-- dump date 20140619_152919 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002502760.1 221229344 7327331 1..1566 1 NC_011896.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1566 dnaA 7327331 dnaA Mycobacterium leprae Br4923 chromosomal replication initiation protein YP_002502760.1 1 D 561304 CDS YP_002502761.1 221229345 7326174 2081..3280 1 NC_011896.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3280 dnaN 7326174 dnaN Mycobacterium leprae Br4923 DNA polymerase III subunit beta YP_002502761.1 2081 D 561304 CDS YP_002502762.1 221229346 7326182 3281..4438 1 NC_011896.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4438 recF 7326182 recF Mycobacterium leprae Br4923 recombination protein F YP_002502762.1 3281 D 561304 CDS YP_002502763.1 221229347 7326610 4435..5004 1 NC_011896.1 hypothetical protein 5004 7326610 MLBr_00004 Mycobacterium leprae Br4923 hypothetical protein YP_002502763.1 4435 D 561304 CDS YP_002502764.1 221229348 7327009 5229..7265 1 NC_011896.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7265 gyrB 7327009 gyrB Mycobacterium leprae Br4923 DNA gyrase subunit B YP_002502764.1 5229 D 561304 CDS YP_002502765.1 221229349 7324668 7318..11067 1 NC_011896.1 DNA gyrase subunit A 11067 gyrA 7324668 gyrA Mycobacterium leprae Br4923 DNA gyrase subunit A YP_002502765.1 7318 D 561304 CDS YP_002502766.1 221229350 7324667 11195..12106 1 NC_011896.1 hypothetical protein 12106 7324667 MLBr_00007 Mycobacterium leprae Br4923 hypothetical protein YP_002502766.1 11195 D 561304 CDS YP_002502767.1 221229351 7327199 complement(12856..13230) 1 NC_011896.1 hypothetical protein 13230 7327199 MLBr_00008 Mycobacterium leprae Br4923 hypothetical protein YP_002502767.1 12856 R 561304 CDS YP_002502768.1 221229352 7327011 13775..13966 1 NC_011896.1 hypothetical protein 13966 7327011 MLBr_00009 Mycobacterium leprae Br4923 hypothetical protein YP_002502768.1 13775 D 561304 CDS YP_002502769.1 221229353 7327013 15989..16537 1 NC_011896.1 peptidyl-prolyl cis-trans isomerase 16537 ppiA 7327013 ppiA Mycobacterium leprae Br4923 peptidyl-prolyl cis-trans isomerase YP_002502769.1 15989 D 561304 CDS YP_002502770.1 221229354 7325000 complement(16562..16975) 1 NC_011896.1 hypothetical protein 16975 7325000 MLBr_00012 Mycobacterium leprae Br4923 hypothetical protein YP_002502770.1 16562 R 561304 CDS YP_002502771.1 221229355 7327014 complement(17130..17411) 1 NC_011896.1 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 17411 7327014 MLBr_00013 Mycobacterium leprae Br4923 septation inhibitor protein YP_002502771.1 17130 R 561304 CDS YP_002502772.1 221229356 7327016 18321..19019 1 NC_011896.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 19019 pabA 7327016 pabA Mycobacterium leprae Br4923 para-aminobenzoate synthase component II YP_002502772.1 18321 D 561304 CDS YP_002502773.1 221229357 7327345 complement(18997..20865) 1 NC_011896.1 serine/threonine protein kinase 20865 pknB 7327345 pknB Mycobacterium leprae Br4923 serine/threonine protein kinase YP_002502773.1 18997 R 561304 CDS YP_002502774.1 221229358 7327403 complement(20875..22188) 1 NC_011896.1 serine/threonine protein kinase 22188 pknA 7327403 pknA Mycobacterium leprae Br4923 serine/threonine protein kinase YP_002502774.1 20875 R 561304 CDS YP_002502775.1 221229359 7327402 complement(22185..23663) 1 NC_011896.1 penicillin-binding protein 23663 pbpA 7327402 pbpA Mycobacterium leprae Br4923 penicillin-binding protein YP_002502775.1 22185 R 561304 CDS YP_002502776.1 221229360 7327354 complement(23660..25057) 1 NC_011896.1 cell-division protein 25057 rodA 7327354 rodA Mycobacterium leprae Br4923 cell-division protein YP_002502776.1 23660 R 561304 CDS YP_002502777.1 221229361 7326638 complement(25054..26583) 1 NC_011896.1 hypothetical protein 26583 7326638 MLBr_00020 Mycobacterium leprae Br4923 hypothetical protein YP_002502777.1 25054 R 561304 CDS YP_002502778.1 221229362 7327017 complement(26580..27047) 1 NC_011896.1 hypothetical protein 27047 7327017 MLBr_00021 Mycobacterium leprae Br4923 hypothetical protein YP_002502778.1 26580 R 561304 CDS YP_002502779.1 221229363 7327018 complement(27169..28635) 1 NC_011896.1 hypothetical protein 28635 7327018 MLBr_00022 Mycobacterium leprae Br4923 hypothetical protein YP_002502779.1 27169 R 561304 CDS YP_002502780.1 221229364 7325378 complement(28950..29261) 1 NC_011896.1 hypothetical protein 29261 7325378 MLBr_00023 Mycobacterium leprae Br4923 hypothetical protein YP_002502780.1 28950 R 561304 CDS YP_002502781.1 221229365 7327020 29771..30022 1 NC_011896.1 hypothetical protein 30022 7327020 MLBr_00024 Mycobacterium leprae Br4923 hypothetical protein YP_002502781.1 29771 D 561304 CDS YP_002502782.1 221229366 7327021 complement(30289..30579) 1 NC_011896.1 hypothetical protein 30579 7327021 MLBr_00025 Mycobacterium leprae Br4923 hypothetical protein YP_002502782.1 30289 R 561304 CDS YP_002502783.1 221229367 7327023 33096..33701 1 NC_011896.1 hypothetical protein 33701 7327023 MLBr_00028 Mycobacterium leprae Br4923 hypothetical protein YP_002502783.1 33096 D 561304 CDS YP_002502784.1 221229368 7327024 complement(34029..34634) 1 NC_011896.1 hypothetical protein 34634 7327024 MLBr_00029 Mycobacterium leprae Br4923 hypothetical protein YP_002502784.1 34029 R 561304 CDS YP_002502785.1 221229369 7327025 complement(34746..35087) 1 NC_011896.1 hypothetical protein 35087 7327025 MLBr_00030 Mycobacterium leprae Br4923 hypothetical protein YP_002502785.1 34746 R 561304 CDS YP_002502786.1 221229370 7327026 complement(35283..36119) 1 NC_011896.1 hypothetical protein 36119 7327026 MLBr_00031 Mycobacterium leprae Br4923 hypothetical protein YP_002502786.1 35283 R 561304 CDS YP_002502787.1 221229371 7327027 36317..39235 1 NC_011896.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 39235 leuS 7327027 leuS Mycobacterium leprae Br4923 leucyl-tRNA synthetase YP_002502787.1 36317 D 561304 CDS YP_002502788.1 221229372 7325787 50652..51992 1 NC_011896.1 protease 51992 7325787 MLBr_00041 Mycobacterium leprae Br4923 protease YP_002502788.1 50652 D 561304 CDS YP_002502789.1 221229373 7325788 51989..53392 1 NC_011896.1 hypothetical protein 53392 7325788 MLBr_00042 Mycobacterium leprae Br4923 hypothetical protein YP_002502789.1 51989 D 561304 CDS YP_002502790.1 221229374 7325790 54694..55035 1 NC_011896.1 hypothetical protein 55035 7325790 MLBr_00044 Mycobacterium leprae Br4923 hypothetical protein YP_002502790.1 54694 D 561304 CDS YP_002502791.1 221229375 7325793 complement(58016..59554) 1 NC_011896.1 hypothetical protein 59554 7325793 MLBr_00047 Mycobacterium leprae Br4923 hypothetical protein YP_002502791.1 58016 R 561304 CDS YP_002502792.1 221229376 7325794 complement(59551..61311) 1 NC_011896.1 hypothetical protein 61311 7325794 MLBr_00048 Mycobacterium leprae Br4923 hypothetical protein YP_002502792.1 59551 R 561304 CDS YP_002502793.1 221229377 7325795 complement(61402..61689) 1 NC_011896.1 hypothetical protein 61689 7325795 MLBr_00049 Mycobacterium leprae Br4923 hypothetical protein YP_002502793.1 61402 R 561304 CDS YP_002502794.1 221229378 7325796 complement(61716..62018) 1 NC_011896.1 hypothetical protein 62018 7325796 MLBr_00050 Mycobacterium leprae Br4923 hypothetical protein YP_002502794.1 61716 R 561304 CDS YP_002502795.1 221229379 7325797 complement(62197..63105) 1 NC_011896.1 PPE family protein 63105 7325797 MLBr_00051 Mycobacterium leprae Br4923 PPE family protein YP_002502795.1 62197 R 561304 CDS YP_002502796.1 221229380 7325798 complement(63315..65108) 1 NC_011896.1 hypothetical protein 65108 7325798 MLBr_00052 Mycobacterium leprae Br4923 hypothetical protein YP_002502796.1 63315 R 561304 CDS YP_002502797.1 221229381 7325799 complement(65182..67416) 1 NC_011896.1 hypothetical protein 67416 7325799 MLBr_00053 Mycobacterium leprae Br4923 hypothetical protein YP_002502797.1 65182 R 561304 CDS YP_002502798.1 221229382 7325800 complement(67413..68858) 1 NC_011896.1 hypothetical protein 68858 7325800 MLBr_00054 Mycobacterium leprae Br4923 hypothetical protein YP_002502798.1 67413 R 561304 CDS YP_002502799.1 221229383 7325801 complement(68862..70583) 1 NC_011896.1 hypothetical protein 70583 7325801 MLBr_00055 Mycobacterium leprae Br4923 hypothetical protein YP_002502799.1 68862 R 561304 CDS YP_002502800.1 221229384 7325802 complement(70580..71089) 1 NC_011896.1 hypothetical protein 71089 7325802 MLBr_00056 Mycobacterium leprae Br4923 hypothetical protein YP_002502800.1 70580 R 561304 CDS YP_002502801.1 221229385 7325807 77736..82319 1 NC_011896.1 ferredoxin-dependent glutamate synthase 82319 gltB 7325807 gltB Mycobacterium leprae Br4923 ferredoxin-dependent glutamate synthase YP_002502801.1 77736 D 561304 CDS YP_002502802.1 221229386 7325366 82312..83778 1 NC_011896.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 83778 gltD 7325366 gltD Mycobacterium leprae Br4923 glutamate synthase subunit beta YP_002502802.1 82312 D 561304 CDS YP_002502803.1 221229387 7325808 complement(85995..86639) 1 NC_011896.1 transcriptional regulator 86639 7325808 MLBr_00064 Mycobacterium leprae Br4923 transcriptional regulator YP_002502803.1 85995 R 561304 CDS YP_002502804.1 221229388 7325809 86708..88192 1 NC_011896.1 monooxygenase 88192 7325809 MLBr_00065 Mycobacterium leprae Br4923 monooxygenase YP_002502804.1 86708 D 561304 CDS YP_002502805.1 221229389 7325810 complement(88273..88746) 1 NC_011896.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 88746 menG 7325810 menG Mycobacterium leprae Br4923 ribonuclease activity regulator protein RraA YP_002502805.1 88273 R 561304 CDS YP_002502806.1 221229390 7325450 complement(88768..89133) 1 NC_011896.1 histone-like protein 89133 hns 7325450 hns Mycobacterium leprae Br4923 histone-like protein YP_002502806.1 88768 R 561304 CDS YP_002502807.1 221229391 7324690 complement(89647..90363) 1 NC_011896.1 hypothetical protein 90363 7324690 MLBr_00068 Mycobacterium leprae Br4923 hypothetical protein YP_002502807.1 89647 R 561304 CDS YP_002502808.1 221229392 7325811 complement(90548..90946) 1 NC_011896.1 hypothetical protein 90946 7325811 MLBr_00069 Mycobacterium leprae Br4923 hypothetical protein YP_002502808.1 90548 R 561304 CDS YP_002502809.1 221229393 7325812 complement(91323..91586) 1 NC_011896.1 hypothetical protein 91586 7325812 MLBr_00070 Mycobacterium leprae Br4923 hypothetical protein YP_002502809.1 91323 R 561304 CDS YP_002502810.1 221229394 7325813 complement(91940..92473) 1 NC_011896.1 hypothetical protein 92473 7325813 MLBr_00071 Mycobacterium leprae Br4923 hypothetical protein YP_002502810.1 91940 R 561304 CDS YP_002502811.1 221229395 7325814 complement(92674..93297) 1 NC_011896.1 superoxide dismutase 93297 sodA 7325814 sodA Mycobacterium leprae Br4923 superoxide dismutase YP_002502811.1 92674 R 561304 CDS YP_002502812.1 221229396 7325997 94119..95153 1 NC_011896.1 hypothetical protein 95153 7325997 MLBr_00073 Mycobacterium leprae Br4923 hypothetical protein YP_002502812.1 94119 D 561304 CDS YP_002502813.1 221229397 7325815 95159..95974 1 NC_011896.1 glycerophosphoryl diester phosphodiesterase 95974 glpQ 7325815 glpQ Mycobacterium leprae Br4923 glycerophosphoryl diester phosphodiesterase YP_002502813.1 95159 D 561304 CDS YP_002502814.1 221229398 7325817 98452..99420 1 NC_011896.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 99420 pheA 7325817 pheA Mycobacterium leprae Br4923 prephenate dehydratase YP_002502814.1 98452 D 561304 CDS YP_002502815.1 221229399 7327388 99417..100112 1 NC_011896.1 phosphoglycerate mutase 100112 7327388 MLBr_00079 Mycobacterium leprae Br4923 phosphoglycerate mutase YP_002502815.1 99417 D 561304 CDS YP_002502816.1 221229400 7325819 complement(100675..102027) 1 NC_011896.1 hypothetical protein 102027 7325819 MLBr_00081 Mycobacterium leprae Br4923 hypothetical protein YP_002502816.1 100675 R 561304 CDS YP_002502817.1 221229401 7325820 102149..103402 1 NC_011896.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 103402 serS 7325820 serS Mycobacterium leprae Br4923 seryl-tRNA synthetase YP_002502817.1 102149 D 561304 CDS YP_002502818.1 221229402 7325824 109076..109849 1 NC_011896.1 acyltransferase 109849 7325824 MLBr_00087 Mycobacterium leprae Br4923 acyltransferase YP_002502818.1 109076 D 561304 CDS YP_002502819.1 221229403 7325826 110356..111201 1 NC_011896.1 hypothetical protein 111201 7325826 MLBr_00089 Mycobacterium leprae Br4923 hypothetical protein YP_002502819.1 110356 D 561304 CDS YP_002502820.1 221229404 7326129 complement(113180..113890) 1 NC_011896.1 hypothetical protein 113890 7326129 MLBr_00091 Mycobacterium leprae Br4923 hypothetical protein YP_002502820.1 113180 R 561304 CDS YP_002502821.1 221229405 7325828 114157..115398 1 NC_011896.1 UDP-galactopyranose mutase 115398 glf 7325828 glf Mycobacterium leprae Br4923 UDP-galactopyranose mutase YP_002502821.1 114157 D 561304 CDS YP_002502822.1 221229406 7325343 115398..117329 1 NC_011896.1 hypothetical protein 117329 7325343 MLBr_00093 Mycobacterium leprae Br4923 hypothetical protein YP_002502822.1 115398 D 561304 CDS YP_002502823.1 221229407 7325829 117322..117900 1 NC_011896.1 hypothetical protein 117900 7325829 MLBr_00094 Mycobacterium leprae Br4923 hypothetical protein YP_002502823.1 117322 D 561304 CDS YP_002502824.1 221229408 7325830 117897..118805 1 NC_011896.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 118805 7325830 MLBr_00095 Mycobacterium leprae Br4923 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase YP_002502824.1 117897 D 561304 CDS YP_002502825.1 221229409 7325831 118846..120795 1 NC_011896.1 hypothetical protein 120795 7325831 MLBr_00096 Mycobacterium leprae Br4923 hypothetical protein YP_002502825.1 118846 D 561304 CDS YP_002502826.1 221229410 7325832 121184..122176 1 NC_011896.1 antigen 85A, mycolytransferase 122176 fbpA 7325832 fbpA Mycobacterium leprae Br4923 antigen 85A, mycolytransferase YP_002502826.1 121184 D 561304 CDS YP_002502827.1 221229411 7325288 122337..123242 1 NC_011896.1 antigen 85C, mycolyltransferase 123242 fbpC 7325288 fbpC Mycobacterium leprae Br4923 antigen 85C, mycolyltransferase YP_002502827.1 122337 D 561304 CDS YP_002502828.1 221229412 7325290 123397..124407 1 NC_011896.1 hypothetical protein 124407 7325290 MLBr_00099 Mycobacterium leprae Br4923 hypothetical protein YP_002502828.1 123397 D 561304 CDS YP_002502829.1 221229413 7325833 124626..126533 1 NC_011896.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 126533 fadD32 7325833 fadD32 Mycobacterium leprae Br4923 long-chain-fatty-acid--CoA ligase YP_002502829.1 124626 D 561304 CDS YP_002502830.1 221229414 7325255 126545..131899 1 NC_011896.1 polyketide synthase 131899 pks13 7325255 pks13 Mycobacterium leprae Br4923 polyketide synthase YP_002502830.1 126545 D 561304 CDS YP_002502831.1 221229415 7327412 131896..133449 1 NC_011896.1 acyl CoA carboxylase beta subunit 133449 accD4 7327412 accD4 Mycobacterium leprae Br4923 acyl CoA carboxylase beta subunit YP_002502831.1 131896 D 561304 CDS YP_002502832.1 221229416 7325277 complement(136600..139851) 1 NC_011896.1 arabinosyltransferase 139851 embB 7325277 embB Mycobacterium leprae Br4923 arabinosyltransferase YP_002502832.1 136600 R 561304 CDS YP_002502833.1 221229417 7325225 complement(139848..143183) 1 NC_011896.1 arabinosyltransferase 143183 embA 7325225 embA Mycobacterium leprae Br4923 arabinosyltransferase YP_002502833.1 139848 R 561304 CDS YP_002502834.1 221229418 7325224 complement(144142..147354) 1 NC_011896.1 arabinosyltransferase 147354 embC 7325224 embC Mycobacterium leprae Br4923 arabinosyltransferase YP_002502834.1 144142 R 561304 CDS YP_002502835.1 221229419 7325226 complement(147487..149385) 1 NC_011896.1 hypothetical protein 149385 7325226 MLBr_00107 Mycobacterium leprae Br4923 hypothetical protein YP_002502835.1 147487 R 561304 CDS YP_002502836.1 221229420 7325834 complement(149388..150152) 1 NC_011896.1 short chain dehydrogenase 150152 7325834 MLBr_00108 Mycobacterium leprae Br4923 short chain dehydrogenase YP_002502836.1 149388 R 561304 CDS YP_002502837.1 221229421 7325835 complement(150155..151537) 1 NC_011896.1 FAD-linked oxidoreductase 151537 7325835 MLBr_00109 Mycobacterium leprae Br4923 FAD-linked oxidoreductase YP_002502837.1 150155 R 561304 CDS YP_002502838.1 221229422 7325836 complement(151605..151976) 1 NC_011896.1 hypothetical protein 151976 7325836 MLBr_00110 Mycobacterium leprae Br4923 hypothetical protein YP_002502838.1 151605 R 561304 CDS YP_002502839.1 221229423 7325838 complement(152810..153640) 1 NC_011896.1 ABC transporter 153640 7325838 MLBr_00112 Mycobacterium leprae Br4923 ABC transporter YP_002502839.1 152810 R 561304 CDS YP_002502840.1 221229424 7325839 complement(153690..154541) 1 NC_011896.1 glycosyl transferase family protein 154541 rfbE 7325839 rfbE Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002502840.1 153690 R 561304 CDS YP_002502841.1 221229425 7326617 complement(154603..155421) 1 NC_011896.1 ABC transporter ATP-binding protein 155421 7326617 MLBr_00114 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002502841.1 154603 R 561304 CDS YP_002502842.1 221229426 7325840 complement(155440..155964) 1 NC_011896.1 hypothetical protein 155964 7325840 MLBr_00115 Mycobacterium leprae Br4923 hypothetical protein YP_002502842.1 155440 R 561304 CDS YP_002502843.1 221229427 7325841 complement(155992..157956) 1 NC_011896.1 hypothetical protein 157956 7325841 MLBr_00116 Mycobacterium leprae Br4923 hypothetical protein YP_002502843.1 155992 R 561304 CDS YP_002502844.1 221229428 7325842 158083..159279 1 NC_011896.1 hypothetical protein 159279 7325842 MLBr_00117 Mycobacterium leprae Br4923 hypothetical protein YP_002502844.1 158083 D 561304 CDS YP_002502845.1 221229429 7325843 complement(159276..160286) 1 NC_011896.1 oxidireductase 160286 7325843 MLBr_00118 Mycobacterium leprae Br4923 oxidireductase YP_002502845.1 159276 R 561304 CDS YP_002502846.1 221229430 7325983 complement(160522..161757) 1 NC_011896.1 hydrolase 161757 lipE 7325983 lipE Mycobacterium leprae Br4923 hydrolase YP_002502846.1 160522 R 561304 CDS YP_002502847.1 221229431 7325390 complement(161768..162604) 1 NC_011896.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 162604 echA1 7325390 echA1 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002502847.1 161768 R 561304 CDS YP_002502848.1 221229432 7326190 complement(163797..164066) 1 NC_011896.1 hypothetical protein 164066 7326190 MLBr_00121 Mycobacterium leprae Br4923 hypothetical protein YP_002502848.1 163797 R 561304 CDS YP_002502849.1 221229433 7325846 complement(166976..167416) 1 NC_011896.1 hypothetical protein 167416 7325846 MLBr_00124 Mycobacterium leprae Br4923 hypothetical protein YP_002502849.1 166976 R 561304 CDS YP_002502850.1 221229434 7325847 167625..168941 1 NC_011896.1 glycosyl transferase family protein 168941 7325847 MLBr_00125 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002502850.1 167625 D 561304 CDS YP_002502851.1 221229435 7325848 169612..170433 1 NC_011896.1 hypothetical protein 170433 7325848 MLBr_00126 Mycobacterium leprae Br4923 hypothetical protein YP_002502851.1 169612 D 561304 CDS YP_002502852.1 221229436 7325849 170689..171378 1 NC_011896.1 hypothetical protein 171378 7325849 MLBr_00127 Mycobacterium leprae Br4923 hypothetical protein YP_002502852.1 170689 D 561304 CDS YP_002502853.1 221229437 7325850 171643..172950 1 NC_011896.1 glycosyl transferase family protein 172950 7325850 MLBr_00128 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002502853.1 171643 D 561304 CDS YP_002502854.1 221229438 7325851 complement(173197..174453) 1 NC_011896.1 hypothetical protein 174453 7325851 MLBr_00129 Mycobacterium leprae Br4923 hypothetical protein YP_002502854.1 173197 R 561304 CDS YP_002502855.1 221229439 7325852 complement(174493..175305) 1 NC_011896.1 hypothetical protein 175305 7325852 MLBr_00130 Mycobacterium leprae Br4923 hypothetical protein YP_002502855.1 174493 R 561304 CDS YP_002502856.1 221229440 7325853 175468..176616 1 NC_011896.1 oxidoreductase 176616 7325853 MLBr_00131 Mycobacterium leprae Br4923 oxidoreductase YP_002502856.1 175468 D 561304 CDS YP_002502857.1 221229441 7325854 177197..179239 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 179239 fadD29 7325854 fadD29 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002502857.1 177197 D 561304 CDS YP_002502858.1 221229442 7325252 179283..179915 1 NC_011896.1 hypothetical protein 179915 7325252 MLBr_00133 Mycobacterium leprae Br4923 hypothetical protein YP_002502858.1 179283 D 561304 CDS YP_002502859.1 221229443 7325855 180054..182177 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 182177 fadD22 7325855 fadD22 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002502859.1 180054 D 561304 CDS YP_002502860.1 221229444 7325248 182200..188511 1 NC_011896.1 polyketide synthase 188511 7325248 MLBr_00135 Mycobacterium leprae Br4923 polyketide synthase YP_002502860.1 182200 D 561304 CDS YP_002502861.1 221229445 7325856 188578..189279 1 NC_011896.1 lipoprotein 189279 lppX 7325856 lppX Mycobacterium leprae Br4923 lipoprotein YP_002502861.1 188578 D 561304 CDS YP_002502862.1 221229446 7325413 complement(189280..191988) 1 NC_011896.1 hypothetical protein 191988 mmpL7 7325413 mmpL7 Mycobacterium leprae Br4923 hypothetical protein YP_002502862.1 189280 R 561304 CDS YP_002502863.1 221229447 7324907 complement(192040..193779) 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 193779 fadD28 7324907 fadD28 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002502863.1 192040 R 561304 CDS YP_002502864.1 221229448 7325251 194248..200598 1 NC_011896.1 mycocerosic synthase 200598 mas 7325251 mas Mycobacterium leprae Br4923 mycocerosic synthase YP_002502864.1 194248 D 561304 CDS YP_002502865.1 221229449 7325857 complement(202334..202588) 1 NC_011896.1 hypothetical protein 202588 7325857 MLBr_00141 Mycobacterium leprae Br4923 hypothetical protein YP_002502865.1 202334 R 561304 CDS YP_002502866.1 221229450 7325858 204390..204638 1 NC_011896.1 hypothetical protein 204638 7325858 MLBr_00142 Mycobacterium leprae Br4923 hypothetical protein YP_002502866.1 204390 D 561304 CDS YP_002502867.1 221229451 7325866 complement(211177..212841) 1 NC_011896.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 212841 pgi 7325866 pgi Mycobacterium leprae Br4923 glucose-6-phosphate isomerase YP_002502867.1 211177 R 561304 CDS YP_002502868.1 221229452 7327382 complement(213202..213519) 1 NC_011896.1 hypothetical protein 213519 7327382 MLBr_00151 Mycobacterium leprae Br4923 hypothetical protein YP_002502868.1 213202 R 561304 CDS YP_002502869.1 221229453 7326275 214028..214216 1 NC_011896.1 hypothetical protein 214216 7326275 MLBr_00152 Mycobacterium leprae Br4923 hypothetical protein YP_002502869.1 214028 D 561304 CDS YP_002502870.1 221229454 7326276 214299..216635 1 NC_011896.1 ATP-dependent DNA helicase 216635 uvrD 7326276 uvrD Mycobacterium leprae Br4923 ATP-dependent DNA helicase YP_002502870.1 214299 D 561304 CDS YP_002502871.1 221229455 7327308 complement(217187..218188) 1 NC_011896.1 hypothetical protein 218188 7327308 MLBr_00154 Mycobacterium leprae Br4923 hypothetical protein YP_002502871.1 217187 R 561304 CDS YP_002502872.1 221229456 7326277 218485..219666 1 NC_011896.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 219666 sucC 7326277 sucC Mycobacterium leprae Br4923 succinyl-CoA synthetase subunit beta YP_002502872.1 218485 D 561304 CDS YP_002502873.1 221229457 7326005 219686..220588 1 NC_011896.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 220588 sucD 7326005 sucD Mycobacterium leprae Br4923 succinyl-CoA synthetase subunit alpha YP_002502873.1 219686 D 561304 CDS YP_002502874.1 221229458 7326278 221684..222628 1 NC_011896.1 hypothetical protein 222628 7326278 MLBr_00158 Mycobacterium leprae Br4923 hypothetical protein YP_002502874.1 221684 D 561304 CDS YP_002502875.1 221229459 7326279 222677..223969 1 NC_011896.1 hypothetical protein 223969 7326279 MLBr_00159 Mycobacterium leprae Br4923 hypothetical protein YP_002502875.1 222677 D 561304 CDS YP_002502876.1 221229460 7326280 223999..224646 1 NC_011896.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 224646 purN 7326280 purN Mycobacterium leprae Br4923 phosphoribosylglycinamide formyltransferase YP_002502876.1 223999 D 561304 CDS YP_002502877.1 221229461 7325042 224643..226226 1 NC_011896.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 226226 purH 7325042 purH Mycobacterium leprae Br4923 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002502877.1 224643 D 561304 CDS YP_002502878.1 221229462 7325038 complement(227035..227313) 1 NC_011896.1 hypothetical protein 227313 7325038 MLBr_00162 Mycobacterium leprae Br4923 hypothetical protein YP_002502878.1 227035 R 561304 CDS YP_002502879.1 221229463 7325220 234947..235549 1 NC_011896.1 hypothetical protein 235549 7325220 MLBr_00169 Mycobacterium leprae Br4923 hypothetical protein YP_002502879.1 234947 D 561304 CDS YP_002502880.1 221229464 7326286 240252..240425 1 NC_011896.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 240425 rpmF 7326286 rpmF Mycobacterium leprae Br4923 50S ribosomal protein L32 YP_002502880.1 240252 D 561304 CDS YP_002502881.1 221229465 7326669 240546..241232 1 NC_011896.1 two-component response regulator 241232 7326669 MLBr_00174 Mycobacterium leprae Br4923 two-component response regulator YP_002502881.1 240546 D 561304 CDS YP_002502882.1 221229466 7326287 241232..242791 1 NC_011896.1 two-component system sensor kinase 242791 7326287 MLBr_00175 Mycobacterium leprae Br4923 two-component system sensor kinase YP_002502882.1 241232 D 561304 CDS YP_002502883.1 221229467 7326288 243069..244217 1 NC_011896.1 serine protease 244217 7326288 MLBr_00176 Mycobacterium leprae Br4923 serine protease YP_002502883.1 243069 D 561304 CDS YP_002502884.1 221229468 7326289 244240..244785 1 NC_011896.1 molybdenum cofactor biosynthesis protein 244785 moaB 7326289 moaB Mycobacterium leprae Br4923 molybdenum cofactor biosynthesis protein YP_002502884.1 244240 D 561304 CDS YP_002502885.1 221229469 7324912 complement(244802..245266) 1 NC_011896.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 245266 mscL 7324912 mscL Mycobacterium leprae Br4923 large-conductance mechanosensitive channel YP_002502885.1 244802 R 561304 CDS YP_002502886.1 221229470 7326290 complement(246064..246363) 1 NC_011896.1 hypothetical protein 246363 7326290 MLBr_00180 Mycobacterium leprae Br4923 hypothetical protein YP_002502886.1 246064 R 561304 CDS YP_002502887.1 221229471 7326291 complement(246438..247031) 1 NC_011896.1 hypothetical protein 247031 7326291 MLBr_00181 Mycobacterium leprae Br4923 hypothetical protein YP_002502887.1 246438 R 561304 CDS YP_002502888.1 221229472 7326292 247109..248029 1 NC_011896.1 UTP-glucose-1-phosphate uridylyltransferase 248029 galU 7326292 galU Mycobacterium leprae Br4923 UTP-glucose-1-phosphate uridylyltransferase YP_002502888.1 247109 D 561304 CDS YP_002502889.1 221229473 7325329 248117..249391 1 NC_011896.1 molybdopterin biosynthesis protein 249391 moeA 7325329 moeA Mycobacterium leprae Br4923 molybdopterin biosynthesis protein YP_002502889.1 248117 D 561304 CDS YP_002502890.1 221229474 7324920 249422..250066 1 NC_011896.1 acetyltransferase 250066 rimJ 7324920 rimJ Mycobacterium leprae Br4923 acetyltransferase YP_002502890.1 249422 D 561304 CDS YP_002502891.1 221229475 7326625 250236..251264 1 NC_011896.1 hypothetical protein 251264 7326625 MLBr_00185 Mycobacterium leprae Br4923 hypothetical protein YP_002502891.1 250236 D 561304 CDS YP_002502892.1 221229476 7326294 252673..253734 1 NC_011896.1 hypothetical protein 253734 7326294 MLBr_00187 Mycobacterium leprae Br4923 hypothetical protein YP_002502892.1 252673 D 561304 CDS YP_002502893.1 221229477 7326295 254043..254306 1 NC_011896.1 hypothetical protein 254306 7326295 MLBr_00188 Mycobacterium leprae Br4923 hypothetical protein YP_002502893.1 254043 D 561304 CDS YP_002502894.1 221229478 7326297 complement(255140..255757) 1 NC_011896.1 hypothetical protein 255757 7326297 MLBr_00190 Mycobacterium leprae Br4923 hypothetical protein YP_002502894.1 255140 R 561304 CDS YP_002502895.1 221229479 7327216 complement(257050..258582) 1 NC_011896.1 hypothetical protein 258582 7327216 MLBr_00192 Mycobacterium leprae Br4923 hypothetical protein YP_002502895.1 257050 R 561304 CDS YP_002502896.1 221229480 7326299 258661..259506 1 NC_011896.1 hypothetical protein 259506 7326299 MLBr_00193 Mycobacterium leprae Br4923 hypothetical protein YP_002502896.1 258661 D 561304 CDS YP_002502897.1 221229481 7326302 264913..265116 1 NC_011896.1 cold shock protein 265116 cspA 7326302 cspA Mycobacterium leprae Br4923 cold shock protein YP_002502897.1 264913 D 561304 CDS YP_002502898.1 221229482 7326130 265228..265830 1 NC_011896.1 hypothetical protein 265830 7326130 MLBr_00199 Mycobacterium leprae Br4923 hypothetical protein YP_002502898.1 265228 D 561304 CDS YP_002502899.1 221229483 7326303 266048..268891 1 NC_011896.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 268891 topA 7326303 topA Mycobacterium leprae Br4923 DNA topoisomerase I YP_002502899.1 266048 D 561304 CDS YP_002502900.1 221229484 7326029 complement(268872..270464) 1 NC_011896.1 hypothetical protein 270464 7326029 MLBr_00201 Mycobacterium leprae Br4923 hypothetical protein YP_002502900.1 268872 R 561304 CDS YP_002502901.1 221229485 7326304 270620..271837 1 NC_011896.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 271837 7326304 MLBr_00202 Mycobacterium leprae Br4923 DNA polymerase III subunit delta' YP_002502901.1 270620 D 561304 CDS YP_002502902.1 221229486 7326023 complement(273305..275014) 1 NC_011896.1 hypothetical protein 275014 7326023 MLBr_00203 Mycobacterium leprae Br4923 hypothetical protein YP_002502902.1 273305 R 561304 CDS YP_002502903.1 221229487 7326306 275064..276023 1 NC_011896.1 sugar-nucleotide dehydratase 276023 rmlB2 7326306 rmlB2 Mycobacterium leprae Br4923 sugar-nucleotide dehydratase YP_002502903.1 275064 D 561304 CDS YP_002502904.1 221229488 7326629 complement(276722..277792) 1 NC_011896.1 hypothetical protein 277792 7326629 MLBr_00205 Mycobacterium leprae Br4923 hypothetical protein YP_002502904.1 276722 R 561304 CDS YP_002502905.1 221229489 7326308 279066..279785 1 NC_011896.1 glycosyltransferase 279785 7326308 MLBr_00207 Mycobacterium leprae Br4923 glycosyltransferase YP_002502905.1 279066 D 561304 CDS YP_002502906.1 221229490 7326309 279799..280140 1 NC_011896.1 hypothetical protein 280140 7326309 MLBr_00208 Mycobacterium leprae Br4923 hypothetical protein YP_002502906.1 279799 D 561304 CDS YP_002502907.1 221229491 7326311 complement(281558..282046) 1 NC_011896.1 inorganic pyrophosphatase 282046 ppa 7326311 ppa Mycobacterium leprae Br4923 inorganic pyrophosphatase YP_002502907.1 281558 R 561304 CDS YP_002502908.1 221229492 7324983 282172..283557 1 NC_011896.1 carboxypeptidase 283557 7324983 MLBr_00211 Mycobacterium leprae Br4923 carboxypeptidase YP_002502908.1 282172 D 561304 CDS YP_002502909.1 221229493 7326313 284595..285566 1 NC_011896.1 hypothetical protein 285566 mesJ 7326313 mesJ Mycobacterium leprae Br4923 hypothetical protein YP_002502909.1 284595 D 561304 CDS YP_002502910.1 221229494 7325451 285599..286240 1 NC_011896.1 hypoxanthine phosphoribosyltransferase 286240 hpt 7325451 hpt Mycobacterium leprae Br4923 hypoxanthine phosphoribosyltransferase YP_002502910.1 285599 D 561304 CDS YP_002502911.1 221229495 7326315 288693..288938 1 NC_011896.1 hypothetical protein 288938 7326315 MLBr_00217 Mycobacterium leprae Br4923 hypothetical protein YP_002502911.1 288693 D 561304 CDS YP_002502912.1 221229496 7326316 complement(289844..290230) 1 NC_011896.1 hypothetical protein 290230 7326316 MLBr_00218 Mycobacterium leprae Br4923 hypothetical protein YP_002502912.1 289844 R 561304 CDS YP_002502913.1 221229497 7326320 293708..296080 1 NC_011896.1 integral membrane peptidase 296080 ftsH 7326320 ftsH Mycobacterium leprae Br4923 integral membrane peptidase YP_002502913.1 293708 D 561304 CDS YP_002502914.1 221229498 7325313 296097..296714 1 NC_011896.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 296714 folE 7325313 folE Mycobacterium leprae Br4923 GTP cyclohydrolase I YP_002502914.1 296097 D 561304 CDS YP_002502915.1 221229499 7325304 296711..297565 1 NC_011896.1 dihydropteroate synthase 297565 folP 7325304 folP Mycobacterium leprae Br4923 dihydropteroate synthase YP_002502915.1 296711 D 561304 CDS YP_002502916.1 221229500 7325306 297558..297956 1 NC_011896.1 dihydroneopterin aldolase 297956 folB 7325306 folB Mycobacterium leprae Br4923 dihydroneopterin aldolase YP_002502916.1 297558 D 561304 CDS YP_002502917.1 221229501 7325301 297956..298531 1 NC_011896.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 298531 folK 7325301 folK Mycobacterium leprae Br4923 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002502917.1 297956 D 561304 CDS YP_002502918.1 221229502 7325305 298531..299007 1 NC_011896.1 hypothetical protein 299007 7325305 MLBr_00227 Mycobacterium leprae Br4923 hypothetical protein YP_002502918.1 298531 D 561304 CDS YP_002502919.1 221229503 7326321 299153..300451 1 NC_011896.1 hypothetical protein 300451 7326321 MLBr_00228 Mycobacterium leprae Br4923 hypothetical protein YP_002502919.1 299153 D 561304 CDS YP_002502920.1 221229504 7326322 300552..301481 1 NC_011896.1 hypothetical protein 301481 7326322 MLBr_00229 Mycobacterium leprae Br4923 hypothetical protein YP_002502920.1 300552 D 561304 CDS YP_002502921.1 221229505 7326323 301478..302419 1 NC_011896.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 302419 panC 7326323 panC Mycobacterium leprae Br4923 pantoate--beta-alanine ligase YP_002502921.1 301478 D 561304 CDS YP_002502922.1 221229506 7327349 302419..302847 1 NC_011896.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 302847 panD 7327349 panD Mycobacterium leprae Br4923 aspartate alpha-decarboxylase YP_002502922.1 302419 D 561304 CDS YP_002502923.1 221229507 7327350 302850..303674 1 NC_011896.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 303674 7327350 MLBr_00232 Mycobacterium leprae Br4923 pantothenate kinase YP_002502923.1 302850 D 561304 CDS YP_002502924.1 221229508 7326324 303755..305278 1 NC_011896.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 305278 lysS 7326324 lysS Mycobacterium leprae Br4923 lysyl-tRNA synthetase YP_002502924.1 303755 D 561304 CDS YP_002502925.1 221229509 7325430 305383..305721 1 NC_011896.1 lsr2 protein (15 kDa antigen) 305721 lsr2 7325430 lsr2 Mycobacterium leprae Br4923 lsr2 protein (15 kDa antigen) YP_002502925.1 305383 D 561304 CDS YP_002502926.1 221229510 7325427 306018..308564 1 NC_011896.1 ATP-dependent Clp protease 308564 clpC 7325427 clpC Mycobacterium leprae Br4923 ATP-dependent Clp protease YP_002502926.1 306018 D 561304 CDS YP_002502927.1 221229511 7327274 complement(309670..310926) 1 NC_011896.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 310926 pabB 7327274 pabB Mycobacterium leprae Br4923 aminodeoxychorismate synthase component I YP_002502927.1 309670 R 561304 CDS YP_002502928.1 221229512 7326325 complement(312224..313837) 1 NC_011896.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 313837 metS 7326325 metS Mycobacterium leprae Br4923 methionyl-tRNA synthetase YP_002502928.1 312224 R 561304 CDS YP_002502929.1 221229513 7325458 313926..314714 1 NC_011896.1 hypothetical protein 314714 7325458 MLBr_00239 Mycobacterium leprae Br4923 hypothetical protein YP_002502929.1 313926 D 561304 CDS YP_002502930.1 221229514 7326326 314964..316091 1 NC_011896.1 hypothetical protein 316091 7326326 MLBr_00240 Mycobacterium leprae Br4923 hypothetical protein YP_002502930.1 314964 D 561304 CDS YP_002502931.1 221229515 7326327 316064..316984 1 NC_011896.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 316984 ksgA 7326327 ksgA Mycobacterium leprae Br4923 dimethyladenosine transferase YP_002502931.1 316064 D 561304 CDS YP_002502932.1 221229516 7324725 317058..317993 1 NC_011896.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 317993 7324725 MLBr_00242 Mycobacterium leprae Br4923 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002502932.1 317058 D 561304 CDS YP_002502933.1 221229517 7326328 318236..319870 1 NC_011896.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 319870 7326328 MLBr_00243 Mycobacterium leprae Br4923 long-chain-fatty-acid--CoA ligase YP_002502933.1 318236 D 561304 CDS YP_002502934.1 221229518 7326329 complement(319981..320580) 1 NC_011896.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 320580 pth 7326329 pth Mycobacterium leprae Br4923 peptidyl-tRNA hydrolase YP_002502934.1 319981 R 561304 CDS YP_002502935.1 221229519 7325029 complement(320593..321240) 1 NC_011896.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 321240 rplY 7325029 rplY Mycobacterium leprae Br4923 50S ribosomal protein L25 YP_002502935.1 320593 R 561304 CDS YP_002502936.1 221229520 7326663 complement(322415..323071) 1 NC_011896.1 lipoprotein 323071 lpqT 7326663 lpqT Mycobacterium leprae Br4923 lipoprotein YP_002502936.1 322415 R 561304 CDS YP_002502937.1 221229521 7325421 complement(323108..323422) 1 NC_011896.1 arsenate reductase 323422 arsC 7325421 arsC Mycobacterium leprae Br4923 arsenate reductase YP_002502937.1 323108 R 561304 CDS YP_002502938.1 221229522 7327238 complement(323478..324461) 1 NC_011896.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 324461 prsA 7327238 prsA Mycobacterium leprae Br4923 ribose-phosphate pyrophosphokinase YP_002502938.1 323478 R 561304 CDS YP_002502939.1 221229523 7325018 complement(324572..326050) 1 NC_011896.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 326050 glmU 7325018 glmU Mycobacterium leprae Br4923 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002502939.1 324572 R 561304 CDS YP_002502940.1 221229524 7326331 328083..331757 1 NC_011896.1 transcription-repair coupling factor 331757 mfd 7326331 mfd Mycobacterium leprae Br4923 transcription-repair coupling factor YP_002502940.1 328083 D 561304 CDS YP_002502941.1 221229525 7325422 333767..335110 1 NC_011896.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 335110 eno 7325422 eno Mycobacterium leprae Br4923 phosphopyruvate hydratase YP_002502941.1 333767 D 561304 CDS YP_002502942.1 221229526 7325227 335145..335828 1 NC_011896.1 hypothetical protein 335828 7325227 MLBr_00256 Mycobacterium leprae Br4923 hypothetical protein YP_002502942.1 335145 D 561304 CDS YP_002502943.1 221229527 7326333 335821..336324 1 NC_011896.1 hypothetical protein 336324 7326333 MLBr_00257 Mycobacterium leprae Br4923 hypothetical protein YP_002502943.1 335821 D 561304 CDS YP_002502944.1 221229528 7326334 336321..337274 1 NC_011896.1 hypothetical protein 337274 7326334 MLBr_00258 Mycobacterium leprae Br4923 hypothetical protein YP_002502944.1 336321 D 561304 CDS YP_002502945.1 221229529 7326340 345724..345936 1 NC_011896.1 hypothetical protein 345936 7326340 MLBr_00265 Mycobacterium leprae Br4923 hypothetical protein YP_002502945.1 345724 D 561304 CDS YP_002502946.1 221229530 7325028 complement(353023..354033) 1 NC_011896.1 F420-dependent glucose-6-phosphate dehydrogenase 354033 7325028 MLBr_00269 Mycobacterium leprae Br4923 F420-dependent glucose-6-phosphate dehydrogenase YP_002502946.1 353023 R 561304 CDS YP_002502947.1 221229531 7326343 354121..354876 1 NC_011896.1 hypothetical protein 354876 7326343 MLBr_00270 Mycobacterium leprae Br4923 hypothetical protein YP_002502947.1 354121 D 561304 CDS YP_002502948.1 221229532 7326344 complement(354865..355236) 1 NC_011896.1 hypothetical protein 355236 7326344 MLBr_00271 Mycobacterium leprae Br4923 hypothetical protein YP_002502948.1 354865 R 561304 CDS YP_002502949.1 221229533 7326347 complement(357573..358793) 1 NC_011896.1 O-succinylhomoserine sulfhydrylase 358793 metZ 7326347 metZ Mycobacterium leprae Br4923 O-succinylhomoserine sulfhydrylase YP_002502949.1 357573 R 561304 CDS YP_002502950.1 221229534 7324897 complement(358850..359293) 1 NC_011896.1 hypothetical protein 359293 7324897 MLBr_00276 Mycobacterium leprae Br4923 hypothetical protein YP_002502950.1 358850 R 561304 CDS YP_002502951.1 221229535 7326350 complement(361313..361969) 1 NC_011896.1 hypothetical protein 361969 7326350 MLBr_00279 Mycobacterium leprae Br4923 hypothetical protein YP_002502951.1 361313 R 561304 CDS YP_002502952.1 221229536 7326351 complement(361966..363264) 1 NC_011896.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 363264 purA 7326351 purA Mycobacterium leprae Br4923 adenylosuccinate synthetase YP_002502952.1 361966 R 561304 CDS YP_002502953.1 221229537 7325032 363448..364137 1 NC_011896.1 hypothetical protein 364137 7325032 MLBr_00281 Mycobacterium leprae Br4923 hypothetical protein YP_002502953.1 363448 D 561304 CDS YP_002502954.1 221229538 7326353 364932..365738 1 NC_011896.1 cation-efflux transporter component 365738 7326353 MLBr_00283 Mycobacterium leprae Br4923 cation-efflux transporter component YP_002502954.1 364932 D 561304 CDS YP_002502955.1 221229539 7326354 complement(365876..366289) 1 NC_011896.1 hypothetical protein 366289 7326354 MLBr_00284 Mycobacterium leprae Br4923 hypothetical protein YP_002502955.1 365876 R 561304 CDS YP_002502956.1 221229540 7326355 366401..367279 1 NC_011896.1 hypothetical protein 367279 7326355 MLBr_00285 Mycobacterium leprae Br4923 hypothetical protein YP_002502956.1 366401 D 561304 CDS YP_002502957.1 221229541 7326273 complement(367295..368332) 1 NC_011896.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 368332 fba 7326273 fba Mycobacterium leprae Br4923 fructose-bisphosphate aldolase YP_002502957.1 367295 R 561304 CDS YP_002502958.1 221229542 7325287 368465..369133 1 NC_011896.1 hypothetical protein 369133 7325287 MLBr_00287 Mycobacterium leprae Br4923 hypothetical protein YP_002502958.1 368465 D 561304 CDS YP_002502959.1 221229543 7326359 complement(372050..372442) 1 NC_011896.1 hypothetical protein 372442 7326359 MLBr_00291 Mycobacterium leprae Br4923 hypothetical protein YP_002502959.1 372050 R 561304 CDS YP_002502960.1 221229544 7326360 complement(373621..373860) 1 NC_011896.1 hypothetical protein 373860 7326360 MLBr_00292 Mycobacterium leprae Br4923 hypothetical protein YP_002502960.1 373621 R 561304 CDS YP_002502961.1 221229545 7326361 complement(375469..375678) 1 NC_011896.1 hypothetical protein 375678 7326361 MLBr_00293 Mycobacterium leprae Br4923 hypothetical protein YP_002502961.1 375469 R 561304 CDS YP_002502962.1 221229546 7326362 377503..379146 1 NC_011896.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 379146 thiC 7326362 thiC Mycobacterium leprae Br4923 thiamine biosynthesis protein ThiC YP_002502962.1 377503 D 561304 CDS YP_002502963.1 221229547 7326013 379143..379982 1 NC_011896.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 379982 thiD 7326013 thiD Mycobacterium leprae Br4923 phosphomethylpyrimidine kinase YP_002502963.1 379143 D 561304 CDS YP_002502964.1 221229548 7326363 complement(380661..381446) 1 NC_011896.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 381446 thiG 7326363 thiG Mycobacterium leprae Br4923 thiazole synthase YP_002502964.1 380661 R 561304 CDS YP_002502965.1 221229549 7326016 complement(381439..381663) 1 NC_011896.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 381663 7326016 MLBr_00298 Mycobacterium leprae Br4923 sulfur carrier protein ThiS YP_002502965.1 381439 R 561304 CDS YP_002502966.1 221229550 7326364 complement(381671..382693) 1 NC_011896.1 oxidoreductase 382693 7326364 MLBr_00299 Mycobacterium leprae Br4923 oxidoreductase YP_002502966.1 381671 R 561304 CDS YP_002502967.1 221229551 7326365 382851..383558 1 NC_011896.