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561304004646 RNA binding surface [nucleotide binding]; other site 561304004647 30S ribosomal protein S11; Validated; Region: PRK05309 561304004648 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 561304004649 30S ribosomal protein S13; Region: bact_S13; TIGR03631 561304004650 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 561304004651 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 561304004652 rRNA binding site [nucleotide binding]; other site 561304004653 predicted 30S ribosome binding site; other site 561304004654 probable neuraminidase 561304004655 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 561304004656 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 561304004657 NAD binding site [chemical binding]; other site 561304004658 substrate binding site [chemical binding]; other site 561304004659 homodimer interface [polypeptide binding]; other site 561304004660 active site 561304004661 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 561304004662 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 561304004663 PPE family protein 561304004664 PE family protein 561304004668 glycosyl hydrolase 561304004669 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 561304004670 probable oxidoreductase 561304004671 membrane protein 561304004672 probable epoxide hydrolase 561304004673 acyl-CoA synthase 561304004675 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 561304004676 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 561304004677 putative hydrophobic ligand binding site [chemical binding]; other site 561304004678 protein interface [polypeptide binding]; other site 561304004679 gate; other site 561304004680 possible oxidoreductase 561304004681 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 561304004682 tetramer interface [polypeptide binding]; other site 561304004683 active site 561304004684 Mg2+/Mn2+ binding site [ion binding]; other site 561304004685 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 561304004686 ECF subfamily sigma subunit 561304004687 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 561304004688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561304004689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 561304004690 Predicted integral membrane protein [Function unknown]; Region: COG5660 561304004691 Putative zinc-finger; Region: zf-HC2; pfam13490 561304004692 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 561304004693 PPE family; Region: PPE; pfam00823 561304004694 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 561304004695 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 561304004696 FcoT-like thioesterase domain; Region: FcoT; pfam10862 561304004697 acyl-CoA synthetase; Validated; Region: PRK05857 561304004698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304004699 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 561304004700 acyl-activating enzyme (AAE) consensus motif; other site 561304004701 acyl-activating enzyme (AAE) consensus motif; other site 561304004702 AMP binding site [chemical binding]; other site 561304004703 active site 561304004704 CoA binding site [chemical binding]; other site 561304004705 Phosphopantetheine attachment site; Region: PP-binding; cl09936 561304004706 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 561304004707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304004708 acyl-activating enzyme (AAE) consensus motif; other site 561304004709 AMP binding site [chemical binding]; other site 561304004710 active site 561304004711 CoA binding site [chemical binding]; other site 561304004712 thioester reductase domain; Region: Thioester-redct; TIGR01746 561304004713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304004714 NAD(P) binding site [chemical binding]; other site 561304004715 active site 561304004716 Predicted membrane protein [Function unknown]; Region: COG3336 561304004717 carboxyvinyl-carboxyphosphonate phosphorylmutase 561304004718 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 561304004719 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 561304004720 metal-binding site [ion binding] 561304004721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561304004722 Soluble P-type ATPase [General function prediction only]; Region: COG4087 561304004724 3-hydroxyacyl-CoA dehydrogenase 561304004725 probable ketoacyl reductase 561304004726 hydrolase 561304004730 ferric uptake regulatory protein 561304004731 catalase-peroxidase 561304004732 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 561304004733 Predicted membrane protein [Function unknown]; Region: COG1950 561304004734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 561304004735 probable sialic acid transporter 561304004736 competence damage-inducible protein A; Provisional; Region: PRK00549 561304004737 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 561304004738 putative MPT binding site; other site 561304004739 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 561304004740 probable esterase 561304004741 lipoprotein 561304004744 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 561304004745 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 561304004746 some similarity to dioxygenases 561304004747 cytochrome p450 561304004748 alcohol dehydrogenase 561304004751 Predicted esterase [General function prediction only]; Region: COG0627 561304004753 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 561304004754 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 561304004755 hydrophobic ligand binding site; other site 561304004756 lipoprotein 561304004757 Similar to 6-deoxyerythronolide beta hydroxylase 561304004758 methyltransferase 561304004760 probable glutamine synthase 561304004761 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 561304004762 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 561304004763 heme binding site [chemical binding]; other site 561304004764 ferroxidase pore; other site 561304004765 ferroxidase diiron center [ion binding]; other site 561304004768 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 561304004769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 561304004770 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 561304004771 dimerization interface [polypeptide binding]; other site 561304004772 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 561304004773 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 561304004774 dimer interface [polypeptide binding]; other site 561304004775 decamer (pentamer of dimers) interface [polypeptide binding]; other site 561304004776 catalytic triad [active] 561304004777 peroxidatic and resolving cysteines [active] 561304004778 member of AhpC/TSA family 561304004779 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 561304004780 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 561304004781 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 561304004782 active site 561304004783 substrate binding site [chemical binding]; other site 561304004784 FMN binding site [chemical binding]; other site 561304004785 putative catalytic residues [active] 561304004787 Domain of unknown function (DUF385); Region: DUF385; cl04387 561304004789 probable reductase (like rhodocoxin reductase) 561304004791 probable membrane protein 561304004792 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 561304004793 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 561304004794 putative NAD(P) binding site [chemical binding]; other site 561304004795 putative substrate binding site [chemical binding]; other site 561304004796 catalytic Zn binding site [ion binding]; other site 561304004797 structural Zn binding site [ion binding]; other site 561304004798 Predicted membrane protein [Function unknown]; Region: COG2261 561304004799 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 561304004800 molybdate uptake ABC-transporter 561304004801 transport system permease, molybdate uptake 561304004802 molybdate binding protein 561304004803 classical (c) SDRs; Region: SDR_c; cd05233 561304004804 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 561304004805 NAD(P) binding site [chemical binding]; other site 561304004806 active site 561304004807 probable monooxygenase 561304004808 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 561304004809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561304004810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561304004812 Predicted transcriptional regulator [Transcription]; Region: COG3682 561304004813 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 561304004814 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 561304004815 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 561304004816 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 561304004817 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 561304004818 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 561304004819 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 561304004820 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 561304004821 active site 561304004822 possible membrane protein 561304004823 possible membrane protein 561304004824 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 561304004825 active site 561304004826 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 561304004827 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 561304004828 metal ion-dependent adhesion site (MIDAS); other site 561304004829 similar to 1,3,4,6-tetrachloro-1,4-cyclohexadien 561304004830 glycine dehydrogenase; Provisional; Region: PRK05367 561304004831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 561304004832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304004833 catalytic residue [active] 561304004834 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 561304004835 tetramer interface [polypeptide binding]; other site 561304004836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304004837 