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 383558 thiE 7326365 thiE Mycobacterium leprae Br4923 thiamine-phosphate pyrophosphorylase YP_002502967.1 382851 D 561304 CDS YP_002502968.1 221229552 7326366 385666..386646 1 NC_011896.1 glutamine-binding protein 386646 glnH 7326366 glnH Mycobacterium leprae Br4923 glutamine-binding protein YP_002502968.1 385666 D 561304 CDS YP_002502969.1 221229553 7325356 386646..388949 1 NC_011896.1 serine-threonine protein kinase 388949 pknG 7325356 pknG Mycobacterium leprae Br4923 serine-threonine protein kinase YP_002502969.1 386646 D 561304 CDS YP_002502970.1 221229554 7326369 394474..395178 1 NC_011896.1 hypothetical protein 395178 7326369 MLBr_00308 Mycobacterium leprae Br4923 hypothetical protein YP_002502970.1 394474 D 561304 CDS YP_002502971.1 221229555 7326371 complement(397063..397965) 1 NC_011896.1 CDP-diacylglycerol-serine o-phosphatidyltransferase 397965 pssA 7326371 pssA Mycobacterium leprae Br4923 CDP-diacylglycerol-serine o-phosphatidyltransferase YP_002502971.1 397063 R 561304 CDS YP_002502972.1 221229556 7325019 complement(397962..398693) 1 NC_011896.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 398693 7325019 MLBr_00311 Mycobacterium leprae Br4923 phosphatidylserine decarboxylase YP_002502972.1 397962 R 561304 CDS YP_002502973.1 221229557 7326373 complement(400788..401795) 1 NC_011896.1 esterase 401795 7326373 MLBr_00314 Mycobacterium leprae Br4923 esterase YP_002502973.1 400788 R 561304 CDS YP_002502974.1 221229558 7326374 complement(403715..404629) 1 NC_011896.1 short chain dehydrogenase 404629 7326374 MLBr_00315 Mycobacterium leprae Br4923 short chain dehydrogenase YP_002502974.1 403715 R 561304 CDS YP_002502975.1 221229559 7326375 404724..405326 1 NC_011896.1 TetR family transcriptional regulator 405326 7326375 MLBr_00316 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002502975.1 404724 D 561304 CDS YP_002502976.1 221229560 7326376 405535..407160 1 NC_011896.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 407160 groEL 7326376 groEL Mycobacterium leprae Br4923 molecular chaperone GroEL YP_002502976.1 405535 D 561304 CDS YP_002502977.1 221229561 7326607 complement(409451..410002) 1 NC_011896.1 lipoprotein 410002 lpqE 7326607 lpqE Mycobacterium leprae Br4923 lipoprotein YP_002502977.1 409451 R 561304 CDS YP_002502978.1 221229562 7325417 410363..410860 1 NC_011896.1 transcription factor 410860 7325417 MLBr_00320 Mycobacterium leprae Br4923 transcription factor YP_002502978.1 410363 D 561304 CDS YP_002502979.1 221229563 7326377 410879..411604 1 NC_011896.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 411604 ispD 7326377 ispD Mycobacterium leprae Br4923 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002502979.1 410879 D 561304 CDS YP_002502980.1 221229564 7326378 411601..412077 1 NC_011896.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 412077 ispF 7326378 ispF Mycobacterium leprae Br4923 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002502980.1 411601 D 561304 CDS YP_002502981.1 221229565 7326379 412132..413553 1 NC_011896.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 413553 cysS 7326379 cysS Mycobacterium leprae Br4923 cysteinyl-tRNA synthetase YP_002502981.1 412132 D 561304 CDS YP_002502982.1 221229566 7326153 413636..414472 1 NC_011896.1 methyltransferase 414472 7326153 MLBr_00324 Mycobacterium leprae Br4923 methyltransferase YP_002502982.1 413636 D 561304 CDS YP_002502983.1 221229567 7326380 414874..415137 1 NC_011896.1 hypothetical protein 415137 7326380 MLBr_00325 Mycobacterium leprae Br4923 hypothetical protein YP_002502983.1 414874 D 561304 CDS YP_002502984.1 221229568 7326386 complement(423187..423945) 1 NC_011896.1 LamB/YcsF family protein 423945 7326386 MLBr_00333 Mycobacterium leprae Br4923 LamB/YcsF family protein YP_002502984.1 423187 R 561304 CDS YP_002502985.1 221229569 7327408 complement(424876..425736) 1 NC_011896.1 ABC-transporter transmembrane protein 425736 7327408 MLBr_00335 Mycobacterium leprae Br4923 ABC-transporter transmembrane protein YP_002502985.1 424876 R 561304 CDS YP_002502986.1 221229570 7326388 complement(425736..426563) 1 NC_011896.1 ABC-transporter ATP-binding protein 426563 7326388 MLBr_00336 Mycobacterium leprae Br4923 ABC-transporter ATP-binding protein YP_002502986.1 425736 R 561304 CDS YP_002502987.1 221229571 7326389 complement(426572..427480) 1 NC_011896.1 periplasmic solute-binding proteins 427480 7326389 MLBr_00337 Mycobacterium leprae Br4923 periplasmic solute-binding proteins YP_002502987.1 426572 R 561304 CDS YP_002502988.1 221229572 7326399 438271..439323 1 NC_011896.1 coenzyme F420-dependent oxidoreductase 439323 7326399 MLBr_00348 Mycobacterium leprae Br4923 coenzyme F420-dependent oxidoreductase YP_002502988.1 438271 D 561304 CDS YP_002502989.1 221229573 7326403 447423..448970 1 NC_011896.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 448970 ilvX 7326403 ilvX Mycobacterium leprae Br4923 hypothetical protein YP_002502989.1 447423 D 561304 CDS YP_002502990.1 221229574 7325445 456427..456741 1 NC_011896.1 hypothetical protein 456741 7325445 MLBr_00363 Mycobacterium leprae Br4923 hypothetical protein YP_002502990.1 456427 D 561304 CDS YP_002502991.1 221229575 7326408 456993..457436 1 NC_011896.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 457436 rplM 7326408 rplM Mycobacterium leprae Br4923 50S ribosomal protein L13 YP_002502991.1 456993 D 561304 CDS YP_002502992.1 221229576 7326651 457433..457894 1 NC_011896.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 457894 rpsI 7326651 rpsI Mycobacterium leprae Br4923 30S ribosomal protein S9 YP_002502992.1 457433 D 561304 CDS YP_002502993.1 221229577 7325949 458001..459392 1 NC_011896.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 459392 glmM 7325949 glmM Mycobacterium leprae Br4923 phosphoglucosamine mutase YP_002502993.1 458001 D 561304 CDS YP_002502994.1 221229578 7326410 complement(461194..461550) 1 NC_011896.1 hypothetical protein 461550 7326410 MLBr_00369 Mycobacterium leprae Br4923 hypothetical protein YP_002502994.1 461194 R 561304 CDS YP_002502995.1 221229579 7326411 complement(461954..462823) 1 NC_011896.1 hypothetical protein 462823 7326411 MLBr_00370 Mycobacterium leprae Br4923 hypothetical protein YP_002502995.1 461954 R 561304 CDS YP_002502996.1 221229580 7326412 462988..464865 1 NC_011896.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 464865 glmS 7326412 glmS Mycobacterium leprae Br4923 glucosamine--fructose-6-phosphate aminotransferase YP_002502996.1 462988 D 561304 CDS YP_002502997.1 221229581 7326413 465211..466632 1 NC_011896.1 hypothetical protein 466632 7326413 MLBr_00373 Mycobacterium leprae Br4923 hypothetical protein YP_002502997.1 465211 D 561304 CDS YP_002502998.1 221229582 7325327 468141..469307 1 NC_011896.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 469307 alr 7325327 alr Mycobacterium leprae Br4923 alanine racemase YP_002502998.1 468141 D 561304 CDS YP_002502999.1 221229583 7327205 469297..470298 1 NC_011896.1 hypothetical protein 470298 7327205 MLBr_00376 Mycobacterium leprae Br4923 hypothetical protein YP_002502999.1 469297 D 561304 CDS YP_002503000.1 221229584 7326415 470291..470776 1 NC_011896.1 hypothetical protein 470776 7326415 MLBr_00377 Mycobacterium leprae Br4923 hypothetical protein YP_002503000.1 470291 D 561304 CDS YP_002503001.1 221229585 7326416 470773..471852 1 NC_011896.1 acetyltransferase 471852 7326416 MLBr_00378 Mycobacterium leprae Br4923 acetyltransferase YP_002503001.1 470773 D 561304 CDS YP_002503002.1 221229586 7326417 471849..472904 1 NC_011896.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 472904 gcp 7326417 gcp Mycobacterium leprae Br4923 DNA-binding/iron metalloprotein/AP endonuclease YP_002503002.1 471849 D 561304 CDS YP_002503003.1 221229587 7325334 473186..473488 1 NC_011896.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 473488 groES 7325334 groES Mycobacterium leprae Br4923 co-chaperonin GroES YP_002503003.1 473186 D 561304 CDS YP_002503004.1 221229588 7324660 473567..475180 1 NC_011896.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 475180 groEL 7324660 groEL Mycobacterium leprae Br4923 molecular chaperone GroEL YP_002503004.1 473567 D 561304 CDS YP_002503005.1 221229589 7324658 complement(475780..476088) 1 NC_011896.1 transcriptional regulator 476088 whiB3 7324658 whiB3 Mycobacterium leprae Br4923 transcriptional regulator YP_002503005.1 475780 R 561304 CDS YP_002503006.1 221229590 7327317 476449..477294 1 NC_011896.1 hypothetical protein 477294 7327317 MLBr_00383 Mycobacterium leprae Br4923 hypothetical protein YP_002503006.1 476449 D 561304 CDS YP_002503007.1 221229591 7326419 complement(480102..480515) 1 NC_011896.1 hypothetical protein 480515 7326419 MLBr_00386 Mycobacterium leprae Br4923 hypothetical protein YP_002503007.1 480102 R 561304 CDS YP_002503008.1 221229592 7326420 480670..482259 1 NC_011896.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 482259 guaB2 7326420 guaB2 Mycobacterium leprae Br4923 inosine 5'-monophosphate dehydrogenase YP_002503008.1 480670 D 561304 CDS YP_002503009.1 221229593 7324665 482283..483395 1 NC_011896.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 483395 guaB3 7324665 guaB3 Mycobacterium leprae Br4923 inosine 5-monophosphate dehydrogenase YP_002503009.1 482283 D 561304 CDS YP_002503010.1 221229594 7324666 483460..485169 1 NC_011896.1 cholesterol oxidase 485169 choD 7324666 choD Mycobacterium leprae Br4923 cholesterol oxidase YP_002503010.1 483460 D 561304 CDS YP_002503011.1 221229595 7326422 complement(486272..488650) 1 NC_011896.1 sugar phosphorylase 488650 7326422 MLBr_00392 Mycobacterium leprae Br4923 sugar phosphorylase YP_002503011.1 486272 R 561304 CDS YP_002503012.1 221229596 7326423 complement(488664..489449) 1 NC_011896.1 hydrolase 489449 7326423 MLBr_00393 Mycobacterium leprae Br4923 hydrolase YP_002503012.1 488664 R 561304 CDS YP_002503013.1 221229597 7326424 complement(489924..490436) 1 NC_011896.1 hypothetical protein 490436 7326424 MLBr_00394 Mycobacterium leprae Br4923 hypothetical protein YP_002503013.1 489924 R 561304 CDS YP_002503014.1 221229598 7326425 491052..492641 1 NC_011896.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 492641 guaA 7326425 guaA Mycobacterium leprae Br4923 GMP synthase YP_002503014.1 491052 D 561304 CDS YP_002503015.1 221229599 7324663 complement(492723..493832) 1 NC_011896.1 hypothetical protein 493832 7324663 MLBr_00396 Mycobacterium leprae Br4923 hypothetical protein YP_002503015.1 492723 R 561304 CDS YP_002503016.1 221229600 7326426 complement(493948..495756) 1 NC_011896.1 transporter protein 495756 7326426 MLBr_00397 Mycobacterium leprae Br4923 transporter protein YP_002503016.1 493948 R 561304 CDS YP_002503017.1 221229601 7326427 complement(496069..497106) 1 NC_011896.1 D-ribose-binding protein 497106 7326427 MLBr_00398 Mycobacterium leprae Br4923 D-ribose-binding protein YP_002503017.1 496069 R 561304 CDS YP_002503018.1 221229602 7326111 503226..504410 1 NC_011896.1 hypothetical protein 504410 7326111 MLBr_00405 Mycobacterium leprae Br4923 hypothetical protein YP_002503018.1 503226 D 561304 CDS YP_002503019.1 221229603 7326433 504468..504788 1 NC_011896.1 hypothetical protein 504788 7326433 MLBr_00406 Mycobacterium leprae Br4923 hypothetical protein YP_002503019.1 504468 D 561304 CDS YP_002503020.1 221229604 7326434 504802..505452 1 NC_011896.1 hypothetical protein 505452 7326434 MLBr_00407 Mycobacterium leprae Br4923 hypothetical protein YP_002503020.1 504802 D 561304 CDS YP_002503021.1 221229605 7326437 508336..508638 1 NC_011896.1 PE-family protein 508638 7326437 MLBr_00410 Mycobacterium leprae Br4923 PE-family protein YP_002503021.1 508336 D 561304 CDS YP_002503022.1 221229606 7325622 508764..509990 1 NC_011896.1 serine-rich protein 509990 7325622 MLBr_00411 Mycobacterium leprae Br4923 serine-rich protein YP_002503022.1 508764 D 561304 CDS YP_002503023.1 221229607 7325624 complement(511993..513282) 1 NC_011896.1 trehalose-6-phosphate phosphatase 513282 otsB2 7325624 otsB2 Mycobacterium leprae Br4923 trehalose-6-phosphate phosphatase YP_002503023.1 511993 R 561304 CDS YP_002503024.1 221229608 7325626 517653..518285 1 NC_011896.1 oxidoreductase 518285 7325626 MLBr_00418 Mycobacterium leprae Br4923 oxidoreductase YP_002503024.1 517653 D 561304 CDS YP_002503025.1 221229609 7325627 complement(518423..518899) 1 NC_011896.1 tRNA/rRNA methyltransferase 518899 7325627 MLBr_00419 Mycobacterium leprae Br4923 tRNA/rRNA methyltransferase YP_002503025.1 518423 R 561304 CDS YP_002503026.1 221229610 7325632 complement(523812..524297) 1 NC_011896.1 antioxidant protein 524297 bcp 7325632 bcp Mycobacterium leprae Br4923 antioxidant protein YP_002503026.1 523812 R 561304 CDS YP_002503027.1 221229611 7327257 524425..524652 1 NC_011896.1 hypothetical protein 524652 7327257 MLBr_00425 Mycobacterium leprae Br4923 hypothetical protein YP_002503027.1 524425 D 561304 CDS YP_002503028.1 221229612 7325432 524938..526152 1 NC_011896.1 hypothetical protein 526152 lppS 7325432 lppS Mycobacterium leprae Br4923 hypothetical protein YP_002503028.1 524938 D 561304 CDS YP_002503029.1 221229613 7324689 complement(526303..526950) 1 NC_011896.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 526950 7324689 MLBr_00427 Mycobacterium leprae Br4923 oligoribonuclease YP_002503029.1 526303 R 561304 CDS YP_002503030.1 221229614 7325635 complement(528630..529436) 1 NC_011896.1 oxidoreductase 529436 7325635 MLBr_00429 Mycobacterium leprae Br4923 oxidoreductase YP_002503030.1 528630 R 561304 CDS YP_002503031.1 221229615 7325636 529529..530893 1 NC_011896.1 hypothetical protein 530893 7325636 MLBr_00430 Mycobacterium leprae Br4923 hypothetical protein YP_002503031.1 529529 D 561304 CDS YP_002503032.1 221229616 7325637 complement(530925..531704) 1 NC_011896.1 hypothetical protein 531704 7325637 MLBr_00431 Mycobacterium leprae Br4923 hypothetical protein YP_002503032.1 530925 R 561304 CDS YP_002503033.1 221229617 7325643 547321..547797 1 NC_011896.1 hypothetical protein 547797 7325643 MLBr_00447 Mycobacterium leprae Br4923 hypothetical protein YP_002503033.1 547321 D 561304 CDS YP_002503034.1 221229618 7325644 548001..548273 1 NC_011896.1 hypothetical protein 548273 7325644 MLBr_00448 Mycobacterium leprae Br4923 hypothetical protein YP_002503034.1 548001 D 561304 CDS YP_002503035.1 221229619 7326012 complement(550202..551125) 1 NC_011896.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 551125 7326012 MLBr_00450 Mycobacterium leprae Br4923 pyridoxal biosynthesis lyase PdxS YP_002503035.1 550202 R 561304 CDS YP_002503036.1 221229620 7325646 complement(551200..552249) 1 NC_011896.1 hypothetical protein 552249 7325646 MLBr_00451 Mycobacterium leprae Br4923 hypothetical protein YP_002503036.1 551200 R 561304 CDS YP_002503037.1 221229621 7325647 complement(552249..553373) 1 NC_011896.1 glycosyltransferase 553373 7325647 MLBr_00452 Mycobacterium leprae Br4923 glycosyltransferase YP_002503037.1 552249 R 561304 CDS YP_002503038.1 221229622 7325648 complement(553383..554345) 1 NC_011896.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 554345 7325648 MLBr_00453 Mycobacterium leprae Br4923 lipid A biosynthesis lauroyl acyltransferase YP_002503038.1 553383 R 561304 CDS YP_002503039.1 221229623 7325649 complement(554342..555061) 1 NC_011896.1 phosphatidyltransferase 555061 pgsA 7325649 pgsA Mycobacterium leprae Br4923 phosphatidyltransferase YP_002503039.1 554342 R 561304 CDS YP_002503040.1 221229624 7327386 complement(555058..555678) 1 NC_011896.1 hypothetical protein 555678 7327386 MLBr_00455 Mycobacterium leprae Br4923 hypothetical protein YP_002503040.1 555058 R 561304 CDS YP_002503041.1 221229625 7325650 complement(555671..557779) 1 NC_011896.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 557779 thrS 7325650 thrS Mycobacterium leprae Br4923 threonyl-tRNA synthetase YP_002503041.1 555671 R 561304 CDS YP_002503042.1 221229626 7325651 complement(558372..559277) 1 NC_011896.1 oxidoreductase 559277 7325651 MLBr_00458 Mycobacterium leprae Br4923 oxidoreductase YP_002503042.1 558372 R 561304 CDS YP_002503043.1 221229627 7325657 561817..562104 1 NC_011896.1 hypothetical protein 562104 7325657 MLBr_00464 Mycobacterium leprae Br4923 hypothetical protein YP_002503043.1 561817 D 561304 CDS YP_002503044.1 221229628 7325659 563641..564546 1 NC_011896.1 hypothetical protein 564546 7325659 MLBr_00466 Mycobacterium leprae Br4923 hypothetical protein YP_002503044.1 563641 D 561304 CDS YP_002503045.1 221229629 7325660 564592..565236 1 NC_011896.1 hypothetical protein 565236 dedA 7325660 dedA Mycobacterium leprae Br4923 hypothetical protein YP_002503045.1 564592 D 561304 CDS YP_002503046.1 221229630 7326163 complement(566066..566848) 1 NC_011896.1 hypothetical protein 566848 7326163 MLBr_00468 Mycobacterium leprae Br4923 hypothetical protein YP_002503046.1 566066 R 561304 CDS YP_002503047.1 221229631 7325662 complement(571612..571902) 1 NC_011896.1 hypothetical protein 571902 7325662 MLBr_00470 Mycobacterium leprae Br4923 hypothetical protein YP_002503047.1 571612 R 561304 CDS YP_002503048.1 221229632 7325664 574041..574283 1 NC_011896.1 hypothetical protein 574283 7325664 MLBr_00472 Mycobacterium leprae Br4923 hypothetical protein YP_002503048.1 574041 D 561304 CDS YP_002503049.1 221229633 7325665 574547..574819 1 NC_011896.1 hypothetical protein 574819 7325665 MLBr_00473 Mycobacterium leprae Br4923 hypothetical protein YP_002503049.1 574547 D 561304 CDS YP_002503050.1 221229634 7325666 575478..576149 1 NC_011896.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 576149 7325666 MLBr_00474 Mycobacterium leprae Br4923 glutamine amidotransferase subunit PdxT YP_002503050.1 575478 D 561304 CDS YP_002503051.1 221229635 7325667 576370..577125 1 NC_011896.1 hypothetical protein 577125 7325667 MLBr_00475 Mycobacterium leprae Br4923 hypothetical protein YP_002503051.1 576370 D 561304 CDS YP_002503052.1 221229636 7325672 581233..581799 1 NC_011896.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 581799 ruvC 7325672 ruvC Mycobacterium leprae Br4923 Holliday junction resolvase YP_002503052.1 581233 D 561304 CDS YP_002503053.1 221229637 7325964 581796..582407 1 NC_011896.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 582407 ruvA 7325964 ruvA Mycobacterium leprae Br4923 Holliday junction DNA helicase RuvA YP_002503053.1 581796 D 561304 CDS YP_002503054.1 221229638 7325962 582404..583453 1 NC_011896.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 583453 ruvB 7325962 ruvB Mycobacterium leprae Br4923 Holliday junction DNA helicase RuvB YP_002503054.1 582404 D 561304 CDS YP_002503055.1 221229639 7325963 complement(584390..587956) 1 NC_011896.1 acyl-CoA synthetase 587956 fadD9 7325963 fadD9 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002503055.1 584390 R 561304 CDS YP_002503056.1 221229640 7325262 complement(588052..589392) 1 NC_011896.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 589392 gabT 7325262 gabT Mycobacterium leprae Br4923 4-aminobutyrate aminotransferase YP_002503056.1 588052 R 561304 CDS YP_002503057.1 221229641 7325326 589661..590005 1 NC_011896.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 590005 yajC 7325326 yajC Mycobacterium leprae Br4923 preprotein translocase subunit YajC YP_002503057.1 589661 D 561304 CDS YP_002503058.1 221229642 7325673 590045..591838 1 NC_011896.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 591838 secD 7325673 secD Mycobacterium leprae Br4923 preprotein translocase subunit SecD YP_002503058.1 590045 D 561304 CDS YP_002503059.1 221229643 7325975 591843..593258 1 NC_011896.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 593258 secF 7325975 secF Mycobacterium leprae Br4923 preprotein translocase subunit SecF YP_002503059.1 591843 D 561304 CDS YP_002503060.1 221229644 7325977 593303..594970 1 NC_011896.1 lipoprotein 594970 7325977 MLBr_00489 Mycobacterium leprae Br4923 lipoprotein YP_002503060.1 593303 D 561304 CDS YP_002503061.1 221229645 7327215 595616..597979 1 NC_011896.1 GTP pyrophosphokinase 597979 relA 7327215 relA Mycobacterium leprae Br4923 GTP pyrophosphokinase YP_002503061.1 595616 D 561304 CDS YP_002503062.1 221229646 7326615 complement(598038..598925) 1 NC_011896.1 peptidyl-prolyl cis-trans isomerase 598925 ppiB 7326615 ppiB Mycobacterium leprae Br4923 peptidyl-prolyl cis-trans isomerase YP_002503062.1 598038 R 561304 CDS YP_002503063.1 221229647 7325001 599089..599745 1 NC_011896.1 hydrolase 599745 7325001 MLBr_00493 Mycobacterium leprae Br4923 hydrolase YP_002503063.1 599089 D 561304 CDS YP_002503064.1 221229648 7325675 599749..601032 1 NC_011896.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 601032 hisS 7325675 hisS Mycobacterium leprae Br4923 histidyl-tRNA synthetase YP_002503064.1 599749 D 561304 CDS YP_002503065.1 221229649 7325680 606848..608617 1 NC_011896.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 608617 aspS 7325680 aspS Mycobacterium leprae Br4923 aspartyl-tRNA synthetase YP_002503065.1 606848 D 561304 CDS YP_002503066.1 221229650 7325685 617510..618451 1 NC_011896.1 hypothetical protein 618451 7325685 MLBr_00508 Mycobacterium leprae Br4923 hypothetical protein YP_002503066.1 617510 D 561304 CDS YP_002503067.1 221229651 7325687 619675..621096 1 NC_011896.1 recombination factor protein RarA 621096 7325687 MLBr_00510 Mycobacterium leprae Br4923 recombination factor protein RarA YP_002503067.1 619675 D 561304 CDS YP_002503068.1 221229652 7325689 622168..624894 1 NC_011896.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 624894 alaS 7325689 alaS Mycobacterium leprae Br4923 alanyl-tRNA synthetase YP_002503068.1 622168 D 561304 CDS YP_002503069.1 221229653 7327198 624895..625449 1 NC_011896.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 625449 7327198 MLBr_00513 Mycobacterium leprae Br4923 Holliday junction resolvase-like protein YP_002503069.1 624895 D 561304 CDS YP_002503070.1 221229654 7325690 625442..626707 1 NC_011896.1 hypothetical protein 626707 7325690 MLBr_00514 Mycobacterium leprae Br4923 hypothetical protein YP_002503070.1 625442 D 561304 CDS YP_002503071.1 221229655 7325691 626685..627521 1 NC_011896.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 627521 aroE 7325691 aroE Mycobacterium leprae Br4923 shikimate 5-dehydrogenase YP_002503071.1 626685 D 561304 CDS YP_002503072.1 221229656 7327233 627750..628973 1 NC_011896.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 628973 aroF 7327233 aroF Mycobacterium leprae Br4923 chorismate synthase YP_002503072.1 627750 D 561304 CDS YP_002503073.1 221229657 7327234 628981..629580 1 NC_011896.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 629580 aroK 7327234 aroK Mycobacterium leprae Br4923 shikimate kinase YP_002503073.1 628981 D 561304 CDS YP_002503074.1 221229658 7327236 629577..630662 1 NC_011896.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 630662 aroB 7327236 aroB Mycobacterium leprae Br4923 3-dehydroquinate synthase YP_002503074.1 629577 D 561304 CDS YP_002503075.1 221229659 7327231 630662..631099 1 NC_011896.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 631099 aroD 7327231 aroD Mycobacterium leprae Br4923 3-dehydroquinate dehydratase YP_002503075.1 630662 D 561304 CDS YP_002503076.1 221229660 7327232 complement(631188..631796) 1 NC_011896.1 hypothetical protein 631796 7327232 MLBr_00520 Mycobacterium leprae Br4923 hypothetical protein YP_002503076.1 631188 R 561304 CDS YP_002503077.1 221229661 7325692 631830..632960 1 NC_011896.1 peptidase 632960 pepQ 7325692 pepQ Mycobacterium leprae Br4923 peptidase YP_002503077.1 631830 D 561304 CDS YP_002503078.1 221229662 7327375 632976..633539 1 NC_011896.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 633539 efp 7327375 efp Mycobacterium leprae Br4923 elongation factor P YP_002503078.1 632976 D 561304 CDS YP_002503079.1 221229663 7325221 633542..634114 1 NC_011896.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 634114 nusB 7325221 nusB Mycobacterium leprae Br4923 transcription antitermination protein NusB YP_002503079.1 633542 D 561304 CDS YP_002503080.1 221229664 7327335 634652..637504 1 NC_011896.1 amino acid decarboxylase 637504 adi 7327335 adi Mycobacterium leprae Br4923 amino acid decarboxylase YP_002503080.1 634652 D 561304 CDS YP_002503081.1 221229665 7327191 637501..637677 1 NC_011896.1 hypothetical protein 637677 7327191 MLBr_00525 Mycobacterium leprae Br4923 hypothetical protein YP_002503081.1 637501 D 561304 CDS YP_002503082.1 221229666 7325694 complement(639687..639941) 1 NC_011896.1 hypothetical protein 639941 7325694 MLBr_00527 Mycobacterium leprae Br4923 hypothetical protein YP_002503082.1 639687 R 561304 CDS YP_002503083.1 221229667 7326274 645590..646555 1 NC_011896.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 646555 pyrB 7326274 pyrB Mycobacterium leprae Br4923 aspartate carbamoyltransferase YP_002503083.1 645590 D 561304 CDS YP_002503084.1 221229668 7325045 646552..647844 1 NC_011896.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 647844 pyrC 7325045 pyrC Mycobacterium leprae Br4923 dihydroorotase YP_002503084.1 646552 D 561304 CDS YP_002503085.1 221229669 7325699 648431..649558 1 NC_011896.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 649558 carA 7325699 carA Mycobacterium leprae Br4923 carbamoyl phosphate synthase small subunit YP_002503085.1 648431 D 561304 CDS YP_002503086.1 221229670 7327266 649617..653006 1 NC_011896.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 653006 carB 7327266 carB Mycobacterium leprae Br4923 carbamoyl phosphate synthase large subunit YP_002503086.1 649617 D 561304 CDS YP_002503087.1 221229671 7327267 653003..653851 1 NC_011896.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 653851 pyrF 7327267 pyrF Mycobacterium leprae Br4923 orotidine 5'-phosphate decarboxylase YP_002503087.1 653003 D 561304 CDS YP_002503088.1 221229672 7325048 654138..654446 1 NC_011896.1 PE-family protein 654446 PE 7325048 PE Mycobacterium leprae Br4923 PE-family protein YP_002503088.1 654138 D 561304 CDS YP_002503089.1 221229673 7327366 654443..656059 1 NC_011896.1 PPE family protein 656059 PPE 7327366 PPE Mycobacterium leprae Br4923 PPE family protein YP_002503089.1 654443 D 561304 CDS YP_002503090.1 221229674 7324989 656904..657221 1 NC_011896.1 integration host factor 657221 mihF 7324989 mihF Mycobacterium leprae Br4923 integration host factor YP_002503090.1 656904 D 561304 CDS YP_002503091.1 221229675 7324902 657275..657907 1 NC_011896.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 657907 gmk 7324902 gmk Mycobacterium leprae Br4923 guanylate kinase YP_002503091.1 657275 D 561304 CDS YP_002503092.1 221229676 7326602 657989..658321 1 NC_011896.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 658321 7326602 MLBr_00542 Mycobacterium leprae Br4923 DNA-directed RNA polymerase subunit omega YP_002503092.1 657989 D 561304 CDS YP_002503093.1 221229677 7325700 658342..659601 1 NC_011896.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 659601 dfp 7325700 dfp Mycobacterium leprae Br4923 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002503093.1 658342 D 561304 CDS YP_002503094.1 221229678 7326170 659730..660941 1 NC_011896.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 660941 metK 7326170 metK Mycobacterium leprae Br4923 S-adenosylmethionine synthetase YP_002503094.1 659730 D 561304 CDS YP_002503095.1 221229679 7325701 664269..666224 1 NC_011896.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 666224 priA 7325701 priA Mycobacterium leprae Br4923 primosome assembly protein PriA YP_002503095.1 664269 D 561304 CDS YP_002503096.1 221229680 7325702 667340..667825 1 NC_011896.1 marR-family transcriptional regulator 667825 7325702 MLBr_00550 Mycobacterium leprae Br4923 marR-family transcriptional regulator YP_002503096.1 667340 D 561304 CDS YP_002503097.1 221229681 7326438 complement(668007..668831) 1 NC_011896.1 methyltransferase 668831 7326438 MLBr_00551 Mycobacterium leprae Br4923 methyltransferase YP_002503097.1 668007 R 561304 CDS YP_002503098.1 221229682 7326928 669012..669968 1 NC_011896.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 669968 fmt 7326928 fmt Mycobacterium leprae Br4923 methionyl-tRNA formyltransferase YP_002503098.1 669012 D 561304 CDS YP_002503099.1 221229683 7325299 671425..672099 1 NC_011896.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 672099 rpe 7325299 rpe Mycobacterium leprae Br4923 ribulose-phosphate 3-epimerase YP_002503099.1 671425 D 561304 CDS YP_002503100.1 221229684 7326639 672096..673115 1 NC_011896.1 bifunctional riboflavin-specific deaminase/reductase 673115 ribG 7326639 ribG Mycobacterium leprae Br4923 bifunctional riboflavin-specific deaminase/reductase YP_002503100.1 672096 D 561304 CDS YP_002503101.1 221229685 7326623 complement(673159..674688) 1 NC_011896.1 integral membrane drug transport protein 674688 7326623 MLBr_00556 Mycobacterium leprae Br4923 integral membrane drug transport protein YP_002503101.1 673159 R 561304 CDS YP_002503102.1 221229686 7326929 complement(674688..675404) 1 NC_011896.1 lipoprotein 675404 lprG 7326929 lprG Mycobacterium leprae Br4923 lipoprotein YP_002503102.1 674688 R 561304 CDS YP_002503103.1 221229687 7325423 675561..676184 1 NC_011896.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 676184 ribC 7325423 ribC Mycobacterium leprae Br4923 riboflavin synthase subunit alpha YP_002503103.1 675561 D 561304 CDS YP_002503104.1 221229688 7326621 676311..677618 1 NC_011896.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 677618 ribA 7326621 ribA Mycobacterium leprae Br4923 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_002503104.1 676311 D 561304 CDS YP_002503105.1 221229689 7326620 677615..678097 1 NC_011896.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 678097 ribH 7326620 ribH Mycobacterium leprae Br4923 6,7-dimethyl-8-ribityllumazine synthase YP_002503105.1 677615 D 561304 CDS YP_002503106.1 221229690 7326624 678094..678564 1 NC_011896.1 hypothetical protein 678564 7326624 MLBr_00561 Mycobacterium leprae Br4923 hypothetical protein YP_002503106.1 678094 D 561304 CDS YP_002503107.1 221229691 7326930 678879..680822 1 NC_011896.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 680822 uvrC 7326930 uvrC Mycobacterium leprae Br4923 excinuclease ABC subunit C YP_002503107.1 678879 D 561304 CDS YP_002503108.1 221229692 7327307 680819..681715 1 NC_011896.1 hypothetical protein 681715 7327307 MLBr_00563 Mycobacterium leprae Br4923 hypothetical protein YP_002503108.1 680819 D 561304 CDS YP_002503109.1 221229693 7326931 681712..682791 1 NC_011896.1 hypothetical protein 682791 7326931 MLBr_00564 Mycobacterium leprae Br4923 hypothetical protein YP_002503109.1 681712 D 561304 CDS YP_002503110.1 221229694 7326932 682788..683765 1 NC_011896.1 transcriptional regulator 683765 7326932 MLBr_00565 Mycobacterium leprae Br4923 transcriptional regulator YP_002503110.1 682788 D 561304 CDS YP_002503111.1 221229695 7326935 686822..687415 1 NC_011896.1 hypothetical protein 687415 7326935 MLBr_00568 Mycobacterium leprae Br4923 hypothetical protein YP_002503111.1 686822 D 561304 CDS YP_002503112.1 221229696 7326936 complement(693620..694435) 1 NC_011896.1 hypothetical protein 694435 7326936 MLBr_00569 Mycobacterium leprae Br4923 hypothetical protein YP_002503112.1 693620 R 561304 CDS YP_002503113.1 221229697 7326937 694898..695917 1 NC_011896.1 glyceraldehyde 3-phosphate dehydrogenase 695917 gap 7326937 gap Mycobacterium leprae Br4923 glyceraldehyde 3-phosphate dehydrogenase YP_002503113.1 694898 D 561304 CDS YP_002503114.1 221229698 7325330 695920..697170 1 NC_011896.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 697170 pgk 7325330 pgk Mycobacterium leprae Br4923 phosphoglycerate kinase YP_002503114.1 695920 D 561304 CDS YP_002503115.1 221229699 7327383 697167..697952 1 NC_011896.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 697952 tpiA 7327383 tpiA Mycobacterium leprae Br4923 triosephosphate isomerase YP_002503115.1 697167 D 561304 CDS YP_002503116.1 221229700 7327278 697936..698211 1 NC_011896.1 hypothetical protein 698211 7327278 MLBr_00573 Mycobacterium leprae Br4923 hypothetical protein YP_002503116.1 697936 D 561304 CDS YP_002503117.1 221229701 7326938 698208..698525 1 NC_011896.1 hypothetical protein 698525 7326938 MLBr_00574 Mycobacterium leprae Br4923 hypothetical protein YP_002503117.1 698208 D 561304 CDS YP_002503118.1 221229702 7326939 698683..698901 1 NC_011896.1 hypothetical protein 698901 7326939 MLBr_00575 Mycobacterium leprae Br4923 hypothetical protein YP_002503118.1 698683 D 561304 CDS YP_002503119.1 221229703 7326940 699717..699947 1 NC_011896.1 hypothetical protein 699947 7326940 MLBr_00576 Mycobacterium leprae Br4923 hypothetical protein YP_002503119.1 699717 D 561304 CDS YP_002503120.1 221229704 7326941 699959..700192 1 NC_011896.1 preprotein translocase subunit SecG 700192 secG 7326941 secG Mycobacterium leprae Br4923 preprotein translocase subunit SecG YP_002503120.1 699959 D 561304 CDS YP_002503121.1 221229705 7326942 700223..703027 1 NC_011896.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 703027 ppc 7326942 ppc Mycobacterium leprae Br4923 phosphoenolpyruvate carboxylase YP_002503121.1 700223 D 561304 CDS YP_002503122.1 221229706 7324984 complement(703251..703994) 1 NC_011896.1 6-phosphogluconolactonase 703994 pgl 7324984 pgl Mycobacterium leprae Br4923 6-phosphogluconolactonase YP_002503122.1 703251 R 561304 CDS YP_002503123.1 221229707 7327384 complement(704010..704807) 1 NC_011896.1 hypothetical protein 704807 7327384 MLBr_00580 Mycobacterium leprae Br4923 hypothetical protein YP_002503123.1 704010 R 561304 CDS YP_002503124.1 221229708 7327329 complement(706470..707597) 1 NC_011896.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 707597 tal 7327329 tal Mycobacterium leprae Br4923 transaldolase YP_002503124.1 706470 R 561304 CDS YP_002503125.1 221229709 7326010 complement(707614..709713) 1 NC_011896.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 709713 tkt 7326010 tkt Mycobacterium leprae Br4923 transketolase YP_002503125.1 707614 R 561304 CDS YP_002503126.1 221229710 7326026 709913..710878 1 NC_011896.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 710878 ctaB 7326026 ctaB Mycobacterium leprae Br4923 protoheme IX farnesyltransferase YP_002503126.1 709913 D 561304 CDS YP_002503127.1 221229711 7326944 complement(712677..713612) 1 NC_011896.1 hypothetical protein 713612 7326944 MLBr_00587 Mycobacterium leprae Br4923 hypothetical protein YP_002503127.1 712677 R 561304 CDS YP_002503128.1 221229712 7326945 713867..714109 1 NC_011896.1 hypothetical protein 714109 7326945 MLBr_00588 Mycobacterium leprae Br4923 hypothetical protein YP_002503128.1 713867 D 561304 CDS YP_002503129.1 221229713 7326946 complement(714243..715040) 1 NC_011896.1 hypothetical protein 715040 7326946 MLBr_00589 Mycobacterium leprae Br4923 hypothetical protein YP_002503129.1 714243 R 561304 CDS YP_002503130.1 221229714 7326947 complement(715040..715987) 1 NC_011896.1 ABC transporter ATP-binding protein 715987 7326947 MLBr_00590 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503130.1 715040 R 561304 CDS YP_002503131.1 221229715 7326948 complement(715984..717765) 1 NC_011896.1 hypothetical protein 717765 7326948 MLBr_00591 Mycobacterium leprae Br4923 hypothetical protein YP_002503131.1 715984 R 561304 CDS YP_002503132.1 221229716 7326949 717881..718645 1 NC_011896.1 DNA-binding protein 718645 7326949 MLBr_00592 Mycobacterium leprae Br4923 DNA-binding protein YP_002503132.1 717881 D 561304 CDS YP_002503133.1 221229717 7326950 718697..721306 1 NC_011896.1 hypothetical protein 721306 7326950 MLBr_00593 Mycobacterium leprae Br4923 hypothetical protein YP_002503133.1 718697 D 561304 CDS YP_002503134.1 221229718 7326951 721303..722481 1 NC_011896.1 hypothetical protein 722481 7326951 MLBr_00594 Mycobacterium leprae Br4923 hypothetical protein YP_002503134.1 721303 D 561304 CDS YP_002503135.1 221229719 7326952 722478..723260 1 NC_011896.1 ABC transporter ATP-binding protein 723260 7326952 MLBr_00595 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503135.1 722478 D 561304 CDS YP_002503136.1 221229720 7326953 723263..724519 1 NC_011896.1 aminotransferase 724519 7326953 MLBr_00596 Mycobacterium leprae Br4923 aminotransferase YP_002503136.1 723263 D 561304 CDS YP_002503137.1 221229721 7326954 724516..725013 1 NC_011896.1 hypothetical protein 725013 7326954 MLBr_00597 Mycobacterium leprae Br4923 hypothetical protein YP_002503137.1 724516 D 561304 CDS YP_002503138.1 221229722 7326955 724988..725335 1 NC_011896.1 hypothetical protein 725335 7326955 MLBr_00598 Mycobacterium leprae Br4923 hypothetical protein YP_002503138.1 724988 D 561304 CDS YP_002503139.1 221229723 7326959 735012..736127 1 NC_011896.1 hypothetical protein 736127 7326959 MLBr_00603 Mycobacterium leprae Br4923 hypothetical protein YP_002503139.1 735012 D 561304 CDS YP_002503140.1 221229724 7326960 complement(736164..736424) 1 NC_011896.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 736424 rpsT 7326960 rpsT Mycobacterium leprae Br4923 30S ribosomal protein S20 YP_002503140.1 736164 R 561304 CDS YP_002503141.1 221229725 7325960 736559..738244 1 NC_011896.1 hypothetical protein 738244 7325960 MLBr_00605 Mycobacterium leprae Br4923 hypothetical protein YP_002503141.1 736559 D 561304 CDS YP_002503142.1 221229726 7326961 738244..739221 1 NC_011896.1 hypothetical protein 739221 7326961 MLBr_00606 Mycobacterium leprae Br4923 hypothetical protein YP_002503142.1 738244 D 561304 CDS YP_002503143.1 221229727 7326962 739221..740060 1 NC_011896.1 hypothetical protein 740060 7326962 MLBr_00607 Mycobacterium leprae Br4923 hypothetical protein YP_002503143.1 739221 D 561304 CDS YP_002503144.1 221229728 7326966 742725..744665 1 NC_011896.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 744665 lepA 7326966 lepA Mycobacterium leprae Br4923 GTP-binding protein LepA YP_002503144.1 742725 D 561304 CDS YP_002503145.1 221229729 7326968 747786..748073 1 NC_011896.1 hypothetical protein 748073 7326968 MLBr_00614 Mycobacterium leprae Br4923 hypothetical protein YP_002503145.1 747786 D 561304 CDS YP_002503146.1 221229730 7326969 748391..749437 1 NC_011896.1 sulfate-binding protein 749437 subI 7326969 subI Mycobacterium leprae Br4923 sulfate-binding protein YP_002503146.1 748391 D 561304 CDS YP_002503147.1 221229731 7326970 753541..754044 1 NC_011896.1 hypothetical protein 754044 mtb12 7326970 mtb12 Mycobacterium leprae Br4923 hypothetical protein YP_002503147.1 753541 D 561304 CDS YP_002503148.1 221229732 7326973 756779..757810 1 NC_011896.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 757810 hrcA 7326973 hrcA Mycobacterium leprae Br4923 heat-inducible transcription repressor YP_002503148.1 756779 D 561304 CDS YP_002503149.1 221229733 7324694 757882..759018 1 NC_011896.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 759018 dnaJ2 7324694 dnaJ2 Mycobacterium leprae Br4923 molecular chaperone DnaJ YP_002503149.1 757882 D 561304 CDS YP_002503150.1 221229734 7326180 759050..759823 1 NC_011896.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 759823 7326180 MLBr_00626 Mycobacterium leprae Br4923 16S ribosomal RNA methyltransferase RsmE YP_002503150.1 759050 D 561304 CDS YP_002503151.1 221229735 7326974 760123..761172 1 NC_011896.1 phoH-family protein 761172 phoH 7326974 phoH Mycobacterium leprae Br4923 phoH-family protein YP_002503151.1 760123 D 561304 CDS YP_002503152.1 221229736 7327392 761203..761739 1 NC_011896.1 metalloprotease 761739 7327392 MLBr_00628 Mycobacterium leprae Br4923 metalloprotease YP_002503152.1 761203 D 561304 CDS YP_002503153.1 221229737 7326976 763041..763367 1 NC_011896.1 hypothetical protein 763367 7326976 MLBr_00630 Mycobacterium leprae Br4923 hypothetical protein YP_002503153.1 763041 D 561304 CDS YP_002503154.1 221229738 7326977 763485..764393 1 NC_011896.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 764393 era 7326977 era Mycobacterium leprae Br4923 GTP-binding protein Era YP_002503154.1 763485 D 561304 CDS YP_002503155.1 221229739 7327207 765920..766726 1 NC_011896.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 766726 recO 7327207 recO Mycobacterium leprae Br4923 DNA repair protein RecO YP_002503155.1 765920 D 561304 CDS YP_002503156.1 221229740 7326978 766719..767609 1 NC_011896.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 767609 7326978 MLBr_00634 Mycobacterium leprae Br4923 UDP pyrophosphate synthase YP_002503156.1 766719 D 561304 CDS YP_002503157.1 221229741 7326982 769127..771280 1 NC_011896.1 ATP-dependent DNA helicase 771280 uvrD2 7326982 uvrD2 Mycobacterium leprae Br4923 ATP-dependent DNA helicase YP_002503157.1 769127 D 561304 CDS YP_002503158.1 221229742 7327309 771435..771737 1 NC_011896.1 hypothetical protein 771737 7327309 MLBr_00638 Mycobacterium leprae Br4923 hypothetical protein YP_002503158.1 771435 D 561304 CDS YP_002503159.1 221229743 7326983 771731..772000 1 NC_011896.1 transcriptional regulator 772000 whiB7 7326983 whiB7 Mycobacterium leprae Br4923 transcriptional regulator YP_002503159.1 771731 D 561304 CDS YP_002503160.1 221229744 7327318 complement(772077..773498) 1 NC_011896.1 hypothetical protein 773498 7327318 MLBr_00640 Mycobacterium leprae Br4923 hypothetical protein YP_002503160.1 772077 R 561304 CDS YP_002503161.1 221229745 7326985 complement(774515..775954) 1 NC_011896.1 hypothetical protein 775954 7326985 MLBr_00642 Mycobacterium leprae Br4923 hypothetical protein YP_002503161.1 774515 R 561304 CDS YP_002503162.1 221229746 7326986 776017..777039 1 NC_011896.1 hypothetical protein 777039 7326986 MLBr_00643 Mycobacterium leprae Br4923 hypothetical protein YP_002503162.1 776017 D 561304 CDS YP_002503163.1 221229747 7326987 777185..780136 1 NC_011896.1 hypothetical protein 780136 7326987 MLBr_00644 Mycobacterium leprae Br4923 hypothetical protein YP_002503163.1 777185 D 561304 CDS YP_002503164.1 221229748 7326997 complement(793601..793882) 1 NC_011896.1 hypothetical protein 793882 7326997 MLBr_00656 Mycobacterium leprae Br4923 hypothetical protein YP_002503164.1 793601 R 561304 CDS YP_002503165.1 221229749 7325242 complement(795546..795872) 1 NC_011896.1 hypothetical protein 795872 7325242 MLBr_00659 Mycobacterium leprae Br4923 hypothetical protein YP_002503165.1 795546 R 561304 CDS YP_002503166.1 221229750 7326999 complement(796056..797258) 1 NC_011896.1 acyl-CoA dehydrogenase 797258 fadE23 7326999 fadE23 Mycobacterium leprae Br4923 acyl-CoA dehydrogenase YP_002503166.1 796056 R 561304 CDS YP_002503167.1 221229751 7325270 complement(797301..798698) 1 NC_011896.1 acyl-CoA dehydrogenase 798698 fadE24 7325270 fadE24 Mycobacterium leprae Br4923 acyl-CoA dehydrogenase YP_002503167.1 797301 R 561304 CDS YP_002503168.1 221229752 7325271 complement(798775..799542) 1 NC_011896.1 monophosphatase 799542 7325271 MLBr_00662 Mycobacterium leprae Br4923 monophosphatase YP_002503168.1 798775 R 561304 CDS YP_002503169.1 221229753 7327000 799670..799984 1 NC_011896.1 hypothetical protein 799984 7327000 MLBr_00663 Mycobacterium leprae Br4923 hypothetical protein YP_002503169.1 799670 D 561304 CDS YP_002503170.1 221229754 7327001 800125..800388 1 NC_011896.1 hypothetical protein 800388 7327001 MLBr_00664 Mycobacterium leprae Br4923 hypothetical protein YP_002503170.1 800125 D 561304 CDS YP_002503171.1 221229755 7327003 complement(801985..803355) 1 NC_011896.1 NADPH-ferredoxin reductase 803355 fprA 7327003 fprA Mycobacterium leprae Br4923 NADPH-ferredoxin reductase YP_002503171.1 801985 R 561304 CDS YP_002503172.1 221229756 7325309 803535..804659 1 NC_011896.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 804659 prfB 7325309 prfB Mycobacterium leprae Br4923 peptide chain release factor 2 YP_002503172.1 803535 D 561304 CDS YP_002503173.1 221229757 7327004 805929..806618 1 NC_011896.1 cell division ATP-binding protein 806618 ftsE 7327004 ftsE Mycobacterium leprae Br4923 cell division ATP-binding protein YP_002503173.1 805929 D 561304 CDS YP_002503174.1 221229758 7325312 806619..807512 1 NC_011896.1 hypothetical protein 807512 ftsX 7325312 ftsX Mycobacterium leprae Br4923 hypothetical protein YP_002503174.1 806619 D 561304 CDS YP_002503175.1 221229759 7325316 807515..807997 1 NC_011896.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 807997 smpB 7325316 smpB Mycobacterium leprae Br4923 SsrA-binding protein YP_002503175.1 807515 D 561304 CDS YP_002503176.1 221229760 7327006 810701..811549 1 NC_011896.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 811549 folD 7327006 folD Mycobacterium leprae Br4923 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002503176.1 810701 D 561304 CDS YP_002503177.1 221229761 7325303 811552..811827 1 NC_011896.1 hypothetical protein 811827 7325303 MLBr_00675 Mycobacterium leprae Br4923 hypothetical protein YP_002503177.1 811552 D 561304 CDS YP_002503178.1 221229762 7327007 complement(811824..812300) 1 NC_011896.1 hypothetical protein 812300 7327007 MLBr_00676 Mycobacterium leprae Br4923 hypothetical protein YP_002503178.1 811824 R 561304 CDS YP_002503179.1 221229763 7326192 complement(813441..813968) 1 NC_011896.1 hypothetical protein 813968 7326192 MLBr_00678 Mycobacterium leprae Br4923 hypothetical protein YP_002503179.1 813441 R 561304 CDS YP_002503180.1 221229764 7326193 814154..814381 1 NC_011896.1 hypothetical protein 814381 7326193 MLBr_00679 Mycobacterium leprae Br4923 hypothetical protein YP_002503180.1 814154 D 561304 CDS YP_002503181.1 221229765 7326196 complement(817118..818266) 1 NC_011896.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 818266 metX 7326196 metX Mycobacterium leprae Br4923 homoserine O-acetyltransferase YP_002503181.1 817118 R 561304 CDS YP_002503182.1 221229766 7324702 complement(821188..822099) 1 NC_011896.1 hydrolase 822099 7324702 MLBr_00685 Mycobacterium leprae Br4923 hydrolase YP_002503182.1 821188 R 561304 CDS YP_002503183.1 221229767 7326197 822135..823166 1 NC_011896.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 823166 trpS 7326197 trpS Mycobacterium leprae Br4923 tryptophanyl-tRNA synthetase YP_002503183.1 822135 D 561304 CDS YP_002503184.1 221229768 7327285 823178..824119 1 NC_011896.1 hypothetical protein 824119 7327285 MLBr_00687 Mycobacterium leprae Br4923 hypothetical protein YP_002503184.1 823178 D 561304 CDS YP_002503185.1 221229769 7326007 complement(827886..829121) 1 NC_011896.1 D-alanyl-D-alanine carboxypeptidase 829121 7326007 MLBr_00691 Mycobacterium leprae Br4923 D-alanyl-D-alanine carboxypeptidase YP_002503185.1 827886 R 561304 CDS YP_002503186.1 221229770 7326203 complement(833881..834675) 1 NC_011896.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 834675 sdhB 7326203 sdhB Mycobacterium leprae Br4923 succinate dehydrogenase iron-sulfur subunit YP_002503186.1 833881 R 561304 CDS YP_002503187.1 221229771 7325970 complement(834675..836429) 1 NC_011896.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 836429 sdhA 7325970 sdhA Mycobacterium leprae Br4923 succinate dehydrogenase flavoprotein subunit YP_002503187.1 834675 R 561304 CDS YP_002503188.1 221229772 7325969 complement(836450..836941) 1 NC_011896.1 succinate dehydrogenase hydrophobic membrane anchor protei 836941 sdhD 7325969 sdhD Mycobacterium leprae Br4923 succinate dehydrogenase hydrophobic membrane anchor protei YP_002503188.1 836450 R 561304 CDS YP_002503189.1 221229773 7325972 complement(836938..837399) 1 NC_011896.1 succinate dehydrogenase cytochrome B-556 subunit 837399 sdhC 7325972 sdhC Mycobacterium leprae Br4923 succinate dehydrogenase cytochrome B-556 subunit YP_002503189.1 836938 R 561304 CDS YP_002503190.1 221229774 7325971 837688..838776 1 NC_011896.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 838776 add 7325971 add Mycobacterium leprae Br4923 adenosine deaminase YP_002503190.1 837688 D 561304 CDS YP_002503191.1 221229775 7326205 complement(840891..842162) 1 NC_011896.1 hypothetical protein 842162 7326205 MLBr_00703 Mycobacterium leprae Br4923 hypothetical protein YP_002503191.1 840891 R 561304 CDS YP_002503192.1 221229776 7327301 complement(843856..845472) 1 NC_011896.1 phospho-sugar mutase 845472 pmmB 7327301 pmmB Mycobacterium leprae Br4923 phospho-sugar mutase YP_002503192.1 843856 R 561304 CDS YP_002503193.1 221229777 7324974 complement(845469..846275) 1 NC_011896.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 846275 deoD 7324974 deoD Mycobacterium leprae Br4923 purine nucleoside phosphorylase YP_002503193.1 845469 R 561304 CDS YP_002503194.1 221229778 7326208 complement(849837..850316) 1 NC_011896.1 hypothetical protein 850316 7326208 MLBr_00711 Mycobacterium leprae Br4923 hypothetical protein YP_002503194.1 849837 R 561304 CDS YP_002503195.1 221229779 7325405 851957..853714 1 NC_011896.1 glycerol-3-phosphate dehydrogenase 853714 glpD 7325405 glpD Mycobacterium leprae Br4923 glycerol-3-phosphate dehydrogenase YP_002503195.1 851957 D 561304 CDS YP_002503196.1 221229780 7326210 854785..855699 1 NC_011896.1 hydrolase 855699 lpqC 7326210 lpqC Mycobacterium leprae Br4923 hydrolase YP_002503196.1 854785 D 561304 CDS YP_002503197.1 221229781 7325384 complement(859926..860597) 1 NC_011896.1 TetR family transcriptional regulator 860597 7325384 MLBr_00717 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002503197.1 859926 R 561304 CDS YP_002503198.1 221229782 7325988 complement(867705..869501) 1 NC_011896.1 acetyl/propionyl CoA carboxylase subunit alpha 869501 bccA 7325988 bccA Mycobacterium leprae Br4923 acetyl/propionyl CoA carboxylase subunit alpha YP_002503198.1 867705 R 561304 CDS YP_002503199.1 221229783 7326216 complement(870037..870927) 1 NC_011896.1 thiosulfate sulfurtransferase 870927 sseA 7326216 sseA Mycobacterium leprae Br4923 thiosulfate sulfurtransferase YP_002503199.1 870037 R 561304 CDS YP_002503200.1 221229784 7326002 complement(871128..871769) 1 NC_011896.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 871769 7326002 MLBr_00729 Mycobacterium leprae Br4923 Maf-like protein YP_002503200.1 871128 R 561304 CDS YP_002503201.1 221229785 7326217 complement(871766..872020) 1 NC_011896.1 hypothetical protein 872020 7326217 MLBr_00730 Mycobacterium leprae Br4923 hypothetical protein YP_002503201.1 871766 R 561304 CDS YP_002503202.1 221229786 7326218 complement(872017..873666) 1 NC_011896.1 acetyl/propionyl CoA carboxylase subunit beta 873666 accD5 7326218 accD5 Mycobacterium leprae Br4923 acetyl/propionyl CoA carboxylase subunit beta YP_002503202.1 872017 R 561304 CDS YP_002503203.1 221229787 7327180 873729..874553 1 NC_011896.1 biotin apo-protein ligase 874553 birA 7327180 birA Mycobacterium leprae Br4923 biotin apo-protein ligase YP_002503203.1 873729 D 561304 CDS YP_002503204.1 221229788 7327265 874686..875204 1 NC_011896.1 hypothetical protein 875204 7327265 MLBr_00733 Mycobacterium leprae Br4923 hypothetical protein YP_002503204.1 874686 D 561304 CDS YP_002503205.1 221229789 7326219 complement(875159..875845) 1 NC_011896.1 hypothetical protein 875845 7326219 MLBr_00734 Mycobacterium leprae Br4923 hypothetical protein YP_002503205.1 875159 R 561304 CDS YP_002503206.1 221229790 7326220 875933..877252 1 NC_011896.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 877252 purK 7326220 purK Mycobacterium leprae Br4923 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002503206.1 875933 D 561304 CDS YP_002503207.1 221229791 7325039 877252..877767 1 NC_011896.1 phosphoribosylaminoimidazole carboxylase 877767 purE 7325039 purE Mycobacterium leprae Br4923 phosphoribosylaminoimidazole carboxylase YP_002503207.1 877252 D 561304 CDS YP_002503208.1 221229792 7325036 877862..879031 1 NC_011896.1 acyl-CoA dehydrogenase 879031 fadE25 7325036 fadE25 Mycobacterium leprae Br4923 acyl-CoA dehydrogenase YP_002503208.1 877862 D 561304 CDS YP_002503209.1 221229793 7326223 complement(888802..890979) 1 NC_011896.1 cation transport ATPase 890979 ctpC 7326223 ctpC Mycobacterium leprae Br4923 cation transport ATPase YP_002503209.1 888802 R 561304 CDS YP_002503210.1 221229794 7326138 complement(890990..891268) 1 NC_011896.1 hypothetical protein 891268 7326138 MLBr_00748 Mycobacterium leprae Br4923 hypothetical protein YP_002503210.1 890990 R 561304 CDS YP_002503211.1 221229795 7326225 complement(892072..893541) 1 NC_011896.1 hypothetical protein 893541 7326225 MLBr_00750 Mycobacterium leprae Br4923 hypothetical protein YP_002503211.1 892072 R 561304 CDS YP_002503212.1 221229796 7326226 893630..894565 1 NC_011896.1 dTDP-rhamnose modification protein 894565 rmlD 7326226 rmlD Mycobacterium leprae Br4923 dTDP-rhamnose modification protein YP_002503212.1 893630 D 561304 CDS YP_002503213.1 221229797 7326631 894558..895484 1 NC_011896.1 dTDP-rhamnosyl transferase 895484 wbbL 7326631 wbbL Mycobacterium leprae Br4923 dTDP-rhamnosyl transferase YP_002503213.1 894558 D 561304 CDS YP_002503214.1 221229798 7327314 895486..896562 1 NC_011896.1 sugar-phosphate nucleotidyl transferase 896562 rmlA2 7327314 rmlA2 Mycobacterium leprae Br4923 sugar-phosphate nucleotidyl transferase YP_002503214.1 895486 D 561304 CDS YP_002503215.1 221229799 7326227 complement(897502..897762) 1 NC_011896.1 hypothetical protein 897762 7326227 MLBr_00755 Mycobacterium leprae Br4923 hypothetical protein YP_002503215.1 897502 R 561304 CDS YP_002503216.1 221229800 7326228 complement(897980..899647) 1 NC_011896.1 DNA methylase 899647 7326228 MLBr_00756 Mycobacterium leprae Br4923 DNA methylase YP_002503216.1 897980 R 561304 CDS YP_002503217.1 221229801 7326229 complement(899669..900361) 1 NC_011896.1 hypothetical protein 900361 7326229 MLBr_00757 Mycobacterium leprae Br4923 hypothetical protein YP_002503217.1 899669 R 561304 CDS YP_002503218.1 221229802 7326230 complement(900402..901775) 1 NC_011896.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 901775 7326230 MLBr_00758 Mycobacterium leprae Br4923 F420-0--gamma-glutamyl ligase YP_002503218.1 900402 R 561304 CDS YP_002503219.1 221229803 7326231 complement(901772..902911) 1 NC_011896.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 902911 7326231 MLBr_00759 Mycobacterium leprae Br4923 LPPG:FO 2-phospho-L-lactate transferase YP_002503219.1 901772 R 561304 CDS YP_002503220.1 221229804 7326232 903236..903505 1 NC_011896.1 transcriptional regulator 903505 whiB2 7326232 whiB2 Mycobacterium leprae Br4923 transcriptional regulator YP_002503220.1 903236 D 561304 CDS YP_002503221.1 221229805 7327316 complement(903534..904037) 1 NC_011896.1 hypothetical protein 904037 7327316 MLBr_00761 Mycobacterium leprae Br4923 hypothetical protein YP_002503221.1 903534 R 561304 CDS YP_002503222.1 221229806 7326233 904077..904574 1 NC_011896.1 hypothetical protein 904574 7326233 MLBr_00762 Mycobacterium leprae Br4923 hypothetical protein YP_002503222.1 904077 D 561304 CDS YP_002503223.1 221229807 7326234 904684..906090 1 NC_011896.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 906090 manB 7326234 manB Mycobacterium leprae Br4923 phosphomannomutase YP_002503223.1 904684 D 561304 CDS YP_002503224.1 221229808 7324973 906087..907184 1 NC_011896.1 hypothetical protein 907184 7324973 MLBr_00764 Mycobacterium leprae Br4923 hypothetical protein YP_002503224.1 906087 D 561304 CDS YP_002503225.1 221229809 7326235 907192..908424 1 NC_011896.1 mannose-6-phosphate isomerase 908424 manA 7326235 manA Mycobacterium leprae Br4923 mannose-6-phosphate isomerase YP_002503225.1 907192 D 561304 CDS YP_002503226.1 221229810 7326240 913632..915110 1 NC_011896.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 915110 sahH 7326240 sahH Mycobacterium leprae Br4923 S-adenosyl-L-homocysteine hydrolase YP_002503226.1 913632 D 561304 CDS YP_002503227.1 221229811 7325965 915153..915785 1 NC_011896.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 915785 tmk 7325965 tmk Mycobacterium leprae Br4923 thymidylate kinase YP_002503227.1 915153 D 561304 CDS YP_002503228.1 221229812 7326028 915878..916564 1 NC_011896.1 two-component response regulator 916564 mtrA 7326028 mtrA Mycobacterium leprae Br4923 two-component response regulator YP_002503228.1 915878 D 561304 CDS YP_002503229.1 221229813 7324932 916692..918380 1 NC_011896.1 two-component system sensor kinase 918380 mtrB 7324932 mtrB Mycobacterium leprae Br4923 two-component system sensor kinase YP_002503229.1 916692 D 561304 CDS YP_002503230.1 221229814 7324933 918377..920146 1 NC_011896.1 lipoprotein LpqB 920146 lpqB 7324933 lpqB Mycobacterium leprae Br4923 lipoprotein LpqB YP_002503230.1 918377 D 561304 CDS YP_002503231.1 221229815 7325414 920267..920524 1 NC_011896.1 hypothetical protein 920524 7325414 MLBr_00776 Mycobacterium leprae Br4923 hypothetical protein YP_002503231.1 920267 D 561304 CDS YP_002503232.1 221229816 7326241 920664..920858 1 NC_011896.1 hypothetical protein 920858 7326241 MLBr_00777 Mycobacterium leprae Br4923 hypothetical protein YP_002503232.1 920664 D 561304 CDS YP_002503233.1 221229817 7326242 920962..921651 1 NC_011896.1 hypothetical protein 921651 7326242 MLBr_00778 Mycobacterium leprae Br4923 hypothetical protein YP_002503233.1 920962 D 561304 CDS YP_002503234.1 221229818 7326243 921731..924553 1 NC_011896.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 924553 secA 7326243 secA Mycobacterium leprae Br4923 preprotein translocase subunit SecA YP_002503234.1 921731 D 561304 CDS YP_002503235.1 221229819 7326244 925690..926172 1 NC_011896.1 hypothetical protein 926172 7326244 MLBr_00781 Mycobacterium leprae Br4923 hypothetical protein YP_002503235.1 925690 D 561304 CDS YP_002503236.1 221229820 7326245 926177..927334 1 NC_011896.1 transmembrane transport protein 927334 7326245 MLBr_00782 Mycobacterium leprae Br4923 transmembrane transport protein YP_002503236.1 926177 D 561304 CDS YP_002503237.1 221229821 7326253 complement(934537..935520) 1 NC_011896.1 hypothetical protein 935520 7326253 MLBr_00791 Mycobacterium leprae Br4923 hypothetical protein YP_002503237.1 934537 R 561304 CDS YP_002503238.1 221229822 7326254 complement(935517..936809) 1 NC_011896.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 936809 aroA 7326254 aroA Mycobacterium leprae Br4923 3-phosphoshikimate 1-carboxyvinyltransferase YP_002503238.1 935517 R 561304 CDS YP_002503239.1 221229823 7327230 936856..937614 1 NC_011896.1 bacteriophage protein 937614 7327230 MLBr_00793 Mycobacterium leprae Br4923 bacteriophage protein YP_002503239.1 936856 D 561304 CDS YP_002503240.1 221229824 7327254 942275..942451 1 NC_011896.1 hypothetical protein 942451 7327254 MLBr_00796 Mycobacterium leprae Br4923 hypothetical protein YP_002503240.1 942275 D 561304 CDS YP_002503241.1 221229825 7324990 complement(946534..948312) 1 NC_011896.1 hypothetical protein 948312 7324990 MLBr_00798 Mycobacterium leprae Br4923 hypothetical protein YP_002503241.1 946534 R 561304 CDS YP_002503242.1 221229826 7326258 complement(949061..949468) 1 NC_011896.1 hypothetical protein 949468 7326258 MLBr_00799 Mycobacterium leprae Br4923 hypothetical protein YP_002503242.1 949061 R 561304 CDS YP_002503243.1 221229827 7326262 951834..952073 1 NC_011896.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 952073 7326262 MLBr_00802 Mycobacterium leprae Br4923 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002503243.1 951834 D 561304 CDS YP_002503244.1 221229828 7326261 952123..953625 1 NC_011896.1 two-component system sensor kinase 953625 7326261 MLBr_00803 Mycobacterium leprae Br4923 two-component system sensor kinase YP_002503244.1 952123 D 561304 CDS YP_002503245.1 221229829 7326263 complement(953685..953939) 1 NC_011896.1 transcriptional regulator 953939 whiB1 7326263 whiB1 Mycobacterium leprae Br4923 transcriptional regulator YP_002503245.1 953685 R 561304 CDS YP_002503246.1 221229830 7326264 955226..955747 1 NC_011896.1 hypothetical protein 955747 7326264 MLBr_00806 Mycobacterium leprae Br4923 hypothetical protein YP_002503246.1 955226 D 561304 CDS YP_002503247.1 221229831 7326266 complement(956175..957908) 1 NC_011896.1 isochorismate synthase 957908 entC 7326266 entC Mycobacterium leprae Br4923 isochorismate synthase YP_002503247.1 956175 R 561304 CDS YP_002503248.1 221229832 7326267 complement(958903..960126) 1 NC_011896.1 hypothetical protein 960126 7326267 MLBr_00810 Mycobacterium leprae Br4923 hypothetical protein YP_002503248.1 958903 R 561304 CDS YP_002503249.1 221229833 7326268 complement(960138..961772) 1 NC_011896.1 ATP-dependent RNA helicase 961772 rhlE 7326268 rhlE Mycobacterium leprae Br4923 ATP-dependent RNA helicase YP_002503249.1 960138 R 561304 CDS YP_002503250.1 221229834 7326269 complement(962728..963315) 1 NC_011896.1 hypothetical protein 963315 7326269 MLBr_00813 Mycobacterium leprae Br4923 hypothetical protein YP_002503250.1 962728 R 561304 CDS YP_002503251.1 221229835 7326270 963614..963862 1 NC_011896.1 hypothetical protein 963862 7326270 MLBr_00814 Mycobacterium leprae Br4923 hypothetical protein YP_002503251.1 963614 D 561304 CDS YP_002503252.1 221229836 7326271 complement(963849..964535) 1 NC_011896.1 TetR family transcriptional regulator 964535 7326271 MLBr_00815 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002503252.1 963849 R 561304 CDS YP_002503253.1 221229837 7326272 964722..965747 1 NC_011896.1 hypothetical protein 965747 7326272 MLBr_00816 Mycobacterium leprae Br4923 hypothetical protein YP_002503253.1 964722 D 561304 CDS YP_002503254.1 221229838 7325050 965951..967138 1 NC_011896.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 967138 moeZ 7325050 moeZ Mycobacterium leprae Br4923 molybdopterin biosynthesis-like protein MoeZ YP_002503254.1 965951 D 561304 CDS YP_002503255.1 221229839 7324921 967193..968086 1 NC_011896.1 hypothetical protein 968086 7324921 MLBr_00818 Mycobacterium leprae Br4923 hypothetical protein YP_002503255.1 967193 D 561304 CDS YP_002503256.1 221229840 7325055 complement(977825..978220) 1 NC_011896.1 ferric uptake regulatory protein 978220 furB 7325055 furB Mycobacterium leprae Br4923 ferric uptake regulatory protein YP_002503256.1 977825 R 561304 CDS YP_002503257.1 221229841 7325056 978884..980275 1 NC_011896.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 980275 glyS 7325056 glyS Mycobacterium leprae Br4923 glycyl-tRNA synthetase YP_002503257.1 978884 D 561304 CDS YP_002503258.1 221229842 7325059 986517..987806 1 NC_011896.1 dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 987806 dgt 7325059 dgt Mycobacterium leprae Br4923 deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_002503258.1 986517 D 561304 CDS YP_002503259.1 221229843 7325060 988501..990429 1 NC_011896.1 synthesizes RNA primers at the replication forks; DNA primase 990429 dnaG 7325060 dnaG Mycobacterium leprae Br4923 DNA primase YP_002503259.1 988501 D 561304 CDS YP_002503260.1 221229844 7326178 complement(990444..990746) 1 NC_011896.1 hypothetical protein 990746 7326178 MLBr_00834 Mycobacterium leprae Br4923 hypothetical protein YP_002503260.1 990444 R 561304 CDS YP_002503261.1 221229845 7325062 993925..994308 1 NC_011896.1 hypothetical protein 994308 7325062 MLBr_00837 Mycobacterium leprae Br4923 hypothetical protein YP_002503261.1 993925 D 561304 CDS YP_002503262.1 221229846 7325063 complement(995713..996396) 1 NC_011896.1 serine acetyltransferase 996396 cysE 7325063 cysE Mycobacterium leprae Br4923 serine acetyltransferase YP_002503262.1 995713 R 561304 CDS YP_002503263.1 221229847 7326148 complement(996399..997331) 1 NC_011896.1 cysteine synthase 997331 cysK 7326148 cysK Mycobacterium leprae Br4923 cysteine synthase YP_002503263.1 996399 R 561304 CDS YP_002503264.1 221229848 7326150 complement(997328..998632) 1 NC_011896.1 hypothetical protein 998632 7326150 MLBr_00840 Mycobacterium leprae Br4923 hypothetical protein YP_002503264.1 997328 R 561304 CDS YP_002503265.1 221229849 7325064 999015..999938 1 NC_011896.1 major membrane protein I 999938 7325064 MLBr_00841 Mycobacterium leprae Br4923 major membrane protein I YP_002503265.1 999015 D 561304 CDS YP_002503266.1 221229850 7325065 1000594..1001829 1 NC_011896.1 hypothetical protein 1001829 7325065 MLBr_00842 Mycobacterium leprae Br4923 hypothetical protein YP_002503266.1 1000594 D 561304 CDS YP_002503267.1 221229851 7325410 1002602..1004155 1 NC_011896.1 nitrite extrusion protein 1004155 narK 7325410 narK Mycobacterium leprae Br4923 nitrite extrusion protein YP_002503267.1 1002602 D 561304 CDS YP_002503268.1 221229852 7324956 complement(1004143..1004724) 1 NC_011896.1 hypothetical protein 1004724 7324956 MLBr_00845 Mycobacterium leprae Br4923 hypothetical protein YP_002503268.1 1004143 R 561304 CDS YP_002503269.1 221229853 7325069 1005949..1008123 1 NC_011896.1 ABC transporter 1008123 7325069 MLBr_00848 Mycobacterium leprae Br4923 ABC transporter YP_002503269.1 1005949 D 561304 CDS YP_002503270.1 221229854 7325070 1008120..1008971 1 NC_011896.1 hypothetical protein 1008971 7325070 MLBr_00849 Mycobacterium leprae Br4923 hypothetical protein YP_002503270.1 1008120 D 561304 CDS YP_002503271.1 221229855 7325994 1012178..1013173 1 NC_011896.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1013173 ribF 7325994 ribF Mycobacterium leprae Br4923 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002503271.1 1012178 D 561304 CDS YP_002503272.1 221229856 7326622 1013291..1013560 1 NC_011896.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1013560 rpsO 7326622 rpsO Mycobacterium leprae Br4923 30S ribosomal protein S15 YP_002503272.1 1013291 D 561304 CDS YP_002503273.1 221229857 7325955 1013882..1016203 1 NC_011896.1 polynucleotide phosphorylase 1016203 gpsI 7325955 gpsI Mycobacterium leprae Br4923 polynucleotide phosphorylase YP_002503273.1 1013882 D 561304 CDS YP_002503274.1 221229858 7324656 1016292..1017566 1 NC_011896.1 zinc protease 1017566 pepR 7324656 pepR Mycobacterium leprae Br4923 zinc protease YP_002503274.1 1016292 D 561304 CDS YP_002503275.1 221229859 7325072 complement(1019733..1020485) 1 NC_011896.1 hypothetical protein 1020485 7325072 MLBr_00857 Mycobacterium leprae Br4923 hypothetical protein YP_002503275.1 1019733 R 561304 CDS YP_002503276.1 221229860 7325073 complement(1020512..1021456) 1 NC_011896.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1021456 lipA 7325073 lipA Mycobacterium leprae Br4923 lipoyl synthase YP_002503276.1 1020512 R 561304 CDS YP_002503277.1 221229861 7325387 complement(1021453..1022160) 1 NC_011896.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1022160 lipB 7325387 lipB Mycobacterium leprae Br4923 lipoate-protein ligase B YP_002503277.1 1021453 R 561304 CDS YP_002503278.1 221229862 7325388 complement(1022225..1023148) 1 NC_011896.1 hypothetical protein 1023148 7325388 MLBr_00860 Mycobacterium leprae Br4923 hypothetical protein YP_002503278.1 1022225 R 561304 CDS YP_002503279.1 221229863 7325074 complement(1023164..1024756) 1 NC_011896.1 dihydrolipoamide acetyltransferase 1024756 7325074 MLBr_00861 Mycobacterium leprae Br4923 dihydrolipoamide acetyltransferase YP_002503279.1 1023164 R 561304 CDS YP_002503280.1 221229864 7325075 1024996..1026786 1 NC_011896.1 short chain dehydrogenase 1026786 ephD 7325075 ephD Mycobacterium leprae Br4923 short chain dehydrogenase YP_002503280.1 1024996 D 561304 CDS YP_002503281.1 221229865 7325229 1026944..1027258 1 NC_011896.1 hypothetical protein 1027258 7325229 MLBr_00863 Mycobacterium leprae Br4923 hypothetical protein YP_002503281.1 1026944 D 561304 CDS YP_002503282.1 221229866 7325076 complement(1027329..1028903) 1 NC_011896.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1028903 pepA 7325076 pepA Mycobacterium leprae Br4923 leucyl aminopeptidase YP_002503282.1 1027329 R 561304 CDS YP_002503283.1 221229867 7327372 1029064..1030167 1 NC_011896.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 1030167 gcvT 7327372 gcvT Mycobacterium leprae Br4923 glycine cleavage system aminomethyltransferase T YP_002503283.1 1029064 D 561304 CDS YP_002503284.1 221229868 7325338 1030224..1031330 1 NC_011896.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1031330 ilvE 7325338 ilvE Mycobacterium leprae Br4923 branched-chain amino acid aminotransferase YP_002503284.1 1030224 D 561304 CDS YP_002503285.1 221229869 7326124 complement(1032099..1033154) 1 NC_011896.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1033154 cobT 7326124 cobT Mycobacterium leprae Br4923 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002503285.1 1032099 R 561304 CDS YP_002503286.1 221229870 7326125 complement(1033244..1033618) 1 NC_011896.1 hypothetical protein 1033618 7326125 MLBr_00869 Mycobacterium leprae Br4923 hypothetical protein YP_002503286.1 1033244 R 561304 CDS YP_002503287.1 221229871 7325078 1035267..1035623 1 NC_011896.1 hypothetical protein 1035623 7325078 MLBr_00871 Mycobacterium leprae Br4923 hypothetical protein YP_002503287.1 1035267 D 561304 CDS YP_002503288.1 221229872 7325079 complement(1035658..1036173) 1 NC_011896.1 hypothetical protein 1036173 7325079 MLBr_00872 Mycobacterium leprae Br4923 hypothetical protein YP_002503288.1 1035658 R 561304 CDS YP_002503289.1 221229873 7325080 1036492..1037466 1 NC_011896.1 carbohydrate kinase 1037466 7325080 MLBr_00873 Mycobacterium leprae Br4923 carbohydrate kinase YP_002503289.1 1036492 D 561304 CDS YP_002503290.1 221229874 7325081 complement(1037649..1039682) 1 NC_011896.1 asparagine synthetase 1039682 asnB 7325081 asnB Mycobacterium leprae Br4923 asparagine synthetase YP_002503290.1 1037649 R 561304 CDS YP_002503291.1 221229875 7327241 1039825..1040886 1 NC_011896.1 cytochrome C oxidase chain II 1040886 ctaC 7327241 ctaC Mycobacterium leprae Br4923 cytochrome C oxidase chain II YP_002503291.1 1039825 D 561304 CDS YP_002503292.1 221229876 7326134 1040939..1041358 1 NC_011896.1 hypothetical protein 1041358 7326134 MLBr_00876 Mycobacterium leprae Br4923 hypothetical protein YP_002503292.1 1040939 D 561304 CDS YP_002503293.1 221229877 7325082 1041545..1042426 1 NC_011896.1 hypothetical protein 1042426 mmpS3 7325082 mmpS3 Mycobacterium leprae Br4923 hypothetical protein YP_002503293.1 1041545 D 561304 CDS YP_002503294.1 221229878 7324908 1042426..1043064 1 NC_011896.1 hypothetical protein 1043064 7324908 MLBr_00878 Mycobacterium leprae Br4923 hypothetical protein YP_002503294.1 1042426 D 561304 CDS YP_002503295.1 221229879 7325083 complement(1043198..1044853) 1 NC_011896.1 cytochrome B 1044853 qcrB 7325083 qcrB Mycobacterium leprae Br4923 cytochrome B YP_002503295.1 1043198 R 561304 CDS YP_002503296.1 221229880 7326604 complement(1044850..1046034) 1 NC_011896.1 Rieske iron-sulfur reductase subunit 1046034 qcrA 7326604 qcrA Mycobacterium leprae Br4923 Rieske iron-sulfur reductase subunit YP_002503296.1 1044850 R 561304 CDS YP_002503297.1 221229881 7326603 complement(1046031..1046900) 1 NC_011896.1 cytochrome C reductase cytochrome C component 1046900 qcrC 7326603 qcrC Mycobacterium leprae Br4923 cytochrome C reductase cytochrome C component YP_002503297.1 1046031 R 561304 CDS YP_002503298.1 221229882 7326605 complement(1046962..1047570) 1 NC_011896.1 cytochrome C oxidase subunit III 1047570 ctaE 7326605 ctaE Mycobacterium leprae Br4923 cytochrome C oxidase subunit III YP_002503298.1 1046962 R 561304 CDS YP_002503299.1 221229883 7326135 1047707..1048807 1 NC_011896.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1048807 trpD 7326135 trpD Mycobacterium leprae Br4923 anthranilate phosphoribosyltransferase YP_002503299.1 1047707 D 561304 CDS YP_002503300.1 221229884 7325084 1051006..1052130 1 NC_011896.1 hypothetical protein 1052130 7325084 MLBr_00885 Mycobacterium leprae Br4923 hypothetical protein YP_002503300.1 1051006 D 561304 CDS YP_002503301.1 221229885 7325085 1052175..1053329 1 NC_011896.1 glycosyl transferase family protein 1053329 7325085 MLBr_00886 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002503301.1 1052175 D 561304 CDS YP_002503302.1 221229886 7325086 complement(1053326..1055128) 1 NC_011896.1 long-chain-fatty-acid-CoA ligase 1055128 7325086 MLBr_00887 Mycobacterium leprae Br4923 long-chain-fatty-acid-CoA ligase YP_002503302.1 1053326 R 561304 CDS YP_002503303.1 221229887 7325087 1055303..1055710 1 NC_011896.1 hypothetical protein 1055710 7325087 MLBr_00888 Mycobacterium leprae Br4923 hypothetical protein YP_002503303.1 1055303 D 561304 CDS YP_002503304.1 221229888 7325088 1055829..1056263 1 NC_011896.1 hypothetical protein 1056263 7325088 MLBr_00889 Mycobacterium leprae Br4923 hypothetical protein YP_002503304.1 1055829 D 561304 CDS YP_002503305.1 221229889 7325089 1056284..1057531 1 NC_011896.1 membrane transport ATPase 1057531 7325089 MLBr_00890 Mycobacterium leprae Br4923 membrane transport ATPase YP_002503305.1 1056284 D 561304 CDS YP_002503306.1 221229890 7325090 1057528..1057920 1 NC_011896.1 hypothetical protein 1057920 7325090 MLBr_00891 Mycobacterium leprae Br4923 hypothetical protein YP_002503306.1 1057528 D 561304 CDS YP_002503307.1 221229891 7325091 1058006..1058740 1 NC_011896.1 acyltransferase 1058740 7325091 MLBr_00892 Mycobacterium leprae Br4923 acyltransferase YP_002503307.1 1058006 D 561304 CDS YP_002503308.1 221229892 7325092 complement(1058748..1060034) 1 NC_011896.1 hypothetical protein 1060034 7325092 MLBr_00893 Mycobacterium leprae Br4923 hypothetical protein YP_002503308.1 1058748 R 561304 CDS YP_002503309.1 221229893 7325094 1061051..1061566 1 NC_011896.1 hypothetical protein 1061566 7325094 MLBr_00895 Mycobacterium leprae Br4923 hypothetical protein YP_002503309.1 1061051 D 561304 CDS YP_002503310.1 221229894 7325095 1061630..1063018 1 NC_011896.1 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 1063018 aroG 7325095 aroG Mycobacterium leprae Br4923 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase YP_002503310.1 1061630 D 561304 CDS YP_002503311.1 221229895 7327235 complement(1063031..1064233) 1 NC_011896.1 serine-threonine protein kinase 1064233 7327235 MLBr_00897 Mycobacterium leprae Br4923 serine-threonine protein kinase YP_002503311.1 1063031 R 561304 CDS YP_002503312.1 221229896 7325096 1064386..1064790 1 NC_011896.1 DNA-binding protein 1064790 7325096 MLBr_00898 Mycobacterium leprae Br4923 DNA-binding protein YP_002503312.1 1064386 D 561304 CDS YP_002503313.1 221229897 7325097 complement(1064787..1066304) 1 NC_011896.1 integral-membrane protein 1066304 7325097 MLBr_00899 Mycobacterium leprae Br4923 integral-membrane protein YP_002503313.1 1064787 R 561304 CDS YP_002503314.1 221229898 7324705 1067643..1068557 1 NC_011896.1 hypothetical protein 1068557 7324705 MLBr_00901 Mycobacterium leprae Br4923 hypothetical protein YP_002503314.1 1067643 D 561304 CDS YP_002503315.1 221229899 7325099 complement(1068554..1069273) 1 NC_011896.1 lipoprotein 1069273 7325099 MLBr_00902 Mycobacterium leprae Br4923 lipoprotein YP_002503315.1 1068554 R 561304 CDS YP_002503316.1 221229900 7325100 complement(1069345..1069977) 1 NC_011896.1 hypothetical protein 1069977 7325100 MLBr_00903 Mycobacterium leprae Br4923 hypothetical protein YP_002503316.1 1069345 R 561304 CDS YP_002503317.1 221229901 7325101 1070294..1070698 1 NC_011896.1 hypothetical protein 1070698 7325101 MLBr_00904 Mycobacterium leprae Br4923 hypothetical protein YP_002503317.1 1070294 D 561304 CDS YP_002503318.1 221229902 7325102 1071071..1071502 1 NC_011896.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1071502 7325102 MLBr_00905 Mycobacterium leprae Br4923 cell division protein MraZ YP_002503318.1 1071071 D 561304 CDS YP_002503319.1 221229903 7325103 1071630..1072748 1 NC_011896.1 S-adenosyl-methyltransferase MraW 1072748 mraW 7325103 mraW Mycobacterium leprae Br4923 S-adenosyl-methyltransferase MraW YP_002503319.1 1071630 D 561304 CDS YP_002503320.1 221229904 7325104 1072745..1073878 1 NC_011896.1 hypothetical protein 1073878 7325104 MLBr_00907 Mycobacterium leprae Br4923 hypothetical protein YP_002503320.1 1072745 D 561304 CDS YP_002503321.1 221229905 7325105 1073875..1075902 1 NC_011896.1 penicillin-binding protein 2 1075902 pbpB 7325105 pbpB Mycobacterium leprae Br4923 penicillin-binding protein 2 YP_002503321.1 1073875 D 561304 CDS YP_002503322.1 221229906 7327355 1076044..1077636 1 NC_011896.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1077636 murE 7327355 murE Mycobacterium leprae Br4923 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002503322.1 1076044 D 561304 CDS YP_002503323.1 221229907 7324938 1077633..1079186 1 NC_011896.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) 1079186 murF 7324938 murF Mycobacterium leprae Br4923 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) YP_002503323.1 1077633 D 561304 CDS YP_002503324.1 221229908 7324939 1079183..1080262 1 NC_011896.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1080262 mraY 7324939 mraY Mycobacterium leprae Br4923 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002503324.1 1079183 D 561304 CDS YP_002503325.1 221229909 7324927 1080264..1081736 1 NC_011896.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1081736 murD 7324927 murD Mycobacterium leprae Br4923 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002503325.1 1080264 D 561304 CDS YP_002503326.1 221229910 7324937 1081743..1083347 1 NC_011896.1 cell division protein FtsW 1083347 ftsW 7324937 ftsW Mycobacterium leprae Br4923 cell division protein FtsW YP_002503326.1 1081743 D 561304 CDS YP_002503327.1 221229911 7325315 1083344..1084567 1 NC_011896.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 1084567 murG 7325315 murG Mycobacterium leprae Br4923 UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase YP_002503327.1 1083344 D 561304 CDS YP_002503328.1 221229912 7324940 1084564..1086051 1 NC_011896.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1086051 murC 7324940 murC Mycobacterium leprae Br4923 UDP-N-acetylmuramate--L-alanine ligase YP_002503328.1 1084564 D 561304 CDS YP_002503329.1 221229913 7324936 1086048..1087073 1 NC_011896.1 FtsQ-family protein 1087073 7324936 MLBr_00916 Mycobacterium leprae Br4923 FtsQ-family protein YP_002503329.1 1086048 D 561304 CDS YP_002503330.1 221229914 7325106 1087339..1088478 1 NC_011896.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1088478 ftsZ 7325106 ftsZ Mycobacterium leprae Br4923 cell division protein FtsZ YP_002503330.1 1087339 D 561304 CDS YP_002503331.1 221229915 7325317 1088501..1089250 1 NC_011896.1 hypothetical protein 1089250 7325317 MLBr_00918 Mycobacterium leprae Br4923 hypothetical protein YP_002503331.1 1088501 D 561304 CDS YP_002503332.1 221229916 7325107 1089247..1090029 1 NC_011896.1 DNA-binding protein 1090029 7325107 MLBr_00919 Mycobacterium leprae Br4923 DNA-binding protein YP_002503332.1 1089247 D 561304 CDS YP_002503333.1 221229917 7325108 1090097..1090729 1 NC_011896.1 hypothetical protein 1090729 7325108 MLBr_00920 Mycobacterium leprae Br4923 hypothetical protein YP_002503333.1 1090097 D 561304 CDS YP_002503334.1 221229918 7325109 1090854..1091144 1 NC_011896.1 hypothetical protein 1091144 7325109 MLBr_00921 Mycobacterium leprae Br4923 hypothetical protein YP_002503334.1 1090854 D 561304 CDS YP_002503335.1 221229919 7325110 1091391..1092191 1 NC_011896.1 hypothetical protein 1092191 ag84 7325110 ag84 Mycobacterium leprae Br4923 hypothetical protein YP_002503335.1 1091391 D 561304 CDS YP_002503336.1 221229920 7327194 1092264..1092656 1 NC_011896.1 hypothetical protein 1092656 7327194 MLBr_00923 Mycobacterium leprae Br4923 hypothetical protein YP_002503336.1 1092264 D 561304 CDS YP_002503337.1 221229921 7325112 1094419..1095855 1 NC_011896.1 glutamine synthase class I 1095855 glnA 7325112 glnA Mycobacterium leprae Br4923 glutamine synthase class I YP_002503337.1 1094419 D 561304 CDS YP_002503338.1 221229922 7325349 complement(1096107..1096475) 1 NC_011896.1 hypothetical protein 1096475 7325349 MLBr_00926 Mycobacterium leprae Br4923 hypothetical protein YP_002503338.1 1096107 R 561304 CDS YP_002503339.1 221229923 7325113 complement(1096567..1096875) 1 NC_011896.1 hypothetical protein 1096875 7325113 MLBr_00927 Mycobacterium leprae Br4923 hypothetical protein YP_002503339.1 1096567 R 561304 CDS YP_002503340.1 221229924 7325114 1098096..1098380 1 NC_011896.1 hypothetical protein 1098380 7325114 MLBr_00928 Mycobacterium leprae Br4923 hypothetical protein YP_002503340.1 1098096 D 561304 CDS YP_002503341.1 221229925 7325123 1109935..1110231 1 NC_011896.1 hypothetical protein 1110231 7325123 MLBr_00938 Mycobacterium leprae Br4923 hypothetical protein YP_002503341.1 1109935 D 561304 CDS YP_002503342.1 221229926 7325124 1110228..1110470 1 NC_011896.1 hypothetical protein 1110470 7325124 MLBr_00939 Mycobacterium leprae Br4923 hypothetical protein YP_002503342.1 1110228 D 561304 CDS YP_002503343.1 221229927 7325129 1116273..1116650 1 NC_011896.1 hypothetical protein 1116650 7325129 MLBr_00946 Mycobacterium leprae Br4923 hypothetical protein YP_002503343.1 1116273 D 561304 CDS YP_002503344.1 221229928 7325130 complement(1117561..1117818) 1 NC_011896.1 hypothetical protein 1117818 7325130 MLBr_00947 Mycobacterium leprae Br4923 hypothetical protein YP_002503344.1 1117561 R 561304 CDS YP_002503345.1 221229929 7326685 complement(1118771..1119184) 1 NC_011896.1 hypothetical protein 1119184 7326685 MLBr_00949 Mycobacterium leprae Br4923 hypothetical protein YP_002503345.1 1118771 R 561304 CDS YP_002503346.1 221229930 7326686 complement(1119196..1119396) 1 NC_011896.1 hypothetical protein 1119396 7326686 MLBr_00950 Mycobacterium leprae Br4923 hypothetical protein YP_002503346.1 1119196 R 561304 CDS YP_002503347.1 221229931 7326689 1121934..1122173 1 NC_011896.1 hypothetical protein 1122173 7326689 MLBr_00953 Mycobacterium leprae Br4923 hypothetical protein YP_002503347.1 1121934 D 561304 CDS YP_002503348.1 221229932 7326691 complement(1123058..1124863) 1 NC_011896.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1124863 ppdK 7326691 ppdK Mycobacterium leprae Br4923 pyruvate phosphate dikinase YP_002503348.1 1123058 R 561304 CDS YP_002503349.1 221229933 7324985 1124908..1125417 1 NC_011896.1 integral membrane protein 1125417 7324985 MLBr_00956 Mycobacterium leprae Br4923 integral membrane protein YP_002503349.1 1124908 D 561304 CDS YP_002503350.1 221229934 7326692 complement(1125895..1126269) 1 NC_011896.1 hypothetical protein 1126269 7326692 MLBr_00957 Mycobacterium leprae Br4923 hypothetical protein YP_002503350.1 1125895 R 561304 CDS YP_002503351.1 221229935 7326693 1126280..1126711 1 NC_011896.1 hypothetical protein 1126711 7326693 MLBr_00958 Mycobacterium leprae Br4923 hypothetical protein YP_002503351.1 1126280 D 561304 CDS YP_002503352.1 221229936 7326694 1126953..1127306 1 NC_011896.1 hypothetical protein 1127306 7326694 MLBr_00959 Mycobacterium leprae Br4923 hypothetical protein YP_002503352.1 1126953 D 561304 CDS YP_002503353.1 221229937 7326696 complement(1127818..1130100) 1 NC_011896.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1130100 metE 7326696 metE Mycobacterium leprae Br4923 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_002503353.1 1127818 R 561304 CDS YP_002503354.1 221229938 7326697 1131339..1131803 1 NC_011896.1 hypothetical protein 1131803 7326697 MLBr_00963 Mycobacterium leprae Br4923 hypothetical protein YP_002503354.1 1131339 D 561304 CDS YP_002503355.1 221229939 7326698 1131841..1132098 1 NC_011896.1 hypothetical protein 1132098 7326698 MLBr_00964 Mycobacterium leprae Br4923 hypothetical protein YP_002503355.1 1131841 D 561304 CDS YP_002503356.1 221229940 7326711 1144536..1147196 1 NC_011896.1 Cell division protein 1147196 ftsK 7326711 ftsK Mycobacterium leprae Br4923 Cell division protein YP_002503356.1 1144536 D 561304 CDS YP_002503357.1 221229941 7325314 complement(1147206..1147748) 1 NC_011896.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 1147748 7325314 MLBr_00978 Mycobacterium leprae Br4923 N-acetylglutamate synthase YP_002503357.1 1147206 R 561304 CDS YP_002503358.1 221229942 7326712 1147815..1148396 1 NC_011896.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1148396 7326712 MLBr_00979 Mycobacterium leprae Br4923 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002503358.1 1147815 D 561304 CDS YP_002503359.1 221229943 7326717 complement(1151064..>1151513) 1 NC_011896.1 hypothetical protein >1151513 7326717 MLBr_00984 Mycobacterium leprae Br4923 hypothetical protein YP_002503359.1 1151064 R 561304 CDS YP_002503360.1 221229944 7326718 1151550..1152728 1 NC_011896.1 glycosyltransferase 1152728 7326718 MLBr_00985 Mycobacterium leprae Br4923 glycosyltransferase YP_002503360.1 1151550 D 561304 CDS YP_002503361.1 221229945 7326719 1152742..1152945 1 NC_011896.1 hypothetical protein 1152945 7326719 MLBr_00986 Mycobacterium leprae Br4923 hypothetical protein YP_002503361.1 1152742 D 561304 CDS YP_002503362.1 221229946 7326720 1153096..1155231 1 NC_011896.1 recombinase A 1155231 recA 7326720 recA Mycobacterium leprae Br4923 recombinase A YP_002503362.1 1153096 D 561304 CDS YP_002503363.1 221229947 7326609 1155197..1155712 1 NC_011896.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1155712 recX 7326609 recX Mycobacterium leprae Br4923 recombination regulator RecX YP_002503363.1 1155197 D 561304 CDS YP_002503364.1 221229948 7326614 1155771..1157324 1 NC_011896.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1157324 7326614 MLBr_00989 Mycobacterium leprae Br4923 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002503364.1 1155771 D 561304 CDS YP_002503365.1 221229949 7326721 1157321..1157950 1 NC_011896.1 hypothetical protein 1157950 7326721 MLBr_00990 Mycobacterium leprae Br4923 hypothetical protein YP_002503365.1 1157321 D 561304 CDS YP_002503366.1 221229950 7326725 1162660..1163358 1 NC_011896.1 hypothetical protein 1163358 7326725 MLBr_00994 Mycobacterium leprae Br4923 hypothetical protein YP_002503366.1 1162660 D 561304 CDS YP_002503367.1 221229951 7326726 1163355..1164290 1 NC_011896.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1164290 miaA 7326726 miaA Mycobacterium leprae Br4923 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002503367.1 1163355 D 561304 CDS YP_002503368.1 221229952 7324901 1164357..1165247 1 NC_011896.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1165247 dapF 7324901 dapF Mycobacterium leprae Br4923 diaminopimelate epimerase YP_002503368.1 1164357 D 561304 CDS YP_002503369.1 221229953 7326161 1165310..1166776 1 NC_011896.1 ATP/GTP-binding protein 1166776 7326161 MLBr_00997 Mycobacterium leprae Br4923 ATP/GTP-binding protein YP_002503369.1 1165310 D 561304 CDS YP_002503370.1 221229954 7326730 complement(1172639..1172914) 1 NC_011896.1 hypothetical protein 1172914 7326730 MLBr_01001 Mycobacterium leprae Br4923 hypothetical protein YP_002503370.1 1172639 R 561304 CDS YP_002503371.1 221229955 7326731 1172959..1175022 1 NC_011896.1 hypothetical protein 1175022 7326731 MLBr_01002 Mycobacterium leprae Br4923 hypothetical protein YP_002503371.1 1172959 D 561304 CDS YP_002503372.1 221229956 7326732 complement(1175061..1175768) 1 NC_011896.