catalytic residue [active] 561304004838 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 561304004839 DNA binding residues [nucleotide binding] 561304004840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 561304004841 putative dimer interface [polypeptide binding]; other site 561304004842 Bifunctional nuclease; Region: DNase-RNase; pfam02577 561304004843 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 561304004844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 561304004845 DNA binding residues [nucleotide binding] 561304004846 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 561304004847 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 561304004848 phosphopeptide binding site; other site 561304004849 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 561304004850 lipoyl attachment site [posttranslational modification]; other site 561304004852 small basic protein similar SBP_BACSU 561304004854 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 561304004855 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 561304004856 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 561304004857 hypothetical protein; Provisional; Region: PRK05858 561304004858 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 561304004859 PYR/PP interface [polypeptide binding]; other site 561304004860 dimer interface [polypeptide binding]; other site 561304004861 TPP binding site [chemical binding]; other site 561304004862 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 561304004863 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 561304004864 TPP-binding site; other site 561304004865 dimer interface [polypeptide binding]; other site 561304004866 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 561304004867 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 561304004868 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 561304004871 Unsure05. Len: 114 bases. Part of a repeat_region (Leprep7) which has not been sequenced, correspond to position 2480491..2480604 in Mycobacterium leprae strain TN genome. 561304004873 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 561304004874 Cytochrome P450; Region: p450; cl12078 561304004875 probable dehydrase 561304004877 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 561304004878 ATP binding site [chemical binding]; other site 561304004879 substrate binding site [chemical binding]; other site 561304004881 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 561304004882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304004883 dimer interface [polypeptide binding]; other site 561304004884 conserved gate region; other site 561304004885 putative PBP binding loops; other site 561304004886 ABC-ATPase subunit interface; other site 561304004887 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 561304004888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561304004889 dimer interface [polypeptide binding]; other site 561304004890 conserved gate region; other site 561304004891 putative PBP binding loops; other site 561304004892 ABC-ATPase subunit interface; other site 561304004893 PBP superfamily domain; Region: PBP_like_2; cl17296 561304004894 short-chain alcohol dehydrogenase 561304004896 manganese transport protein MntH; Reviewed; Region: PRK00701 561304004897 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 561304004898 ribonucleotide reductase, class II 561304004901 esterase 561304004908 lipid transfer protein 561304004909 probable dioxygenase 561304004911 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 561304004912 hydrophobic ligand binding site; other site 561304004913 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 561304004914 probable cation transport ATPase 561304004915 probable penicillin binding protein 561304004916 probable membrane protein 561304004917 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 561304004918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304004919 substrate binding site [chemical binding]; other site 561304004920 oxyanion hole (OAH) forming residues; other site 561304004921 trimer interface [polypeptide binding]; other site 561304004922 acetyl/propionyl CoA carboxylase [beta] subunit 561304004924 dehydrogenase 561304004925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561304004926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561304004927 active site 561304004928 phosphorylation site [posttranslational modification] 561304004929 intermolecular recognition site; other site 561304004930 dimerization interface [polypeptide binding]; other site 561304004931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561304004932 DNA binding site [nucleotide binding] 561304004933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561304004934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 561304004935 dimerization interface [polypeptide binding]; other site 561304004936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561304004937 dimer interface [polypeptide binding]; other site 561304004938 phosphorylation site [posttranslational modification] 561304004939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304004940 Mg2+ binding site [ion binding]; other site 561304004941 G-X-G motif; other site 561304004943 member of OmpA family 561304004944 possible oxidoreductase 561304004945 PPE-family protein 561304004946 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 561304004947 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 561304004948 dimer interface [polypeptide binding]; other site 561304004949 active site 561304004950 citrylCoA binding site [chemical binding]; other site 561304004951 NADH binding [chemical binding]; other site 561304004952 cationic pore residues; other site 561304004953 oxalacetate/citrate binding site [chemical binding]; other site 561304004954 coenzyme A binding site [chemical binding]; other site 561304004955 catalytic triad [active] 561304004956 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 561304004957 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 561304004958 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 561304004959 citrate synthase 2 561304004961 Ferredoxin [Energy production and conversion]; Region: COG1146 561304004962 4Fe-4S binding domain; Region: Fer4; pfam00037 561304004963 ferredoxin-NADP+ reductase; Region: PLN02852 561304004964 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 561304004965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 561304004966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304004967 catalytic residue [active] 561304004968 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 561304004969 unknown hydrophobic protein 561304004970 possible rRNA methyltransferase 561304004971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 561304004972 MarR family; Region: MarR; pfam01047 561304004973 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 561304004974 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 561304004975 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 561304004976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 561304004977 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 561304004978 transport of D-alanine, D-serine and glycine 561304004979 acyl-CoA dehydrogenase 561304004980 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 561304004981 DNA-binding site [nucleotide binding]; DNA binding site 561304004982 RNA-binding motif; other site 561304004983 unknown hydrophobic protein 561304004984 molybdenum cofactor biosynthesis, protein A 561304004985 molybdopterin converting factor subunit 1 561304004986 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 561304004987 molybdopterin-converting factor subunit 2 561304004988 molybdopterin biosynthesis 561304004989 molybdenum cofactor biosynthesis, protein C 561304004990 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 561304004991 WYL domain; Region: WYL; pfam13280 561304004992 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 561304004993 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 561304004994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561304004995 ATP binding site [chemical binding]; other site 561304004996 putative Mg++ binding site [ion binding]; other site 561304004997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561304004998 nucleotide binding region [chemical binding]; other site 561304004999 ATP-binding site [chemical binding]; other site 561304005000 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 561304005001 possible cytochrome P450 561304005002 probable oxidoreductase 561304005003 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 561304005004 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304005005 substrate binding site [chemical binding]; other site 561304005006 oxyanion hole (OAH) forming residues; other site 561304005007 trimer interface [polypeptide binding]; other site 561304005008 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 561304005009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 561304005010 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 561304005011 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 561304005012 dimer interface [polypeptide binding]; other site 561304005013 active site 561304005014 possible aminotransferase 561304005016 fatty acyl-CoA racemase 561304005018 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 561304005019 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 561304005020 dimer interface [polypeptide binding]; other site 561304005021 PYR/PP interface [polypeptide binding]; other site 561304005022 TPP binding site [chemical binding]; other site 561304005023 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 561304005024 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 561304005025 TPP-binding site [chemical binding]; other site 561304005026 dimer interface [polypeptide binding]; other site 561304005027 acyl-CoA synthase 561304005028 acyl-CoA synthase 561304005029 similar to several L-ascorbate oxidases 561304005030 possible oxidoredutase 561304005031 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 561304005032 active site 561304005033 catalytic motif [active] 561304005034 Zn binding site [ion binding]; other site 561304005035 possible sugar transporter 561304005036 uridine phosphorylase; Region: euk_UDPppase; TIGR01719 561304005037 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 561304005038 transcriptional regulator 561304005041 transcriptional regulator (ArsR family) 561304005044 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 561304005045 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 561304005046 homodimer interface [polypeptide binding]; other site 561304005047 putative substrate binding pocket [chemical binding]; other site 561304005048 diiron center [ion binding]; other site 561304005049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 561304005050 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 561304005051 FMN binding site [chemical binding]; other site 561304005052 active site 561304005053 catalytic residues [active] 561304005054 substrate binding site [chemical binding]; other site 561304005056 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 561304005057 PhoU domain; Region: PhoU; pfam01895 561304005058 PhoU domain; Region: PhoU; pfam01895 561304005059 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 561304005060 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 561304005061 Walker A/P-loop; other site 561304005062 ATP binding site [chemical binding]; other site 561304005063 Q-loop/lid; other site 561304005064 ABC transporter signature motif; other site 561304005065 Walker B; other site 561304005066 D-loop; other site 561304005067 H-loop/switch region; other site 561304005068 PstA component of phosphate uptake 561304005069 membrane-bound component of phosphate transport 561304005070 PBP superfamily domain; Region: PBP_like_2; cl17296 561304005071 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 561304005072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561304005073 Coenzyme A binding pocket [chemical binding]; other site 561304005074 two-component response regulator 561304005075 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 561304005076 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561304005077 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561304005078 catalytic residues [active] 561304005079 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 561304005080 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 561304005081 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 561304005082 active site residue [active] 561304005083 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 561304005084 active site residue [active] 561304005085 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 561304005086 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 561304005087 heme-binding site [chemical binding]; other site 561304005088 aminodeoxychorismate lyase 561304005089 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 561304005090 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 561304005091 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 561304005092 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 561304005093 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 561304005094 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 561304005095 dimerization interface [polypeptide binding]; other site 561304005096 putative ATP binding site [chemical binding]; other site 561304005097 amidophosphoribosyltransferase; Provisional; Region: PRK07847 561304005098 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 561304005099 active site 561304005100 tetramer interface [polypeptide binding]; other site 561304005101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561304005102 active site 561304005103 cell invasion protein 561304005104 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 561304005105 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 561304005106 active site 561304005107 metal binding site [ion binding]; metal-binding site 561304005108 hexamer interface [polypeptide binding]; other site 561304005109 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 561304005110 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 561304005111 dimerization interface [polypeptide binding]; other site 561304005112 ATP binding site [chemical binding]; other site 561304005113 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 561304005114 dimerization interface [polypeptide binding]; other site 561304005115 ATP binding site [chemical binding]; other site 561304005116 acetyltransferase 561304005117 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 561304005118 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 561304005119 active site 561304005120 metal binding site [ion binding]; metal-binding site 561304005122 probable penicillin binding protein 561304005123 dihydrolipoamide dehydrogenase 561304005126 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 561304005127 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 561304005128 putative active site [active] 561304005129 catalytic triad [active] 561304005130 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 561304005133 dehydrogenases 561304005135 multidrug resistance protein 561304005136 transcriptional regulator, tetr family 561304005137 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 561304005138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 561304005139 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 561304005140 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 561304005141 ATP binding site [chemical binding]; other site 561304005142 active site 561304005143 substrate binding site [chemical binding]; other site 561304005144 similar linalool 8-monooxygenase, cytochrome p-450 561304005145 adenylosuccinate lyase; Region: purB; TIGR00928 561304005146 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 561304005147 tetramer interface [polypeptide binding]; other site 561304005151 [gamma]-glutamyl transpeptidase 561304005152 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 561304005153 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 561304005154 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 561304005155 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 561304005156 REP13E12-family protein 561304005157 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 561304005158 nucleotide binding site/active site [active] 561304005159 HIT family signature motif; other site 561304005160 catalytic residue [active] 561304005161 sensor histidine kinase 561304005162 two-component response regulator 561304005164 PE_PGRS-family protein 561304005165 PPE-family protein 561304005166 sarcosine oxidase 561304005167 unknown membrane protein 561304005168 Transcriptional regulator [Transcription]; Region: LytR; COG1316 561304005169 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 561304005170 probable fatty-acyl CoA reductase 561304005171 short-chain alcohol dehydrogenase 561304005172 enoyl-CoA hydratase/isomerase superfamily 561304005173 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 561304005174 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 561304005175 active site 561304005176 homotetramer interface [polypeptide binding]; other site 561304005178 unknown membrane protein 561304005179 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 561304005180 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304005181 acyl-activating enzyme (AAE) consensus motif; other site 561304005182 AMP binding site [chemical binding]; other site 561304005183 active site 561304005184 CoA binding site [chemical binding]; other site 561304005185 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 561304005186 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 561304005187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 561304005188 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 561304005189 active site 561304005190 oxidoreductase 561304005191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304005192 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 561304005193 substrate binding site [chemical binding]; other site 561304005194 oxyanion hole (OAH) forming residues; other site 561304005195 trimer interface [polypeptide binding]; other site 561304005196 acyl-CoA synthase 561304005197 transcriptional regulator 561304005198 O-succinylbenzoate synthase; Provisional; Region: PRK02901 561304005199 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 561304005200 active site 561304005201 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 561304005202 TAP-like protein; Region: Abhydrolase_4; pfam08386 561304005203 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 561304005204 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 561304005205 dimer interface [polypeptide binding]; other site 561304005206 tetramer interface [polypeptide binding]; other site 561304005207 PYR/PP interface [polypeptide binding]; other site 561304005208 TPP binding site [chemical binding]; other site 561304005209 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 561304005210 TPP-binding site; other site 561304005211 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 561304005213 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 561304005214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005215 S-adenosylmethionine binding site [chemical binding]; other site 561304005216 Protein of unknown function (DUF732); Region: DUF732; pfam05305 561304005217 methyl transferase 561304005218 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 561304005219 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 561304005220 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 561304005221 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 