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 1175768 lexA 7326732 lexA Mycobacterium leprae Br4923 LexA repressor YP_002503372.1 1175061 R 561304 CDS YP_002503373.1 221229957 7325383 1176048..1176542 1 NC_011896.1 hypothetical protein 1176542 7325383 MLBr_01004 Mycobacterium leprae Br4923 hypothetical protein YP_002503373.1 1176048 D 561304 CDS YP_002503374.1 221229958 7326733 1176704..1177168 1 NC_011896.1 transcriptional regulator NrdR 1177168 nrdR 7326733 nrdR Mycobacterium leprae Br4923 transcriptional regulator NrdR YP_002503374.1 1176704 D 561304 CDS YP_002503375.1 221229959 7326734 1177210..1177695 1 NC_011896.1 hypothetical protein 1177695 7326734 MLBr_01006 Mycobacterium leprae Br4923 hypothetical protein YP_002503375.1 1177210 D 561304 CDS YP_002503376.1 221229960 7326737 complement(1179559..1180539) 1 NC_011896.1 hypothetical protein 1180539 7326737 MLBr_01009 Mycobacterium leprae Br4923 hypothetical protein YP_002503376.1 1179559 R 561304 CDS YP_002503377.1 221229961 7326738 complement(1180816..1181058) 1 NC_011896.1 hypothetical protein 1181058 7326738 MLBr_01010 Mycobacterium leprae Br4923 hypothetical protein YP_002503377.1 1180816 R 561304 CDS YP_002503378.1 221229962 7326739 complement(1181098..1181520) 1 NC_011896.1 hypothetical protein 1181520 7326739 MLBr_01011 Mycobacterium leprae Br4923 hypothetical protein YP_002503378.1 1181098 R 561304 CDS YP_002503379.1 221229963 7326741 complement(1183521..1184213) 1 NC_011896.1 iron dependent repressor 1184213 7326741 MLBr_01013 Mycobacterium leprae Br4923 iron dependent repressor YP_002503379.1 1183521 R 561304 CDS YP_002503380.1 221229964 7326742 complement(1184370..1185329) 1 NC_011896.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 1185329 7326742 MLBr_01014 Mycobacterium leprae Br4923 RNA polymerase sigma factor SigB YP_002503380.1 1184370 R 561304 CDS YP_002503381.1 221229965 7326743 complement(1185496..1185915) 1 NC_011896.1 hypothetical protein 1185915 7326743 MLBr_01015 Mycobacterium leprae Br4923 hypothetical protein YP_002503381.1 1185496 R 561304 CDS YP_002503382.1 221229966 7326744 1185943..1186266 1 NC_011896.1 hypothetical protein 1186266 7326744 MLBr_01016 Mycobacterium leprae Br4923 hypothetical protein YP_002503382.1 1185943 D 561304 CDS YP_002503383.1 221229967 7326745 complement(1186253..1187245) 1 NC_011896.1 hypothetical protein 1187245 7326745 MLBr_01017 Mycobacterium leprae Br4923 hypothetical protein YP_002503383.1 1186253 R 561304 CDS YP_002503384.1 221229968 7326746 complement(1187250..1187465) 1 NC_011896.1 hypothetical protein 1187465 7326746 MLBr_01018 Mycobacterium leprae Br4923 hypothetical protein YP_002503384.1 1187250 R 561304 CDS YP_002503385.1 221229969 7326750 complement(1189225..1190949) 1 NC_011896.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 1190949 rpoT 7326750 rpoT Mycobacterium leprae Br4923 RNA polymerase sigma factor YP_002503385.1 1189225 R 561304 CDS YP_002503386.1 221229970 7326676 complement(1190960..1191934) 1 NC_011896.1 polyphosphate glucokinase 1191934 ppgK 7326676 ppgK Mycobacterium leprae Br4923 polyphosphate glucokinase YP_002503386.1 1190960 R 561304 CDS YP_002503387.1 221229971 7324999 1191883..1192758 1 NC_011896.1 inositol monophosphatase 1192758 suhB 7324999 suhB Mycobacterium leprae Br4923 inositol monophosphatase YP_002503387.1 1191883 D 561304 CDS YP_002503388.1 221229972 7326008 complement(1192762..1193412) 1 NC_011896.1 hypothetical protein 1193412 7326008 MLBr_01025 Mycobacterium leprae Br4923 hypothetical protein YP_002503388.1 1192762 R 561304 CDS YP_002503389.1 221229973 7326751 1193608..1193910 1 NC_011896.1 hypothetical protein 1193910 7326751 MLBr_01026 Mycobacterium leprae Br4923 hypothetical protein YP_002503389.1 1193608 D 561304 CDS YP_002503390.1 221229974 7326752 complement(1193915..1194388) 1 NC_011896.1 hypothetical protein 1194388 7326752 MLBr_01027 Mycobacterium leprae Br4923 hypothetical protein YP_002503390.1 1193915 R 561304 CDS YP_002503391.1 221229975 7326753 1194414..1194878 1 NC_011896.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1194878 dut 7326753 dut Mycobacterium leprae Br4923 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002503391.1 1194414 D 561304 CDS YP_002503392.1 221229976 7326188 1194875..1195696 1 NC_011896.1 hypothetical protein 1195696 7326188 MLBr_01029 Mycobacterium leprae Br4923 hypothetical protein YP_002503392.1 1194875 D 561304 CDS YP_002503393.1 221229977 7326754 complement(1195741..1196439) 1 NC_011896.1 hypothetical protein 1196439 7326754 MLBr_01030 Mycobacterium leprae Br4923 hypothetical protein YP_002503393.1 1195741 R 561304 CDS YP_002503394.1 221229978 7326760 complement(1199277..1200566) 1 NC_011896.1 membrane transport protein 1200566 7326760 MLBr_01036 Mycobacterium leprae Br4923 membrane transport protein YP_002503394.1 1199277 R 561304 CDS YP_002503395.1 221229979 7326761 complement(1200619..1201173) 1 NC_011896.1 hypothetical protein 1201173 7326761 MLBr_01037 Mycobacterium leprae Br4923 hypothetical protein YP_002503395.1 1200619 R 561304 CDS YP_002503396.1 221229980 7326762 1201255..1203186 1 NC_011896.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1203186 dxs 7326762 dxs Mycobacterium leprae Br4923 1-deoxy-D-xylulose-5-phosphate synthase YP_002503396.1 1201255 D 561304 CDS YP_002503397.1 221229981 7326763 complement(1205287..1206576) 1 NC_011896.1 hypothetical protein 1206576 7326763 MLBr_01040 Mycobacterium leprae Br4923 hypothetical protein YP_002503397.1 1205287 R 561304 CDS YP_002503398.1 221229982 7326764 complement(1206578..1207168) 1 NC_011896.1 hypothetical protein 1207168 7326764 MLBr_01041 Mycobacterium leprae Br4923 hypothetical protein YP_002503398.1 1206578 R 561304 CDS YP_002503399.1 221229983 7326521 1208257..1209330 1 NC_011896.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1209330 hemE 7326521 hemE Mycobacterium leprae Br4923 uroporphyrinogen decarboxylase YP_002503399.1 1208257 D 561304 CDS YP_002503400.1 221229984 7324674 1209327..1210682 1 NC_011896.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 1210682 hemY 7324674 hemY Mycobacterium leprae Br4923 protoporphyrinogen oxidase YP_002503400.1 1209327 D 561304 CDS YP_002503401.1 221229985 7324676 1210688..1211383 1 NC_011896.1 hypothetical protein 1211383 7324676 MLBr_01045 Mycobacterium leprae Br4923 hypothetical protein YP_002503401.1 1210688 D 561304 CDS YP_002503402.1 221229986 7326527 1217149..1218579 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1218579 xclC 7326527 xclC Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002503402.1 1217149 D 561304 CDS YP_002503403.1 221229987 7327319 complement(1218602..1219867) 1 NC_011896.1 hypothetical protein 1219867 7327319 MLBr_01052 Mycobacterium leprae Br4923 hypothetical protein YP_002503403.1 1218602 R 561304 CDS YP_002503404.1 221229988 7326528 1220414..1220713 1 NC_011896.1 hypothetical protein 1220713 7326528 MLBr_01053 Mycobacterium leprae Br4923 hypothetical protein YP_002503404.1 1220414 D 561304 CDS YP_002503405.1 221229989 7326530 1221473..1221775 1 NC_011896.1 hypothetical protein 1221775 7326530 MLBr_01055 Mycobacterium leprae Br4923 hypothetical protein YP_002503405.1 1221473 D 561304 CDS YP_002503406.1 221229990 7326531 1221827..1222114 1 NC_011896.1 hypothetical protein 1222114 7326531 MLBr_01056 Mycobacterium leprae Br4923 hypothetical protein YP_002503406.1 1221827 D 561304 CDS YP_002503407.1 221229991 7326532 1222289..1222642 1 NC_011896.1 hypothetical protein 1222642 7326532 MLBr_01057 Mycobacterium leprae Br4923 hypothetical protein YP_002503407.1 1222289 D 561304 CDS YP_002503408.1 221229992 7326533 complement(1222733..1223686) 1 NC_011896.1 transferase 1223686 7326533 MLBr_01058 Mycobacterium leprae Br4923 transferase YP_002503408.1 1222733 R 561304 CDS YP_002503409.1 221229993 7326534 1223740..1224804 1 NC_011896.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1224804 dapE 7326534 dapE Mycobacterium leprae Br4923 succinyl-diaminopimelate desuccinylase YP_002503409.1 1223740 D 561304 CDS YP_002503410.1 221229994 7326535 1226482..1227045 1 NC_011896.1 hypothetical protein 1227045 7326535 MLBr_01061 Mycobacterium leprae Br4923 hypothetical protein YP_002503410.1 1226482 D 561304 CDS YP_002503411.1 221229995 7325260 1228816..1229691 1 NC_011896.1 dihydropteroate synthase 1229691 folP2 7325260 folP2 Mycobacterium leprae Br4923 dihydropteroate synthase YP_002503411.1 1228816 D 561304 CDS YP_002503412.1 221229996 7325307 1229688..1230668 1 NC_011896.1 glucosyl-3-phosphoglycerate synthase 1230668 7325307 MLBr_01064 Mycobacterium leprae Br4923 glucosyl-3-phosphoglycerate synthase YP_002503412.1 1229688 D 561304 CDS YP_002503413.1 221229997 7326537 1230684..1231028 1 NC_011896.1 hypothetical protein 1231028 7326537 MLBr_01065 Mycobacterium leprae Br4923 hypothetical protein YP_002503413.1 1230684 D 561304 CDS YP_002503414.1 221229998 7326538 1231025..1231603 1 NC_011896.1 DNA-3-methyladenine glycosidase I 1231603 tagA 7326538 tagA Mycobacterium leprae Br4923 DNA-3-methyladenine glycosidase I YP_002503414.1 1231025 D 561304 CDS YP_002503415.1 221229999 7326009 1231817..1232044 1 NC_011896.1 hypothetical protein 1232044 7326009 MLBr_01067 Mycobacterium leprae Br4923 hypothetical protein YP_002503415.1 1231817 D 561304 CDS YP_002503416.1 221230000 7326540 1233389..1234603 1 NC_011896.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1234603 glgC 7326540 glgC Mycobacterium leprae Br4923 glucose-1-phosphate adenylyltransferase YP_002503416.1 1233389 D 561304 CDS YP_002503417.1 221230001 7325344 1234677..1235330 1 NC_011896.1 TetR family transcriptional regulator 1235330 7325344 MLBr_01070 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002503417.1 1234677 D 561304 CDS YP_002503418.1 221230002 7326545 complement(1238426..1239100) 1 NC_011896.1 O-methyltransferase 1239100 7326545 MLBr_01075 Mycobacterium leprae Br4923 O-methyltransferase YP_002503418.1 1238426 R 561304 CDS YP_002503419.1 221230003 7326546 1239380..1240171 1 NC_011896.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1240171 sigE 7326546 sigE Mycobacterium leprae Br4923 RNA polymerase sigma factor SigE YP_002503419.1 1239380 D 561304 CDS YP_002503420.1 221230004 7325987 1240318..1240737 1 NC_011896.1 hypothetical protein 1240737 7325987 MLBr_01077 Mycobacterium leprae Br4923 hypothetical protein YP_002503420.1 1240318 D 561304 CDS YP_002503421.1 221230005 7326547 1240812..1242413 1 NC_011896.1 serine protease 1242413 htrA 7326547 htrA Mycobacterium leprae Br4923 serine protease YP_002503421.1 1240812 D 561304 CDS YP_002503422.1 221230006 7324701 1242413..1242775 1 NC_011896.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1242775 7324701 MLBr_01079 Mycobacterium leprae Br4923 sec-independent translocase YP_002503422.1 1242413 D 561304 CDS YP_002503423.1 221230007 7326548 complement(1243795..1244946) 1 NC_011896.1 MRP-family ATP-binding protein 1244946 mrp 7326548 mrp Mycobacterium leprae Br4923 MRP-family ATP-binding protein YP_002503423.1 1243795 R 561304 CDS YP_002503424.1 221230008 7326553 1248365..1249771 1 NC_011896.1 solute-binding transport lipoprotein 1249771 7326553 MLBr_01086 Mycobacterium leprae Br4923 solute-binding transport lipoprotein YP_002503424.1 1248365 D 561304 CDS YP_002503425.1 221230009 7326554 1249800..1250714 1 NC_011896.1 ABC transporter inner membrane protein 1250714 7326554 MLBr_01087 Mycobacterium leprae Br4923 ABC transporter inner membrane protein YP_002503425.1 1249800 D 561304 CDS YP_002503426.1 221230010 7326555 1250704..1251567 1 NC_011896.1 ABC transporter inner membrane protein 1251567 7326555 MLBr_01088 Mycobacterium leprae Br4923 ABC transporter inner membrane protein YP_002503426.1 1250704 D 561304 CDS YP_002503427.1 221230011 7326556 1251572..1252750 1 NC_011896.1 ABC transporter ATP-binding protein 1252750 7326556 MLBr_01089 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503427.1 1251572 D 561304 CDS YP_002503428.1 221230012 7326557 complement(1253379..1254488) 1 NC_011896.1 membrane transport protein 1254488 7326557 MLBr_01090 Mycobacterium leprae Br4923 membrane transport protein YP_002503428.1 1253379 R 561304 CDS YP_002503429.1 221230013 7326558 1254711..1255700 1 NC_011896.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1255700 mdh 7326558 mdh Mycobacterium leprae Br4923 malate dehydrogenase YP_002503429.1 1254711 D 561304 CDS YP_002503430.1 221230014 7326559 1257769..1258626 1 NC_011896.1 lipoprotein 1258626 7326559 MLBr_01093 Mycobacterium leprae Br4923 lipoprotein YP_002503430.1 1257769 D 561304 CDS YP_002503431.1 221230015 7326560 complement(1259172..1260005) 1 NC_011896.1 short chain alcohol dehydrogenase 1260005 7326560 MLBr_01094 Mycobacterium leprae Br4923 short chain alcohol dehydrogenase YP_002503431.1 1259172 R 561304 CDS YP_002503432.1 221230016 7326561 complement(1260068..1263850) 1 NC_011896.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 1263850 kgd 7326561 kgd Mycobacterium leprae Br4923 alpha-ketoglutarate decarboxylase YP_002503432.1 1260068 R 561304 CDS YP_002503433.1 221230017 7327337 complement(1263972..1264646) 1 NC_011896.1 hypothetical protein 1264646 7327337 MLBr_01096 Mycobacterium leprae Br4923 hypothetical protein YP_002503433.1 1263972 R 561304 CDS YP_002503434.1 221230018 7326563 complement(1266688..1270146) 1 NC_011896.1 hypothetical protein 1270146 7326563 MLBr_01098 Mycobacterium leprae Br4923 hypothetical protein YP_002503434.1 1266688 R 561304 CDS YP_002503435.1 221230019 7326564 complement(1270197..1270805) 1 NC_011896.1 lipoprotein 1270805 7326564 MLBr_01099 Mycobacterium leprae Br4923 lipoprotein YP_002503435.1 1270197 R 561304 CDS YP_002503436.1 221230020 7326566 1272672..1273811 1 NC_011896.1 acyltransferase 1273811 7326566 MLBr_01101 Mycobacterium leprae Br4923 acyltransferase YP_002503436.1 1272672 D 561304 CDS YP_002503437.1 221230021 7326568 complement(1276498..1277859) 1 NC_011896.1 oxidoreductase subunit 1277859 7326568 MLBr_01103 Mycobacterium leprae Br4923 oxidoreductase subunit YP_002503437.1 1276498 R 561304 CDS YP_002503438.1 221230022 7326570 1279302..1279991 1 NC_011896.1 hypothetical protein 1279991 7326570 MLBr_01105 Mycobacterium leprae Br4923 hypothetical protein YP_002503438.1 1279302 D 561304 CDS YP_002503439.1 221230023 7326571 1280466..1280807 1 NC_011896.1 hypothetical protein 1280807 7326571 MLBr_01106 Mycobacterium leprae Br4923 hypothetical protein YP_002503439.1 1280466 D 561304 CDS YP_002503440.1 221230024 7326578 complement(1287777..1289666) 1 NC_011896.1 ABC transporter ATP-binding protein 1289666 7326578 MLBr_01113 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503440.1 1287777 R 561304 CDS YP_002503441.1 221230025 7326579 complement(1289663..1291417) 1 NC_011896.1 ABC transporter protein, ATP-binding component 1291417 7326579 MLBr_01114 Mycobacterium leprae Br4923 ABC transporter protein, ATP-binding component YP_002503441.1 1289663 R 561304 CDS YP_002503442.1 221230026 7326580 1291603..1292169 1 NC_011896.1 lipoprotein 1292169 7326580 MLBr_01115 Mycobacterium leprae Br4923 lipoprotein YP_002503442.1 1291603 D 561304 CDS YP_002503443.1 221230027 7326581 1292178..1292741 1 NC_011896.1 lipoprotein 1292741 7326581 MLBr_01116 Mycobacterium leprae Br4923 lipoprotein YP_002503443.1 1292178 D 561304 CDS YP_002503444.1 221230028 7326582 complement(1292749..1293234) 1 NC_011896.1 hypothetical protein 1293234 7326582 MLBr_01117 Mycobacterium leprae Br4923 hypothetical protein YP_002503444.1 1292749 R 561304 CDS YP_002503445.1 221230029 7326584 1294803..1295954 1 NC_011896.1 hypothetical protein 1295954 7326584 MLBr_01119 Mycobacterium leprae Br4923 hypothetical protein YP_002503445.1 1294803 D 561304 CDS YP_002503446.1 221230030 7326585 1295951..1298572 1 NC_011896.1 hypothetical protein 1298572 7326585 MLBr_01120 Mycobacterium leprae Br4923 hypothetical protein YP_002503446.1 1295951 D 561304 CDS YP_002503447.1 221230031 7326586 complement(1299760..1301433) 1 NC_011896.1 extracellular solute-binding dependent transport lipoprotein 1301433 7326586 MLBr_01121 Mycobacterium leprae Br4923 extracellular solute-binding dependent transport lipoprotein YP_002503447.1 1299760 R 561304 CDS YP_002503448.1 221230032 7326587 complement(1301430..1303259) 1 NC_011896.1 ABC transporter ATP-binding protein 1303259 7326587 MLBr_01122 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503448.1 1301430 R 561304 CDS YP_002503449.1 221230033 7326588 complement(1303256..1304155) 1 NC_011896.1 binding-protein dependent transport protein 1304155 7326588 MLBr_01123 Mycobacterium leprae Br4923 binding-protein dependent transport protein YP_002503449.1 1303256 R 561304 CDS YP_002503450.1 221230034 7326589 complement(1304152..1305129) 1 NC_011896.1 binding-protein dependent transport protein 1305129 7326589 MLBr_01124 Mycobacterium leprae Br4923 binding-protein dependent transport protein YP_002503450.1 1304152 R 561304 CDS YP_002503451.1 221230035 7327228 1316611..1318263 1 NC_011896.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1318263 argS 7327228 argS Mycobacterium leprae Br4923 arginyl-tRNA synthetase YP_002503451.1 1316611 D 561304 CDS YP_002503452.1 221230036 7327225 1318260..1319678 1 NC_011896.1 diaminopimelate decarboxylase 1319678 lysA 7327225 lysA Mycobacterium leprae Br4923 diaminopimelate decarboxylase YP_002503452.1 1318260 D 561304 CDS YP_002503453.1 221230037 7325429 1319682..1321007 1 NC_011896.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1321007 hom 7325429 hom Mycobacterium leprae Br4923 homoserine dehydrogenase YP_002503453.1 1319682 D 561304 CDS YP_002503454.1 221230038 7324691 1321004..1322086 1 NC_011896.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1322086 thrC 7324691 thrC Mycobacterium leprae Br4923 threonine synthase YP_002503454.1 1321004 D 561304 CDS YP_002503455.1 221230039 7326020 1322154..1323101 1 NC_011896.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1323101 thrB 7326020 thrB Mycobacterium leprae Br4923 homoserine kinase YP_002503455.1 1322154 D 561304 CDS YP_002503456.1 221230040 7326019 1323371..1325203 1 NC_011896.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1325203 rho 7326019 rho Mycobacterium leprae Br4923 transcription termination factor Rho YP_002503456.1 1323371 D 561304 CDS YP_002503457.1 221230041 7326619 1325514..1325768 1 NC_011896.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1325768 rpmE 7326619 rpmE Mycobacterium leprae Br4923 50S ribosomal protein L31 YP_002503457.1 1325514 D 561304 CDS YP_002503458.1 221230042 7326668 1325859..1326944 1 NC_011896.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1326944 prfA 7326668 prfA Mycobacterium leprae Br4923 peptide chain release factor 1 YP_002503458.1 1325859 D 561304 CDS YP_002503459.1 221230043 7325005 1326941..1327807 1 NC_011896.1 protoporphyrinogen oxidase 1327807 7325005 MLBr_01135 Mycobacterium leprae Br4923 protoporphyrinogen oxidase YP_002503459.1 1326941 D 561304 CDS YP_002503460.1 221230044 7326593 1327847..1328509 1 NC_011896.1 hypothetical protein 1328509 7326593 MLBr_01136 Mycobacterium leprae Br4923 hypothetical protein YP_002503460.1 1327847 D 561304 CDS YP_002503461.1 221230045 7326594 1328540..1329739 1 NC_011896.1 glycosyltransferase 1329739 7326594 MLBr_01137 Mycobacterium leprae Br4923 glycosyltransferase YP_002503461.1 1328540 D 561304 CDS YP_002503462.1 221230046 7326595 1330002..1330463 1 NC_011896.1 integral membrane protein 1330463 7326595 MLBr_01138 Mycobacterium leprae Br4923 integral membrane protein YP_002503462.1 1330002 D 561304 CDS YP_002503463.1 221230047 7326596 1330460..1331215 1 NC_011896.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1331215 atpB 7326596 atpB Mycobacterium leprae Br4923 ATP synthase F0F1 subunit A YP_002503463.1 1330460 D 561304 CDS YP_002503464.1 221230048 7327246 1331311..1331556 1 NC_011896.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1331556 atpE 7327246 atpE Mycobacterium leprae Br4923 ATP synthase F0F1 subunit C YP_002503464.1 1331311 D 561304 CDS YP_002503465.1 221230049 7327249 1331578..1332090 1 NC_011896.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1332090 atpF 7327249 atpF Mycobacterium leprae Br4923 ATP synthase F0F1 subunit B YP_002503465.1 1331578 D 561304 CDS YP_002503466.1 221230050 7327250 1332096..1333436 1 NC_011896.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1333436 atpH 7327250 atpH Mycobacterium leprae Br4923 ATP synthase F0F1 subunit delta YP_002503466.1 1332096 D 561304 CDS YP_002503467.1 221230051 7327252 1333498..1335174 1 NC_011896.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1335174 atpA 7327252 atpA Mycobacterium leprae Br4923 ATP synthase F0F1 subunit alpha YP_002503467.1 1333498 D 561304 CDS YP_002503468.1 221230052 7327245 1335192..1336088 1 NC_011896.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1336088 atpG 7327245 atpG Mycobacterium leprae Br4923 ATP synthase F0F1 subunit gamma YP_002503468.1 1335192 D 561304 CDS YP_002503469.1 221230053 7327251 1336115..1337572 1 NC_011896.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1337572 atpD 7327251 atpD Mycobacterium leprae Br4923 ATP synthase F0F1 subunit beta YP_002503469.1 1336115 D 561304 CDS YP_002503470.1 221230054 7327248 1337605..1337970 1 NC_011896.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1337970 atpC 7327248 atpC Mycobacterium leprae Br4923 ATP synthase F0F1 subunit epsilon YP_002503470.1 1337605 D 561304 CDS YP_002503471.1 221230055 7327247 1337977..1338420 1 NC_011896.1 hypothetical protein 1338420 7327247 MLBr_01147 Mycobacterium leprae Br4923 hypothetical protein YP_002503471.1 1337977 D 561304 CDS YP_002503472.1 221230056 7326597 complement(1338559..1338714) 1 NC_011896.1 hypothetical protein 1338714 7326597 MLBr_01148 Mycobacterium leprae Br4923 hypothetical protein YP_002503472.1 1338559 R 561304 CDS YP_002503473.1 221230057 7326598 complement(1338927..1339502) 1 NC_011896.1 hypothetical protein 1339502 7326598 MLBr_01149 Mycobacterium leprae Br4923 hypothetical protein YP_002503473.1 1338927 R 561304 CDS YP_002503474.1 221230058 7326599 1339620..1340876 1 NC_011896.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1340876 murA 7326599 murA Mycobacterium leprae Br4923 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002503474.1 1339620 D 561304 CDS YP_002503475.1 221230059 7324934 complement(1346400..1346897) 1 NC_011896.1 methylated-DNA--protein-cysteine methyltransferase 1346897 ogt 7324934 ogt Mycobacterium leprae Br4923 methylated-DNA--protein-cysteine methyltransferase YP_002503475.1 1346400 R 561304 CDS YP_002503476.1 221230060 7326601 1351399..1352061 1 NC_011896.1 hypothetical protein 1352061 7326601 MLBr_01155 Mycobacterium leprae Br4923 hypothetical protein YP_002503476.1 1351399 D 561304 CDS YP_002503477.1 221230061 7327034 complement(1352393..1352860) 1 NC_011896.1 hypothetical protein 1352860 7327034 MLBr_01157 Mycobacterium leprae Br4923 hypothetical protein YP_002503477.1 1352393 R 561304 CDS YP_002503478.1 221230062 7327035 1352952..1354133 1 NC_011896.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1354133 fadA4 7327035 fadA4 Mycobacterium leprae Br4923 acetyl-CoA acetyltransferase YP_002503478.1 1352952 D 561304 CDS YP_002503479.1 221230063 7325239 1354320..1355225 1 NC_011896.1 hypothetical protein 1355225 7325239 MLBr_01159 Mycobacterium leprae Br4923 hypothetical protein YP_002503479.1 1354320 D 561304 CDS YP_002503480.1 221230064 7327041 1364652..1364978 1 NC_011896.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1364978 clpS 7327041 clpS Mycobacterium leprae Br4923 ATP-dependent Clp protease adaptor protein ClpS YP_002503480.1 1364652 D 561304 CDS YP_002503481.1 221230065 7327042 1365004..1365591 1 NC_011896.1 hypothetical protein 1365591 7327042 MLBr_01166 Mycobacterium leprae Br4923 hypothetical protein YP_002503481.1 1365004 D 561304 CDS YP_002503482.1 221230066 7327043 1365591..1366679 1 NC_011896.1 hydrolase 1366679 7327043 MLBr_01167 Mycobacterium leprae Br4923 hydrolase YP_002503482.1 1365591 D 561304 CDS YP_002503483.1 221230067 7326151 1368532..1369248 1 NC_011896.1 hypothetical protein 1369248 7326151 MLBr_01171 Mycobacterium leprae Br4923 hypothetical protein YP_002503483.1 1368532 D 561304 CDS YP_002503484.1 221230068 7327047 1369245..1370063 1 NC_011896.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1370063 murI 7327047 murI Mycobacterium leprae Br4923 glutamate racemase YP_002503484.1 1369245 D 561304 CDS YP_002503485.1 221230069 7324941 1370136..1370918 1 NC_011896.1 hypothetical protein 1370918 7324941 MLBr_01173 Mycobacterium leprae Br4923 hypothetical protein YP_002503485.1 1370136 D 561304 CDS YP_002503486.1 221230070 7327048 1371008..1371787 1 NC_011896.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1371787 rph 7327048 rph Mycobacterium leprae Br4923 ribonuclease PH YP_002503486.1 1371008 D 561304 CDS YP_002503487.1 221230071 7326640 1371822..1372484 1 NC_011896.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1372484 7326640 MLBr_01175 Mycobacterium leprae Br4923 deoxyribonucleotide triphosphate pyrophosphatase YP_002503487.1 1371822 D 561304 CDS YP_002503488.1 221230072 7327049 complement(1372525..1372884) 1 NC_011896.1 hypothetical protein 1372884 7327049 MLBr_01176 Mycobacterium leprae Br4923 hypothetical protein YP_002503488.1 1372525 R 561304 CDS YP_002503489.1 221230073 7327050 complement(1372881..1373261) 1 NC_011896.1 lipoprotein 1373261 7327050 MLBr_01177 Mycobacterium leprae Br4923 lipoprotein YP_002503489.1 1372881 R 561304 CDS YP_002503490.1 221230074 7327053 complement(1380340..1380627) 1 NC_011896.1 hypothetical protein 1380627 7327053 MLBr_01180 Mycobacterium leprae Br4923 hypothetical protein YP_002503490.1 1380340 R 561304 CDS YP_002503491.1 221230075 7327054 complement(1380679..1380981) 1 NC_011896.1 hypothetical protein 1380981 7327054 MLBr_01181 Mycobacterium leprae Br4923 hypothetical protein YP_002503491.1 1380679 R 561304 CDS YP_002503492.1 221230076 7327055 complement(1381044..1382297) 1 NC_011896.1 PPE family protein 1382297 7327055 MLBr_01182 Mycobacterium leprae Br4923 PPE family protein YP_002503492.1 1381044 R 561304 CDS YP_002503493.1 221230077 7327056 complement(1382354..1382653) 1 NC_011896.1 hypothetical protein 1382653 7327056 MLBr_01183 Mycobacterium leprae Br4923 hypothetical protein YP_002503493.1 1382354 R 561304 CDS YP_002503494.1 221230078 7327059 complement(1386804..1387106) 1 NC_011896.1 hypothetical protein 1387106 7327059 MLBr_01186 Mycobacterium leprae Br4923 hypothetical protein YP_002503494.1 1386804 R 561304 CDS YP_002503495.1 221230079 7327061 complement(1390623..1390883) 1 NC_011896.1 hypothetical protein 1390883 7327061 MLBr_01188 Mycobacterium leprae Br4923 hypothetical protein YP_002503495.1 1390623 R 561304 CDS YP_002503496.1 221230080 7327062 complement(1392521..1392904) 1 NC_011896.1 hypothetical protein 1392904 7327062 MLBr_01189 Mycobacterium leprae Br4923 hypothetical protein YP_002503496.1 1392521 R 561304 CDS YP_002503497.1 221230081 7327063 1395319..1396038 1 NC_011896.1 hypothetical protein 1396038 7327063 MLBr_01190 Mycobacterium leprae Br4923 hypothetical protein YP_002503497.1 1395319 D 561304 CDS YP_002503498.1 221230082 7327064 1396650..1405880 1 NC_011896.1 fatty acid synthase 1405880 fas 7327064 fas Mycobacterium leprae Br4923 fatty acid synthase YP_002503498.1 1396650 D 561304 CDS YP_002503499.1 221230083 7325286 1405909..1406301 1 NC_011896.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1406301 acpS 7325286 acpS Mycobacterium leprae Br4923 4'-phosphopantetheinyl transferase YP_002503499.1 1405909 D 561304 CDS YP_002503500.1 221230084 7327186 1406391..1407719 1 NC_011896.1 hypothetical protein 1407719 7327186 MLBr_01193 Mycobacterium leprae Br4923 hypothetical protein YP_002503500.1 1406391 D 561304 CDS YP_002503501.1 221230085 7327066 1410813..1413992 1 NC_011896.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1413992 ileS 7327066 ileS Mycobacterium leprae Br4923 isoleucyl-tRNA synthetase YP_002503501.1 1410813 D 561304 CDS YP_002503502.1 221230086 7326173 complement(1416049..1416981) 1 NC_011896.1 L-asparaginase/L-glutaminase 1416981 ansA 7326173 ansA Mycobacterium leprae Br4923 L-asparaginase/L-glutaminase YP_002503502.1 1416049 R 561304 CDS YP_002503503.1 221230087 7327210 1417056..1417661 1 NC_011896.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1417661 lspA 7327210 lspA Mycobacterium leprae Br4923 lipoprotein signal peptidase YP_002503503.1 1417056 D 561304 CDS YP_002503504.1 221230088 7325426 1417780..1418706 1 NC_011896.1 pseudouridine synthase 1418706 7325426 MLBr_01200 Mycobacterium leprae Br4923 pseudouridine synthase YP_002503504.1 1417780 D 561304 CDS YP_002503505.1 221230089 7327073 1423041..1426574 1 NC_011896.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1426574 dnaE 7327073 dnaE Mycobacterium leprae Br4923 DNA polymerase III subunit alpha YP_002503505.1 1423041 D 561304 CDS YP_002503506.1 221230090 7327074 1428278..1429561 1 NC_011896.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1429561 ilvA 7327074 ilvA Mycobacterium leprae Br4923 threonine dehydratase YP_002503506.1 1428278 D 561304 CDS YP_002503507.1 221230091 7324708 1431121..1431306 1 NC_011896.1 hypothetical protein 1431306 7324708 MLBr_01210 Mycobacterium leprae Br4923 hypothetical protein YP_002503507.1 1431121 D 561304 CDS YP_002503508.1 221230092 7325345 complement(1434706..1436907) 1 NC_011896.1 hypothetical protein 1436907 7325345 MLBr_01213 Mycobacterium leprae Br4923 hypothetical protein YP_002503508.1 1434706 R 561304 CDS YP_002503509.1 221230093 7327076 complement(1437037..1437675) 1 NC_011896.1 p60-family protein 1437675 7327076 MLBr_01214 Mycobacterium leprae Br4923 p60-family protein YP_002503509.1 1437037 R 561304 CDS YP_002503510.1 221230094 7327078 1438624..1439934 1 NC_011896.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1439934 bioA 7327078 bioA Mycobacterium leprae Br4923 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002503510.1 1438624 D 561304 CDS YP_002503511.1 221230095 7327261 1439941..1441098 1 NC_011896.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1441098 bioF 7327261 bioF Mycobacterium leprae Br4923 8-amino-7-oxononanoate synthase YP_002503511.1 1439941 D 561304 CDS YP_002503512.1 221230096 7327264 1441095..1441775 1 NC_011896.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1441775 bioD 7327264 bioD Mycobacterium leprae Br4923 dithiobiotin synthetase YP_002503512.1 1441095 D 561304 CDS YP_002503513.1 221230097 7327079 1442529..1443566 1 NC_011896.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1443566 bioB 7327079 bioB Mycobacterium leprae Br4923 biotin synthase YP_002503513.1 1442529 D 561304 CDS YP_002503514.1 221230098 7327262 1443592..1443834 1 NC_011896.1 hypothetical protein 1443834 7327262 MLBr_01221 Mycobacterium leprae Br4923 hypothetical protein YP_002503514.1 1443592 D 561304 CDS YP_002503515.1 221230099 7327080 1443831..1444427 1 NC_011896.1 hypothetical protein 1444427 7327080 MLBr_01222 Mycobacterium leprae Br4923 hypothetical protein YP_002503515.1 1443831 D 561304 CDS YP_002503516.1 221230100 7327082 complement(1445974..1446693) 1 NC_011896.1 hypothetical protein 1446693 7327082 MLBr_01224 Mycobacterium leprae Br4923 hypothetical protein YP_002503516.1 1445974 R 561304 CDS YP_002503517.1 221230101 7327083 1446740..1447798 1 NC_011896.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1447798 nadA 7327083 nadA Mycobacterium leprae Br4923 quinolinate synthetase YP_002503517.1 1446740 D 561304 CDS YP_002503518.1 221230102 7324947 1447795..1449378 1 NC_011896.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1449378 nadB 7324947 nadB Mycobacterium leprae Br4923 L-aspartate oxidase YP_002503518.1 1447795 D 561304 CDS YP_002503519.1 221230103 7324948 1449375..1450235 1 NC_011896.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1450235 nadC 7324948 nadC Mycobacterium leprae Br4923 nicotinate-nucleotide pyrophosphorylase YP_002503519.1 1449375 D 561304 CDS YP_002503520.1 221230104 7327084 1454324..1460680 1 NC_011896.1 mycocerosic acid synthase (polyketide synthase) 1460680 pks3 7327084 pks3 Mycobacterium leprae Br4923 mycocerosic acid synthase (polyketide synthase) YP_002503520.1 1454324 D 561304 CDS YP_002503521.1 221230105 7326439 1460761..1462176 1 NC_011896.1 PKS-associated protein 1462176 papA3 7326439 papA3 Mycobacterium leprae Br4923 PKS-associated protein YP_002503521.1 1460761 D 561304 CDS YP_002503522.1 221230106 7327351 1462258..1465209 1 NC_011896.1 hypothetical protein 1465209 mmpL10 7327351 mmpL10 Mycobacterium leprae Br4923 hypothetical protein YP_002503522.1 1462258 D 561304 CDS YP_002503523.1 221230107 7324905 complement(1465637..1466713) 1 NC_011896.1 hypothetical protein 1466713 7324905 MLBr_01232 Mycobacterium leprae Br4923 hypothetical protein YP_002503523.1 1465637 R 561304 CDS YP_002503524.1 221230108 7327085 complement(1466878..1467570) 1 NC_011896.1 hypothetical protein 1467570 7327085 MLBr_01233 Mycobacterium leprae Br4923 hypothetical protein YP_002503524.1 1466878 R 561304 CDS YP_002503525.1 221230109 7327086 complement(1467600..1469339) 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1469339 7327086 MLBr_01234 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002503525.1 1467600 R 561304 CDS YP_002503526.1 221230110 7327091 1476575..1477459 1 NC_011896.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1477459 7327091 MLBr_01241 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002503526.1 1476575 D 561304 CDS YP_002503527.1 221230111 7327229 1482157..1482618 1 NC_011896.1 hypothetical protein 1482618 7327229 MLBr_01243 Mycobacterium leprae Br4923 hypothetical protein YP_002503527.1 1482157 D 561304 CDS YP_002503528.1 221230112 7327094 1482841..1484316 1 NC_011896.1 hypothetical protein 1484316 7327094 MLBr_01244 Mycobacterium leprae Br4923 hypothetical protein YP_002503528.1 1482841 D 561304 CDS YP_002503529.1 221230113 7327095 1484313..1486052 1 NC_011896.1 transferase 1486052 7327095 MLBr_01245 Mycobacterium leprae Br4923 transferase YP_002503529.1 1484313 D 561304 CDS YP_002503530.1 221230114 7327096 1486049..1488376 1 NC_011896.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1488376 plsB 7327096 plsB Mycobacterium leprae Br4923 glycerol-3-phosphate acyltransferase YP_002503530.1 1486049 D 561304 CDS YP_002503531.1 221230115 7327097 1489194..1490864 1 NC_011896.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1490864 7327097 MLBr_01248 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503531.1 1489194 D 561304 CDS YP_002503532.1 221230116 7327098 1490923..1495791 1 NC_011896.1 hypothetical protein 1495791 7327098 MLBr_01249 Mycobacterium leprae Br4923 hypothetical protein YP_002503532.1 1490923 D 561304 CDS YP_002503533.1 221230117 7327102 complement(1498175..1498561) 1 NC_011896.1 hemoglobin-like, oxygen carrier 1498561 glbO 7327102 glbO Mycobacterium leprae Br4923 hemoglobin-like, oxygen carrier YP_002503533.1 1498175 R 561304 CDS YP_002503534.1 221230118 7325341 1498730..1499377 1 NC_011896.1 hypothetical protein 1499377 7325341 MLBr_01254 Mycobacterium leprae Br4923 hypothetical protein YP_002503534.1 1498730 D 561304 CDS YP_002503535.1 221230119 7327103 1499792..1500283 1 NC_011896.1 hypothetical protein 1500283 7327103 MLBr_01255 Mycobacterium leprae Br4923 hypothetical protein YP_002503535.1 1499792 D 561304 CDS YP_002503536.1 221230120 7327105 1502321..1503670 1 NC_011896.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1503670 hisD 7327105 hisD Mycobacterium leprae Br4923 histidinol dehydrogenase YP_002503536.1 1502321 D 561304 CDS YP_002503537.1 221230121 7324682 1503667..1504800 1 NC_011896.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1504800 hisC 7324682 hisC Mycobacterium leprae Br4923 histidinol-phosphate aminotransferase YP_002503537.1 1503667 D 561304 CDS YP_002503538.1 221230122 7324680 1504797..1505429 1 NC_011896.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1505429 hisB 7324680 hisB Mycobacterium leprae Br4923 imidazoleglycerol-phosphate dehydratase YP_002503538.1 1504797 D 561304 CDS YP_002503539.1 221230123 7324679 1505426..1506046 1 NC_011896.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1506046 hisH 7324679 hisH Mycobacterium leprae Br4923 imidazole glycerol phosphate synthase subunit HisH YP_002503539.1 1505426 D 561304 CDS YP_002503540.1 221230124 7324686 1506056..1506793 1 NC_011896.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1506793 hisA 7324686 hisA Mycobacterium leprae Br4923 phosphoribosyl isomerase A YP_002503540.1 1506056 D 561304 CDS YP_002503541.1 221230125 7324716 1507601..1508386 1 NC_011896.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1508386 hisF 7324716 hisF Mycobacterium leprae Br4923 imidazole glycerol phosphate synthase subunit HisF YP_002503541.1 1507601 D 561304 CDS YP_002503542.1 221230126 7324684 1508383..1508730 1 NC_011896.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1508730 hisI 7324684 hisI Mycobacterium leprae Br4923 phosphoribosyl-AMP cyclohydrolase YP_002503542.1 1508383 D 561304 CDS YP_002503543.1 221230127 7327107 1510464..1511558 1 NC_011896.1 antiporter 1511558 7327107 MLBr_01267 Mycobacterium leprae Br4923 antiporter YP_002503543.1 1510464 D 561304 CDS YP_002503544.1 221230128 7327109 1512163..1513752 1 NC_011896.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1513752 trpE 7327109 trpE Mycobacterium leprae Br4923 anthranilate synthase component I YP_002503544.1 1512163 D 561304 CDS YP_002503545.1 221230129 7327284 1513749..1514546 1 NC_011896.1 hypothetical protein 1514546 7327284 MLBr_01270 Mycobacterium leprae Br4923 hypothetical protein YP_002503545.1 1513749 D 561304 CDS YP_002503546.1 221230130 7327110 1514524..1515342 1 NC_011896.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1515342 trpC 7327110 trpC Mycobacterium leprae Br4923 indole-3-glycerol phosphate synthase YP_002503546.1 1514524 D 561304 CDS YP_002503547.1 221230131 7327282 1515406..1516659 1 NC_011896.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1516659 trpB 7327282 trpB Mycobacterium leprae Br4923 tryptophan synthase subunit beta YP_002503547.1 1515406 D 561304 CDS YP_002503548.1 221230132 7327281 1516656..1517468 1 NC_011896.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1517468 trpA 7327281 trpA Mycobacterium leprae Br4923 tryptophan synthase subunit alpha YP_002503548.1 1516656 D 561304 CDS YP_002503549.1 221230133 7327280 1517465..1518457 1 NC_011896.1 prolipoprotein diacylglyceryl transferase 1518457 7327280 MLBr_01274 Mycobacterium leprae Br4923 prolipoprotein diacylglyceryl transferase YP_002503549.1 1517465 D 561304 CDS YP_002503550.1 221230134 7327111 1518454..1518690 1 NC_011896.1 hypothetical protein 1518690 7327111 MLBr_01275 Mycobacterium leprae Br4923 hypothetical protein YP_002503550.1 1518454 D 561304 CDS YP_002503551.1 221230135 7327112 1519242..1519682 1 NC_011896.1 hypothetical protein 1519682 7327112 MLBr_01276 Mycobacterium leprae Br4923 hypothetical protein YP_002503551.1 1519242 D 561304 CDS YP_002503552.1 221230136 7327113 1519765..1521183 1 NC_011896.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1521183 pykA 7327113 pykA Mycobacterium leprae Br4923 pyruvate kinase YP_002503552.1 1519765 D 561304 CDS YP_002503553.1 221230137 7325044 1521290..1522183 1 NC_011896.1 acyl CoA thioesterase II 1522183 tesB 7325044 tesB Mycobacterium leprae Br4923 acyl CoA thioesterase II YP_002503553.1 1521290 D 561304 CDS YP_002503554.1 221230138 7325380 1531889..1532506 1 NC_011896.1 two-component response regulatory protein 1532506 7325380 MLBr_01286 Mycobacterium leprae Br4923 two-component response regulatory protein YP_002503554.1 1531889 D 561304 CDS YP_002503555.1 221230139 7325379 1536172..1537575 1 NC_011896.1 hypothetical protein 1537575 7325379 MLBr_01288 Mycobacterium leprae Br4923 hypothetical protein YP_002503555.1 1536172 D 561304 CDS YP_002503556.1 221230140 7326444 1537607..1538137 1 NC_011896.1 hypothetical protein 1538137 7326444 MLBr_01289 Mycobacterium leprae Br4923 hypothetical protein YP_002503556.1 1537607 D 561304 CDS YP_002503557.1 221230141 7326447 complement(1540635..1540877) 1 NC_011896.1 hypothetical protein 1540877 7326447 MLBr_01292 Mycobacterium leprae Br4923 hypothetical protein YP_002503557.1 1540635 R 561304 CDS YP_002503558.1 221230142 7326448 complement(1543287..1544360) 1 NC_011896.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1544360 pyrD 7326448 pyrD Mycobacterium leprae Br4923 dihydroorotate dehydrogenase 2 YP_002503558.1 1543287 R 561304 CDS YP_002503559.1 221230143 7325047 complement(1544378..1544632) 1 NC_011896.1 hypothetical protein 1544632 7325047 MLBr_01294 Mycobacterium leprae Br4923 hypothetical protein YP_002503559.1 1544378 R 561304 CDS YP_002503560.1 221230144 7326450 1545763..1546098 1 NC_011896.1 hypothetical protein 1546098 7326450 MLBr_01296 Mycobacterium leprae Br4923 hypothetical protein YP_002503560.1 1545763 D 561304 CDS YP_002503561.1 221230145 7326451 1546139..1546987 1 NC_011896.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 1546987 7326451 MLBr_01297 Mycobacterium leprae Br4923 UDP pyrophosphate phosphatase YP_002503561.1 1546139 D 561304 CDS YP_002503562.1 221230146 7326452 1546984..1547736 1 NC_011896.1 hypothetical protein 1547736 7326452 MLBr_01298 Mycobacterium leprae Br4923 hypothetical protein YP_002503562.1 1546984 D 561304 CDS YP_002503563.1 221230147 7326453 1547814..1548404 1 NC_011896.1 hypothetical protein 1548404 7326453 MLBr_01299 Mycobacterium leprae Br4923 hypothetical protein YP_002503563.1 1547814 D 561304 CDS YP_002503564.1 221230148 7326454 1548415..1549203 1 NC_011896.1 hypothetical protein 1549203 7326454 MLBr_01300 Mycobacterium leprae Br4923 hypothetical protein YP_002503564.1 1548415 D 561304 CDS YP_002503565.1 221230149 7326455 1549242..1550057 1 NC_011896.1 inositol monophosphatase 1550057 7326455 MLBr_01301 Mycobacterium leprae Br4923 inositol monophosphatase YP_002503565.1 1549242 D 561304 CDS YP_002503566.1 221230150 7326456 1550253..1551407 1 NC_011896.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1551407 cysS2 7326456 cysS2 Mycobacterium leprae Br4923 cysteinyl-tRNA synthetase YP_002503566.1 1550253 D 561304 CDS YP_002503567.1 221230151 7326457 complement(1552542..1554038) 1 NC_011896.1 L-asparagine permease 1554038 ansP1 7326457 ansP1 Mycobacterium leprae Br4923 L-asparagine permease YP_002503567.1 1552542 R 561304 CDS YP_002503568.1 221230152 7327212 complement(1554188..1555705) 1 NC_011896.1 L-asparagine permease 1555705 ansP2 7327212 ansP2 Mycobacterium leprae Br4923 L-asparagine permease YP_002503568.1 1554188 R 561304 CDS YP_002503569.1 221230153 7327213 complement(1555842..1556666) 1 NC_011896.1 hypothetical protein 1556666 7327213 MLBr_01306 Mycobacterium leprae Br4923 hypothetical protein YP_002503569.1 1555842 R 561304 CDS YP_002503570.1 221230154 7326458 1556874..1560494 1 NC_011896.1 5-methyltetrahydrofolate--homocysteine methyltransferase 1560494 metH 7326458 metH Mycobacterium leprae Br4923 5-methyltetrahydrofolate--homocysteine methyltransferase YP_002503570.1 1556874 D 561304 CDS YP_002503571.1 221230155 7324991 1561989..1562270 1 NC_011896.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 1562270 hisE 7324991 hisE Mycobacterium leprae Br4923 phosphoribosyl-ATP pyrophosphatase YP_002503571.1 1561989 D 561304 CDS YP_002503572.1 221230156 7324683 1562267..1563136 1 NC_011896.