561304005222 substrate binding pocket [chemical binding]; other site 561304005223 chain length determination region; other site 561304005224 substrate-Mg2+ binding site; other site 561304005225 catalytic residues [active] 561304005226 aspartate-rich region 1; other site 561304005227 active site lid residues [active] 561304005228 aspartate-rich region 2; other site 561304005229 heat shock protein HtpX; Provisional; Region: PRK03072 561304005230 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 561304005231 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 561304005232 Sulfate transporter family; Region: Sulfate_transp; pfam00916 561304005233 glycerol-3-phosphate dehydrogenase 561304005234 Probable monooxygenasemonoxygenase 561304005236 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 561304005237 Domain of unknown function (DUF1814); Region: DUF1814; cl00973 561304005238 probable membrane protein 561304005239 transcriptional regulator (LysR family) 561304005240 possible oxidoreductase 561304005241 probable ABC-transporter 561304005242 probable peptide transport system permease 561304005243 probable peptide transport system permease 561304005244 peptide transport system peptide-binding protein 561304005245 acetyl-CoA synthase 561304005246 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 561304005247 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 561304005248 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 561304005249 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 561304005250 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 561304005251 putative active site [active] 561304005252 putative CoA binding site [chemical binding]; other site 561304005253 nudix motif; other site 561304005254 metal binding site [ion binding]; metal-binding site 561304005255 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 561304005256 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561304005257 catalytic residues [active] 561304005258 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 561304005259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 561304005260 minor groove reading motif; other site 561304005261 helix-hairpin-helix signature motif; other site 561304005262 substrate binding pocket [chemical binding]; other site 561304005263 active site 561304005264 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 561304005265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 561304005266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 561304005267 ligand binding site [chemical binding]; other site 561304005268 flexible hinge region; other site 561304005269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 561304005270 putative switch regulator; other site 561304005271 non-specific DNA interactions [nucleotide binding]; other site 561304005272 DNA binding site [nucleotide binding] 561304005273 sequence specific DNA binding site [nucleotide binding]; other site 561304005274 putative cAMP binding site [chemical binding]; other site 561304005275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561304005276 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 561304005277 homotrimer interaction site [polypeptide binding]; other site 561304005278 putative active site [active] 561304005279 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 561304005280 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 561304005281 P loop; other site 561304005282 Nucleotide binding site [chemical binding]; other site 561304005283 DTAP/Switch II; other site 561304005284 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 561304005285 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 561304005286 DTAP/Switch II; other site 561304005287 Switch I; other site 561304005288 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 561304005289 Transcription factor WhiB; Region: Whib; pfam02467 561304005290 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 561304005291 Transglycosylase; Region: Transgly; pfam00912 561304005292 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 561304005293 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561304005294 phosphodiesterase YaeI; Provisional; Region: PRK11340 561304005295 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 561304005296 putative active site [active] 561304005297 putative metal binding site [ion binding]; other site 561304005298 Probable lyase, cysteine metabolism 561304005300 Predicted membrane protein/domain [Function unknown]; Region: COG1714 561304005301 Predicted transcriptional regulators [Transcription]; Region: COG1695 561304005302 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 561304005303 glycerol kinase; Provisional; Region: glpK; PRK00047 561304005304 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 561304005305 N- and C-terminal domain interface [polypeptide binding]; other site 561304005306 active site 561304005307 MgATP binding site [chemical binding]; other site 561304005308 catalytic site [active] 561304005309 metal binding site [ion binding]; metal-binding site 561304005310 putative homotetramer interface [polypeptide binding]; other site 561304005311 glycerol binding site [chemical binding]; other site 561304005312 homodimer interface [polypeptide binding]; other site 561304005314 Probable methyltransferase 561304005317 possible [gamma]-glutamylcysteine synthase 561304005318 PknH-like extracellular domain; Region: PknH_C; pfam14032 561304005319 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 561304005320 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 561304005321 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 561304005322 aspartate kinase; Reviewed; Region: PRK06635 561304005323 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 561304005324 putative nucleotide binding site [chemical binding]; other site 561304005325 putative catalytic residues [active] 561304005326 putative Mg ion binding site [ion binding]; other site 561304005327 putative aspartate binding site [chemical binding]; other site 561304005328 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 561304005329 putative allosteric regulatory site; other site 561304005330 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 561304005331 putative allosteric regulatory residue; other site 561304005332 2-isopropylmalate synthase; Validated; Region: PRK03739 561304005333 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 561304005334 active site 561304005335 catalytic residues [active] 561304005336 metal binding site [ion binding]; metal-binding site 561304005337 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 561304005338 DNA polymerase III [epsilon] chain 561304005339 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 561304005340 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 561304005341 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 561304005342 catalytic triad [active] 561304005344 recombination protein RecR; Reviewed; Region: recR; PRK00076 561304005345 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 561304005346 RecR protein; Region: RecR; pfam02132 561304005347 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 561304005348 putative active site [active] 561304005349 putative metal-binding site [ion binding]; other site 561304005350 tetramer interface [polypeptide binding]; other site 561304005351 hypothetical protein; Validated; Region: PRK00153 561304005352 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 561304005353 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 561304005354 active site 561304005355 metal binding site [ion binding]; metal-binding site 561304005356 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 561304005357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 561304005358 FAD binding domain; Region: FAD_binding_4; pfam01565 561304005359 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 561304005360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005361 S-adenosylmethionine binding site [chemical binding]; other site 561304005362 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 561304005363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304005364 Walker A motif; other site 561304005365 ATP binding site [chemical binding]; other site 561304005366 Walker B motif; other site 561304005367 arginine finger; other site 561304005368 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 561304005369 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 561304005370 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 561304005371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561304005372 catalytic residue [active] 561304005373 probable esterase 561304005374 probable cutinase precursor 561304005375 possible sugar transporter 561304005376 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 561304005377 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 561304005378 cyclase homology domain; Region: CHD; cd07302 561304005379 nucleotidyl binding site; other site 561304005380 metal binding site [ion binding]; metal-binding site 561304005381 dimer interface [polypeptide binding]; other site 561304005382 Predicted ATPase [General function prediction only]; Region: COG3899 561304005383 AAA ATPase domain; Region: AAA_16; pfam13191 561304005385 L-asparaginase 561304005386 probable sugar transporter 561304005387 transcriptional regulator (Crp/Fnr family) 561304005388 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 561304005389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005390 S-adenosylmethionine binding site [chemical binding]; other site 561304005391 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 561304005392 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 561304005393 homodimer interface [polypeptide binding]; other site 561304005394 active site 561304005395 TDP-binding site; other site 561304005396 acceptor substrate-binding pocket; other site 561304005397 acyltransferase PapA5; Provisional; Region: PRK09294 561304005398 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 561304005399 daunorubicin resistance protein C; Region: drrC; TIGR01248 561304005400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 561304005401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 561304005402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561304005403 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 561304005404 Walker A/P-loop; other site 561304005405 ATP binding site [chemical binding]; other site 561304005406 Q-loop/lid; other site 561304005407 ABC transporter signature motif; other site 561304005408 Walker B; other site 561304005409 D-loop; other site 561304005410 H-loop/switch region; other site 561304005411 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304005412 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 561304005413 active site 561304005414 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 561304005415 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 561304005416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 561304005417 Condensation domain; Region: Condensation; pfam00668 561304005418 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 561304005419 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304005420 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304005421 active site 561304005422 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 561304005423 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304005424 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 561304005425 KR domain; Region: KR; pfam08659 561304005426 putative NADP binding site [chemical binding]; other site 561304005427 active site 561304005428 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304005429 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304005430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304005431 active site 561304005432 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 561304005433 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304005434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304005435 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 561304005436 Enoylreductase; Region: PKS_ER; smart00829 561304005437 NAD(P) binding site [chemical binding]; other site 561304005438 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 561304005439 KR domain; Region: KR; pfam08659 561304005440 putative NADP binding site [chemical binding]; other site 561304005441 active site 561304005442 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304005443 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304005444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304005445 active site 561304005446 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 561304005447 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 561304005448 KR domain; Region: KR; pfam08659 561304005449 NADP binding site [chemical binding]; other site 561304005450 active site 561304005451 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304005452 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 561304005453 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 561304005454 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 561304005455 active site 561304005456 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 561304005457 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 561304005458 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 561304005459 KR domain; Region: KR; pfam08659 561304005460 NADP binding site [chemical binding]; other site 561304005461 active site 561304005462 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 561304005463 acyl-CoA synthetase; Validated; Region: PRK05850 561304005464 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 561304005465 acyl-activating enzyme (AAE) consensus motif; other site 561304005466 active site 561304005467 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 561304005469 two-component response regulator 561304005470 sensor histidine kinase 561304005472 probable alkyl sulfatase 561304005473 acyl-CoA dehydrogenase 561304005474 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 561304005475 similar to osmoprotection proteins 561304005476 transposase 561304005477 PPE-family protein 561304005478 ECF-type sigma factor 561304005480 unknown fatty acid methyltransferase 561304005482 integral membrane protein 561304005483 conserved large membrane protein 561304005484 transcriptional regulator 561304005485 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 561304005486 Transport protein; Region: actII; TIGR00833 561304005487 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 561304005488 enoyl-CoA hydratase/isomerase superfamily 561304005489 probable peptidase 561304005490 aldehyde dehydrogenase 561304005493 unknown possible membrane protein 561304005494 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 561304005495 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 561304005496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561304005497 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 561304005499 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 561304005500 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 561304005501 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 561304005502 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 561304005503 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 561304005504 cystathionine gamma-synthase; Provisional; Region: PRK07811 561304005505 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 561304005506 homodimer interface [polypeptide binding]; other site 561304005507 substrate-cofactor binding pocket; other site 561304005508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304005509 catalytic residue [active] 561304005510 RDD family; Region: RDD; pfam06271 561304005511 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 561304005512 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 561304005513 dimer interface [polypeptide binding]; other site 561304005514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304005515 catalytic residue [active] 561304005516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 561304005517 probable esterase 561304005519 acetyl-CoA C-acetyltransferase 561304005520 Predicted membrane protein [Function unknown]; Region: COG4760 561304005521 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 561304005522 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 561304005523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304005524 substrate binding site [chemical binding]; other site 561304005525 oxyanion hole (OAH) forming residues; other site 561304005526 trimer interface [polypeptide binding]; other site 561304005527 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 561304005528 enoyl-CoA hydratase; Provisional; Region: PRK05862 561304005529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304005530 substrate binding site [chemical binding]; other site 561304005531 oxyanion hole (OAH) forming residues; other site 561304005532 trimer interface [polypeptide binding]; other site 561304005534 UDP-glucose 4-epimerase 561304005535 phosphorylase from Pnp/MtaP family 2 561304005536 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 561304005537 UbiA prenyltransferase family; Region: UbiA; pfam01040 561304005539 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 561304005540 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 561304005541 ResB-like family; Region: ResB; pfam05140 561304005542 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 561304005543 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 561304005544 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 561304005545 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561304005546 catalytic residues [active] 561304005547 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304005548 catalytic core [active] 561304005549 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 561304005550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 561304005551 inhibitor-cofactor binding pocket; inhibition site 561304005552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304005553 catalytic residue [active] 561304005555 probable 4-amino butyrate transporter 561304005557 probable membrane protein 561304005558 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 561304005559 dimer interface [polypeptide binding]; other site 561304005560 active site 561304005561 Schiff base residues; other site 561304005562 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 561304005563 active site 561304005564 SAM binding site [chemical binding]; other site 561304005565 homodimer interface [polypeptide binding]; other site 561304005566 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 561304005567 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 561304005568 active site 561304005569 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 561304005570 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 561304005571 domain interfaces; other site 561304005572 active site 561304005573 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 561304005574 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 561304005575 tRNA; other site 561304005576 putative tRNA binding site [nucleotide binding]; other site 561304005577 putative NADP binding site [chemical binding]; other site 561304005578 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 561304005580 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 561304005581 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 561304005582 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 561304005583 active site 561304005584 catalytic site [active] 561304005585 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 561304005586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 561304005587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005588 S-adenosylmethionine