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1563136 hisG 7324683 hisG Mycobacterium leprae Br4923 ATP phosphoribosyltransferase YP_002503572.1 1562267 D 561304 CDS YP_002503573.1 221230157 7326459 complement(1565176..1566060) 1 NC_011896.1 hypothetical protein 1566060 7326459 MLBr_01312 Mycobacterium leprae Br4923 hypothetical protein YP_002503573.1 1565176 R 561304 CDS YP_002503574.1 221230158 7326460 1566134..1566979 1 NC_011896.1 hypothetical protein 1566979 7326460 MLBr_01313 Mycobacterium leprae Br4923 hypothetical protein YP_002503574.1 1566134 D 561304 CDS YP_002503575.1 221230159 7326461 complement(1567093..1567386) 1 NC_011896.1 hypothetical protein 1567386 7326461 MLBr_01314 Mycobacterium leprae Br4923 hypothetical protein YP_002503575.1 1567093 R 561304 CDS YP_002503576.1 221230160 7326462 complement(1567395..1567979) 1 NC_011896.1 lipoprotein 1567979 7326462 MLBr_01315 Mycobacterium leprae Br4923 lipoprotein YP_002503576.1 1567395 R 561304 CDS YP_002503577.1 221230161 7326463 1568267..1570096 1 NC_011896.1 AAA ATPase 1570096 7326463 MLBr_01316 Mycobacterium leprae Br4923 AAA ATPase YP_002503577.1 1568267 D 561304 CDS YP_002503578.1 221230162 7326467 1573940..1575484 1 NC_011896.1 hypothetical protein 1575484 7326467 MLBr_01320 Mycobacterium leprae Br4923 hypothetical protein YP_002503578.1 1573940 D 561304 CDS YP_002503579.1 221230163 7326468 1575516..1575707 1 NC_011896.1 hypothetical protein 1575707 7326468 MLBr_01321 Mycobacterium leprae Br4923 hypothetical protein YP_002503579.1 1575516 D 561304 CDS YP_002503580.1 221230164 7326469 1575704..1576579 1 NC_011896.1 proteasome beta-type subunit 2 1576579 prcB 7326469 prcB Mycobacterium leprae Br4923 proteasome beta-type subunit 2 YP_002503580.1 1575704 D 561304 CDS YP_002503581.1 221230165 7325004 1576576..1577373 1 NC_011896.1 proteasome alpha-type subunit 1 1577373 prcA 7325004 prcA Mycobacterium leprae Br4923 proteasome alpha-type subunit 1 YP_002503581.1 1576576 D 561304 CDS YP_002503582.1 221230166 7326473 1579824..1581182 1 NC_011896.1 DNA-binding protein 1581182 7326473 MLBr_01328 Mycobacterium leprae Br4923 DNA-binding protein YP_002503582.1 1579824 D 561304 CDS YP_002503583.1 221230167 7326474 1581189..1582184 1 NC_011896.1 hypothetical protein 1582184 7326474 MLBr_01329 Mycobacterium leprae Br4923 hypothetical protein YP_002503583.1 1581189 D 561304 CDS YP_002503584.1 221230168 7326475 1582181..1583155 1 NC_011896.1 DNA-binding protein 1583155 7326475 MLBr_01330 Mycobacterium leprae Br4923 DNA-binding protein YP_002503584.1 1582181 D 561304 CDS YP_002503585.1 221230169 7326476 1583207..1583494 1 NC_011896.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 1583494 tatA 7326476 tatA Mycobacterium leprae Br4923 twin arginine translocase A YP_002503585.1 1583207 D 561304 CDS YP_002503586.1 221230170 7326477 1583633..1584493 1 NC_011896.1 membrane transport protein 1584493 7326477 MLBr_01332 Mycobacterium leprae Br4923 membrane transport protein YP_002503586.1 1583633 D 561304 CDS YP_002503587.1 221230171 7326478 1584518..1587280 1 NC_011896.1 helicase, Ski2 subfamily 1587280 helY 7326478 helY Mycobacterium leprae Br4923 helicase, Ski2 subfamily YP_002503587.1 1584518 D 561304 CDS YP_002503588.1 221230172 7324669 1587345..1588073 1 NC_011896.1 hypothetical protein 1588073 7324669 MLBr_01334 Mycobacterium leprae Br4923 hypothetical protein YP_002503588.1 1587345 D 561304 CDS YP_002503589.1 221230173 7326481 complement(1595382..1596704) 1 NC_011896.1 hypothetical protein 1596704 7326481 MLBr_01338 Mycobacterium leprae Br4923 hypothetical protein YP_002503589.1 1595382 R 561304 CDS YP_002503590.1 221230174 7326482 complement(1596724..1598301) 1 NC_011896.1 protease 1598301 7326482 MLBr_01339 Mycobacterium leprae Br4923 protease YP_002503590.1 1596724 R 561304 CDS YP_002503591.1 221230175 7326483 complement(1598315..1599121) 1 NC_011896.1 hypothetical protein 1599121 7326483 MLBr_01340 Mycobacterium leprae Br4923 hypothetical protein YP_002503591.1 1598315 R 561304 CDS YP_002503592.1 221230176 7327311 complement(1602915..1603175) 1 NC_011896.1 hypothetical protein 1603175 7327311 MLBr_01344 Mycobacterium leprae Br4923 hypothetical protein YP_002503592.1 1602915 R 561304 CDS YP_002503593.1 221230177 7326489 1606046..1609054 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1609054 7326489 MLBr_01346 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002503593.1 1606046 D 561304 CDS YP_002503594.1 221230178 7326490 1609047..1609280 1 NC_011896.1 hypothetical protein 1609280 7326490 MLBr_01347 Mycobacterium leprae Br4923 hypothetical protein YP_002503594.1 1609047 D 561304 CDS YP_002503595.1 221230179 7326494 1611453..1612097 1 NC_011896.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1612097 7326494 MLBr_01351 Mycobacterium leprae Br4923 3-methyladenine DNA glycosylase YP_002503595.1 1611453 D 561304 CDS YP_002503596.1 221230180 7326495 1612108..1613388 1 NC_011896.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1613388 tyrS 7326495 tyrS Mycobacterium leprae Br4923 tyrosyl-tRNA synthetase YP_002503596.1 1612108 D 561304 CDS YP_002503597.1 221230181 7326499 1617849..1618034 1 NC_011896.1 hypothetical protein 1618034 7326499 MLBr_01357 Mycobacterium leprae Br4923 hypothetical protein YP_002503597.1 1617849 D 561304 CDS YP_002503598.1 221230182 7326500 1618042..1618851 1 NC_011896.1 cytotoxin/hemolysin 1618851 tlyA 7326500 tlyA Mycobacterium leprae Br4923 cytotoxin/hemolysin YP_002503598.1 1618042 D 561304 CDS YP_002503599.1 221230183 7326027 1618848..1619783 1 NC_011896.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1619783 ppnK 7326027 ppnK Mycobacterium leprae Br4923 inorganic polyphosphate/ATP-NAD kinase YP_002503599.1 1618848 D 561304 CDS YP_002503600.1 221230184 7326501 1619807..1621570 1 NC_011896.1 recombination and DNA repair 1621570 recN 7326501 recN Mycobacterium leprae Br4923 recombination and DNA repair YP_002503600.1 1619807 D 561304 CDS YP_002503601.1 221230185 7326612 1621756..1622937 1 NC_011896.1 hypothetical protein 1622937 7326612 MLBr_01361 Mycobacterium leprae Br4923 hypothetical protein YP_002503601.1 1621756 D 561304 CDS YP_002503602.1 221230186 7326502 1622959..1623912 1 NC_011896.1 hypothetical protein 1623912 7326502 MLBr_01362 Mycobacterium leprae Br4923 hypothetical protein YP_002503602.1 1622959 D 561304 CDS YP_002503603.1 221230187 7326503 1624085..1625857 1 NC_011896.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1625857 pyrG 7326503 pyrG Mycobacterium leprae Br4923 CTP synthetase YP_002503603.1 1624085 D 561304 CDS YP_002503604.1 221230188 7326504 1626471..1627421 1 NC_011896.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1627421 xerD 7326504 xerD Mycobacterium leprae Br4923 site-specific tyrosine recombinase XerD YP_002503604.1 1626471 D 561304 CDS YP_002503605.1 221230189 7326506 1627962..1628825 1 NC_011896.1 regulatory protein 1628825 7326506 MLBr_01367 Mycobacterium leprae Br4923 regulatory protein YP_002503605.1 1627962 D 561304 CDS YP_002503606.1 221230190 7326507 1628822..1629628 1 NC_011896.1 hypothetical protein 1629628 7326507 MLBr_01368 Mycobacterium leprae Br4923 hypothetical protein YP_002503606.1 1628822 D 561304 CDS YP_002503607.1 221230191 7326508 1629676..1630371 1 NC_011896.1 hypothetical protein 1630371 7326508 MLBr_01369 Mycobacterium leprae Br4923 hypothetical protein YP_002503607.1 1629676 D 561304 CDS YP_002503608.1 221230192 7326509 1630368..1631141 1 NC_011896.1 pseudouridine synthase 1631141 7326509 MLBr_01370 Mycobacterium leprae Br4923 pseudouridine synthase YP_002503608.1 1630368 D 561304 CDS YP_002503609.1 221230193 7326510 1631138..1631809 1 NC_011896.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1631809 cmk 7326510 cmk Mycobacterium leprae Br4923 cytidylate kinase YP_002503609.1 1631138 D 561304 CDS YP_002503610.1 221230194 7326113 1631803..1633191 1 NC_011896.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1633191 engA 7326113 engA Mycobacterium leprae Br4923 GTP-binding protein EngA YP_002503610.1 1631803 D 561304 CDS YP_002503611.1 221230195 7326518 1645003..1645566 1 NC_011896.1 hypothetical protein 1645566 7326518 MLBr_01380 Mycobacterium leprae Br4923 hypothetical protein YP_002503611.1 1645003 D 561304 CDS YP_002503612.1 221230196 7326519 complement(1648153..1650888) 1 NC_011896.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1650888 polA 7326519 polA Mycobacterium leprae Br4923 DNA polymerase I YP_002503612.1 1648153 R 561304 CDS YP_002503613.1 221230197 7324980 1652661..1654106 1 NC_011896.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1654106 rpsA 7324980 rpsA Mycobacterium leprae Br4923 30S ribosomal protein S1 YP_002503613.1 1652661 D 561304 CDS YP_002503614.1 221230198 7326677 1654133..1655365 1 NC_011896.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1655365 coaE 7326677 coaE Mycobacterium leprae Br4923 dephospho-CoA kinase/protein folding accessory domain-containing protein YP_002503614.1 1654133 D 561304 CDS YP_002503615.1 221230199 7326520 1656158..1656496 1 NC_011896.1 hypothetical protein 1656496 7326520 MLBr_01384 Mycobacterium leprae Br4923 hypothetical protein YP_002503615.1 1656158 D 561304 CDS YP_002503616.1 221230200 7327405 1661598..1663694 1 NC_011896.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1663694 uvrB 7327405 uvrB Mycobacterium leprae Br4923 excinuclease ABC subunit B YP_002503616.1 1661598 D 561304 CDS YP_002503617.1 221230201 7326849 complement(1665107..1666690) 1 NC_011896.1 hypothetical protein 1666690 7326849 MLBr_01389 Mycobacterium leprae Br4923 hypothetical protein YP_002503617.1 1665107 R 561304 CDS YP_002503618.1 221230202 7326850 1666982..1667425 1 NC_011896.1 hypothetical protein 1667425 7326850 MLBr_01390 Mycobacterium leprae Br4923 hypothetical protein YP_002503618.1 1666982 D 561304 CDS YP_002503619.1 221230203 7326851 complement(1667434..1668132) 1 NC_011896.1 hypothetical protein 1668132 7326851 MLBr_01391 Mycobacterium leprae Br4923 hypothetical protein YP_002503619.1 1667434 R 561304 CDS YP_002503620.1 221230204 7326852 1668270..1671179 1 NC_011896.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1671179 uvrA 7326852 uvrA Mycobacterium leprae Br4923 excinuclease ABC subunit A YP_002503620.1 1668270 D 561304 CDS YP_002503621.1 221230205 7327305 complement(1671856..1674975) 1 NC_011896.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1674975 lysS 7327305 lysS Mycobacterium leprae Br4923 lysyl-tRNA synthetase YP_002503621.1 1671856 R 561304 CDS YP_002503622.1 221230206 7325433 1675740..1676297 1 NC_011896.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1676297 infC 7325433 infC Mycobacterium leprae Br4923 translation initiation factor IF-3 YP_002503622.1 1675740 D 561304 CDS YP_002503623.1 221230207 7324719 1676348..1676542 1 NC_011896.1 50S ribosomal protein L35 1676542 rpmI 7324719 rpmI Mycobacterium leprae Br4923 50S ribosomal protein L35 YP_002503623.1 1676348 D 561304 CDS YP_002503624.1 221230208 7326671 1676596..1676985 1 NC_011896.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1676985 rplT 7326671 rplT Mycobacterium leprae Br4923 50S ribosomal protein L20 YP_002503624.1 1676596 D 561304 CDS YP_002503625.1 221230209 7326658 1677040..1677819 1 NC_011896.1 rRNA methyltransferase 1677819 tsnR 7326658 tsnR Mycobacterium leprae Br4923 rRNA methyltransferase YP_002503625.1 1677040 D 561304 CDS YP_002503626.1 221230210 7326853 1679147..1680121 1 NC_011896.1 hypothetical protein 1680121 7326853 MLBr_01399 Mycobacterium leprae Br4923 hypothetical protein YP_002503626.1 1679147 D 561304 CDS YP_002503627.1 221230211 7326855 1680970..1682022 1 NC_011896.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1682022 pheS 7326855 pheS Mycobacterium leprae Br4923 phenylalanyl-tRNA synthetase subunit alpha YP_002503627.1 1680970 D 561304 CDS YP_002503628.1 221230212 7327389 1682019..1684529 1 NC_011896.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1684529 pheT 7327389 pheT Mycobacterium leprae Br4923 phenylalanyl-tRNA synthetase subunit beta YP_002503628.1 1682019 D 561304 CDS YP_002503629.1 221230213 7326857 1687605..1688648 1 NC_011896.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1688648 argC 7326857 argC Mycobacterium leprae Br4923 N-acetyl-gamma-glutamyl-phosphate reductase YP_002503629.1 1687605 D 561304 CDS YP_002503630.1 221230214 7327218 1688645..1689868 1 NC_011896.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1689868 argJ 7327218 argJ Mycobacterium leprae Br4923 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase YP_002503630.1 1688645 D 561304 CDS YP_002503631.1 221230215 7327223 1689865..1690770 1 NC_011896.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1690770 argB 7327223 argB Mycobacterium leprae Br4923 acetylglutamate kinase YP_002503631.1 1689865 D 561304 CDS YP_002503632.1 221230216 7327217 1690822..1692036 1 NC_011896.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1692036 argD 7327217 argD Mycobacterium leprae Br4923 acetylornithine aminotransferase YP_002503632.1 1690822 D 561304 CDS YP_002503633.1 221230217 7327219 1692068..1693030 1 NC_011896.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1693030 argF 7327219 argF Mycobacterium leprae Br4923 ornithine carbamoyltransferase YP_002503633.1 1692068 D 561304 CDS YP_002503634.1 221230218 7327220 1693033..1693536 1 NC_011896.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1693536 argR 7327220 argR Mycobacterium leprae Br4923 arginine repressor ArgR YP_002503634.1 1693033 D 561304 CDS YP_002503635.1 221230219 7327224 1693546..1694745 1 NC_011896.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1694745 argG 7327224 argG Mycobacterium leprae Br4923 argininosuccinate synthase YP_002503635.1 1693546 D 561304 CDS YP_002503636.1 221230220 7327221 1694817..1696229 1 NC_011896.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1696229 argH 7327221 argH Mycobacterium leprae Br4923 argininosuccinate lyase YP_002503636.1 1694817 D 561304 CDS YP_002503637.1 221230221 7324969 1699581..1700387 1 NC_011896.1 CDP-diacylglycerol pyrophosphatase 1700387 7324969 MLBr_01417 Mycobacterium leprae Br4923 CDP-diacylglycerol pyrophosphatase YP_002503637.1 1699581 D 561304 CDS YP_002503638.1 221230222 7326859 complement(1700629..1701177) 1 NC_011896.1 hypothetical protein 1701177 7326859 MLBr_01418 Mycobacterium leprae Br4923 hypothetical protein YP_002503638.1 1700629 R 561304 CDS YP_002503639.1 221230223 7326860 complement(1704287..1705978) 1 NC_011896.1 regulatory protein 1705978 7326860 MLBr_01419 Mycobacterium leprae Br4923 regulatory protein YP_002503639.1 1704287 R 561304 CDS YP_002503640.1 221230224 7326861 1706324..1706677 1 NC_011896.1 hypothetical protein 1706677 7326861 MLBr_01420 Mycobacterium leprae Br4923 hypothetical protein YP_002503640.1 1706324 D 561304 CDS YP_002503641.1 221230225 7326864 complement(1710440..1711429) 1 NC_011896.1 hypothetical protein 1711429 7326864 MLBr_01423 Mycobacterium leprae Br4923 hypothetical protein YP_002503641.1 1710440 R 561304 CDS YP_002503642.1 221230226 7326865 complement(1711499..1712569) 1 NC_011896.1 binding-protein-dependent transport protein 1712569 7326865 MLBr_01424 Mycobacterium leprae Br4923 binding-protein-dependent transport protein YP_002503642.1 1711499 R 561304 CDS YP_002503643.1 221230227 7326866 complement(1712572..1713423) 1 NC_011896.1 ABC transporter inner membrane protein 1713423 7326866 MLBr_01425 Mycobacterium leprae Br4923 ABC transporter inner membrane protein YP_002503643.1 1712572 R 561304 CDS YP_002503644.1 221230228 7326867 complement(1713410..1714369) 1 NC_011896.1 ABC transporter inner membrane protein 1714369 7326867 MLBr_01426 Mycobacterium leprae Br4923 ABC transporter inner membrane protein YP_002503644.1 1713410 R 561304 CDS YP_002503645.1 221230229 7326868 complement(1714366..1715703) 1 NC_011896.1 ABC-transport lipoprotein 1715703 7326868 MLBr_01427 Mycobacterium leprae Br4923 ABC-transport lipoprotein YP_002503645.1 1714366 R 561304 CDS YP_002503646.1 221230230 7326870 1716857..1717183 1 NC_011896.1 hypothetical protein 1717183 7326870 MLBr_01430 Mycobacterium leprae Br4923 hypothetical protein YP_002503646.1 1716857 D 561304 CDS YP_002503647.1 221230231 7326875 1733280..1733615 1 NC_011896.1 hypothetical protein 1733615 7326875 MLBr_01439 Mycobacterium leprae Br4923 hypothetical protein YP_002503647.1 1733280 D 561304 CDS YP_002503648.1 221230232 7326876 complement(1733572..1734405) 1 NC_011896.1 glycosyl transferase family protein 1734405 7326876 MLBr_01440 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002503648.1 1733572 R 561304 CDS YP_002503649.1 221230233 7326877 complement(1734402..1736336) 1 NC_011896.1 apolipoprotein N-acyltransferase 1736336 7326877 MLBr_01441 Mycobacterium leprae Br4923 apolipoprotein N-acyltransferase YP_002503649.1 1734402 R 561304 CDS YP_002503650.1 221230234 7326880 1738528..1739226 1 NC_011896.1 dienelactone hydrolase 1739226 7326880 MLBr_01444 Mycobacterium leprae Br4923 dienelactone hydrolase YP_002503650.1 1738528 D 561304 CDS YP_002503651.1 221230235 7326881 complement(1739584..1739808) 1 NC_011896.1 hypothetical protein 1739808 7326881 MLBr_01445 Mycobacterium leprae Br4923 hypothetical protein YP_002503651.1 1739584 R 561304 CDS YP_002503652.1 221230236 7326882 complement(1740031..1740417) 1 NC_011896.1 hypothetical protein 1740417 7326882 MLBr_01446 Mycobacterium leprae Br4923 hypothetical protein YP_002503652.1 1740031 R 561304 CDS YP_002503653.1 221230237 7326122 1740837..1741391 1 NC_011896.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 1741391 7326122 MLBr_01448 Mycobacterium leprae Br4923 RNA polymerase sigma factor SigC YP_002503653.1 1740837 D 561304 CDS YP_002503654.1 221230238 7326885 complement(1746816..1747490) 1 NC_011896.1 phosphoglycerate mutase 1747490 7326885 MLBr_01452 Mycobacterium leprae Br4923 phosphoglycerate mutase YP_002503654.1 1746816 R 561304 CDS YP_002503655.1 221230239 7326886 complement(1747490..1747879) 1 NC_011896.1 hypothetical protein 1747879 7326886 MLBr_01453 Mycobacterium leprae Br4923 hypothetical protein YP_002503655.1 1747490 R 561304 CDS YP_002503656.1 221230240 7326887 complement(1747876..1748520) 1 NC_011896.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1748520 nadD 7326887 nadD Mycobacterium leprae Br4923 nicotinic acid mononucleotide adenylyltransferase YP_002503656.1 1747876 R 561304 CDS YP_002503657.1 221230241 7326891 complement(1751680..1752909) 1 NC_011896.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1752909 proA 7326891 proA Mycobacterium leprae Br4923 gamma-glutamyl phosphate reductase YP_002503657.1 1751680 R 561304 CDS YP_002503658.1 221230242 7326894 complement(1759234..1761276) 1 NC_011896.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1761276 nadE 7326894 nadE Mycobacterium leprae Br4923 NAD synthetase YP_002503658.1 1759234 R 561304 CDS YP_002503659.1 221230243 7326895 complement(1761493..1762596) 1 NC_011896.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1762596 proB 7326895 proB Mycobacterium leprae Br4923 gamma-glutamyl kinase YP_002503659.1 1761493 R 561304 CDS YP_002503660.1 221230244 7325009 complement(1762600..1764039) 1 NC_011896.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1764039 obgE 7325009 obgE Mycobacterium leprae Br4923 GTPase ObgE YP_002503660.1 1762600 R 561304 CDS YP_002503661.1 221230245 7326896 complement(1764154..1764420) 1 NC_011896.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1764420 rpmA 7326896 rpmA Mycobacterium leprae Br4923 50S ribosomal protein L27 YP_002503661.1 1764154 R 561304 CDS YP_002503662.1 221230246 7326664 complement(1764432..1764743) 1 NC_011896.1 50S ribosomal protein L21 1764743 rplU 7326664 rplU Mycobacterium leprae Br4923 50S ribosomal protein L21 YP_002503662.1 1764432 R 561304 CDS YP_002503663.1 221230247 7326659 complement(1764970..1767744) 1 NC_011896.1 ribonuclease 1767744 7326659 MLBr_01468 Mycobacterium leprae Br4923 ribonuclease YP_002503663.1 1764970 R 561304 CDS YP_002503664.1 221230248 7326897 complement(1768087..1768497) 1 NC_011896.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1768497 ndk 7326897 ndk Mycobacterium leprae Br4923 nucleoside diphosphate kinase YP_002503664.1 1768087 R 561304 CDS YP_002503665.1 221230249 7324958 complement(1768547..1768918) 1 NC_011896.1 hypothetical protein 1768918 7324958 MLBr_01470 Mycobacterium leprae Br4923 hypothetical protein YP_002503665.1 1768547 R 561304 CDS YP_002503666.1 221230250 7326898 complement(1768915..1770372) 1 NC_011896.1 folylpolyglutamate synthase 1770372 folC 7326898 folC Mycobacterium leprae Br4923 folylpolyglutamate synthase YP_002503666.1 1768915 R 561304 CDS YP_002503667.1 221230251 7325302 complement(1770369..1773029) 1 NC_011896.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1773029 valS 7325302 valS Mycobacterium leprae Br4923 valyl-tRNA synthetase YP_002503667.1 1770369 R 561304 CDS YP_002503668.1 221230252 7326902 complement(1779702..1780982) 1 NC_011896.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1780982 clpX 7326902 clpX Mycobacterium leprae Br4923 ATP-dependent protease ATP-binding subunit ClpX YP_002503668.1 1779702 R 561304 CDS YP_002503669.1 221230253 7326765 1781255..1782136 1 NC_011896.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 1782136 mmuM 7326765 mmuM Mycobacterium leprae Br4923 homocysteine methyltransferase YP_002503669.1 1781255 D 561304 CDS YP_002503670.1 221230254 7326903 complement(1782133..1782777) 1 NC_011896.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1782777 clpP2 7326903 clpP2 Mycobacterium leprae Br4923 ATP-dependent Clp protease proteolytic subunit YP_002503670.1 1782133 R 561304 CDS YP_002503671.1 221230255 7327276 complement(1782774..1783448) 1 NC_011896.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1783448 clpP 7327276 clpP Mycobacterium leprae Br4923 ATP-dependent Clp protease proteolytic subunit YP_002503671.1 1782774 R 561304 CDS YP_002503672.1 221230256 7327275 complement(1783500..1784909) 1 NC_011896.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1784909 tig 7327275 tig Mycobacterium leprae Br4923 trigger factor YP_002503672.1 1783500 R 561304 CDS YP_002503673.1 221230257 7326905 complement(1787315..1787803) 1 NC_011896.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 1787803 7326905 MLBr_01484 Mycobacterium leprae Br4923 ribose-5-phosphate isomerase B YP_002503673.1 1787315 R 561304 CDS YP_002503674.1 221230258 7326906 complement(1787844..1788467) 1 NC_011896.1 hypothetical protein 1788467 7326906 MLBr_01485 Mycobacterium leprae Br4923 hypothetical protein YP_002503674.1 1787844 R 561304 CDS YP_002503675.1 221230259 7326907 1788599..1791187 1 NC_011896.1 aminopeptidase 1791187 7326907 MLBr_01486 Mycobacterium leprae Br4923 aminopeptidase YP_002503675.1 1788599 D 561304 CDS YP_002503676.1 221230260 7326909 complement(1792887..1793990) 1 NC_011896.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1793990 7326909 MLBr_01488 Mycobacterium leprae Br4923 N-succinyldiaminopimelate aminotransferase YP_002503676.1 1792887 R 561304 CDS YP_002503677.1 221230261 7326910 complement(1794028..1794354) 1 NC_011896.1 ferredoxin 1794354 fdxA 7326910 fdxA Mycobacterium leprae Br4923 ferredoxin YP_002503677.1 1794028 R 561304 CDS YP_002503678.1 221230262 7326911 complement(1797541..1800132) 1 NC_011896.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1800132 fbiC 7326911 fbiC Mycobacterium leprae Br4923 FO synthase YP_002503678.1 1797541 R 561304 CDS YP_002503679.1 221230263 7327368 complement(1801299..1801652) 1 NC_011896.1 hypothetical protein 1801652 7327368 MLBr_01494 Mycobacterium leprae Br4923 hypothetical protein YP_002503679.1 1801299 R 561304 CDS YP_002503680.1 221230264 7326913 complement(1801817..1802743) 1 NC_011896.1 hypothetical protein 1802743 7326913 MLBr_01495 Mycobacterium leprae Br4923 hypothetical protein YP_002503680.1 1801817 R 561304 CDS YP_002503681.1 221230265 7326915 complement(1803550..1805403) 1 NC_011896.1 hypothetical protein 1805403 7326915 MLBr_01497 Mycobacterium leprae Br4923 hypothetical protein YP_002503681.1 1803550 R 561304 CDS YP_002503682.1 221230266 7326916 complement(1805470..1807356) 1 NC_011896.1 GTP-binding, protein elongation factor 1807356 7326916 MLBr_01498 Mycobacterium leprae Br4923 GTP-binding, protein elongation factor YP_002503682.1 1805470 R 561304 CDS YP_002503683.1 221230267 7324944 1815020..1815304 1 NC_011896.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1815304 phhB 7324944 phhB Mycobacterium leprae Br4923 pterin-4-alpha-carbinolamine dehydratase YP_002503683.1 1815020 D 561304 CDS YP_002503684.1 221230268 7326918 complement(1815291..1816583) 1 NC_011896.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1816583 pimE 7326918 pimE Mycobacterium leprae Br4923 mannosyltransferase YP_002503684.1 1815291 R 561304 CDS YP_002503685.1 221230269 7326919 1816687..1817229 1 NC_011896.1 hypothetical protein 1817229 7326919 MLBr_01505 Mycobacterium leprae Br4923 hypothetical protein YP_002503685.1 1816687 D 561304 CDS YP_002503686.1 221230270 7326920 1817257..1818303 1 NC_011896.1 hypothetical protein 1818303 7326920 MLBr_01506 Mycobacterium leprae Br4923 hypothetical protein YP_002503686.1 1817257 D 561304 CDS YP_002503687.1 221230271 7326922 complement(1819480..1819971) 1 NC_011896.1 hypothetical protein 1819971 7326922 MLBr_01508 Mycobacterium leprae Br4923 hypothetical protein YP_002503687.1 1819480 R 561304 CDS YP_002503688.1 221230272 7326925 1821166..1821879 1 NC_011896.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1821879 7326925 MLBr_01511 Mycobacterium leprae Br4923 NAD-dependent deacetylase YP_002503688.1 1821166 D 561304 CDS YP_002503689.1 221230273 7326926 complement(1822854..1824530) 1 NC_011896.1 hypothetical protein 1824530 7326926 MLBr_01512 Mycobacterium leprae Br4923 hypothetical protein YP_002503689.1 1822854 R 561304 CDS YP_002503690.1 221230274 7326927 complement(1824550..1825452) 1 NC_011896.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1825452 dapA 7326927 dapA Mycobacterium leprae Br4923 dihydrodipicolinate synthase YP_002503690.1 1824550 R 561304 CDS YP_002503691.1 221230275 7326158 complement(1825568..1826332) 1 NC_011896.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 1826332 thyX 7326158 thyX Mycobacterium leprae Br4923 FAD-dependent thymidylate synthase YP_002503691.1 1825568 R 561304 CDS YP_002503692.1 221230276 7324695 complement(1831316..1831597) 1 NC_011896.1 hypothetical protein 1831597 7324695 MLBr_01517 Mycobacterium leprae Br4923 hypothetical protein YP_002503692.1 1831316 R 561304 CDS YP_002503693.1 221230277 7325707 complement(1832399..1832896) 1 NC_011896.1 dihydrofolate reductase 1832896 folA 7325707 folA Mycobacterium leprae Br4923 dihydrofolate reductase YP_002503693.1 1832399 R 561304 CDS YP_002503694.1 221230278 7325300 complement(1832949..1833749) 1 NC_011896.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1833749 thyA 7325300 thyA Mycobacterium leprae Br4923 thymidylate synthase YP_002503694.1 1832949 R 561304 CDS YP_002503695.1 221230279 7325235 complement(1837743..1838033) 1 NC_011896.1 hypothetical protein 1838033 7325235 MLBr_01523 Mycobacterium leprae Br4923 hypothetical protein YP_002503695.1 1837743 R 561304 CDS YP_002503696.1 221230280 7325711 complement(1839934..1840389) 1 NC_011896.1 hypothetical protein 1840389 7325711 MLBr_01525 Mycobacterium leprae Br4923 hypothetical protein YP_002503696.1 1839934 R 561304 CDS YP_002503697.1 221230281 7325712 complement(1840397..1840879) 1 NC_011896.1 hypothetical protein 1840879 7325712 MLBr_01526 Mycobacterium leprae Br4923 hypothetical protein YP_002503697.1 1840397 R 561304 CDS YP_002503698.1 221230282 7325717 1846890..1848005 1 NC_011896.1 L-alanine dehydrogenase 1848005 ald 7325717 ald Mycobacterium leprae Br4923 L-alanine dehydrogenase YP_002503698.1 1846890 D 561304 CDS YP_002503699.1 221230283 7325718 complement(1851655..1853487) 1 NC_011896.1 hypothetical protein 1853487 7325718 MLBr_01536 Mycobacterium leprae Br4923 hypothetical protein YP_002503699.1 1851655 R 561304 CDS YP_002503700.1 221230284 7325719 complement(1853484..1854689) 1 NC_011896.1 hypothetical protein 1854689 7325719 MLBr_01537 Mycobacterium leprae Br4923 hypothetical protein YP_002503700.1 1853484 R 561304 CDS YP_002503701.1 221230285 7325720 complement(1854710..1856413) 1 NC_011896.1 protease 1856413 7325720 MLBr_01538 Mycobacterium leprae Br4923 protease YP_002503701.1 1854710 R 561304 CDS YP_002503702.1 221230286 7325721 complement(1856445..1857956) 1 NC_011896.1 hypothetical protein 1857956 7325721 MLBr_01539 Mycobacterium leprae Br4923 hypothetical protein YP_002503702.1 1856445 R 561304 CDS YP_002503703.1 221230287 7325722 complement(1858220..1859122) 1 NC_011896.1 hypothetical protein 1859122 7325722 MLBr_01540 Mycobacterium leprae Br4923 hypothetical protein YP_002503703.1 1858220 R 561304 CDS YP_002503704.1 221230288 7325725 complement(1862140..1866177) 1 NC_011896.1 SpoIIIE-family membrane protein 1866177 7325725 MLBr_01543 Mycobacterium leprae Br4923 SpoIIIE-family membrane protein YP_002503704.1 1862140 R 561304 CDS YP_002503705.1 221230289 7325726 complement(1866294..1867814) 1 NC_011896.1 hypothetical protein 1867814 7325726 MLBr_01544 Mycobacterium leprae Br4923 hypothetical protein YP_002503705.1 1866294 R 561304 CDS YP_002503706.1 221230290 7325728 complement(1870924..1871886) 1 NC_011896.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1871886 truB 7325728 truB Mycobacterium leprae Br4923 tRNA pseudouridine synthase B YP_002503706.1 1870924 R 561304 CDS YP_002503707.1 221230291 7327288 complement(1871883..1872566) 1 NC_011896.1 hypothetical protein 1872566 7327288 MLBr_01547 Mycobacterium leprae Br4923 hypothetical protein YP_002503707.1 1871883 R 561304 CDS YP_002503708.1 221230292 7325729 complement(1872563..1873528) 1 NC_011896.1 hypothetical protein 1873528 7325729 MLBr_01548 Mycobacterium leprae Br4923 hypothetical protein YP_002503708.1 1872563 R 561304 CDS YP_002503709.1 221230293 7325213 1877167..1878609 1 NC_011896.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1878609 proS 7325213 proS Mycobacterium leprae Br4923 prolyl-tRNA synthetase YP_002503709.1 1877167 D 561304 CDS YP_002503710.1 221230294 7325734 complement(1879594..1880088) 1 NC_011896.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1880088 rbfA 7325734 rbfA Mycobacterium leprae Br4923 ribosome-binding factor A YP_002503710.1 1879594 R 561304 CDS YP_002503711.1 221230295 7325735 complement(1880102..1882876) 1 NC_011896.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1882876 infB 7325735 infB Mycobacterium leprae Br4923 translation initiation factor IF-2 YP_002503711.1 1880102 R 561304 CDS YP_002503712.1 221230296 7324718 complement(1882941..1883261) 1 NC_011896.1 hypothetical protein 1883261 7324718 MLBr_01557 Mycobacterium leprae Br4923 hypothetical protein YP_002503712.1 1882941 R 561304 CDS YP_002503713.1 221230297 7325736 complement(1883461..1884504) 1 NC_011896.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1884504 nusA 7325736 nusA Mycobacterium leprae Br4923 transcription elongation factor NusA YP_002503713.1 1883461 R 561304 CDS YP_002503714.1 221230298 7325737 1885164..1885700 1 NC_011896.1 hypothetical protein 1885700 7325737 MLBr_01560 Mycobacterium leprae Br4923 hypothetical protein YP_002503714.1 1885164 D 561304 CDS YP_002503715.1 221230299 7325738 1885697..1886194 1 NC_011896.1 hypothetical protein 1886194 7325738 MLBr_01561 Mycobacterium leprae Br4923 hypothetical protein YP_002503715.1 1885697 D 561304 CDS YP_002503716.1 221230300 7325739 complement(1886219..1887823) 1 NC_011896.1 transmembrane efflux protein 1887823 7325739 MLBr_01562 Mycobacterium leprae Br4923 transmembrane efflux protein YP_002503716.1 1886219 R 561304 CDS YP_002503717.1 221230301 7324959 1898049..1898447 1 NC_011896.1 hypothetical protein 1898447 7324959 MLBr_01572 Mycobacterium leprae Br4923 hypothetical protein YP_002503717.1 1898049 D 561304 CDS YP_002503718.1 221230302 7325745 complement(1898908..1899657) 1 NC_011896.1 amidotransferase 1899657 7325745 MLBr_01573 Mycobacterium leprae Br4923 amidotransferase YP_002503718.1 1898908 R 561304 CDS YP_002503719.1 221230303 7325352 complement(1900094..1900387) 1 NC_011896.1 hypothetical protein 1900387 7325352 MLBr_01575 Mycobacterium leprae Br4923 hypothetical protein YP_002503719.1 1900094 R 561304 CDS YP_002503720.1 221230304 7325747 complement(1900811..1901668) 1 NC_011896.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 1901668 mapB 7325747 mapB Mycobacterium leprae Br4923 methionine aminopeptidase YP_002503720.1 1900811 R 561304 CDS YP_002503721.1 221230305 7325437 complement(1901860..1903686) 1 NC_011896.1 penicillin binding protein 1903686 7325437 MLBr_01577 Mycobacterium leprae Br4923 penicillin binding protein YP_002503721.1 1901860 R 561304 CDS YP_002503722.1 221230306 7325751 complement(1905686..1906864) 1 NC_011896.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1906864 ispG 7325751 ispG Mycobacterium leprae Br4923 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002503722.1 1905686 R 561304 CDS YP_002503723.1 221230307 7325335 complement(1906917..1908131) 1 NC_011896.1 integral membrane protein 1908131 7325335 MLBr_01582 Mycobacterium leprae Br4923 integral membrane protein YP_002503723.1 1906917 R 561304 CDS YP_002503724.1 221230308 7325752 complement(1908140..1909360) 1 NC_011896.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1909360 7325752 MLBr_01583 Mycobacterium leprae Br4923 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002503724.1 1908140 R 561304 CDS YP_002503725.1 221230309 7325753 1909515..1909769 1 NC_011896.1 hypothetical protein 1909769 7325753 MLBr_01584 Mycobacterium leprae Br4923 hypothetical protein YP_002503725.1 1909515 D 561304 CDS YP_002503726.1 221230310 7325757 complement(1913823..1914761) 1 NC_011896.1 phosphatidate cytidylyltransferase 1914761 7325757 MLBr_01589 Mycobacterium leprae Br4923 phosphatidate cytidylyltransferase YP_002503726.1 1913823 R 561304 CDS YP_002503727.1 221230311 7325758 complement(1914793..1915350) 1 NC_011896.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1915350 frr 7325758 frr Mycobacterium leprae Br4923 ribosome recycling factor YP_002503727.1 1914793 R 561304 CDS YP_002503728.1 221230312 7325311 complement(1915409..1916248) 1 NC_011896.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1916248 pyrH 7325311 pyrH Mycobacterium leprae Br4923 uridylate kinase YP_002503728.1 1915409 R 561304 CDS YP_002503729.1 221230313 7325763 complement(1920839..1922245) 1 NC_011896.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1922245 7325763 MLBr_01596 Mycobacterium leprae Br4923 amidase YP_002503729.1 1920839 R 561304 CDS YP_002503730.1 221230314 7325764 complement(1922281..1923111) 1 NC_011896.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1923111 tsf 7325764 tsf Mycobacterium leprae Br4923 elongation factor Ts YP_002503730.1 1922281 R 561304 CDS YP_002503731.1 221230315 7327291 complement(1923113..1923946) 1 NC_011896.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1923946 rpsB 7327291 rpsB Mycobacterium leprae Br4923 30S ribosomal protein S2 YP_002503731.1 1923113 R 561304 CDS YP_002503732.1 221230316 7325765 complement(1924770..1925663) 1 NC_011896.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1925663 xerC 7325765 xerC Mycobacterium leprae Br4923 site-specific tyrosine recombinase XerC YP_002503732.1 1924770 R 561304 CDS YP_002503733.1 221230317 7327320 complement(1926680..1927045) 1 NC_011896.1 hypothetical protein 1927045 7327320 MLBr_01601 Mycobacterium leprae Br4923 hypothetical protein YP_002503733.1 1926680 R 561304 CDS YP_002503734.1 221230318 7325766 complement(1927729..1928049) 1 NC_011896.1 hypothetical protein 1928049 7325766 MLBr_01602 Mycobacterium leprae Br4923 hypothetical protein YP_002503734.1 1927729 R 561304 CDS YP_002503735.1 221230319 7325767 complement(1928302..1928562) 1 NC_011896.1 hypothetical protein 1928562 7325767 MLBr_01603 Mycobacterium leprae Br4923 hypothetical protein YP_002503735.1 1928302 R 561304 CDS YP_002503736.1 221230320 7325768 complement(1928772..1929161) 1 NC_011896.1 hypothetical protein 1929161 7325768 MLBr_01604 Mycobacterium leprae Br4923 hypothetical protein YP_002503736.1 1928772 R 561304 CDS YP_002503737.1 221230321 7325769 1931132..1931332 1 NC_011896.1 hypothetical protein 1931332 7325769 MLBr_01605 Mycobacterium leprae Br4923 hypothetical protein YP_002503737.1 1931132 D 561304 CDS YP_002503738.1 221230322 7325771 complement(1932626..1932916) 1 NC_011896.1 hypothetical protein 1932916 7325771 MLBr_01607 Mycobacterium leprae Br4923 hypothetical protein YP_002503738.1 1932626 R 561304 CDS YP_002503739.1 221230323 7325293 complement(1934946..1935251) 1 NC_011896.1 hypothetical protein 1935251 7325293 MLBr_01610 Mycobacterium leprae Br4923 hypothetical protein YP_002503739.1 1934946 R 561304 CDS YP_002503740.1 221230324 7325773 complement(1935364..1936086) 1 NC_011896.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1936086 rnhB 7325773 rnhB Mycobacterium leprae Br4923 ribonuclease HII YP_002503740.1 1935364 R 561304 CDS YP_002503741.1 221230325 7326633 complement(1936089..1936958) 1 NC_011896.1 ignal peptidase I 1936958 7326633 MLBr_01612 Mycobacterium leprae Br4923 ignal peptidase I YP_002503741.1 1936089 R 561304 CDS YP_002503742.1 221230326 7325774 complement(1937038..1937379) 1 NC_011896.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1937379 rplS 7325774 rplS Mycobacterium leprae Br4923 50S ribosomal protein L19 YP_002503742.1 1937038 R 561304 CDS YP_002503743.1 221230327 7325412 complement(1938665..1939381) 1 NC_011896.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1939381 trmD 7325412 trmD Mycobacterium leprae Br4923 tRNA (guanine-N(1)-)-methyltransferase YP_002503743.1 1938665 R 561304 CDS YP_002503744.1 221230328 7327279 complement(1939378..1939917) 1 NC_011896.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1939917 rimM 7327279 rimM Mycobacterium leprae Br4923 16S rRNA-processing protein RimM YP_002503744.1 1939378 R 561304 CDS YP_002503745.1 221230329 7326626 complement(1939922..1940164) 1 NC_011896.1 hypothetical protein 1940164 7326626 MLBr_01617 Mycobacterium leprae Br4923 hypothetical protein YP_002503745.1 1939922 R 561304 CDS YP_002503746.1 221230330 7325775 complement(1940189..1940671) 1 NC_011896.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1940671 rpsP 7325775 rpsP Mycobacterium leprae Br4923 30S ribosomal protein S16 YP_002503746.1 1940189 R 561304 CDS YP_002503747.1 221230331 7325777 complement(1943727..1945292) 1 NC_011896.1 signal recognition particle protein 1945292 ffh 7325777 ffh Mycobacterium leprae Br4923 signal recognition particle protein YP_002503747.1 1943727 R 561304 CDS YP_002503748.1 221230332 7325297 1945431..1947401 1 NC_011896.1 molecular chaperone; heat shock protein 90 1947401 htpG 7325297 htpG Mycobacterium leprae Br4923 heat shock protein 90 YP_002503748.1 1945431 D 561304 CDS YP_002503749.1 221230333 7324699 1947563..1949353 1 NC_011896.1 hypothetical protein 1949353 7324699 MLBr_01624 Mycobacterium leprae Br4923 hypothetical protein YP_002503749.1 1947563 D 561304 CDS YP_002503750.1 221230334 7327209 complement(1953374..1954666) 1 NC_011896.1 SRP family of GTP-binding protein 1954666 7327209 MLBr_01628 Mycobacterium leprae Br4923 SRP family of GTP-binding protein YP_002503750.1 1953374 R 561304 CDS YP_002503751.1 221230335 7325779 complement(1954780..1958391) 1 NC_011896.1 cell division protein 1958391 smc 7325779 smc Mycobacterium leprae Br4923 cell division protein YP_002503751.1 1954780 R 561304 CDS YP_002503752.1 221230336 7325995 complement(1959811..1962825) 1 NC_011896.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1962825 glnE 7325995 glnE Mycobacterium leprae Br4923 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002503752.1 1959811 R 561304 CDS YP_002503753.1 221230337 7325355 complement(1962856..1964202) 1 NC_011896.1 glutamine synthase class II 1964202 glnA2 7325355 glnA2 Mycobacterium leprae Br4923 glutamine synthase class II YP_002503753.1 1962856 R 561304 CDS YP_002503754.1 221230338 7325350 complement(1964299..1965834) 1 NC_011896.1 hydrolase 1965834 7325350 MLBr_01632 Mycobacterium leprae Br4923 hydrolase YP_002503754.1 1964299 R 561304 CDS YP_002503755.1 221230339 7325780 complement(1965909..1967516) 1 NC_011896.1 hydrolase 1967516 7325780 MLBr_01633 Mycobacterium leprae Br4923 hydrolase YP_002503755.1 1965909 R 561304 CDS YP_002503756.1 221230340 7325782 1969054..1969914 1 NC_011896.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1969914 panB 7325782 panB Mycobacterium leprae Br4923 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002503756.1 1969054 D 561304 CDS YP_002503757.1 221230341 7327330 complement(1973936..1975051) 1 NC_011896.1 bifunctional RNase H/acid phosphatase 1975051 7327330 MLBr_01637 Mycobacterium leprae Br4923 bifunctional RNase H/acid phosphatase YP_002503757.1 1973936 R 561304 CDS YP_002503758.1 221230342 7325784 complement(1975048..1975746) 1 NC_011896.1 hypothetical protein 1975746 7325784 MLBr_01638 Mycobacterium leprae Br4923 hypothetical protein YP_002503758.1 1975048 R 561304 CDS YP_002503759.1 221230343 7325785 complement(1975792..1976949) 1 NC_011896.1 hypothetical protein 1976949 7325785 MLBr_01639 Mycobacterium leprae Br4923 hypothetical protein YP_002503759.1 1975792 R 561304 CDS YP_002503760.1 221230344 7325030 1978887..1979699 1 NC_011896.1 hypothetical protein 1979699 7325030 MLBr_01644 Mycobacterium leprae Br4923 hypothetical protein YP_002503760.1 1978887 D 561304 CDS YP_002503761.1 221230345 7327197 complement(1987756..1988178) 1 NC_011896.1 hypothetical protein 1988178 7327197 MLBr_01649 Mycobacterium leprae Br4923 hypothetical protein YP_002503761.1 1987756 R 561304 CDS YP_002503762.1 221230346 7326772 1989091..1991901 1 NC_011896.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1991901 aceE 7326772 aceE Mycobacterium leprae Br4923 pyruvate dehydrogenase subunit E1 YP_002503762.1 1989091 D 561304 CDS YP_002503763.1 221230347 7327182 1991987..1993231 1 NC_011896.1 hypothetical protein 1993231 7327182 MLBr_01652 Mycobacterium leprae Br4923 hypothetical protein YP_002503763.1 1991987 D 561304 CDS YP_002503764.1 221230348 7326773 1993442..1994356 1 NC_011896.1 malonyl CoA-[ACP] transacylase 1994356 fabD 7326773 fabD Mycobacterium leprae Br4923 malonyl CoA-[ACP] transacylase YP_002503764.1 1993442 D 561304 CDS YP_002503765.1 221230349 7325232 1994456..1994803 1 NC_011896.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1994803 acpP 7325232 acpP Mycobacterium leprae Br4923 acyl carrier protein YP_002503765.1 1994456 D 561304 CDS YP_002503766.1 221230350 7327185 1994800..1996050 1 NC_011896.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1996050 kasA 7327185 kasA Mycobacterium leprae Br4923 3-oxoacyl-ACP synthase YP_002503766.1 1994800 D 561304 CDS YP_002503767.1 221230351 7324722 1996063..1997340 1 NC_011896.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1997340 kasB 7324722 kasB Mycobacterium leprae Br4923 3-oxoacyl-ACP synthase YP_002503767.1 1996063 D 561304 CDS YP_002503768.1 221230352 7324723 1997371..1998792 1 NC_011896.1 acetyl/propionyl CoA carboxylase subunit beta 1998792 7324723 MLBr_01657 Mycobacterium leprae Br4923 acetyl/propionyl CoA carboxylase subunit beta YP_002503768.1 1997371 D 561304 CDS YP_002503769.1 221230353 7326774 complement(1999918..2000766) 1 NC_011896.