binding site [chemical binding]; other site 561304005589 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 561304005590 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 561304005591 putative acyl-acceptor binding pocket; other site 561304005592 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 561304005593 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 561304005594 putative NAD(P) binding site [chemical binding]; other site 561304005595 active site 561304005596 putative substrate binding site [chemical binding]; other site 561304005597 DNA binding domain, excisionase family; Region: excise; TIGR01764 561304005598 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 561304005599 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 561304005601 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 561304005602 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 561304005603 exopolyphosphatase; Region: exo_poly_only; TIGR03706 561304005604 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 561304005605 transcriptional regulator (GntR family) 561304005607 gmc-type oxidoreductase 561304005608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561304005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561304005610 active site 561304005611 phosphorylation site [posttranslational modification] 561304005612 intermolecular recognition site; other site 561304005613 dimerization interface [polypeptide binding]; other site 561304005614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561304005615 DNA binding site [nucleotide binding] 561304005616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561304005617 dimer interface [polypeptide binding]; other site 561304005618 phosphorylation site [posttranslational modification] 561304005619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561304005620 ATP binding site [chemical binding]; other site 561304005621 Mg2+ binding site [ion binding]; other site 561304005622 G-X-G motif; other site 561304005623 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 561304005624 ATP-binding site [chemical binding]; other site 561304005625 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561304005626 catalytic core [active] 561304005627 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 561304005628 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 561304005629 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 561304005630 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 561304005631 putative ADP-binding pocket [chemical binding]; other site 561304005632 transcriptional regulator (ROK family) 561304005633 oxidoreductase 561304005634 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 561304005635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 561304005636 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 561304005637 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 561304005638 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 561304005639 FAD binding domain; Region: FAD_binding_4; pfam01565 561304005640 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 561304005642 Predicted amidohydrolase [General function prediction only]; Region: COG0388 561304005643 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 561304005644 putative active site [active] 561304005645 catalytic triad [active] 561304005646 putative dimer interface [polypeptide binding]; other site 561304005647 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 561304005648 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 561304005649 intersubunit interface [polypeptide binding]; other site 561304005650 active site 561304005651 catalytic residue [active] 561304005652 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 561304005653 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 561304005654 transcriptional regulator (PbsX/Xre family) 561304005655 possible membrane protein 561304005656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304005657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304005659 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 561304005660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 561304005661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005662 S-adenosylmethionine binding site [chemical binding]; other site 561304005663 unknown mycolic acid methyltransferase 561304005664 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 561304005665 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 561304005666 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 561304005667 isocitrate lyase 561304005668 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 561304005669 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 561304005670 active site 2 [active] 561304005671 active site 1 [active] 561304005672 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 561304005673 active site 2 [active] 561304005674 transcriptional regulator (PbsX/Xre family) 561304005675 Uncharacterized conserved protein [Function unknown]; Region: COG2128 561304005676 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 561304005677 possible hemolysin 561304005678 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 561304005679 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 561304005680 catalytic residue [active] 561304005681 putative FPP diphosphate binding site; other site 561304005682 putative FPP binding hydrophobic cleft; other site 561304005683 dimer interface [polypeptide binding]; other site 561304005684 putative IPP diphosphate binding site; other site 561304005685 osmoprotection ABC transporter 561304005686 transport system permease 561304005688 prephenate dehydrogenase; Validated; Region: PRK06545 561304005689 prephenate dehydrogenase; Validated; Region: PRK08507 561304005690 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 561304005691 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 561304005692 nucleoside/Zn binding site; other site 561304005693 dimer interface [polypeptide binding]; other site 561304005694 catalytic motif [active] 561304005695 possible glycerolphosphodiesterase 561304005696 Uncharacterized conserved protein [Function unknown]; Region: COG0393 561304005697 PE protein 561304005698 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 561304005700 CO dehydrogenase gene cluster 561304005701 CO dehydrogenase gene cluster 561304005702 Possible membrane protein 561304005704 transcriptional regulator (LysR family) 561304005705 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 561304005706 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 561304005708 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561304005709 active site 561304005710 ketoacyl reductase 561304005711 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 561304005712 Clp amino terminal domain; Region: Clp_N; pfam02861 561304005713 Clp amino terminal domain; Region: Clp_N; pfam02861 561304005714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304005715 Walker A motif; other site 561304005716 ATP binding site [chemical binding]; other site 561304005717 Walker B motif; other site 561304005718 arginine finger; other site 561304005719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304005720 Walker A motif; other site 561304005721 ATP binding site [chemical binding]; other site 561304005722 Walker B motif; other site 561304005723 arginine finger; other site 561304005724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 561304005725 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 561304005726 similar to oxidoreductases 561304005727 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 561304005728 DNA binding residues [nucleotide binding] 561304005729 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 561304005730 putative dimer interface [polypeptide binding]; other site 561304005731 chaperone protein DnaJ; Provisional; Region: PRK14279 561304005732 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 561304005733 HSP70 interaction site [polypeptide binding]; other site 561304005734 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 561304005735 Zn binding sites [ion binding]; other site 561304005736 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 561304005737 dimer interface [polypeptide binding]; other site 561304005738 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 561304005739 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 561304005740 dimer interface [polypeptide binding]; other site 561304005741 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 561304005742 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 561304005743 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 561304005744 nucleotide binding site [chemical binding]; other site 561304005745 NEF interaction site [polypeptide binding]; other site 561304005746 SBD interface [polypeptide binding]; other site 561304005747 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 561304005748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561304005749 substrate binding site [chemical binding]; other site 561304005750 oxyanion hole (OAH) forming residues; other site 561304005751 trimer interface [polypeptide binding]; other site 561304005752 CO dehydrogenase gene cluster 561304005754 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 561304005755 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 561304005756 4Fe-4S binding domain; Region: Fer4; cl02805 561304005757 4Fe-4S binding domain; Region: Fer4; pfam00037 561304005758 Cysteine-rich domain; Region: CCG; pfam02754 561304005759 Cysteine-rich domain; Region: CCG; pfam02754 561304005760 Treacher Collins syndrome protein Treacle; Region: Treacle; pfam03546 561304005761 aminotransferase AlaT; Validated; Region: PRK09265 561304005762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561304005763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561304005764 homodimer interface [polypeptide binding]; other site 561304005765 