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2000766 fpg 7326774 fpg Mycobacterium leprae Br4923 formamidopyrimidine-DNA glycosylase YP_002503769.1 1999918 R 561304 CDS YP_002503770.1 221230354 7325308 complement(2000821..2001537) 1 NC_011896.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2001537 rnc 7325308 rnc Mycobacterium leprae Br4923 ribonuclease III YP_002503770.1 2000821 R 561304 CDS YP_002503771.1 221230355 7326632 complement(2001534..2002187) 1 NC_011896.1 hypothetical protein 2002187 7326632 MLBr_01660 Mycobacterium leprae Br4923 hypothetical protein YP_002503771.1 2001534 R 561304 CDS YP_002503772.1 221230356 7326775 complement(2002221..2002964) 1 NC_011896.1 hypothetical protein 2002964 7326775 MLBr_01661 Mycobacterium leprae Br4923 hypothetical protein YP_002503772.1 2002221 R 561304 CDS YP_002503773.1 221230357 7326777 complement(2005059..2005532) 1 NC_011896.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2005532 coaD 7326777 coaD Mycobacterium leprae Br4923 phosphopantetheine adenylyltransferase YP_002503773.1 2005059 R 561304 CDS YP_002503774.1 221230358 7326115 complement(2005564..2006037) 1 NC_011896.1 hypothetical protein 2006037 7326115 MLBr_01664 Mycobacterium leprae Br4923 hypothetical protein YP_002503774.1 2005564 R 561304 CDS YP_002503775.1 221230359 7327356 complement(2009528..2010172) 1 NC_011896.1 hypothetical protein 2010172 7327356 MLBr_01666 Mycobacterium leprae Br4923 hypothetical protein YP_002503775.1 2009528 R 561304 CDS YP_002503776.1 221230360 7326779 complement(2010181..2010975) 1 NC_011896.1 hypothetical protein 2010975 7326779 MLBr_01667 Mycobacterium leprae Br4923 hypothetical protein YP_002503776.1 2010181 R 561304 CDS YP_002503777.1 221230361 7325397 2012983..2013831 1 NC_011896.1 oxidoreductase 2013831 7325397 MLBr_01669 Mycobacterium leprae Br4923 oxidoreductase YP_002503777.1 2012983 D 561304 CDS YP_002503778.1 221230362 7326782 complement(2014650..2016881) 1 NC_011896.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2016881 recG 7326782 recG Mycobacterium leprae Br4923 ATP-dependent DNA helicase RecG YP_002503778.1 2014650 R 561304 CDS YP_002503779.1 221230363 7326665 complement(2019204..2019887) 1 NC_011896.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2019887 ung 7326665 ung Mycobacterium leprae Br4923 uracil-DNA glycosylase YP_002503779.1 2019204 R 561304 CDS YP_002503780.1 221230364 7327300 complement(2020001..2020978) 1 NC_011896.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2020978 thiL 7327300 thiL Mycobacterium leprae Br4923 thiamine monophosphate kinase YP_002503780.1 2020001 R 561304 CDS YP_002503781.1 221230365 7326017 2021162..2021737 1 NC_011896.1 hypothetical protein 2021737 7326017 MLBr_01677 Mycobacterium leprae Br4923 hypothetical protein YP_002503781.1 2021162 D 561304 CDS YP_002503782.1 221230366 7326785 complement(2021746..2022900) 1 NC_011896.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2022900 ddl 7326785 ddl Mycobacterium leprae Br4923 D-alanyl-alanine synthetase A YP_002503782.1 2021746 R 561304 CDS YP_002503783.1 221230367 7326162 complement(2023012..2024067) 1 NC_011896.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2024067 gpsA 7326162 gpsA Mycobacterium leprae Br4923 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002503783.1 2023012 R 561304 CDS YP_002503784.1 221230368 7324654 2024608..2025258 1 NC_011896.1 hypothetical protein 2025258 7324654 MLBr_01680 Mycobacterium leprae Br4923 hypothetical protein YP_002503784.1 2024608 D 561304 CDS YP_002503785.1 221230369 7326786 2025342..2027561 1 NC_011896.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2027561 7326786 MLBr_01681 Mycobacterium leprae Br4923 polyphosphate kinase YP_002503785.1 2025342 D 561304 CDS YP_002503786.1 221230370 7326787 2027640..2028575 1 NC_011896.1 hypothetical protein 2028575 7326787 MLBr_01682 Mycobacterium leprae Br4923 hypothetical protein YP_002503786.1 2027640 D 561304 CDS YP_002503787.1 221230371 7326788 complement(2028644..2029246) 1 NC_011896.1 histone-like protein 2029246 7326788 MLBr_01683 Mycobacterium leprae Br4923 histone-like protein YP_002503787.1 2028644 R 561304 CDS YP_002503788.1 221230372 7326789 complement(2029460..2030056) 1 NC_011896.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2030056 leuD 7326789 leuD Mycobacterium leprae Br4923 isopropylmalate isomerase small subunit YP_002503788.1 2029460 R 561304 CDS YP_002503789.1 221230373 7324731 complement(2030099..2031556) 1 NC_011896.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2031556 leuC 7324731 leuC Mycobacterium leprae Br4923 isopropylmalate isomerase large subunit YP_002503789.1 2030099 R 561304 CDS YP_002503790.1 221230374 7325359 complement(2033511..2035019) 1 NC_011896.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2035019 gltX 7325359 gltX Mycobacterium leprae Br4923 glutamyl-tRNA synthetase YP_002503790.1 2033511 R 561304 CDS YP_002503791.1 221230375 7325368 complement(2035016..2035744) 1 NC_011896.1 hydrolase 2035744 7325368 MLBr_01689 Mycobacterium leprae Br4923 hydrolase YP_002503791.1 2035016 R 561304 CDS YP_002503792.1 221230376 7326793 complement(2037082..2038092) 1 NC_011896.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2038092 leuB 7326793 leuB Mycobacterium leprae Br4923 3-isopropylmalate dehydrogenase YP_002503792.1 2037082 R 561304 CDS YP_002503793.1 221230377 7324729 complement(2038142..2039728) 1 NC_011896.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2039728 serA 7324729 serA Mycobacterium leprae Br4923 D-3-phosphoglycerate dehydrogenase YP_002503793.1 2038142 R 561304 CDS YP_002503794.1 221230378 7326794 complement(2042647..2043648) 1 NC_011896.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2043648 ilvC 7326794 ilvC Mycobacterium leprae Br4923 ketol-acid reductoisomerase YP_002503794.1 2042647 R 561304 CDS YP_002503795.1 221230379 7324710 complement(2043701..2044210) 1 NC_011896.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 2044210 ilvH 7324710 ilvH Mycobacterium leprae Br4923 acetolactate synthase 3 regulatory subunit YP_002503795.1 2043701 R 561304 CDS YP_002503796.1 221230380 7324714 complement(2044262..2046139) 1 NC_011896.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 2046139 ilvB 7324714 ilvB Mycobacterium leprae Br4923 acetolactate synthase 1 catalytic subunit YP_002503796.1 2044262 R 561304 CDS YP_002503797.1 221230381 7326795 complement(2046911..2047744) 1 NC_011896.1 hypothetical protein 2047744 7326795 MLBr_01698 Mycobacterium leprae Br4923 hypothetical protein YP_002503797.1 2046911 R 561304 CDS YP_002503798.1 221230382 7326796 2047987..2049105 1 NC_011896.1 lipoprotein 2049105 7326796 MLBr_01699 Mycobacterium leprae Br4923 lipoprotein YP_002503798.1 2047987 D 561304 CDS YP_002503799.1 221230383 7326797 complement(2050047..2051576) 1 NC_011896.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2051576 gatB 7326797 gatB Mycobacterium leprae Br4923 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002503799.1 2050047 R 561304 CDS YP_002503800.1 221230384 7325332 complement(2051925..2052956) 1 NC_011896.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 2052956 pfkA 7325332 pfkA Mycobacterium leprae Br4923 6-phosphofructokinase YP_002503800.1 2051925 R 561304 CDS YP_002503801.1 221230385 7327381 complement(2053044..2054537) 1 NC_011896.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2054537 gatA 7327381 gatA Mycobacterium leprae Br4923 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002503801.1 2053044 R 561304 CDS YP_002503802.1 221230386 7325331 complement(2054534..2054833) 1 NC_011896.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2054833 gatC 7325331 gatC Mycobacterium leprae Br4923 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002503802.1 2054534 R 561304 CDS YP_002503803.1 221230387 7325333 2054970..2055668 1 NC_011896.1 hypothetical protein 2055668 7325333 MLBr_01704 Mycobacterium leprae Br4923 hypothetical protein YP_002503803.1 2054970 D 561304 CDS YP_002503804.1 221230388 7326798 complement(2055671..2057755) 1 NC_011896.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2057755 ligA 7326798 ligA Mycobacterium leprae Br4923 NAD-dependent DNA ligase LigA YP_002503804.1 2055671 R 561304 CDS YP_002503805.1 221230389 7325385 complement(2057814..2058827) 1 NC_011896.1 hypothetical protein 2058827 7325385 MLBr_01706 Mycobacterium leprae Br4923 hypothetical protein YP_002503805.1 2057814 R 561304 CDS YP_002503806.1 221230390 7326799 complement(2059743..2060819) 1 NC_011896.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2060819 mnmA 7326799 mnmA Mycobacterium leprae Br4923 tRNA-specific 2-thiouridylase MnmA YP_002503806.1 2059743 R 561304 CDS YP_002503807.1 221230391 7326800 complement(2060816..2062048) 1 NC_011896.1 aminotransferase 2062048 7326800 MLBr_01708 Mycobacterium leprae Br4923 aminotransferase YP_002503807.1 2060816 R 561304 CDS YP_002503808.1 221230392 7326803 complement(2064002..2064958) 1 NC_011896.1 electron transfer flavoprotein alpha subunit 2064958 eftA 7326803 eftA Mycobacterium leprae Br4923 electron transfer flavoprotein alpha subunit YP_002503808.1 2064002 R 561304 CDS YP_002503809.1 221230393 7325222 complement(2065007..2065807) 1 NC_011896.1 electron transfer flavoprotein subunit beta 2065807 eftB 7325222 eftB Mycobacterium leprae Br4923 electron transfer flavoprotein subunit beta YP_002503809.1 2065007 R 561304 CDS YP_002503810.1 221230394 7325223 2066035..2066877 1 NC_011896.1 hypothetical protein 2066877 7325223 MLBr_01713 Mycobacterium leprae Br4923 hypothetical protein YP_002503810.1 2066035 D 561304 CDS YP_002503811.1 221230395 7326804 2066874..2068442 1 NC_011896.1 hypothetical protein 2068442 7326804 MLBr_01714 Mycobacterium leprae Br4923 hypothetical protein YP_002503811.1 2066874 D 561304 CDS YP_002503812.1 221230396 7326805 2068468..2069784 1 NC_011896.1 transferase 2069784 7326805 MLBr_01715 Mycobacterium leprae Br4923 transferase YP_002503812.1 2068468 D 561304 CDS YP_002503813.1 221230397 7326807 complement(2071280..2071573) 1 NC_011896.1 hypothetical protein 2071573 7326807 MLBr_01717 Mycobacterium leprae Br4923 hypothetical protein YP_002503813.1 2071280 R 561304 CDS YP_002503814.1 221230398 7326809 complement(2074851..2075588) 1 NC_011896.1 hypothetical protein 2075588 7326809 MLBr_01719 Mycobacterium leprae Br4923 hypothetical protein YP_002503814.1 2074851 R 561304 CDS YP_002503815.1 221230399 7326810 2076028..2077122 1 NC_011896.1 hypothetical protein 2077122 7326810 MLBr_01720 Mycobacterium leprae Br4923 hypothetical protein YP_002503815.1 2076028 D 561304 CDS YP_002503816.1 221230400 7326813 complement(2079702..2080685) 1 NC_011896.1 hypothetical protein 2080685 7326813 MLBr_01723 Mycobacterium leprae Br4923 hypothetical protein YP_002503816.1 2079702 R 561304 CDS YP_002503817.1 221230401 7326814 complement(2080718..2081476) 1 NC_011896.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2081476 7326814 MLBr_01724 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002503817.1 2080718 R 561304 CDS YP_002503818.1 221230402 7326816 complement(2082348..2083265) 1 NC_011896.1 ABC transporter protein, ATP-binding component 2083265 7326816 MLBr_01726 Mycobacterium leprae Br4923 ABC transporter protein, ATP-binding component YP_002503818.1 2082348 R 561304 CDS YP_002503819.1 221230403 7326817 complement(2083275..2084510) 1 NC_011896.1 phosphoserine phosphatase 2084510 7326817 MLBr_01727 Mycobacterium leprae Br4923 phosphoserine phosphatase YP_002503819.1 2083275 R 561304 CDS YP_002503820.1 221230404 7326818 complement(2084550..2086274) 1 NC_011896.1 cytochrome C oxidase, polypeptide I 2086274 7326818 MLBr_01728 Mycobacterium leprae Br4923 cytochrome C oxidase, polypeptide I YP_002503820.1 2084550 R 561304 CDS YP_002503821.1 221230405 7326819 2086489..2087583 1 NC_011896.1 FeIII-dicitrate transporter lipoprotein 2087583 fecB 7326819 fecB Mycobacterium leprae Br4923 FeIII-dicitrate transporter lipoprotein YP_002503821.1 2086489 D 561304 CDS YP_002503822.1 221230406 7325295 2087843..2088931 1 NC_011896.1 alcohol dehydrogenase 2088931 adhA 7325295 adhA Mycobacterium leprae Br4923 alcohol dehydrogenase YP_002503822.1 2087843 D 561304 CDS YP_002503823.1 221230407 7327189 complement(2090540..2091517) 1 NC_011896.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2091517 nrdF 7327189 nrdF Mycobacterium leprae Br4923 ribonucleotide-diphosphate reductase subunit beta YP_002503823.1 2090540 R 561304 CDS YP_002503824.1 221230408 7326820 complement(2093377..2094204) 1 NC_011896.1 TetR family transcriptional regulator 2094204 7326820 MLBr_01733 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002503824.1 2093377 R 561304 CDS YP_002503825.1 221230409 7326821 complement(2094251..2096332) 1 NC_011896.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2096332 nrdE 7326821 nrdE Mycobacterium leprae Br4923 ribonucleotide-diphosphate reductase subunit alpha YP_002503825.1 2094251 R 561304 CDS YP_002503826.1 221230410 7324963 complement(2096417..2096833) 1 NC_011896.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2096833 nrdI 7324963 nrdI Mycobacterium leprae Br4923 ribonucleotide reductase stimulatory protein YP_002503826.1 2096417 R 561304 CDS YP_002503827.1 221230411 7324966 complement(2096862..2097104) 1 NC_011896.1 glutaredoxin electron transport component of NrdEF 2097104 nrdH 7324966 nrdH Mycobacterium leprae Br4923 glutaredoxin electron transport component of NrdEF YP_002503827.1 2096862 R 561304 CDS YP_002503828.1 221230412 7326172 complement(2099908..2100846) 1 NC_011896.1 short chain dehydrogenase 2100846 7326172 MLBr_01740 Mycobacterium leprae Br4923 short chain dehydrogenase YP_002503828.1 2099908 R 561304 CDS YP_002503829.1 221230413 7326829 complement(2115048..2116919) 1 NC_011896.1 hypothetical protein 2116919 7326829 MLBr_01750 Mycobacterium leprae Br4923 hypothetical protein YP_002503829.1 2115048 R 561304 CDS YP_002503830.1 221230414 7326830 complement(2116937..2119102) 1 NC_011896.1 hypothetical protein 2119102 7326830 MLBr_01751 Mycobacterium leprae Br4923 hypothetical protein YP_002503830.1 2116937 R 561304 CDS YP_002503831.1 221230415 7326831 complement(2121246..2122154) 1 NC_011896.1 hypothetical protein 2122154 7326831 MLBr_01752 Mycobacterium leprae Br4923 hypothetical protein YP_002503831.1 2121246 R 561304 CDS YP_002503832.1 221230416 7326832 complement(2123695..2127015) 1 NC_011896.1 transcriptional regulator 2127015 7326832 MLBr_01753 Mycobacterium leprae Br4923 transcriptional regulator YP_002503832.1 2123695 R 561304 CDS YP_002503833.1 221230417 7326834 complement(2129584..2130960) 1 NC_011896.1 L-serine dehydratase 2130960 sdaA 7326834 sdaA Mycobacterium leprae Br4923 L-serine dehydratase YP_002503833.1 2129584 R 561304 CDS YP_002503834.1 221230418 7325968 2131218..2131541 1 NC_011896.1 multidrug resistance protein 2131541 7325968 MLBr_01756 Mycobacterium leprae Br4923 multidrug resistance protein YP_002503834.1 2131218 D 561304 CDS YP_002503835.1 221230419 7326838 complement(2135954..2136298) 1 NC_011896.1 hypothetical protein 2136298 7326838 MLBr_01761 Mycobacterium leprae Br4923 hypothetical protein YP_002503835.1 2135954 R 561304 CDS YP_002503836.1 221230420 7326840 2138690..2138905 1 NC_011896.1 hypothetical protein 2138905 7326840 MLBr_01763 Mycobacterium leprae Br4923 hypothetical protein YP_002503836.1 2138690 D 561304 CDS YP_002503837.1 221230421 7326845 2143203..2144189 1 NC_011896.1 sugar transport integral membrane protein 2144189 uspA 7326845 uspA Mycobacterium leprae Br4923 sugar transport integral membrane protein YP_002503837.1 2143203 D 561304 CDS YP_002503838.1 221230422 7327302 2144176..2145000 1 NC_011896.1 sugar transport integral membrane protein 2145000 uspE 7327302 uspE Mycobacterium leprae Br4923 sugar transport integral membrane protein YP_002503838.1 2144176 D 561304 CDS YP_002503839.1 221230423 7327304 2145092..2146432 1 NC_011896.1 sugar transport periplasmic binding protein 2146432 uspC 7327304 uspC Mycobacterium leprae Br4923 sugar transport periplasmic binding protein YP_002503839.1 2145092 D 561304 CDS YP_002503840.1 221230424 7325871 complement(2157600..2158112) 1 NC_011896.1 hypothetical protein 2158112 7325871 MLBr_01781 Mycobacterium leprae Br4923 hypothetical protein YP_002503840.1 2157600 R 561304 CDS YP_002503841.1 221230425 7325872 complement(2158251..2159072) 1 NC_011896.1 hypothetical protein 2159072 7325872 MLBr_01782 Mycobacterium leprae Br4923 hypothetical protein YP_002503841.1 2158251 R 561304 CDS YP_002503842.1 221230426 7325873 complement(2159072..2160040) 1 NC_011896.1 transcriptional regulator 2160040 7325873 MLBr_01783 Mycobacterium leprae Br4923 transcriptional regulator YP_002503842.1 2159072 R 561304 CDS YP_002503843.1 221230427 7325874 2160202..2161287 1 NC_011896.1 alcohol dehydrogenase 2161287 adhE2 7325874 adhE2 Mycobacterium leprae Br4923 alcohol dehydrogenase YP_002503843.1 2160202 D 561304 CDS YP_002503844.1 221230428 7325877 complement(2163282..2163746) 1 NC_011896.1 hypothetical protein 2163746 7325877 MLBr_01788 Mycobacterium leprae Br4923 hypothetical protein YP_002503844.1 2163282 R 561304 CDS YP_002503845.1 221230429 7325880 complement(2165547..2165990) 1 NC_011896.1 hypothetical protein 2165990 7325880 MLBr_01791 Mycobacterium leprae Br4923 hypothetical protein YP_002503845.1 2165547 R 561304 CDS YP_002503846.1 221230430 7327325 2168940..2169245 1 NC_011896.1 hypothetical protein 2169245 7327325 MLBr_01793 Mycobacterium leprae Br4923 hypothetical protein YP_002503846.1 2168940 D 561304 CDS YP_002503847.1 221230431 7325882 2171439..2172647 1 NC_011896.1 aminotransferase 2172647 7325882 MLBr_01794 Mycobacterium leprae Br4923 aminotransferase YP_002503847.1 2171439 D 561304 CDS YP_002503848.1 221230432 7325883 2174224..2174670 1 NC_011896.1 hypothetical protein 2174670 hsp18 7325883 hsp18 Mycobacterium leprae Br4923 hypothetical protein YP_002503848.1 2174224 D 561304 CDS YP_002503849.1 221230433 7324697 2175229..2175642 1 NC_011896.1 hypothetical protein 2175642 7324697 MLBr_01796 Mycobacterium leprae Br4923 hypothetical protein YP_002503849.1 2175229 D 561304 CDS YP_002503850.1 221230434 7325395 complement(2176846..2177829) 1 NC_011896.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2177829 7325395 MLBr_01798 Mycobacterium leprae Br4923 arginine/ornithine transport system ATPase YP_002503850.1 2176846 R 561304 CDS YP_002503851.1 221230435 7325885 complement(2177830..2180106) 1 NC_011896.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2180106 mutB 7325885 mutB Mycobacterium leprae Br4923 methylmalonyl-CoA mutase YP_002503851.1 2177830 R 561304 CDS YP_002503852.1 221230436 7324943 complement(2180112..2182022) 1 NC_011896.1 methylmalonyl-CoA mutase subunit beta 2182022 mutA 7324943 mutA Mycobacterium leprae Br4923 methylmalonyl-CoA mutase subunit beta YP_002503852.1 2180112 R 561304 CDS YP_002503853.1 221230437 7325886 complement(2183122..2184246) 1 NC_011896.1 hypothetical protein 2184246 7325886 MLBr_01802 Mycobacterium leprae Br4923 hypothetical protein YP_002503853.1 2183122 R 561304 CDS YP_002503854.1 221230438 7325887 complement(2184283..2184714) 1 NC_011896.1 hypothetical protein 2184714 7325887 MLBr_01803 Mycobacterium leprae Br4923 hypothetical protein YP_002503854.1 2184283 R 561304 CDS YP_002503855.1 221230439 7325888 2184772..2185668 1 NC_011896.1 hypothetical protein 2185668 7325888 MLBr_01804 Mycobacterium leprae Br4923 hypothetical protein YP_002503855.1 2184772 D 561304 CDS YP_002503856.1 221230440 7325889 complement(2185705..2186715) 1 NC_011896.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2186715 hemH 7325889 hemH Mycobacterium leprae Br4923 ferrochelatase YP_002503856.1 2185705 R 561304 CDS YP_002503857.1 221230441 7324677 complement(2186722..2187531) 1 NC_011896.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 2187531 inhA 7324677 inhA Mycobacterium leprae Br4923 enoyl-(acyl carrier protein) reductase YP_002503857.1 2186722 R 561304 CDS YP_002503858.1 221230442 7324720 complement(2187561..2188322) 1 NC_011896.1 3-oxoacyl-ACP reductase 2188322 fabG1 7324720 fabG1 Mycobacterium leprae Br4923 3-oxoacyl-ACP reductase YP_002503858.1 2187561 R 561304 CDS YP_002503859.1 221230443 7325233 complement(2188395..2189402) 1 NC_011896.1 hypothetical protein 2189402 7325233 MLBr_01808 Mycobacterium leprae Br4923 hypothetical protein YP_002503859.1 2188395 R 561304 CDS YP_002503860.1 221230444 7325890 complement(2189446..2190408) 1 NC_011896.1 hypothetical protein 2190408 7325890 MLBr_01809 Mycobacterium leprae Br4923 hypothetical protein YP_002503860.1 2189446 R 561304 CDS YP_002503861.1 221230445 7325891 complement(2190405..2191538) 1 NC_011896.1 MoxR 2191538 moxR 7325891 moxR Mycobacterium leprae Br4923 MoxR YP_002503861.1 2190405 R 561304 CDS YP_002503862.1 221230446 7324923 complement(2191773..2192498) 1 NC_011896.1 hypothetical protein 2192498 7324923 MLBr_01811 Mycobacterium leprae Br4923 hypothetical protein YP_002503862.1 2191773 R 561304 CDS YP_002503863.1 221230447 7325892 complement(2192525..2193964) 1 NC_011896.1 hypothetical protein 2193964 7325892 MLBr_01812 Mycobacterium leprae Br4923 hypothetical protein YP_002503863.1 2192525 R 561304 CDS YP_002503864.1 221230448 7325893 complement(2194204..2194776) 1 NC_011896.1 hypothetical protein 2194776 7325893 MLBr_01813 Mycobacterium leprae Br4923 hypothetical protein YP_002503864.1 2194204 R 561304 CDS YP_002503865.1 221230449 7325894 2195059..2197893 1 NC_011896.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2197893 acn 7325894 acn Mycobacterium leprae Br4923 aconitate hydratase YP_002503865.1 2195059 D 561304 CDS YP_002503866.1 221230450 7325895 complement(2198882..2200519) 1 NC_011896.1 ABC transporter ATP-binding protein 2200519 7325895 MLBr_01816 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503866.1 2198882 R 561304 CDS YP_002503867.1 221230451 7326191 complement(2201448..2201840) 1 NC_011896.1 thioredoxin 2201840 trxB 7326191 trxB Mycobacterium leprae Br4923 thioredoxin YP_002503867.1 2201448 R 561304 CDS YP_002503868.1 221230452 7325897 complement(2204653..2205006) 1 NC_011896.1 hypothetical protein 2205006 7325897 MLBr_01821 Mycobacterium leprae Br4923 hypothetical protein YP_002503868.1 2204653 R 561304 CDS YP_002503869.1 221230453 7326123 complement(2212373..2214091) 1 NC_011896.1 PPE family protein 2214091 PPE 7326123 PPE Mycobacterium leprae Br4923 PPE family protein YP_002503869.1 2212373 R 561304 CDS YP_002503870.1 221230454 7325903 2214738..2215115 1 NC_011896.1 hypothetical protein 2215115 7325903 MLBr_01829 Mycobacterium leprae Br4923 hypothetical protein YP_002503870.1 2214738 D 561304 CDS YP_002503871.1 221230455 7325905 complement(2219327..2220127) 1 NC_011896.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 2220127 mapA 7325905 mapA Mycobacterium leprae Br4923 methionine aminopeptidase YP_002503871.1 2219327 R 561304 CDS YP_002503872.1 221230456 7325436 complement(2220139..2220684) 1 NC_011896.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 2220684 adk 7325436 adk Mycobacterium leprae Br4923 adenylate kinase YP_002503872.1 2220139 R 561304 CDS YP_002503873.1 221230457 7327192 complement(2220681..2221997) 1 NC_011896.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2221997 secY 7327192 secY Mycobacterium leprae Br4923 preprotein translocase subunit SecY YP_002503873.1 2220681 R 561304 CDS YP_002503874.1 221230458 7325906 complement(2223141..2223824) 1 NC_011896.1 hypothetical protein 2223824 7325906 MLBr_01835 Mycobacterium leprae Br4923 hypothetical protein YP_002503874.1 2223141 R 561304 CDS YP_002503875.1 221230459 7325318 complement(2226861..2228669) 1 NC_011896.1 protease IV, signal peptide peptidase 2228669 sppA 7325318 sppA Mycobacterium leprae Br4923 protease IV, signal peptide peptidase YP_002503875.1 2226861 R 561304 CDS YP_002503876.1 221230460 7326000 complement(2228905..2229345) 1 NC_011896.1 late assembly protein; 50S ribosomal protein L15 2229345 rplO 7326000 rplO Mycobacterium leprae Br4923 50S ribosomal protein L15 YP_002503876.1 2228905 R 561304 CDS YP_002503877.1 221230461 7326653 complement(2229346..2229561) 1 NC_011896.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2229561 rpmD 7326653 rpmD Mycobacterium leprae Br4923 50S ribosomal protein L30 YP_002503877.1 2229346 R 561304 CDS YP_002503878.1 221230462 7326667 complement(2229564..2230217) 1 NC_011896.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2230217 rpsE 7326667 rpsE Mycobacterium leprae Br4923 30S ribosomal protein S5 YP_002503878.1 2229564 R 561304 CDS YP_002503879.1 221230463 7326681 complement(2230246..2230611) 1 NC_011896.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2230611 rplR 7326681 rplR Mycobacterium leprae Br4923 50S ribosomal protein L18 YP_002503879.1 2230246 R 561304 CDS YP_002503880.1 221230464 7326656 complement(2230617..2231156) 1 NC_011896.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2231156 rplF 7326656 rplF Mycobacterium leprae Br4923 50S ribosomal protein L6 YP_002503880.1 2230617 R 561304 CDS YP_002503881.1 221230465 7326646 complement(2231182..2231580) 1 NC_011896.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2231580 rpsH 7326646 rpsH Mycobacterium leprae Br4923 30S ribosomal protein S8 YP_002503881.1 2231182 R 561304 CDS YP_002503882.1 221230466 7325948 complement(2231663..2231848) 1 NC_011896.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 2231848 rpsN 7325948 rpsN Mycobacterium leprae Br4923 30S ribosomal protein S14 YP_002503882.1 2231663 R 561304 CDS YP_002503883.1 221230467 7325954 complement(2231854..2232417) 1 NC_011896.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2232417 rplE 7325954 rplE Mycobacterium leprae Br4923 50S ribosomal protein L5 YP_002503883.1 2231854 R 561304 CDS YP_002503884.1 221230468 7326645 complement(2232418..2232735) 1 NC_011896.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2232735 rplX 7326645 rplX Mycobacterium leprae Br4923 50S ribosomal protein L24 YP_002503884.1 2232418 R 561304 CDS YP_002503885.1 221230469 7326662 complement(2232736..2233077) 1 NC_011896.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 2233077 rplN 7326662 rplN Mycobacterium leprae Br4923 50S ribosomal protein L14 YP_002503885.1 2232736 R 561304 CDS YP_002503886.1 221230470 7327253 complement(2238274..2238657) 1 NC_011896.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2238657 rpsQ 7327253 rpsQ Mycobacterium leprae Br4923 30S ribosomal protein S17 YP_002503886.1 2238274 R 561304 CDS YP_002503887.1 221230471 7325957 complement(2238654..2238899) 1 NC_011896.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2238899 rpmC 7325957 rpmC Mycobacterium leprae Br4923 50S ribosomal protein L29 YP_002503887.1 2238654 R 561304 CDS YP_002503888.1 221230472 7326666 complement(2238896..2239312) 1 NC_011896.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2239312 rplP 7326666 rplP Mycobacterium leprae Br4923 50S ribosomal protein L16 YP_002503888.1 2238896 R 561304 CDS YP_002503889.1 221230473 7326654 complement(2239316..2240161) 1 NC_011896.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2240161 rpsC 7326654 rpsC Mycobacterium leprae Br4923 30S ribosomal protein S3 YP_002503889.1 2239316 R 561304 CDS YP_002503890.1 221230474 7326679 complement(2240161..2240688) 1 NC_011896.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2240688 rplV 7326679 rplV Mycobacterium leprae Br4923 50S ribosomal protein L22 YP_002503890.1 2240161 R 561304 CDS YP_002503891.1 221230475 7326660 complement(2240685..2240966) 1 NC_011896.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 2240966 rpsS 7326660 rpsS Mycobacterium leprae Br4923 30S ribosomal protein S19 YP_002503891.1 2240685 R 561304 CDS YP_002503892.1 221230476 7325959 complement(2240990..2241832) 1 NC_011896.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 2241832 rplB 7325959 rplB Mycobacterium leprae Br4923 50S ribosomal protein L2 YP_002503892.1 2240990 R 561304 CDS YP_002503893.1 221230477 7326642 complement(2241862..2242164) 1 NC_011896.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 2242164 rplW 7326642 rplW Mycobacterium leprae Br4923 50S ribosomal protein L23 YP_002503893.1 2241862 R 561304 CDS YP_002503894.1 221230478 7326661 complement(2242164..2242856) 1 NC_011896.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 2242856 rplD 7326661 rplD Mycobacterium leprae Br4923 50S ribosomal protein L4 YP_002503894.1 2242164 R 561304 CDS YP_002503895.1 221230479 7326644 complement(2242856..2243512) 1 NC_011896.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 2243512 rplC 7326644 rplC Mycobacterium leprae Br4923 50S ribosomal protein L3 YP_002503895.1 2242856 R 561304 CDS YP_002503896.1 221230480 7326643 complement(2243525..2243830) 1 NC_011896.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 2243830 rpsJ 7326643 rpsJ Mycobacterium leprae Br4923 30S ribosomal protein S10 YP_002503896.1 2243525 R 561304 CDS YP_002503897.1 221230481 7325921 complement(2255715..2256905) 1 NC_011896.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 2256905 tuf 7325921 tuf Mycobacterium leprae Br4923 elongation factor Tu YP_002503897.1 2255715 R 561304 CDS YP_002503898.1 221230482 7327293 complement(2257014..2259119) 1 NC_011896.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 2259119 fusA 7327293 fusA Mycobacterium leprae Br4923 elongation factor G YP_002503898.1 2257014 R 561304 CDS YP_002503899.1 221230483 7325322 complement(2259213..2259683) 1 NC_011896.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 2259683 rpsG 7325322 rpsG Mycobacterium leprae Br4923 30S ribosomal protein S7 YP_002503899.1 2259213 R 561304 CDS YP_002503900.1 221230484 7326683 complement(2259683..2260057) 1 NC_011896.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 2260057 rpsL 7326683 rpsL Mycobacterium leprae Br4923 30S ribosomal protein S12 YP_002503900.1 2259683 R 561304 CDS YP_002503901.1 221230485 7325283 complement(2268112..2268870) 1 NC_011896.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2268870 7325283 MLBr_01889 Mycobacterium leprae Br4923 endonuclease IV YP_002503901.1 2268112 R 561304 CDS YP_002503902.1 221230486 7325927 complement(2269195..2273145) 1 NC_011896.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 2273145 rpoC 7325927 rpoC Mycobacterium leprae Br4923 DNA-directed RNA polymerase subunit beta' YP_002503902.1 2269195 R 561304 CDS YP_002503903.1 221230487 7326675 complement(2273194..2276730) 1 NC_011896.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 2276730 rpoB 7326675 rpoB Mycobacterium leprae Br4923 DNA-directed RNA polymerase subunit beta YP_002503903.1 2273194 R 561304 CDS YP_002503904.1 221230488 7326674 complement(2277185..2278201) 1 NC_011896.1 ABC transporter ATP-binding protein 2278201 7326674 MLBr_01892 Mycobacterium leprae Br4923 ABC transporter ATP-binding protein YP_002503904.1 2277185 R 561304 CDS YP_002503905.1 221230489 7325930 complement(2280360..2280752) 1 NC_011896.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 2280752 rplL 7325930 rplL Mycobacterium leprae Br4923 50S ribosomal protein L7/L12 YP_002503905.1 2280360 R 561304 CDS YP_002503906.1 221230490 7326650 complement(2280788..2281321) 1 NC_011896.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 2281321 rplJ 7326650 rplJ Mycobacterium leprae Br4923 50S ribosomal protein L10 YP_002503906.1 2280788 R 561304 CDS YP_002503907.1 221230491 7325931 2282213..2283559 1 NC_011896.1 hypothetical protein 2283559 7325931 MLBr_01898 Mycobacterium leprae Br4923 hypothetical protein YP_002503907.1 2282213 D 561304 CDS YP_002503908.1 221230492 7325932 2283559..2284473 1 NC_011896.1 hydrolase 2284473 lipG 7325932 lipG Mycobacterium leprae Br4923 hydrolase YP_002503908.1 2283559 D 561304 CDS YP_002503909.1 221230493 7325391 2284531..2285391 1 NC_011896.1 methyl mycolic acid synthase 1 2285391 mmaA1 7325391 mmaA1 Mycobacterium leprae Br4923 methyl mycolic acid synthase 1 YP_002503909.1 2284531 D 561304 CDS YP_002503910.1 221230494 7325934 2287556..2288452 1 NC_011896.1 methyl mycolic acid synthase 4 2288452 mmaA4 7325934 mmaA4 Mycobacterium leprae Br4923 methyl mycolic acid synthase 4 YP_002503910.1 2287556 D 561304 CDS YP_002503911.1 221230495 7324904 complement(2290234..2290941) 1 NC_011896.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 2290941 rplA 7324904 rplA Mycobacterium leprae Br4923 50S ribosomal protein L1 YP_002503911.1 2290234 R 561304 CDS YP_002503912.1 221230496 7326641 complement(2291073..2291501) 1 NC_011896.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 2291501 rplK 7326641 rplK Mycobacterium leprae Br4923 50S ribosomal protein L11 YP_002503912.1 2291073 R 561304 CDS YP_002503913.1 221230497 7326649 complement(2291529..2292215) 1 NC_011896.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 2292215 nusG 7326649 nusG Mycobacterium leprae Br4923 transcription antitermination protein NusG YP_002503913.1 2291529 R 561304 CDS YP_002503914.1 221230498 7327336 complement(2292293..2292733) 1 NC_011896.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 2292733 secE 7327336 secE Mycobacterium leprae Br4923 preprotein translocase subunit SecE YP_002503914.1 2292293 R 561304 CDS YP_002503915.1 221230499 7327286 complement(2293069..2293569) 1 NC_011896.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 2293569 7327286 MLBr_01908 Mycobacterium leprae Br4923 (3R)-hydroxyacyl-ACP dehydratase subunit HadC YP_002503915.1 2293069 R 561304 CDS YP_002503916.1 221230500 7325935 complement(2293573..2294001) 1 NC_011896.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 2294001 7325935 MLBr_01909 Mycobacterium leprae Br4923 (3R)-hydroxyacyl-ACP dehydratase subunit HadB YP_002503916.1 2293573 R 561304 CDS YP_002503917.1 221230501 7325936 complement(2293988..2294467) 1 NC_011896.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 2294467 7325936 MLBr_01910 Mycobacterium leprae Br4923 (3R)-hydroxyacyl-ACP dehydratase subunit HadA YP_002503917.1 2293988 R 561304 CDS YP_002503918.1 221230502 7325937 complement(2294514..2294681) 1 NC_011896.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 2294681 rpmG 7325937 rpmG Mycobacterium leprae Br4923 50S ribosomal protein L33 YP_002503918.1 2294514 R 561304 CDS YP_002503919.1 221230503 7326022 complement(2295081..2295296) 1 NC_011896.1 hypothetical protein 2295296 7326022 MLBr_01911A Mycobacterium leprae Br4923 hypothetical protein YP_002503919.1 2295081 R 561304 CDS YP_002503920.1 221230504 7325938 2295449..2296165 1 NC_011896.1 glyoxylase 2296165 7325938 MLBr_01912 Mycobacterium leprae Br4923 glyoxylase YP_002503920.1 2295449 D 561304 CDS YP_002503921.1 221230505 7325420 2298396..2298740 1 NC_011896.1 hypothetical protein 2298740 7325420 MLBr_01915 Mycobacterium leprae Br4923 hypothetical protein YP_002503921.1 2298396 D 561304 CDS YP_002503922.1 221230506 7325942 complement(2301760..2302551) 1 NC_011896.1 hypothetical protein 2302551 7325942 MLBr_01918 Mycobacterium leprae Br4923 hypothetical protein YP_002503922.1 2301760 R 561304 CDS YP_002503923.1 221230507 7325943 complement(2302690..2303331) 1 NC_011896.1 carbonic anhydrase 2303331 7325943 MLBr_01919 Mycobacterium leprae Br4923 carbonic anhydrase YP_002503923.1 2302690 R 561304 CDS YP_002503924.1 221230508 7325944 2303330..2304223 1 NC_011896.1 DNA glycosylase 2304223 mutY 7325944 mutY Mycobacterium leprae Br4923 DNA glycosylase YP_002503924.1 2303330 D 561304 CDS YP_002503925.1 221230509 7324946 complement(2304232..2305002) 1 NC_011896.1 hypothetical protein 2305002 7324946 MLBr_01921 Mycobacterium leprae Br4923 hypothetical protein YP_002503925.1 2304232 R 561304 CDS YP_002503926.1 221230510 7325945 2305128..2305445 1 NC_011896.1 hypothetical protein 2305445 7325945 MLBr_01922 Mycobacterium leprae Br4923 hypothetical protein YP_002503926.1 2305128 D 561304 CDS YP_002503927.1 221230511 7325946 2305420..2306784 1 NC_011896.1 hypothetical protein 2306784 lpqF 7325946 lpqF Mycobacterium leprae Br4923 hypothetical protein YP_002503927.1 2305420 D 561304 CDS YP_002503928.1 221230512 7325947 complement(2310696..2311418) 1 NC_011896.1 superoxide dismutase (Cu-Zn) 2311418 sodC 7325947 sodC Mycobacterium leprae Br4923 superoxide dismutase (Cu-Zn) YP_002503928.1 2310696 R 561304 CDS YP_002503929.1 221230513 7325998 complement(2311483..>2311986) 1 NC_011896.1 tuberculin related peptide >2311986 7325998 MLBr_01926 Mycobacterium leprae Br4923 tuberculin related peptide YP_002503929.1 2311483 R 561304 CDS YP_002503930.1 221230514 7325541 complement(2312017..2312325) 1 NC_011896.1 hypothetical protein 2312325 7325541 MLBr_01927 Mycobacterium leprae Br4923 hypothetical protein YP_002503930.1 2312017 R 561304 CDS YP_002503931.1 221230515 7325542 complement(2312356..2312493) 1 NC_011896.1 hypothetical protein 2312493 7325542 MLBr_01928 Mycobacterium leprae Br4923 hypothetical protein YP_002503931.1 2312356 R 561304 CDS YP_002503932.1 221230516 7325543 2312540..2313133 1 NC_011896.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2313133 def 7325543 def Mycobacterium leprae Br4923 peptide deformylase YP_002503932.1 2312540 D 561304 CDS YP_002503933.1 221230517 7327323 2314746..2315159 1 NC_011896.1 hypothetical protein 2315159 7327323 MLBr_01932 Mycobacterium leprae Br4923 hypothetical protein YP_002503933.1 2314746 D 561304 CDS YP_002503934.1 221230518 7324994 complement(2322124..2323194) 1 NC_011896.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 2323194 7324994 MLBr_01936 Mycobacterium leprae Br4923 GTP-dependent nucleic acid-binding protein EngD YP_002503934.1 2322124 R 561304 CDS YP_002503935.1 221230519 7325547 2323245..2324477 1 NC_011896.1 integral membrane protein 2324477 7325547 MLBr_01937 Mycobacterium leprae Br4923 integral membrane protein YP_002503935.1 2323245 D 561304 CDS YP_002503936.1 221230520 7325548 complement(2324488..2325495) 1 NC_011896.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2325495 ispH 7325548 ispH Mycobacterium leprae Br4923 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002503936.1 2324488 R 561304 CDS YP_002503937.1 221230521 7325434 2325664..2326281 1 NC_011896.1 hypothetical protein 2326281 7325434 MLBr_01939 Mycobacterium leprae Br4923 hypothetical protein YP_002503937.1 2325664 D 561304 CDS YP_002503938.1 221230522 7325549 2326278..2327564 1 NC_011896.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2327564 xseA 7325549 xseA Mycobacterium leprae Br4923 exodeoxyribonuclease VII large subunit YP_002503938.1 2326278 D 561304 CDS YP_002503939.1 221230523 7327321 2327554..2327817 1 NC_011896.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2327817 xseB 7327321 xseB Mycobacterium leprae Br4923 exodeoxyribonuclease VII small subunit YP_002503939.1 2327554 D 561304 CDS YP_002503940.1 221230524 7327322 2327868..2328998 1 NC_011896.1 cholesterol dehydrogenase 2328998 7327322 MLBr_01942 Mycobacterium leprae Br4923 cholesterol dehydrogenase YP_002503940.1 2327868 D 561304 CDS YP_002503941.1 221230525 7325552 complement(2331701..2332474) 1 NC_011896.1 hypothetical protein 2332474 7325552 MLBr_01945 Mycobacterium leprae Br4923 hypothetical protein YP_002503941.1 2331701 R 561304 CDS YP_002503942.1 221230526 7325553 2332554..2333540 1 NC_011896.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 2333540 glpX 7325553 glpX Mycobacterium leprae Br4923 fructose 1,6-bisphosphatase II YP_002503942.1 2332554 D 561304 CDS YP_002503943.1 221230527 7325554 2333549..2334973 1 NC_011896.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2334973 fumC 7325554 fumC Mycobacterium leprae Br4923 fumarate hydratase YP_002503943.1 2333549 D 561304 CDS YP_002503944.1 221230528 7325555 complement(2336202..2336561) 1 NC_011896.1 hypothetical protein 2336561 7325555 MLBr_01949 Mycobacterium leprae Br4923 hypothetical protein YP_002503944.1 2336202 R 561304 CDS YP_002503945.1 221230529 7325556 complement(2336614..2337489) 1 NC_011896.1 carbohydrate degrading enzyme 2337489 7325556 MLBr_01950 Mycobacterium leprae Br4923 carbohydrate degrading enzyme YP_002503945.1 2336614 R 561304 CDS YP_002503946.1 221230530 7325557 complement(2337544..2338845) 1 NC_011896.1 PhoH-like protein 2338845 phoH2 7325557 phoH2 Mycobacterium leprae Br4923 PhoH-like protein YP_002503946.1 2337544 R 561304 CDS YP_002503947.1 221230531 7327393 complement(2339195..2340022) 1 NC_011896.1 acyl-[ACP] desaturase 2340022 desA2 7327393 desA2 Mycobacterium leprae Br4923 acyl-[ACP] desaturase YP_002503947.1 2339195 R 561304 CDS YP_002503948.1 221230532 7326168 complement(2340079..2341359) 1 NC_011896.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2341359 glyA 7326168 glyA Mycobacterium leprae Br4923 serine hydroxymethyltransferase YP_002503948.1 2340079 R 561304 CDS YP_002503949.1 221230533 7325371 2341488..2342426 1 NC_011896.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 2342426 coaA 7325371 coaA Mycobacterium leprae Br4923 pantothenate kinase YP_002503949.1 2341488 D 561304 CDS YP_002503950.1 221230534 7326114 complement(2343254..2344003) 1 NC_011896.1 pseudouridylate synthase 2344003 truA 7326114 truA Mycobacterium leprae Br4923 pseudouridylate synthase YP_002503950.1 2343254 R 561304 CDS YP_002503951.1 221230535 7327287 complement(2344095..2344607) 1 NC_011896.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 2344607 rplQ 7327287 rplQ Mycobacterium leprae Br4923 50S ribosomal protein L17 YP_002503951.1 2344095 R 561304 CDS YP_002503952.1 221230536 7326655 complement(2344631..2345674) 1 NC_011896.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2345674 rpoA 7326655 rpoA Mycobacterium leprae Br4923 DNA-directed RNA polymerase subunit alpha YP_002503952.1 2344631 R 561304 CDS YP_002503953.1 221230537 7326673 complement(2345759..2346364) 1 NC_011896.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 2346364 rpsD 7326673 rpsD Mycobacterium leprae Br4923 30S ribosomal protein S4 YP_002503953.1 2345759 R 561304 CDS YP_002503954.1 221230538 7326680 complement(2346398..2346814) 1 NC_011896.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2346814 rpsK 7326680 rpsK Mycobacterium leprae Br4923 30S ribosomal protein S11 YP_002503954.1 2346398 R 561304 CDS YP_002503955.1 221230539 7325951 complement(2346818..2347192) 1 NC_011896.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2347192 rpsM 7325951 rpsM Mycobacterium leprae Br4923 30S ribosomal protein S13 YP_002503955.1 2346818 R 561304 CDS YP_002503956.1 221230540 7325953 complement(2347369..2347482) 1 NC_011896.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2347482 rpmJ 7325953 rpmJ Mycobacterium leprae Br4923 50S ribosomal protein L36 YP_002503956.1 2347369 R 561304 CDS YP_002503957.1 221230541 7326672 complement(2347522..2347743) 1 NC_011896.