catalytic residue [active] 561304005766 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 561304005767 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 561304005768 substrate binding site; other site 561304005769 tetramer interface; other site 561304005772 UDP-glucose dehydrogenase/GDP-mannose 561304005773 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 561304005774 trimer interface [polypeptide binding]; other site 561304005775 active site 561304005778 enoyl-CoA hydratase/isomerase superfamily 561304005779 probable sugar transport protein 561304005781 immunogenic protein Mpb64/Mpt64 561304005782 possible membrane protein 561304005783 unknown membrane protein 561304005784 probable [beta]-1,3-glucanase 561304005785 unknown hydrophobic protein 561304005789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 561304005792 proable arylsulfatase 561304005794 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 561304005795 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 561304005796 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 561304005797 active site 561304005798 catalytic residues [active] 561304005799 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 561304005800 EspG family; Region: ESX-1_EspG; pfam14011 561304005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 561304005802 PE-family protein 561304005803 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 561304005804 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304005805 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 561304005806 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304005807 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561304005808 Protein of unknown function (DUF690); Region: DUF690; pfam05108 561304005809 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 561304005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561304005811 Walker A motif; other site 561304005812 ATP binding site [chemical binding]; other site 561304005813 Walker B motif; other site 561304005814 arginine finger; other site 561304005815 PPE-family protein 561304005818 acyl-CoA synthase 561304005820 transcriptional regulator 561304005822 acyl-CoA dehydrogenase 561304005823 acyl-CoA synthetase; Validated; Region: PRK07788 561304005824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304005825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304005826 active site 561304005827 CoA binding site [chemical binding]; other site 561304005828 AMP binding site [chemical binding]; other site 561304005830 iron transport protein FeIII dicitrate transporter 561304005831 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 561304005832 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 561304005833 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 561304005834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561304005835 Coenzyme A binding pocket [chemical binding]; other site 561304005836 nitrite extrusion protein1 561304005838 probable nitrite reductase small subunit 561304005839 nitrite reductase flavoprotein 561304005840 possible heat shock protein 561304005841 probable membrane anchor protein 561304005842 probable flavoprotein subunit of Rv0247c 561304005843 probable iron-sulphur protein 561304005844 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 561304005845 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 561304005846 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 561304005847 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 561304005848 FAD binding site [chemical binding]; other site 561304005849 substrate binding site [chemical binding]; other site 561304005850 catalytic residues [active] 561304005851 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 561304005852 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 561304005853 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 561304005854 dimer interface [polypeptide binding]; other site 561304005855 active site 561304005856 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 561304005857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561304005858 NAD(P) binding site [chemical binding]; other site 561304005859 active site 561304005860 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 561304005861 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 561304005862 active site 2 [active] 561304005863 active site 1 [active] 561304005864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304005865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304005866 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 561304005867 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 561304005868 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 561304005869 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 561304005870 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 561304005871 glycerophosphoryl diester phosphodiesterase 561304005873 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 561304005874 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 561304005875 NAD(P) binding site [chemical binding]; other site 561304005876 catalytic residues [active] 561304005877 ribonucleoside-diphosphate reductase B2 561304005878 transcriptional regulator (TetR/AcrR family) 561304005881 acyl-CoA dehydrogenase 561304005883 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 561304005884 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 561304005885 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 561304005886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561304005887 Methyltransferase domain; Region: Methyltransf_11; pfam08241 561304005888 aldehyde dehydrogenase (possible betB) 561304005889 acyl-CoA synthase 561304005890 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 561304005891 Permease; Region: Permease; pfam02405 561304005892 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 561304005893 Permease; Region: Permease; pfam02405 561304005894 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 561304005895 mce related protein; Region: MCE; pfam02470 561304005896 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 561304005897 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 561304005898 mce related protein; Region: MCE; pfam02470 561304005899 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 561304005900 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 561304005901 mce related protein; Region: MCE; pfam02470 561304005902 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 561304005903 mce related protein; Region: MCE; pfam02470 561304005904 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 561304005905 mce related protein; Region: MCE; pfam02470 561304005906 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 561304005907 mce related protein; Region: MCE; pfam02470 561304005908 Predicted membrane protein/domain [Function unknown]; Region: COG1714 561304005909 lipoprotein 561304005910 Predicted membrane protein [Function unknown]; Region: COG1511 561304005911 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 561304005912 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 561304005914 sigma-70 factors ECF subfamily 561304005915 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 561304005916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 561304005917 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 561304005918 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 561304005919 [beta]-glucosidase 561304005920 polyketide synthase 561304005921 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 561304005922 6-phosphogluconate dehydratase; Region: edd; TIGR01196 561304005923 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 561304005924 putative homodimer interface [polypeptide binding]; other site 561304005925 putative homotetramer interface [polypeptide binding]; other site 561304005926 putative allosteric switch controlling residues; other site 561304005927 putative metal binding site [ion binding]; other site 561304005928 putative homodimer-homodimer interface [polypeptide binding]; other site 561304005929 probable chloramphenicol resistance protein 561304005932 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 561304005933 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 561304005934 active site 561304005935 Zn binding site [ion binding]; other site 561304005936 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 561304005937 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 561304005938 Predicted integral membrane protein [Function unknown]; Region: COG0392 561304005939 probable membrane protein 561304005940 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 561304005941 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 561304005942 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 561304005943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561304005944 S-adenosylmethionine binding site [chemical binding]; other site 561304005946 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 561304005947 active site 561304005948 substrate-binding site [chemical binding]; other site 561304005949 metal-binding site [ion binding] 561304005950 GTP binding site [chemical binding]; other site 561304005951 acyl-CoA synthase 561304005952 acyl-CoA dehydrogenase 561304005953 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 561304005954 putative active site [active] 561304005955 putative catalytic site [active] 561304005956 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 561304005957 active site 2 [active] 561304005958 active site 1 [active] 561304005959 acyl-CoA synthase 561304005960 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 561304005961 putative hydrophobic ligand binding site [chemical binding]; other site 561304005962 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 561304005963 FAD binding domain; Region: FAD_binding_4; pfam01565 561304005964 PE-family protein 561304005965 transcriptional regulator (TetR/AcrR family) 561304005966 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 561304005967 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 561304005968 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 561304005969 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 561304005970 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 561304005971 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 561304005972 ligand binding site [chemical binding]; other site 561304005973 homodimer interface [polypeptide binding]; other site 561304005974 NAD(P) binding site [chemical binding]; other site 561304005975 trimer interface B [polypeptide binding]; other site 561304005976 trimer interface A [polypeptide binding]; other site 561304005977 acyl-CoA dehydrogenase 561304005978 oxidoreductase 561304005979 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 561304005980 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 561304005981 NAD(P) binding site [chemical binding]; other site 561304005982 catalytic residues [active] 561304005983 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 561304005984 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 561304005986 transcriptional regulator 561304005987 probable chloride channel 561304005989 oxidoreductase 561304005991 methionine sulfoxide reductase A; Provisional; Region: PRK14054 561304005992 cytochrome p450 561304005993 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 561304005994 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 561304005995 NodB motif; other site 561304005996 active site 561304005997 catalytic site [active] 561304005998 metal binding site [ion binding]; metal-binding site 561304006002 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 561304006003 active site 561304006004 metal binding site [ion binding]; metal-binding site 561304006005 homotetramer interface [polypeptide binding]; other site 561304006006 Predicted esterase [General function prediction only]; Region: COG0627 561304006007 S-formylglutathione hydrolase; Region: PLN02442 561304006010 probable glycosyl hydrolase 561304006011 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 561304006012 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 561304006013 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 561304006014 elongation factor G 561304006015 acyl-CoA synthetase; Validated; Region: PRK05852 561304006016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304006017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 561304006018 acyl-activating enzyme (AAE) consensus motif; other site 561304006019 acyl-activating enzyme (AAE) consensus motif; other site 561304006020 AMP binding site [chemical binding]; other site 561304006021 active site 561304006022 CoA binding site [chemical binding]; other site 561304006023 oxalyl-CoA decarboxylase 561304006024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 561304006025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 561304006026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 561304006027 dimerization interface [polypeptide binding]; other site 561304006028 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 561304006029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 561304006030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 561304006031 acyl-CoA synthase 561304006032 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 561304006033 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 561304006035 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 561304006036 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 561304006037 active site 561304006038 catalytic triad [active] 561304006039 oxyanion hole [active] 561304006040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 561304006041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561304006042 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 561304006043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561304006044 motif II; other site 561304006045 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 561304006046 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 561304006047 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 561304006048 sensor histidine kinase 561304006049 possible membrane protein 561304006050 probable ATP-binding transport protein 561304006051 probable oxidoreductase 561304006052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561304006053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561304006054 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 561304006055 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 561304006056 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 561304006057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 561304006058 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 561304006059 Uncharacterized conserved protein [Function unknown]; Region: COG2308 561304006060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 561304006061 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 561304006062 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 561304006063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 561304006064 Walker A motif; other site 561304006065 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 561304006066 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 561304006067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 561304006068 Walker A motif; other site 561304006069 ATP binding site [chemical binding]; other site 561304006070 Walker B motif; other site 561304006071 DNA binding loops [nucleotide binding] 561304006073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 561304006074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 561304006075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 561304006076 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 561304006077 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 561304006078 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 561304006079 dimer interface [polypeptide binding]; other site 561304006080 ssDNA binding site [nucleotide binding]; other site 561304006081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561304006082 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 561304006084 Predicted integral membrane protein [Function unknown]; Region: COG5650 561304006085 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 561304006086 Transglycosylase; Region: Transgly; pfam00912 561304006087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561304006089 Predicted transcriptional regulators [Transcription]; Region: COG1695 561304006090 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 561304006091 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 561304006092 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 561304006093 possible dihydrolipoamide acetyltransferase 561304006094 possible monooxygenase 561304006095 ABC transporter 561304006096 Transcriptional regulators [Transcription]; Region: MarR; COG1846 561304006097 MarR family; Region: MarR; pfam01047 561304006098 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 561304006099 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 561304006100 active site 561304006101 NTP binding site [chemical binding]; other site 561304006102 metal binding triad [ion binding]; metal-binding site 561304006103 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 561304006104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561304006105 Zn2+ binding site [ion binding]; other site 561304006106 Mg2+ binding site [ion binding]; other site 561304006107 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 561304006108 active site 561304006109 Ap6A binding site [chemical binding]; other site 561304006110 nudix motif; other site 561304006111 metal binding site [ion binding]; metal-binding site 561304006112 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 561304006113 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 561304006114 probable sigma factor, similar to SigE 561304006116 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 561304006117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561304006118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561304006119 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561304006120 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561304006121 catalytic residues [active] 561304006122 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 561304006123 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 561304006124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 561304006125 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 561304006126 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 561304006127 active site 561304006128 metal binding site [ion binding]; metal-binding site 561304006129 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 561304006130 ParB-like nuclease domain; Region: ParBc; pfam02195 561304006131 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 561304006132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 561304006133 P-loop; other site 561304006134 Magnesium ion binding site [ion binding]; other site 561304006135 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 561304006136 Magnesium ion binding site [ion binding]; other site 561304006137 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 561304006138 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 561304006139 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 561304006140 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 561304006141 G-X-X-G motif; other site 561304006142 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 561304006143 RxxxH motif; other site 561304006144 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 561304006145 possible hemolysin 561304006146 ribonuclease P; Reviewed; Region: rnpA; PRK00588 561304006147 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399