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2347743 infA 7326672 infA Mycobacterium leprae Br4923 translation initiation factor IF-1 YP_002503957.1 2347522 R 561304 CDS YP_002503958.1 221230542 7325558 2348258..2349259 1 NC_011896.1 dTDP-glucose 4,6-dehydratase 2349259 rmlB 7325558 rmlB Mycobacterium leprae Br4923 dTDP-glucose 4,6-dehydratase YP_002503958.1 2348258 D 561304 CDS YP_002503959.1 221230543 7326628 2349261..2349869 1 NC_011896.1 dTDP-4-dehydrorhamnose 3,5-epimerase 2349869 rmlC 7326628 rmlC Mycobacterium leprae Br4923 dTDP-4-dehydrorhamnose 3,5-epimerase YP_002503959.1 2349261 D 561304 CDS YP_002503960.1 221230544 7326630 2349914..2350399 1 NC_011896.1 lipoprotein 2350399 lpqH 7326630 lpqH Mycobacterium leprae Br4923 lipoprotein YP_002503960.1 2349914 D 561304 CDS YP_002503961.1 221230545 7325563 complement(2356236..2356466) 1 NC_011896.1 hypothetical protein 2356466 7325563 MLBr_01972 Mycobacterium leprae Br4923 hypothetical protein YP_002503961.1 2356236 R 561304 CDS YP_002503962.1 221230546 7325565 2358377..2360095 1 NC_011896.1 permease 2360095 7325565 MLBr_01974 Mycobacterium leprae Br4923 permease YP_002503962.1 2358377 D 561304 CDS YP_002503963.1 221230547 7325567 complement(2361144..2361491) 1 NC_011896.1 hypothetical protein 2361491 7325567 MLBr_01976 Mycobacterium leprae Br4923 hypothetical protein YP_002503963.1 2361144 R 561304 CDS YP_002503964.1 221230548 7325230 complement(2363859..2364266) 1 NC_011896.1 hypothetical protein 2364266 7325230 MLBr_01979 Mycobacterium leprae Br4923 hypothetical protein YP_002503964.1 2363859 R 561304 CDS YP_002503965.1 221230549 7325571 2366522..2366830 1 NC_011896.1 integral membrane protein 2366830 7325571 MLBr_01982 Mycobacterium leprae Br4923 integral membrane protein YP_002503965.1 2366522 D 561304 CDS YP_002503966.1 221230550 7325572 2367343..2367810 1 NC_011896.1 hypothetical protein 2367810 7325572 MLBr_01983 Mycobacterium leprae Br4923 hypothetical protein YP_002503966.1 2367343 D 561304 CDS YP_002503967.1 221230551 7325574 complement(2369727..2372123) 1 NC_011896.1 isocitrate lyase 2372123 aceA 7325574 aceA Mycobacterium leprae Br4923 isocitrate lyase YP_002503967.1 2369727 R 561304 CDS YP_002503968.1 221230552 7325575 2373352..2375652 1 NC_011896.1 cation-transporting ATPase 2375652 ctpA 7325575 ctpA Mycobacterium leprae Br4923 cation-transporting ATPase YP_002503968.1 2373352 D 561304 CDS YP_002503969.1 221230553 7326136 complement(2375630..2376343) 1 NC_011896.1 integral membrane protein 2376343 7326136 MLBr_01988 Mycobacterium leprae Br4923 integral membrane protein YP_002503969.1 2375630 R 561304 CDS YP_002503970.1 221230554 7325576 complement(2376660..2377010) 1 NC_011896.1 hypothetical protein 2377010 7325576 MLBr_01989 Mycobacterium leprae Br4923 hypothetical protein YP_002503970.1 2376660 R 561304 CDS YP_002503971.1 221230555 7325577 complement(2377090..2377332) 1 NC_011896.1 integral membrane protein 2377332 7325577 MLBr_01990 Mycobacterium leprae Br4923 integral membrane protein YP_002503971.1 2377090 R 561304 CDS YP_002503972.1 221230556 7325578 2378419..2379825 1 NC_011896.1 PPE family protein 2379825 PPE 7325578 PPE Mycobacterium leprae Br4923 PPE family protein YP_002503972.1 2378419 D 561304 CDS YP_002503973.1 221230557 7324995 2379974..2380843 1 NC_011896.1 oxidoreductase 2380843 7324995 MLBr_01992 Mycobacterium leprae Br4923 oxidoreductase YP_002503973.1 2379974 D 561304 CDS YP_002503974.1 221230558 7325579 2380840..2381391 1 NC_011896.1 hypothetical protein 2381391 7325579 MLBr_01993 Mycobacterium leprae Br4923 hypothetical protein YP_002503974.1 2380840 D 561304 CDS YP_002503975.1 221230559 7325580 2381421..2383019 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2383019 fadD10 7325580 fadD10 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002503975.1 2381421 D 561304 CDS YP_002503976.1 221230560 7325244 2383012..2383248 1 NC_011896.1 hypothetical protein 2383248 7325244 MLBr_01995 Mycobacterium leprae Br4923 hypothetical protein YP_002503976.1 2383012 D 561304 CDS YP_002503977.1 221230561 7325581 2383245..2387450 1 NC_011896.1 peptide synthase 2387450 nrp 7325581 nrp Mycobacterium leprae Br4923 peptide synthase YP_002503977.1 2383245 D 561304 CDS YP_002503978.1 221230562 7324968 complement(2387457..2388089) 1 NC_011896.1 integral membrane protein 2388089 7324968 MLBr_01997 Mycobacterium leprae Br4923 integral membrane protein YP_002503978.1 2387457 R 561304 CDS YP_002503979.1 221230563 7325582 2388202..2390181 1 NC_011896.1 hypothetical protein 2390181 7325582 MLBr_01998 Mycobacterium leprae Br4923 hypothetical protein YP_002503979.1 2388202 D 561304 CDS YP_002503980.1 221230564 7325584 complement(2391242..2393494) 1 NC_011896.1 cation-transporting ATPase 2393494 ctpB 7325584 ctpB Mycobacterium leprae Br4923 cation-transporting ATPase YP_002503980.1 2391242 R 561304 CDS YP_002503981.1 221230565 7324724 2402898..2403359 1 NC_011896.1 lipoprotein 2403359 7324724 MLBr_02010 Mycobacterium leprae Br4923 lipoprotein YP_002503981.1 2402898 D 561304 CDS YP_002503982.1 221230566 7325591 2403414..2404376 1 NC_011896.1 D-amino acid oxidase 2404376 aao 7325591 aao Mycobacterium leprae Br4923 D-amino acid oxidase YP_002503982.1 2403414 D 561304 CDS YP_002503983.1 221230567 7327173 complement(2404394..2404813) 1 NC_011896.1 hypothetical protein 2404813 7327173 MLBr_02012 Mycobacterium leprae Br4923 hypothetical protein YP_002503983.1 2404394 R 561304 CDS YP_002503984.1 221230568 7325592 complement(2405281..2405661) 1 NC_011896.1 hypothetical protein 2405661 7325592 MLBr_02013 Mycobacterium leprae Br4923 hypothetical protein YP_002503984.1 2405281 R 561304 CDS YP_002503985.1 221230569 7324951 complement(2407225..2408523) 1 NC_011896.1 competence damage-inducible protein A 2408523 cinA 7324951 cinA Mycobacterium leprae Br4923 competence damage-inducible protein A YP_002503985.1 2407225 R 561304 CDS YP_002503986.1 221230570 7325595 2411240..2412154 1 NC_011896.1 hypothetical protein 2412154 7325595 MLBr_02020 Mycobacterium leprae Br4923 hypothetical protein YP_002503986.1 2411240 D 561304 CDS YP_002503987.1 221230571 7325597 complement(2413569..2414093) 1 NC_011896.1 hypothetical protein 2414093 7325597 MLBr_02022 Mycobacterium leprae Br4923 hypothetical protein YP_002503987.1 2413569 R 561304 CDS YP_002503988.1 221230572 7325598 complement(2414189..2414593) 1 NC_011896.1 hypothetical protein 2414593 7325598 MLBr_02023 Mycobacterium leprae Br4923 hypothetical protein YP_002503988.1 2414189 R 561304 CDS YP_002503989.1 221230573 7325603 2418545..2419528 1 NC_011896.1 antigen 85A, mycolyltransferase 2419528 fbpB 7325603 fbpB Mycobacterium leprae Br4923 antigen 85A, mycolyltransferase YP_002503989.1 2418545 D 561304 CDS YP_002503990.1 221230574 7325604 2420572..2421045 1 NC_011896.1 hypothetical protein 2421045 7325604 MLBr_02030 Mycobacterium leprae Br4923 hypothetical protein YP_002503990.1 2420572 D 561304 CDS YP_002503991.1 221230575 7325605 2421076..2421531 1 NC_011896.1 hypothetical protein 2421531 7325605 MLBr_02031 Mycobacterium leprae Br4923 hypothetical protein YP_002503991.1 2421076 D 561304 CDS YP_002503992.1 221230576 7325608 complement(2425091..2425354) 1 NC_011896.1 hypothetical protein 2425354 7325608 MLBr_02035 Mycobacterium leprae Br4923 hypothetical protein YP_002503992.1 2425091 R 561304 CDS YP_002503993.1 221230577 7325351 complement(2429248..2429727) 1 NC_011896.1 bacterioferritin 2429727 bfrA 7325351 bfrA Mycobacterium leprae Br4923 bacterioferritin YP_002503993.1 2429248 R 561304 CDS YP_002503994.1 221230578 7325612 complement(2431909..2432844) 1 NC_011896.1 LysR family transcriptional regulator 2432844 oxyR 7325612 oxyR Mycobacterium leprae Br4923 LysR family transcriptional regulator YP_002503994.1 2431909 R 561304 CDS YP_002503995.1 221230579 7327343 2432954..2433541 1 NC_011896.1 alkyl hydroperoxide reductase 2433541 ahpC 7327343 ahpC Mycobacterium leprae Br4923 alkyl hydroperoxide reductase YP_002503995.1 2432954 D 561304 CDS YP_002503996.1 221230580 7327196 complement(2434293..2434514) 1 NC_011896.1 hypothetical protein 2434514 7327196 MLBr_02044 Mycobacterium leprae Br4923 hypothetical protein YP_002503996.1 2434293 R 561304 CDS YP_002503997.1 221230581 7325613 2434923..2435180 1 NC_011896.1 hypothetical protein 2435180 7325613 MLBr_02045 Mycobacterium leprae Br4923 hypothetical protein YP_002503997.1 2434923 D 561304 CDS YP_002503998.1 221230582 7325614 2435484..2436728 1 NC_011896.1 L-lactate dehydrogenase 2436728 lldD2 7325614 lldD2 Mycobacterium leprae Br4923 L-lactate dehydrogenase YP_002503998.1 2435484 D 561304 CDS YP_002503999.1 221230583 7325615 2437730..2437987 1 NC_011896.1 hypothetical protein 2437987 7325615 MLBr_02048 Mycobacterium leprae Br4923 hypothetical protein YP_002503999.1 2437730 D 561304 CDS YP_002504000.1 221230584 7325620 complement(2441022..2442029) 1 NC_011896.1 alcohol dehydrogenase 2442029 7325620 MLBr_02053 Mycobacterium leprae Br4923 alcohol dehydrogenase YP_002504000.1 2441022 R 561304 CDS YP_002504001.1 221230585 7325621 complement(2442107..2442406) 1 NC_011896.1 hypothetical protein 2442406 7325621 MLBr_02054 Mycobacterium leprae Br4923 hypothetical protein YP_002504001.1 2442107 R 561304 CDS YP_002504002.1 221230586 7325131 complement(2442566..2443429) 1 NC_011896.1 cell surface protein (associated with virulence) 2443429 modD 7325131 modD Mycobacterium leprae Br4923 cell surface protein (associated with virulence) YP_002504002.1 2442566 R 561304 CDS YP_002504003.1 221230587 7324916 2446481..2447155 1 NC_011896.1 short chain dehydrogenase 2447155 7324916 MLBr_02059 Mycobacterium leprae Br4923 short chain dehydrogenase YP_002504003.1 2446481 D 561304 CDS YP_002504004.1 221230588 7325133 2448347..2449747 1 NC_011896.1 dehydrogenase 2449747 7325133 MLBr_02061 Mycobacterium leprae Br4923 dehydrogenase YP_002504004.1 2448347 D 561304 CDS YP_002504005.1 221230589 7325135 2450581..2451009 1 NC_011896.1 regulator 2451009 7325135 MLBr_02063 Mycobacterium leprae Br4923 regulator YP_002504005.1 2450581 D 561304 CDS YP_002504006.1 221230590 7325136 2451014..2451964 1 NC_011896.1 hypothetical protein 2451964 7325136 MLBr_02064 Mycobacterium leprae Br4923 hypothetical protein YP_002504006.1 2451014 D 561304 CDS YP_002504007.1 221230591 7325137 2452104..2453555 1 NC_011896.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2453555 gnd 7325137 gnd Mycobacterium leprae Br4923 6-phosphogluconate dehydrogenase YP_002504007.1 2452104 D 561304 CDS YP_002504008.1 221230592 7324651 2453625..2455061 1 NC_011896.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2455061 guaB1 7324651 guaB1 Mycobacterium leprae Br4923 inosine 5-monophosphate dehydrogenase YP_002504008.1 2453625 D 561304 CDS YP_002504009.1 221230593 7325139 2457921..2460116 1 NC_011896.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2460116 glcB 7325139 glcB Mycobacterium leprae Br4923 malate synthase G YP_002504009.1 2457921 D 561304 CDS YP_002504010.1 221230594 7325342 2460242..2462443 1 NC_011896.1 hypothetical protein 2462443 7325342 MLBr_02070 Mycobacterium leprae Br4923 hypothetical protein YP_002504010.1 2460242 D 561304 CDS YP_002504011.1 221230595 7325141 complement(2463344..2466202) 1 NC_011896.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2466202 gcvB 7325141 gcvB Mycobacterium leprae Br4923 glycine dehydrogenase YP_002504011.1 2463344 R 561304 CDS YP_002504012.1 221230596 7325336 complement(2466370..2467065) 1 NC_011896.1 hypothetical protein 2467065 7325336 MLBr_02073 Mycobacterium leprae Br4923 hypothetical protein YP_002504012.1 2466370 R 561304 CDS YP_002504013.1 221230597 7325142 complement(2467298..2467792) 1 NC_011896.1 hypothetical protein 2467792 7325142 MLBr_02074 Mycobacterium leprae Br4923 hypothetical protein YP_002504013.1 2467298 R 561304 CDS YP_002504014.1 221230598 7325143 complement(2467909..2468664) 1 NC_011896.1 hypothetical protein 2468664 7325143 MLBr_02075 Mycobacterium leprae Br4923 hypothetical protein YP_002504014.1 2467909 R 561304 CDS YP_002504015.1 221230599 7325144 complement(2468661..2469149) 1 NC_011896.1 hypothetical protein 2469149 7325144 MLBr_02076 Mycobacterium leprae Br4923 hypothetical protein YP_002504015.1 2468661 R 561304 CDS YP_002504016.1 221230600 7325145 complement(2469393..2469791) 1 NC_011896.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2469791 gcvH 7325145 gcvH Mycobacterium leprae Br4923 glycine cleavage system protein H YP_002504016.1 2469393 R 561304 CDS YP_002504017.1 221230601 7325148 complement(2472012..2472632) 1 NC_011896.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2472632 pgsA2 7325148 pgsA2 Mycobacterium leprae Br4923 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002504017.1 2472012 R 561304 CDS YP_002504018.1 221230602 7327387 complement(2472694..2475030) 1 NC_011896.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2475030 secA2 7327387 secA2 Mycobacterium leprae Br4923 preprotein translocase subunit SecA YP_002504018.1 2472694 R 561304 CDS YP_002504019.1 221230603 7325974 complement(2475138..2476784) 1 NC_011896.1 hypothetical protein 2476784 ilvG 7325974 ilvG Mycobacterium leprae Br4923 hypothetical protein YP_002504019.1 2475138 R 561304 CDS YP_002504020.1 221230604 7324713 2476878..2478794 1 NC_011896.1 multidrug resistance pump 2478794 7324713 MLBr_02084 Mycobacterium leprae Br4923 multidrug resistance pump YP_002504020.1 2476878 D 561304 CDS YP_002504021.1 221230605 7325152 complement(2481469..2482773) 1 NC_011896.1 cytochrome p450 2482773 7325152 MLBr_02088 Mycobacterium leprae Br4923 cytochrome p450 YP_002504021.1 2481469 R 561304 CDS YP_002504022.1 221230606 7325155 2487634..2487819 1 NC_011896.1 hypothetical protein 2487819 7325155 MLBr_02091 Mycobacterium leprae Br4923 hypothetical protein YP_002504022.1 2487634 D 561304 CDS YP_002504023.1 221230607 7325157 complement(2489056..2489970) 1 NC_011896.1 membrane-bound component of phosphate transport 2489970 pstA1 7325157 pstA1 Mycobacterium leprae Br4923 membrane-bound component of phosphate transport YP_002504023.1 2489056 R 561304 CDS YP_002504024.1 221230608 7325020 complement(2489988..2490947) 1 NC_011896.1 membrane-bound component of phosphate transport 2490947 pstC2 7325020 pstC2 Mycobacterium leprae Br4923 membrane-bound component of phosphate transport YP_002504024.1 2489988 R 561304 CDS YP_002504025.1 221230609 7325025 complement(2490990..2492099) 1 NC_011896.1 PstS component of phosphate uptake 2492099 phoS2 7325025 phoS2 Mycobacterium leprae Br4923 PstS component of phosphate uptake YP_002504025.1 2490990 R 561304 CDS YP_002504026.1 221230610 7325159 2494427..2495707 1 NC_011896.1 manganese transport protein MntH 2495707 mntH 7325159 mntH Mycobacterium leprae Br4923 manganese transport protein MntH YP_002504026.1 2494427 D 561304 CDS YP_002504027.1 221230611 7325169 complement(2512464..2512898) 1 NC_011896.1 hypothetical protein 2512898 7325169 MLBr_02111 Mycobacterium leprae Br4923 hypothetical protein YP_002504027.1 2512464 R 561304 CDS YP_002504028.1 221230612 7325171 complement(2513795..2514340) 1 NC_011896.1 hypothetical protein 2514340 7325171 MLBr_02113 Mycobacterium leprae Br4923 hypothetical protein YP_002504028.1 2513795 R 561304 CDS YP_002504029.1 221230613 7325172 complement(2514337..2514507) 1 NC_011896.1 hypothetical protein 2514507 7325172 MLBr_02114 Mycobacterium leprae Br4923 hypothetical protein YP_002504029.1 2514337 R 561304 CDS YP_002504030.1 221230614 7325175 complement(2518695..2519438) 1 NC_011896.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2519438 echA6 7325175 echA6 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002504030.1 2518695 R 561304 CDS YP_002504031.1 221230615 7325176 complement(2521465..2521875) 1 NC_011896.1 hypothetical protein 2521875 7325176 MLBr_02121 Mycobacterium leprae Br4923 hypothetical protein YP_002504031.1 2521465 R 561304 CDS YP_002504032.1 221230616 7325178 2524075..2524776 1 NC_011896.1 two-component response regulator 2524776 7325178 MLBr_02123 Mycobacterium leprae Br4923 two-component response regulator YP_002504032.1 2524075 D 561304 CDS YP_002504033.1 221230617 7325179 2524794..2526134 1 NC_011896.1 sensor histidine kinase 2526134 7325179 MLBr_02124 Mycobacterium leprae Br4923 sensor histidine kinase YP_002504033.1 2524794 D 561304 CDS YP_002504034.1 221230618 7324996 complement(2530612..2530773) 1 NC_011896.1 PE-family protein (pseudogene); hypothetical protein 2530773 7324996 MLBr_02129 Mycobacterium leprae Br4923 hypothetical protein YP_002504034.1 2530612 R 561304 CDS YP_002504035.1 221230619 7325183 complement(2531539..2532834) 1 NC_011896.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 2532834 gltA 7325183 gltA Mycobacterium leprae Br4923 type II citrate synthase YP_002504035.1 2531539 R 561304 CDS YP_002504036.1 221230620 7325365 complement(2533083..2533703) 1 NC_011896.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2533703 pdxH 7325365 pdxH Mycobacterium leprae Br4923 pyridoxamine 5'-phosphate oxidase YP_002504036.1 2533083 R 561304 CDS YP_002504037.1 221230621 7325184 complement(2535738..2537405) 1 NC_011896.1 ferredoxin, ferredoxin-NADP reductase 2537405 fprB 7325184 fprB Mycobacterium leprae Br4923 ferredoxin, ferredoxin-NADP reductase YP_002504037.1 2535738 R 561304 CDS YP_002504038.1 221230622 7325310 complement(2537421..2538446) 1 NC_011896.1 transmembrane protein 2538446 7325310 MLBr_02135 Mycobacterium leprae Br4923 transmembrane protein YP_002504038.1 2537421 R 561304 CDS YP_002504039.1 221230623 7325185 2538660..2539790 1 NC_011896.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 2539790 serC 7325185 serC Mycobacterium leprae Br4923 phosphoserine aminotransferase YP_002504039.1 2538660 D 561304 CDS YP_002504040.1 221230624 7325980 2539908..2540663 1 NC_011896.1 hypothetical protein 2540663 7325980 MLBr_02137 Mycobacterium leprae Br4923 hypothetical protein YP_002504040.1 2539908 D 561304 CDS YP_002504041.1 221230625 7325188 complement(2541910..2542341) 1 NC_011896.1 MarR-family protein 2542341 7325188 MLBr_02140 Mycobacterium leprae Br4923 MarR-family protein YP_002504041.1 2541910 R 561304 CDS YP_002504042.1 221230626 7325189 2542545..2542820 1 NC_011896.1 hypothetical protein 2542820 7325189 MLBr_02141 Mycobacterium leprae Br4923 hypothetical protein YP_002504042.1 2542545 D 561304 CDS YP_002504043.1 221230627 7325190 complement(2542932..2543741) 1 NC_011896.1 hypothetical protein 2543741 7325190 MLBr_02142 Mycobacterium leprae Br4923 hypothetical protein YP_002504043.1 2542932 R 561304 CDS YP_002504044.1 221230628 7325191 2543851..2545590 1 NC_011896.1 hypothetical protein 2545590 7325191 MLBr_02143 Mycobacterium leprae Br4923 hypothetical protein YP_002504044.1 2543851 D 561304 CDS YP_002504045.1 221230629 7325192 2545598..2546086 1 NC_011896.1 hypothetical protein 2546086 7325192 MLBr_02144 Mycobacterium leprae Br4923 hypothetical protein YP_002504045.1 2545598 D 561304 CDS YP_002504046.1 221230630 7325263 complement(2551936..2552346) 1 NC_011896.1 cold shock protein 2552346 cspB 7325263 cspB Mycobacterium leprae Br4923 cold shock protein YP_002504046.1 2551936 R 561304 CDS YP_002504047.1 221230631 7324914 2554670..2555194 1 NC_011896.1 hypothetical protein 2555194 7324914 MLBr_02151 Mycobacterium leprae Br4923 hypothetical protein YP_002504047.1 2554670 D 561304 CDS YP_002504048.1 221230632 7324913 complement(2556641..2556865) 1 NC_011896.1 hypothetical protein 2556865 7324913 MLBr_02155 Mycobacterium leprae Br4923 hypothetical protein YP_002504048.1 2556641 R 561304 CDS YP_002504049.1 221230633 7325196 2556963..2559224 1 NC_011896.1 DNA-binding protein 2559224 7325196 MLBr_02156 Mycobacterium leprae Br4923 DNA-binding protein YP_002504049.1 2556963 D 561304 CDS YP_002504050.1 221230634 7325197 2559261..2560910 1 NC_011896.1 DNA helicase 2560910 7325197 MLBr_02157 Mycobacterium leprae Br4923 DNA helicase YP_002504050.1 2559261 D 561304 CDS YP_002504051.1 221230635 7325198 complement(2561022..2561414) 1 NC_011896.1 hypothetical protein 2561414 7325198 MLBr_02158 Mycobacterium leprae Br4923 hypothetical protein YP_002504051.1 2561022 R 561304 CDS YP_002504052.1 221230636 7325201 complement(2569083..2571227) 1 NC_011896.1 fatty oxidation complex alpha subunit 2571227 fadB 7325201 fadB Mycobacterium leprae Br4923 fatty oxidation complex alpha subunit YP_002504052.1 2569083 R 561304 CDS YP_002504053.1 221230637 7325240 complement(2571232..2572443) 1 NC_011896.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2572443 fadA 7325240 fadA Mycobacterium leprae Br4923 acetyl-CoA acetyltransferase YP_002504053.1 2571232 R 561304 CDS YP_002504054.1 221230638 7325204 2575887..2577596 1 NC_011896.1 pyruvate (or indolepyruvate) decarboxylase 2577596 pdc 7325204 pdc Mycobacterium leprae Br4923 pyruvate (or indolepyruvate) decarboxylase YP_002504054.1 2575887 D 561304 CDS YP_002504055.1 221230639 7325253 complement(2579131..2579355) 1 NC_011896.1 hypothetical protein 2579355 7325253 MLBr_02170 Mycobacterium leprae Br4923 hypothetical protein YP_002504055.1 2579131 R 561304 CDS YP_002504056.1 221230640 7325207 2583169..2583525 1 NC_011896.1 hypothetical protein 2583525 7325207 MLBr_02172 Mycobacterium leprae Br4923 hypothetical protein YP_002504056.1 2583169 D 561304 CDS YP_002504057.1 221230641 7325209 2586072..2586476 1 NC_011896.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2586476 cdd 7325209 cdd Mycobacterium leprae Br4923 cytidine deaminase YP_002504057.1 2586072 D 561304 CDS YP_002504058.1 221230642 7325210 2588118..2588375 1 NC_011896.1 hypothetical protein 2588375 7325210 MLBr_02176 Mycobacterium leprae Br4923 hypothetical protein YP_002504058.1 2588118 D 561304 CDS YP_002504059.1 221230643 7325211 complement(2588528..2589481) 1 NC_011896.1 uridine phosphorylase 2589481 7325211 MLBr_02177 Mycobacterium leprae Br4923 uridine phosphorylase YP_002504059.1 2588528 R 561304 CDS YP_002504060.1 221230644 7325212 complement(2589722..2589973) 1 NC_011896.1 hypothetical protein 2589973 7325212 MLBr_02178 Mycobacterium leprae Br4923 hypothetical protein YP_002504060.1 2589722 R 561304 CDS YP_002504061.1 221230645 7324819 2599141..2600157 1 NC_011896.1 acyl-[ACP] desaturase 2600157 desA1 7324819 desA1 Mycobacterium leprae Br4923 acyl-[ACP] desaturase YP_002504061.1 2599141 D 561304 CDS YP_002504062.1 221230646 7326167 2600201..2601355 1 NC_011896.1 NifR3/Smm1 family transcriptional regulator 2601355 7326167 MLBr_02186 Mycobacterium leprae Br4923 NifR3/Smm1 family transcriptional regulator YP_002504062.1 2600201 D 561304 CDS YP_002504063.1 221230647 7324821 2603503..2604171 1 NC_011896.1 phosphate transport system regulator 2604171 phoY1 7324821 phoY1 Mycobacterium leprae Br4923 phosphate transport system regulator YP_002504063.1 2603503 D 561304 CDS YP_002504064.1 221230648 7327400 complement(2604198..2604974) 1 NC_011896.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2604974 phoT 7327400 phoT Mycobacterium leprae Br4923 phosphate transporter ATP-binding protein YP_002504064.1 2604198 R 561304 CDS YP_002504065.1 221230649 7325026 complement(2606756..2608045) 1 NC_011896.1 phosphate-binding protein 3 2608045 phoS3 7325026 phoS3 Mycobacterium leprae Br4923 phosphate-binding protein 3 YP_002504065.1 2606756 R 561304 CDS YP_002504066.1 221230650 7327398 complement(2608038..2608973) 1 NC_011896.1 acetyltransferase 2608973 7327398 MLBr_02193 Mycobacterium leprae Br4923 acetyltransferase YP_002504066.1 2608038 R 561304 CDS YP_002504067.1 221230651 7324823 2609890..2610741 1 NC_011896.1 hypothetical protein 2610741 7324823 MLBr_02195 Mycobacterium leprae Br4923 hypothetical protein YP_002504067.1 2609890 D 561304 CDS YP_002504068.1 221230652 7324824 2610834..2611256 1 NC_011896.1 thiredoxin 2611256 thiX 7324824 thiX Mycobacterium leprae Br4923 thiredoxin YP_002504068.1 2610834 D 561304 CDS YP_002504069.1 221230653 7326018 2611469..2611954 1 NC_011896.1 hypothetical protein 2611954 7326018 MLBr_02197 Mycobacterium leprae Br4923 hypothetical protein YP_002504069.1 2611469 D 561304 CDS YP_002504070.1 221230654 7324825 2611986..2612819 1 NC_011896.1 thiosulfate sulfurtransferase 2612819 cysA3 7324825 cysA3 Mycobacterium leprae Br4923 thiosulfate sulfurtransferase YP_002504070.1 2611986 D 561304 CDS YP_002504071.1 221230655 7326147 2612821..2613123 1 NC_011896.1 hypothetical protein 2613123 7326147 MLBr_02199 Mycobacterium leprae Br4923 hypothetical protein YP_002504071.1 2612821 D 561304 CDS YP_002504072.1 221230656 7324826 2613382..2614068 1 NC_011896.1 hypothetical protein 2614068 7324826 MLBr_02200 Mycobacterium leprae Br4923 hypothetical protein YP_002504072.1 2613382 D 561304 CDS YP_002504073.1 221230657 7324827 complement(2615373..2615612) 1 NC_011896.1 hypothetical protein 2615612 7324827 MLBr_02201 Mycobacterium leprae Br4923 hypothetical protein YP_002504073.1 2615373 R 561304 CDS YP_002504074.1 221230658 7327347 2617795..2618895 1 NC_011896.1 hypothetical protein 2618895 7327347 MLBr_02203 Mycobacterium leprae Br4923 hypothetical protein YP_002504074.1 2617795 D 561304 CDS YP_002504075.1 221230659 7324829 2619064..2619252 1 NC_011896.1 hypothetical protein 2619252 7324829 MLBr_02204 Mycobacterium leprae Br4923 hypothetical protein YP_002504075.1 2619064 D 561304 CDS YP_002504076.1 221230660 7324830 complement(2619346..2620440) 1 NC_011896.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2620440 purM 7324830 purM Mycobacterium leprae Br4923 phosphoribosylaminoimidazole synthetase YP_002504076.1 2619346 R 561304 CDS YP_002504077.1 221230661 7325041 complement(2620540..2622210) 1 NC_011896.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2622210 purF 7325041 purF Mycobacterium leprae Br4923 amidophosphoribosyltransferase YP_002504077.1 2620540 R 561304 CDS YP_002504078.1 221230662 7325037 complement(2622222..2622617) 1 NC_011896.1 hypothetical protein 2622617 7325037 MLBr_02207 Mycobacterium leprae Br4923 hypothetical protein YP_002504078.1 2622222 R 561304 CDS YP_002504079.1 221230663 7325439 2624249..2625877 1 NC_011896.1 UDP-glucose-4-epimerase 2625877 cpsY 7325439 cpsY Mycobacterium leprae Br4923 UDP-glucose-4-epimerase YP_002504079.1 2624249 D 561304 CDS YP_002504080.1 221230664 7326128 complement(2625792..2626745) 1 NC_011896.1 hypothetical protein 2626745 7326128 MLBr_02210 Mycobacterium leprae Br4923 hypothetical protein YP_002504080.1 2625792 R 561304 CDS YP_002504081.1 221230665 7324832 complement(2626878..2629142) 1 NC_011896.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 2629142 purL 7324832 purL Mycobacterium leprae Br4923 phosphoribosylformylglycinamidine synthase II YP_002504081.1 2626878 R 561304 CDS YP_002504082.1 221230666 7324833 complement(2629994..2631325) 1 NC_011896.1 catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 2631325 pepC 7324833 pepC Mycobacterium leprae Br4923 aminopeptidase 2 YP_002504082.1 2629994 R 561304 CDS YP_002504083.1 221230667 7324837 complement(2635930..2636604) 1 NC_011896.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 2636604 purQ 7324837 purQ Mycobacterium leprae Br4923 phosphoribosylformylglycinamidine synthase I YP_002504083.1 2635930 R 561304 CDS YP_002504084.1 221230668 7325043 complement(2636601..2636840) 1 NC_011896.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 2636840 7325043 MLBr_02219A Mycobacterium leprae Br4923 phosphoribosylformylglycinamidine synthase subunit PurS YP_002504084.1 2636601 R 561304 CDS YP_002504085.1 221230669 7324844 complement(2642785..2644959) 1 NC_011896.1 protease II 2644959 ptrB 7324844 ptrB Mycobacterium leprae Br4923 protease II YP_002504085.1 2642785 R 561304 CDS YP_002504086.1 221230670 7325031 complement(2644956..2645849) 1 NC_011896.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2645849 purC 7325031 purC Mycobacterium leprae Br4923 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002504086.1 2644956 R 561304 CDS YP_002504087.1 221230671 7325034 2645915..2646535 1 NC_011896.1 hypothetical protein 2646535 7325034 MLBr_02228 Mycobacterium leprae Br4923 hypothetical protein YP_002504087.1 2645915 D 561304 CDS YP_002504088.1 221230672 7324846 complement(2647448..2648866) 1 NC_011896.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2648866 purB 7324846 purB Mycobacterium leprae Br4923 adenylosuccinate lyase YP_002504088.1 2647448 R 561304 CDS YP_002504089.1 221230673 7325339 complement(2653262..2654530) 1 NC_011896.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 2654530 purD 7325339 purD Mycobacterium leprae Br4923 phosphoribosylamine--glycine ligase YP_002504089.1 2653262 R 561304 CDS YP_002504090.1 221230674 7324850 2656371..2656775 1 NC_011896.1 hypothetical protein 2656775 7324850 MLBr_02237 Mycobacterium leprae Br4923 hypothetical protein YP_002504090.1 2656371 D 561304 CDS YP_002504091.1 221230675 7327380 complement(2660969..2661700) 1 NC_011896.1 hypothetical protein 2661700 7327380 MLBr_02242 Mycobacterium leprae Br4923 hypothetical protein YP_002504091.1 2660969 R 561304 CDS YP_002504092.1 221230676 7324854 complement(2667148..2667489) 1 NC_011896.1 hypothetical protein 2667489 7324854 MLBr_02244 Mycobacterium leprae Br4923 hypothetical protein YP_002504092.1 2667148 R 561304 CDS YP_002504093.1 221230677 7324857 2670247..2671797 1 NC_011896.1 hypothetical protein 2671797 cpsA 7324857 cpsA Mycobacterium leprae Br4923 hypothetical protein YP_002504093.1 2670247 D 561304 CDS YP_002504094.1 221230678 7324858 complement(2672645..2672962) 1 NC_011896.1 hypothetical protein 2672962 7324858 MLBr_02249 Mycobacterium leprae Br4923 hypothetical protein YP_002504094.1 2672645 R 561304 CDS YP_002504095.1 221230679 7325704 complement(2675692..2675928) 1 NC_011896.1 hypothetical protein 2675928 7325704 MLBr_02252 Mycobacterium leprae Br4923 hypothetical protein YP_002504095.1 2675692 R 561304 CDS YP_002504096.1 221230680 7324861 complement(2676244..2676459) 1 NC_011896.1 antigen 84 2676459 7324861 MLBr_02253 Mycobacterium leprae Br4923 antigen 84 YP_002504096.1 2676244 R 561304 CDS YP_002504097.1 221230681 7324862 2677188..2678684 1 NC_011896.1 trehalose-phosphate synthase 2678684 otsA 7324862 otsA Mycobacterium leprae Br4923 trehalose-phosphate synthase YP_002504097.1 2677188 D 561304 CDS YP_002504098.1 221230682 7324864 complement(2681302..2682408) 1 NC_011896.1 O-succinylbenzoic acid--CoA ligase 2682408 menE 7324864 menE Mycobacterium leprae Br4923 O-succinylbenzoic acid--CoA ligase YP_002504098.1 2681302 R 561304 CDS YP_002504099.1 221230683 7325449 complement(2682453..2682755) 1 NC_011896.1 hypothetical protein 2682755 7325449 MLBr_02258 Mycobacterium leprae Br4923 hypothetical protein YP_002504099.1 2682453 R 561304 CDS YP_002504100.1 221230684 7324865 complement(2682785..2683075) 1 NC_011896.1 hypothetical protein 2683075 7324865 MLBr_02259 Mycobacterium leprae Br4923 hypothetical protein YP_002504100.1 2682785 R 561304 CDS YP_002504101.1 221230685 7324866 complement(2683072..2684316) 1 NC_011896.1 low-affinity inorganic phosphate transporter 2684316 pitA 7324866 pitA Mycobacterium leprae Br4923 low-affinity inorganic phosphate transporter YP_002504101.1 2683072 R 561304 CDS YP_002504102.1 221230686 7327401 complement(2684414..2684830) 1 NC_011896.1 hypothetical protein 2684830 7327401 MLBr_02261 Mycobacterium leprae Br4923 hypothetical protein YP_002504102.1 2684414 R 561304 CDS YP_002504103.1 221230687 7324868 complement(2686484..2687386) 1 NC_011896.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2687386 menB 7324868 menB Mycobacterium leprae Br4923 naphthoate synthase YP_002504103.1 2686484 R 561304 CDS YP_002504104.1 221230688 7325447 complement(2687383..2687994) 1 NC_011896.1 hypothetical protein 2687994 7325447 MLBr_02264 Mycobacterium leprae Br4923 hypothetical protein YP_002504104.1 2687383 R 561304 CDS YP_002504105.1 221230689 7324869 complement(2687987..2688208) 1 NC_011896.1 hypothetical protein 2688208 7324869 MLBr_02265 Mycobacterium leprae Br4923 hypothetical protein YP_002504105.1 2687987 R 561304 CDS YP_002504106.1 221230690 7324871 2691722..2692726 1 NC_011896.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2692726 7324871 MLBr_02268 Mycobacterium leprae Br4923 O-succinylbenzoate synthase YP_002504106.1 2691722 D 561304 CDS YP_002504107.1 221230691 7324872 2692689..2693486 1 NC_011896.1 hydrolase 2693486 7324872 MLBr_02269 Mycobacterium leprae Br4923 hydrolase YP_002504107.1 2692689 D 561304 CDS YP_002504108.1 221230692 7324873 2693730..2695400 1 NC_011896.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2695400 menD 7324873 menD Mycobacterium leprae Br4923 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002504108.1 2693730 D 561304 CDS YP_002504109.1 221230693 7325448 2695428..2695955 1 NC_011896.1 hypothetical protein 2695955 7325448 MLBr_02271 Mycobacterium leprae Br4923 hypothetical protein YP_002504109.1 2695428 D 561304 CDS YP_002504110.1 221230694 7324875 2697208..2697924 1 NC_011896.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 2697924 ubiE 7324875 ubiE Mycobacterium leprae Br4923 ubiquinone/menaquinone biosynthesis methyltransferase YP_002504110.1 2697208 D 561304 CDS YP_002504111.1 221230695 7324876 complement(2697942..2698280) 1 NC_011896.1 hypothetical protein 2698280 7324876 MLBr_02274 Mycobacterium leprae Br4923 hypothetical protein YP_002504111.1 2697942 R 561304 CDS YP_002504112.1 221230696 7324878 complement(2698832..2700058) 1 NC_011896.1 FAD-linked oxidoreductase 2700058 7324878 MLBr_02276 Mycobacterium leprae Br4923 FAD-linked oxidoreductase YP_002504112.1 2698832 R 561304 CDS YP_002504113.1 221230697 7324879 2700089..2701081 1 NC_011896.1 polyprenyl diphosphate synthase component 2701081 7324879 MLBr_02277 Mycobacterium leprae Br4923 polyprenyl diphosphate synthase component YP_002504113.1 2700089 D 561304 CDS YP_002504114.1 221230698 7324880 2701192..2702055 1 NC_011896.1 metalloprotease; heat shock protein HtpX 2702055 htpX 7324880 htpX Mycobacterium leprae Br4923 heat shock protein HtpX YP_002504114.1 2701192 D 561304 CDS YP_002504115.1 221230699 7324700 complement(2702583..2704073) 1 NC_011896.1 transmembrane transport protein 2704073 7324700 MLBr_02279 Mycobacterium leprae Br4923 transmembrane transport protein YP_002504115.1 2702583 R 561304 CDS YP_002504116.1 221230700 7327295 2707657..2707971 1 NC_011896.1 hypothetical protein 2707971 7327295 MLBr_02283 Mycobacterium leprae Br4923 hypothetical protein YP_002504116.1 2707657 D 561304 CDS YP_002504117.1 221230701 7324885 2708363..2708722 1 NC_011896.1 hypothetical protein 2708722 7324885 MLBr_02284 Mycobacterium leprae Br4923 hypothetical protein YP_002504117.1 2708363 D 561304 CDS YP_002504118.1 221230702 7324889 complement(2712361..2712585) 1 NC_011896.1 hypothetical protein 2712585 7324889 MLBr_02288 Mycobacterium leprae Br4923 hypothetical protein YP_002504118.1 2712361 R 561304 CDS YP_002504119.1 221230703 7324890 complement(2713333..2714103) 1 NC_011896.1 hypothetical protein 2714103 7324890 MLBr_02289 Mycobacterium leprae Br4923 hypothetical protein YP_002504119.1 2713333 R 561304 CDS YP_002504120.1 221230704 7327187 complement(2720481..2721185) 1 NC_011896.1 hypothetical protein 2721185 7327187 MLBr_02295 Mycobacterium leprae Br4923 hypothetical protein YP_002504120.1 2720481 R 561304 CDS YP_002504121.1 221230705 7324893 2721389..2721934 1 NC_011896.1 hypothetical protein 2721934 7324893 MLBr_02296 Mycobacterium leprae Br4923 hypothetical protein YP_002504121.1 2721389 D 561304 CDS YP_002504122.1 221230706 7324894 2721935..2722909 1 NC_011896.1 hydrolase 2722909 7324894 MLBr_02297 Mycobacterium leprae Br4923 hydrolase YP_002504122.1 2721935 D 561304 CDS YP_002504123.1 221230707 7327416 complement(2722902..2724107) 1 NC_011896.1 membrane-associated serine protease 2724107 7327416 MLBr_02298 Mycobacterium leprae Br4923 membrane-associated serine protease YP_002504123.1 2722902 R 561304 CDS YP_002504124.1 221230708 7326030 complement(2724104..2724904) 1 NC_011896.1 hypothetical protein 2724904 7326030 MLBr_02299 Mycobacterium leprae Br4923 hypothetical protein YP_002504124.1 2724104 R 561304 CDS YP_002504125.1 221230709 7326031 complement(2724950..2725597) 1 NC_011896.1 hypothetical protein 2725597 7326031 MLBr_02300 Mycobacterium leprae Br4923 hypothetical protein YP_002504125.1 2724950 R 561304 CDS YP_002504126.1 221230710 7326032 complement(2725648..2726409) 1 NC_011896.1 endonuclease III 2726409 nth 7326032 nth Mycobacterium leprae Br4923 endonuclease III YP_002504126.1 2725648 R 561304 CDS YP_002504127.1 221230711 7327332 2726835..2727509 1 NC_011896.1 Crp/Fnr-family transcriptional regulator 2727509 7327332 MLBr_02302 Mycobacterium leprae Br4923 Crp/Fnr-family transcriptional regulator YP_002504127.1 2726835 D 561304 CDS YP_002504128.1 221230712 7326033 complement(2727587..2728375) 1 NC_011896.1 hydrolase 2728375 7326033 MLBr_02303 Mycobacterium leprae Br4923 hydrolase YP_002504128.1 2727587 R 561304 CDS YP_002504129.1 221230713 7326034 complement(2728381..2728905) 1 NC_011896.1 hypothetical protein 2728905 7326034 MLBr_02304 Mycobacterium leprae Br4923 hypothetical protein YP_002504129.1 2728381 R 561304 CDS YP_002504130.1 221230714 7326035 2729116..2730141 1 NC_011896.1 anion transporter protein 2730141 7326035 MLBr_02305 Mycobacterium leprae Br4923 anion transporter protein YP_002504130.1 2729116 D 561304 CDS YP_002504131.1 221230715 7326036 2730138..2731283 1 NC_011896.1 anion transporter protein 2731283 7326036 MLBr_02306 Mycobacterium leprae Br4923 anion transporter protein YP_002504131.1 2730138 D 561304 CDS YP_002504132.1 221230716 7326037 complement(2731388..2731633) 1 NC_011896.1 hypothetical protein 2731633 7326037 MLBr_02307 Mycobacterium leprae Br4923 hypothetical protein YP_002504132.1 2731388 R 561304 CDS YP_002504133.1 221230717 7326038 2732112..2734523 1 NC_011896.1 penicillin binding protein (class A) 2734523 pon1 7326038 pon1 Mycobacterium leprae Br4923 penicillin binding protein (class A) YP_002504133.1 2732112 D 561304 CDS YP_002504134.1 221230718 7324981 2734712..2735704 1 NC_011896.1 hypothetical protein 2735704 7324981 MLBr_02309 Mycobacterium leprae Br4923 hypothetical protein YP_002504134.1 2734712 D 561304 CDS YP_002504135.1 221230719 7326041 2739846..2740436 1 NC_011896.1 hypothetical protein 2740436 7326041 MLBr_02312 Mycobacterium leprae Br4923 hypothetical protein YP_002504135.1 2739846 D 561304 CDS YP_002504136.1 221230720 7326042 2740870..2741472 1 NC_011896.1 hypothetical protein 2741472 7326042 MLBr_02313 Mycobacterium leprae Br4923 hypothetical protein YP_002504136.1 2740870 D 561304 CDS YP_002504137.1 221230721 7326043 complement(2741738..2743264) 1 NC_011896.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2743264 glpK 7326043 glpK Mycobacterium leprae Br4923 glycerol kinase YP_002504137.1 2741738 R 561304 CDS YP_002504138.1 221230722 7324662 complement(2747077..2747724) 1 NC_011896.1 hypothetical protein 2747724 7324662 MLBr_02320 Mycobacterium leprae Br4923 hypothetical protein YP_002504138.1 2747077 R 561304 CDS YP_002504139.1 221230723 7326048 complement(2750393..2751403) 1 NC_011896.1 hypothetical protein 2751403 7326048 MLBr_02321 Mycobacterium leprae Br4923 hypothetical protein YP_002504139.1 2750393 R 561304 CDS YP_002504140.1 221230724 7326049 complement(2751549..2752604) 1 NC_011896.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 2752604 asd 7326049 asd Mycobacterium leprae Br4923 aspartate-semialdehyde dehydrogenase YP_002504140.1 2751549 R 561304 CDS YP_002504141.1 221230725 7327239 complement(2752604..2753869) 1 NC_011896.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 2753869 ask 7327239 ask Mycobacterium leprae Br4923 aspartate kinase YP_002504141.1 2752604 R 561304 CDS YP_002504142.1 221230726 7327240 2754565..2756388 1 NC_011896.1 2-isopropylmalate synthase 2756388 leuA 7327240 leuA Mycobacterium leprae Br4923 2-isopropylmalate synthase YP_002504142.1 2754565 D 561304 CDS YP_002504143.1 221230727 7326183 2757666..2758901 1 NC_011896.1 ligase 2758901 7326183 MLBr_02326 Mycobacterium leprae Br4923 ligase YP_002504143.1 2757666 D 561304 CDS YP_002504144.1 221230728 7326050 2758909..2759601 1 NC_011896.1 hypothetical protein 2759601 7326050 MLBr_02327 Mycobacterium leprae Br4923 hypothetical protein YP_002504144.1 2758909 D 561304 CDS YP_002504145.1 221230729 7326052 complement(2760555..2761166) 1 NC_011896.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 2761166 recR 7326052 recR Mycobacterium leprae Br4923 recombination protein RecR YP_002504145.1 2760555 R 561304 CDS YP_002504146.1 221230730 7326613 complement(2761178..2761528) 1 NC_011896.1 hypothetical protein 2761528 7326613 MLBr_02330 Mycobacterium leprae Br4923 hypothetical protein YP_002504146.1 2761178 R 561304 CDS YP_002504147.1 221230731 7326053 2761628..2762398 1 NC_011896.1 hypothetical protein 2762398 7326053 MLBr_02331 Mycobacterium leprae Br4923 hypothetical protein YP_002504147.1 2761628 D 561304 CDS YP_002504148.1 221230732 7326054 complement(2762414..2762851) 1 NC_011896.1 hypothetical protein 2762851 7326054 MLBr_02332 Mycobacterium leprae Br4923 hypothetical protein YP_002504148.1 2762414 R 561304 CDS YP_002504149.1 221230733 7326055 2762940..2764319 1 NC_011896.1 hypothetical protein 2764319 7326055 MLBr_02333 Mycobacterium leprae Br4923 hypothetical protein YP_002504149.1 2762940 D 561304 CDS YP_002504150.1 221230734 7326056 2764373..2765635 1 NC_011896.1 hypothetical protein 2765635 7326056 MLBr_02334 Mycobacterium leprae Br4923 hypothetical protein YP_002504150.1 2764373 D 561304 CDS YP_002504151.1 221230735 7326057 complement(2765632..2767467) 1 NC_011896.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 2767467 dnaZX 7326057 dnaZX Mycobacterium leprae Br4923 DNA polymerase III subunits gamma and tau YP_002504151.1 2765632 R 561304 CDS YP_002504152.1 221230736 7326184 complement(2767577..2768968) 1 NC_011896.1 hypothetical protein 2768968 7326184 MLBr_02336 Mycobacterium leprae Br4923 hypothetical protein YP_002504152.1 2767577 R 561304 CDS YP_002504153.1 221230737 7325984 2769367..2770119 1 NC_011896.1 hypothetical protein 2770119 7325984 MLBr_02337 Mycobacterium leprae Br4923 hypothetical protein YP_002504153.1 2769367 D 561304 CDS YP_002504154.1 221230738 7326061 complement(2779402..2781600) 1 NC_011896.1 regulatory protein 2781600 7326061 MLBr_02341 Mycobacterium leprae Br4923 regulatory protein YP_002504154.1 2779402 R 561304 CDS YP_002504155.1 221230739 7326065 complement(2786994..2787899) 1 NC_011896.1 hypothetical protein 2787899 7326065 MLBr_02346 Mycobacterium leprae Br4923 hypothetical protein YP_002504155.1 2786994 R 561304 CDS YP_002504156.1 221230740 7326066 2788198..2789208 1 NC_011896.1 hypothetical protein 2789208 7326066 MLBr_02347 Mycobacterium leprae Br4923 hypothetical protein YP_002504156.1 2788198 D 561304 CDS YP_002504157.1 221230741 7326067 2789399..2790664 1 NC_011896.1 glycosyl transferase family protein 2790664 7326067 MLBr_02348 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002504157.1 2789399 D 561304 CDS YP_002504158.1 221230742 7326068 complement(2790810..2792081) 1 NC_011896.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 2792081 7326068 MLBr_02349 Mycobacterium leprae Br4923 acyltransferase YP_002504158.1 2790810 R 561304 CDS YP_002504159.1 221230743 7326069 complement(2792130..2792960) 1 NC_011896.1 antibiotic resistance membrane protein 2792960 7326069 MLBr_02350 Mycobacterium leprae Br4923 antibiotic resistance membrane protein YP_002504159.1 2792130 R 561304 CDS YP_002504160.1 221230744 7326070 complement(2792957..2793823) 1 NC_011896.1 antibiotic resistance membrane protein 2793823 7326070 MLBr_02351 Mycobacterium leprae Br4923 antibiotic resistance membrane protein YP_002504160.1 2792957 R 561304 CDS YP_002504161.1 221230745 7326071 complement(2793820..2794815) 1 NC_011896.1 antibiotic resistance efflux protein 2794815 7326071 MLBr_02352 Mycobacterium leprae Br4923 antibiotic resistance efflux protein YP_002504161.1 2793820 R 561304 CDS YP_002504162.1 221230746 7326072 complement(2794826..2799295) 1 NC_011896.1 polyketide synthase 2799295 7326072 MLBr_02353 Mycobacterium leprae Br4923 polyketide synthase YP_002504162.1 2794826 R 561304 CDS YP_002504163.1 221230747 7326073 complement(2799302..2804770) 1 NC_011896.1 polyketide synthase 2804770 7326073 MLBr_02354 Mycobacterium leprae Br4923 polyketide synthase YP_002504163.1 2799302 R 561304 CDS YP_002504164.1 221230748 7326074 complement(2804767..2811372) 1 NC_011896.1 polyketide synthase 2811372 7326074 MLBr_02355 Mycobacterium leprae Br4923 polyketide synthase YP_002504164.1 2804767 R 561304 CDS YP_002504165.1 221230749 7326075 complement(2811369..2815991) 1 NC_011896.1 polyketide synthase 2815991 7326075 MLBr_02356 Mycobacterium leprae Br4923 polyketide synthase YP_002504165.1 2811369 R 561304 CDS YP_002504166.1 221230750 7326076 complement(2815992..2821607) 1 NC_011896.1 polyketide synthase 2821607 7326076 MLBr_02357 Mycobacterium leprae Br4923 polyketide synthase YP_002504166.1 2815992 R 561304 CDS YP_002504167.1 221230751 7326077 complement(2821604..2823355) 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2823355 fadD26 7326077 fadD26 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002504167.1 2821604 R 561304 CDS YP_002504168.1 221230752 7325249 complement(2824001..2824786) 1 NC_011896.1 thioesterase 2824786 7325249 MLBr_02359 Mycobacterium leprae Br4923 thioesterase YP_002504168.1 2824001 R 561304 CDS YP_002504169.1 221230753 7325278 complement(2834515..2834856) 1 NC_011896.1 hypothetical protein 2834856 7325278 MLBr_02366 Mycobacterium leprae Br4923 hypothetical protein YP_002504169.1 2834515 R 561304 CDS YP_002504170.1 221230754 7326089 2846260..2846724 1 NC_011896.1 hypothetical protein 2846724 7326089 MLBr_02377 Mycobacterium leprae Br4923 hypothetical protein YP_002504170.1 2846260 D 561304 CDS YP_002504171.1 221230755 7326090 2846721..2849600 1 NC_011896.1 hypothetical protein 2849600 7326090 MLBr_02378 Mycobacterium leprae Br4923 hypothetical protein YP_002504171.1 2846721 D 561304 CDS YP_002504172.1 221230756 7326091 complement(2849774..2850103) 1 NC_011896.1 hypothetical protein 2850103 7326091 MLBr_02379 Mycobacterium leprae Br4923 hypothetical protein YP_002504172.1 2849774 R 561304 CDS YP_002504173.1 221230757 7326092 complement(2850377..2850838) 1 NC_011896.1 hypothetical protein 2850838 7326092 MLBr_02380 Mycobacterium leprae Br4923 hypothetical protein YP_002504173.1 2850377 R 561304 CDS YP_002504174.1 221230758 7326098 2856775..2858178 1 NC_011896.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 2858178 lpd 7326098 lpd Mycobacterium leprae Br4923 dihydrolipoamide dehydrogenase YP_002504174.1 2856775 D 561304 CDS YP_002504175.1 221230759 7325404 2858196..2858501 1 NC_011896.1 hypothetical protein 2858501 7325404 MLBr_02388 Mycobacterium leprae Br4923 hypothetical protein YP_002504175.1 2858196 D 561304 CDS YP_002504176.1 221230760 7326100 complement(2861195..2861500) 1 NC_011896.1 hypothetical protein 2861500 7326100 MLBr_02390 Mycobacterium leprae Br4923 hypothetical protein YP_002504176.1 2861195 R 561304 CDS YP_002504177.1 221230761 7326101 complement(2861497..2862369) 1 NC_011896.1 hypothetical protein 2862369 7326101 MLBr_02391 Mycobacterium leprae Br4923 hypothetical protein YP_002504177.1 2861497 R 561304 CDS YP_002504178.1 221230762 7326102 2862474..2862908 1 NC_011896.1 hypothetical protein 2862908 7326102 MLBr_02392 Mycobacterium leprae Br4923 hypothetical protein YP_002504178.1 2862474 D 561304 CDS YP_002504179.1 221230763 7326103 2863132..2863626 1 NC_011896.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 2863626 greA 7326103 greA Mycobacterium leprae Br4923 transcription elongation factor GreA YP_002504179.1 2863132 D 561304 CDS YP_002504180.1 221230764 7324657 complement(2863689..2864855) 1 NC_011896.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 2864855 metB 7324657 metB Mycobacterium leprae Br4923 cystathionine gamma-synthase YP_002504180.1 2863689 R 561304 CDS YP_002504181.1 221230765 7325453 complement(2864935..2865684) 1 NC_011896.1 hypothetical protein 2865684 Ag36 7325453 Ag36 Mycobacterium leprae Br4923 hypothetical protein YP_002504181.1 2864935 R 561304 CDS YP_002504182.1 221230766 7327193 complement(2865834..2867228) 1 NC_011896.1 cystathionine beta-synthase 2867228 cysM2 7327193 cysM2 Mycobacterium leprae Br4923 cystathionine beta-synthase YP_002504182.1 2865834 R 561304 CDS YP_002504183.1 221230767 7325238 complement(2870547..2871404) 1 NC_011896.1 transmembrane protein 2871404 7325238 MLBr_02400 Mycobacterium leprae Br4923 transmembrane protein YP_002504183.1 2870547 R 561304 CDS YP_002504184.1 221230768 7326105 2871664..2872701 1 NC_011896.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 2872701 7326105 MLBr_02401 Mycobacterium leprae Br4923 3-hydroxyisobutyryl-CoA hydrolase YP_002504184.1 2871664 D 561304 CDS YP_002504185.1 221230769 7326106 2872726..2873499 1 NC_011896.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2873499 7326106 MLBr_02402 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002504185.1 2872726 D 561304 CDS YP_002504186.1 221230770 7324976 2877293..2878177 1 NC_011896.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 2878177 7324976 MLBr_02406 Mycobacterium leprae Br4923 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002504186.1 2877293 D 561304 CDS YP_002504187.1 221230771 7326109 complement(2878245..2878580) 1 NC_011896.1 hypothetical protein 2878580 7326109 MLBr_02407 Mycobacterium leprae Br4923 hypothetical protein YP_002504187.1 2878245 R 561304 CDS YP_002504188.1 221230772 7327415 complement(2879936..2880919) 1 NC_011896.1 cytochrome C biogenesis protein 2880919 7327415 MLBr_02409 Mycobacterium leprae Br4923 cytochrome C biogenesis protein YP_002504188.1 2879936 R 561304 CDS YP_002504189.1 221230773 7324732 complement(2880916..2882544) 1 NC_011896.1 hypothetical protein 2882544 7324732 MLBr_02410 Mycobacterium leprae Br4923 hypothetical protein YP_002504189.1 2880916 R 561304 CDS YP_002504190.1 221230774 7324733 complement(2882541..2883329) 1 NC_011896.1 cytochrome C-type biogenesis protein 2883329 7324733 MLBr_02411 Mycobacterium leprae Br4923 cytochrome C-type biogenesis protein YP_002504190.1 2882541 R 561304 CDS YP_002504191.1 221230775 7324734 complement(2883326..2883994) 1 NC_011896.1 hypothetical protein 2883994 7324734 MLBr_02412 Mycobacterium leprae Br4923 hypothetical protein YP_002504191.1 2883326 R 561304 CDS YP_002504192.1 221230776 7324735 complement(2883991..2884599) 1 NC_011896.1 phosphoglycerate mutase 2884599 7324735 MLBr_02413 Mycobacterium leprae Br4923 phosphoglycerate mutase YP_002504192.1 2883991 R 561304 CDS YP_002504193.1 221230777 7324736 complement(2884599..2885939) 1 NC_011896.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 2885939 hemL 7324736 hemL Mycobacterium leprae Br4923 glutamate-1-semialdehyde aminotransferase YP_002504193.1 2884599 R 561304 CDS YP_002504194.1 221230778 7324739 complement(2893697..2894686) 1 NC_011896.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 2894686 hemB 7324739 hemB Mycobacterium leprae Br4923 delta-aminolevulinic acid dehydratase YP_002504194.1 2893697 R 561304 CDS YP_002504195.1 221230779 7324671 complement(2894733..2896424) 1 NC_011896.1 uroporphyrin-III C-methyltransferase 2896424 hemD 7324671 hemD Mycobacterium leprae Br4923 uroporphyrin-III C-methyltransferase YP_002504195.1 2894733 R 561304 CDS YP_002504196.1 221230780 7324673 complement(2896431..2897387) 1 NC_011896.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 2897387 hemC 7324673 hemC Mycobacterium leprae Br4923 porphobilinogen deaminase YP_002504196.1 2896431 R 561304 CDS YP_002504197.1 221230781 7324672 complement(2897392..2898795) 1 NC_011896.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 2898795 hemA 7324672 hemA Mycobacterium leprae Br4923 glutamyl-tRNA reductase YP_002504197.1 2897392 R 561304 CDS YP_002504198.1 221230782 7324740 2899897..2900799 1 NC_011896.1 hypothetical protein 2900799 7324740 MLBr_02424 Mycobacterium leprae Br4923 hypothetical protein YP_002504198.1 2899897 D 561304 CDS YP_002504199.1 221230783 7324741 2900903..2901403 1 NC_011896.1 hypothetical protein 2901403 7324741 MLBr_02425 Mycobacterium leprae Br4923 hypothetical protein YP_002504199.1 2900903 D 561304 CDS YP_002504200.1 221230784 7324742 2901414..2902340 1 NC_011896.1 cyclopropane mycolic acid synthase 2902340 cmaA2 7324742 cmaA2 Mycobacterium leprae Br4923 cyclopropane mycolic acid synthase YP_002504200.1 2901414 D 561304 CDS YP_002504201.1 221230785 7326112 complement(2902369..2903481) 1 NC_011896.1 hypothetical protein 2903481 7326112 MLBr_02427 Mycobacterium leprae Br4923 hypothetical protein YP_002504201.1 2902369 R 561304 CDS YP_002504202.1 221230786 7324743 complement(2903478..2904572) 1 NC_011896.1 glucose epimerase/dehydratase 2904572 7324743 MLBr_02428 Mycobacterium leprae Br4923 glucose epimerase/dehydratase YP_002504202.1 2903478 R 561304 CDS YP_002504203.1 221230787 7324744 complement(2904643..2904744) 1 NC_011896.1 hypothetical protein 2904744 7324744 MLBr_02428A Mycobacterium leprae Br4923 hypothetical protein YP_002504203.1 2904643 R 561304 CDS YP_002504204.1 221230788 7324745 complement(2904987..2905247) 1 NC_011896.1 DNA-binding protein 2905247 7324745 MLBr_02429 Mycobacterium leprae Br4923 DNA-binding protein YP_002504204.1 2904987 R 561304 CDS YP_002504205.1 221230789 7324746 complement(2905388..2906272) 1 NC_011896.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 2906272 proC 7324746 proC Mycobacterium leprae Br4923 pyrroline-5-carboxylate reductase YP_002504205.1 2905388 R 561304 CDS YP_002504206.1 221230790 7324747 complement(2907033..2907875) 1 NC_011896.1 hypothetical protein 2907875 7324747 MLBr_02432 Mycobacterium leprae Br4923 hypothetical protein YP_002504206.1 2907033 R 561304 CDS YP_002504207.1 221230791 7324748 complement(2907906..2908973) 1 NC_011896.1 hypothetical protein 2908973 7324748 MLBr_02433 Mycobacterium leprae Br4923 hypothetical protein YP_002504207.1 2907906 R 561304 CDS YP_002504208.1 221230792 7324749 complement(2908970..2909989) 1 NC_011896.1 hypothetical protein 2909989 7324749 MLBr_02434 Mycobacterium leprae Br4923 hypothetical protein YP_002504208.1 2908970 R 561304 CDS YP_002504209.1 221230793 7324750 2910093..2910926 1 NC_011896.1 hypothetical protein 2910926 7324750 MLBr_02435 Mycobacterium leprae Br4923 hypothetical protein YP_002504209.1 2910093 D 561304 CDS YP_002504210.1 221230794 7324754 complement(2914387..2914983) 1 NC_011896.1 two-component system response regulator 2914983 7324754 MLBr_02439 Mycobacterium leprae Br4923 two-component system response regulator YP_002504210.1 2914387 R 561304 CDS YP_002504211.1 221230795 7324755 complement(2915026..2916351) 1 NC_011896.1 two-component system sensor histidine kinase 2916351 7324755 MLBr_02440 Mycobacterium leprae Br4923 two-component system sensor histidine kinase YP_002504211.1 2915026 R 561304 CDS YP_002504212.1 221230796 7324756 complement(2916514..2917257) 1 NC_011896.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 2917257 gpmA 7324756 gpmA Mycobacterium leprae Br4923 phosphoglyceromutase YP_002504212.1 2916514 R 561304 CDS YP_002504213.1 221230797 7324655 complement(2917270..2917824) 1 NC_011896.1 hypothetical protein 2917824 7324655 MLBr_02442 Mycobacterium leprae Br4923 hypothetical protein YP_002504213.1 2917270 R 561304 CDS YP_002504214.1 221230798 7324757 complement(2917898..2919184) 1 NC_011896.1 glycosyl transferase family protein 2919184 7324757 MLBr_02443 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002504214.1 2917898 R 561304 CDS YP_002504215.1 221230799 7324760 complement(2921281..2922606) 1 NC_011896.1 lipoprotein 2922606 7324760 MLBr_02446 Mycobacterium leprae Br4923 lipoprotein YP_002504215.1 2921281 R 561304 CDS YP_002504216.1 221230800 7324761 complement(2922687..2923790) 1 NC_011896.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 2923790 murB 7324761 murB Mycobacterium leprae Br4923 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002504216.1 2922687 R 561304 CDS YP_002504217.1 221230801 7324762 2924539..2925354 1 NC_011896.1 hydrolase 2925354 7324762 MLBr_02449 Mycobacterium leprae Br4923 hydrolase YP_002504217.1 2924539 D 561304 CDS YP_002504218.1 221230802 7324763 2925660..2926397 1 NC_011896.1 hypothetical protein 2926397 7324763 MLBr_02450 Mycobacterium leprae Br4923 hypothetical protein YP_002504218.1 2925660 D 561304 CDS YP_002504219.1 221230803 7324764 complement(2926454..2927134) 1 NC_011896.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 2927134 deoC 7324764 deoC Mycobacterium leprae Br4923 deoxyribose-phosphate aldolase YP_002504219.1 2926454 R 561304 CDS YP_002504220.1 221230804 7326165 complement(2927134..2927505) 1 NC_011896.1 hypothetical protein 2927505 7326165 MLBr_02452 Mycobacterium leprae Br4923 hypothetical protein YP_002504220.1 2927134 R 561304 CDS YP_002504221.1 221230805 7324765 complement(2927608..2927895) 1 NC_011896.1 hypothetical protein 2927895 7324765 MLBr_02453 Mycobacterium leprae Br4923 hypothetical protein YP_002504221.1 2927608 R 561304 CDS YP_002504222.1 221230806 7324766 complement(2928015..2928581) 1 NC_011896.1 hemagglutinin 2928581 7324766 MLBr_02454 Mycobacterium leprae Br4923 hemagglutinin YP_002504222.1 2928015 R 561304 CDS YP_002504223.1 221230807 7324769 2930076..2930777 1 NC_011896.1 TetR family transcriptional regulator 2930777 7324769 MLBr_02457 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002504223.1 2930076 D 561304 CDS YP_002504224.1 221230808 7324771 2931960..2932847 1 NC_011896.1 Mycolic acid synthase 2932847 umaA2 7324771 umaA2 Mycobacterium leprae Br4923 Mycolic acid synthase YP_002504224.1 2931960 D 561304 CDS YP_002504225.1 221230809 7327298 complement(2933984..2934847) 1 NC_011896.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 2934847 fadB2 7327298 fadB2 Mycobacterium leprae Br4923 3-hydroxybutyryl-CoA dehydrogenase YP_002504225.1 2933984 R 561304 CDS YP_002504226.1 221230810 7324704 complement(2936649..2937443) 1 NC_011896.1 hypothetical protein 2937443 7324704 MLBr_02463 Mycobacterium leprae Br4923 hypothetical protein YP_002504226.1 2936649 R 561304 CDS YP_002504227.1 221230811 7324773 2939075..2939641 1 NC_011896.1 hypothetical protein 2939641 7324773 MLBr_02465 Mycobacterium leprae Br4923 hypothetical protein YP_002504227.1 2939075 D 561304 CDS YP_002504228.1 221230812 7324775 2940802..2941590 1 NC_011896.1 UDP pyrophosphate synthetase 2941590 7324775 MLBr_02467 Mycobacterium leprae Br4923 UDP pyrophosphate synthetase YP_002504228.1 2940802 D 561304 CDS YP_002504229.1 221230813 7324776 complement(2941925..2942305) 1 NC_011896.1 hypothetical protein 2942305 7324776 MLBr_02468 Mycobacterium leprae Br4923 hypothetical protein YP_002504229.1 2941925 R 561304 CDS YP_002504230.1 221230814 7324778 complement(2947033..2948016) 1 NC_011896.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 2948016 7324778 MLBr_02472 Mycobacterium leprae Br4923 prephenate dehydrogenase YP_002504230.1 2947033 R 561304 CDS YP_002504231.1 221230815 7324779 2948147..2948626 1 NC_011896.1 hypothetical protein 2948626 7324779 MLBr_02473 Mycobacterium leprae Br4923 hypothetical protein YP_002504231.1 2948147 D 561304 CDS YP_002504232.1 221230816 7324780 2948641..2949156 1 NC_011896.1 cytidine/deoxycytidylate deaminase 2949156 7324780 MLBr_02474 Mycobacterium leprae Br4923 cytidine/deoxycytidylate deaminase YP_002504232.1 2948641 D 561304 CDS YP_002504233.1 221230817 7324782 complement(2950514..2950681) 1 NC_011896.1 hypothetical protein 2950681 7324782 MLBr_02476 Mycobacterium leprae Br4923 hypothetical protein YP_002504233.1 2950514 R 561304 CDS YP_002504234.1 221230818 7324784 complement(2952624..2953013) 1 NC_011896.1 hypothetical protein 2953013 7324784 MLBr_02478 Mycobacterium leprae Br4923 hypothetical protein YP_002504234.1 2952624 R 561304 CDS YP_002504235.1 221230819 7324791 complement(2959327..2959875) 1 NC_011896.1 RNA methyltransferase 2959875 7324791 MLBr_02485 Mycobacterium leprae Br4923 RNA methyltransferase YP_002504235.1 2959327 R 561304 CDS YP_002504236.1 221230820 7324793 complement(2960867..2961406) 1 NC_011896.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 2961406 pyrE 7324793 pyrE Mycobacterium leprae Br4923 orotate phosphoribosyltransferase YP_002504236.1 2960867 R 561304 CDS YP_002504237.1 221230821 7324795 complement(2962142..2963002) 1 NC_011896.1 hypothetical protein 2963002 7324795 MLBr_02489 Mycobacterium leprae Br4923 hypothetical protein YP_002504237.1 2962142 R 561304 CDS YP_002504238.1 221230822 7324796 complement(2963087..2965633) 1 NC_011896.1 heat shock protein 2965633 clpB 7324796 clpB Mycobacterium leprae Br4923 heat shock protein YP_002504238.1 2963087 R 561304 CDS YP_002504239.1 221230823 7327273 2966564..2967565 1 NC_011896.1 hypothetical protein 2967565 7327273 MLBr_02491 Mycobacterium leprae Br4923 hypothetical protein YP_002504239.1 2966564 D 561304 CDS YP_002504240.1 221230824 7324798 complement(2969165..2969563) 1 NC_011896.1 heat shock regulator 2969563 hspR 7324798 hspR Mycobacterium leprae Br4923 heat shock regulator YP_002504240.1 2969165 R 561304 CDS YP_002504241.1 221230825 7324698 complement(2969567..2970733) 1 NC_011896.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 2970733 dnaJ 7324698 dnaJ Mycobacterium leprae Br4923 molecular chaperone DnaJ YP_002504241.1 2969567 R 561304 CDS YP_002504242.1 221230826 7326179 complement(2970747..2971436) 1 NC_011896.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2971436 grpE 7326179 grpE Mycobacterium leprae Br4923 heat shock protein GrpE YP_002504242.1 2970747 R 561304 CDS YP_002504243.1 221230827 7324661 complement(2971433..2973295) 1 NC_011896.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 2973295 dnaK 7324661 dnaK Mycobacterium leprae Br4923 molecular chaperone DnaK YP_002504243.1 2971433 R 561304 CDS YP_002504244.1 221230828 7326181 2973984..2974457 1 NC_011896.1 hypothetical protein 2974457 7326181 MLBr_02497 Mycobacterium leprae Br4923 hypothetical protein YP_002504244.1 2973984 D 561304 CDS YP_002504245.1 221230829 7324799 2974487..2975146 1 NC_011896.1 enoyl-CoA hydratase 2975146 7324799 MLBr_02498 Mycobacterium leprae Br4923 enoyl-CoA hydratase YP_002504245.1 2974487 D 561304 CDS YP_002504246.1 221230830 7324802 2980048..2982690 1 NC_011896.1 iron-sulfur-binding reductase 2982690 7324802 MLBr_02501 Mycobacterium leprae Br4923 iron-sulfur-binding reductase YP_002504246.1 2980048 D 561304 CDS YP_002504247.1 221230831 7324803 2982699..2984012 1 NC_011896.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2984012 7324803 MLBr_02502 Mycobacterium leprae Br4923 aminotransferase YP_002504247.1 2982699 D 561304 CDS YP_002504248.1 221230832 7324804 complement(2984167..2985033) 1 NC_011896.1 glucose-1-phosphate thymidylyltransferase 2985033 rfbA 7324804 rfbA Mycobacterium leprae Br4923 glucose-1-phosphate thymidylyltransferase YP_002504248.1 2984167 R 561304 CDS YP_002504249.1 221230833 7327296 complement(2987816..2988388) 1 NC_011896.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2988388 dcd 7327296 dcd Mycobacterium leprae Br4923 deoxycytidine triphosphate deaminase YP_002504249.1 2987816 R 561304 CDS YP_002504250.1 221230834 7325461 complement(2999683..3000075) 1 NC_011896.1 hypothetical protein 3000075 7325461 MLBr_02518 Mycobacterium leprae Br4923 hypothetical protein YP_002504250.1 2999683 R 561304 CDS YP_002504251.1 221230835 7325465 complement(3004457..3005113) 1 NC_011896.1 hypothetical protein 3005113 7325465 MLBr_02522 Mycobacterium leprae Br4923 hypothetical protein YP_002504251.1 3004457 R 561304 CDS YP_002504252.1 221230836 7325469 complement(3009123..3010142) 1 NC_011896.1 hypothetical protein 3010142 7325469 MLBr_02527 Mycobacterium leprae Br4923 hypothetical protein YP_002504252.1 3009123 R 561304 CDS YP_002504253.1 221230837 7325470 complement(3010139..3011566) 1 NC_011896.1 protease 3011566 7325470 MLBr_02528 Mycobacterium leprae Br4923 protease YP_002504253.1 3010139 R 561304 CDS YP_002504254.1 221230838 7325471 complement(3011577..3013034) 1 NC_011896.1 hypothetical protein 3013034 7325471 MLBr_02529 Mycobacterium leprae Br4923 hypothetical protein YP_002504254.1 3011577 R 561304 CDS YP_002504255.1 221230839 7325472 complement(3013176..3014045) 1 NC_011896.1 DNA-binding protein 3014045 7325472 MLBr_02530 Mycobacterium leprae Br4923 DNA-binding protein YP_002504255.1 3013176 R 561304 CDS YP_002504256.1 221230840 7325473 complement(3014056..3014346) 1 NC_011896.1 cell surface protein 3014346 7325473 MLBr_02531 Mycobacterium leprae Br4923 cell surface protein YP_002504256.1 3014056 R 561304 CDS YP_002504257.1 221230841 7325474 complement(3014385..3014681) 1 NC_011896.1 PE-family protein 3014681 7325474 MLBr_02532 Mycobacterium leprae Br4923 PE-family protein YP_002504257.1 3014385 R 561304 CDS YP_002504258.1 221230842 7327370 complement(3015970..3016278) 1 NC_011896.1 PE-family protein 3016278 7327370 MLBr_02534 Mycobacterium leprae Br4923 PE-family protein YP_002504258.1 3015970 R 561304 CDS YP_002504259.1 221230843 7325476 complement(3016313..3020302) 1 NC_011896.1 hypothetical protein 3020302 7325476 MLBr_02535 Mycobacterium leprae Br4923 hypothetical protein YP_002504259.1 3016313 R 561304 CDS YP_002504260.1 221230844 7325477 complement(3020299..3021957) 1 NC_011896.1 hypothetical protein 3021957 7325477 MLBr_02536 Mycobacterium leprae Br4923 hypothetical protein YP_002504260.1 3020299 R 561304 CDS YP_002504261.1 221230845 7325478 complement(3021950..3023872) 1 NC_011896.1 hypothetical protein 3023872 7325478 MLBr_02537 Mycobacterium leprae Br4923 hypothetical protein YP_002504261.1 3021950 R 561304 CDS YP_002504262.1 221230846 7325281 complement(3033527..3035173) 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3035173 fadD2 7325281 fadD2 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002504262.1 3033527 R 561304 CDS YP_002504263.1 221230847 7325296 3037405..3038073 1 NC_011896.1 hypothetical protein 3038073 7325296 MLBr_02549 Mycobacterium leprae Br4923 hypothetical protein YP_002504263.1 3037405 D 561304 CDS YP_002504264.1 221230848 7325486 3038095..3039012 1 NC_011896.1 hypothetical protein 3039012 7325486 MLBr_02550 Mycobacterium leprae Br4923 hypothetical protein YP_002504264.1 3038095 D 561304 CDS YP_002504265.1 221230849 7325487 3039059..3039607 1 NC_011896.1 aminoglycoside 2'-N-acetyltransferase 3039607 aac 7325487 aac Mycobacterium leprae Br4923 aminoglycoside 2'-N-acetyltransferase YP_002504265.1 3039059 D 561304 CDS YP_002504266.1 221230850 7324696 3049162..3049458 1 NC_011896.1 hypothetical protein 3049458 7324696 MLBr_02557 Mycobacterium leprae Br4923 hypothetical protein YP_002504266.1 3049162 D 561304 CDS YP_002504267.1 221230851 7325492 complement(3053090..3053578) 1 NC_011896.1 oxidoreductase 3053578 7325492 MLBr_02561 Mycobacterium leprae Br4923 oxidoreductase YP_002504267.1 3053090 R 561304 CDS YP_002504268.1 221230852 7325493 3054455..3054745 1 NC_011896.1 hypothetical protein 3054745 7325493 MLBr_02562 Mycobacterium leprae Br4923 hypothetical protein YP_002504268.1 3054455 D 561304 CDS YP_002504269.1 221230853 7325494 3055097..3056932 1 NC_011896.1 acyl-CoA dehydrogenase 3056932 fadE5 7325494 fadE5 Mycobacterium leprae Br4923 acyl-CoA dehydrogenase YP_002504269.1 3055097 D 561304 CDS YP_002504270.1 221230854 7325280 complement(3057354..3058727) 1 NC_011896.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3058727 fadA2 7325280 fadA2 Mycobacterium leprae Br4923 acetyl-CoA acetyltransferase YP_002504270.1 3057354 R 561304 CDS YP_002504271.1 221230855 7325237 3058832..3060196 1 NC_011896.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3060196 fabG 7325237 fabG Mycobacterium leprae Br4923 3-ketoacyl-ACP reductase YP_002504271.1 3058832 D 561304 CDS YP_002504272.1 221230856 7325234 3061237..3062139 1 NC_011896.1 hypothetical protein 3062139 7325234 MLBr_02566 Mycobacterium leprae Br4923 hypothetical protein YP_002504272.1 3061237 D 561304 CDS YP_002504273.1 221230857 7325495 3062248..3062727 1 NC_011896.1 hypothetical protein 3062727 7325495 MLBr_02567 Mycobacterium leprae Br4923 hypothetical protein YP_002504273.1 3062248 D 561304 CDS YP_002504274.1 221230858 7325496 complement(3063130..3063756) 1 NC_011896.1 TetR family transcriptional regulator 3063756 7325496 MLBr_02568 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002504274.1 3063130 R 561304 CDS YP_002504275.1 221230859 7325497 complement(3063826..3064989) 1 NC_011896.1 glycosyl hydrolase 3064989 7325497 MLBr_02569 Mycobacterium leprae Br4923 glycosyl hydrolase YP_002504275.1 3063826 R 561304 CDS YP_002504276.1 221230860 7325498 3065136..3065309 1 NC_011896.1 hypothetical protein 3065309 7325498 MLBr_02569A Mycobacterium leprae Br4923 hypothetical protein YP_002504276.1 3065136 D 561304 CDS YP_002504277.1 221230861 7325499 3065425..3069642 1 NC_011896.1 integral membrane protein 3069642 7325499 MLBr_02570 Mycobacterium leprae Br4923 integral membrane protein YP_002504277.1 3065425 D 561304 CDS YP_002504278.1 221230862 7325501 3072552..3073925 1 NC_011896.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3073925 gabD1 7325501 gabD1 Mycobacterium leprae Br4923 succinate-semialdehyde dehydrogenase YP_002504278.1 3072552 D 561304 CDS YP_002504279.1 221230863 7325505 complement(3080043..3081197) 1 NC_011896.1 acyltransferase 3081197 7325505 MLBr_02580 Mycobacterium leprae Br4923 acyltransferase YP_002504279.1 3080043 R 561304 CDS YP_002504280.1 221230864 7325506 3081406..3082689 1 NC_011896.1 integral membrane protein 3082689 7325506 MLBr_02581 Mycobacterium leprae Br4923 integral membrane protein YP_002504280.1 3081406 D 561304 CDS YP_002504281.1 221230865 7325507 3082791..3084593 1 NC_011896.1 hypothetical protein 3084593 7325507 MLBr_02582 Mycobacterium leprae Br4923 hypothetical protein YP_002504281.1 3082791 D 561304 CDS YP_002504282.1 221230866 7325508 complement(3084956..3086140) 1 NC_011896.1 glycosyl transferase family protein 3086140 7325508 MLBr_02583 Mycobacterium leprae Br4923 glycosyl transferase family protein YP_002504282.1 3084956 R 561304 CDS YP_002504283.1 221230867 7325509 3086193..3087002 1 NC_011896.1 hypothetical protein 3087002 7325509 MLBr_02584 Mycobacterium leprae Br4923 hypothetical protein YP_002504283.1 3086193 D 561304 CDS YP_002504284.1 221230868 7325258 3090634..3091437 1 NC_011896.1 hypothetical protein 3091437 yrbE1A 7325258 yrbE1A Mycobacterium leprae Br4923 hypothetical protein YP_002504284.1 3090634 D 561304 CDS YP_002504285.1 221230869 7327326 3091441..3092310 1 NC_011896.1 hypothetical protein 3092310 yrbE1B 7327326 yrbE1B Mycobacterium leprae Br4923 hypothetical protein YP_002504285.1 3091441 D 561304 CDS YP_002504286.1 221230870 7327327 3092314..3093639 1 NC_011896.1 cell invasion protein 3093639 mce1A 7327327 mce1A Mycobacterium leprae Br4923 cell invasion protein YP_002504286.1 3092314 D 561304 CDS YP_002504287.1 221230871 7325440 3093636..3094676 1 NC_011896.1 hypothetical protein 3094676 mce1B 7325440 mce1B Mycobacterium leprae Br4923 hypothetical protein YP_002504287.1 3093636 D 561304 CDS YP_002504288.1 221230872 7325441 3094673..3096232 1 NC_011896.1 hypothetical protein 3096232 mce1C 7325441 mce1C Mycobacterium leprae Br4923 hypothetical protein YP_002504288.1 3094673 D 561304 CDS YP_002504289.1 221230873 7325442 3096229..3097824 1 NC_011896.1 hypothetical protein 3097824 mce1D 7325442 mce1D Mycobacterium leprae Br4923 hypothetical protein YP_002504289.1 3096229 D 561304 CDS YP_002504290.1 221230874 7325443 3097821..3098999 1 NC_011896.1 lipoprotein 3098999 lprK 7325443 lprK Mycobacterium leprae Br4923 lipoprotein YP_002504290.1 3097821 D 561304 CDS YP_002504291.1 221230875 7325424 3098993..3100543 1 NC_011896.1 hypothetical protein 3100543 mce1F 7325424 mce1F Mycobacterium leprae Br4923 hypothetical protein YP_002504291.1 3098993 D 561304 CDS YP_002504292.1 221230876 7325444 3100677..3101225 1 NC_011896.1 hypothetical protein 3101225 7325444 MLBr_02595 Mycobacterium leprae Br4923 hypothetical protein YP_002504292.1 3100677 D 561304 CDS YP_002504293.1 221230877 7325512 3101222..3102199 1 NC_011896.1 hypothetical protein 3102199 7325512 MLBr_02596 Mycobacterium leprae Br4923 hypothetical protein YP_002504293.1 3101222 D 561304 CDS YP_002504294.1 221230878 7325513 3102196..3102750 1 NC_011896.1 hypothetical protein 3102750 7325513 MLBr_02597 Mycobacterium leprae Br4923 hypothetical protein YP_002504294.1 3102196 D 561304 CDS YP_002504295.1 221230879 7325514 3102840..3103394 1 NC_011896.1 hypothetical protein 3103394 7325514 MLBr_02598 Mycobacterium leprae Br4923 hypothetical protein YP_002504295.1 3102840 D 561304 CDS YP_002504296.1 221230880 7325425 complement(3104529..3105926) 1 NC_011896.1 hypothetical protein 3105926 7325425 MLBr_02600 Mycobacterium leprae Br4923 hypothetical protein YP_002504296.1 3104529 R 561304 CDS YP_002504297.1 221230881 7325989 3107415..3108254 1 NC_011896.1 hypothetical protein 3108254 7325989 MLBr_02603 Mycobacterium leprae Br4923 hypothetical protein YP_002504297.1 3107415 D 561304 CDS YP_002504298.1 221230882 7325518 3108315..3109064 1 NC_011896.1 hypothetical protein 3109064 7325518 MLBr_02604 Mycobacterium leprae Br4923 hypothetical protein YP_002504298.1 3108315 D 561304 CDS YP_002504299.1 221230883 7325519 3109061..3109567 1 NC_011896.1 hypothetical protein 3109567 7325519 MLBr_02605 Mycobacterium leprae Br4923 hypothetical protein YP_002504299.1 3109061 D 561304 CDS YP_002504300.1 221230884 7325521 complement(3112893..3114587) 1 NC_011896.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3114587 ilvD 7325521 ilvD Mycobacterium leprae Br4923 dihydroxy-acid dehydratase YP_002504300.1 3112893 R 561304 CDS YP_002504301.1 221230885 7324711 3114651..3115058 1 NC_011896.1 hypothetical protein 3115058 7324711 MLBr_02609 Mycobacterium leprae Br4923 hypothetical protein YP_002504301.1 3114651 D 561304 CDS YP_002504302.1 221230886 7325525 complement(3118634..3120637) 1 NC_011896.1 zinc metalloprotease 3120637 7325525 MLBr_02613 Mycobacterium leprae Br4923 zinc metalloprotease YP_002504302.1 3118634 R 561304 CDS YP_002504303.1 221230887 7325526 3120697..3121371 1 NC_011896.1 hypothetical protein 3121371 7325526 MLBr_02614 Mycobacterium leprae Br4923 hypothetical protein YP_002504303.1 3120697 D 561304 CDS YP_002504304.1 221230888 7325527 3121368..3122057 1 NC_011896.1 hypothetical protein 3122057 7325527 MLBr_02615 Mycobacterium leprae Br4923 hypothetical protein YP_002504304.1 3121368 D 561304 CDS YP_002504305.1 221230889 7325528 complement(3122136..3122648) 1 NC_011896.1 hypothetical protein 3122648 7325528 MLBr_02616 Mycobacterium leprae Br4923 hypothetical protein YP_002504305.1 3122136 R 561304 CDS YP_002504306.1 221230890 7325529 complement(3122645..3125686) 1 NC_011896.1 hypothetical protein 3125686 7325529 MLBr_02617 Mycobacterium leprae Br4923 hypothetical protein YP_002504306.1 3122645 R 561304 CDS YP_002504307.1 221230891 7325530 complement(3126303..3127361) 1 NC_011896.1 integral membrane protein 3127361 7325530 MLBr_02618 Mycobacterium leprae Br4923 integral membrane protein YP_002504307.1 3126303 R 561304 CDS YP_002504308.1 221230892 7325532 complement(3128702..3131569) 1 NC_011896.1 hypothetical protein 3131569 7325532 MLBr_02620 Mycobacterium leprae Br4923 hypothetical protein YP_002504308.1 3128702 R 561304 CDS YP_002504309.1 221230893 7325533 complement(3131649..3132236) 1 NC_011896.1 hypothetical protein 3132236 7325533 MLBr_02621 Mycobacterium leprae Br4923 hypothetical protein YP_002504309.1 3131649 R 561304 CDS YP_002504310.1 221230894 7325534 complement(3132445..3133137) 1 NC_011896.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3133137 trmB 7325534 trmB Mycobacterium leprae Br4923 tRNA (guanine-N(7)-)-methyltransferase YP_002504310.1 3132445 R 561304 CDS YP_002504311.1 221230895 7325536 3135143..3136972 1 NC_011896.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 3136972 pckA 7325536 pckA Mycobacterium leprae Br4923 phosphoenolpyruvate carboxykinase YP_002504311.1 3135143 D 561304 CDS YP_002504312.1 221230896 7325275 3140130..3141149 1 NC_011896.1 hypothetical protein 3141149 7325275 MLBr_02627 Mycobacterium leprae Br4923 hypothetical protein YP_002504312.1 3140130 D 561304 CDS YP_002504313.1 221230897 7325259 complement(3144441..3144911) 1 NC_011896.1 hypothetical protein 3144911 7325259 MLBr_02629 Mycobacterium leprae Br4923 hypothetical protein YP_002504313.1 3144441 R 561304 CDS YP_002504314.1 221230898 7325538 complement(3145095..3145466) 1 NC_011896.1 hypothetical protein 3145466 7325538 MLBr_02630 Mycobacterium leprae Br4923 hypothetical protein YP_002504314.1 3145095 R 561304 CDS YP_002504315.1 221230899 7325539 complement(3147564..3148913) 1 NC_011896.1 oxidoreductase 3148913 7325539 MLBr_02631 Mycobacterium leprae Br4923 oxidoreductase YP_002504315.1 3147564 R 561304 CDS YP_002504316.1 221230900 7327114 complement(3151333..3152751) 1 NC_011896.1 pyridine transhydrogenase subunit beta 3152751 pntB 7327114 pntB Mycobacterium leprae Br4923 pyridine transhydrogenase subunit beta YP_002504316.1 3151333 R 561304 CDS YP_002504317.1 221230901 7324979 complement(3152748..3153086) 1 NC_011896.1 pyridine transhydrogenase subunit alpha2 3153086 pntAB 7324979 pntAB Mycobacterium leprae Br4923 pyridine transhydrogenase subunit alpha2 YP_002504317.1 3152748 R 561304 CDS YP_002504318.1 221230902 7324978 complement(3153079..3154182) 1 NC_011896.1 pyridine transhydrogenase subunit alpha1 3154182 pntAA 7324978 pntAA Mycobacterium leprae Br4923 pyridine transhydrogenase subunit alpha1 YP_002504318.1 3153079 R 561304 CDS YP_002504319.1 221230903 7327115 complement(3157231..3158736) 1 NC_011896.1 aldehyde dehydrogenase 3158736 7327115 MLBr_02639 Mycobacterium leprae Br4923 aldehyde dehydrogenase YP_002504319.1 3157231 R 561304 CDS YP_002504320.1 221230904 7327116 complement(3158924..3159856) 1 NC_011896.1 hypothetical protein 3159856 7327116 MLBr_02640 Mycobacterium leprae Br4923 hypothetical protein YP_002504320.1 3158924 R 561304 CDS YP_002504321.1 221230905 7327123 3166734..3167267 1 NC_011896.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 3167267 7327123 MLBr_02647 Mycobacterium leprae Br4923 methionine sulfoxide reductase A YP_002504321.1 3166734 D 561304 CDS YP_002504322.1 221230906 7327125 complement(3169193..3170008) 1 NC_011896.1 hypothetical protein 3170008 7327125 MLBr_02649 Mycobacterium leprae Br4923 hypothetical protein YP_002504322.1 3169193 R 561304 CDS YP_002504323.1 221230907 7327127 3173158..3173475 1 NC_011896.1 hypothetical protein 3173475 7327127 MLBr_02651 Mycobacterium leprae Br4923 hypothetical protein YP_002504323.1 3173158 D 561304 CDS YP_002504324.1 221230908 7327130 3176596..3177093 1 NC_011896.1 hypothetical protein 3177093 7327130 MLBr_02654 Mycobacterium leprae Br4923 hypothetical protein YP_002504324.1 3176596 D 561304 CDS YP_002504325.1 221230909 7327131 3177682..3178683 1 NC_011896.1 antigen 85A, mycolyltransferase 3178683 fbpC2 7327131 fbpC2 Mycobacterium leprae Br4923 antigen 85A, mycolyltransferase YP_002504325.1 3177682 D 561304 CDS YP_002504326.1 221230910 7327134 complement(3181943..3183007) 1 NC_011896.1 serine protease 3183007 7327134 MLBr_02659 Mycobacterium leprae Br4923 serine protease YP_002504326.1 3181943 R 561304 CDS YP_002504327.1 221230911 7325323 complement(3185729..3187375) 1 NC_011896.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3187375 7325323 MLBr_02661 Mycobacterium leprae Br4923 acyl-CoA synthetase YP_002504327.1 3185729 R 561304 CDS YP_002504328.1 221230912 7327342 complement(3189244..3190176) 1 NC_011896.1 LysR family transcriptional regulator 3190176 oxyS 7327342 oxyS Mycobacterium leprae Br4923 LysR family transcriptional regulator YP_002504328.1 3189244 R 561304 CDS YP_002504329.1 221230913 7327344 3190644..3191399 1 NC_011896.1 hypothetical protein 3191399 7327344 MLBr_02664 Mycobacterium leprae Br4923 hypothetical protein YP_002504329.1 3190644 D 561304 CDS YP_002504330.1 221230914 7327138 complement(3193575..3193829) 1 NC_011896.1 hypothetical protein 3193829 7327138 MLBr_02666 Mycobacterium leprae Br4923 hypothetical protein YP_002504330.1 3193575 R 561304 CDS YP_002504331.1 221230915 7327139 complement(3194418..3196274) 1 NC_011896.1 membrane transport protein 3196274 7327139 MLBr_02667 Mycobacterium leprae Br4923 membrane transport protein YP_002504331.1 3194418 R 561304 CDS YP_002504332.1 221230916 7327141 3197296..3197616 1 NC_011896.1 hypothetical protein 3197616 7327141 MLBr_02669 Mycobacterium leprae Br4923 hypothetical protein YP_002504332.1 3197296 D 561304 CDS YP_002504333.1 221230917 7327142 complement(3197830..3199830) 1 NC_011896.1 hypothetical protein 3199830 7327142 MLBr_02670 Mycobacterium leprae Br4923 hypothetical protein YP_002504333.1 3197830 R 561304 CDS YP_002504334.1 221230918 7327143 3204579..3209408 1 NC_011896.1 cation transport ATPase 3209408 7327143 MLBr_02671 Mycobacterium leprae Br4923 cation transport ATPase YP_002504334.1 3204579 D 561304 CDS YP_002504335.1 221230919 7327144 complement(3210516..3212756) 1 NC_011896.1 NADP; isocitrate dehydrogenase 3212756 icd2 7327144 icd2 Mycobacterium leprae Br4923 isocitrate dehydrogenase YP_002504335.1 3210516 R 561304 CDS YP_002504336.1 221230920 7327147 3221564..3222274 1 NC_011896.1 TetR family transcriptional regulator 3222274 7327147 MLBr_02677 Mycobacterium leprae Br4923 TetR family transcriptional regulator YP_002504336.1 3221564 D 561304 CDS YP_002504337.1 221230921 7327148 3222271..3225273 1 NC_011896.1 hypothetical protein 3225273 7327148 MLBr_02678 Mycobacterium leprae Br4923 hypothetical protein YP_002504337.1 3222271 D 561304 CDS YP_002504338.1 221230922 7327149 3225270..3227951 1 NC_011896.1 hypothetical protein 3227951 7327149 MLBr_02679 Mycobacterium leprae Br4923 hypothetical protein YP_002504338.1 3225270 D 561304 CDS YP_002504339.1 221230923 7327150 complement(3230183..3231997) 1 NC_011896.1 replicative DNA helicase 3231997 dnaB 7327150 dnaB Mycobacterium leprae Br4923 replicative DNA helicase YP_002504339.1 3230183 R 561304 CDS YP_002504340.1 221230924 7327151 complement(3232547..3233005) 1 NC_011896.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 3233005 rplI 7327151 rplI Mycobacterium leprae Br4923 50S ribosomal protein L9 YP_002504340.1 3232547 R 561304 CDS YP_002504341.1 221230925 7326647 complement(3233053..3233307) 1 NC_011896.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 3233307 rpsR 7326647 rpsR Mycobacterium leprae Br4923 30S ribosomal protein S18 YP_002504341.1 3233053 R 561304 CDS YP_002504342.1 221230926 7325958 complement(3233333..3233839) 1 NC_011896.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 3233839 ssb 7325958 ssb Mycobacterium leprae Br4923 single-stranded DNA-binding protein YP_002504342.1 3233333 R 561304 CDS YP_002504343.1 221230927 7326001 complement(3233999..3234289) 1 NC_011896.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 3234289 rpsF 7326001 rpsF Mycobacterium leprae Br4923 30S ribosomal protein S6 YP_002504343.1 3233999 R 561304 CDS YP_002504344.1 221230928 7327152 complement(3234837..3236531) 1 NC_011896.1 hypothetical protein 3236531 7327152 MLBr_02687 Mycobacterium leprae Br4923 hypothetical protein YP_002504344.1 3234837 R 561304 CDS YP_002504345.1 221230929 7327153 complement(3236528..3238654) 1 NC_011896.1 penicillin-bonding protein 3238654 ponA 7327153 ponA Mycobacterium leprae Br4923 penicillin-bonding protein YP_002504345.1 3236528 R 561304 CDS YP_002504346.1 221230930 7324982 complement(3239052..3239468) 1 NC_011896.1 hypothetical protein 3239468 7324982 MLBr_02689 Mycobacterium leprae Br4923 hypothetical protein YP_002504346.1 3239052 R 561304 CDS YP_002504347.1 221230931 7327155 3240667..3241209 1 NC_011896.1 hypothetical protein 3241209 7327155 MLBr_02691 Mycobacterium leprae Br4923 hypothetical protein YP_002504347.1 3240667 D 561304 CDS YP_002504348.1 221230932 7327156 3241290..3242399 1 NC_011896.1 hypothetical protein 3242399 7327156 MLBr_02692 Mycobacterium leprae Br4923 hypothetical protein YP_002504348.1 3241290 D 561304 CDS YP_002504349.1 221230933 7327160 3246650..3247381 1 NC_011896.1 MarR-family regulatory protein 3247381 7327160 MLBr_02696 Mycobacterium leprae Br4923 MarR-family regulatory protein YP_002504349.1 3246650 D 561304 CDS YP_002504350.1 221230934 7327161 complement(3248136..3249596) 1 NC_011896.1 polynucleotide polymerase; pcnA 3249596 pcnA 7327161 pcnA Mycobacterium leprae Br4923 pcnA YP_002504350.1 3248136 R 561304 CDS YP_002504351.1 221230935 7327358 3249783..3250538 1 NC_011896.1 hypothetical protein 3250538 7327358 MLBr_02698 Mycobacterium leprae Br4923 hypothetical protein YP_002504351.1 3249783 D 561304 CDS YP_002504352.1 221230936 7327162 3250535..3252928 1 NC_011896.1 hypothetical protein 3252928 7327162 MLBr_02699 Mycobacterium leprae Br4923 hypothetical protein YP_002504352.1 3250535 D 561304 CDS YP_002504353.1 221230937 7327163 3252925..3256545 1 NC_011896.1 hypothetical protein 3256545 7327163 MLBr_02700 Mycobacterium leprae Br4923 hypothetical protein YP_002504353.1 3252925 D 561304 CDS YP_002504354.1 221230938 7327165 3258118..3259494 1 NC_011896.1 thioredoxin; bifunctional thioredoxin reductase/thioredoxin 3259494 trx 7327165 trx Mycobacterium leprae Br4923 bifunctional thioredoxin reductase/thioredoxin YP_002504354.1 3258118 D 561304 CDS YP_002504355.1 221230939 7327289 3259627..3260847 1 NC_011896.1 hydrolase 3260847 7327289 MLBr_02704 Mycobacterium leprae Br4923 hydrolase YP_002504355.1 3259627 D 561304 CDS YP_002504356.1 221230940 7327166 complement(3260844..3261623) 1 NC_011896.1 hypothetical protein 3261623 7327166 MLBr_02705 Mycobacterium leprae Br4923 hypothetical protein YP_002504356.1 3260844 R 561304 CDS YP_002504357.1 221230941 7327167 complement(3261976..3262983) 1 NC_011896.1 cell division protein 3262983 parB 7327167 parB Mycobacterium leprae Br4923 cell division protein YP_002504357.1 3261976 R 561304 CDS YP_002504358.1 221230942 7327353 complement(3262980..3264035) 1 NC_011896.1 cell division protein 3264035 parA 7327353 parA Mycobacterium leprae Br4923 cell division protein YP_002504358.1 3262980 R 561304 CDS YP_002504359.1 221230943 7327352 complement(3264032..3264778) 1 NC_011896.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3264778 gidB 7327352 gidB Mycobacterium leprae Br4923 16S rRNA methyltransferase GidB YP_002504359.1 3264032 R 561304 CDS YP_002504360.1 221230944 7327168 complement(3264850..3265431) 1 NC_011896.1 hypothetical protein 3265431 7327168 MLBr_02709 Mycobacterium leprae Br4923 hypothetical protein YP_002504360.1 3264850 R 561304 CDS YP_002504361.1 221230945 7327169 complement(3265513..3266655) 1 NC_011896.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3266655 7327169 MLBr_02710 Mycobacterium leprae Br4923 inner membrane protein translocase component YidC YP_002504361.1 3265513 R 561304 CDS YP_002504362.1 221230946 7327171 complement(3266994..3267356) 1 NC_011896.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3267356 rnpA 7327171 rnpA Mycobacterium leprae Br4923 ribonuclease P YP_002504362.1 3266994 R 561304 CDS YP_002504363.1 221230947 7326634 complement(3267378..3267521) 1 NC_011896.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3267521 rpmH 7326634 rpmH Mycobacterium leprae Br4923 50S ribosomal protein L34 YP_002504363.1 3267378 R 561304 CDS